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JOURNAL ARTICLE
Vincent Pey, Emmanuel Doumard, Matthieu Komorowski, Antoine Rouget, Clément Delmas, Fanny Vardon-Bounes, Michaël Poette, Valentin Ratineau, Cédric Dray, Isabelle Ader, Vincent Minville
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) represents a major burden for society and health care, with an average incidence in adults of 67 to 170 cases per 100,000 person-years in Europe and in-hospital survival rates of less than 10%. Patients and practitioners would benefit from a prognostication tool for long-term good neurological outcomes. OBJECTIVE: We aim to develop a machine learning (ML) pipeline on a local database to classify patients according to their neurological outcomes and identify prognostic features...
2024: Digital Health
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JOURNAL ARTICLE
Yosuke Kimura, Yoshiki Suzuki, Marie Abe
Objectively measured physical activity volume serves as a predictive factor for functional recovery in patients with stroke. Malnutrition, a frequent complication of stroke, may influence the relationship between physical activity and functional recovery. This study aimed to examine the association between physical activity volume and functional recovery in patients with stroke, stratified by their nutritional status. This multicenter prospective observational study included 209 patients with stroke admitted to two Japanese convalescent rehabilitation hospitals...
April 15, 2024: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
#3
JOURNAL ARTICLE
Mai Shi, Aimin Yang, Eric S H Lau, Andrea O Y Luk, Ronald C W Ma, Alice P S Kong, Raymond S M Wong, Jones C M Chan, Juliana C N Chan, Elaine Chow
BACKGROUND: Older adults with diabetes are at high risk of severe hypoglycemia (SH). Many machine-learning (ML) models predict short-term hypoglycemia are not specific for older adults and show poor precision-recall. We aimed to develop a multidimensional, electronic health record (EHR)-based ML model to predict one-year risk of SH requiring hospitalization in older adults with diabetes. METHODS AND FINDINGS: We adopted a case-control design for a retrospective territory-wide cohort of 1,456,618 records from 364,863 unique older adults (age ≥65 years) with diabetes and at least 1 Hong Kong Hospital Authority attendance from 2013 to 2018...
April 2024: PLoS Medicine
#4
JOURNAL ARTICLE
Xiao Tang, Xiao-Li Xu, Na Wan, Yu Zhao, Rui Wang, Xu-Yan Li, Ying Li, Li Wang, Hai-Chao Li, Yue Gu, Chun-Yan Zhang, Qi Yang, Zhao-Hui Tong, Bing Sun
INTRODUCTION: Systematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS). METHOD: This was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument...
2024: Frontiers in Cellular and Infection Microbiology
#5
MULTICENTER STUDY
Isabelle Arctaedius, Helena Levin, Bergthóra Thorgeirsdóttir, Marion Moseby-Knappe, Tobias Cronberg, Martin Annborn, Niklas Nielsen, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Attila Frigyesi, Hans Friberg, Anna Lybeck, Niklas Mattsson-Carlgren
BACKGROUND: The purpose was to evaluate glial fibrillary acidic protein (GFAP) and total-tau in plasma as predictors of poor neurological outcome after out-of-hospital (OHCA) and in-hospital cardiac arrest (IHCA), including comparisons with neurofilament light (NFL) and neuron-specific enolase (NSE). METHODS: Retrospective multicentre observational study of patients admitted to an intensive care unit (ICU) in three hospitals in Sweden 2014-2018. Blood samples were collected at ICU admission, 12 h, and 48 h post-cardiac arrest...
April 9, 2024: Critical Care: the Official Journal of the Critical Care Forum
#6
JOURNAL ARTICLE
Lingde Kong, Hua Li, Yanqing Zhou, Bing Zhang, Quan Han, Meng Fu
OBJECTIVE: This study aimed to determine the incidence and predictors of the complications after open reduction and internal fixation (ORIF) of intra-articular distal radius fracture (IADRF) with a minimum follow-up of 12 months. METHODS: Medical records and outpatient follow-up records were retrospectively reviewed to collect medical, surgical, and complication data on consecutive patients who had undergone an ORIF procedure for an IADRF between January 2019 and June 2022...
2024: Frontiers in Surgery
#7
JOURNAL ARTICLE
Maria Wobith, Markus Lurz, Arved Weimann
INTRODUCTION: For diagnosing malnutrition as an important modifiable risk factor in surgical cancer patients, GLIM criteria offer a standardised diagnostic pathway. Before assessing malnutrition it is suggested to screen for malnutrition with an implemented screening tool, i.e. the NRS-2002. Validated data regarding the applied screening tool and its relevance for predicting outcome parameters in surgical patients is sparse. METHODS: 260 patients undergoing major abdominal surgery for cancer were retrospectively analysed...
April 5, 2024: Annals of Nutrition & Metabolism
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JOURNAL ARTICLE
Lukas Kellermair, Christoph Höfer, Matthias W G Zeller, Christa Kubasta, Dave Bandke, Serge Weis, Jörg Kellermair, Thomas Forstner, Raimund Helbok, Milan R Vosko
BACKGROUND AND PURPOSE: Cerebral sinus venous thrombosis (CSVT) is a rare but life-threatening disease and its diagnosis remains challenging. Blood biomarkers, including D-Dimer are currently not recommended in guidelines. Soluble endothelial receptor proteins (sICAM-1, sPECAM-1 and sVCAM-1) have been shown to be promising diagnostic biomarkers in deep vein thrombosis (DVT) and pulmonary embolism (PE). Therefore, we examined endothelial receptor proteins as potential biomarkers for detecting CSVT...
April 5, 2024: Journal of Neurology
#9
JOURNAL ARTICLE
Hannah C Barca, Jeannette Ferber, Megan Richards, Matthew Strickland, Alfred J Fernandez, De-Kun Li, Lyndsey A Darrow
BACKGROUND: To describe temporal and sociodemographic patterns of antimicrobial exposure during the first year of life in a large US cohort. METHODS: Singleton infants born 1998-2014 enrolled in Kaiser Permanente Northern California integrated health system (n = 345,550) were followed longitudinally via comprehensive electronic health records, capturing all systemic antimicrobial inpatient administrations and outpatient dispensings. Antimicrobial exposure was summarized by maternal and infant characteristics, birth year, inpatient/outpatient status, age in months, and drug class...
April 3, 2024: Pediatric Research
#10
JOURNAL ARTICLE
Chao Chen, Shengqi Li, Fangyue Sun, Yiqun Chen, Haojie Qiu, Jiaqi Huang, Yining Jin, Jiexi Huang, Jiahan Xu, Zerui Jiang, Kun Li, Yanchu Wang, Hai Lin
The neutrophil to apolipoprotein A1 ratio has emerged as a possible prognostic biomarker in different medical conditions. Nonetheless, the predictive potential of neutrophil to apolipoprotein A1 ratio in determining the 3-month prognosis of acute ischaemic stroke patients who undergo intravenous thrombolysis has yet to be fully acknowledged. In this study, 196 acute ischaemic stroke patients with recombinant tissue plasminogen activator and 133 healthy controls were included. Meanwhile, we incorporated a total of 386 non-thrombolytic acute ischaemic stroke patients...
2024: Brain communications
#11
JOURNAL ARTICLE
Radu Vatasescu, Cosmin Cojocaru, Viviana Gondos, Corneliu Iorgulescu, Stefan Bogdan, Sebastian Onciul, Antonio Berruezo
INTRODUCTION: Prognosis after electrical storm (ES) ablation remains severe, especially in patients with recurrent sustained monomorphic ventricular tachycardia (SMVT) or progressive heart failure (HF). However, single-factor-based prediction is suboptimal and may be refined by more complex algorithms. We sought to evaluate if a novel score MSA-VT (M = moderate/severe mitral regurgitation, S = severe HF at admission, A = atrial fibrillation at admission, VT = inducible SMVT after ablation) may improve prediction of death and recurrences compared to single factors and previous scores (PAINESD, RIVA and I-VT)...
February 22, 2024: Biomedicines
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JOURNAL ARTICLE
Andreas Filis, Kay Engellandt, Sergio M F Romualdo, Ibrahim El-Battrawy, Dino Podlesek, Tareq A Juratli, Ilker Y Eyüpoglu, Mido Max Hijazi
BACKGROUND: Successful treatment of spinal dural arteriovenous fistulas (SDAVF) requires prompt diagnosis with definitive fistula localization and non-delayed treatment. Magnetic resonance imaging (MRI) is used for the screening and follow-up of SDAVF, although the value of MRI signs such as myelopathy and flow voids is controversial. Therefore, we investigated the predictive value of MRI signs pre- and post-treatment and their correlation with the neurological status of SDAVF patients...
March 8, 2024: Diagnostics
#13
JOURNAL ARTICLE
Clare Fong, Wern Lunn Kueh, Sennen Jin Wen Lew, Benjamin Choon Heng Ho, Yu-Lin Wong, Yie Hui Lau, Yew Woon Chia, Hui Ling Tan, Ying Hao Christopher Seet, Wen Ting Siow, Graeme MacLaren, Rohit Agrawal, Tian Jin Lim, Shir Lynn Lim, Toon Wei Lim, Vui Kian Ho, Chai Rick Soh, Duu Wen Sewa, Chian Min Loo, Faheem Ahmed Khan, Chee Keat Tan, Roshni Sadashiv Gokhale, Chuin Siau, Noelle Louise Siew Hua Lim, Chik-Foo Yim, Jonathen Venkatachalam, Kumaresh Venkatesan, Naville Chi Hock Chia, Mei Fong Liew, Guihong Li, Li Li, Su Mon Myat, Zena Zena, Shuling Zhuo, Ling Ling Yueh, Caroline Shu Fang Tan, Jing Ma, Siew Lian Yeo, Yiong Huak Chan, Jason Phua
BACKGROUND: Clinical practice guidelines on limitation of life-sustaining treatments (LST) in the intensive care unit (ICU), in the form of withholding or withdrawal of LST, state that there is no ethical difference between the two. Such statements are not uniformly accepted worldwide, and there are few studies on LST limitation in Asia. This study aimed to evaluate the predictors and outcomes of withholding and withdrawal of LST in Singapore, focusing on the similarities and differences between the two approaches...
March 26, 2024: Journal of Intensive Care
#14
JOURNAL ARTICLE
Żaneta Chatys-Bogacka, Iwona Mazurkiewicz, Joanna Słowik, Agnieszka Słowik, Leszek Drabik, Marcin Wnuk
BACKGROUND: To evaluate incidence and search for possible predictors of brain fog and quality of life at work (QoL-W) among low-to-moderate risk subjects previously hospitalized due to COVID-19. MATERIAL AND METHODS: Participants aged ≥18 retrospectively reported 8 brain fog symptoms pre-COVID-19, at 0-4, 4-12 and >12 weeks post-infection via validated clinical questionnaire. The QoL-W was assessed with a 4-point Likert scale where 0, 1, 2, and 3 meant no, mild, moderate, and severe impairment in performing activities at work, respectively...
March 22, 2024: Medycyna Pracy
#15
JOURNAL ARTICLE
Juan Wang, Xiaoting Chen, Siqi He, Jing Li, Tianyuan Ma, Lu Liu, Lei Zhang, Xiaoning Bu
INTRODUCTION: Readmission following bronchiectasis exacerbation is a common and challenging clinical problem and few simple predictive tools exist. The COPD Assessment Test (CAT) is an easy-to-use questionnaire. This study aims to evaluate the predictive value of CAT scores in determining the risk of readmission in patients with bronchiectasis exacerbation. METHODS: We conducted a prospective cohort study in 106 bronchiectasis patients admitted with exacerbation...
March 2024: ERJ Open Research
#16
JOURNAL ARTICLE
Peter Wohlfahrt, Dominik Jenča, Vojtěch Melenovský, Josef Stehlik, Jolana Mrázková, Marek Šramko, Martin Kotrč, Michael Želízko, Věra Adámková, Jan Piťha, Josef Kautzner
AIMS: While heart failure (HF) symptoms are associated with adverse prognosis after myocardial infarction (MI), they are not routinely used for patients' stratification. The primary objective of this study was to develop and validate a score to predict mortality risk after MI, combining remotely recorded HF symptoms and clinical risk factors, and to compare it against the guideline-recommended GRACE score. METHODS: A cohort study design using prospectively collected data from consecutive patients hospitalized for MI at a large tertiary heart centre between June 2017 and September 2022 was used...
March 18, 2024: European Journal of Preventive Cardiology
#17
JOURNAL ARTICLE
Christina Belza, Péter Szentkúti, Erzsébet Horváth-Puhó, Joel G Ray, Katherine E Nelson, Sonia M Grandi, Hilary K Brown, Henrik Toft Sørensen, Eyal Cohen
OBJECTIVE: To define major congenital anomaly subgroups and assess outcome variability based on defined subgroups. STUDY DESIGN: This population-based cohort study used registries in Denmark for children born with a major congenital anomaly between January 1997 and December 2016, with follow-up until December 2018. We performed a latent class analysis (LCA) using child and family clinical and sociodemographic characteristics present at birth, incorporating additional variables occurring until age of 24 months...
March 15, 2024: Journal of Pediatrics
#18
JOURNAL ARTICLE
Klara Friberg, Kristin Hofsø, Tone Rustøen, Johan Ræder, Milada Hagen, Kathleen Puntillo, Brita Fosser Olsen
BACKGROUND: Intensive care unit (ICU) patients are at risk of suffering from posttraumatic stress symptoms (PTSS) after ICU survival. OBJECTIVES: To describe the prevalence of high levels of PTSS the first year after ICU admission. Further, to identify specific combinations of patient characteristics (latent classes based on pre-ICU data, demographics, and clinical characteristics), and to investigate possible associations among these classes and PTSS at 3, 6, and 12 months after ICU admission...
March 15, 2024: Heart & Lung: the Journal of Critical Care
#19
JOURNAL ARTICLE
Nikolaos Pyrgidis, Gerald B Schulz, Yannic Volz, Benedikt Ebner, Severin Rodler, Thilo Westhofen, Lennert Eismann, Julian Marcon, Christian G Stief, Friedrich Jokisch
INTRODUCTION: Radical cystectomy (RC) is the gold standard for muscle-invasive bladder cancer. Nevertheless, RC is associated with substantial perioperative morbidity and mortality. We aimed to evaluate the role of important perioperative risk factors in predicting long-term survival after RC. METHODS: An analysis of the prospective cohort of patients undergoing open RC from 2004 to 2023 at our center was performed. Patients who died within one month after RC were excluded from the study...
March 15, 2024: World Journal of Urology
#20
RANDOMIZED CONTROLLED TRIAL
Mohamed G Zeinhom, Mohamed Fouad Elsayed Khalil, Islam Fathallah Mohamed Kamel, Ahmed Mohamed Kohail, Sherihan Rezk Ahmed, Ahmed Elbassiouny, Ashfaq Shuaib, Omar M Al-Nozha
Worldwide, stroke is a leading cause of long-term disability in adults. Alteplase is the only approved treatment for acute ischemic stroke (AIS) and results in an improvement in a third of treated patients. We evaluated the post-stroke unfavourable outcome predictors in alteplase-treated patients from Egypt and Saudi Arabia. We assessed the effect of different risk factors on AIS outcomes after alteplase in Egypt and Saudi Arabia. Our study included 592 AIS alteplase-treated patients. The relationship between risk factors, clinical presentation, and imaging features was evaluated to predict factors associated with poor outcomes...
March 12, 2024: Scientific Reports
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