Eun Bin Cho, Ju-Hong Min, Patrick Waters, Miyoung Jeon, Eun-Seon Ju, Ho Jin Kim, Su-Hyun Kim, Ha Young Shin, Sa-Yoon Kang, Young-Min Lim, Sun-Young Oh, Hye Lim Lee, Eunhee Sohn, Sang-Soo Lee, Jeeyoung Oh, Sunyoung Kim, So-Young Huh, Joong-Yang Cho, Jin Myoung Seok, Byung-Jo Kim, Byoung Joon Kim
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody (MOG) immunoglobulin G (IgG)-associated disease (MOGAD) has clinical and pathophysiological features that are similar to but distinct from those of aquaporin-4 antibody (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (AQP4-NMOSD). MOG-IgG and AQP4-IgG, mostly of the IgG1 subtype, can both activate the complement system. Therefore, we investigated whether the levels of serum complement components, regulators, and activation products differ between MOGAD and AQP4-NMOSD, and if complement analytes can be utilized to differentiate between these diseases...
2024: Frontiers in Immunology