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https://www.readbyqxmd.com/read/27914963/hypothermia-in-mouse-is-caused-by-adenosine-a1-and-a3-receptor-agonists-and-amp-via-three-distinct-mechanisms
#1
Jesse Lea Carlin, Shalini Jain, Elizabeth Gizewski, Tina C Wan, Dilip K Tosh, Cuiying Xiao, John A Auchampach, Kenneth A Jacobson, Oksana Gavrilova, Marc L Reitman
Small mammals have the ability to enter torpor, a hypothermic, hypometabolic state, allowing impressive energy conservation. Administration of adenosine or adenosine 5'-monophosphate (AMP) can trigger a hypothermic, torpor-like state. We investigated the mechanisms for hypothermia using telemetric monitoring of body temperature in wild type and receptor knock out (Adora1(-/-)-/-, Adora3(-/-)) mice. Confirming prior data, stimulation of the A3 adenosine receptor (AR) induced hypothermia via peripheral mast cell degranulation, histamine release, and activation of central histamine H1 receptors...
November 30, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27864544/investigative-nonclinical-cardiovascular-safety-and-toxicology-studies-with-bms-986094-an-ns5b-rna-dependent-rna-polymerase-inhibitor
#2
M Gill, K Horn, J Hennan, R White, D Bounous, S Clark, J R Megill, E Janovitz, M Davies, T Sanderson, M Graziano
BMS-986094, a 2'-C-methylguanosine prodrug that was in development for treatment of chronic hepatitis C infection was withdrawn from Phase 2 clinical trials because of unexpected cardiac and renal adverse events. Investigative nonclinical studies were conducted to extend the understanding of these findings using more comprehensive endpoints. BMS-986094 was given orally to female CD-1 mice (25 and 150 mg/kg/d) for 2 weeks (53/group) and to cynomolgus monkeys (15 and 30 mg/kg/d) for up to 6 weeks (2-3/sex/group for cardiovascular safety, and 5/sex/group for toxicology)...
November 17, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27856454/endothelial-cell-specific-deletion-of-p2y2-receptor-promotes-plaque-stability-in-atherosclerosis-susceptible-apoe-null-mice
#3
Chen Xingjuan, Shaomin Qian, April Hoggatt, Hongying Tang, Timothy A Hacker, Alexander G Obukhov, Paul B Herring, Cheikh I Seye
OBJECTIVE: Nucleotide P2Y2 receptor (P2Y2R) contributes to vascular inflammation by increasing vascular cell adhesion molecule-1 expression in endothelial cells (EC), and global P2Y2R deficiency prevents fatty streak formation in apolipoprotein E null (ApoE(-/-)) mice. Because P2Y2R is ubiquitously expressed in vascular cells, we investigated the contribution of endothelial P2Y2R in the pathogenesis of atherosclerosis. APPROACH AND RESULTS: EC-specific P2Y2R-deficient mice were generated by breeding VEcadherin5-Cre mice with the P2Y2R floxed mice...
November 17, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27848030/-implantable-loop-recorder-biomonitor%C3%A2-2-biotronik
#4
Thorsten Lewalter, Clemens Jilek
The implantable loop recorder BioMonitor 2 is available with an emphasis on syncope and one on detection of atrial tachycardias. The BioMonitor 2 can be easily implanted. The BioMonitor 2 pilot study showed a high and over time stable signal and the telemetric performance was above average.
November 15, 2016: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/27825150/oxygen-uptake-recovery-kinetics-after-the-6-minute-walk-test-in-patients-with-chronic-obstructive-pulmonary-disease
#5
Florent Baty, Arnoldus J R van Gestel, Lukas Kern, Martin H Brutsche
BACKGROUND: There is a growing interest in exercise parameters capable of objectively evaluating the functional capacity of patients with chronic obstructive pulmonary disease (COPD). OBJECTIVES: The purpose of the present study was to analyze breath-by-breath cardiopulmonary and gas exchange recovery responses of patients with COPD after a 6-minute walk test (6MWT). METHODS: Oxygen uptake (VO2) kinetics of patients were obtained using mobile telemetric cardiopulmonary monitoring during and after a 6MWT...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27798189/a-decline-in-response-variability-improves-neural-signal-detection-during-auditory-task-performance
#6
Gardiner von Trapp, Bradley N Buran, Kamal Sen, Malcolm N Semple, Dan H Sanes
: The detection of a sensory stimulus arises from a significant change in neural activity, but a sensory neuron's response is rarely identical to successive presentations of the same stimulus. Large trial-to-trial variability would limit the central nervous system's ability to reliably detect a stimulus, presumably affecting perceptual performance. However, if response variability were to decrease while firing rate remained constant, then neural sensitivity could improve. Here, we asked whether engagement in an auditory detection task can modulate response variability, thereby increasing neural sensitivity...
October 26, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27797835/the-development-of-nociceptive-network-activity-in-the-somatosensory-cortex-of-freely-moving-rat-pups
#7
P Chang, L Fabrizi, S Olhede, M Fitzgerald
Cortical perception of noxious stimulation is an essential component of pain experience but it is not known how cortical nociceptive activity emerges during brain development. Here we use continuous telemetric electrocorticogram (ECoG) recording from the primary somatosensory cortex (S1) of awake active rat pups to map functional nociceptive processing in the developing brain over the first 4 weeks of life. Cross-sectional and longitudinal recordings show that baseline S1 ECoG energy increases steadily with age, with a distinctive beta component replaced by a distinctive theta component in week 3...
October 26, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27736193/circadian-rhythm-in-qt-interval-is-preserved-in-mice-deficient-of-potassium-channel-interacting-protein-2
#8
Lisa A Gottlieb, Anniek Lubberding, Anders Peter Larsen, Morten B Thomsen
Potassium Channel Interacting Protein 2 (KChIP2) is suggested to be responsible for the circadian rhythm in repolarization duration, ventricular arrhythmias, and sudden cardiac death. We investigated the hypothesis that there is no circadian rhythm in QT interval in the absence of KChIP2. Implanted telemetric devices recorded electrocardiogram continuously for 5 days in conscious wild-type mice (WT, n = 9) and KChIP2(-/-) mice (n = 9) in light:dark periods and in complete darkness. QT intervals were determined from all RR intervals and corrected for heart rate (QT100 = QT/(RR/100)(1/2))...
October 13, 2016: Chronobiology International
https://www.readbyqxmd.com/read/27734806/increased-sample-asymmetry-and-memory-of-cardiac-time-series-following-endotoxin-administration-in-cirrhotic-rats
#9
Mina Taghipour, Golnar Eftekhari, Zahra Haddadian, Roham Mazloom, Mohammad Mani, Ali R Mani
Sepsis, and other causes of acute systemic inflammation, can reduce heart rate variability (HRV) and increase cardiac cycle regularity in mammals. Thus, HRV monitoring has been used for early detection of sepsis in adults and neonates. Liver cirrhosis is associated with reduced basal HRV and the development of tolerance to the cardiac chronotropic effects of bacterial endotoxin. This may pose limitations on the use of heart rate monitoring in early detection of sepsis in this patient population. In a study to develop a physiomarker for the detection of sepsis in cirrhosis, we observed that endotoxin administration in adult cirrhotic rats leads to the development of transient heart rate decelerations, a phenomenon which has been reported in neonates with sepsis, and quantified using sample asymmetry analysis...
October 13, 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27712650/effects-of-nmda-and-non-nmda-ionotropic-glutamate-receptors-in-the-medial-preoptic-area-on-body-temperature-in-awake-rats
#10
Trina Sengupta, Ashok Kumar Jaryal, Hruda Nanda Mallick
Glutamate when microinjected at the medial preoptic area (mPOA) influences brain temperature (Tbr) and body temperature (Tb) in rats. Glutamate and its various receptors are present at the mPOA. The aim of this study was to identify the contribution of each of the ionotropic glutamatergic receptors at the mPOA on changes in Tbr and Tb in freely moving rats. Adult male Wistar rats (n=40) were implanted with bilateral guide cannula with indwelling styli above the mPOA. A telemetric transmitter was implanted at the peritoneum to record Tb and locomotor activity (LMA)...
October 2016: Journal of Thermal Biology
https://www.readbyqxmd.com/read/27708585/comparative-analysis-of-the-equivital-eq02-lifemonitor-with-holter-ambulatory-ecg-device-for-continuous-measurement-of-ecg-heart-rate-and-heart-rate-variability-a-validation-study-for-precision-and-accuracy
#11
Abimbola A Akintola, Vera van de Pol, Daniel Bimmel, Arie C Maan, Diana van Heemst
Background: The Equivital (EQ02) is a multi-parameter telemetric device offering both real-time and/or retrospective, synchronized monitoring of ECG, HR, and HRV, respiration, activity, and temperature. Unlike the Holter, which is the gold standard for continuous ECG measurement, EQO2 continuously monitors ECG via electrodes interwoven in the textile of a wearable belt. Objective: To compare EQ02 with the Holter for continuous home measurement of ECG, heart rate (HR), and heart rate variability (HRV). Methods: Eighteen healthy participants wore, simultaneously for 24 h, the Holter and EQ02 monitors...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27687952/clinical-histopathological-and-metabolic-responses-following-exercise-in-arabian-horses-with-a-history-of-exertional-rhabdomyolysis
#12
E C McKenzie, L V Eyrich, M E Payton, S J Valberg
A previous report suggests a substantial incidence of exertional rhabdomyolysis (ER) in Arabian horses performing endurance racing. This study compared formalin histopathology and clinical and metabolic responses to a standardised field exercise test (SET) between Arabians with and without ER. Arabian horses with (n = 10; age 15.4 ± 5.6 years) and without (n = 9; 12.9 ± 6.1 years) prior ER were stall-rested for 24-48 h, after which paired ER and control horses were fitted with a telemetric ECG and performed a 47 min submaximal SET...
October 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27667030/enhanced-cardiac-tbc1d10c-expression-lowers-heart-rate-and-enhances-exercise-capacity-and-survival
#13
Cornelia Volland, Sebastian Bremer, Kristian Hellenkamp, Nico Hartmann, Nataliya Dybkova, Sara Khadjeh, Anna Kutschenko, David Liebetanz, Stefan Wagner, Bernhard Unsöld, Michael Didié, Karl Toischer, Samuel Sossalla, Gerd Hasenfuß, Tim Seidler
TBC1D10C is a protein previously demonstrated to bind and inhibit Ras and Calcineurin. In cardiomyocytes, also CaMKII is inhibited and all three targeted enzymes are known to promote maladaptive cardiomyocyte hypertrophy. Here, in accordance with lack of Calcineurin inhibition in vivo, we did not observe a relevant anti-hypertrophic effect despite inhibition of Ras and CaMKII. However, cardiomyocyte-specific TBC1D10C overexpressing transgenic mice exhibited enhanced longevity. Ejection fraction and exercise capacity were enhanced in transgenic mice, but shortening of isolated cardiomyocytes was not increased...
September 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27666651/an-evaluation-of-the-breathing-strategies-and-maximum-phonation-time-in-musical-theater-performers-during-controlled-performance-tasks
#14
Tommi Sliiden, Sara Beck, Ian MacDonald
OBJECTIVES: Breathing strategies for athletic dancing are quite different from those needed for legato singing. This study considers the respiration data recorded by a telemetric heart rate monitor, mask, and gas analyzer collected from 20 musical theater professionals performing set tasks. METHODS: Scores were taken of maximum phonation time (MPT), relative oxygen uptake, and heart rate immediately after three tasks: (1) singing only, (2) dancing only, and (3) singing while dancing...
September 22, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27647493/the-5-ht6-receptor-antagonist-idalopirdine-potentiates-the-effects-of-donepezil-on-gamma-oscillations-in-the-frontal-cortex-of-anesthetized-and-awake-rats-without-affecting-sleep-wake-architecture
#15
Maria Amat-Foraster, Steven C Leiser, Kjartan F Herrik, Nelly Richard, Claus Agerskov, Christoffer Bundgaard, Jesper F Bastlund, Inge E M de Jong
The 5-HT6 receptor is a promising target for cognitive disorders, in particular for Alzheimer's disease (AD). The high affinity and selective 5-HT6 receptor antagonist idalopirdine (Lu AE58054) is currently in development for mild-moderate AD as adjunct therapy to acetylcholinesterase inhibitors (AChEIs). We studied the effects of idalopirdine alone and in combination with the AChEI donepezil on cortical function using two in vivo electrophysiological methods. Neuronal network oscillations in the frontal cortex were measured during electrical stimulation of the brainstem nucleus pontis oralis (nPO) in the anesthetized rat and by an electroencephalogram (EEG) in the awake, freely moving rat...
September 16, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27644335/telemetric-intra-cranial-pressure-monitoring-clinical-and-financial-considerations
#16
James M Barber, Catherine J Pringle, Helen Raffalli-Ebezant, Omar Pathmanaban, Roberto Ramirez, Ian D Kamaly-Asl
Intracranial pressure (ICP) measurement is an important diagnostic tool in Neurosurgery. Until relatively recently, conventional monitoring has required that subjects be admitted to a hospital bed and the device is only able to be left in-situ for limited periods of time. We have evaluated a Telemetric ICP monitoring system that has been proven, by several other groups worldwide, to permit rapid, repeated and prolonged ICP measurement, in multiple environments. In our unit, 4 patients have been implanted to-date, between the ages of 4 and 16, manifesting a wide range of complex neurosurgical conditions...
September 19, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27613649/anodal-stimulation-in-two-dogs-with-transvenous-permanent-bipolar-pacemakers
#17
M A Oyama, M J Hezzell, D S Laughlin, C L Thorn, M S Kraus, A R Gelzer
Management of symptomatic bradyarrhythmias such as complete atrioventricular block often involves permanent implantation of a transvenous pacemaker. Both during and after implantation, the operator can telemetrically assess and adjust a variety of electrical parameters associated with the pacemaker function in order to optimize the sensitivity, reliability, and power consumption of the device. Herein, we report an unexpected change in the paced electrocardiographic QRS complex morphology in two dogs undergoing bipolar pacing associated with changes in the pacemaker output amplitude settings first detected during threshold testing...
September 6, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27572457/eye-blinking-in-an-avian-species-is-associated-with-gaze-shifts
#18
Jessica L Yorzinski
Even when animals are actively monitoring their environment, they lose access to visual information whenever they blink. They can strategically time their blinks to minimize information loss and improve visual functioning but we have little understanding of how this process operates in birds. This study therefore examined blinking in freely-moving peacocks (Pavo cristatus) to determine the relationship between their blinks, gaze shifts, and context. Peacocks wearing a telemetric eye-tracker were exposed to a taxidermy predator (Vulpes vulpes) and their blinks and gaze shifts were recorded...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27520503/real-time-monitoring-of-glucose-and-phenols-intestinal-absorption-through-an-integrated-caco-2tc7cells-biosensors-telemetric-device-hypoglycemic-effect-of-fruit-phytochemicals
#19
Barberis Antonio, Garbetta Antonella, Cardinali Angela, Bazzu Gianfranco, D 'Antuono Isabella, Rocchitta Gaia, Fadda Angela, Linsalata Vito, D 'Hallewin Guy, Serra Pier Andrea, Minervini Fiorenza
An integrated device for real-time monitoring of glucose and phenols absorption, that consists of a sensors/biosensors system (SB) and a Caco-2TC7 human intestinal cell culture, is described in this study. The SB is composed of a glucose oxidase-based biosensor, a sentinel platinum sensor, a laccase/tyrosinase-based biosensor and a sentinel carbon sensor, all located in the basolateral compartment (BC) of a cell culture plate. Caco-2TC7 cells, differentiated on culture inserts, separated the apical compartment that simulates the intestinal lumen, from the BC which represented the bloodstream...
August 3, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27510854/t-wave-morphology-can-distinguish-healthy-controls-from-lqts-patients
#20
S A Immanuel, A Sadrieh, M Baumert, J P Couderc, W Zareba, A P Hill, J I Vandenberg
Long QT syndrome (LQTS) is an inherited disorder associated with prolongation of the QT/QTc interval on the surface electrocardiogram (ECG) and a markedly increased risk of sudden cardiac death due to cardiac arrhythmias. Up to 25% of genotype-positive LQTS patients have QT/QTc intervals in the normal range. These patients are, however, still at increased risk of life-threatening events compared to their genotype-negative siblings. Previous studies have shown that analysis of T-wave morphology may enhance discrimination between control and LQTS patients...
September 2016: Physiological Measurement
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