keyword
MENU ▼
Read by QxMD icon Read
search

Tension normal glaucoma

keyword
https://www.readbyqxmd.com/read/29775216/neuroimmflammation-and-microglia-in-glaucoma-time-for-a-paradigm-shift
#1
REVIEW
Xin Wei, Kin-Sang Cho, Eric F Thee, Martine J Jager, Dong Feng Chen
Glaucoma is a complex neurodegenerative disease with many clinical subtypes. Some of its rare forms include pigmentary glaucoma, uveitic glaucoma and congenital glaucoma. While they all share common features of progressive retinal ganglion cell (RGC) loss, optic nerve damage and corresponding visual field loss, the exact mechanisms underlying glaucomatous neuron loss are not clear. This has largely hindered the development of a real cure for this disease. Elevated intraocular pressure (IOP) is a known major risk factor of glaucoma; however, progressive degeneration of RGCs and axons can also be found in patients with a normal IOP, i...
May 18, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29757809/applicability-of-isnt-rule-using-bmo-mrw-to-differentiate-between-healthy-and-glaucomatous-eyes
#2
Do Young Park, Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: We evaluated the applicability of the ISNT rule using Bruch's membrane opening minimum rim width (BMO-MRW) in healthy eyes and eyes with normal tension glaucoma (NTG). METHODS: 124 healthy eyes and 136 NTG eyes were analyzed. Using two-dimensional disc photographs, neuroretinal rim (NRR) thickness was measured at the superior, inferior, nasal, and temporal sides of the optic disc. Using spectral domain-optical coherence tomography (SD-OCT), BMO-MRW was measured at the same regions...
May 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29750124/a-small-disc-area-is-a-risk-factor-for-visual-field-loss-progression-in-primary-open-angle-glaucoma-the-glaucoma-stereo-analysis-study
#3
Yasushi Kitaoka, Masaki Tanito, Yu Yokoyama, Koji Nitta, Maki Katai, Kazuko Omodaka, Toru Nakazawa
Purpose: The Glaucoma Stereo Analysis Study, a cross-sectional multicenter collaborative study, used a stereo fundus camera (nonmyd WX) to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients. We compared the associations of each parameter between the visual field loss progression group and no-progression group. Methods: The study included 187 eyes of 187 patients with primary open-angle glaucoma or normal-tension glaucoma. We divided the mean deviation (MD) slope values of all patients into the progression group (<-0...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750123/visual-subfield-progression-in-glaucoma-subtypes
#4
Wei-Wen Su, Shian-Sen Hsieh, Shih-Tsung Cheng, Cheng-Wen Su, Wei-Chi Wu, Henry Shen-Lih Chen
Purpose: To investigate visual field progression pattern and factors associated with progression in patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and chronic angle-closure glaucoma (CACG). Methods: The raw data of the 30-2 Humphrey Field Analyzer from glaucoma patients with definite visual field progression were processed with pointwise linear regression (PLR) analysis. The rate of change of retinal threshold sensitivity in the ten glaucoma hemifield test (GHT) zones, the upper and the lower hemifields, and the whole field was evaluated and was correlated with patients' basic demographic data...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29726764/letter-to-the-editor-low-icp-and-normal-tension-glaucoma-optic-nerve-damage-due-to-barotraumatic-factors-failure-of-csf-dynamics-or-both
#5
Peter Wostyn, Veva De Groot, Debby Van Dam, Kurt Audenaert, Peter Paul De Deyn, Hanspeter Esriel Killer
No abstract text is available yet for this article.
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29713904/gene-expression-changes-in-the-retina-after-systemic-administration-of-aldosterone
#6
Aoi Ono, Kazuyuki Hirooka, Yuki Nakano, Eri Nitta, Akira Nishiyama, Akitaka Tsujikawa
PURPOSE: Retinal ganglion cell (RGC) loss associated with thinning of the retinal nerve fiber layer without elevated intraocular pressure (IOP) occurs after the systemic administration of aldosterone. Since it is important to determine the mechanism of cell death independent of the IOP, we examined gene expression changes in the retina after the systemic administration of aldosterone. METHODS: Following subcutaneous implantation of an osmotic minipump into the mid-scapular region of rats, we administered an 80 μg/kg/day dose of aldosterone...
April 30, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29694605/neuroprotective-effects-of-erythropoietin-on-rat-retinas-subjected-to-oligemia
#7
Litia Alves de Carvalho, Renata Fleming, Moysés Sant'Anna, Roberta Guimarães, Adalmir Morterá Dantas, Eduardo Morizot-Leite, Leny A Cavalcante, Silvana Allodi
OBJECTIVES: Erythropoietin may have neuroprotective potential after ischemia of the central nervous system. Here, we conducted a study to characterize the protective effects of erythropoietin on retinal ganglion cells and gliotic reactions in an experimentally induced oligemia model. METHODS: Rats were subjected to global oligemia by bilateral common carotid artery occlusion and then received either vehicle or erythropoietin via intravitreal injection after 48 h; they were euthanized one week after the injection...
2018: Clinics
https://www.readbyqxmd.com/read/29677370/topical-ripasudil-suppresses-retinal-ganglion-cell-death-in-a-mouse-model-of-normal-tension-glaucoma
#8
Kei Akaiwa, Kazuhiko Namekata, Yuriko Azuchi, Hiroki Sano, Xiaoli Guo, Atsuko Kimura, Chikako Harada, Yoshinori Mitamura, Takayuki Harada
Purpose: To assess if ripasudil has a neuroprotective effect using mice with excitatory amino acid carrier 1 (EAAC1) deletion (EAAC1 knockout [KO] mice), a mouse model of normal tension glaucoma. Methods: Topical administration (5 μL/day) of two different concentrations of ripasudil (0.4% and 2%) were applied to EAAC1 KO mice from 5 to 12 weeks old. Optical coherence tomography, multifocal electroretinograms, the measurement of intraocular pressure (IOP), and histopathology analyses were performed at 5, 8, and 12 weeks old...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29675274/efficacy-and-safety-of-switching-prostaglandin-analog-monotherapy-to-tafluprost-timolol-fixed-combination-therapy
#9
Kazuyoshi Kitamura, Tatsuya Chiba, Fumihiko Mabuchi, Kiyotaka Ishijima, Shu Omoto, Fumiko Kashiwagi, Takashi Godo, Satoshi Kogure, Teruhiko Goto, Takashi Shibuya, Jhoji Tanabe, Shigeo Tsukahara, Tadaharu Tsuchiya, Toyoaki Tsumura, Takaharu Tokunaga, Osamu Hosaka, Tetsunori Saito, Kenji Kashiwagi
Purpose: To assess the efficacy and safety of switching from prostaglandin analog (PGA) monotherapy to tafluprost/timolol fixed-combination (Taf/Tim) therapy. Subjects and Methods: Patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who had received PGA monotherapy for at least 3 months were enrolled. Patients were examined at 1, 2, and 3 months after changing therapies. Subsequently, the patients were returned to PGA monotherapy...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29651628/intracranial-and-intraocular-pressure-at-the-lamina-cribrosa-gradient-effects
#10
REVIEW
Gauti Jóhannesson, Anders Eklund, Christina Lindén
PURPOSE OF REVIEW: A pressure difference between the intraocular and intracranial compartments at the site of the lamina cribrosa has been hypothesized to have a pathophysiological role in several optic nerve head diseases. This paper reviews the current literature on the translamina cribrosa pressure difference (TLCPD), the associated pressure gradient, and its potential pathophysiological role, as well as the methodology to assess TLCPD. RECENT FINDINGS: For normal-tension glaucoma (NTG), initial studies indicated low intracranial pressure (ICP) while recent findings indicate that a reduced ICP is not mandatory...
April 12, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29651342/factors-related-to-a-right-left-difference-in-visual-field-defect-in-the-eyes-with-untreated-normal-tension-glaucoma
#11
Haruka Moroi, Ayako Anraku, Kyoko Ishida, Goji Tomita
Purpose: To investigate factors related to a right-left difference in visual field defect in untreated normal tension glaucoma (NTG). Methods: The medical records of 92 patients with untreated NTG were reviewed. Ocular blood flow was evaluated with laser speckle flowgraphy, and the mean blur rate (MBR) at the optic nerve head was analyzed. Relationships between right-left differences in mean deviation (MD), intraocular pressure, MBR, spherical equivalent, central corneal thickness, and mean ocular perfusion pressure were evaluated using Spearman's rank correlation coefficient...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29651339/comparison-of-optical-coherence-tomography-angiography-and-laser-speckle-flowgraphy-for-the-diagnosis-of-normal-tension-glaucoma
#12
Asuka Takeyama, Kyoko Ishida, Ayako Anraku, Masahiro Ishida, Goji Tomita
Purpose: To compare optical coherence tomography angiography (OCT-A) and laser speckle flowgraphy (LSFG) for the diagnosis of normal-tension glaucoma (NTG). Methods: Twenty-eight eyes of 28 patients with NTG and 25 eyes of 25 normal subjects matched for age, refractive errors, systemic blood pressure, and central corneal thickness were evaluated. OCT-A was used to measure whole image vessel density, inside disc vessel density, and peripapillary vessel density; using LSFG, mean blur rate (MBR) inside the whole optic nerve head (ONH) area (MBRA ), and MBR of the vessel area (MBRV ) and tissue area (MBRT ) inside the ONH, were determined...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29625454/white-matter-abnormalities-and-correlation-with-severity-in-normal-tension-glaucoma-a-whole-brain-atlas-based-diffusion-tensor-study
#13
Rong Wang, Zuohua Tang, Xinghuai Sun, Lingjie Wu, Jie Wang, Yufeng Zhong, Zebin Xiao
Purpose: To detect injury of whole brain white matter (WM) in normal tension glaucoma (NTG) patients by using diffusion tensor imaging (DTI) and to analyze the correlations between DTI parameters and glaucoma indices. Methods: Twenty mild, 17 moderate, and 18 severe NTG patients as well as 25 normal subjects were enrolled in this study. Atlas-based diffusion tensor analysis was performed to measure the fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD)...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29606853/the-role-of-corneal-hysteresis-during-the-evaluation-of-patients-with-possible-normal-tension-glaucoma
#14
Ming Chen, Laura Kueny, Arthur L Schwartz
Purpose: There are multiple reports of the role of corneal hysteresis (CH) as an independent risk factor for the diagnosis and risk of progression of normal-tension glaucoma (NTG). Our study measured CH with the Ocular Response Analyzer (ORA) in patients with intraocular pressure (IOP) <21 mmHg to investigate if a low CH would identify NTG in this Asian-based practice. Methods: This was a prospective cross-sectional study of patients who underwent routine eye examination during 2016 in a private practice in Honolulu, Hawaii, where most patients are Asian...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29593379/the-clinical-effectiveness-of-tafluprost-on-japanese-normal-tension-glaucoma-patients
#15
Akio Nomura, Hirotaka Osaki, Fumiki Shimada, Yasuaki Kuwayama
Purpose: This study evaluates the effect of tafluprost on visual field progression in normal-tension glaucoma (NTG) in a Japanese population under daily clinical practice settings. Patients and methods: This is a post-marketing, multicenter, non-interventional, observational study. Patients with NTG who initiated tafluprost treatment were registered and prospectively observed for 2-3 years to investigate its effectiveness on visual field progression and intraocular pressure (IOP) and safety in Japan...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29593269/laser-speckle-flowgraphy-derived-characteristics-of-optic-nerve-head-perfusion-in-normal-tension-glaucoma-and-healthy-individuals-a-pilot-study
#16
Anna Sophie Mursch-Edlmayr, Nikolaus Luft, Dominika Podkowinski, Michael Ring, Leopold Schmetterer, Matthias Bolz
The purpose of this prospective, case control study was to investigate the differences in optic nerve head blood flow measured with Laser Speckle Flowgraphy (LSFG) between Caucasian patients with normal tension glaucoma and healthy subjects. It included 20 eyes from 20 Caucasian patients with diagnosis of normal tension glaucoma and 20 eyes from age- and sex-matched healthy individuals. In the glaucoma group the antiglaucomatous therapy was paused 3 weeks prior to the investigations. Measurement of optic nerve head blood flow was performed with LSFG...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29565276/dietary-niacin-and-open-angle-glaucoma-the-korean-national-health-and-nutrition-examination-survey
#17
Kyoung In Jung, Yong Chan Kim, Chan Kee Park
Glaucoma is a leading cause of loss of sight. High intraocular pressure (IOP) is the most critical risk factor. However, glaucoma develops even within a normal IOP range. Normal tension glaucoma (NTG) is more common in Asia, whereas high tension glaucoma is more common in Western countries. The pathogenesis of glaucoma, especially NTG, is poorly understood. We evaluated the correlation between dietary nutrient intake and glaucoma using data from subjects ≥40 years old from the ongoing, nationwide, population-based study, the Korean National Health and Nutrition Examination Survey V (2008-2012)...
March 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29557833/location-of-disc-hemorrhage-and-direction-of-progression-in-glaucomatous-retinal-nerve-fiber-layer-defects
#18
Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: To investigate the relationship between glaucomatous disc hemorrhage (DH) location with respect to the nasal or temporal margin of the retinal nerve fiber layer defect (RNFLD) and the direction of RNFLD widening. MATERIALS AND METHODS: This is a retrospective, cross-sectional study. Patients with any documented episode of glaucomatous DH throughout the follow-up period, and definite RNFLD widening on retinal nerve fiber layer (RNFL) photos were analyzed...
March 19, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29532640/impaired-cerebrospinal-fluid-dynamics-along-the-entire-optic-nerve-in-normal-tension-glaucoma
#19
Achmed Pircher, Margherita Montali, Peter Wostyn, Joachim Pircher, Jatta Berberat, Luca Remonda, Hanspeter E Killer
PURPOSE: To investigate the cerebrospinal fluid (CSF) dynamics along the entire optic nerve (ON) in patients with normal-tension glaucoma (NTG). METHODS: Retrospective analysis of computed tomographic (CT) cisternographies in Caucasian patients with NTG. Fifty-six patients (99 of 112 eyes) fulfilled the diagnostic criteria of NTG and underwent CT-cisternography. Twelve subjects without NTG (24 eyes) served as controls. Contrast-loaded cerebrospinal fluid (CLCSF) density measurements in Hounsfield units (HU) were performed at four defined regions along the ON and in the basal cistern...
March 12, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29523993/structural-changes-of-macular-inner-retinal-layers-in-early-normal-tension-and-high-tension-glaucoma-by-spectral-domain-optical-coherence-tomography
#20
Florian S M Edlinger, Laura M Schrems-Hoesl, Christian Y Mardin, Robert Laemmer, Friedrich E Kruse, Wolfgang A Schrems
PURPOSE: Assessment of the diagnostic ability of segmented macular inner retinal layer thickness and peripapillary retinal nerve fiber layer (pRNFL) measured by spectral-domain optical coherence tomography (SD-OCT) in patients with normal-tension (NT) and high-tension (HT) perimetric and preperimetric glaucoma. METHODS: The 212 participants included 45 healthy subjects, 55 patients with ocular hypertension, 56 patients with preperimetric glaucoma, and 56 patients with perimetric glaucoma...
March 9, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
keyword
keyword
84944
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"