keyword
MENU ▼
Read by QxMD icon Read
search

5-hiaa

keyword
https://www.readbyqxmd.com/read/29738870/comparison-of-transitional-vs-surgical-menopause-on-monoamine-and-amino-acid-levels-in-the-rat-brain
#1
Tao Long, Jeffrey K Yao, Junyi Li, Ziv Z Kirshner, Doug Nelson, George G Dougherty, Robert B Gibbs
Loss of ovarian function has important effects on neurotransmitter production and release with corresponding effects on cognitive performance. To date, there has been little direct comparison of the effects of surgical and transitional menopause on neurotransmitter pathways in the brain. In this study, effects on monoamines, monoamine metabolites, and the amino acids tryptophan (TRP) and tyrosine (TYR) were evaluated in adult ovariectomized (OVX) rats and in rats that underwent selective and gradual ovarian follicle depletion by daily injection of 4-vinylcyclohexene-diepoxide (VCD)...
May 5, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29720377/analgesic-effects-of-electroacupuncture-at-st25-and-cv12-in-a-rat-model-of-postinflammatory-irritable-bowel-syndrome-visceral-pain
#2
Xianwei Zhu, Zhibin Liu, Yifei Qin, Wenmin Niu, Qiang Wang, Lu Li, Jing Zhou
BACKGROUND: Treatment with electroacupuncture (EA) at ST25 and CV12 has a significant analgesic effect on postinflammatory irritable bowel syndrome (PI-IBS) visceral pain. Enterochromaffin (EC) cells and serotonin (5-hydroxytryptamine (5-HT)) are important in the development of visceral hyperalgesia. OBJECTIVE: To investigate the analgesic effect and underlying mechanisms of EA at ST25 and CV12 on the treatment of trinitrobenzene sulfonic acid (TNBS)-induced PI-IBS visceral hyperalgesia in rats...
May 2, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29708876/quantification-of-vanillylmandelic-acid-homovanillic-acid-and-5-hydroxyindoleacetic-acid-in-urine-using-a-dilute-and-shoot-and-ultra-high-pressure-liquid-chromatography-tandem-mass-spectrometry-method
#3
Eric Grouzmann, Catherine Centeno, Philippe J Eugster
BACKGROUND: Urinary vanillylmandelic acid (VMA) and homovanillic acid (HVA) are biomarkers for the diagnosis and follow-up of neuroblastoma, whereas urinary 5-hydroxyindoleacetic acid (5-HIAA) is used to assess a carcinoid tumor. These analytes are conventionally analyzed in a single run by chromatography (LC) coupled with electrochemical detection (LC-ECD) using commercial kits. A rapid dilute-and-shoot LC tandem mass spectrometry (LC-MS/MS) assay was validated in order to replace the LC-ECD method and therefore improve analytical specificity and throughput...
May 1, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29696066/metastatic-neuroendocrine-pancreatic-tumor-case-report
#4
E C Radu, A I Saizu, R R Grigorescu, A E Croitoru, C Gheorghe
Rationale. Pancreatic neuroendocrine tumors (NETs) are rare neoplasms that develop from the endocrine tissues of the pancreas. They have a better overall prognosis than pancreatic adenocarcinoma. However, all commonly used classification systems reflect a separation between more indolent, well-differentiated tumors and far more aggressive poorly differentiated types that behave clinically more like small-cell carcinoma of the lung. Objective. To present the case of a 62-year-old man with an aggressive pancreatic NET, with liver, splenic and bone metastases who underwent multidisciplinary treatment including several lines of chemotherapy, somatostatin analogs and radiotherapy...
January 2018: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29618432/effects-of-single-administration-of-apomorphine-on-memory-and-monoamine-metabolism-a-dose-related-study
#5
Huma Ikram, Rumaisa Zakir, Darakhshan Jabeen Haleem
In the present study, we have monitored dose dependent effects of apomorphine on learning and memory. Behavioral sensitization and craving, which develop upon repeated treatment with dopamine receptor agonist apomorphine, are major limitations of the therapeutic use of apomorphine in Parkinson's patients. Effects of single (intraperitoneal) injection of apomorphine at different doses (i.e., 0.5, 1.0, & 2.0 mg/ml/kg) on locomotion in a familiar environment (Skinner's box) and memory in Morris water maze were investigated...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29615861/lead-induced-atypical-parkinsonism-in-rats-behavioral-electrophysiological-and-neurochemical-evidence-for-a-role-of-noradrenaline-depletion
#6
Mariam Sabbar, Claire Delaville, Philippe De Deurwaerdère, Nouria Lakhdar-Ghazal, Abdelhamid Benazzouz
Background: Lead neurotoxicity is a major health problem known as a risk factor for neurodegenerative diseases, including the manifestation of parkinsonism-like disorder. While lead is known to preferentially accumulate in basal ganglia, the mechanisms underlying behavioral disorders remain unknown. Here, we investigated the neurophysiological and biochemical correlates of motor deficits induced by sub-chronic injections of lead. Methods: Sprague Dawely rats were exposed to sub-chronic injections of lead (10 mg/kg, i...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29601911/neuroprotective-effect-of-the-carnosine-%C3%AE-lipoic-acid-nanomicellar-complex-in-a-model-of-early-stage-parkinson-s-disease
#7
O I Kulikova, D S Berezhnoy, S L Stvolinsky, A V Lopachev, V S Orlova, T N Fedorova
In a model of early-stage Parkinson's disease induced by a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to Wistar rats, a neuroprotective effect of a new derivative of carnosine and α-lipoic acid (C/LA nanomicellar complex) was demonstrated. Acute intraperitoneal administration of carnosine, α-lipoic acid and C/LA complex following MPTP administration normalized the total antioxidant activity in the brain tissue. Of all the compounds tested only C/LA complex normalized the metabolism of dopamine (DA) and serotonin (5-HT), while its components did not show similar effects when used separately...
March 27, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29596816/comparison-of-serum-serotonin-and-serum-5-hiaa-lc-ms-ms-assays-in-the-diagnosis-of-serotonin-producing-neuroendocrine-neoplasms-a-pilot-study
#8
Mikael Lindström, Niina Tohmola, Risto Renkonen, Esa Hämäläinen, Camilla Schalin-Jäntti, Outi Itkonen
BACKGROUND: Serotonin (5-hydroxytyramine) is a mediator of gastrointestinal smooth muscle contraction, and is secreted by neuroendocrine neoplasms (NENs). We developed a liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for serum serotonin to be used in NEN diagnostics and follow-up. METHODS: We used serum samples from healthy volunteers (n = 31) and patients suspected or monitored for NEN (n = 98). Serotonin-D4 internal standard was added to samples before solid phase extraction (SPE) and quantification by LC-MS/MS...
March 26, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29577894/bilateral-quinolinic-acid-induced-lipid-peroxidation-decreased-striatal-monoamine-levels-and-neurobehavioral-deficits-are-ameliorated-by-gip-receptor-agonist-d-ala-2-gip-in-rat-model-of-huntington-s-disease
#9
Mahip K Verma, Rajan Goel, Krishnadas Nandakumar, Kumar V S Nemmani
Huntington's disease (HD) is an inherited complex progressive neurodegenerative disorder with an established etiopathology linked to neuronal oxidative stress and corticostriatal excitotoxicity. Present study explores the effects of glucose-dependent insulinotropic polypeptide (GIP) receptor agonist on the neurobehavioral sequelae of quinolinic acid-induced phenotype of Huntington's disease in rats. Bilateral administration of quinolinic acid (300 nmol/4µL) to the rat striatum led to characteristic deficits in, locomotor activity, motor coordination, neuromuscular coordination and short-term episodic memory...
March 22, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29565169/biochemical-and-histological-changes-produced-by-sweeteners-and-cytarabine-in-the-brain-of-young-rats
#10
Ernestina Hernández García, Norma Osnaya Brizuela, Armando Valenzuela Peraza, David Calderón Guzmán, Maribel Ortiz Herrera, Hugo Juárez Olguín, Gerardo Barragán Mejía, Daniel Santamaría Del Ángel, Alberto Rojas Ochoa
OBJECTIVE: The aim of this study was to evaluate the effect of splenda and stevia on dopamine and 5-HIAA levels, and some biomarkers of oxidative stress in the presence of cytarabine. METHODS: Forty-eight young male Wistar rats each with a weight of 80 g (four weeks of age), distributed in six groups of eight animals each, were treated as follows: group 1, control (NaCl 0.9% vehicle); group 2, cytarabine (0.6 g/kg); group 3, stevia (0.6 g/kg); group 4, cytarabine + stevia; group 5, splenda; and group 6, cytarabine + splenda...
February 13, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29561730/improved-serotonergic-neurotransmission-by-genistein-pretreatment-regulates-symptoms-of-obsessive-compulsive-disorder-in-streptozotocin-induced-diabetic-mice
#11
Pradeep Phadnis, Purnima Dey Sarkar, Mithun Singh Rajput
BACKGROUND: Initial evidences have shown that diabetes mellitus occurs concomitantly with obsessive-compulsive disorder (OCD) symptomatology. Serotonergic psychiatric therapy posits that serotonin is a central character in the management of OCD. Hence, it is worth investigating novel chemical entities affecting the serotonergic system for targeting OCD. An isoflavonoid phytoestrogen, genistein, has been recognized as of great pharmacological value especially for protecting neurodegeneration, depression (serotonin regulation), and diabetes...
March 21, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29557530/neuroprotective-efficiency-of-mangifera-indica-leaves-extract-on-cadmium-induced-cortical-damage-in-rats
#12
Naif E Al Omairi, Omyma K Radwan, Yahea A Alzahrani, Rami B Kassab
Due to the high ability of cadmium to cross the blood-brain barrier, cadmium (Cd) causes severe neurological damages. Hence, the purpose of this study was to investigate the possible protective effect of Mangifera indica leaf extract (MLE) against Cd-induced neurotoxicity. Rats were divided into eight groups. Group 1 served as vehicle control group, groups 2, 3 and 4 received MLE (100, 200, 300 mg /kg b.wt, respectively). Group 5 was treated with CdCl2 (5 mg/kg b.wt). Groups 6, 7 and 8 were co-treated with MLE and CdCl2 using the same doses...
March 20, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29527003/a-case-of-carcinoid-syndrome-due-to-malignant-metastatic-carcinoid-tumor-with-carcinoid-heart-disease-involving-four-cardiac-valves
#13
Brianna J Shinn, Laura J Tafe, Pantila Vanichakarn
BACKGROUND Carcinoid tumor, benign, low-grade malignant, and high-grade malignant, can be associated with the release of vasoactive substances that cause symptoms including cutaneous flushing, diarrhea, and bronchospasm. In 50-60% of patients with carcinoid syndrome, the vasoactive substances cause fibrosis of the pulmonary and tricuspid heart valves which lead to regurgitation and right-sided heart failure. The right side of the heart is usually affected because monoamine oxidases in the lungs usually inactivate the vasoactive substances...
March 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29499311/auditory-stimulation-by-exposure-to-melodic-music-increases-dopamine-and-serotonin-activities-in-rat-forebrain-areas-linked-to-reward-and-motor-control
#14
Michele M Moraes, Patrícia C R Rabelo, Valéria A Pinto, Washington Pires, Samuel P Wanner, Raphael E Szawka, Danusa D Soares
Listening to melodic music is regarded as a non-pharmacological intervention that ameliorates various disease symptoms, likely by changing the activity of brain monoaminergic systems. Here, we investigated the effects of exposure to melodic music on the concentrations of dopamine (DA), serotonin (5-HT) and their respective metabolites in the caudate-putamen (CPu) and nucleus accumbens (NAcc), areas linked to reward and motor control. Male adult Wistar rats were randomly assigned to a control group or a group exposed to music...
April 23, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29482043/no-major-influence-of-regular-tobacco-smoking-on-cerebrospinal-fluid-monoamine-metabolite-concentrations-in-patients-with-psychotic-disorder-and-healthy-individuals
#15
Josefin Hjärpe, Erik Söderman, Dimitrios Andreou, Göran C Sedvall, Ingrid Agartz, Erik G Jönsson
Metabolism of the monoamines dopamine, serotonin and noradrenaline, is altered in the central nervous system of people with schizophrenia, and their major metabolites homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), respectively, have been intensively studied as indirect measures of these neurotransmitters in cerebrospinal fluid (CSF). Regular tobacco smoking has been shown to alter neurotransmitter metabolism in the brain and studies have found CSF monoamine metabolite concentrations to be substantially lower in smokers...
May 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29480224/monoaminergic-markers-across-the-cognitive-spectrum-of-lewy-body-disease
#16
Sygrid van der Zee, Yannick Vermeiren, Erik Fransen, Debby Van Dam, Tony Aerts, Marleen J Gerritsen, Jacoba M Spikman, Teus van Laar, Peter P De Deyn
BACKGROUND: Lewy body disorders, including Parkinson's disease (PD), Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), are characterized by profound central and peripheral monoaminergic dysfunction. OBJECTIVE: To investigate whether these alterations depend on dementia status, we measured cerebrospinal fluid (CSF) and serum monoamine and metabolite levels across subgroups of the cognitive spectrum, and evaluated their marker potential afterwards...
2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29477128/development-of-a-diagnostic-method-for-parkinson-s-disease-by-reverse-phase-high-performance-liquid-chromatography-coupled-with-integrated-pulsed-amperometric-detection
#17
Minhwa Oh, Eugene Huh, Myung Sook Oh, Ji-Seon Jeong, Seon-Pyo Hong
We developed a diagnostic method for Parkinson's disease by simultaneously analyzing biogenic amines and their metabolites using reverse-phase high-performance liquid chromatography coupled with integrated pulsed amperometric detection (RP-HPLC-IPAD) method. Dopamine (DA), 3, 4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), 5-hydroxyindolacetic acid (5-HIAA), and homovanillic acid (HVA) were used as biomarkers to diagnose Parkinson's disease. All target components were detected with good sensitivity using sodium hydroxide (as a post-column eluent)...
May 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29456406/health-related-quality-of-life-anxiety-depression-and-impulsivity-in-patients-with-advanced-gastroenteropancreatic-neuroendocrine-tumours
#18
Alexandra R Lewis, Xin Wang, Laurice Magdalani, Paolo D'Arienzo, Colsom Bashir, Was Mansoor, Richard Hubner, Juan W Valle, Mairéad G McNamara
AIM: To compare health-related quality of life (HRQoL), anxiety, depression, and impulsivity scores in patients with and without carcinoid syndrome (CS), and correlated them with serum 5-hydroxyindoleacetic acid (5-HIAA) levels. METHODS: Patients with advanced gastroenteropancreatic neuroendocrine tumours (GEPNET), with and without CS completed HRQoL QLQ-C30 and QLQ-GI.NET21, Hospital Anxiety and Depression Scale (HADS) and Barratt Impulsivity Scale (BIS) questionnaires...
February 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29440231/-ex-vivo-activity-of-cytotoxic-drugs-and-targeted-agents-in-small-intestinal-neuroendocrine-tumors
#19
Kosmas Daskalakis, Olov Norlén, Andreas Karakatsanis, Per Hellman, Rolf Larsson, Peter Nygren, Peter Stålberg
Small intestinal neuroendocrine tumors (SI-NETs) are generally considered resistant to systemic treatment. To date, predictive markers for drug activity are lacking. Tumor samples from 27 patients with SI-NETs were analyzed ex vivo for sensitivity to a panel of cytotoxic drugs and targeted agents using a short-term total cell kill assay. Samples of renal cancer, colorectal cancer (CRC), ovarian cancer and chronic lymphocytic leukemia (CLL) were included for comparison. For the SI-NET subset, drug sensitivity was analyzed in relation to clinicopathological variables and pre-treatment biomarkers...
April 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29427844/seasonality-of-cerebrospinal-fluid-monoamine-metabolite-concentrations-and-their-associations-with-meteorological-variables-in-humans
#20
Timothy D Brewerton, Karen T Putnam, Richard R J Lewine, S Craig Risch
Seasonal variations in neurotransmitter parameters have been previously reported in humans. However, these studies have involved small sample sizes and have not examined possible relationships with meteorological variables. We compared cerebrospinal fluid (CSF) concentrations of the major monoamine neurotransmitter metabolites (5-HIAA, HVA, and MHPG) in 188 healthy controls (80 men, 108 women) in relationship to age, sex, BMI, and available meteorological variables. All subjects had a lumbar puncture (LP) performed at 9 a...
April 2018: Journal of Psychiatric Research
keyword
keyword
8496
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"