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https://www.readbyqxmd.com/read/28092252/-accessibility-to-health-services-theoretical-debate-on-determinants-and-implications-in-the-public-health-policy
#1
Diana Alejandra Sánchez-Torres
This paper presents the theorical development of accesibility as process and product. The process consists of the elements that converge to meet the objectives of providing medical care in a timely manner. As product is a component of effective care. Accesibility itself is subject to a combination of economic, cultural, social, geographic and contextual aspects. Beyond the right of persons to receive health care, availability of institutions and the means to achieve.
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28091804/baseline-results-from-the-uk-signify-study-a-whole-body-mri-screening-study-in-tp53-mutation-carriers-and-matched-controls
#2
Sibel Saya, Emma Killick, Sarah Thomas, Natalie Taylor, Elizabeth K Bancroft, Jeanette Rothwell, Sarah Benafif, Alexander Dias, Christos Mikropoulos, Jenny Pope, Anthony Chamberlain, Ranga Gunapala, Louise Izatt, Lucy Side, Lisa Walker, Susan Tomkins, Jackie Cook, Julian Barwell, Vicki Wiles, Lauren Limb, Diana Eccles, Martin O Leach, Susan Shanley, Fiona J Gilbert, Helen Hanson, David Gallagher, Bala Rajashanker, Richard W Whitehouse, Dow-Mu Koh, S Aslam Sohaib, D Gareth Evans, Rosalind A Eeles
In the United Kingdom, current screening guidelines for TP53 germline mutation carriers solely recommends annual breast MRI, despite the wide spectrum of malignancies typically seen in this group. This study sought to investigate the role of one-off non-contrast whole-body MRI (WB MRI) in the screening of asymptomatic TP53 mutation carriers. 44 TP53 mutation carriers and 44 population controls were recruited. Scans were read by radiologists blinded to participant carrier status. The incidence of malignancies diagnosed in TP53 mutation carriers against general population controls was calculated...
January 16, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28091798/intake-of-up-to-3-eggs-day-increases-hdl-cholesterol-and-plasma-choline-while-plasma-trimethylamine-n-oxide-is-unchanged-in-a-healthy-population
#3
Diana M DiMarco, Amanda Missimer, Ana Gabriela Murillo, Bruno S Lemos, Olga V Malysheva, Marie A Caudill, Christopher N Blesso, Maria Luz Fernandez
Eggs are a source of cholesterol and choline and may impact plasma lipids and trimethylamine-N-oxide (TMAO) concentrations, which are biomarkers for cardiovascular disease (CVD) risk. Therefore, the effects of increasing egg intake (0, 1, 2, and 3 eggs/day) on these and other CVD risk biomarkers were evaluated in a young, healthy population. Thirty-eight subjects [19 men/19 women, 24.1 ± 2.2 years, body mass index (BMI) 24.3 ± 2.5 kg/m(2)] participated in this 14-week crossover intervention. Participants underwent a 2-week washout with no egg consumption, followed by intake of 1, 2, and 3 eggs/day for 4 weeks each...
January 13, 2017: Lipids
https://www.readbyqxmd.com/read/28091775/developmental-and-sex-specific-differences-in-expression-of-neuropeptides-derived-from-allatotropin-gene-in-the-silkmoth-bombyx-mori
#4
Branislav Bednár, Ladislav Roller, Daniel Čižmár, Diana Mitrová, Dušan Žitňan
Allatotropin (AT) and related neuropeptides are widespread bioactive molecules that regulate development, food intake and muscle contractions in insects and other invertebrates. In moths, alternative splicing of the at gene generates three mRNA precursors encoding AT with different combinations of three structurally similar AT-like peptides (ATLI-III). We used in situ hybridization and immunohistochemistry to map the differential expression of these transcripts during the postembryonic development of Bombyx mori...
January 16, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28091629/mapping-the-sequence-structure-relationships-of-simple-cyclic-hexapeptides
#5
Sean M McHugh, Hongtao Yu, Diana P Slough, Yu-Shan Lin
Cyclic peptides are promising protein-protein interaction modulators with high binding affinities and specificities, as well as enhanced stabilities and oral availabilities over linear analogs. Despite their relatively small size and cyclic architecture, it is currently difficult to predict the favored conformation(s) of most classes of cyclic peptides. An improved understanding of the sequence-structure relationships for cyclic peptides will offer an avenue for the rational design of cyclic peptides as possible therapeutics...
January 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28091574/an-inert-pesticide-adjuvant-synergizes-viral-pathogenicity-and-mortality-in-honey-bee-larvae
#6
Julia D Fine, Diana L Cox-Foster, Christopher A Mullin
Honey bees are highly valued for their pollination services in agricultural settings, and recent declines in managed populations have caused concern. Colony losses following a major pollination event in the United States, almond pollination, have been characterized by brood mortality with specific symptoms, followed by eventual colony loss weeks later. In this study, we demonstrate that these symptoms can be produced by chronically exposing brood to both an organosilicone surfactant adjuvant (OSS) commonly used on many agricultural crops including wine grapes, tree nuts and tree fruits and exogenous viral pathogens by simulating a horizontal transmission event...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090567/the-rna-polymerase-iii-subunit-polr3b-is-required-for-the-maintenance-of-small-intestinal-crypts-in-mice
#7
Julia Kieckhaefer, Sabina Lukovac, Diana Z Ye, Dolim Lee, Danielle J Beetler, Michael Pack, Klaus H Kaestner
BACKGROUND & AIMS: The continuously self-renewing mammalian intestinal epithelium, with high cellular turnover, depends on adequate protein synthesis for its proliferative capacity. RNA polymerase III activity is closely related to cellular growth and proliferation. Here, we studied the role of Polr3b, a large RNA polymerase III subunit, in the mammalian intestinal epithelium. METHODS: We derived mice with an intestinal epithelium-specific hypomorphic mutation of the Polr3b gene, using VillinCre-mediated gene ablation...
November 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28089960/cohort-profile-the-environmental-influence-on-early-ageing-environage-a-birth-cohort-study
#8
Bram G Janssen, Narjes Madlhoum, Wilfried Gyselaers, Esmée Bijnens, Diana B Clemente, Bianca Cox, Janneke Hogervorst, Leen Luyten, Dries S Martens, Martien Peusens, Michelle Plusquin, Eline B Provost, Harry A Roels, Nelly D Saenen, Maria Tsamou, Annette Vriens, Ellen Winckelmans, Karen Vrijens, Tim S Nawrot
No abstract text is available yet for this article.
January 15, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28089953/transcatheter-treatment-of-severe-tricuspid-regurgitation-using-the-edge-to-edge-repair-technique
#9
Daniel Braun, Michael Nabauer, Mathias Orban, Martin Orban, Lisa Gross, Andrea Englmaier, Diana Rösler, Julinda Mehilli, Axel Bauer, Christian Hagl, Steffen Massberg, Jörg Hausleiter
AIMS: The aim of this study was to investigate the procedural feasibility and short-term durability of the transcatheter tricuspid valve edge-to-edge repair technique in highly symptomatic patients with severe tricuspid regurgitation (TR). METHODS AND RESULTS: Eighteen consecutive patients suffering from severe right-sided heart failure (NYHA Class III-IV), primarily due to moderate to severe tricuspid regurgitation, were included in the study. Applying a modified steering technique for the clip delivery system, six patients were treated for isolated severe TR, while 12 patients were treated for moderate to severe TR and concomitant severe mitral regurgitation...
January 17, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28089717/persistent-organic-pollutants-pops-in-human-follicular-fluid-and-in-vitro-fertilization-outcomes-a-pilot-study
#10
Michael S Bloom, Victor Y Fujimoto, Robin Storm, Li Zhang, Celeste D Butts, Diana Sollohub, Robert L Jansing
Persistent organic pollutants (POPs) are ubiquitously distributed among the U.S. population and adversely impact human reproduction. These compounds have been detected in human ovarian follicular fluid (FF), where they directly contact a developing oocyte. As a pilot investigation, we measured 43 polychlorinated biphenyl (PCB) congeners, p,p'-dichlorodiphenyltrichloroethane (DDT), and its persistent metabolite p,p'-dichlorodiphenyldichloroethylene (DDE) in residual FF collected from 32 women undergoing in vitro fertilization (IVF)...
January 9, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28089692/in-vitro-bioaccessibility-of-the-marine-biotoxins-okadaic-acid-dinophysistoxin-2-and-their-7-o-acyl-fatty-acid-ester-derivatives-in-raw-and-steamed-shellfish
#11
Diana Manita, Ricardo N Alves, Ana Catarina Braga, Fabiola Fogaça, António Marques, Pedro Reis Costa
Okadaic acid (OA), Dinophysistoxins (DTX1 and DTX2) and their acyl-derivatives (DTX3) are marine toxins responsible for the human diarrhetic shellfish poisoning. To date the amount of toxins ingested from consumption of shellfish has been considered equal to the amount of toxins available for uptake by the human body. The aim of this study is to assess the OA, DTX2 and DTX3 fractions released from raw and steamed mussels and cockles into the digestive fluids (bioaccessibility) using a static in vitro digestion model...
January 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28089668/ebio-does-not-induce-cardiomyogenesis-in-human-pluripotent-stem-cells-but-modulates-cardiac-subtype-enrichment-by-lineage-selective-survival
#12
Monica Jara-Avaca, Henning Kempf, Michael Rückert, Diana Robles-Diaz, Annika Franke, Jeanne de la Roche, Martin Fischer, Daniela Malan, Philipp Sasse, Wladimir Solodenko, Gerald Dräger, Andreas Kirschning, Ulrich Martin, Robert Zweigerdt
Subtype-specific human cardiomyocytes (CMs) are valuable for basic and applied research. Induction of cardiomyogenesis and enrichment of nodal-like CMs was described for mouse pluripotent stem cells (mPSCs) in response to 1-ethyl-2-benzimidazolinone (EBIO), a chemical modulator of small-/intermediate-conductance Ca(2+)-activated potassium channels (SKs 1-4). Investigating EBIO in human pluripotent stem cells (PSCs), we have applied three independent differentiation protocols of low to high cardiomyogenic efficiency...
January 4, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28088673/relationship-between-neonatal-gastroschisis-and-maternal-body-mass-index-in-a-united-kingdom-population
#13
Joann Hale, Abigail Derbyshire, Alexander Taylor, Clive Osmond, Diana Wellesley, David T Howe
OBJECTIVE: It has been reported that gastroschisis is associated with low maternal body mass index (BMI). We tested this hypothesis in the UK. STUDY DESIGN: We studied cases of gastroschisis ascertained from the regional fetal congenital anomaly register. We compared each affected mother with two controls from the birth register and maternity database. The first control was the next mother to deliver in the hospital, representing the normal population of mothers...
December 15, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28088377/intracapsular-hip-fractures-in-the-elderly-do-we-know-what-is-important
#14
Diana Crego-Vita, Coral Sanchez-Perez, Jose Adolfo Orellana Gomez-Rico, Celia Clemente de Arriba
BACKGROUND: Hip fractures in the elderly are a common reason for admission to the department of orthopaedic surgery, this condition asks an important part of health resources and is associated with high levels of co-morbidity and mortality. Many improvements have been introduced in the treatment of these patients, preoperative regional analgesia, intensive physical therapy, interdisciplinary care program; but still remain unresolved gaps. The aim of this study is to document the natural history of early versus delayed surgical intervention in elderly patients with hip fractures and to establish the prognostic factors of mortality and walking ability after discharge...
January 9, 2017: Injury
https://www.readbyqxmd.com/read/28087957/cardiovascular-risk-assessment-between-urban-and-rural-population-in-malaysia
#15
I Noor Hassim, M R Norazman, M Diana, Y Khairul Hazdi, I Rosnah
INTRODUCTION: Cardiovascular disease (CVD) caused significant burden to Malaysia as it accounted for 36% of total deaths. This study aims to evaluate the burden of cardiovascular risk factors among Malaysian adult and assess the difference between urban and rural population in the selected communities. METHODS: This study is part of the ongoing Prospective Urban Rural Epidemiology (PURE) database, whereby the baseline data were collected since June 2008. CVD risk was measured using INTERHEART risk score which comprised of eleven risk factors i...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28087830/recognition-of-the-magnaporthe-oryzae-effector-avr-pia-by-the-decoy-domain-of-the-rice-nlr-immune-receptor-rga5
#16
Diana Ortiz, Karine De Guillen, Stella Cesari, Véronique Chalvon, Jérome Gracy, André Padilla, Thomas Kroj
Nucleotide-binding domain and leucine-rich repeat proteins (NLRs) are important receptors in plant immunity that allow recognition of pathogen effectors. The rice NLR RGA5 recognizes the Magnaporthe oryzae effector AVR-Pia through direct interaction. Here, we gained detailed insights into the molecular and structural bases of AVR-Pia-RGA5 interaction and the role of the RATX1 decoy domain of RGA5. NMR titration combined with in vitro and in vivo protein-protein interaction analyses identified the AVR-Pia interaction surface that binds to the RATX1 domain...
January 13, 2017: Plant Cell
https://www.readbyqxmd.com/read/28087626/snail2-and-zeb2-repress-p-cadherin-to-define-embryonic-territories-in-the-chick-embryo
#17
Hervé Acloque, Oscar H Ocaña, Diana Abad, Claudio D Stern, M Angela Nieto
Snail and Zeb transcription factors induce epithelial to mesenchymal transition (EMT) in embryonic and adult tissues by direct repression of E-Cadherin transcription. The repression of E-Cadherin transcription by the EMT inducers Snail1 and Zeb2 plays a fundamental role in defining embryonic territories in the mouse, as E-Cadherin needs to be downregulated in the primitive streak and in the epiblast concomitant with the formation of mesendodermal precursors and the neural plate, respectively. Here we show that in the chick embryo, E-Cadherin is weakly expressed in the epiblast at pre-primitive streak stages where it is substituted by P-Cadherin We also show that Snail2 and Zeb2 repress P-Cadherin transcription in the primitive streak and the neural plate, respectively...
January 13, 2017: Development
https://www.readbyqxmd.com/read/28087490/longitudinal-multiple-sclerosis-lesion-segmentation-resource-challenge
#18
Aaron Carass, Snehashis Roy, Amod Jog, Jennifer L Cuzzocreo, Elizabeth Magrath, Adrian Gherman, Julia Button, James Nguyen, Ferran Prados, Carole H Sudre, Manuel Jorge Cardoso, Niamh Cawley, Olga Ciccarelli, Claudia A M Wheeler-Kingshott, Sébastien Ourselin, Laurence Catanese, Hrishikesh Deshpande, Pierre Maurel, Olivier Commowick, Christian Barillot, Xavier Tomas-Fernandez, Simon K Warfield, Suthirth Vaidya, Abhijith Chunduru, Ramanathan Muthuganapathy, Ganapathy Krishnamurthi, Andrew Jesson, Tal Arbel, Oskar Maier, Heinz Handels, Leonardo O Iheme, Devrim Unay, Saurabh Jain, Diana M Sima, Dirk Smeets, Mohsen Ghafoorian, Bram Platel, Ariel Birenbaum, Hayit Greenspan, Pierre-Louis Bazin, Peter A Calabresi, Ciprian M Crainiceanu, Lotta M Ellingsen, Daniel S Reich, Jerry L Prince, Dzung L Pham
In conjunction with the ISBI 2015 conference, we organized a longitudinal lesion segmentation challenge providing training and test data to registered participants. The training data consisted of five subjects with a mean of 4.4 time-points, and test data of fourteen subjects with a mean of 4.4 time-points. All 82 data sets had the white matter lesions associated with multiple sclerosis delineated by two human expert raters. Eleven teams submitted results using state-of-the-art lesion segmentation algorithms to the challenge, with ten teams presenting their results at the conference...
January 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28087270/examining-the-reliability-and-validity-of-the-clinical-assessment-interview-for-negative-symptoms-within-the-management-of-schizophrenia-in-clinical-practice-mosaic-multisite-national-study
#19
Jack J Blanchard, Kristen R Bradshaw, Cristina P Garcia, Henry A Nasrallah, Philip D Harvey, Daniel Casey, Csilla T Csoboth, James I Hudson, Laura Julian, Ellen Lentz, Keith H Nuechterlein, Diana O Perkins, Tracey G Skale, Lonnie R Snowden, Rajiv Tandon, Cenk Tek, Dawn Velligan, Sophia Vinogradov, Cedric O'Gorman
The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CAINS were examined within the Management of Schizophrenia in Clinical Practice (MOSAIC) schizophrenia registry. A total of 501 participants with a schizophrenia spectrum diagnosis who were receiving usual care were recruited across 15 national Patient Assessment Centers and evaluated with the CAINS, other negative symptom measures, and assessments of functioning, quality of life and cognition...
January 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28086942/external-beam-radiotherapy-for-unresectable-hepatocellular-carcinoma-an-international-multicenter-phase-i-trial-sakk-77-07-and-sasl-26
#20
Evelyn Herrmann, Diana Naehrig, Manfred Sassowsky, Martin Bigler, Jeroen Buijsen, Ilja Ciernik, Daniel Zwahlen, Alessandra Franzetti Pellanda, Andreas Meister, Peter Brauchli, Simona Berardi, Erika Kuettel, Jean-François Dufour, Daniel M Aebersold
PURPOSE: To assess feasibility and safety of conventionally fractionated radiotherapy (cfRT) in patients with hepatocellular carcinoma (HCC). METHODS: Patients with histologically confirmed stage cT1-4, cN0-1 HCC and Child-Pugh Score (CPS) A or B disease were included in a phase I multicenter trial. Metastatic HCC were allowed if ≥90% of total tumor volume was located within the liver. Patients were enrolled onto five dose-escalation levels (54-70Gy in 2Gy fractions) based on a modified 3 + 3 design, with cohorts of five patients instead of three patients in dose levels 4 and 5...
January 13, 2017: Radiation Oncology
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