keyword
MENU ▼
Read by QxMD icon Read
search

CIRCI

keyword
https://www.readbyqxmd.com/read/27449593/comparison-of-the-chondroprotective-effect-of-a-novel-hydrogel-compound-and-traditional-hyaluronate-on-rat-cartilage-in-a-papain-induced-osteoarthritis-model
#1
Erhan Şükür, Canan Talu, Yunus Emre Akman, Esra Çirci, Yusuf Öztürkmen, Tolga Tüzüner
PURPOSE: The aim of this experimental study is to evaluate the efficacy of a novel intraarticular drug in a papain induced osteoarthritis (OA) rat model and compare with the traditional hyaluronat (HA) visco supplementation. METHODS: An early stage OA model was induced by the intra-articular injection of papain enzyme in the right knee joints of 44 Sprague-Dawley rats. Eleven rats (eleven right knees: papain group, 11 left knees: control group) were chosen randomly 28 days after the last injection and sacrificed for verifying OA...
August 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27255589/metatarsal-head-resurfacing-arthroplasty-in-the-treatment-of-hallux-rigidus-is-it-reliable-treatment-option
#2
E Circi, T Tuzuner, E Sukur, A Baris, E Kanay
BACKGROUND: This study looks at the failure and complications arising secondary to resurfacing and hemi-arthroplasty done at the metatarsal head in patients with hallux rigidus. Our report includes a review of the relevant literature to verify the validity of our techniques. MATERIALS AND METHODS: We performed metatarsal head resurfacing with hemi-arthroplasty using the HemiCap(®), on 12 patients with hallux rigidus between the dates of March 2010 and October 2013...
August 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27130398/locked-hip-joint-an-uncommon-presentation-of-localized-pigmented-villonodular-synovitis
#3
Tahsin Beyzadeoğlu, Esra Çirci
We report a 24-year-old male who was admitted to the emergency department with an unusual complaint of locked hip joint. Magnetic resonance imaging (MRI) showed a 3-cm intra-articular synovial nodular mass and a 3.0x2.4x1.6-cm yellow-brownish colored pediculed synovial nodular mass was excised with hip arthroscopy. Pathological examination confirmed the diagnosis of pigmented villonodular synovitis. Excision of the mass allowed prompt resolution of the symptoms and there was no sign of recurrence at 3-year follow-up...
2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27130396/impact-of-platelet-rich-plasma-injection-timing-on-healing-of-achilles-tendon-injury-in-a-rat-model
#4
Esra Çirci, Yunus Emre Akman, Erhan Şükür, Erol Rüştü Bozkurt, Tolga Tüzüner, Yusuf Öztürkmen
OBJECTIVE: The aim of this study was to evaluate the impact of the timing of platelet-rich plasma (PRP) application on the healing of Achilles tendon injury in a rat model. METHODS: Fifty-four female Sprague-Dawley rats were divided into 4 groups: PRP preparation group (n=6); Achilles tendon tear and 150 µL of PRP received on the day following the injury (PRP day 0, group 1, n=16); Achilles tendon tear and 150 µL of PRP received on the third day following injury (day 3 , group 2, n=16); Achilles tendon tear and 150 µL of saline received on the day following injury (PRP day 0, group 3, n=16)...
2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27059746/diagnosis-and-management-of-pediatric-adrenal-insufficiency
#5
REVIEW
Ahmet Uçar, Firdevs Baş, Nurçin Saka
BACKGROUND: Adrenal insufficiency (AI) is a wellknown cause of potentially life-threatening disorders. Defects at each level of the hypothalamic-pituitary-adrenal axis can impair adrenal function, leading to varying degrees of glucocorticoid (GC) deficiency. Iatrogenic AI induced by exogenous GCs is the most common cause of AI. The criteria for the diagnosis and management of iatrogenic AI, neonatal AI, and critical illness-related corticosteroid insufficiency (CIRCI) are not clear. DATA SOURCES: We reviewed the recent original publications and classical data from the literature, as well as the clinical, diagnostic and management strategies of pediatric AI...
August 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/26762346/simultaneous-acl-pcl-reconstructions-with-high-tibial-osteotomy-salvage-for-an-unstable-arthritic-knee
#6
Tahsin Beyzadeoglu, Murat Demirel, Esra Circi
We present a case of a 28-year-old man with a severe osteoarthritic varus knee after a neglected multiligamentous injury sustained 10 years prior. Simultaneous anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) reconstructions with high tibial osteotomy (HTO) were performed at a single stage. Five years after surgery, there were no signs of effusion and no instability, and the patient could easily kneel down without any discomfort. We think that salvage procedures and biological reconstructions would be the primary choice of surgical treatment in young patients to delay arthroplasty, and it is possible to perform simultaneous reconstructions of ACL and PCL with HTO in a single stage...
January 13, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26665050/superior-labrum-anterior-posterior-lesions-and-associated-injuries-return-to-play-in-elite-athletes
#7
Tahsin Beyzadeoglu, Esra Circi
BACKGROUND: Superior labrum anterior posterior (SLAP) lesions often cause shoulder pain, dysfunction, and instability. Professional athletes require a high level of shoulder function for competition and overhead activities. PURPOSE: To evaluate elite athletes who had arthroscopic surgery for common shoulder pathologies and SLAP lesions with a follow-up of more than 3 years. The associated intra-articular pathologies and return to play were documented. STUDY DESIGN: Case series; Level of evidence, 4...
April 2015: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/26511692/modified-simmonds-menelaus-procedure-for-moderate-or-severe-adult-hallux-valgus
#8
Yunus Emre Akman, Merter Yalçınkaya, Esra Çirçi, Yunus Atıcı, Yusuf Öztürkmen, Ahmet Doğan
OBJECTIVE: The purpose of this study was to present the clinical and radiological results of modified Simmonds-Menelaus technique, performed as a proximal, medially-based, open-wedge osteotomy of the first metatarsal, in cases of moderate or severe adult hallux valgus deformity. METHODS: Fifty-one feet of 47 patients underwent surgery due to hallux valgus. Mean age was 41.2±14.0 years, and mean follow-up period was 99.5±36.0 months. Patients were evaluated with standing anteroposterior (AP) and lateral radiographies obtained in the preoperative and early postoperative periods, and during final follow-up...
2015: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/26273697/dynamic-and-structural-performances-of-a-new-sailcraft-concept-for-interplanetary-missions
#9
Alessandro Peloni, Daniele Barbera, Susanna Laurenzi, Christian Circi
Typical square solar-sail design is characterised by a central hub with four-quadrant sails, conferring to the spacecraft the classical X-configuration. One of the critical aspects related to this architecture is due to the large deformations of both membrane and booms, which leads to a reduction of the performance of the sailcraft in terms of thrust efficiency. As a consequence, stiffer sail architecture would be desirable, taking into account that the rigidity of the system strongly affects the orbital dynamics...
2015: TheScientificWorldJournal
https://www.readbyqxmd.com/read/25802564/effect-of-low-dose-glucocorticoid-on-corticosteroid-insufficient-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#10
Wei-Ping Sun, Guang-Xiong Yuan, Yan-Juan Hu, Li-Zhen Liao, Lin Fu
BACKGROUND: This study aimed to investigate the prevalence rate of critical illness-related corticosteroid insufficiency (CIRCI) and the effect of low-dose glucocorticoid on prognosis of CIRCI in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). METHODS: Since January 2010 to December 2012, 385 patients, who met the criteria of AECOPD, were enrolled in the Intensive Care Unit (ICU) of the First People's Hospital and Municipal Central Hospital of Xiangtan City...
2015: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25560635/diminished-adrenal-sensitivity-to-endogenous-and-exogenous-adrenocorticotropic-hormone-in-critical-illness-a-prospective-cohort-study
#11
Margriet F C de Jong, Nienke Molenaar, Albertus Beishuizen, A B Johan Groeneveld
INTRODUCTION: Adrenal dysfunction may represent critical illness-related corticosteroid insufficiency (CIRCI), as evidenced by a diminished cortisol response to exogenous adrenocorticotropic hormone (ACTH), but this concept and its clinical significance remain highly controversial. We studied the adrenal response to exogenous ACTH as a function of the endogenous cortisol-to-ACTH ratio, a measure of adrenal sensitivity, and of clinical variables, during critical illness and recovery from the acute phase...
2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25516097/controversies-surrounding-critical-illness-related-corticosteroid-insufficiency-in-animals
#12
REVIEW
Jamie M Burkitt Creedon
OBJECTIVES: To describe the controversies surrounding critical illness-related corticosteroid insufficiency (CIRCI) and the use of hydrocortisone in critically ill patients, and to present published diagnostic and therapeutic strategies in companion veterinary species. ETIOLOGY: Critical illness-related corticosteroid insufficiency may be due to hypothalamic-pituitary-adrenal (HPA) axis dysfunction, alterations in cortisol-plasma protein binding, target cell enzymatic changes, changes in glucocorticoid receptor (GR) function, or a combination of these or other factors present during critical illness...
January 2015: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/25055003/suspected-adrenal-insufficiency-in-critically-ill-burned-patients-etomidate-induced-or-critical-illness-related-corticosteroid-insufficiency-a-review-of-the-literature
#13
REVIEW
Michael J Mosier, Alaina M Lasinski, Richard L Gamelli
Adrenal insufficiency (AI), whether etomidate-induced or secondary to critical illness-related corticosteroid insufficiency (CIRCI), is a common and under appreciated problem in the intensive care unit intensive care unit (ICU). However, AI is often difficult to identify and diagnose in the critically ill. The pathophysiology and ideal management of etomidate-induced AI and CIRCI, especially in burn patients, is unknown. Many studies, however, have examined the prevalence of and risk factors for developing AI in critically ill populations as well as the effect of AI on morbidity and mortality...
March 2015: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/24819916/the-incidence-of-critical-illness-related-corticosteroid-insufficiency-is-associated-with-severity-of-traumatic-brain-injury-in-adult-rats
#14
Xin Chen, Zilong Zhao, Yan Chai, Lanlan Luo, Rongcai Jiang, Jianning Zhang
Traumatic brain injury (TBI) causes deleterious critical-illness-related-corticosteroid-insufficiency (CIRCI), leading to high mortality and morbidity. However, the incidence of CIRCI following different TBI severities is not fully defined. This study was designed to investigate mechanistically the effects of injury severity on corticosteroid response and the development of CIRCI in a rat model of experimentally controlled TBI. Adult male Wistar rats were randomly assigned to sham, mild injury, moderate injury or severe injury groups...
July 15, 2014: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/24747037/measurement-of-the-glucocorticoid-receptor-relevance-to-the-diagnosis-of-critical-illness-related-corticosteroid-insufficiency-in-children
#15
REVIEW
Rahul Bhatia, Jonathan Muraskas, Linda Witek Janusek, Herbert Mathews
Diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in children continues to remain difficult and controversial in that no consensus for either exists among pediatric critical care physicians. Critical illness-related corticosteroid insufficiency is defined as a corticosteroid response that is inadequate for the severity of the illness experienced by the patient. Critical illness-related corticosteroid insufficiency manifests as an insufficient corticosteroid mediated down-regulation of proinflammatory cytokines, due to either corticosteroid tissue resistance and/or inadequate circulating levels of cortisol...
August 2014: Journal of Critical Care
https://www.readbyqxmd.com/read/24217117/critical-illness-related-corticosteroid-insufficiency-in-children
#16
REVIEW
Yael Levy-Shraga, Orit Pinhas-Hamiel
Adequate adrenocortical function is essential for survival in critical illness. Most critically ill patients display elevated plasma cortisol concentrations, which reflects activation of the hypothalamic-pituitary-adrenal axis and is considered to be a homeostatic adaptation. However, many critically ill patients have 'relative' or 'functional' adrenal insufficiency, which is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress. Recently, the term 'critical illness-related corticosteroid insufficiency' (CIRCI) was coined...
2013: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/24131855/stress-dose-hydrocortisone-reduces-critical-illness-related-corticosteroid-insufficiency-associated-with-severe-traumatic-brain-injury-in-rats
#17
Xin Chen, Zilong Zhao, Yan Chai, Lanlan Luo, Rongcai Jiang, Jingfei Dong, Jianning Zhang
INTRODUCTION: The spectrum of critical illness-related corticosteroid insufficiency (CIRCI) in severe traumatic brain injury (TBI) is not fully defined and no effective treatments for TBI-induced CIRCI are available to date. Despite growing interest in the use of stress-dose hydrocortisone as a potential therapy for CIRCI, there remains a paucity of data regarding its benefits following severe TBI. This study was designed to investigate the effects of stress-dose hydrocortisone on CIRCI development and neurological outcomes in a rat model of severe traumatic brain injury...
2013: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/24112177/effects-of-glucocorticoids-on-traumatic-brain-injury-related-critical-illness-related-corticosteroid-insufficiency
#18
Zi-long Zhao, Xin Chen, Hui Zhu, Bao-liang Zhang, Yan Chai, Xin-yuan Li, Jing-fei Dong, Jian-ning Zhang
BACKGROUND: Traumatic brain injury (TBI) is a heterogeneous condition that can lead to critical LLLness-related corticosteroid insufficiency (CIRCI) causing a high mortality and morbidity. Glucocorticoids were widely used in the clinical management of TBI, but their benefit has been challenged in some studies and their efficacy, especially for treating CIRCI in TBI patients, remains unclear. METHODS: We conducted a meta-analysis of published data to determine if the controversy is related to clinical dosing and timing of glucocorticoids (GCs) application...
2013: Chinese Medical Journal
https://www.readbyqxmd.com/read/24103812/high-dose-glucocorticoid-aggravates-tbi-associated-corticosteroid-insufficiency-by-inducing-hypothalamic-neuronal-apoptosis
#19
Hui Zhu, Zilong Zhao, Yuan Zhou, Xin Chen, Ying Li, Xiao Liu, Hujie Lu, Yanjun Zhang, Jianning Zhang
Emerging experimental and clinical data suggest that severe illness, such as traumatic brain injury (TBI), can induce critical illness-related corticosteroid insufficiency (CIRCI). However, underlying mechanisms of this TBI-associated CIRCI remain poorly understood. We hypothesized that dexamethasone (DXM), a synthetic glucocorticoid, which was widely used to treat TBI, induces hypothalamic neuronal apoptosis to aggravate CIRCI. To test this hypothesis, we have evaluated the dose effect of DXM (1 or 10mg/kg) on the development of acute CIRCI in rats with fluid percussion injury-induced TBI and on cultured rat hypothalamic neurons in vitro (DXM, 10(-5)-10(-8)mol/L)...
December 6, 2013: Brain Research
https://www.readbyqxmd.com/read/23999515/the-effects-of-extracorporeal-shock-waves-on-carrageenan-induced-achilles-tendinitis-in-rats-a-biomechanical-and-histological-analysis
#20
Bekir Murat Çınar, Esra Çirci, Cenk Balçık, Gülnur Güven, Sercan Akpınar, Alihan Derincek
OBJECTIVE: The aim of this study was to investigate the influence of low-dose extracorporeal shock waves (ESW) on the healing potential of Achilles tendinitis in the rat. METHODS: The 36 adult Sprague-Dawley rats used in this study were randomly divided into four groups. Group A (n=10) were injected with carrageenan, Group B (n=10) were injected with carrageenan and received ESW, Group C (n=10) received ESW only, and Group D (n=6) was a sham group. Rats were injected with 10 microliters of 3% carrageenan or a saline solution eight times during a one-week period with a subcutaneous needle...
2013: Acta Orthopaedica et Traumatologica Turcica
keyword
keyword
8498
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"