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https://www.readbyqxmd.com/read/27228907/natural-lecithin-promotes-neural-network-complexity-and-activity
#1
Shahrzad Latifi, Ali Tamayol, Rouhollah Habibey, Reza Sabzevari, Cyril Kahn, David Geny, Eftekhar Eftekharpour, Nasim Annabi, Axel Blau, Michel Linder, Elmira Arab-Tehrany
Phospholipids in the brain cell membranes contain different polyunsaturated fatty acids (PUFAs), which are critical to nervous system function and structure. In particular, brain function critically depends on the uptake of the so-called "essential" fatty acids such as omega-3 (n-3) and omega-6 (n-6) PUFAs that cannot be readily synthesized by the human body. We extracted natural lecithin rich in various PUFAs from a marine source and transformed it into nanoliposomes. These nanoliposomes increased neurite outgrowth, network complexity and neural activity of cortical rat neurons in vitro...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26229435/targeting-brain-cells-with-glutathione-modulated-nanoliposomes-in-vitro-and-in-vivo-study
#2
COMPARATIVE STUDY
Heba F Salem, Sayed M Ahmed, Ashraf E Hassaballah, Mahmoud M Omar
BACKGROUND: The blood-brain barrier prevents many drug moieties from reaching the central nervous system. Therefore, glutathione-modulated nanoliposomes have been engineered to enhance the targeting of flucytosine to the brain. METHODS: Glutathione-modulated nanoliposomes were prepared by thin-film hydration technique and evaluated in the primary brain cells of rats. Lecithin, cholesterol, and span 65 were mixed at 1:1:1 molar ratio. The molar percentage of PEGylated glutathione varied from 0 mol% to 0...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/24020125/effects-of-supplementation-with-fish-oil-and-n-3-pufas-enriched-egg-yolk-phospholipids-on-anhedonic-like-response-and-body-weight-in-the-rat-chronic-mild-stress-model-of-depression
#3
M Rutkowska, M Trocha, M Szandruk, W Słupski, J Rymaszewska
Polyunsaturated fatty acids play an important role in the human organism. They guarantee a normal function of nervous cells, influence neurotransmission, and build some elements of cellular membranes. Several reports indicate an association between a deficiency of polyunsaturated fatty acids and depression. The aim of this study was to examine the effects of diet supplemented with fish oil, which is rich in omega-3 polyunsaturated fatty acids (n-3 PUFAs) and n-3 PUFAs enriched phospholipids ("super lecithin") obtained from designed eggs on anhedonic-like response and body weight in the rat chronic mild stress (CMS) model of depression...
August 2013: Die Pharmazie
https://www.readbyqxmd.com/read/23988655/loss-of-%C3%AE-carotene-15-15-oxygenase-in-developing-mouse-tissues-alters-esterification-of-retinol-cholesterol-and-diacylglycerols
#4
Joseph L Dixon, Youn-Kyung Kim, Anita Brinker, Loredana Quadro
We provide novel insights into the function(s) of β-carotene-15,15'-oxygenase (CMOI) during embryogenesis. By performing in vivo and in vitro experiments, we showed that CMOI influences not only lecithin:retinol acyltransferase but also acyl CoA:retinol acyltransferase reaction in the developing tissues at mid-gestation. In addition, LC/MS lipidomics analysis of the CMOI-/- embryos showed reduced levels of four phosphatidylcholine and three phosphatidylethanolamine acyl chain species, and of eight triacylglycerol species with four or more unsaturations and fifty-two or more carbons in the acyl chains...
January 2014: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/23378943/hypolipidemic-effect-of-methanol-fraction-of-aconitum-heterophyllum-wall-ex-royle-and-the-mechanism-of-action-in-diet-induced-obese-rats
#5
Arun Koorappally Subash, Anu Augustine
Aconitum heterophyllum is an endangered Himalayan plant included in "lekhaneyagana," a pharmacological classification mentioned by Charaka in "Charakasamhita" which means reduce excess fat. The subterranean part of the plant is used for the treatment of diseases like nervous system disorders, fever, diarrhea, obesity, etc. In the present study, we are reporting the hypolipidemic effect of methanol fraction of A. heterophyllum. The methanol extract of A. heterophyllum was orally administered in diet-induced obese rats...
October 2012: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/22117177/lecithin-chitosan-nanoparticles-for-transdermal-delivery-of-melatonin
#6
Anita Hafner, Jasmina Lovrić, Ivan Pepić, Jelena Filipović-Grčić
In this study, the potential of lecithin/chitosan nanoparticles (NPs) as colloidal nanosystem for transdermal melatonin delivery was investigated. Mean diameter and zeta-potential of NPs differing in lecithin type (Lipoid S45 and S100) and chitosan content ranged between 113.7 and 331.5 nm and 4.6 and 31.2 mV, respectively. Melatonin loadings were up to 7.2%. The potential of lecithin/chitosan NPs to enhance transdermal melatonin delivery was investigated by determining the drug flux across dermatomed porcine skin and its skin deposition...
2011: Journal of Microencapsulation
https://www.readbyqxmd.com/read/20496177/a-double-blind-placebo-controlled-trial-of-a-topical-treatment-for-chemotherapy-induced-peripheral-neuropathy-ncctg-trial-n06ca
#7
RANDOMIZED CONTROLLED TRIAL
Debra L Barton, Edward J Wos, Rui Qin, Bassam I Mattar, Nathan Benjamin Green, Keith S Lanier, James Dewitt Bearden, John W Kugler, Kay L Hoff, Pavan S Reddy, Kendrith M Rowland, Mike Riepl, Bradley Christensen, Charles L Loprinzi
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a troublesome chronic symptom that has no proven pharmacologic treatment. The purpose of this double-blind randomized placebo-controlled trial was to evaluate a novel compounded topical gel for this problem. METHODS: Patients with CIPN were randomized to baclofen 10 mg, amitriptyline HCL 40 mg, and ketamine 20 mg in a pluronic lecithin organogel (BAK-PLO) versus placebo (PLO) to determine its effect on numbness, tingling, pain, and function...
June 2011: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/18289004/pathways-of-acetylcholine-synthesis-transport-and-release-as-targets-for-treatment-of-adult-onset-cognitive-dysfunction
#8
REVIEW
F Amenta, S K Tayebati
Acetylcholine (ACh) is a neurotransmitter widely diffused in central, peripheral, autonomic and enteric nervous system. This paper has reviewed the main mechanisms of ACh synthesis, storage, and release. Presynaptic choline transport supports ACh production and release, and cholinergic terminals express a unique transporter critical for neurotransmitter release. Neurons cannot synthesize choline, which is ultimately derived from the diet and is delivered through the blood stream. ACh released from cholinergic synapses is hydrolyzed by acetylcholinesterase into choline and acetyl coenzyme A and almost 50% of choline derived from ACh hydrolysis is recovered by a high-affinity choline transporter...
2008: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/16579395/effect-of-ascorbic-acid-alpha-tocopherol-lecithin-and-l-ornithine-l-aspartate-on-ethanol-induced-hypoproteinemia-and-hyperlipidemia-in-rats
#9
M Maneesh, H Jayalekshmi
We studied effect of exogenous ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on serum lipids and proteins in experimental hepatotoxic Wistar rats. Eleven groups (n = 6) of animals were used. Hepatotoxicity was induced by administering ethanol (1.6 g/kg/day) for 28 days. Both preventive and curative options were studied. Percentage increase in body weight was significantly lower in ethanol treated rats. Ethanol significantly (P<0.05) increased cholesterol, triglycerides and LDL, and decreased protein, albumin and A:G ratio in serum...
October 2005: Indian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/16200721/-curative-effect-of-soybean-lecithin-on-cerebral-infarction
#10
F Shi, J Zhou, D Meng
OBJECTIVE: To investigate the clinical curative effect of soybean lecithin on cerebral infarction. METHODS: 542 patients with cerebral infarction within 48 h after the onset with the nervous function defect scores of 31-35 were divided into 3 groups: basic treatment group, 60 cases, with conventional treatment; citicoline group, 122 patients, with conventional treatment and citicoline; and soybean lecithin group, 360 patients, with conventional treatment and soybean lecithin 10 g tid...
November 10, 2001: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/15707984/lecithinized-brain-derived-neurotrophic-factor-promotes-the-differentiation-of-embryonic-stem-cells-in-vitro-and-in-vivo
#11
Aki Kitagawa, Toshiaki Nakayama, Mitsuko Takenaga, Kayo Matsumoto, Yukie Tokura, Yuki Ohta, Manabu Ichinohe, Yoko Yamaguchi, Noboru Suzuki, Hideyuki Okano, Rie Igarashi
The addition of lecithin molecules to brain-derived neurotrophic factor (BDNF) has been reported to markedly enhance its pharmacological effect in vivo. In the current study, we show that lecithinized BDNF (PC-BDNF) has a higher affinity than BDNF for neural precursor cells. Although BDNF only slightly increased the expression of the genes for Mash-1, p35, 68 kDa neurofilament, and TrkB receptor, PC-BDNF caused a significant increase in their expression. PC-BDNF also increased the level of neurofilament protein and dramatically increased TrkB mRNA gene expression, which was followed by a sustained activation of the p42/p44 extracellular-regulated kinases...
March 25, 2005: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/15653164/brain-derived-neurotrophic-factor-bound-with-lecithin-derivative-showed-a-markedly-enhanced-pharmacological-potency-due-to-its-potent-cell-membrane-affinity-followed-by-prolonged-mapk-activation
#12
Rie Igarashi, Toshiaki Nakayama, Mitsuko Takenaga, Manabu Ichinohe, Yoko Yamaguchi, Kayo Matsumoto, Aki Kitagawa, Natsumi Nakamura, Shinichi Kawai, Tsutomu Nakagawa, Mutsuo Taiji, Chikao Nakayama, Yutaka Mizushima
We synthesized lecithinized brain-derived neurotrophic factor (lecithinized-BDNF), in which an average of three molecules of a lecithin derivative were bound to recombinant human BDNF. We evaluated its pharmacological activity in C57BL/KsJ-db/db mice, and assessed its targetability and affinity for the nervous system. Subcutaneously administered lecithinized-BDNF markedly reduced the plasma glucose level, food intake, and body weight in C57BL/KsJ-db/db diabetic mice. Its potency was more than 20 times greater than that of unmodified BDNF...
February 2, 2005: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/15649651/elevation-of-superoxide-dismutase-increases-acoustic-trauma-from-noise-exposure
#13
Tsuyoshi Endo, Takayuki Nakagawa, Fukuichiro Iguchi, Tomoko Kita, Takayuki Okano, Su-Hua Sha, Jochen Schacht, Atsushi Shiga, Tae-Soo Kim, Juichi Ito
The generation of superoxide has been implicated as a cause of cochlear damage from excessive noise. Cu/Zn superoxide dismutase (SOD1) generally will protect against superoxide-mediated tissue injury but protection by this enzyme against noise trauma is controversial. This study assessed auditory function in C57BL/6 mice overexpressing SOD1 or treated with lecithinized SOD1 (PC-SOD1). Noise exposure caused significantly higher threshold shifts in PC-SOD1-treated animals than physiological saline-treated animals...
February 15, 2005: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/15253653/electrochemical-investigation-of-dopamine-at-the-water-1-2-dichloroethane-interface
#14
Dongping Zhan, Shuneng Mao, Qiang Zhao, Zhong Chen, Hu Hu, Ping Jing, Meiqin Zhang, Zhiwei Zhu, Yuanhua Shao
Dopamine is an important neurotransmitter in mammalian central and peripheral nervous systems and is also a medicament to cure some neuropsychosis. In this work, ion transfer (IT), facilitated ion transfer (FIT) of protonated dopamine, and electron transfer (ET) between dopamine and ferrocene are investigated at the water/1,2-dichloroethane (W/DCE) interface. The IT and FIT reactions of protonated dopamine can be observed simultaneously within the same potential window. The experimental results demonstrate that dibenzo-18-crown-6, dibenzo-24-crown-8, and benzo-15-crown-5 work well with the protonated dopamine...
July 15, 2004: Analytical Chemistry
https://www.readbyqxmd.com/read/14666245/neuroprotection-by-flavonoids
#15
REVIEW
F Dajas, F Rivera-Megret, F Blasina, F Arredondo, J A Abin-Carriquiry, G Costa, C Echeverry, L Lafon, H Heizen, M Ferreira, A Morquio
The high morbidity, high socioeconomic costs and lack of specific treatments are key factors that define the relevance of brain pathology for human health and the importance of research on neuronal protective agents. Epidemiological studies have shown beneficial effects of flavonoids on arteriosclerosis-related pathology in general and neurodegeneration in particular. Flavonoids can protect the brain by their ability to modulate intracellular signals promoting cellular survival. Quercetin and structurally related flavonoids (myricetin, fisetin, luteolin) showed a marked cytoprotective capacity in in vitro experimental conditions in models of predominantly apoptotic death such as that induced by medium concentrations (200 M) of H2O2 added to PC12 cells in culture...
December 2003: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/13840562/-changes-in-the-total-cholesterol-and-lipoid-phosphorus-lecithin-in-patients-with-arteriosclerosis-and-hypertension-in-connection-with-the-functional-state-of-the-nervous-system
#16
V T UVERSKAIA
No abstract text is available yet for this article.
1959: Trudy Leningradskogo Sanitarno-gigienicheskogo Meditsinskogo Instituta
https://www.readbyqxmd.com/read/12948002/role-of-infant-dietary-long-chain-polyunsaturated-fatty-acids-liposoluble-vitamins-cholesterol-and-lecithin-on-psychomotor-development
#17
REVIEW
F Cockburn
No abstract text is available yet for this article.
August 2003: Acta Paediatrica. Supplement
https://www.readbyqxmd.com/read/12589967/plasma-concentrations-of-lpl-and-lcat-are-in-putative-association-with-females-and-alcohol-use-which-are-independent-negative-risk-factors-for-coronary-atherosclerosis-among-japanese
#18
Akitomo Goto, Kanna Sasai, Shogo Suzuki, Tatsuya Fukutomi, Shigenori Ito, Toyoaki Matsushita, Mitsuhiro Okamoto, Takahiko Suzuki, Makoto Itoh, Kuniko Okumura-Noji, Shinji Yokoyama
BACKGROUND: Coronary heart disease (CHD) prevalence appears low among Japanese. Analysis of their negative risk factors is therefore important for public health strategy. METHODS: We analyzed the impact on coronary atherosclerosis of sex, alcohol intake, plasma lipoproteins and enzymes to regulate cholesterol transport, lipoprotein lipase (LPL) and lecithin:cholesterol acyltransferase (LCAT) for the 110 patients who underwent coronary angiography, consecutively enrolled by excluding those >70 years or under hypolipidemic-drug treatment...
March 2003: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/12077476/discernment-of-adipose-versus-nervous-tissue-a-novel-adjunct-solution-in-lipomyelomeningocele-surgery
#19
COMPARATIVE STUDY
Ravish V Patwardhan, R Shane Tubbs, Robert J Leonard, David Kelly, Cheryl R Killingsworth, Dennis L Rollins, William M Smith, Raymond E Ideker, W Jerry Oakes
OBJECTIVE: To determine a solution capable of discerning adipose versus nervous tissue, to aid in surgical separation of the adipose tissue which appears to be visually indistinguishable from nervous tissue in lipomyelomeningoceles (LMMs). METHODS: The following solutes (in normal saline) were investigated, both at 25 and 37 degrees C: beta-carotene, vitamin D, vitamin E, lecithin, hydrogen peroxide, lipase, protease, hyaluronidase, partially purified collagenase, purified collagenase, trypsin, trypsin plus purified collagenase and non-solute-containing saline (control)...
June 2002: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/11590208/sources-of-eicosanoid-precursor-fatty-acid-pools-in-tissues
#20
REVIEW
L Zhou, A Nilsson
Tissue arachidonic acid (AA) pools originate from the diet, and from hepatic and extrahepatic desaturation-elongation of dietary linoleic acid (LA). This review summarizes the roles of absorption, transport, and formation of AA in the buildup of tissue AA pools. In humans who ingest 0.2-0.3 g of AA and 10-20 g of LA per day on a Western diet, the formation of AA from LA exceeds the dietary supply of AA. A number of factors favor the partitioning of AA to tissue phospholipids rather than adipose tissue and plasma triglycerides...
October 2001: Journal of Lipid Research
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