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https://www.readbyqxmd.com/read/29774091/sensitive-molecular-detection-of-small-nodal-metastasis-in-uterine-cervical-cancer-using-hpv16-e6-ck19-muc1-cancer-biomarkers
#1
Vanessa Samouëlian, Nawel Mechtouf, Eric Leblanc, Guillaume B Cardin, Valérie Lhotellier, Denis Querleu, Françoise Révillion, Francis Rodier
Metastatic nodal involvement is a critical prognostic factor in uterine cervical cancer (UCC). To improve current methods of detecting UCC metastases in lymph nodes (LNs), we used quantitative PCR (qPCR) to assess mRNA expression of potential metastatic biomarkers. We found that expression of HPV16-E6, cytokeratin19 (CK19), and mucin1 (MUC1) is consistently upregulated in tumors and metastatic tissues, supporting a role for these genes in UCC progression. These putative biomarkers were able to predict the presence of histologically positive metastatic LNs with respective sensitivities and specificities of 82% and 99% (CK19), 76% and 95% (HPV16-E6), and 76% and 78% (MUC1)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29757873/management-of-vertebral-metastasis-in-patients-with-uterine-cervical-cancer
#2
Mustafa Kocaer, Varol Gülseren, İsa Aykut Özdemir, Özgü Güngördük, Emre Merter Mart, Muzaffer Sanci, Kemal Güngördük
AIM: We sought to identify risk factors and management options for uterine cervical cancer (UCC) patients with a vertebral metastasis (VM) treated over the course of 23 years. METHODS: Among 844 UCC patients, 18 were diagnosed with a VM. Thirty-six control patients with UCC but without recurrence were matched to these 18 in terms of stage and histological tumor type using a dependent random sampling method. A logistic regression analysis was used to identify factors prognostic of VM; the results are presented as odds ratios with 95% confidence intervals (CIs)...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29736094/influence-of-plasminogen-activator-inhibitor-1-gene-polymorphism-on-renal-scarring-after-first-febrile-urinary-tract-infection-in-infants
#3
Danka Pokrajac, Lejla Kapur-Pojskic, Sandra Vegar-Zubovic, Renata Milardovic
Background: The pathogenesis of renal scarring (RS) after first febrile urinary tract infection (UTI) in children is multifactorial. In addition to well-known risk factors, a role for genetic predisposition has been suggested. Aims: To determine whether deoxyribonucleic acid (DNA) polymorphisms at the plasminogen activator inhibitor -1 (PAI-1) gene were associated with evolution to RS following a febrile UTI in infants. Materials and Methods: Our research included 100 infants, 84 girls and 16 boys, ages up to 1 year with a first febrile UTI, increased inflammatory parameters and positive urine culture treated at the Pediatric Clinic II of the University Clinical Center Sarajevo (UCCS)...
April 2018: Medical Archives
https://www.readbyqxmd.com/read/29732623/upconversion-cross-correlation-spectroscopy-of-a-sandwich-immunoassay
#4
Satu Lahtinen, Stefan Krause, Riikka Arppe, Tero Soukka, Tom Vosch
Fluorescence correlation and cross-correlation spectroscopy (FCS/FCCS) have enabled biologists to study processes of transport, binding and enzymatic reactions in living cells. However, applying FCS and FCCS to samples such as whole blood and plasma is complicated as the fluorescence bursts of diffusing labels can be swamped by strong autofluorescence. Here we present cross-correlation spectroscopy based on two upconversion nanoparticles emitting at different wavelengths on the anti-Stokes side of a single excitation laser...
May 7, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29677493/polyamine-control-of-translation-elongation-regulates-start-site-selection-on-antizyme-inhibitor-mrna-via-ribosome-queuing
#5
Ivaylo P Ivanov, Byung-Sik Shin, Gary Loughran, Ioanna Tzani, Sara K Young-Baird, Chune Cao, John F Atkins, Thomas E Dever
Translation initiation is typically restricted to AUG codons, and scanning eukaryotic ribosomes inefficiently recognize near-cognate codons. We show that queuing of scanning ribosomes behind a paused elongating ribosome promotes initiation at upstream weak start sites. Ribosomal profiling reveals polyamine-dependent pausing of elongating ribosomes on a conserved Pro-Pro-Trp (PPW) motif in an inhibitory non-AUG-initiated upstream conserved coding region (uCC) of the antizyme inhibitor 1 (AZIN1) mRNA, encoding a regulator of cellular polyamine synthesis...
April 19, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29660462/anti-helicobacterpylori-effectiveness-and-targeted-delivery-performance-of-amoxicillin-uccs-2-tpp-nanoparticles-based-on-ureido-modified-chitosan-derivative
#6
Zi-Wei Jing, Min Luo, Yi-Yang Jia, Chen Li, Si-Yuan Zhou, Qi-Bing Mei, Bang-Le Zhang
The amoxicillin-UCCs-2/TPP nanoparticles constructed with ureido-modified chitosan derivative UCCs-2 and sodium tripolyphosphate (TPP) played an important role to deliver drug to achieve more efficacious and specific eradication of Helicobacterpylori (H. pylori) in vitro. In this study, the anti-H. pylori effectiveness in vivo and uptake mechanism was investigated in details, including the effect of temperature, pH values and the addition of competitive substrate urea on uptake. Compared with unmodified nanoparticles, a more efficacious and specific anti-H...
April 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29609855/influenza-vaccine-availability-at-urgent-care-centers-in-the-state-of-arizona
#7
Norman L Beatty, Kelly M Hager, Kyle R McKeown, Francisco Mora, Kathryn R Matthias, David E Nix, Mayar Al Mohajer
We surveyed urgent care centers (UCCs) in the state of Arizona to determine whether they offered the influenza vaccine during the 2016-2017 influenza season. Overall vaccine availability was 80.3% at these facilities. During this season, one-third of the UCCs offered influenza vaccination to children 6 months or older; approximately two-thirds offered influenza vaccination to children and young adults 16 years or older. This is the first study of influenza vaccine availability at UCCs.
March 30, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29580321/salinivirga-fredricksonii-gen-nov-sp-nov-a-heterotrophic-halophile-isolated-from-a-photosynthetic-mat-a-member-of-a-novel-lineage-salinarimonadaceae-fam-nov-within-the-order-rhizobiales-and-reclassification-of-the-genus-salinarimonas-liu-et-al-2010-into-salinarimonadaceae
#8
Jessica K Cole, Beau R Morton, Hayley C Cardamone, Hannah R R Lake, Alice C Dohnalkova, Young-Mo Kim, Jennifer E Kyle, Yukari Maezato, Karl L Dana, Thomas O Metz, Margaret F Romine, William C Nelson, Stephen R Lindemann
A halophilic bacterial strain, HL-109T , was isolated from the unicyanobacterial consortium UCC-O, which was obtained from the photosynthetic mat of Hot Lake (Washington, USA). A polyphasic approach using phenotypic, genotypic and chemotaxonomic data was used to classify the strain within the order Rhizobiales. The organism stained Gram-negative and was a moderate thermophile with a growth optimum of 45 °C. It was obligately aerobic, heterotrophic and halophilic, growing in both NaCl and MgSO4 brines. The novel isolate had a polymorphic cellular morphology of short rods with occasional branching, and cells were monotrichous...
March 26, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29554849/accelerating-stroke-recovery-body-structures-and-functions-activities-participation-and-quality-of-life-outcomes-from-a-large-rehabilitation-trial
#9
Rebecca Lewthwaite, Carolee J Winstein, Christianne J Lane, Sarah Blanton, Burl R Wagenheim, Monica A Nelsen, Alexander W Dromerick, Steven L Wolf
BACKGROUND: Task-oriented therapies have been developed to address significant upper extremity disability that persists after stroke. Yet, the extent of and approach to rehabilitation and recovery remains unsatisfactory to many. OBJECTIVE: To compare a skill-directed investigational intervention with usual care treatment for body functions and structures, activities, participation, and quality of life outcomes. METHODS: On average, 46 days poststroke, 361 patients were randomized to 1 of 3 outpatient therapy groups: a patient-centered Accelerated Skill Acquisition Program (ASAP), dose-equivalent usual occupational therapy (DEUCC), or usual therapy (UCC)...
February 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29551428/most-transfers-from-urgent-care-centers-to-emergency-departments-are-discharged-and-many-are-unnecessary
#10
Tony Zitek, Ignasia Tanone, Alexzza Ramos, Karina Fama, Ahmed S Ali
BACKGROUND: Urgent care centers (UCCs) can offer a cheap alternative to emergency departments (EDs) for some patients with acute complaints. However, if patients who initially present to a UCC are unnecessarily transferred to an ED, those patients may suffer undue financial harm. The group of patients transferred from UCCs to EDs have never previously been studied. OBJECTIVES: The primary objective of this study was to determine the fraction of transfers from a UCC to an ED that were unnecessary...
March 15, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29532409/protein-expression-analysis-in-uterine-cervical-cancer-for-potential-targets-in-treatment
#11
Sugela Blancas, Rogelio Medina-Berlanga, Liliana Ortíz-García, Alfredo Loredo-Ramírez, Leticia Santos
Specific markers in lesions of the human uterine cervix cancer (UCC) are still needed for prognostic, diagnostic and/or therapeutic purposes. In this study we evaluated key molecules at protein level between normal epithelium, cervical intraepithelial neoplasia (CIN1-3) and invasive cancer of a group of molecules previously reported at mRNA level. For that purpose, human formalin-fixed paraffin embedded tissue microarrays (TMAs) were constructed containing 205 Mexican tissue core specimens. Immunohistochemistry and quantitative analysis of histological staining was performed against twenty-two distinct proteins for each core and the processing platform ImageJ...
March 12, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29530174/do-out-of-hours-general-practitioner-services-and-emergency-departments-cost-more-by-collaborating-or-by-working-separately-a-cost-analysis
#12
Sjoerd Broekman, Elisabeth Van Gils-Van Rooij, Berthold Meijboom, Dingenus De Bakker, Christoffel Yzermans
INTRODUCTION In the Netherlands, general practitioners (GPs) and emergency departments (EDs) collaborate increasingly in urgent care collaborations (UCCs) in which the two services share one combined entrance and joint triage. AIM The objective of this study is to determine if UCCs are cost-effective compared to the usual care setting where out-of-hours GP services and EDs work separately. METHODS This observational study compared UCCs with the usual care setting on costs by performing linear regression analyses...
September 2017: Journal of Primary Health Care
https://www.readbyqxmd.com/read/29454378/do-employees-benefit-from-collaborations-between-out-of-hours-general-practitioners-and-emergency-departments
#13
Elisabeth Sybilla Johanna van Gils-van Rooij, Sjoerd Michael Broekman, Dingenus Herman de Bakker, Berthold Rudy Meijboom, Christoffel Joris Yzermans
BACKGROUND: In an attempt to redirect patients who are inappropriately attending hospital emergency departments (ED) and in doing so provide the right care at the right place, out-of-hours GP (General Practitioner) services and EDs increasingly collaborate in Urgent Care Collaborations (UCCs). Work satisfaction is an important factor in analysing the impact of this organisational change. The objective of this study is, firstly, to discover if there is a difference in the employee experiences between those working in UCCs and those in traditional out-of-hours services in which EDs and out-of-hours GP services operate separately (i...
February 17, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29446079/dietary-intake-of-nutrients-involved-in-one-carbon-metabolism-and-risk-of-urothelial-cell-carcinoma-a-prospective-cohort-study
#14
Pierre-Antoine Dugué, Maree T Brinkman, Allison M Hodge, Julie K Bassett, Damien Bolton, Anthony Longano, John L Hopper, Melissa C Southey, Dallas R English, Roger L Milne, Graham G Giles
Nutrients involved in one-carbon metabolism may play a role in carcinogenesis through DNA replication, repair and methylation mechanisms. Most studies on urothelial cell carcinoma (UCC) have focused on folate. We sought to examine the association between B-group vitamins and methionine intake and UCC risk, overall and by subtype, and to test whether these associations are different for population subgroups whose nutritional status may be compromised. We followed participants in the Melbourne Collaborative Cohort Study (N = 41,513) for over 20 years and observed 500 UCC cases (89% originating in the bladder; superficial: 279, invasive: 221)...
February 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29424492/urgent-care-centre-redirection-evaluation-of-a-nurse-led-intervention
#15
Nicola Groom, Tara Kidd, Nicola Carey
AIM: Patient redirection can help reduce service demand by providing information about more appropriate services. There is, however, no evidence about the effect of nurse-led patient redirection in urgent care centre settings. The aim of this project was to develop and evaluate a nurse-led patient 'self-care and redirection first' intervention in an urgent care centre (UCC). METHOD: Adopting a prospective observational design, the intervention was delivered to an opportunity sample of patients who attended a south London hospital UCC, between June and July 2014, and evaluated through patient interviews five to ten days after initial attendance...
February 9, 2018: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/29370874/international-practices-in-the-dietary-management-of-fructose-1-6-biphosphatase-deficiency
#16
A Pinto, M Alfadhel, R Akroyd, Y Atik Altınok, S M Bernabei, L Bernstein, G Bruni, G Caine, E Cameron, R Carruthers, B Cochrane, A Daly, F de Boer, S Delaunay, A Dianin, M Dixon, E Drogari, S Dubois, S Evans, J Gribben, G Gugelmo, C Heidenborg, I Hunjan, I L Kok, B Kumru, A Liguori, D Mayr, E Megdad, U Meyer, R B Oliveira, A Pal, A Pozzoli, R Pretese, J C Rocha, S Rosenbaum-Fabian, J Serrano-Nieto, E Sjoqvist, C Timmer, L White, T van den Hurk, M van Rijn, H Zweers, M Ziadlou, A MacDonald
BACKGROUND: In fructose 1,6 bisphosphatase (FBPase) deficiency, management aims to prevent hypoglycaemia and lactic acidosis by avoiding prolonged fasting, particularly during febrile illness. Although the need for an emergency regimen to avoid metabolic decompensation is well established at times of illness, there is uncertainty about the need for other dietary management strategies such as sucrose or fructose restriction. We assessed international differences in the dietary management of FBPase deficiency...
January 25, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29367052/construction-and-optimization-of-ph-sensitive-nanoparticle-delivery-system-containing-plga-and-uccs-2-for-targeted-treatment-of-helicobacter-pylori
#17
Min Luo, Yi-Yang Jia, Zi-Wei Jing, Chen Li, Si-Yuan Zhou, Qi-Bing Mei, Bang-Le Zhang
The acidic environment of the stomach is a threat to the curative effect of antimicrobial drugs for the eradication of Helicobacter pylori (H. pylori) in the infected area. The conventional clinical formulations of antibiotics have low specificity to H. pylori, which disrupts the normal balance of intestinal microbiomes. Therefore, oral drug delivery system with better stability at low pH as well as higher specificity to target H. pylori would provide more effective strategy to eradicate H. pylori and reduce the side effect of antibiotics...
April 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29343911/oncologic-outcomes-in-patients-with-nonurothelial-bladder-cancer
#18
Sanjay G Patel, Adam Benjamin Weiner, Kirk Keegan, Todd Morgan
Introduction: We aimed to evaluate the relative prognostic impact of the most common variant histologies on disease-specific survival (DSS) in patients undergoing radical cystectomy. Materials and Methods: The Surveillance, Epidemiology, and End Result database was used to identify patients who underwent radical cystectomy for bladder cancer from 1990 to 2007. Patients with urothelial cell carcinoma (UCC), squamous cell carcinoma (SCC), adenocarcinoma (AC), sarcoma, small cell carcinoma, signet ring carcinoma, and spindle cell carcinoma were included in the study...
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29288742/the-research-of-the-possible-mechanism-and-the-treatment-for-capsaicin-induced-cough
#19
Li Zhang, Tieying Sun, Longteng Liu, Lifang Wang
Unexplained chronic cough (UCC) affects millions of patients worldwide. New therapeutic approaches to this condition are urgently needed, since current treatment options provide only symptomatic relief. Cough reflex hypersensitivity has been shown to play an important role in the pathogenesis of UCC. The transient receptor potential vanilloid type 1 (TRPV1) is present on peripheral terminals of airway sensory nerves and modulation of its activity represents a potential target for the pharmacological treatment of UCC...
April 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29284900/impact-of-preoperative-anxiety-in-patients-on-hemodynamic-changes-and-a-dose-of-anesthetic-during-induction-of-anesthesia
#20
Jasmina Ahmetovic-Djug, Sefik Hasukic, Haris Djug, Begzada Hasukic, Alan Jahic
Objectives: Each surgical patient is preoperatively, intraoperatively and postoperatively exposed to stress. The aim of this study was to determine the existence of preoperative anxiety, and to determine its impact on hemodynamic parameters (blood pressure, heart rate) in patients and dose of anesthetics during induction of anesthesia. Methods: A prospective clinical study conducted at the Department of Anesthesiology and Reanimation and Surgery Clinic of University Clinical Center Tuzla (UCC) in the period May 2012...
October 2017: Medical Archives
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