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C3 complement

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https://www.readbyqxmd.com/read/29759419/circulating-complement-factor-h-related-protein-5-levels-contribute-to-development-and-progression-of-iga-nephropathy
#1
Li Zhu, Wei-Yi Guo, Su-Fang Shi, Li-Jun Liu, Ji-Cheng Lv, Nicholas R Medjeral-Thomas, Hannah J Lomax-Browne, Matthew C Pickering, Hong Zhang
IgA nephropathy (IgAN) is a disease associated with activation of the complement system. But the factors influencing complement activation in IgAN are not fully understood. Complement factor H (FH) is an essential negative regulator of complement C3 activation. Complement factor H-related protein (FHR)-5 shares high sequence similarity with factor H. However, unlike factor H, on binding to activated C3 it enables further activation to proceed. Previously, we reported the contribution of rare variants of the CFHR5 gene to IgAN susceptibility...
May 11, 2018: Kidney International
https://www.readbyqxmd.com/read/29759078/transcriptome-analysis-of-alcohol-treated-microglia-reveals-downregulation-of-beta-amyloid-phagocytosis
#2
Sergey Kalinin, Marta González-Prieto, Hannah Scheiblich, Lucia Lisi, Handojo Kusumo, Michael T Heneka, Jose L M Madrigal, Subhash C Pandey, Douglas L Feinstein
BACKGROUND: Microglial activation contributes to the neuropathology associated with chronic alcohol exposure and withdrawal, including the expression of inflammatory and anti-inflammatory genes. In the current study, we examined the transcriptome of primary rat microglial cells following incubation with alcohol alone, or alcohol together with a robust inflammatory stimulus. METHODS: Primary microglia were prepared from mixed rat glial cultures. Cells were incubated with 75 mM ethanol alone or with proinflammatory cytokines ("TII": IL1β, IFNγ, and TNFα)...
May 14, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29754764/monitoring-of-early-humoral-immunity-to-identify-lung-recipients-at-risk-for-development-of-serious-infections-a-multicenter-prospective-study
#3
Elizabeth Sarmiento, Jose Cifrian, Leticia Calahorra, Carles Bravo, Sonia Lopez, Rosalia Laporta, Piedad Ussetti, Amparo Sole, Carmen Morales, Alicia de Pablos, Maria Jaramillo, Ikram Ezzahouri, Sandra García, Joaquin Navarro, Marcos Lopez-Hoyos, Javier Carbone
BACKGROUND: Infection is still a leading cause of death during the first year after lung transplantation. We performed a multicenter study among teaching hospitals to assess monitoring of early humoral immunity as a means of identifying lung recipients at risk of serious infections. METHODS: We prospectively analyzed 82 adult lung recipients at 5 centers in Spain. Data were collected before transplantation and at 7 and 30 days after transplantation. Biomarkers included IgG, IgM, IgA, complement factors C3 and C4, titers of antibodies to pneumococcal polysaccharide antigens (IgG, IgA, IgM) and antibodies to cytomegalovirus (IgG), and serum B-cell activating factor (BAFF) levels...
April 6, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29752310/extracellular-histones-inhibit-complement-activation-through-interacting-with-complement-component-4
#4
Yasir Qaddoori, Simon T Abrams, Paul Mould, Yasir Alhamdi, Stephen E Christmas, Guozheng Wang, Cheng-Hock Toh
Complement activation leads to membrane attack complex formation, which can lyse not only pathogens but also host cells. Histones can be released from the lysed or damaged cells and serve as a major type of damage-associated molecular pattern, but their effects on the complement system are not clear. In this study, we pulled down two major proteins from human serum using histone-conjugated beads: one was C-reactive protein and the other was C4, as identified by mass spectrometry. In surface plasmon resonance analysis, histone H3 and H4 showed stronger binding to C4 than other histones, with KD around 1 nM...
May 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29750504/c1q-mediated-complement-activation-and-c3-opsonization-trigger-recognition-of-stealth-poly-2-methyl-2-oxazoline-coated-silica-nanoparticles-by-human-phagocytes
#5
Regina Tavano, Luca Gabrielli, Elisa Lubian, Chiara Fedeli, Silvia Visentin, Patrizia Polverino de Laureto, Giorgio Arrigoni, Alessandra Geffner-Smith, Fangfang Chen, Dmitri Simberg, Giulia Morgese, Edmondo Maria Benetti, Linping Wu, Seyed Moein Moghimi, Fabrizio Mancin, Emanuele Papini
Poly(2-methyl-2-oxazoline) (PMOXA) is an alternative promising polymer to poly(ethylene glycol), (PEG), for design and engineering of macrophage-evading nanoparticles (NPs). Although PMOXA engineered NPs have shown comparable pharmacokinetics, and in vivo performance to PEGylated stealth NPs in the murine model, its interaction with elements of the human innate immune system has not been studied. From a translational angle, we studied the interaction of fully characterized PMOXA-coated vinyl-triethoxysilane-derived organically modified silica NPs (PMOXA-coated NPs) of approximately 100 nm in diameter with human complement system, blood leukocytes and macrophages, and compared their performance with PEGylated and uncoated NP counterparts...
May 11, 2018: ACS Nano
https://www.readbyqxmd.com/read/29746835/complement-c3-drives-autophagy-dependent-restriction-of-cyto-invasive-bacteria
#6
Matthew T Sorbara, Elisabeth G Foerster, Jessica Tsalikis, Mena Abdel-Nour, Joseph Mangiapane, Imogen Sirluck-Schroeder, Ivan Tattoli, Rob van Dalen, David E Isenman, John R Rohde, Stephen E Girardin, Dana J Philpott
In physiological settings, the complement protein C3 is deposited on all bacteria, including invasive pathogens. However, because experimental host-bacteria systems typically use decomplemented serum to avoid the lytic action of complement, the impact of C3 coating on epithelial cell responses to invasive bacteria remains unexplored. Here, we demonstrate that following invasion, intracellular C3-positive Listeria monocytogenes is targeted by autophagy through a direct C3/ATG16L1 interaction, resulting in autophagy-dependent bacterial growth restriction...
May 9, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29743491/classical-and-alternative-complement-activation-on-photoreceptor-outer-segments-drives-monocyte-dependent-retinal-atrophy
#7
Kenneth J Katschke, Hongkang Xi, Christian Cox, Tom Truong, Yann Malato, Wyne P Lee, Brent McKenzie, Rommel Arceo, Jianhua Tao, Linda Rangell, Mike Reichelt, Lauri Diehl, Justin Elstrott, Robby M Weimer, Menno van Lookeren Campagne
Geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD), is characterized by progressive loss of retinal pigment epithelium cells and photoreceptors in the setting of characteristic extracellular deposits and remains a serious unmet medical need. While genetic predisposition to AMD is dominated by polymorphisms in complement genes, it remains unclear how complement activation contributes to retinal atrophy. Here we demonstrate that complement is activated on photoreceptor outer segments (POS) in the retina peripheral to atrophic lesions associated with GA...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29742812/binding-of-free-and-immune-complex-associated-hepatitis-c-virus-to-erythrocytes-is-mediated-by-the-complement-system
#8
Kazi Abdus Salam, Richard Y Wang, Teresa Grandinetti, Valeria De Giorgi, Harvey J Alter, Robert D Allison
Erythrocytes bind circulating immune complexes (IC) and facilitate IC clearance from the circulation. Chronic hepatitis C virus (HCV) infection is associated with IC-related disorders. In this study we investigated the kinetics and mechanism of HCV and HCV-IC binding to and dissociation from erythrocytes. Cell culture-produced HCV was mixed with erythrocytes from healthy blood donors and erythrocyte-associated virus particles were quantified. Purified complement proteins, complement-depleted serum, and complement receptor antibodies were used to investigate complement-mediated HCV-erythrocyte binding...
May 9, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29742493/association-between-polymorphisms-of-the-complement-3-gene-and-schizophrenia-in-a-han-chinese-population
#9
Shangchao Zhang, Na Zhou, Rui Liu, Wenwang Rao, Mingjia Yang, Bonan Cao, Guojun Kang, Qi Kang, Xiaojing Zhu, Rixin Li, Yaqin Yu, Qiong Yu
BACKGROUND/AIMS: Schizophrenia is a severe psychiatric disorder, and complement 3 (C3) is closely related to schizophrenia. We investigated the association between C3 polymorphisms and schizophrenia in a Northeast Han Chinese population. METHODS: A total of 2240 Chinese people, consisting of 1086 patients with schizophrenia and 1154 healthy controls, were recruited for this study. Ten single nucleotide polymorphisms (SNPs; rs11569562, rs344555, rs2241393, rs2241392, rs11569514, rs445750, rs451760, rs11672613, rs2230205, and rs2250656) in C3 were selected and genotyped...
May 5, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29739081/subclasses-of-monoclonal-type-i-immunoglobulin-g-cryoglobulins-report-on-two-distinct-cases-with-myeloma
#10
Tania Petersen, Sebastien Riviere, Stephanie Malbos, Yannick Chantran, Aicha Abbas, Francois Chasset, Arsene Mekinian, Jeremie Sellam, Laurent Garderet, Pierre Aucouturier
BACKGROUND: While different clinical manifestations of IgM and IgG monoclonal cryoglobulins have been demonstrated, little is known about the roles of IgG subclasses in the pathophysiology of these conditions. METHODS: In two cases of myeloma-associated monoclonal (type I) cryoglobulinemia with quite distinct clinical and biological features, serum samples were analyzed using an original IgG subclass-specific immunoblotting technique. RESULTS: The first case had painful arthritis of hands and feet, with skin purpura and a sharp decrease of complement C4 level, and the cryoglobulin was of IgG1 subclass...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738834/interaction-of-complement-system-and-microglia-activation-in-retina-and-optic-nerve-in-a-nmda-damage-model
#11
Sandra Kuehn, Sabrina Reinehr, Gesa Stute, Cara Rodust, Pia Grotegut, Alexander-Tobias Hensel, H Burkhard Dick, Stephanie C Joachim
It is known that intravitreally injected N-methyl-d-aspartate (NMDA) leads to fast retina and optic nerve degeneration and can directly activate microglia. Here, we analyzed the relevance for microglia related degenerating factors, the proteins of the complement system, at a late stage in the NMDA damage model. Therefore, different doses of NMDA (0 (PBS), 20, 40, 80 nmol) were intravitreally injected in rat eyes. Proliferative and activated microglia/macrophages (MG/Mϕ) were found in retina and optic nerve 2 weeks after NMDA injection...
May 5, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29738791/altered-gene-expression-pattern-indicates-the-differential-regulation-of-the-immune-response-system-as-an-important-factor-in-cardiac-aging
#12
Babett Bartling, Katja Niemann, Rainer U Pliquett, Hendrik Treede, Andreas Simm
Numerous changes occur in the old myocardium which finally cause lower cardiac output and, therefore, circulatory dysfunction. In order to identify an age-related gene expression pattern, we analyzed left ventricular myocardium of adult (6 months) and old (24 months) mice by use of whole genome expression arrays. About 2.3% of genes expressed above the median value of all genes were differentially expressed in old hearts. Nearly all of them were upregulated. After application of defined exclusion criteria, 98 genes were selected for a more detailed analysis...
May 5, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29737057/-clinicopathological-analysis-of-autoimmune-hepatitis-with-sj%C3%A3-gren-s-syndrome
#13
Lin-Lin Zhu, Li-Hua Yang, Qi-Bing Xie, Geng Yin
OBJECTIVE: To explore the biochemical-immune and pathological characteristics of autoimmune hepatitis (AIH) with Sjögren's syndrome (SS) . METHODS: A total of 76 cases of AIH patients were included from January 2009 to April 2017. Among them,there were 40 cases of AIH with SS and 36 cases without SS. The liver function,immunological index,histological features,length of first diagnosis and treatment costs were compared between the two groups. RESULTS: For AIH+SS group and AIH group,the proportion of women were 97...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29737056/-correlation-of-thyroid-autoantibodies-system-lupus-erythematosus-immunologic-indicators-and-disease-activity-in-sle-with-ht
#14
Huan Liu, Li-Hua Yang, Geng Yin, Qi-Bing Xie
OBJECTIVE: To investigate the correlation of disease activity and thyroid indicators ,immunologic markers of system lupus erythematosus (SLE) in SLE with Hashimoto's thyroiditis (HT). METHODS: The clinical data of 63 cases of SLE with HT were collected. According to Systemic lupus erythematosus disease activity index 2000 (SLEDAI-2000),we classified the patients into four groups,which were remission group (5 cases),low (19 cases),moderate (12 cases) and high (27 cases) disease activity group...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29733960/effects-of-dietary-glucose-and-starch-levels-on-the-growth-apparent-digestibility-and-skin-associated-mucosal-non-specific-immune-parameters-in-juvenile-blunt-snout-bream-megalobrama-amblycephala
#15
Si-Lei Xia, Xiang-Fei Li, Kenneth Prudence Abasubong, Chao Xu, Hua-Juan Shi, Wen-Bin Liu, Ding-Dong Zhang
A 10-week feeding trial was performed to evaluate the effects of different types and levels of carbohydrates in growth performance, apparent digestibility coefficients and skin-associated mucosal non-specific immune parameters in blunt snout bream (Megalobrama amblycephala). Fish were randomly fed four diets containing two carbohydrates (glucose and starch) diets and two carbohydrates levels (330 and 440 g kg-1 ). High carbohydrate levels remarkably increased the weight gain rate (WGR), apparent digestibility of dry matters, protein and carbohydrates, body crud protein content, plasma levels of aspartate transaminase (AST), and skin-associated mucosal levels of immunoglobulin M (IgM), HDL cholesterol, lysozyme (LZM), advanced the transcriptions of mucin 2 (Muc2), mucin 5b (Muc5b) and apolipoprotein A-I (apoA-I), whereas the opposite was true for feed conversion ratio (FCR), plasma levels of IgM, skin-associated mucosal levels of major histocompatibility complex (MHC) and β-Defensins, and the transcriptions of heat shock protein 60 (Hsp60)...
May 4, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29732947/pulmonary-hypofunction-due-to-calcium-carbonate-nanomaterial-exposure-in-occupational-workers-a-cross-sectional-study
#16
Guoliang Li, Lihong Liang, Jingchao Yang, Lihai Zeng, Zhiwei Xie, Yizhou Zhong, Xiaolin Ruan, Ming Dong, Zhanhong Yang, Guanchao Lai, Weixin Huang, Aichu Yang, Jiabing Chen, Banghua Wu, Huaming Xu, Dezhi Meng, Shijie Hu, Lihua Xia, Xingfen Yang, Laiyu Li, Sahoko Ichihara, Gaku Ichihara, Hanlin Huang, Zhenlie Huang
Calcium carbonate nanomaterials (nano-CaCO3 ) are widely used in both manufacturing and consumer products, but their potential health hazards remain unclear. The objective of this study was to survey workplace exposure levels and health effects of workers exposed to nano-CaCO3 . Personal and area sampling, as well as real-time and dust monitoring, were performed to characterize mass exposure, particle size distribution, and particle number exposure. A total of 56 workers (28 exposed workers and 28 unexposed controls) were studied in a cross-sectional study...
May 6, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29731897/hepatitis-b-virus-inhibits-the-expression-of-complement-c3-and-c4-in-vitro-and-in-vivo
#17
Chengliang Zhu, Hui Song, Fengxia Xu, Wei Yi, Fang Liu, Xinghui Liu
The immune system serves an important function in Hepatitis B virus (HBV) infection, and the complement system is a major component of innate immunity. However, the regulatory effect of HBV on complement proteins has not yet been fully elucidated. The present study focused on investigating the impact of HBV on the expression of complement proteins C3 and C4. A total of 226 patients with a clinical diagnosis of HBV infection were enrolled in the study, including 153 with chronic hepatitis B (CHB) and 73 with hepatocellular carcinoma (HCC), whereas 116 healthy individuals were included as a control group...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29729982/c3-glomerulopathy-associated-with-monoclonal-ig-is-a-distinct-subtype
#18
Aishwarya Ravindran, Fernando C Fervenza, Richard J H Smith, Sanjeev Sethi
Monoclonal immunoglobulins (MIg) may play a causal role in C3 glomerulopathy (C3G) by impairing regulation of the alternative pathway of complement. Ninety-five patients with C3G were tested for MIg of which 36 were positive. Their mean age at diagnosis was 60 years and among patient 50 years and older, 65.1% had a MIg. At presentation, median serum creatinine and proteinuria were 1.9 mg/dL and 3.0 g/24 hours. Hematuria was present in 32 (88.9%) patients. Twelve (34.3%) patients had low C3 levels. C3 nephritic factor was detected in 45...
May 2, 2018: Kidney International
https://www.readbyqxmd.com/read/29729575/proteome-analysis-of-the-potential-serum-biomarkers-for-chronic-benzene-poisoning
#19
Zhimin Zhang, Peimao Li, Dafeng Lin, Dianpeng Wang, Yanfang Zhang
The aim of our study is to seek novel specific biomarkers which could provide clues to the mechanism of chronic benzene poisoning (CBP) and might also be used as specific markers for early detection and diagnosis. In this study, a comparative serological proteome analysis between normal controls and CBP patients at three different levels of poisoning were performed via a 2D-DIGE and MALDI-TOF-MS. As the result a total of 10 proteins were found significantly altered between the normal and the mild, moderate and severe poisoning...
April 27, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29729435/complement-c3-opsonization-of-chlamydia-trachomatis-facilitates-uptake-in-human-monocytes
#20
Mads Lausen, Gunna Christiansen, Nichlas Karred, Robert Winther, Thomas Bouet Guldbæk Poulsen, Yaseelan Palarasah, Svend Birkelund
Chlamydia trachomatis is an obligate intracellular bacterium that causes severe infections, which can lead to infertility and ectopic pregnancy. Although both innate and adaptive immune responses are elicited during chlamydial infection the bacterium succeeds to evade host defense mechanisms establishing chronic infections. Thus, studying the host-pathogen interaction during chlamydial infection is of importance to understand how C. trachomatis can cause chronic infections. Both the complement system and monocytes play essential roles in anti-bacterial defense, and, therefore, we investigated the interaction between the complement system and the human pathogens C...
May 2, 2018: Microbes and Infection
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