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https://www.readbyqxmd.com/read/29352696/safety-and-efficacy-of-prostatic-artery-chemoembolization-for-prostate-cancer-initial-experience
#1
João Pisco, Tiago Bilhim, Nuno V Costa, Manuel Pinto Ribeiro, Lucia Fernandes, António G Oliveira
PURPOSE: To evaluate outcome of prostatic artery chemoembolization for patients with prostate cancer (PCa). MATERIALS AND METHODS: This single-center prospective cohort study was conducted between August 2013 and July 2016 in 20 patients with PCa who underwent chemoembolization. Mean patient age was 67.5 years ± 6.4. Gleason score was 6-10, and staging was T2N0M0. Fifteen patients refused prostatectomy and 5 wanted to stop hormonal therapy because of side effects...
January 15, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29350310/proanthocyanidins-and-the-risk-of-prostate-cancer-in-italy
#2
Delphine Praud, Maria Parpinel, Valentina Guercio, Cristina Bosetti, Diego Serraino, Gaetano Facchini, Maurizio Montella, Carlo La Vecchia, Marta Rossi
Proanthocyanidins are polymers of monomeric unit flavan-3-ols with antioxidant, anti-inflammatory and free radical scavenging activities. We investigated the association between proanthocyanidin intake and prostate cancer risk through data that were collected between 1991 and 2002 in an Italian case-control study, including a total of 1,294 incident, histologically confirmed cases of prostate cancer and 1,451 controls admitted to hospital for acute, non-neoplastic, and non-hormone-related diseases. We estimated odds ratios (ORs) and their 95% confidence intervals (CIs) using multiple logistic regression models, and computed energy-adjusted proanthocyanidin intakes using the residual method...
January 19, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29349945/the-within-group-discrimination-ability-of-the-cancer-of-the-prostate-risk-assessment-score-for-men-with-intermediate-risk-prostate-cancer
#3
Ho Won Kang, Hae Do Jung, Joo Yong Lee, Jong Kyou Kwon, Seong Uk Jeh, Kang Su Cho, Won Sik Ham, Young Deuk Choi
BACKGROUND: Significant clinical heterogeneity within contemporary risk group is well known, particularly for those with intermediate-risk prostate cancer (IRPCa). Our study aimed to analyze the ability of the Cancer of the Prostate Risk Assessment (CAPRA) score to discern between favorable and non-favorable risk in patients with IRPCa. METHODS: We retrospectively reviewed the data of 203 IRPCa patients who underwent extraperitoneal robot-assisted radical prostatectomy (RARP) performed by a single surgeon...
January 29, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29349937/changes-in-clinical-characteristics-of-patients-with-an-initial-diagnosis-of-prostate-cancer-in-korea-10-year-trends-reported-by-a-tertiary-center
#4
Ji Eun Heo, Hyun Kyu Ahn, Jinu Kim, Byung Ha Chung, Kwang Suk Lee
BACKGROUND: The Korea Central Cancer Registry reported that incidence rates of prostate cancer have not increased continuously. We used recent trends in the incidence of prostate cancer to generate a preliminary report of the Korean population with prostate cancer. METHODS: Patients initially diagnosed with prostate cancer by prostate biopsy from 2006 to 2015 at our tertiary center were selected. All patients were categorized according to age (< 65, 65-75, > 75 years), time period (2006-2010 vs...
February 5, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29345442/lung-uptake-of-fluorine-18-fluoroethyl-choline-pet-ct-in-patients-with-prostate-cancer
#5
Daniele A Pizzuto, Salvatore Annunziata, Francesco P Ieria, Carmelo Caldarella, Maria A Isgrò, Valerio Lanni, Gaia Bencivenga, Vittoria Rufini, Alessandro Giordano
BACKGROUND: Metastatic spreading to the lungs is a negative prognostic factor in patients with prostate cancer (PC). Aim of our study was to assess the prevalence of lung PC metastases in patients with fluorine-18 fluoroethyl-choline (F-18-FECh) PET-CT positive lung lesions and the role of Gleason Score (GS) and common biochemical markers in predicting metastatic spreading to the lungs. METHODS: We retrospectively evaluated the scans of 1283 patients ongoing (F-18-FECh) PET-CT for PC between May 2010 and July 2014...
January 17, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29345000/cell-death-under-epithelial-mesenchymal-transition-control-in-prostate-cancer-therapeutic-response
#6
REVIEW
Diane Begemann, Harry Anastos, Natasha Kyprianou
Prostate cancer is a widespread problem among men, with >160 000 new cases in 2017 alone. Androgen deprivation therapy is commonly used in prostate cancer treatment to block androgens required for cancer growth, but disease relapse after androgen deprivation therapy is both common and severe. Changes in androgen receptor signaling from androgen deprivation therapy have been linked to therapeutic resistance and tumor progression. Resistant cells can become reprogrammed to undergo epithelial-mesenchymal transition, a phenotypic switch from benign, epithelial cells to a mobile cell with mesenchymal traits...
January 17, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29344118/shisa2-enhances-the-aggressive-phenotype-in-prostate-cancer-through-the-regulation-of-wnt5a-expression
#7
Kenji Tamura, Mutsuo Furihata, Hirofumi Satake, Hatsune Hashida, Chiaki Kawada, Hiroto Osakabe, Hideo Fukuhara, Naoko Kumagai, Tatsuo Iiyama, Taro Shuin, Keiji Inoue
The present study aimed at identifying novel molecular cancer drug targets and biomarkers by analyzing the gene expression profiles of high-grade prostate cancer (PC), using a cDNA microarray combined with laser microbeam microdissection. A number of genes were identified that were transactivated in high-grade PC. First, a novel molecular target and diagnostic biomarker, shisa family member 2 (SHISA2), was identified as an overexpressed gene in high-grade PC cells. The reverse transcription-semi-quantitative polymerase chain reaction and immunohistochemical analysis validated the overexpression of SHISA2 (295 amino acids in length), specifically in high-grade PC cells with Gleason scores of between 8 and 10, relative to normal prostate epithelium...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29340839/the-cumulative-incidence-and-risk-factors-of-postoperative-inguinal-hernia-in-patients-undergoing-radical-prostatectomy
#8
Ja Yoon Ku, Chan Ho Lee, Won Young Park, Nam Kyung Lee, Seung Hyun Baek, Hong Koo Ha
BACKGROUND: The aim of this study is to investigate the cumulative incidence and risk factors of postoperative inguinal hernia (PIH) in patients undergoing radical prostatectomy, i.e., laparoscopic prostatectomy (LRP) and robot-assisted laparoscopic prostatectomy (RARP). METHODS: This study included 1124 patients who had undergone radical prostatectomy or transurethral resection of bladder tumor from 2011-2016. We compared the cumulative incidence of PIH in the radical prostatectomy groups (460; LRP 341, RARP 119) and the control group (664; transurethral resection of bladder tumor), and we then analyzed the risk factors (age, operative methods, previous abdominal operative history, thickness and width of external oblique muscle and rectus muscle, thickness of abdominal subcutaneous fat layer at Hesselbach's triangle level, body mass index, prostate-specific antigen, operative time, specimen weight, Gleason score, and pathology T-stage) of PIH in the radical prostatectomy groups...
January 16, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29340038/diagnostic-performance-of-68gallium-psma-11-pet-ct-to-detect-significant-prostate-cancer-and-comparison-with-18fec-pet-ct
#9
Manuela A Hoffmann, Matthias Miederer, Helmut J Wieler, Christian Ruf, Frank M Jakobs, Mathias Schreckenberger
Background: Radiolabeled prostate-specific membrane antigen (PSMA) has proven to be a highly accurate method to detect recurrence and metastases of prostate cancer, but only sparse data is available about its performance in the diagnosis of clinically significant primary prostate cancer. Methods: We compared 68Ga-PSMA-11 PET/CT in 25 patients with 18FEC PET/CT in 40 patients with suspected prostate carcinoma based on an increased PSA level.The PET/CT results were compared with the histopathologic Gleason Score (GS) of biopsies...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339806/tumor-characteristics-treatments-and-oncological-outcomes-of-prostate-cancer-in-men-aged-%C3%A2-50-years-a-population-based-study
#10
Raisa S Pompe, Ariane Smith, Marco Bandini, Michele Marchioni, Tristan Martel, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Fred Saad, Hartwig Huland, Markus Graefen, Shahrokh F Shariat, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: To examine clinical characteristics, treatment modalities and oncological outcomes of prostate cancer (PCa) according to young (≤50) vs. old age. METHODS: Of 407,599 men with primary adenocarcinoma of the prostate within the Surveillance, Epidemiology and End Results (SEER)-database (2004 to 2013), 18,387 were aged ≤50 years (4.5%). Time trends, cumulative incidence, and competing risks regression (CRR) analyses tested for differences between young and old patients...
January 16, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29339663/evaluation-of-magnetic-resonance-imaging-ultrasound-fusion-biopsy-in-patients-with-low-risk-prostate-cancer-under-active-surveillance-undergoing-surveillance-biopsy
#11
Angelika Borkowetz, Theresa Renner, Ivan Platzek, Marieta Toma, Roman Herout, Martin Baunacke, Christer Groeben, Johannes Huber, Michael Laniado, Gustavo B Baretton, Michael Froehner, Stefan Zastrow, Manfred P Wirth
INTRODUCTION: Targeted biopsy of tumour-suspicious lesions detected in multiparametric magnetic resonance imaging (mpMRI) plays an increasing role in the active surveillance (AS) of patients with low-risk prostate cancer (PCa). The aim of this study was to compare MRI/ultrasound-fusion biopsy (fusPbx) with systematic biopsy (sysPbx) in patients undergoing biopsy for AS. METHODS: Patients undergoing mpMRI and transperineal fusPbx combined with transrectal sysPbx (comPbx) as surveillance biopsy were investigated...
January 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29338305/safety-and-feasibility-of-prostate-stereotactic-ablative-radiotherapy-using-multi-modality-imaging-and-flattening-filter-free
#12
Aileen Duffton, Azmat Sadozye, Lynsey Devlin, Nicholas MacLeod, Carolynn Lamb, Suzanne Smith, Philip McLoone, Muthu Sankaralingam, John Foster, Stephanie Paterson, Stefanie Keatings, David Dodds
PURPOSE: To investigate feasibility and safety of SABR in the management of prostate cancer while employing MR/CT fusion for delineation, fiducial markers seeds for positioning and Varian Rapidarc with FFF delivery. METHODS: Forty-one patients were treated for low-intermediate risk prostate cancer with initial PSA (iPSA) of ≤20ng/ml, Gleason score 6-7. Patients had MR/CT fusion for delineation of prostate +/-seminal vesicles. CT/MR fusion images were used for delineation and planned using flattening filter free modality...
January 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29333577/prostate-cancer-patients-understanding-of-the-gleason-scoring-system-implications-for-shared-decision-making
#13
Erin K Tagai, Suzanne M Miller, Alexander Kutikov, Michael A Diefenbach, Ronak A Gor, Tahseen Al-Saleem, David Y T Chen, Sara Fleszar, Gem Roy
The Gleason scoring system is a key component of a prostate cancer diagnosis, since it indicates disease aggressiveness. It also serves as a risk communication tool that facilitates shared treatment decision-making. However, the system is highly complex and therefore difficult to communicate: factors which have been shown to undermine well-informed and high-quality shared treatment decision-making. To systematically explore prostate cancer patients' understanding of the Gleason scoring system (GSS), we assessed knowledge and perceived importance among men who had completed treatment (N = 50)...
January 15, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29332451/psca-rs1045531-polymorphism-and-the-risk-of-prostate-cancer-in-a-chinese-population-undergoing-prostate-biopsy
#14
Xuefeng Zhang, Qin Hu, Ye Chen, Miao Li, Huming Yin, Chenchao Zhou, Gang Li, Jianquan Hou
BACKGROUND AND PURPOSE: This study explored the association between a single-nucleotide polymorphism of prostate stem cell antigen and prostate cancer in Chinese patients undergoing prostate biopsy. MATERIALS AND METHODS: DNA from 416 patients undergoing prostate biopsy was typed for the prostate stem cell antigen rs1045531 single-nucleotide polymorphism. The frequency of the rs1045531 polymorphism in patients with prostate cancer and in patients with benign prostatic hyperplasia was compared...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29332354/inhibition-of-telomerase-potentiates-enzalutamide-efficiency-of-androgen-sensitive-human-prostate-cancer-cells
#15
Karaca Kaan Gecgel, Mustafa Muduroglu, Suat Erdogan
PURPOSE: Androgen deprivation therapy (ADT) is one of the main strategies to treat prostate cancer (PCa) at various stages of its development. Androgen receptor (AR) antagonists such as enzalutamide are mainstay treatments for castration-sensitive prostate cancer. Though, a majority of patients initially respond to ADT, most will eventually progress to castrate-resistant, due to the development of different mutations on the AR. PCa cells express high telomerase activity, and there is a correlation between the total activity of telomerase and the Gleason score...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331622/value-of-serial-multiparametric-magnetic-resonance-imaging-and-magnetic-resonance-imaging-guided-biopsies-in-men-with-low-risk-prostate-cancer-on-active-surveillance-after-1-yr-follow-up
#16
Esther Hendrika Johanna Hamoen, Caroline M A Hoeks, Diederik M Somford, Inge M van Oort, Henk Vergunst, Jorg R Oddens, Geert A Smits, Leonard P Bokhorst, J Alfred Witjes, Maroeska M Rovers, Christina A Hulsbergen-van de Kaa, Jelle O Barentsz
BACKGROUND: Active surveillance (AS) aims to reduce overtreatment of low-risk prostate cancer (PC). Incorporating multiparametric magnetic resonance imaging (mp-MRI) and MR-guided biopsy (MRGB) in an AS protocol might contribute to more accurate identification of AS candidates. OBJECTIVE: To evaluate the value of 3T mp-MRI and MRGB in PC patients on AS at inclusion and after 12-mo follow-up. DESIGN, SETTING, AND PARTICIPANTS: Patients with cT1c-cT2 PC, prostate-specific antigen (PSA) ≤10ng/ml, PSA density <0...
January 10, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29331421/hyperglycaemia-induced-mir-301a-promotes-cell-proliferation-by-repressing-p21-and-smad4-in-prostate-cancer
#17
Xiaojuan Li, Jun Li, Yi Cai, Shubin Peng, Jun Wang, Zhaoming Xiao, Yu Wang, Yiran Tao, Jun Li, Qu Leng, Dinglan Wu, Shaodong Yang, Ziliang Ji, Yuefu Han, Liren Li, Xin Gao, Chunxian Zeng, Xingqiao Wen
Hyperglycaemia promotes the development of Prostate cancer (PCa). However, the roles of miRNAs in this disease process and the underlying mechanisms are largely unknown. In this study, we recruited 391 PCa patients in China and found that PCa patients with high level blood glucose (≥100 mg/dL) trended to have high Gleason score (GS≥7). miRNA-301a levels were significantly higher in prostate cancer than that in normal prostate tissues. Hyperglycaemia or high glucose treatment induced miR-301a expression in prostate tissues or PCa cell lines...
January 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29331214/the-stockholm-3-model-for-prostate-cancer-detection-algorithm-update-biomarker-contribution-and-reflex-test-potential
#18
Peter Ström, Tobias Nordström, Henrik Grönberg, Martin Eklund
BACKGROUND: It has been shown that the Stockholm-3 model (S3M) outperforms prostate-specific antigen (PSA) as a screening tool for prostate cancer. OBJECTIVE: To update the S3M, to give a detailed account of the value of each predictor in the S3M, and to evaluate the S3M as a reflex test for men with PSA ≥3ng/ml. DESIGN, SETTING, AND PARTICIPANTS: During 2012-2015, the Stockholm-3 study evaluated the S3M relative to PSA as tests for Gleason score ≥7 prostate cancers among men aged 50-69 yr...
January 10, 2018: European Urology
https://www.readbyqxmd.com/read/29330001/in-bore-3-0-t-magnetic-resonance-imaging-guided-transrectal-targeted-prostate-biopsy-in-a-repeat-biopsy-population-diagnostic-performance-complications-and-learning-curve
#19
Alexander Friedl, Jenifer Schneeweiss, Sabina Sevcenco, Klaus Eredics, Thomas Kunit, Martin Susani, Danijel Kivaranovic, Edith Eisenhuber-Stadler, Lukas Lusuardi, Clemens Brössner, Wolfgang Schima
OBJECTIVE: To evaluate the diagnostic performance and complication rate of the in-bore magnetic resonance imaging-guided transrectal targeted prostate biopsy (MRGB) in a repeat biopsy population on basis of a nearly four year learning curve (2014-2017). MATERIALS AND METHODS: A total of 142 consecutive males with a history of previous biopsies and persistent suspicion of prostate cancer (PCa) due to prostate specific antigen (PSA) elevation initially underwent MRGB in the case of prostate imaging reporting and data system (PI-RADS) 3-5 lesions...
January 9, 2018: Urology
https://www.readbyqxmd.com/read/29327138/handling-and-reporting-of-transperineal-template-prostate-biopsy-in-europe-a-web-based-survey-by-the-european-network-of-uropathology-enup
#20
Solene-Florence Kammerer-Jacquet, Eva Compérat, Lars Egevad, Ondra Hes, Jon Oxley, Murali Varma, Glen Kristiansen, Daniel M Berney
Transperineal template prostate biopsies (TTPB) are performed for assessments after unexpected negative transrectal ultrasound biopsies (TRUSB), correlation with imaging findings and during active surveillance. The impact of TTPBs on pathology has not been analysed. The European Network of Uropathology (ENUP) distributed a survey on TTPB, including how specimens were received, processed and analysed. Two hundred forty-four replies were received from 22 countries with TTPBs seen by 68.4% of the responders (n = 167)...
January 11, 2018: Virchows Archiv: An International Journal of Pathology
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