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Tension normal glaucoma

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https://www.readbyqxmd.com/read/29150215/lifestyles-guide-and-glaucoma-ii-diet-supplements-drugs-sleep-pregnancy-and-systemic-hypertension
#1
A Antón-López, J Moreno-Montañés, S Duch-Tuesta, P Corsino Fernández-Vila, J García-Feijoo, E Millá-Griñó, F J Muñoz-Negrete, L Pablo-Júlvez, I Rodríguez-Agirretxe, J L Urcelay-Segura, F Ussa-Herrera, M P Villegas-Pérez
PURPOSE: To establish evidence based guidelines to advise patients on the relationship between habits, diet, certain circumstances, diseases and glaucoma. METHODS: Review of all published articles on glaucoma and sports or other activities. The papers were classified according to the level of scientific evidence based on the Oxford Centre for Evidence-based Medicine classification. RESULTS: The evidence on the relationship between diet or supplements and the incidence or progression of glaucoma is insufficient to make a general recommendation for glaucoma patients...
November 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29148901/glaucoma-in-patients-with-shunt-treated-normal-pressure-hydrocephalus
#2
Pasquale Gallina, Alfonso Savastano, Eleonora Becattini, Simone Orlandini, Antonio Scollato, Stanislao Rizzo, Giulia Carreras, Nicola Di Lorenzo, Berardino Porfirio
OBJECTIVE Changes in the pressure gradient between intraocular and intracranial compartments at the lamina cribrosa level are a possible explanation of normal tension glaucoma (NTG). Shunt-treated normal pressure hydrocephalus (NPH) is a model for testing whether the increase (time from disease onset to CSF shunt placement, i.e., "protection period") and decrease (time from shunt placement to observation, i.e., "exposure period") in intracranial pressure (ICP) are glaucoma protective or risk factors, respectively...
November 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29118453/prediction-of-visual-field-progression-in-patients-with-primary-open-angle-glaucoma-mainly-including-normal-tension-glaucoma
#3
Koji Nitta, Ryotaro Wajima, Gaku Tachibana, Sachie Inoue, Tatsuya Ohigashi, Naomi Otsuka, Hiroaki Kurashima, Kazunori Santo, Masayo Hashimoto, Hidetoshi Shibahara, Mai Hirukawa, Kazuhisa Sugiyama
An objective method to predict individual visual field progression will contribute to realise personalised medication. The purpose of this study was to establish a predictive formula for glaucomatous visual field progression in patients with Primary open-angle glaucoma, mainly including normal tension glaucoma. This study was a large-scale, longitudinal and retrospective study including 498 eyes of 312 patients visiting from June 2009 to May 2015. In this analysis, 191 eyes of 191 patients meeting all eligible criteria were used...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110658/effect-of-primary-phacoviscocanalostomy-viscocanalostomy-on-intraocular-pressure-of-normal-tension-glaucoma-patients-3-year-results
#4
Derek Kwun-Hong Ho, Adesuwa Garrick, Seemeen Aazem, Divya Mathews
BACKGROUND: The objective of this study was to evaluate the efficacy of Viscocanalostomy/Phacoviscocanalostomy (VC/PVC) in lowering intraocular pressure (IOP) in Normal Tension Glaucoma (NTG) patients. METHODS: Retrospective electronic database review of patients who underwent VC/PVC for NTG between December 2009 and November 2011 at Stanley eye unit in Abergele Hospital. Goldmann applanation tonometry (GAT) was used for all IOP measurements which were taken at the time of listing for surgery and at 1 day, 1 week, 1 month, then 3-monthly up to 1 year, then half-yearly up to 3 years post operatively...
November 6, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29109895/are-all-retinal-nerve-fiber-layer-defects-on-optic-coherence-tomography-glaucomatous
#5
Sirel Gür Güngör, Akman Ahmet
Objectives: In this study, we investigated the patients who were referred to our clinic with a prediagnosis of glaucoma based on retinal nerve fiber layer (RNFL) defects on optic coherence tomography (OCT) but were determined to have nonglaucomatous RNLF defects upon detailed examination. Materials and Methods: The ophthalmic examination notes, OCT images, Heidelberg retinal tomography (HRT) II and fundus photographs of 357 patients were retrospectively evaluated...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29104631/ocular-pulse-amplitude-in-different-types-of-glaucoma-using-dynamic-contour-tonometry-diagnosis-and-follow-up-of-glaucoma
#6
Lingyan Cheng, Yuzhi Ding, Xuanchu Duan, Zhifeng Wu
The aim of the present study was to compare the ocular pulse amplitude (OPA) in patients with different types of glaucoma using dynamic contour tonometry (DCT), to evaluate ocular and systemic factors associated with the OPA and to verify whether OPA measured by DCT is an independent predictor for glaucoma diagnosis. A total of 217 eyes of 217 participants in the following five groups were included in this cross-sectional study: Chronic angle closure glaucoma (CACG), primary open angle glaucoma, normal tension glaucoma (NTG), suspected open angle glaucoma (SOAG) and normal control (NC)...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29096996/normal-tension-glaucoma-has-normal-intracranial-pressure-a-prospective-study-of-intracranial-pressure-and-intraocular-pressure-in-different-body-positions
#7
Christina Lindén, Sara Qvarlander, Gauti Jóhannesson, Elias Johansson, Fanny Östlund, Jan Malm, Anders Eklund
PURPOSE: To test the hypothesis that normal-tension glaucoma (NTG) is caused by an increased pressure difference across the lamina cribrosa (LC) related to a low intracranial pressure (ICP). DESIGN: Prospective case-control study. PARTICIPANTS: Thirteen NTG patients (9 women; median 71 [range: 56-83] years) were recruited for investigation with the same protocol as 11 healthy volunteers (8 women; 47 [30-59] years). A larger control group (n = 51; 30 women; 68 [30-81] years) was used only for ICP comparison in supine position...
October 30, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29090841/oxygen-venular-saturation-correlates-with-a-functional-loss-in-primary-open-angle-glaucoma-and-normal-tension-glaucoma-patients
#8
Takeru Shimazaki, Kazuyuki Hirooka, Yuki Nakano, Eri Nitta, Kaori Ukegawa, Akitaka Tsujikawa
PURPOSE: To investigate whether there are differences in retinal oxygen saturation in upper and lower visual field hemispheres in primary open-angle glaucoma (POAG) and in normal-tension glaucoma (NTG). METHODS: This study enrolled POAG and NTG patients exhibiting differences between the upper and lower total deviation (TD) that were either more than 10 or <5 dB. Retinal oxygen saturation measurements in these patients with glaucoma were performed by a non-invasive spectrophotometric retinal oximeter...
November 1, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29077716/evaluation-of-retinal-nerve-fiber-layer-defect-using-wide-field-en-face-swept-source-oct-images-by-applying-the-inner-limiting-membrane-flattening
#9
Naoki Miura, Kazuko Omodaka, Koudai Kimura, Akiko Matsumoto, Tsutomu Kikawa, Seri Takahashi, Naoko Takada, Hidetoshi Takahashi, Kazuichi Maruyama, Masahiro Akiba, Tetsuya Yuasa, Toru Nakazawa
PURPOSE: The assessment of retinal nerve fiber layer defects (RNFLDs) is a useful part of glaucoma care. Here, we obtained en-face images of retinal layers below the inner limiting membrane (ILM) with swept source-optical coherence tomography (SS-OCT), and measured RNFLD angle with new software. METHODS: This study included 105 eyes of 105 normal tension glaucoma (NTG) patients (age, 59.8 ± 13.2). Exclusion criteria were best-corrected visual acuity < 0.5, axial length > 28 mm, non-glaucoma ocular disease, and systemic disease affecting the visual field...
2017: PloS One
https://www.readbyqxmd.com/read/29069012/is-atrial-fibrillation-a-risk-factor-for-normal-tension-glaucoma
#10
Anna Zaleska-Żmijewska, Maciej Janiszewski, Zbigniew M Wawrzyniak, Marek Kuch, Jerzy Szaflik, Jacek P Szaflik
Glaucoma (GL) and atrial fibrillation (AF) are diseases of significant social importance. Cardiovascular disorders such as systemic hypertension, hypotension, increased blood viscosity, vasospasm, and diabetes are potential risk factors of GL, especially when intraocular pressure is not elevated. Only a few studies have reported a possible connection between cardiac arrhythmias and GL. The purpose of this study was to evaluate the risk of GL in patients with AF.A total of 117 patients were included in the study, 79 with AF (AF group) and 38 with sinus rhythm (Control group), matched for age and sex...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29064608/diffuse-brain-damage-in-normal-tension-glaucoma
#11
Antonio Giorgio, Jian Zhang, Francesco Costantino, Nicola De Stefano, Paolo Frezzotti
Brain changes within and beyond the visual system have been demonstrated in primary open angle glaucoma (POAG), the most common type of glaucoma. These changes have been often interpreted as a neurodegenerative process due, at least partially, to the raised intraocular pressure (IOP). In this context, normal tension glaucoma (NTG), a form of POAG with IOP <21 mm Hg despite the typical glaucomatous findings, represents the most suitable model of glaucoma to test the validity of this hypothesis. We acquired multimodal brain MRI in NTG patients (n = 17) and compared them with demographically matched groups of POAG patients with raised IOP (n = 17) and normal controls (NC, n = 29)...
October 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29049724/patients-with-normal-tension-glaucoma-have-relative-sparing-of-the-relative-afferent-pupillary-defect-compared-to-those-with-open-angle-glaucoma-and-elevated-intraocular-pressure
#12
COMPARATIVE STUDY
Mitchell Lawlor, Ana Quartilho, Catey Bunce, Neil Nathwani, Emily Dowse, Debbie Kamal, Gus Gazzard
Purpose: We determined whether there is relative sparing of pupil function in glaucoma patients with normal pressures compared to those with high pressures. Methods: A cross-sectional study was done of 68 patients with primary open angle glaucoma (POAG): 38 had normal IOPs on all-day phasing before treatment (never >21 mm Hg), with confirmed progression of glaucomatous optic neuropathy (NTG) and 30 had glaucomatous optic neuropathy associated with elevated intraocular pressures (>25 mm Hg; HP-POAG)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29044063/cognitive-functions-and-normal-tension-glaucoma
#13
Akvile Daveckaite, Evelina Grusauskiene, Kestutis Petrikonis, Antanas Vaitkus, Lina Siaudvytyte, Ingrida Januleviciene
PURPOSE: Only a few studies have analyzed the potential link between glaucoma and cognitive function impairment. They have found controversial results. This study aims to perform quick cognitive function assessment with clock drawing test (CDT) using two different scoring systems and compare between normal tension glaucoma (NTG) and cataract patients. METHODS: Totally, 30 NTG and 30 patients with cataracts were included in a prospective, pilot study. The predrawn circle was given, and patients were asked to draw the clock showing a time of 11:10...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29040292/intereye-comparison-of-ocular-factors-in-normal-tension-glaucoma-with-asymmetric-visual-field-loss-in-korean-population
#14
Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: To identify ocular parameters corresponding to asymmetric visual field (VF) loss in normal tension glaucoma (NTG) through intereye comparisons. PATIENTS AND METHODS: Medical records of NTG patients with asymmetric and symmetric VF losses were retrospectively reviewed. The criterion for asymmetry in VF was 6 dB difference of mean deviation. Refractive error, intraocular pressure (IOP), central corneal thickness, ovality index, and peripapillary atrophy (PPA)/disc area ratio were obtained from each patient...
2017: PloS One
https://www.readbyqxmd.com/read/29040280/quantitative-analysis-of-neural-tissues-around-the-optic-disc-after-panretinal-photocoagulation-in-patients-with-diabetic-retinopathy
#15
Hyun Seung Yang, June-Gone Kim, Jae Bong Cha, Young In Yun, Jong Hoon Park, Jong Eun Woo
In this retrospective cross-sectional study, we quantitatively analyzed the tomographic features in the neural tissues around the optic disc in patients with diabetic retinopathy with and without panretinal photocoagulation. We analyzed 206 eyes, comprising 33 normal eyes in subjects without diabetes (group I), 30 eyes without diabetic retinopathy (group II), 66 eyes with non-proliferative diabetic retinopathy (group III), 45 eyes with panretinal photocoagulation (group IV), and 32 eyes with normal tension glaucoma (group V)...
2017: PloS One
https://www.readbyqxmd.com/read/29027057/comparative-analysis-of-mean-retinal-thickness-measured-using-sd-oct-in-normal-young-or-old-age-and-glaucomatous-eyes
#16
Jun Won Jang, Myung Won Lee, Kyong Jin Cho
PURPOSE: To evaluate changes in macular thickness, ganglion cell layer/inner plexiform layer (GCL/IPL) thickness, and retinal nerve fiber layer (RNFL) thickness in normal eyes and glaucomatous eyes using spectral domain optical coherence tomography (SD-OCT). METHODS: We enrolled 89 eyes (all left eyes), including 45 (of 45 patients) eyes with glaucoma and 44 (of 44 patients) normal eyes. The data from macular measurements using spectral domain optical coherence tomography were analyzed according to groups divided by age and glaucoma status...
October 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28991617/goniotomy-with-a-single-use-dual-blade-short-term-results
#17
Michael D Greenwood, Leonard K Seibold, Nathan M Radcliffe, Syril K Dorairaj, Ahmad A Aref, Jesús Jimenez Román, Gabriel S Lazcano-Gomez, Jason K Darlington, Suhail Abdullah, Mark C Jasek, Khaled A Bahjri, John P Berdahl
PURPOSE: To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of a single-use dual blade (Kahook) in patients with mild to end-stage glaucoma. SETTING: International multicenter ophthalmic care centers. DESIGN: Prospective interventional case series. METHODS: Consecutive patients with glaucoma who had phacoemulsification plus goniotomy with the single-use dual blade were enrolled in this study. Each center collected deidentified clinical data, including preoperative and postoperative IOP, medication use, adverse events, and whether additional surgery was required during a 6-month follow-up...
September 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28984711/genomic-organization-of-tbk1-copy-number-variations-in-glaucoma-patients
#18
Adam P DeLuca, L M Alward Wallace, Jeffrey Liebmann, Robert Ritch, Kazuhide Kawase, Young H Kwon, Alan L Robin, Edwin M Stone, Todd E Scheetz, John H Fingert
BACKGROUND: Approximately 1% of normal tension glaucoma cases are caused by TANK binding kinase 1 (TBK1) gene duplications and triplications. However, the precise borders and orientation of these TBK1 gene copy number variations (CNVs) on chromosome 12 are unknown. METHODS: We determined the exact borders of TBK1 CNVs and the orientation of duplicated or triplicated DNA segments in five NTG patients with different TBK1 mutations using whole genome sequencing. RESULTS: Tandemly duplicated chromosome segments spanning the TBK1 gene were detected in four NTG patients, each with unique borders...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28979091/intraocular-pressure-and-visual-field-changes-in-normal-tension-glaucoma-patients-treated-using-either-unoprostone-or-latanoprost-a-prospective-comparative-study
#19
Daisuke Takemoto, Tomomi Higashide, Yoshiaki Saito, Shinji Ohkubo, Sachiko Udagawa, Hisashi Takeda, Kazuhisa Sugiyama
PURPOSE: We conducted a prospective study in patients with normal-tension glaucoma (NTG) who received either isopropyl unoprostone or latanoprost. We compared the drugs in terms of their effects on intraocular pressure (IOP) and visual field loss progression over a 3-year period. STUDY DESIGN: Prospective, randomized controlled study. METHODS: We enrolled 48 patients with newly diagnosed NTG at Kanazawa University Hospital. Eligible patients were randomly allocated (1:1) to receive either unoprostone or latanoprost ophthalmic solutions...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28973002/usefulness-of-axonal-tract-dependent-oct-macular-sectors-for-evaluating-structural-change-in-normal-tension-glaucoma
#20
Kazuko Omodaka, Tsutomu Kikawa, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Haruka Sato, Junko Ohuchi, Akiko Matsumoto, Hidetoshi Takahashi, Masahiro Akiba, Toru Nakazawa
PURPOSE: To identify sectors of the optical coherence tomography (OCT) macular map that could be used to effectively assess structural progression in patients with normal-tension glaucoma (NTG). METHODS: This study examined 117 eyes of 117 NTG patients to establish axonal tract-dependent macular sectors, and also examined a separate group of 122 eyes of 81 NTG patients to evaluate the ability of these sectors to reveal glaucoma progression. Longitudinal data, including macular maps from at least 5 OCT examinations performed over at least 2 years, was available for all patients in this group...
2017: PloS One
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