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Tension normal glaucoma

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https://www.readbyqxmd.com/read/28703795/edaravone-suppresses-retinal-ganglion-cell-death-in-a-mouse-model-of-normal-tension-glaucoma
#1
Kei Akaiwa, Kazuhiko Namekata, Yuriko Azuchi, Xiaoli Guo, Atsuko Kimura, Chikako Harada, Yoshinori Mitamura, Takayuki Harada
Glaucoma, one of the leading causes of irreversible blindness, is characterized by progressive degeneration of optic nerves and retinal ganglion cells (RGCs). In the mammalian retina, excitatory amino-acid carrier 1 (EAAC1) is expressed in neural cells, including RGCs. Loss of EAAC1 leads to RGC degeneration without elevated intraocular pressure (IOP) and exhibits glaucomatous pathology including glutamate neurotoxicity and oxidative stress. In the present study, we found that edaravone, a free radical scavenger that is used for treatment of acute brain infarction and amyotrophic lateral sclerosis (ALS), reduces oxidative stress and prevents RGC death and thinning of the inner retinal layer in EAAC1-deficient (KO) mice...
July 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28683479/-diagnostic-precision-of-the-confocal-scanning-laser-ophthalmoscopy-in-the-large-optic-disc-with-physiological-excavation-a-long-term-study
#2
Eva Charlotte Koch, Niklas Plange, Matthias Fuest, Hannah Schimitzek, David Kuerten
We repeatedly examined 17 subjects with presumed bilateral physiological excavation labeled as pathological and/or borderline via HRT to verify the diagnosis of physiological cupping or to monitor the long-term progression into normal tension glaucoma. Patients and Methods 17 Subjects with presumed bilateral physiological cupping and large optic discs were included in this long-term follow-up study. All subjects underwent regular detailed ophthalmologic examinations, including intraocular pressure measurement via Goldmann applanation tonometry (GAT), retinal nerve fiber layer imaging via optical coherence tonometry (OCT) and visual field testing and optic disc imaging using the HRT...
July 6, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28667424/evaluating-retinal-vessel-diameter-with-optical-coherence-tomography-in-normal-tension-glaucoma-patients
#3
Takeshi Yabana, Yukihiro Shiga, Ryo Kawasaki, Kazuko Omodaka, Hidetoshi Takahashi, Koudai Kimura, Kyosuke Togashi, Takaaki Horii, Kei Sasaki, Testuya Yuasa, Toru Nakazawa
PURPOSE: To investigate a novel optical coherence tomography (OCT)-derived variable, circumpapillary mean retinal shadow width (cpMRSW), and to elucidate its association with normal-tension glaucoma (NTG). METHODS: For the purpose of validation, we measured retinal vascular calibers in 68 arterioles and 100 venules of 12 NTG patients and 12 healthy subjects and compared the width of the visible retinal shadows in spectral-domain OCT images and the caliber of retinal vessels in retinal photographs...
June 30, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28660081/analysis-of-peripapillary-retinal-vessel-diameter-in-unilateral-normal-tension-glaucoma
#4
Yong Un Shin, Sang Eon Lee, Heeyoon Cho, Min Ho Kang, Mincheol Seong
PURPOSE: This study sought to analyze peripapillary retinal vessel diameter and evaluate its correlation with retinal nerve fiber layer (RNFL) thickness in patients with unilateral normal-tension glaucoma (NTG). METHODS: This retrospective study included 37 patients with unilateral NTG and 40 healthy controls. The unilateral NTG patients were selected based on RNFL photography and unilateral visual field (VF) defects from the Humphrey central 30-2 threshold test...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28658128/association-of-wdr36-polymorphisms-with-primary-open-angle-glaucoma-a-systematic-review-and-meta-analysis
#5
REVIEW
Ke Liu, Wenling He, Jun Zhao, Yingxia Zeng, Hongbo Cheng
BACKGROUND: The association of the WDR36 gene with glaucoma has been controversial in the literature. We therefore conducted a systematic review and meta-analysis to assess the association of all reported common polymorphisms in WDR36 with primary open angle glaucoma (POAG) and its subtypes: high tension glaucoma (HTG) and normal tension glaucoma (NTG). METHODS: Publications in PUBMED and EMBASE databases up to March 9, 2016 were searched for case-control association studies of WDR36 with POAG, HTG, and/or NTG...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28635642/lack-of-association-between-serum-vitamin-b%C3%A2-vitamin-b12-and-vitamin-d-levels-with-different-types-of-glaucoma-a-systematic-review-and-meta-analysis
#6
Shengjie Li, Danhui Li, Mingxi Shao, Wenjun Cao, Xinghuai Sun
Although vitamins play a major role in health, and their deficiency may be linked to symptoms of optic-nerve dysfunction, the association between serum vitamin levels and glaucoma in humans remains controversial. In this study, articles in the PubMed, Web of Science, and EMBASE databases were searched up to 25March 2017. Nine studies on primary open-angle glaucoma (POAG), four studies on normal tension glaucoma (NTG), and six studies on exfoliative glaucoma (EXG) were retrieved. The combined results showed no differences in the levels of serum vitamin B₆ between POAG (p = 0...
June 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28628626/is-normal-tension-glaucoma-a-risk-factor-for-stroke-a-10-year-follow-up-study
#7
Meng-Sheng Lee, Li-Lin Kuo, Elise Chia-Hui Tan, Oscar K Lee
OBJECTIVES: To investigate whether patients with normal-tension glaucoma (NTG) have a higher incidence of stroke. DESIGN: A population-based retrospective cohort study based on data from the Taiwan National Health Insurance Research Database (NHIRD) from January 1, 2001, to December 31, 2010. METHODS: Data were retrospectively collected from the NHIRD. A total of 245 (20.1%) patients with a history of stroke at the time of glaucoma diagnosis were excluded, and 1,218 patients with NTG who were 20 years of age and older were identified...
2017: PloS One
https://www.readbyqxmd.com/read/28621876/social-health-and-ocular-factors-associated-with-primary-open-angle-glaucoma-amongst-chinese-singaporeans
#8
Nathalie Chiam, Mani Baskaran, Zheng Li, Shamira Perera, David Goh, Rahat Husain, Chiea Chuen Khor, Ching-Yu Cheng, Tin Aung FRCOphth, Eranga N Vithana
IMPORTANCE: There is limited literature on the association of lifestyle and health factors related to primary open angle glaucoma amongst Asians. BACKGROUND: This study evaluated the association of primary open angle glaucoma with smoking, health and ocular factors among Chinese Singaporeans. DESIGN: Case-control study PARTICIPANTS: 711 primary open angle glaucoma patients from a Singapore hospital and 2788 population-based controls. METHODS: Subjects underwent clinical examination and completed a questionnaire with details on family history of glaucoma, comorbidities, smoking, alcohol consumption, age at menopause and use of hormone replacement therapy...
June 16, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28571810/predictive-role-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-normal-tension-glaucoma
#9
Kursat Atalay, Havva Kaldirim Erdogan, Ahmet Kirgiz, Senay Asik Nacaroglu
As a type of primary open-angle glaucoma, normal-tension glaucoma (NTG) is a health problem that manifests itself with low intraocular pressure (IOP) levels and preserves its importance for public health care. In population-based screenings, which take the IOP levels of 21mmHg as a cut-off for the diagnosis of glaucoma, the diagnosis is usually delayed, and the treatment is started in an advanced stage by the referred ophthalmologists. NTG is associated with some autoimmune conditions and systemic diseases, such as paraproteinemia, nocturnal hypotension, and migraine...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28564702/associations-between-%C3%AE-peripapillary-atrophy-and-reticular-pseudodrusen-in-early-age-related-macular-degeneration
#10
Aakriti Garg, Dana M Blumberg, Lama A Al-Aswad, Maris Oll, Suzanne Yzer, Max Forbes, Rando L Allikmets, Srilaxmi Bearelly
Purpose: Choroidal thinning has been associated with reticular pseudodrusen (RPD) and β-peripapillary atrophy (β-PPA), which have been linked to normal-tension glaucoma (NTG). This analysis sought to determine whether RPD are independently associated with β-PPA in early AMD patients. Secondary outcomes included the association of RPD and preexisting diagnosis of glaucoma, cup-to-disc ratio (CDR), subfoveal choroidal thickness (SFCT), and IOP. Methods: This prospective cross-sectional study examined 78 age- and sex-matched early AMD patients: 43 RPD patients (63 eyes) and 35 non-RPD patients (64 eyes)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28550431/impact-of-intraocular-pressure-reduction-on-visual-field-progression-in-normal-tension-glaucoma-followed-up-over-15%C3%A2-years
#11
Shinya Oie, Kyoko Ishida, Tetsuya Yamamoto
PURPOSE: To investigate the impact of surgical or medical reduction of intraocular pressure (IOP) on progressive normal-tension glaucoma followed up over 15 years. METHODS: Sixty eyes of 60 patients were divided into 3 intervention groups: group 1 (trabeculectomy, n = 17); group 2 (IOP reduction rate ≥15% with prostaglandin analogs, n = 24); and group 3 (IOP reduction rate <15% with prostaglandin analogs, n = 19). The preintervention and postintervention mean deviation (MD) slopes and IOP were compared...
July 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28538978/the-characteristics-of-deep-optic-nerve-head-morphology-in-myopic-normal-tension-glaucoma
#12
Jong Chul Han, Eun Jung Lee, Si Bum Kim, Changwon Kee
Purpose: To investigate the relationship between axial length (AL) and deep optic nerve head (ONH) structure and to evaluate the characteristics of deep ONH structures in myopic normal tension glaucoma (NTG). Methods: The following parameters were assessed using spectral-domain optical coherence tomography (SD-OCT): externally oblique border tissue (EOBT) length, ONH tilt angle, optic canal (OC) obliqueness, and β-zone peripapillary atrophy (PPA). In addition, the angular location of the maximal value of each parameter and retinal nerve fiber layer (RNFL) defect were measured using infrared and red-free photos...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28508306/multicenter-randomized-investigator-masked-study-comparing-brimonidine-tartrate-0-1-and-timolol-maleate-0-5-as-adjunctive-therapies-to-prostaglandin-analogues-in-normal-tension-glaucoma
#13
Shiro Mizoue, Koji Nitta, Motohiro Shirakashi, Akiyoshi Nitta, Shigeki Yamabayashi, Tairo Kimura, Toshihiko Ueda, Ryuji Takeda, Shun Matsumoto, Keiji Yoshikawa
INTRODUCTION: This study compared the efficacy and safety of adjunctive brimonidine tartrate 0.1% ophthalmic solution (brimonidine) and timolol maleate 0.5% ophthalmic solution (timolol) in prostaglandin analogue (PGA)-treated normal-tension glaucoma (NTG), assessing the non-inferiority of brimonidine in terms of intraocular pressure (IOP) reduction. METHODS: In this multicenter, randomized, investigator-masked, parallel-group, clinical study, adjunctive brimonidine or timolol was administered twice daily for 12 weeks in eyes with NTG that had been treated with PGA for at least 90 days and required additional treatment despite an IOP of 16 mmHg or less...
May 15, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28505344/genetics-of-glaucoma
#14
Janey L Wiggs, Louis R Pasquale
Genetic and genomic studies, including genome-wide association studies (GWAS) have accelerated the discovery of genes contributing to glaucoma, the leading cause of irreversible blindness world-wide. Glaucoma can occur at all ages, with Mendelian inheritance typical for rare early onset disease (before age 40) and complex inheritance evident in common adult-onset forms of disease. Recent studies have suggested possible therapeutic targets for some patients with early-onset glaucoma based on the molecular and cellular events caused by MYOC, OPTN and TBK1 mutations...
May 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28502035/prospective-observational-post-marketing-study-of-tafluprost-for-glaucoma-and-ocular-hypertension-effectiveness-and-treatment-persistence
#15
Yasuaki Kuwayama, Masako Hashimoto, Reiko Kakegawa, Akio Nomura, Fumiki Shimada
INTRODUCTION: The aim of this study was to investigate the long-term intraocular pressure (IOP)-lowering effect and safety of tafluprost, a prostaglandin analogue, in actual clinical practice and to determine persistency of tafluprost as an indicator of its benefit-risk balance. METHODS: This was a large-scale, post-marketing, multicenter, non-interventional, open-label, long-term study. Patients with glaucoma or ocular hypertension who initiated tafluprost treatment were registered and prospectively observed over a 2-year period in the real-world setting in Japan...
May 13, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28499984/systemic-pten-akt1-mtor-pathway-activity-in-patients-with-normal-tension-glaucoma-and-ocular-hypertension-a-case-series
#16
Gerassimos Lascaratos, Kai-Yin Chau, Haogang Zhu, Despoina Gkotsi, Deborah Kamal, Ivan Gout, Philip J Luthert, Anthony H V Schapira, David F Garway-Heath
Glaucoma is the most common optic neuropathy in humans and the leading cause of irreversible blindness worldwide. Its prevalence and incidence increase exponentially with ageing and raised intraocular pressure (IOP), while increasing evidence suggests that systemic mitochondrial abnormalities may also be implicated in its pathogenesis. We have recently shown that patients who have not developed glaucoma despite being exposed for many years to high IOP (ocular hypertension - OHT) have more efficient mitochondria, measured in peripheral blood lymphocytes, when compared to age-similar controls and fast progressing normal tension glaucoma (NTG) patients...
May 9, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28486275/evaluation-of-optic-nerve-head-and-peripapillary-choroidal-vasculature-using-swept-source-optical-coherence-tomography-angiography
#17
Kyeong Ik Na, Won June Lee, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: The authors visualized arterioles from the peripapillary choroid to the optic nerve head in vivo, using swept-source optical coherence tomography angiography. METHODS AND RESULTS: In this case series, we present 3 eyes with visible centripetal branches from the peripapillary choroid. The 3 eyes were diagnosed as glaucoma suspect, normal-tension glaucoma, and primary open-angle glaucoma. In the en face projection images of the choroidal layer, obtained by swept-source optical coherence tomography angiography, the vessels from the peripapillary choroid to the optic nerve head were observed in all 3 eyes; one of them was further evaluated by indocyanine green angiography using the Heidelberg retina angiograph...
July 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28484644/long-term-clinical-course-of-normal-tension-glaucoma-20-years-of-experience
#18
Sang Wook Jin, Seung Yoon Noh
Purpose. The purpose of this study was to investigate the long-term clinical course of NTG patients who initiated intraocular pressure- (IOP-) lowering therapy. Methods. The present study included 72 normal-tension glaucoma (NTG) patients. The mean deviation (MD) was measured with visual fields. Nocturnal hypotension with weighted standard deviation (wSD) was determined by 24-hour ambulatory blood pressure monitoring. To identify risk factors for NTG progression, linear logistic regression analysis was employed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28452990/relationship-between-the-optic-nerve-sheath-diameter-and-lumbar-cerebrospinal-fluid-pressure-in-patients-with-normal-tension-glaucoma
#19
A Pircher, M Montali, J Berberat, L Remonda, H E Killer
PurposeTo investigate on the relationship between the optic nerve sheath diameter (ONSD) and the lumbar cerebrospinal fluid pressure (CSF-p) in Caucasian patients with normal tension glaucoma (NTG).Patients and methodsRetrospective analysis of medical records of patients with open-angle glaucoma in the period from 2005 to 2015 from the Ophthalmology Department, Cantonal Hospital Aarau, Switzerland was performed. A total of 38 patients (mean age 68.6±11.3 years, 21 females and 17 males) fulfilled the diagnostic criteria of NTG and underwent computed tomography (CT) of the orbit and lumbar puncture (LP)...
April 28, 2017: Eye
https://www.readbyqxmd.com/read/28435208/is-high-myopia-a-risk-factor-for-visual-field-progression-or-disk-hemorrhage-in-primary-open-angle-glaucoma
#20
Koji Nitta, Kazuhisa Sugiyama, Ryotaro Wajima, Gaku Tachibana
PURPOSE: The purpose of this study was to clarify differences between highly myopic and non-myopic primary open-angle glaucoma (POAG) patients, including normal-tension glaucoma patients. PATIENTS AND METHODS: A total of 269 POAG patients were divided into two groups: patients with ≥26.5 mm of axial length (highly myopic group) and patients with <24.0 mm of axial length (non-myopic group). RESULTS: We analyzed 53 highly myopic and 93 non-myopic POAG patients...
2017: Clinical Ophthalmology
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