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JOURNAL ARTICLE
Eleanor M Moncur, Claudia L Craven, Selma Al-Ahmad, Bethany Jones, Fergus Robertson, Ugan Reddy, Ahmed K Toma
BACKGROUND: Delayed cerebral ischaemia (DCI) is a major cause of morbidity and mortality after aneurysmal subarachnoid haemorrhage (aSAH). Chemical angioplasty (CA) and transluminal balloon angioplasty (TBA) are used to treat patients with refractory vasospasm causing DCI. Multi-modal monitoring including brain tissue oxygenation (PbtO2 ) is routinely used at this centre for early detection and management of DCI following aSAH. In this single-centre pilot study, we are comparing these two treatment modalities and their effects on PbtO2 ...
April 16, 2024: Acta Neurochirurgica
#2
JOURNAL ARTICLE
Annika Nelskylä, Jaana Humaloja, Erik Litonius, Pirkka Pekkarinen, Giovanni Babini, Tomi P Mäki-Aho, Juho A Heinonen, Markus B Skrifvars
INTRODUCTION: Perfusion pressure and chest compression quality are generally considered key determinants of brain oxygenation during cardiopulmonary resuscitation (CPR) and the impact of oxygen administration is less clear. We compared ventilation with 100% and 50% oxygen during ineffective manual chest compressions and hypothesized that 100% oxygen would improve brain oxygenation. METHODS: Ventricular fibrillation (VF) was induced electrically in anaesthetized pigs and left untreated for 5 minutes, followed by randomization to ineffective manual CPR with ventilation of 50% or 100% oxygen...
January 2023: Resuscitation
#3
JOURNAL ARTICLE
Victor F Velazquez Sanchez, Giath Al Dayri, Christoph A Tschan
BACKGROUND: Idiopathic intracranial hypertension (IIH) is a disease which is difficult to diagnose and moreover difficult to treat. We developed a strategy for long-term telemonitoring of intracranial pressure (ICP), by incorporation of the NEUROVENT®-P-tel System, with the goal of improved diagnosis and consequent therapy of this disease. We highlight the results obtained through this approach. METHODS: Twenty patients with suspected IIH who were treated in our hospital from August 2014 to October 2020 (16 females, 4 males, median age 36,6 years), were assigned to one of two ICP monitoring settings, "Home-Telemonitoring" (n = 12) and "Home-Monitoring" (n = 8)...
September 7, 2021: BMC Neurology
#4
JOURNAL ARTICLE
Claudia L Craven, Morrakot Sae-Huang, Chandrashekar Hoskote, Laurence D Watkins, Ugan Reddy, Ahmed K Toma
BACKGROUND: Multimodal monitoring of intracranial pressure and brain tissue oxygen tension (PbtO2 ) have been increasingly used to detect delayed cerebral ischemia (DCI) after subarachnoid hemorrhage. At our center, patients who cannot be easily assessed clinically will undergo intracranial pressure and PbtO2 monitoring via a NEUROVENT-PTO bolt. We aimed to determine whether the Lindegaard ratios (LRs) computed from transcranial Doppler ultrasonography (TCDU) would correlate with, or can predict, the simultaneously recorded PbtO2 value...
January 26, 2021: World Neurosurgery
#5
JOURNAL ARTICLE
Stefanos I Korfias, Stamatios Banos, Athanasia Alexoudi, Kostas Themistoklis, Efstathios Vlachakis, Panayiotis Patrikelis, Stergios Gatzonis, Damianos E Sakas
INTRODUCTION: We present the application of the Raumedic® P-tel telemetric device that monitors Intracranial Pressure (ICP) over long periods, in 22 patients, with suspected intracranial hypertension. METHODS: A telemetric device (Raumedic® , Neurovent® P-tel) was surgically implanted in 22 patients aged between 21 and 65 years. Among the patients, the inconclusive diagnosis of benign intracranial hypertension was set in 10, the possible diagnosis of postoperative hydrocephalus in 3, and the possible diagnosis of aqueduct stenosis in 2...
August 2021: British Journal of Neurosurgery
#6
JOURNAL ARTICLE
Jessica A I Muller, Nicole Lawrence, Lai Yue Chan, Peta J Harvey, Alysha G Elliott, Mark A T Blaskovich, Jacqueline C Gonçalves, Priscilla Galante, Marcia R Mortari, Mônica C Toffoli-Kadri, Johannes Koehbach, David Craik
Agelaia-MPI and protonectin are antimicrobial peptides isolated from the wasp Parachartergus fraternus that show antimicrobial and neuroactive activities. Previously, two analogues of these peptides, neuroVAL and protonectin-F were designed to reduce nonspecific toxicity and improve potency. Here, the three-dimensional structures of neuroVAL, protonectin and protonectin-F were determined using circular dichroism and NMR spectroscopy. Antibacterial, antifungal and cytotoxic and hemolytic activities were tested for the parent peptides and analogues...
November 26, 2020: Chembiochem: a European Journal of Chemical Biology
#7
MULTICENTER STUDY
Vivek Vijay, Susan P Mollan, James L Mitchell, Edward Bilton, Zerin Alimajstorovic, Keira A Markey, Anthony Fong, Jessica K Walker, Hannah S Lyons, Andreas Yiangou, Georgios Tsermoulas, Kristian Brock, Alexandra J Sinclair
Importance: There is an unmet need for noninvasive biomarkers of intracranial pressure (ICP), which manifests as papilledema that can be quantified by optical coherence tomography (OCT) imaging. Objective: To determine whether OCT of the optic nerve head in papilledema could act as a surrogate measure of ICP. Design, Setting, and Participants: This longitudinal cohort study used data collected from 3 randomized clinical trials that were conducted between April 1, 2014, and August 1, 2019...
December 1, 2020: JAMA Ophthalmology
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COMPARATIVE STUDY
S Rot, M Dweek, P Gutowski, L Goelz, U Meier, J Lemcke
OBJECTIVES: Measurement of intracranial pressure (ICP) plays an important role in long-term monitoring and neuro-intensive treatment of patients with a cerebral shunt. Currently, only two complete telemetric implants with different technical features are available worldwide. This prospective pilot study aims to examine patients who had both probes implanted at overlapping times for clinical reasons and represents the first in vivo comparison of both measurement methods. MATERIALS AND METHODS: Patients with a primary subarachnoid hemorrhage or a spontaneous intracerebral hemorrhage with ventricular hemorrhage who had received a telemetric ICP probe (Raumedic® NEUROVENT® -P-tel) were included in the study...
October 17, 2020: Fluids and Barriers of the CNS
#9
JOURNAL ARTICLE
Valentina Pennacchietti, Vincent Prinz, Andreas Schaumann, Tobias Finger, Matthias Schulz, Ulrich W Thomale
BACKGROUND: Hydrocephalus may present with heterogeneous signs and symptoms. The indication for its treatment and the optimal drainage in complex cases may be challenging. Telemetric intracranial pressure measurements (TICPM) may open new perspectives for those circumstances. We report our experiences using the Neurovent-P-tel and the Sensor Reservoir in a retrospective study. METHODS: A series of 21 patients (age range 10-39.5 years) treated in our Pediatric Neurosurgical Unit receiving a TICPM was analyzed...
June 3, 2020: Acta Neurochirurgica
#10
JOURNAL ARTICLE
Sarah Hornshøj Pedersen, Nicolas Hernandez Norager, Alexander Lilja-Cyron, Marianne Juhler
PURPOSE: Repeated intracranial pressure (ICP) measurements are essential in treatment of patients with complex cerebrospinal fluid (CSF) disorders. These patients often have a long surgical history with numerous invasive lumbar or intracranial pressure monitoring sessions and/or ventriculoperitoneal (VP) shunt revisions. Telemetric ICP monitoring might be an advantageous tool in treatment of these patients. In this paper, we evaluate our experience with this technology in paediatric patients...
January 2020: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#11
JOURNAL ARTICLE
Nicolas Hernandez Norager, Alexander Lilja-Cyron, Torben Skovbo Hansen, Marianne Juhler
BACKGROUND: The clinical advantage of telemetric intracranial pressure (ICP) monitoring has previously been limited by issues with inaccuracy and zero-drift. Today, 2 comparable telemetric ICP monitoring systems are available performing adequately in these parameters. The objective of this study is to identify appropriate uses of each system. METHODS: The 2 telemetric ICP monitoring systems from Raumedic (implant: Neurovent-P-tel) and Miethke (implant: Sensor Reservoir) are compared in terms of fundamental differences, sensor survival, monitoring possibilities, complications, and cost/benefit...
June 2019: World Neurosurgery
#12
JOURNAL ARTICLE
Alexander Lilja-Cyron, Morten Andresen, Jesper Kelsen, Trine Hjorslev Andreasen, Kåre Fugleholm, Marianne Juhler
BACKGROUND: Decompressive craniectomy (DC) is used in cases of severe intracranial hypertension or impending intracranial herniation. DC effectively lowers intracranial pressure (ICP) but carries a risk of severe complications related to abnormal ICP and/or cerebrospinal fluid (CSF) circulation, eg, hygroma formation, hydrocephalus, and "syndrome of the trephined." OBJECTIVE: To study the long-term effect of DC on ICP, postural ICP regulation, and intracranial pulse wave amplitude (PWA)...
February 1, 2020: Neurosurgery
#13
JOURNAL ARTICLE
Nicolas Hernandez Norager, Alexander Lilja-Cyron, Carsten Reidies Bjarkam, Sara Duus, Marianne Juhler
BACKGROUND: Telemetric intracranial pressure (ICP) monitoring enable long-term ICP monitoring on patients during normal day activities and may accordingly be of use during evaluation and treatment of complicated ICP disorders. However, the benefits of such equipment depend strongly on the validity of the recordings and how often the telemetric sensor needs to be re-implanted. This study investigates the clinical and technical sensor survival time and drift of the telemetric ICP sensor: Raumedic Neurovent-P-tel...
November 2018: Acta Neurochirurgica
#14
JOURNAL ARTICLE
Jorge Tirado-Caballero, Andres Muñoz-Nuñez, Santiago Rocha-Romero, Mónica Rivero-Garvía, Emilio Gomez-González, Javier Marquez-Rivas
Intracranial pressure (ICP) measurements are imperative for the proper diagnosis and treatment of several neurological disorders. Telemetric sensors have shown their utility for ICP estimation in short-term monitoring in humans. However, their long-term reliability is uncertain. The authors present the case of a 37-year-old woman diagnosed with benign intracranial hypertension and obesity. The patient underwent gastric bypass surgery for ICP control. In order to monitor ICP before and after bariatric surgery, a Neurovent-P-tel sensor was implanted in the left frontal lobe...
August 31, 2018: Journal of Neurosurgery
#15
JOURNAL ARTICLE
Alexander Lilja-Cyron, Jesper Kelsen, Morten Andresen, Kåre Fugleholm, Marianne Juhler
Intracranial pressure (ICP) monitoring is crucial in the management of acute neurosurgical conditions such as traumatic brain injury (TBI). However, pathological ICP may persist beyond the admission to the neuro intensive care unit (NICU). We investigated the feasibility of telemetric ICP monitoring in the NICU, as this technology provides the possibility of long-term ICP assessment beyond NICU discharge. In this prospective investigation, we implanted telemetric ICP sensors (Raumedic Neurovent-P-tel) instead of conventional, cabled ICP sensors in patients undergoing decompressive craniectomy...
July 15, 2018: Journal of Neurotrauma
#16
JOURNAL ARTICLE
Annika Nelskylä, Jouni Nurmi, Milla Jousi, Alexey Schramko, Eero Mervaala, Giuseppe Ristagno, Markus B Skrifvars
BACKGROUND AND AIM: We hypothesised that the use of 50% compared to 100% oxygen maintains cerebral oxygenation and ameliorates the disturbance of cardiac mitochondrial respiration during cardiopulmonary resuscitation (CPR). METHODS: Ventricular fibrillation (VF) was induced electrically in anaesthetised healthy adult pigs and left untreated for seven minutes followed by randomisation to manual ventilation with 50% or 100% oxygen and mechanical chest compressions (LUCAS® )...
July 2017: Resuscitation
#17
JOURNAL ARTICLE
Sebastian Antes, Christoph A Tschan, Michael Heckelmann, David Breuskin, Joachim Oertel
BACKGROUND: Devices enabling long-term intracranial pressure monitoring have been demanded for some time. The first solutions using telemetry were proposed in 1967. Since then, many other wireless systems have followed but some technical restrictions have led to unacceptable measurement uncertainties. In 2009, a completely revised telemetric pressure device called Neurovent P-tel was introduced to the market. This report reviews technical aspects, handling, possibilities of data analysis, and the efficiency of the probe in clinical routine...
July 2016: World Neurosurgery
#18
JOURNAL ARTICLE
Sara Magnéli, Timothy Howells, Daniel Saiepour, Daniel Nowinski, Per Enblad, Pelle Nilsson
INTRODUCTION: There are no reliable noninvasive methods of monitoring ICP. Most assessments are made by indirect measures and are difficult to follow over time. Invasive studies can be used but up until now have required in-hospital transcutaneous measurements. Accurate ICP recordings over longer periods of time can be very valuable in timing different surgical procedures in syndromal cases. This case shows that telemetric ICP monitoring can be used for long-term follow-up in patients that may need repeated surgeries related to their craniosynostosis condition...
July 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#19
RANDOMIZED CONTROLLED TRIAL
Thien-Tri Cung, Olivier Morel, Guillaume Cayla, Gilles Rioufol, David Garcia-Dorado, Denis Angoulvant, Eric Bonnefoy-Cudraz, Patrice Guérin, Meier Elbaz, Nicolas Delarche, Pierre Coste, Gerald Vanzetto, Marc Metge, Jean-François Aupetit, Bernard Jouve, Pascal Motreff, Christophe Tron, Jean-Noel Labeque, Philippe Gabriel Steg, Yves Cottin, Grégoire Range, Jérome Clerc, Marc J Claeys, Patrick Coussement, Fabrice Prunier, Frédéric Moulin, Olivier Roth, Loïc Belle, Philippe Dubois, Paul Barragan, Martine Gilard, Christophe Piot, Patrice Colin, Fabien De Poli, Marie-Claude Morice, Omar Ider, Jean-Luc Dubois-Randé, Thierry Unterseeh, Hervé Le Breton, Thierry Béard, Didier Blanchard, Gilles Grollier, Vincent Malquarti, Patrick Staat, Arnaud Sudre, Eskil Elmer, Magnus J Hansson, Cyrille Bergerot, Inesse Boussaha, Claire Jossan, Geneviève Derumeaux, Nathan Mewton, Michel Ovize
BACKGROUND: Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine would improve clinical outcomes and prevent adverse left ventricular remodeling. METHODS: In a multicenter, double-blind, randomized trial, we assigned 970 patients with an acute anterior ST-segment elevation myocardial infarction (STEMI) who were undergoing percutaneous coronary intervention (PCI) within 12 hours after symptom onset and who had complete occlusion of the culprit coronary artery to receive a bolus injection of cyclosporine (administered intravenously at a dose of 2...
September 10, 2015: New England Journal of Medicine
#20
JOURNAL ARTICLE
Karlis Purins, Anders Lewén, Lars Hillered, Tim Howells, Per Enblad
INTRODUCTION: Neurointensive care of traumatic brain injury (TBI) patients is currently based on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) targeted protocols. There are reasons to believe that knowledge of brain tissue oxygenation (BtipO2) would add information with the potential of improving patient outcome. The aim of this study was to examine BtipO2 and cerebral metabolism using the Neurovent-PTO probe and cerebral microdialysis (MD) in TBI patients. METHODS: Twenty-three severe TBI patients with monitoring of physiological parameters, ICP, CPP, BtipO2, and MD for biomarkers of energy metabolism (glucose, lactate, and pyruvate) and cellular distress (glutamate, glycerol) were included...
2014: Frontiers in Neurology
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