Andreina Marques-Mejias, Irene Bartha, Christina E Ciaccio, R Sharon Chinthrajah, Susan Chan, Gurjit K Khurana Hershey, Jessica W Hui-Beckman, Laurie Kost, Gideon Lack, Janice A Layhadi, Donald Y M Leung, Hannah F Marshall, Kari C Nadeau, Suzana Radulovic, Reena Rajcoomar, Mohamed H Shamji, Sayantani Sindher, Helen A Brough
The fact that genetic and environmental factors could trigger disruption of the epithelial barrier and subsequently initiate a Th2 inflammatory cascade conversely proposes that protecting the same barrier and promoting adequate interactions with other organs, like the gut, may be crucial for lowering the risk and preventing atopic diseases particularly, food allergies. In this review, we provide an overview of structural characteristics that support the epithelial barrier hypothesis in AD patients, including the most relevant filaggrin gene mutations, the recent discovery of the role of the transient receptor potential vanilloid 1 (TRPV1), and the role involvement of the microbiome in healthy and damaged skin...
January 20, 2024: Annals of Allergy, Asthma & Immunology