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https://www.readbyqxmd.com/read/27933408/twelve-weeks-progressive-resistance-training-combined-with-protein-supplementation-beyond-habitual-intakes-increases-upper-leg-lean-tissue-mass-muscle-strength-and-extended-gait-speed-in-healthy-older-women
#1
Peter Francis, William Mc Cormack, Clodagh Toomey, Catherine Norton, Jean Saunders, Emmet Kerin, Mark Lyons, Philip Jakeman
The age-related decline in functional capability is preceded by a reduction in muscle quality. The purpose of this study was to assess the combined effects of progressive resistance training (PRT) and protein supplementation beyond habitual intakes on upper leg lean tissue mass (LTM), muscle quality and functional capability in healthy 50-70 years women. In a single-blinded, randomized, controlled design, 57 healthy older women (age 61.1 ± 5.1 years, 1.61 ± 0.65 m, 65.3 ± 15.3 kg) consumed 0.33 g/kg body mass of a milk-based protein matrix (PRO) for 12 weeks...
December 8, 2016: Biogerontology
https://www.readbyqxmd.com/read/27933257/assessment-of-the-quality-of-groundwater-for-drinking-purposes-in-the-upper-west-and-northern-regions-of-ghana
#2
Sixtus Bieranye Bayaa Martin Saana, Samuel Asiedu Fosu, Godfred Etsey Sebiawu, Napoleon Jackson, Thomas Karikari
BACKGROUND: Underground water is an important natural resource serving as a reliable source of drinking water for many people worldwide, especially in developing countries. Underground water quality needs to be given a primary research and quality control attention due to possible contamination. This study was therefore designed to determine the physico-chemical and bacteriological quality of borehole water in the Upper West and Northern regions of Ghana. METHODS: The study was conducted in seven districts in Ghana (including six in the Upper West region and one in the Northern region)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933211/systematic-review-and-quality-analysis-of-emerging-diagnostic-measures-for-calcium-pyrophosphate-crystal-deposition-disease
#3
Y Wu, K Chen, R Terkeltaub
OBJECTIVES: Calcium pyrophosphate crystal deposition disease (CPPD) is common, yet prevalence and overall clinical impact remain unclear. Sensitivity and specificity of CPPD reference standards (conventional crystal analysis (CCA) and radiography (CR)) were meta-analysed by EULAR (published 2011). Since then, new diagnostic modalities are emerging. Hence, we updated 2009-2016 literature findings by systematic review and evidence grading, and assessed unmet needs. METHODS: We performed systematic search of full papers (PubMed, Scopus/EMBASE, Cochrane 2009-2016 databases)...
2016: RMD Open
https://www.readbyqxmd.com/read/27933038/computing-and-applying-atomic-regulons-to-understand-gene-expression-and-regulation
#4
José P Faria, James J Davis, Janaka N Edirisinghe, Ronald C Taylor, Pamela Weisenhorn, Robert D Olson, Rick L Stevens, Miguel Rocha, Isabel Rocha, Aaron A Best, Matthew DeJongh, Nathan L Tintle, Bruce Parrello, Ross Overbeek, Christopher S Henry
Understanding gene function and regulation is essential for the interpretation, prediction, and ultimate design of cell responses to changes in the environment. An important step toward meeting the challenge of understanding gene function and regulation is the identification of sets of genes that are always co-expressed. These gene sets, Atomic Regulons (ARs), represent fundamental units of function within a cell and could be used to associate genes of unknown function with cellular processes and to enable rational genetic engineering of cellular systems...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27932865/statistical-modeling-methods-to-analyze-the-impacts-of-multiunit-process-variability-on-critical-quality-attributes-of-chinese-herbal-medicine-tablets
#5
Fei Sun, Bing Xu, Yi Zhang, Shengyun Dai, Chan Yang, Xianglong Cui, Xinyuan Shi, Yanjiang Qiao
The quality of Chinese herbal medicine tablets suffers from batch-to-batch variability due to a lack of manufacturing process understanding. In this paper, the Panax notoginseng saponins (PNS) immediate release tablet was taken as the research subject. By defining the dissolution of five active pharmaceutical ingredients and the tablet tensile strength as critical quality attributes (CQAs), influences of both the manipulated process parameters introduced by an orthogonal experiment design and the intermediate granules' properties on the CQAs were fully investigated by different chemometric methods, such as the partial least squares, the orthogonal projection to latent structures, and the multiblock partial least squares (MBPLS)...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27932595/the-relationship-between-acute-malnutrition-hygiene-practices-water-and-livestock-and-their-program-implications-in-eastern-chad
#6
Anastasia Marshak, Helen Young, Elizabeth N Bontrager, Erin M Boyd
BACKGROUND: The causes of acute malnutrition are complex and time and geography variant and need to be better understood in order to both design more effective nutrition programs and evaluate them. The findings reported here are part of an evaluation of a 4-year multisectoral nutrition program led by Concern Worldwide in the Sila Region of eastern Chad. OBJECTIVE: To present evidence and learning about the relationships between acute malnutrition and potential drivers in Sila, Chad...
December 8, 2016: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/27932546/what-can-a-participatory-approach-to-evaluation-contribute-to-the-field-of-integrated-care
#7
Laura Eyre, Michael Farrelly, Martin Marshall
Better integration of care within the health sector and between health and social care is seen in many countries as an essential way of addressing the enduring problems of dwindling resources, changing demographics and unacceptable variation in quality of care. Current research evidence about the effectiveness of integration efforts supports neither the enthusiasm of those promoting and designing integrated care programmes nor the growing efforts of practitioners attempting to integrate care on the ground. In this paper we present a methodological approach, based on the principles of participatory research, that attempts to address this challenge...
December 8, 2016: BMJ Quality & Safety
https://www.readbyqxmd.com/read/27932513/improving-incidence-of-postoperative-atrial-fibrillation-after-cardiac-surgery-using-simplified-clinical-practice-guidelines
#8
Amr S Omar, Hesham Ewila, Mahmoud Allam, Sameh Aboulnagah, Samy Hanoura, Praveen C Sivadasan, Ousama Bilal, Abdul Rasheed A Pattath, Abdulaziz AlKhulaifi
OBJECTIVES: Postoperative atrial fibrillation (POAF) remains a major risk after cardiac surgery. Twelve percent patients admitted to this unit postcardiac surgery experienced POAF, which led to hemodynamic instability, increased risk of stroke, and increased length of postoperative intensive care unit stay. Our aim was to decrease the incidence of POAF in the cardiothoracic intensive care unit by the end of April 2014. METHODS: Design-Retrospective data analysis...
December 8, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/27932337/development-of-a-critical-appraisal-tool-to-assess-the-quality-of-cross-sectional-studies-axis
#9
Martin J Downes, Marnie L Brennan, Hywel C Williams, Rachel S Dean
OBJECTIVES: The aim of this study was to develop a critical appraisal (CA) tool that addressed study design and reporting quality as well as the risk of bias in cross-sectional studies (CSSs). In addition, the aim was to produce a help document to guide the non-expert user through the tool. DESIGN: An initial scoping review of the published literature and key epidemiological texts was undertaken prior to the formation of a Delphi panel to establish key components for a CA tool for CSSs...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932315/design-and-testing-of-the-safety-agenda-mobile-app-for-managing-health-care-managers-patient-safety-responsibilities
#10
José Joaquín Mira, Irene Carrillo, Cesar Fernandez, Maria Asuncion Vicente, Mercedes Guilabert
BACKGROUND: Adverse events are a reality in clinical practice. Reducing the prevalence of preventable adverse events by stemming their causes requires health managers' engagement. OBJECTIVE: The objective of our study was to develop an app for mobile phones and tablets that would provide managers with an overview of their responsibilities in matters of patient safety and would help them manage interventions that are expected to be carried out throughout the year...
December 8, 2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27932265/ottawa-panel-evidence-based-clinical-practice-guidelines-for-structured-physical-activity-in-the-management-of-juvenile-idiopathic-arthritis
#11
REVIEW
Sabrina Cavallo, Lucie Brosseau, Karine Toupin-April, George A Wells, Christine A M Smith, Arlanna G Pugh, Jennifer Stinson, Roanne Thomas, Sara Ahmed, Ciarán M Duffy, Prinon Rahman, Inmaculada C Àlvarez-Gallardo, Laurianne Loew, Gino De Angelis, Debbie Ehrmann Feldman, Annette Majnemer, Isabelle J Gagnon, Désirée Maltais, Marie-Ève Mathieu, Glen P Kenny, Susan Tupper, Kristi Whitney-Mahoney, Sarah Bigford
OBJECTIVE: To create guidelines focused on the use of structured physical activity (PA) in the management of juvenile idiopathic arthritis (JIA). DATA SOURCES: A systematic literature search was conducted using the electronic databases Cochrane Central Register of Controlled Trials, Medline (Ovid), EMBASE (Ovid), and Physiotherapy Evidence Database (PEDro) for all studies related to PA programs for JIA from January 1966 until December 2014, and was updated in May 2015...
December 5, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27931592/the-rationale-for-performance-of-coronary%C3%A2-angiography-and-stenting-before-transcatheter-aortic-valve-replacement-from-the-interventional-section-leadership-council-of-the-american-college-of-cardiology
#12
REVIEW
Stephen Ramee, Saif Anwaruddin, Gautam Kumar, Robert N Piana, Vasilis Babaliaros, Tanveer Rab, Lloyd W Klein
Transcatheter aortic valve replacement (TAVR) is an effective, nonsurgical treatment option for patients with severe aortic stenosis. The optimal treatment strategy for treating concomitant coronary artery disease (CAD) has not been tested prospectively in a randomized clinical trial. Nevertheless, it is standard practice in the United States to perform coronary angiography and percutaneous coronary intervention for significant CAD at least 1 month before TAVR. All existing clinical trials were designed using this strategy...
December 12, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27931466/evidence-based-clinical-practice-guideline-for-the-use-of-pit-and-fissure-sealants
#13
(no author information available yet)
BACKGROUND: This article presents evidence-based clinical recommendations for the use of pit-and-fissure sealants on the occlusal surfaces of primary and permanent molars in children and adolescents. A guideline panel convened by the American Dental Association (ADA) Council on Scientific Affairs and the American Academy of Pediatric Dentistry conducted a systematic review and formulated recommendations to address clinical questions in relation to the efficacy, retention, and potential side effects of sealants to prevent dental caries; their efficacy compared with fluoride varnishes; and a head-to-head comparison of the different types of sealant material used to prevent caries on pits-and-fissures of occlusal surfaces...
October 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/27931279/mp-azeflu-provides-rapid-and-effective-allergic-rhinitis-control-in-real-life-a-pan-european-study
#14
Ludger Klimek, Claus Bachert, Par Stjrne, Ralph Dollner, Petter Larsen, Peter Haahr, Ioana Agache, Glenis Scadding, David Price
BACKGROUND: The European Union has prioritized allergic rhinitis (AR) control. Contre les Maladies Chronique pour un Vieillissement Actif Allergic Rhinitis and its Impact on Asthma has endorsed the visual analog scale (VAS) as the AR control language and incorporated it into a new AR treatment algorithm. Concurrently, the Respiratory Effectiveness Group and the European Academy of Allergy and Clinical Immunology are striving to improve the quality of published real-life AR research. Our aim was to assess the effectiveness of MP-AzeFlu by using a VAS in a well-designed, real-life, pan-European study...
September 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27931254/feasibility-of-an-online-intervention-stak-d-to-promote-physical-activity-in-children-with-type-1-diabetes-protocol-for-a-randomised-controlled-trial
#15
Holly Blake, Helen Quirk, Paul Leighton, Tabitha Randell, James Greening, Boliang Guo, Cris Glazebrook
BACKGROUND: Regular physical activity has important health benefits for children with type 1 diabetes mellitus (T1DM), yet children and their parents face barriers to participation such as lack of self-efficacy or concerns around hypoglycaemia. Multimedia interventions are useful for educating children about their health and demonstrate potential to improve children's health-related self-efficacy, but few paediatric clinics offer web-based resources as part of routine care. The Steps to Active Kids with Diabetes (STAK-D) programme is an online intervention grounded in psychological theory (social cognitive theory) and informed by extensive preliminary research...
December 8, 2016: Trials
https://www.readbyqxmd.com/read/27929734/assessment-of-the-validity-and-reliability-of-a-questionnaire-on-knowledge-and-attitude-of-general-practitioners-about-andropause
#16
Maliheh Abootalebi, Marzieh Kargar, Alireza Aminsharifi
BACKGROUND AND OBJECTIVE: Andropause is one of the clinical and biochemical syndromes in aging men associated with the decrease in serum testosterone levels. With the increase in aging male population, life span in Iran, and focus on quality of life, andropause will become a major health issue that needs to be addressed in order to prevent disability. General practitioners, as the first level of health care providers, are in the best position to assess their knowledge and attitude about andropause period, so a structured instrument is necessary to assess them...
December 8, 2016: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/27929459/perturbations-of-circulating-mirnas-in-irritable-bowel-syndrome-detected-using-a-multiplexed-high-throughput-gene-expression-platform
#17
Nicolaas H Fourie, Ralph M Peace, Sarah K Abey, LeeAnne B Sherwin, John W Wiley, Wendy A Henderson
The gene expression platform assay allows for robust and highly reproducible quantification of the expression of up to 800 transcripts (mRNA or miRNAs) in a single reaction. The miRNA assay counts transcripts by directly imaging and digitally counting miRNA molecules that are labeled with color-coded fluorescent barcoded probe sets (a reporter probe and a capture probe). Barcodes are hybridized directly to mature miRNAs that have been elongated by ligating a unique oligonucleotide tag (miRtag) to the 3' end...
November 30, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27928870/balance-evaluation-in-haemophilic-preadolescent-patients-using-nintendo-wii-balance-board-%C3%A2
#18
S Pérez-Alenda, J J Carrasco, M Aguilar-Rodríguez, L Martínez-Gómez, M Querol-Giner, R Cuesta-Barriuso, A Torres-Ortuño, F Querol
INTRODUCTION: Alterations in the musculoskeletal system, especially in the lower limbs, limit physical activity and affect balance and walking. Postural impairments in haemophilic preteens could increase the risk of bleeding events and deteriorate the physical condition, promoting the progression of haemophilic arthropathy. AIM: This study aims to evaluate static postural balance in haemophilic children, assessed by means of the Wii Balance Board(®) (WBB). METHODS: Nineteen children with haemophilia and 19 without haemophilia aged 9-10 years, have participated in this study...
December 8, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27928859/mindfulness-interventions-for-psychosis-a-systematic-review-of-the-literature
#19
REVIEW
J Aust, T Bradshaw
: WHAT IS KNOWN ON THE SUBJECT?: Psychosis and the more specific diagnosis of schizophrenia constitute a major psychiatric disorder which impacts heavily on the self-esteem, functioning and quality of life of those affected. A number of mindfulness therapies have been developed in recent years, showing promising results when used with people with the disorder. WHAT THIS PAPER ADDS TO EXISTING KNOWLEDGE?: This review of the literature included only randomized controlled trials (RCTs), rather than other typically less robust methods of research (e...
December 8, 2016: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/27928857/further-examination-of-predictors-of-turnover-intention-among-mental-health-professionals
#20
N J Yanchus, D Periard, K Osatuke
: WHAT IS KNOWN ON THE SUBJECT?: When mental health professionals leave organizations, detrimental effects on quality of patient care occur. Reasons for leaving include incivility, lack of autonomy, perceptions of unfair treatment and feeling psychologically unsafe at work. This paper sought to investigate additional reasons why mental health professionals intend to quit or to cognitively withdraw from their jobs. WHAT DOES THIS PAPER ADD TO EXISTING KNOWLEDGE?: Past research on this topic is limited in its scope and data...
December 8, 2016: Journal of Psychiatric and Mental Health Nursing
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