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Tension normal glaucoma

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https://www.readbyqxmd.com/read/28435208/is-high-myopia-a-risk-factor-for-visual-field-progression-or-disk-hemorrhage-in-primary-open-angle-glaucoma
#1
Koji Nitta, Kazuhisa Sugiyama, Ryotaro Wajima, Gaku Tachibana
PURPOSE: The purpose of this study was to clarify differences between highly myopic and non-myopic primary open-angle glaucoma (POAG) patients, including normal-tension glaucoma patients. PATIENTS AND METHODS: A total of 269 POAG patients were divided into two groups: patients with ≥26.5 mm of axial length (highly myopic group) and patients with <24.0 mm of axial length (non-myopic group). RESULTS: We analyzed 53 highly myopic and 93 non-myopic POAG patients...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28429123/optical-coherence-tomography-angiography-vessel-density-mapping-at-various-retinal-layers-in-healthy-and-normal-tension-glaucoma-eyes
#2
Joong Won Shin, Kyung Rim Sung, Ji Yun Lee, Junki Kwon, Mincheol Seong
PURPOSE: To investigate peripapillary vessel density at various spatial locations and layers in healthy and normal tension glaucoma eyes using optical coherence tomography angiography (OCTA). METHODS: A commercial OCTA device (AngioPlex; Carl Zeiss Meditec) was used to image microvasculature in a 6 × 6-mm optic disc region. Vessel densities of superficial and deep retinal layers were calculated using an automatic thresholding algorithm. Vessel density maps were plotted by averaging individual angiogram images...
April 20, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28424747/association-between-optic-nerve-head-microcirculation-and-macular-ganglion-cell-complex-thickness-in-eyes-with-untreated-normal-tension-glaucoma-and-a-hemifield-defect
#3
Ayako Anraku, Kyoko Ishida, Nobuko Enomoto, Seiji Takagi, Hiroyuki Ito, Asuka Takeyama, Fumihiko Yagi, Goji Tomita
Purpose. We evaluated the association between optic nerve head (ONH) microcirculation and macular ganglion cell complex (mGCC) thickness in patients with untreated normal tension glaucoma (NTG) and a hemifield defect. Methods. The medical records of 47 patients with untreated NTG were retrospectively reviewed. Laser speckle flowgraphy was used to obtain mean blur rate (MBR), a relative measure of blood flow. Average total deviation (TD), mGCC, and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness were also analyzed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28416494/long-term-clinical-course-of-normotensive-preperimetric-glaucoma
#4
Akira Sawada, Yusuke Manabe, Tetsuya Yamamoto, Chisato Nagata
AIMS: To evaluate the long-term clinical course of normotensive preperimetric glaucoma (PPG). METHODS: We retrospectively analysed 130 eyes of 130 patients initially diagnosed as having preperimetric normal tension glaucoma and followed these cases for at least 5 years with reliable visual field (VF) examinations by standard automated perimetry. When the VF defect (VFD) met Anderson-Patella's criteria on three or more consecutive examinations, and consistently met the criteria on subsequent examinations, we concluded that a glaucomatous VFD was present...
April 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28374269/effect-of-glaucoma-implant-surgery-on-intraocular-pressure-reduction-flare-count-anterior-chamber-depth-and-corneal-endothelium-in-primary-open-angle-glaucoma
#5
Kyoko Ishida, Naoya Moroto, Kazuhiro Murata, Tetsuya Yamamoto
PURPOSE: To evaluate the effect of filtering surgery using the EX-PRESS device on intraocular pressure (IOP), flare count, anterior chamber (AC) depth, and the corneal endothelium in primary open-angle glaucoma (POAG), including normal-tension glaucoma (NTG). PATIENTS AND METHODS: The study comprised 63 consecutive patients with POAG or NTG. They underwent complete ophthalmologic examinations, including measurement of visual acuity (VA), IOP, flare count, AC depth, and cell density of the corneal endothelium (CE)...
April 3, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28348633/differentiating-leber-hereditary-optic-neuropathy-from-normal-tension-glaucoma
#6
Fernanda Maria Silveira Souto, José Paulo Cabral de Vasconcellos, Mônica Barbosa de Melo, Edi Lúcia Sartorato, Frederico Castelo Moura
Glaucoma is a neurodegenerative disorder characterized by thinning of neuroretinal rim, enlarged cup-to-disc ratio (CDR) and visual field damage. Although raised intraocular pressure is main risk factor for development of glaucoma, it can occur with consistently normal measurements in the intraocular pressure as normal tension glaucoma (NTG). Enlargement of CDR is a classical sign of glaucoma, but it can also result from non-glaucomatous optic neuropathies such as Leber hereditary optic neuropathy (LHON). We describe a case of LHON with increased CDR, discuss its differential diagnosis with NTG and highlight the reasons for misdiagnoses between these two entities...
April 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28333895/visual-field-defects-in-young-patients-with-open-angle-glaucoma-comparison-between-high-tension-and-normal-tension-glaucoma
#7
Ji-Hye Park, Chungkwon Yoo, Jinhwan Park, Yong Yeon Kim
PURPOSE: To investigate the clinical features of young Korean patients with open-angle glaucoma (OAG), and to compare visual field (VF) defects between patients with normal-tension glaucoma (NTG) and those with high-tension glaucoma (HTG). MATERIALS AND METHODS: Patients with OAG younger than 40 years of age were divided into NTG and HTG groups based on untreated intraocular pressure (IOP) level. The patients were matched according to the mean deviation of standard automated perimetry...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28315568/diurnal-blood-pressure-parameters-in-normal-tension-glaucoma-primary-open-angle-glaucoma-and-healthy-subjects
#8
Tolga Kocatürk, Çağdaş Akgüllü, Gökhan E Evliçoğlu, İmran K Ömürlü, Harun Çakmak, Ufuk Eryılmaz, Volkan Dayanır
OBJECTIVE: The pathophysiology of glaucoma is still undisclosed. Cardiovascular hemodynamic changes are hypothesized to contribute to glaucoma. This study aimed to determine the differences in the diurnal blood pressure (BP) of patients with normal tension glaucoma (NTG), primary open angle glaucoma (POAG), and controls without glaucoma. METHODS: A total of 129 patients were included in this study. The day-night average systolic and diastolic BPs, the day-night average pulse pressures (PPs), the day-night average heart rates, and the percentage of BP decline at night were obtained from the Holter devices and compared...
March 9, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28306361/visual-field-progression-is-associated-with-systemic-concentration-of-macrophage-chemoattractant-protein-1-in-normal-tension-glaucoma
#9
Na Young Lee, Min Hee Kim, Chan Kee Park
PURPOSE: To investigate the associations between endothelin-1 (ET-1) and macrophage chemoattractant protein-1 (MCP-1) levels and visual field (VF) progression in normal-tension glaucoma (NTG). METHODS: We conducted a prospective, longitudinal study in 71 patients with NTG. Blood samples from all subjects were assayed for ET-1 and MCP-1 concentrations, and baseline ophthalmic examinations, including the VF, were performed. Baseline data were compared with follow-up data over 3 years...
March 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28288589/choroidal-infarction-in-a-glaucoma-patient-with-flammer-syndrome-a-case-report-with-a-long-term-follow-up
#10
Barbara Terelak-Borys, Iwona Grabska-Liberek, Anita Piekarniak-Wozniak, Katarzyna Konieczka
BACKGROUND: We present a long term follow-up of a young female patient with choroidal infarction, primary open angle glaucoma and Flammer syndrome. The patient had no classical risk factors for vascular occlusions, except for the presence of Flammer syndrome. The essential feature of this syndrome is primary vascular dysregulation, sometimes including vasospasm. The vessels of affected people respond more intensely to a number of stimuli, such as coldness or emotional stress. Any organ can be involved, including parts of the eye...
March 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28285308/clinical-features-of-japanese-patients-with-central-retinal-vein-occlusion-complicated-by-normal-tension-glaucoma-a-retrospective-study
#11
Teruyo Kida, Masanori Fukumoto, Takaki Sato, Hidehiro Oku, Tsunehiko Ikeda
PURPOSE: The association of central retinal vein occlusion (CRVO) with primary open-angle glaucoma (POAG) or ocular hypertension has been reported, and lowering intraocular pressure (IOP) helps to improve the retinal circulation in eyes with CRVO. However, the clinical features of CRVOs with normal-tension glaucoma (NTG) are not well known. Therefore, we investigated Japanese CRVO patients with NTG. METHODS: We retrospectively investigated 234 CRVO patients over 5 years, with follow-ups of more than 12 months, and evaluated the prevalence of glaucoma...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28282064/predicting-the-risk-of-parafoveal-scotoma-in-myopic-normal-tension-glaucoma-role-of-optic-disc-tilt-and-rotation
#12
M S Sung, H Heo, Y S Ji, S W Park
PurposeThe purpose of the study was to evaluate the factors associated with development of parafoveal scotoma in early myopic normal tension glaucoma (NTG).Patients and methodsNinety-nine myopic NTG patients with mean deviation (MD) >-6.0 decibels (dB) were enrolled. Parafoveal scotoma was defined as a visual field (VF) defect within 10° of fixation with at least one point at P<1% lying at the four innermost central points. Systemic factors, optic disc characteristics including tilt ratio, rotation degree, β-zone parapapillary atrophy, disc hemorrhage, and peripapillary retinal nerve fiber layer and macular ganglion cell-inner plexiform layer (mGCIPL) thickness parameters using optical coherence tomography were evaluated...
March 10, 2017: Eye
https://www.readbyqxmd.com/read/28280945/influence-of-intraocular-pressure-reduction-on-progression-of-normal-tension-glaucoma-with-myopic-tilted-disc-and-associated-risk-factors
#13
Bo Ram Seol, Soa Kim, Dong Myung Kim, Ki Ho Park, Jin Wook Jeoung, Seok Hwan Kim
Purpose To evaluate the influence of intraocular pressure (IOP) reduction on progression of normal-tension glaucoma (NTG) with myopic tilted disc and to demonstrate the associated risk factors. METHODS: The medical records on 109 eyes of 109 NTG patients with myopic tilted discs who were followed up for more than 5 years and treated with topical medications were reviewed. Glaucoma progression was defined according to either structural or functional deterioration. Patients were divided into tertile groups according to the percent IOP reduction from the baseline, and the cumulative probability of NTG nonprogression of the upper- and lower-tertile groups was compared using Kaplan-Meier survival analysis...
March 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28280481/the-optic-canal-a-bottleneck-for-cerebrospinal-fluid-dynamics-in-normal-tension-glaucoma
#14
Achmed Pircher, Margherita Montali, Jatta Berberat, Luca Remonda, Hanspeter E Killer
PURPOSE: To report on the optic canal cross-sectional area (OCA) in Caucasian patients with normal-tension glaucoma (NTG) compared with Caucasian control subjects without known optic nerve (ON) diseases. METHODS: Retrospective analysis of computed tomographic images of the cranium and orbits in 56 NTG patients (30 females and 26 males; 99 of 112 eyes; mean age 67.7 ± 11.1 years). Fifty-six age- and gender-matched subjects (mean age: 68.0 ± 11.2 years) without known ON diseases served as controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28269436/development-of-ocular-viscosity-characterization-method
#15
Shu-Hao Lu, Guo-Zhen Chen, Stanley Y Y Leung, David C C Lam
Glaucoma is the second leading cause for blindness. Irreversible and progressive optic nerve damage results when the intraocular pressure (IOP) exceeds 21 mmHg. The elevated IOP is attributed to blocked fluid drainage from the eye. Methods to measure the IOP are widely available, but methods to measure the viscous response to blocked drainage has yet been developed. An indentation method to characterize the ocular flow is developed in this study. Analysis of the load-relaxation data from indentation tests on drainage-controlled porcine eyes showed that the blocked drainage is correlated with increases in ocular viscosity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264060/whole-exome-sequencing-implicates-eye-development-the-unfolded-protein-response-and-plasma-membrane-homeostasis-in-primary-open-angle-glaucoma
#16
Tiger Zhou, Emmanuelle Souzeau, Shiwani Sharma, John Landers, Richard Mills, Ivan Goldberg, Paul R Healey, Stuart Graham, Alex W Hewitt, David A Mackey, Anna Galanopoulos, Robert J Casson, Jonathan B Ruddle, Jonathan Ellis, Paul Leo, Matthew A Brown, Stuart MacGregor, David J Lynn, Kathryn P Burdon, Jamie E Craig
PURPOSE: To identify biological processes associated with POAG and its subtypes, high-tension (HTG) and normal-tension glaucoma (NTG), by analyzing rare potentially damaging genetic variants. METHODS: A total of 122 and 65 unrelated HTG and NTG participants, respectively, with early onset advanced POAG, 103 non-glaucoma controls and 993 unscreened ethnicity-matched controls were included in this study. Study participants without myocilin disease-causing variants and non-glaucoma controls were subjected to whole exome sequencing on an Illumina HiSeq2000...
2017: PloS One
https://www.readbyqxmd.com/read/28258400/a-review-of-selective-laser-trabeculoplasty-recent-findings-and-current-perspectives
#17
REVIEW
Yujia Zhou, Ahmad A Aref
Selective laser trabeculoplasty (SLT) has been widely used in the clinical management of glaucoma, both as primary and adjunctive treatment. As new evidence continues to arise, we review the current literature in terms of indications and efficacy, surgical technique, postoperative care, repeatability, and complications of this therapy. SLT has been shown to be effective in various glaucomas, including primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), steroid-induced glaucoma, pseudoexfoliation glaucoma (PXFG), and primary angle-closure glaucoma (PACG), as well as other glaucoma subtypes...
March 3, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28251307/-diffusion-tensor-imaging-of-the-visual-pathway-in-glaucomatous-optic-nerve-atrophy
#18
REVIEW
T Engelhorn, M A Schmidt, A Dörfler, G Michelson
In Germany more than one million inhabitants suffer from glaucoma, more than 100,000 are threatened with blindness because glaucoma is often diagnosed too late or not at all. Diagnosis and monitoring is usually carried out "only" by examination of the retina and not the whole visual pathway. However, the eye is just "the tip of the iceberg" of the actual visual pathway, which extends through the brain to the visual cortex. The interdisciplinary holistic assessment of the whole visual pathway in glaucoma is of crucial importance because glaucoma is a complex neurodegenerative disease...
March 1, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28243830/stage-of-visual-field-loss-and-age-at-diagnosis-in-1988-patients-with-different-glaucomas-implications-for-glaucoma-screening-and-driving-ability
#19
Gwendolyn Gramer, Eugen Gramer
PURPOSE: To compare stage of visual field loss (VFL) and age at diagnosis between patients with different types of glaucoma with regard to glaucoma screening and driving ability. METHODS: In a cross-sectional study of 1988 consecutive patients with different types of glaucoma VFL at diagnosis and age at diagnosis were assessed. Patients with binocular advanced or severe VFL were classified unable, patients with no VFL in one eye and VFL I-V (Aulhorn classification) in the other eye able, all other constellations questionably able to drive...
February 27, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28237136/risk-factors-for-visual-field-progression-of-normal-tension-glaucoma-in-patients-with-myopia
#20
Hyoung Won Bae, Sang Jin Seo, Sang Yeop Lee, Yun Ha Lee, Samin Hong, Gong Je Seong, Chan Yun Kim
OBJECTIVE: To identify risk factors for visual field progression of normal-tension glaucoma (NTG) in patients with myopia. DESIGN: Longitudinal, observational study. PARTICIPANTS: Fifty-one eyes of 51 NTG patients with myopia (less than -0.75D based on spherical equivalence) who had undergone visual field (VF) testing at least once per year for ≥6 years between November 2005 and December 2013. METHODS: Progression was defined using event-based guided progression analysis...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
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