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https://www.readbyqxmd.com/read/28743150/-anesthesiology-and-outcome-impact-of-the-perioperative-process
#1
Jörg Zieger, Helene A Häberle
In recent years, the role of the anesthesiologist has turned tremendously from the "anaesthesia doctor" into a perioperative physician and risk specialist. Patients are older, multimorbid, and are called up for more and more extensive surgery and interventions. Socioeconomic aspects have grown in importance. The anesthesiologist, paving the way for a good outcome, is involved in nearly all perioperative processes: preoperative evaluation, definition and optimization of preoperative and intraoperative conditions, management of modern intraoperative anesthesia as well as postoperative medically indicated, effective and efficient treatment of partially highly complex patients...
July 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28742762/kdigo-clinical-practice-guideline-on-the-evaluation-and-care-of-living-kidney-donors
#2
Krista L Lentine, Bertram L Kasiske, Andrew S Levey, Patricia L Adams, Josefina Alberú, Mohamed A Bakr, Lorenzo Gallon, Catherine A Garvey, Sandeep Guleria, Philip Kam-Tao Li, Dorry L Segev, Sandra J Taler, Kazunari Tanabe, Linda Wright, Martin G Zeier, Michael Cheung, Amit X Garg
The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors is intended to assist medical professionals who evaluate living kidney donor candidates and provide care before, during and after donation. The guideline development process followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach and guideline recommendations are based on systematic reviews of relevant studies that included critical appraisal of the quality of the evidence and the strength of recommendations...
August 2017: Transplantation
https://www.readbyqxmd.com/read/28742622/rational-therapeutic-choice-for-older-patients-with-lymphoma
#3
Dominique Bron, Pierre Soubeyran
PURPOSE OF REVIEW: The choice for an optimal treatment in older lymphoma patients is a real challenge for hemato-oncologists. They have to treat a potentially curative lymphoma, and concomitantly protect their patients from unacceptable toxicities. Some recommendations are provided for the major subtypes of lymphomas including the antitumoral treatment and primarily the optimal supportive care. RECENT FINDINGS: All the recent literature data converge to say that the approach of an older patient with a malignant hemopathy is a multistep procedure...
July 22, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28742321/understanding-the-effect-of-functional-groups-on-the-seeded-growth-of-copper-on-carbon-nanotubes-for-optimizing-electrical-transmission
#4
Kourtney Wright, Cathren E Gowenlock, Joseph Charles Bear, Andrew R Barron
We present a study of the seeded growth of copper on the surface of two classes of single-walled carbon nanotubes (SWNTs) in order to compare the effects of surface functional groups. Pyridine functionalized HiPco SWNTs and ultra-short SWNTs (US-SWNTs) were synthesized (py-SWNTs and py-US-SWNTs, respectively) and the functionality used as seed sites for copper, via an aqueous electroless deposition reaction, as a comparison to carboxylic acid functionality present on piranha etched SWNTs and the native US-SWNTs...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28742270/malignancy-screening-in-autoimmune-myositis-amongst-australian-rheumatologists
#5
Katherine Dutton, Muriel Soden
BACKGROUND: The international literature advocates for cancer screening in newly diagnosed patients with autoimmune myositis; however there is no widely-accepted consensus or guideline to outline the optimal cancer screening strategy and the evidence is currently insufficient to support any recommendation. AIMS: Our study aimed to establish the current trends in practice in malignancy screening in autoimmune myositis amongst Australian Rheumatologists. METHODS: All Rheumatologists who were full members of the Australian Rheumatology Association in 2016 (386) were invited to complete an online questionnaire...
July 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28742052/a-semi-analytical-model-of-time-reversal-cavity-for-high-amplitude-focused-ultrasound-applications
#6
Justine Robin, Mickael Tanter, Mathieu Pernot
Time reversal cavities (TRC) have been proposed as an efficient approach for 3D ultrasound therapy. They indeed allow precise spatio-temporal focusing of high power ultrasound pulses within a large region of interest with a low number of transducers. Leaky TRCs are usually built by placing a multiple scattering medium such as a random rods forest in a reverberating cavity, and the final peak pressure gain of the device only depends on the temporal length of its impulse response. Such multiple scattering in a reverberating cavity is a complex phenomenon, and the optimization of the device's gain is usually a cumbersome process, mostly empirical, and requiring numerical simulations with extremely long computational times...
July 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28742040/an-hp-adaptive-discretization-algorithm-for-signed-distance-field-generation
#7
Dan Koschier, Crispin Deul, Magnus Brand, Jan Bender
In this paper we present an hp-adaptive algorithm to generate discrete higher-order polynomial Signed Distance Fields (SDFs) on axis-aligned hexahedral grids from manifold polygonal input meshes. Using an orthonormal polynomial basis, we efficiently fit the polynomials to the underlying signed distance function on each cell. The proposed error-driven construction algorithm is globally adaptive and iteratively refines the SDFs using either spatial subdivision ( h-refinement) following an octree scheme or by cell-wise adaption of the polynomial approximation's degree ( p-refinement)...
July 21, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28741758/stem-cell-derived-exosomes-a-promising-strategy-for-fracture-healing
#8
REVIEW
Zi-Chen Hao, Jun Lu, Shan-Zheng Wang, Hao Wu, Yun-Tong Zhang, Shuo-Gui Xu
OBJECTIVES: To describe the biological characteristics of exosomes and to summarize the current status of stem cell-derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed. METHODS: Search and analyze the related articles in pubmed database through the multi-combination of keywords like "stem cells","exosomes","bone regeneration" and "fracture healing". CONCLUSION: Stem cell-derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention...
July 25, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28741739/reversible-fast-and-wide-range-oxygen-sensor-based-on-nanostructured-organometal-halide-perovskite
#9
Marc-Antoine Stoeckel, Marco Gobbi, Sara Bonacchi, Fabiola Liscio, Laura Ferlauto, Emanuele Orgiu, Paolo Samorì
Nanostructured materials characterized by high surface-volume ratio hold the promise to constitute the active materials for next-generation sensors. Solution-processed hybrid organohalide perovskites, which have been extensively used in the last few years for optoelectronic applications, are characterized by a self-assembled nanostructured morphology, which makes them an ideal candidate for gas sensing. Hitherto, detailed studies of the dependence of their electrical characteristics on the environmental atmosphere have not been performed, and even the effect of a ubiquitous gas such as O2 has been widely overlooked...
July 25, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28741461/the-enzymatic-degradation-of-heparan-sulfate
#10
Laura Griffin, Tracey Gloster
Glycosaminoglycans (GAGs) such as heparan sulfate (HS) interact with a number of factors in the extracellular matrix (ECM) and as a consequence play a key role in the metabolic processes occurring within the cell. The dynamic synthesis and degradation of HS (and all GAGs) are necessary for ensuring that optimal chains are present for these functions. The degradation of HS begins at the cell surface and finishes in the lysosome, after which components can be recycled. Deficiencies or mutations in the lysosomal enzymes that process GAGs result in rare Mucopolysaccharidoses disorders (MPSs)...
July 24, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28741107/development-and-optimization-of-a-novel-sample-preparation-method-cored-on-functionalized-nanofibers-mat-solid-phase-extraction-for-the-simultaneous-efficient-extraction-of-illegal-anionic-and-cationic-dyes-in-foods
#11
Feifei Qi, Ningge Jian, Liangliang Qian, Weixin Cao, Qian Xu, Jian Li
A simple and efficient three-step sample preparation method was developed and optimized for the simultaneous analysis of illegal anionic and cationic dyes (acid orange 7, metanil yellow, auramine-O, and chrysoidine) in food samples. A novel solid-phase extraction (SPE) procedure based on nanofibers mat (NFsM) was proposed after solvent extraction and freeze-salting out purification. The preferred SPE sorbent was selected from five functionalized NFsMs by orthogonal experimental design, and the optimization of SPE parameters was achieved through response surface methodology (RSM) based on the Box-Behnken design (BBD)...
July 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28740753/a-laid-back-trip-through-the-hennigian-forests
#12
Evgeny V Mavrodiev, Christopher Dell, Laura Schroder
BACKGROUND: This paper is a comment on the idea of matrix-free Cladistics. Demonstration of this idea's efficiency is a major goal of the study. Within the proposed framework, the ordinary (phenetic) matrix is necessary only as "source" of Hennigian trees, not as a primary subject of the analysis. Switching from the matrix-based thinking to the matrix-free Cladistic approach clearly reveals that optimizations of the character-state changes are related not to the real processes, but to the form of the data representation...
2017: PeerJ
https://www.readbyqxmd.com/read/28740720/analysing-the-reasons-of-failure-of-surgical-mitral-repair-approaches-do-we-need-to-better-think-in-biomechanics
#13
Massimiliano Fraldi, Cristiano Spadaccio, Christos G Mihos, Francesco Nappi
The failure of mitral valve repair procedures revealed in the outcomes of the recent randomized studies is suggesting the necessity for a better understanding of the biomechanical mechanisms underlying the failure of the surgical approaches. Use of biomechanical modelling and finite element analysis (FEA) in cardiovascular research is an important aid in this context. In our group we developed a biomechanical model taking into account all the component of the mitral valve functional unit including the valve leaflets, the annulus, the papillary muscles, the chordae tendinea and the ventricular geometry...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740487/determinants-of-bacterial-morphology-from-fundamentals-to-possibilities-for-antimicrobial-targeting
#14
REVIEW
Muriel C F van Teeseling, Miguel A de Pedro, Felipe Cava
Bacterial morphology is extremely diverse. Specific shapes are the consequence of adaptive pressures optimizing bacterial fitness. Shape affects critical biological functions, including nutrient acquisition, motility, dispersion, stress resistance and interactions with other organisms. Although the characteristic shape of a bacterial species remains unchanged for vast numbers of generations, periodical variations occur throughout the cell (division) and life cycles, and these variations can be influenced by environmental conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28740471/no-evidence-of-narrowly-defined-cognitive-penetrability-in-unambiguous-vision
#15
Nikki A Lammers, Edward H de Haan, Yair Pinto
The classical notion of cognitive impenetrability suggests that perceptual processing is an automatic modular system and not under conscious control. Near consensus is now emerging that this classical notion is untenable. However, as recently pointed out by Firestone and Scholl, this consensus is built on quicksand. In most studies claiming perception is cognitively penetrable, it remains unclear which actual process has been affected (perception, memory, imagery, input selection or judgment). In fact, the only available "proofs" for cognitive penetrability are proxies for perception, such as behavioral responses and neural correlates...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28739800/cell-free-production-of-a-functional-oligomeric-form-of-a-chlamydia-major-outer-membrane-protein-momp-for-vaccine-development
#16
Wei He, Martina Felderman, Angela C Evans, Jia Geng, David Homan, Feliza Bourguet, Nicholas O Fischer, Yuanpei Li, Kit S Lam, Aleksandr Noy, Li Xing, R Holland Cheng, Amy Rasley, Craig D Blanchette, Kurt Kamrud, Nathanial Wang, Heather Gouvis, Todd C Peterson, Bolyn Hubby, Matthew A Coleman
Chlamydia is a prevalent sexually transmitted disease that infects more than 100 million people worldwide. Although most individuals infected with Chlamydia trachomatis are initially asymptomatic, symptoms can arise if left undiagnosed. Long-term infection can result in debilitating conditions such as pelvic inflammatory disease, infertility, and blindness. Chlamydia infection, therefore, constitutes a significant public health threat, underscoring the need for a Chlamydia-specific vaccine. Chlamydia strains express a major outer-membrane protein (MOMP) that has been shown to be an effective vaccine antigen...
July 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28739651/improving-asthma-care-by-building-statewide-quality-improvement-infrastructure
#17
Judith C Dolins, Jennifer Powell, Edward Wise, Kimberly Giuliano, Peggy Stemmler, Wes Stubblefield, P Cooper White, James Wiley, Dennis Z Kuo
BACKGROUND AND OBJECTIVES: Pediatric medical professionals have an increasing desire for quality improvement (QI) methods that produce sustainable changes in health care delivery. Previous reports have described QI in single settings or single coordinating entities that work with multiple sites. The objectives of this project are (1) to improve care for children with asthma across multiple practice settings and (2) to develop state-level expertise to support QI projects across entities in multiple states...
July 24, 2017: Pediatrics
https://www.readbyqxmd.com/read/28739502/development-of-biomedical-5-fluorouracil-nanoplatforms-for-colon-cancer-chemotherapy-influence-of-process-and-formulation-parameters
#18
Elena Pretel, José L Arias, Laura Cabeza, Consolación Melguizo, José C Prados, Mireia Mallandrich, Joaquim Suñer, Beatriz Clares
In the present investigation solvent displacement or nanoprecipitation, and double emulsion/solvent evaporation methods were utilized to optimize poly(D,L-lactide-co-glycolide) nanoparticles for the vehiculization of the 5-fluorouracil. Formulation components from both the aqueous and organic phases, as well as, operating conditions were varied. Particles were characterized in terms of particle size and morphology, electrical properties, rheology, drug loading, stability, and drug release. Furthermore, in vitro cytotoxicity on human colon cells and different colon carcinoma cells was evaluated...
July 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28739275/evaluation-of-solvent-systems-for-optimized-extractables-studies-of-single-use-bioprocessing-solutions
#19
Noemí Dorival-García, Jonathan Bones
Despite their advantages, there is concern that single-use systems used in biopharmaceutical manufacture might release potentially toxic substances during standard unit operations that negatively impact cell growth. Characterization of the extractables profile for single-use systems is necessary to know which compounds potentially become leachables under operational cell culture conditions. A key issue in the design of extractables studies is the composition of the model solvent, in particular its pH and polarity...
June 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28739273/analysis-of-packing-microstructure-and-wall-effects-in-a-narrow-bore-ultrahigh-pressure-liquid-chromatography-column-using-focused-ion-beam-scanning-electron-microscopy
#20
Arved E Reising, Sabine Schlabach, Vasili Baranau, Daniela Stoeckel, Ulrich Tallarek
Column wall effects are well recognized as major limiting factor in achieving high separation efficiency in HPLC. This is especially important for modern analytical columns packed with small particles, where wall effects dominate the band broadening. Detailed knowledge about the packing microstructure of packed analytical columns has so far not been acquired. Here, we present the first three-dimensional reconstruction protocol for these columns utilizing focused ion-beam scanning electron microscopy (FIB-SEM) on a commercial 2...
July 14, 2017: Journal of Chromatography. A
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