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https://www.readbyqxmd.com/read/28628011/-criteria-for-selection-of-tumor-cells-and-prospects-for-specific-immunotherapy-for-bladder-cancer
#1
T Slavyanskaya, S -Salnikova, R Sepiashvili
Specific antitumor immunotherapy with autologous dendritic cell vaccines is one of the new approaches of modern medicine. For activation of dendritic cells highly immunogenic antigens are used, however optimal antigens in case of bladder cancer (BC) are still not researched. Cancer-testis antigens (CTA) are the most promising target in the context of creation of antitumor vaccines, because they are distinguished by pronounced immunogenicity, they are detected in different types of tumors and have limited pattern of expression in healthy tissues of grown-up organism...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28628010/-the-main-stages-of-the-preparation-of-viable-tumor-cells-of-bladder-cancer-from-isolation-of-the-tumor-material-till-cryopreservation-of-cell-lines
#2
T Slavyanskaya, S -Salnikova
The development of personalized autologous dendritic cell anti-tumor vaccines (PDPW) against bladder cancer (BC) is a relevant issue that covers many aspects required for its standardization. The article presents personal experimental studies related to development of optimal conditions of transportation of biological material; temperature and temporary modes for the storage of the samples; the materials about the optimal method of disaggregation of the biomaterial; there has been shown a comparative analysis of different methods of tumor disaggregation; the selection of nutritious growth mediums and growth factors for urothelial carcinoma cells (UCC), the conditions of cryopreservation of tumor cells for maximum UCC viability, potentially suitable for creating PDPW against BC...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28622405/implementing-a-randomized-controlled-trial-through-a-community-academia-partnered-participatory-research-arte-con-salud-research-informed-intervention
#3
Patricia Noboa-Ortega, Wanda I Figueroa-Cosme, Alana Feldman-Soler, Christine Miranda-Díaz
OBJECTIVE: "Arte con Salud" is an HIV/AIDS prevention intervention tailored for Puerto Rican women who have sex with men. The intervention curriculum was refined through a community-academic collaboration between Taller Salud, the UPRCayey Campus, and the UCC-School of Medicine, subsided in 2012-13 by PRCTRC. The collaboration has been crucial to validate the impact of using art as a tool to facilitate sexual negotiation skills and safer sexual practices among adult women have sex with men participating in HIV prevention education...
June 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28621161/dna-methylation-patterns-in-ulcerative-colitis-associated-cancer-a-systematic-review
#4
Ruth A Emmett, Katherine L Davidson, Nicholas J Gould, Ramesh P Arasaradnam
BACKGROUND: Evidence points to the role of DNA methylation in ulcerative colitis (UC) associated cancer (UCC), the most serious complication of ulcerative colitis. A better understanding of the etiology of UCC may facilitate the development of new therapeutic targets and help to identify biomarkers of the disease risk. METHODS: A search was performed in three databases following PRISMA protocol. DNA methylation in UCC was compared with sporadic colorectal cancer (SCRC), and individual genes differently methylated in UCC identified...
June 16, 2017: Epigenomics
https://www.readbyqxmd.com/read/28578361/current-umbilical-cord-clamping-practices-and-attitudes-of-obstetricians-and-midwives-toward-delayed-cord-clamping-in-saudi-arabia
#5
Nadia O Ibrahim, Hatouf H Sukkarieh, Rami T Bustami, Elaf A Alshammari, Lama Y Alasmari, Hanan M Al-Kadri
BACKGROUND: In Saudi Arabia, as in many countries, there is usually no clear definition of the timing of umbilical cord clamping (UCC) in the policies and procedures used by hospitals. The World Health Organization (WHO) recommends delayed cord clamping (DCC) ( > 1 minute after birth) as it can significantly improve hemodynamics and long-term neurodevelopment. OBJECTIVE: To investigate current practices of healthcare professionals on the timing of UCC in Saudi Arabia...
May 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28551413/applying-the-chicken-embryo-chorioallantoic-membrane-assay-to-study-treatment-approaches-in-urothelial-carcinoma
#6
Margaretha A Skowron, Anuja Sathe, Andrea Romano, Michèle J Hoffmann, Wolfgang A Schulz, Gommert A van Koeveringe, Peter Albers, Roman Nawroth, Günter Niegisch
BACKGROUND: Rapid development of novel treatment options demands valid preclinical screening models for urothelial carcinoma (UC). The translational value of high-throughput drug testing using 2-dimensional (2D) cultures is limited while for xenograft models handling efforts and costs often become prohibitive for larger-scale drug testing. Therefore, we investigated to which extent the chicken chorioallantoic membrane (CAM) assay might provide an alternative model to study antineoplastic treatment approaches for UC...
May 25, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28524154/an-analysis-of-the-polymorphisms-of-the-glut1-gene-in-urothelial-cell-carcinomas-of-the-bladder-and-its-correlation-with-p53-ki67-and-glut1-expressions
#7
C Xu, X Yang, Y Wang, N Ding, R Han, Y Sun, Y Wang
Frequencies of two glucose transporter 1 (GLUT1) single-nucleotide polymorphisms (SNPs) (XbaI G>T and HaeIII T>C) were studied with urothelial cell carcinomas of the bladder (UCC) and 204 normal persons. And the expression of the p53, Ki67 and GLUT1 was assayed by immunohistochemistry. The frequency of the TT genotype and T allele of the XbaI G>T SNP was decreased in the patients with UCC. The frequency of the CC genotype and C allele of the HaeIII T>C SNP was decreased in the patients with UCC...
May 19, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28492554/the-novel-long-intergenic-noncoding-rna-ucc-promotes-colorectal-cancer-progression-by-sponging-mir-143
#8
Feng-Ting Huang, Wen-Ying Chen, Zhi-Qiang Gu, Yan-Yan Zhuang, Chu-Qiang Li, Ling-Yun Wang, Juan-Fei Peng, Zhe Zhu, Xin Luo, Yuan-Hua Li, He-Rui Yao, Shi-Neng Zhang
The human genome contains thousands of long intergenic noncoding RNAs (lincRNAs). However, the functional roles of these transcripts and the mechanisms responsible for their deregulation in colorectal cancer (CRC) remain elusive. A novel lincRNA termed upregulated in CRC (UCC) was found to be highly expressed in human CRC tissues and cell lines. UCC levels correlated with lymph node metastasis, Dukes' stage, and patient outcomes. In SW480 and SW620 cells, knockdown of UCC inhibited proliferation, invasion, and cell cycle progression and induced apoptosis in vitro...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28484359/evaluation-of-congenital-heart-defects-treatment-options-establishment-of-pediatric-cardiology-cardiosurgery-in-bosnia-and-herzegovina
#9
REVIEW
Zijo Begic, Sanko Pandur, Edo Omerbasic, Almira Kadic, Mirza Halimic
INTRODUCTION: Modern pediatric cardiology mainly deals with congenital heart defects (CHD), as the most common congenital anomalies. In most cases CHD requires surgical or interventional treatment. GOAL: The goal of the research was to evaluate CHD treatment at Pediatric Clinic, University Clinical Center (UCC) Sarajevo, Bosnia and Herzegovina (B&H). UCC Sarajevo is the only institution in B&H where cardiac treatment of CHD in pediatric population is performed. Pediatric cardiosurgery has started to develop in Bosnia and Herzegovina in April 1997...
March 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28375927/impact-of-chemotherapy-and-radiotherapy-on-management-of-early-stage-clear-cell-and-papillary-serous-carcinoma-of-the-uterus
#10
Julian C Hong, Jonathan Foote, Gloria Broadwater, Stéphanie Gaillard, Laura J Havrilesky, Junzo P Chino
OBJECTIVE: The aim of the study was to assess interaction of lymph node dissection (LND), adjuvant chemotherapy (CT), and radiotherapy (RT) in stage I uterine papillary serous carcinoma (UPSC) and uterine clear cell carcinoma (UCC). METHODS/MATERIALS: The National Cancer Data Base was queried for women diagnosed with International Federation of Gynecology and Obstetrics stage I UPSC and UCC from 1998 to 2012. Overall survival (OS) was estimated for combinations of RT and CT by the Kaplan-Meier method stratified by histology and LND...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28356947/downregulation-of-feline-sarcoma-related-protein-inhibits-cell-migration-invasion-and-epithelial-mesenchymal-transition-via-the-erk-ap-1-pathway-in-bladder-urothelial-cell-carcinoma
#11
Xudong Hu, Zhiqiang Zhang, Zhaofeng Liang, Dongdong Xie, Tao Zhang, Dexin Yu, Caiyun Zhong
Feline sarcoma-related protein (Fer) is a nuclear and cytoplasmic non-receptor protein tyrosine kinase and Fer overexpression is associated with various biological processes. However, the clinicopathological characteristics and molecular mechanisms of Fer expression in bladder urothelial cell carcinoma (UCC) have yet to be elucidated. The present study demonstrated that Fer was significantly upregulated in bladder UCC tissues and cell lines. A clinicopathological analysis suggested that Fer expression was significantly associated with tumor stage, histological grade and lymph node status, and Fer expression was a prognostic factor for overall survival in a multivariate analysis...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28315231/toxic-elements-in-the-stream-sediments-of-an-urbanized-basin-eastern-china-urbanization-greatly-elevates-their-adverse-biological-effects
#12
Pengbao Wu, Aijing Yin, Xiaohui Yang, Huan Zhang, Manman Fan, Chao Gao
The concentration of toxic elements (Hg, Cd, Cr, Cu, Pb, Zn, Ni and As) was measured in the sediments of the Qinhuai River in Eastern China along a rural to urban gradient. Multiple approaches were undertaken to evaluate the degree of enrichment and adverse biological effects of these elements. The results showed that the concentration of Hg, Cd, Zn, Cu and Pb increased exponentially from the agricultural headwater to the urbanized downstream, which reflects a severe anthropogenic influence. In addition, area-specific references, such as the local soil background (LSB) and upper continental crust (UCC) derived from the Yangtze craton, were more applicable for evaluating the enrichment of toxic elements in the Qinhuai River than was global UCC...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28314276/evodiamine-induces-cell-growth-arrest-apoptosis-and-suppresses-tumorigenesis-in-human-urothelial-cell-carcinoma-cells
#13
Chung-Sheng Shi, Jhy-Ming Li, Chih-Chien Chin, Yi-Hung Kuo, Ying-Ray Lee, Yun-Ching Huang
BACKGROUND/AIM: Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities including vasodilatation, analgesia, anti-cardiovascular disease, anti-Alzheimer's disease, anti-inflammation, and anti-tumor activity. MATERIALS AND METHODS: This study analyzes the anti-tumor effects of evodiamine on cellular growth, tumorigenesis, cell cycle and apoptosis induction of human urothelial cell carcinoma (UCC) cells. RESULTS: The present study showed that evodiamine significantly inhibited the proliferation of UCC cells in a dose- and time-dependent manner...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28250962/the-herts-and-minds-study-evaluating-the-effectiveness-of-mentalization-based-treatment-mbt-as-an-intervention-for-children-in-foster-care-with-emotional-and-or-behavioural-problems-a-phase-ii-feasibility-randomised-controlled-trial
#14
Nick Midgley, Sarah Jane Besser, Helen Dye, Pasco Fearon, Tim Gale, Kiri Jefferies-Sewell, Karen Irvine, Joyce Robinson, Solange Wyatt, David Wellsted, Sally Wood
BACKGROUND: A significant proportion of children in the social care system in England present with mental health problems, with the majority experiencing some form of emotional and behavioural difficulties. The most effective treatments for these children are currently unknown, partly due to a lack of robust, controlled studies. Researchers have identified a number of obstacles to conducting well-designed research with this population, making the need to test the feasibility of a randomised controlled trial especially important...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28238939/unitary-circular-code-motifs-in-genomes-of-eukaryotes
#15
Karim El Soufi, Christian J Michel
A set X of 20 trinucleotides was identified in genes of bacteria, eukaryotes, plasmids and viruses, which has in average the highest occurrence in reading frame compared to its two shifted frames (Michel, 2015; Arquès and Michel, 1996). This set X has an interesting mathematical property as X is a circular code (Arquès and Michel, 1996). Thus, the motifs from this circular code X, called X motifs, have the property to always retrieve, synchronize and maintain the reading frame in genes. The origin of this circular code X in genes is an open problem since its discovery in 1996...
February 24, 2017: Bio Systems
https://www.readbyqxmd.com/read/28213342/virtual-visits-for-acute-nonurgent-care-a-claims-analysis-of-episode-level-utilization
#16
Aliza S Gordon, Wallace C Adamson, Andrea R DeVries
BACKGROUND: Expansion of virtual health care-real-time video consultation with a physician via the Internet-will continue as use of mobile devices and patient demand for immediate, convenient access to care grow. OBJECTIVE: The objective of the study is to analyze the care provided and the cost of virtual visits over a 3-week episode compared with in-person visits to retail health clinics (RHC), urgent care centers (UCC), emergency departments (ED), or primary care physicians (PCP) for acute, nonurgent conditions...
February 17, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28210012/echocardiographic-parameters-as-life-quality-predictors-in-patients-after-myocardial-infarction-treated-with-different-methods
#17
Alen Dzubur, Mevludin Mekic, Senad Pesto, Naser Nabil
INTRODUCTION: Cardiovascular diseases are the leading cause of death in most countries. The aim was to examine the quality of life and to determine the differences in the quality of life in patients one year after myocardial infarction and the relationship between quality of life and echocardiographic parameters in these patients. MATERIAL AND METHODS: The research was a prospective, clinical, epidemiological study and was conducted at the Clinic of Cardiology, University Clinical Center Sarajevo (UCCS)...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28210010/evaluation-and-treatment-of-anemia-in-premature-infants
#18
Edo Hasanbegovic, Nermana Cengic, Snijezana Hasanbegovic, Jasmina Heljic, Ismail Lutolli, Edin Begic
INTRODUCTION: Anemia in preterm infants is the pathophysiological process with greater and more rapid decline in hemoglobin compared to the physiological anemia in infants. There is a need for transfusions and administration of human recombinant erythropoietin. AIM: To determine the frequency of anemia in premature infants at the Pediatric Clinic, University Clinical Center Sarajevo, as well as parameter values in the blood count of premature infants and to explore a relationship between blood transfusions with the advent of intraventricular hemorrhage (determine treatment outcome in preterm infants)...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28174186/avoiding-misdiagnosis-cystic-calcified-brain-metastases-of-uterine-cervical-cancer-mimicking-neurocysticercosis
#19
Jacopo Fantini, Arianna Sartori, Paolo Manganotti
The radiological finding of multiple calcified brain lesions is atypical for brain metastases and in absence of a clear evidence of disseminated neoplastic disease the differential diagnosis may be difficult. Calcified brain metastases (CBM) are rarely encountered in clinical practice and they mostly arise from lung, breast and gastrointestinal primitive tumours. Only one case of uterine cervical carcinoma (UCC) with CBM has been reported so far. We describe the case of a 41-year-old Caucasian woman with a history of hysterectomy and bilateral salpingo-oophorectomy for UCC 3 years prior to observation and no evidence of neoplastic recurrence that developed cystic CBM...
February 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28128643/uniform-data-collection-in-routine-clinical-practice-in-cardiovascular-patients-for-optimal-care-quality-control-and-research-the-utrecht-cardiovascular-cohort
#20
Folkert W Asselbergs, Frank Lj Visseren, Michiel L Bots, Gert J de Borst, Marc P Buijsrogge, Jan M Dieleman, Baukje Gf van Dinther, Pieter A Doevendans, Imo E Hoefer, Monika Hollander, Pim A de Jong, Steven V Koenen, Gerard Pasterkamp, Ynte M Ruigrok, Yvonne T van der Schouw, Marianne C Verhaar, Diederick E Grobbee
Background Cardiovascular disease remains the major contributor to morbidity and mortality. In routine care for patients with an elevated cardiovascular risk or with symptomatic cardiovascular disease information is mostly collected in an unstructured manner, making the data of limited use for structural feedback, quality control, learning and scientific research. Objective The Utrecht Cardiovascular Cohort (UCC) initiative aims to create an infrastructure for uniform registration of cardiovascular information in routine clinical practice for patients referred for cardiovascular care at the University Medical Center Utrecht, the Netherlands...
May 2017: European Journal of Preventive Cardiology
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