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Lisa A Gottlieb, Anniek Lubberding, Anders Peter Larsen, Morten B Thomsen
Potassium Channel Interacting Protein 2 (KChIP2) is suggested to be responsible for the circadian rhythm in repolarization duration, ventricular arrhythmias, and sudden cardiac death. We investigated the hypothesis that there is no circadian rhythm in QT interval in the absence of KChIP2. Implanted telemetric devices recorded electrocardiogram continuously for 5 days in conscious wild-type mice (WT, n = 9) and KChIP2(-/-) mice (n = 9) in light:dark periods and in complete darkness. QT intervals were determined from all RR intervals and corrected for heart rate (QT100 = QT/(RR/100)(1/2))...
October 13, 2016: Chronobiology International
Mina Taghipour, Golnar Eftekhari, Zahra Haddadian, Roham Mazloom, Mohammad Mani, Ali R Mani
Sepsis, and other causes of acute systemic inflammation, can reduce heart rate variability (HRV) and increase cardiac cycle regularity in mammals. Thus, HRV monitoring has been used for early detection of sepsis in adults and neonates. Liver cirrhosis is associated with reduced basal HRV and the development of tolerance to the cardiac chronotropic effects of bacterial endotoxin. This may pose limitations on the use of heart rate monitoring in early detection of sepsis in this patient population. In a study to develop a physiomarker for the detection of sepsis in cirrhosis, we observed that endotoxin administration in adult cirrhotic rats leads to the development of transient heart rate decelerations, a phenomenon which has been reported in neonates with sepsis, and quantified using sample asymmetry analysis...
October 13, 2016: Physiological Measurement
Trina Sengupta, Ashok Kumar Jaryal, Hruda Nanda Mallick
Glutamate when microinjected at the medial preoptic area (mPOA) influences brain temperature (Tbr) and body temperature (Tb) in rats. Glutamate and its various receptors are present at the mPOA. The aim of this study was to identify the contribution of each of the ionotropic glutamatergic receptors at the mPOA on changes in Tbr and Tb in freely moving rats. Adult male Wistar rats (n=40) were implanted with bilateral guide cannula with indwelling styli above the mPOA. A telemetric transmitter was implanted at the peritoneum to record Tb and locomotor activity (LMA)...
October 2016: Journal of Thermal Biology
Abimbola A Akintola, Vera van de Pol, Daniel Bimmel, Arie C Maan, Diana van Heemst
Background: The Equivital (EQ02) is a multi-parameter telemetric device offering both real-time and/or retrospective, synchronized monitoring of ECG, HR, and HRV, respiration, activity, and temperature. Unlike the Holter, which is the gold standard for continuous ECG measurement, EQO2 continuously monitors ECG via electrodes interwoven in the textile of a wearable belt. Objective: To compare EQ02 with the Holter for continuous home measurement of ECG, heart rate (HR), and heart rate variability (HRV). Methods: Eighteen healthy participants wore, simultaneously for 24 h, the Holter and EQ02 monitors...
2016: Frontiers in Physiology
E C McKenzie, L V Eyrich, M E Payton, S J Valberg
A previous report suggests a substantial incidence of exertional rhabdomyolysis (ER) in Arabian horses performing endurance racing. This study compared formalin histopathology and clinical and metabolic responses to a standardised field exercise test (SET) between Arabians with and without ER. Arabian horses with (n = 10; age 15.4 ± 5.6 years) and without (n = 9; 12.9 ± 6.1 years) prior ER were stall-rested for 24-48 h, after which paired ER and control horses were fitted with a telemetric ECG and performed a 47 min submaximal SET...
October 2016: Veterinary Journal
Cornelia Volland, Sebastian Bremer, Kristian Hellenkamp, Nico Hartmann, Nataliya Dybkova, Sara Khadjeh, Anna Kutschenko, David Liebetanz, Stefan Wagner, Bernhard Unsöld, Michael Didié, Karl Toischer, Samuel Sossalla, Gerd Hasenfuß, Tim Seidler
TBC1D10C is a protein previously demonstrated to bind and inhibit Ras and Calcineurin. In cardiomyocytes, also CaMKII is inhibited and all three targeted enzymes are known to promote maladaptive cardiomyocyte hypertrophy. Here, in accordance with lack of Calcineurin inhibition in vivo, we did not observe a relevant anti-hypertrophic effect despite inhibition of Ras and CaMKII. However, cardiomyocyte-specific TBC1D10C overexpressing transgenic mice exhibited enhanced longevity. Ejection fraction and exercise capacity were enhanced in transgenic mice, but shortening of isolated cardiomyocytes was not increased...
September 26, 2016: Scientific Reports
Tommi Sliiden, Sara Beck, Ian MacDonald
OBJECTIVES: Breathing strategies for athletic dancing are quite different from those needed for legato singing. This study considers the respiration data recorded by a telemetric heart rate monitor, mask, and gas analyzer collected from 20 musical theater professionals performing set tasks. METHODS: Scores were taken of maximum phonation time (MPT), relative oxygen uptake, and heart rate immediately after three tasks: (1) singing only, (2) dancing only, and (3) singing while dancing...
September 22, 2016: Journal of Voice: Official Journal of the Voice Foundation
Maria Amat-Foraster, Steven C Leiser, Kjartan F Herrik, Nelly Richard, Claus Agerskov, Christoffer Bundgaard, Jesper F Bastlund, Inge E M de Jong
The 5-HT6 receptor is a promising target for cognitive disorders, in particular for Alzheimer's disease (AD). The high affinity and selective 5-HT6 receptor antagonist idalopirdine (Lu AE58054) is currently in development for mild-moderate AD as adjunct therapy to acetylcholinesterase inhibitors (AChEIs). We studied the effects of idalopirdine alone and in combination with the AChEI donepezil on cortical function using two in vivo electrophysiological methods. Neuronal network oscillations in the frontal cortex were measured during electrical stimulation of the brainstem nucleus pontis oralis (nPO) in the anesthetized rat and by an electroencephalogram (EEG) in the awake, freely moving rat...
September 16, 2016: Neuropharmacology
James M Barber, Catherine J Pringle, Helen Raffalli-Ebezant, Omar Pathmanaban, Roberto Ramirez, Ian D Kamaly-Asl
Intracranial pressure (ICP) measurement is an important diagnostic tool in Neurosurgery. Until relatively recently, conventional monitoring has required that subjects be admitted to a hospital bed and the device is only able to be left in-situ for limited periods of time. We have evaluated a Telemetric ICP monitoring system that has been proven, by several other groups worldwide, to permit rapid, repeated and prolonged ICP measurement, in multiple environments. In our unit, 4 patients have been implanted to-date, between the ages of 4 and 16, manifesting a wide range of complex neurosurgical conditions...
September 19, 2016: British Journal of Neurosurgery
M A Oyama, M J Hezzell, D S Laughlin, C L Thorn, M S Kraus, A R Gelzer
Management of symptomatic bradyarrhythmias such as complete atrioventricular block often involves permanent implantation of a transvenous pacemaker. Both during and after implantation, the operator can telemetrically assess and adjust a variety of electrical parameters associated with the pacemaker function in order to optimize the sensitivity, reliability, and power consumption of the device. Herein, we report an unexpected change in the paced electrocardiographic QRS complex morphology in two dogs undergoing bipolar pacing associated with changes in the pacemaker output amplitude settings first detected during threshold testing...
September 6, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Jessica L Yorzinski
Even when animals are actively monitoring their environment, they lose access to visual information whenever they blink. They can strategically time their blinks to minimize information loss and improve visual functioning but we have little understanding of how this process operates in birds. This study therefore examined blinking in freely-moving peacocks (Pavo cristatus) to determine the relationship between their blinks, gaze shifts, and context. Peacocks wearing a telemetric eye-tracker were exposed to a taxidermy predator (Vulpes vulpes) and their blinks and gaze shifts were recorded...
2016: Scientific Reports
Barberis Antonio, Garbetta Antonella, Cardinali Angela, Bazzu Gianfranco, D 'Antuono Isabella, Rocchitta Gaia, Fadda Angela, Linsalata Vito, D 'Hallewin Guy, Serra Pier Andrea, Minervini Fiorenza
An integrated device for real-time monitoring of glucose and phenols absorption, that consists of a sensors/biosensors system (SB) and a Caco-2TC7 human intestinal cell culture, is described in this study. The SB is composed of a glucose oxidase-based biosensor, a sentinel platinum sensor, a laccase/tyrosinase-based biosensor and a sentinel carbon sensor, all located in the basolateral compartment (BC) of a cell culture plate. Caco-2TC7 cells, differentiated on culture inserts, separated the apical compartment that simulates the intestinal lumen, from the BC which represented the bloodstream...
August 3, 2016: Biosensors & Bioelectronics
S A Immanuel, A Sadrieh, M Baumert, J P Couderc, W Zareba, A P Hill, J I Vandenberg
Long QT syndrome (LQTS) is an inherited disorder associated with prolongation of the QT/QTc interval on the surface electrocardiogram (ECG) and a markedly increased risk of sudden cardiac death due to cardiac arrhythmias. Up to 25% of genotype-positive LQTS patients have QT/QTc intervals in the normal range. These patients are, however, still at increased risk of life-threatening events compared to their genotype-negative siblings. Previous studies have shown that analysis of T-wave morphology may enhance discrimination between control and LQTS patients...
September 2016: Physiological Measurement
Xiaoling Wang, Chuoyue Cheng, Chunling Ge, Bing Wang, Ye-Hua Gan
PURPOSE: To assess the acidogenic potential of eight different types of baked nuts or seeds eaten alone and after a sucrose challenge using in-dwelling electrode telemetry. METHODS: Six participants wearing a mandibular partial prosthesis incorporated with a miniature glass pH electrode were enrolled. The plaque pH was measured after 5 or 6 days of plaque accumulation. To establish a control, the subjects were instructed to rinse with sucrose, without any subsequent treatment, at the first visit...
June 2016: American Journal of Dentistry
Salwa Al-Noori, Douglas S Ramsay, Andreas Cimpan, Zoe Maltzer, Jessie Zou, Karl J Kaiyala
Initial administration of ≥60% nitrous oxide (N2O) to rats promotes hypothermia primarily by increasing whole-body heat loss. We hypothesized that the drug promotes heat loss via the tail and might initially inhibit thermogenesis via brown adipose tissue (BAT), major organs of thermoregulation in rodents. Following repeated administrations, N2O inhalation evokes hyperthermia underlain by increased whole-body heat production. We hypothesized that elevated BAT thermogenesis plays a role in this thermoregulatory sign reversal...
August 2016: Journal of Thermal Biology
Sarah H Wild, Janet Hanley, Stephanie C Lewis, John A McKnight, Lucy B McCloughan, Paul L Padfield, Richard A Parker, Mary Paterson, Hilary Pinnock, Aziz Sheikh, Brian McKinstry
BACKGROUND: Self-monitoring of blood glucose among people with type 2 diabetes not treated with insulin does not appear to be effective in improving glycemic control. We investigated whether health professional review of telemetrically transmitted self-monitored glucose results in improved glycemic control in people with poorly controlled type 2 diabetes. METHODS AND FINDINGS: We performed a randomized, parallel, investigator-blind controlled trial with centralized randomization in family practices in four regions of the United Kingdom among 321 people with type 2 diabetes and glycated hemoglobin (HbA1c) >58 mmol/mol...
July 2016: PLoS Medicine
Jordan Squair, Christopher R West, David Popok, Peggy Assinck, Jie Liu, Wolfram Tetzlaff, Andrei V Krassioukov
Cardiovascular disease is the leading cause of death for individuals with spinal cord injury (SCI). Due to a lack of a standardized and accessible animal model for cardiovascular disease after SCI, few laboratories have conducted pre-clinical trials aimed at re-instating descending cardiovascular control. Here, we utilized common contusion methodology applied to the midline of the upper-thoracic cord of adult Wistar rats accompanied with telemetric blood pressure monitoring, Fluorogold retrograde neuronal tracing, as well as lesion site and lumbrosacral afferent immunohistochemistry...
July 25, 2016: Journal of Neurotrauma
Siegfried Mariacher, Martina Ebner, Kai Januschowski, José Hurst, Sven Schnichels, Peter Szurman
Intraocular Pressure (IOP) is an important and modifiable risk factor for glaucoma progression. IOP fluctuations and spikes often remain undetected despite clinical routine examinations. Therefore telemetric IOP measurement systems with continuous IOP monitoring can provide major advantages in glaucoma surveillance. To the best of our knowledge, this is the first study to investigate implantable telemetric suprachoroidal IOP sensors. Six novel telemetric pressure transducers were implanted in the suprachoroidal space of 6 eyes from 6 New Zealand White rabbits...
October 2016: Experimental Eye Research
Ronald Biemann, Marina Penner, Katrin Borucki, Sabine Westphal, Claus Luley, Raik Rönicke, Kathleen Biemann, Cornelia Weikert, Anke Lux, Nikolai Goncharenko, Hanns-Ulrich Marschall, Jochen G Schneider, Berend Isermann
Bile acids (BAs) are increasingly recognised as metabolic regulators, potentially improving insulin sensitivity following bariatric surgery. However, physiological relevance of such observations remains unknown. Hence, we analysed serum BA composition and associated gut-derived hormone levels following lifestyle-induced weight loss in individuals with metabolic syndrome (MetS). 74 non-smoking men (45-55 yr) with MetS were randomised to a lifestyle-induced weight loss program (supervision via telemonitoring) or to a control arm...
2016: Scientific Reports
Manuel Hernando Rydings, Pilar Marín Palacios, Ana M Aragón-Sánchez, Esther Bravo Ruiz, Victor Lopez-Dominguez, Isaac Martínez López, Cristina Fernández Pérez, Amaia Bilbao González, Francisco Javier Serrano Hernando, Reyes Vega Manrique, Antonio Hernando Grande
BACKGROUND: Because of the unique electromagnetic characteristics of the magnetoelastic microwire, the changes in the pressure of a fluid will provoke a variation of the mechanical pressure on the sensor, which will cause a variation of its magnetization that will be detectable wirelessly. Thus, a wireless system can be developed for following up vascular surgery procedures. METHODS AND RESULTS: The sensor consists of a magnetoelastic microwire ring, which was integrated into an in vitro model with pulsatile flow...
2016: Journal of the American Heart Association
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