Khadijeh Chakamian, Behrouz Robat-Jazi, Abdorreza Naser Moghadasi, Fatemeh Mansouri, Masoumeh Nodehi, Elahe Motevaseli, Maryam Izad, Saeed Yekaninejad, Mahdieh Shirzad, Kiana Bidad, Mona Oraei, Bita Ansaripour, Ali Akbar Saboor-Yaraghi
T cells play an important role in the development and progression of multiple sclerosis (MS), an autoimmune disease of the central nervous system. In the present study, the immunomodulatory impacts of two Lactobacillus strains, L paracasei DSM 13434 and L plantarum DSM 15312, on the frequency and cytokine production of CD4+ T cells in MS patients were explored. Thirty MS patients were enrolled in this study. The CD4+ T cells were isolated, cultured, and exposed to the media containing cell-free supernatants of L plantarum (group1), L paracasei (group 2), the mixture group of cell-free supernatants of both probiotics (group 3), and vehicle (control) group (group 4)...
February 20, 2023: Iranian Journal of Allergy, Asthma, and Immunology