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Tension normal glaucoma

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https://www.readbyqxmd.com/read/28088510/association-between-nocturnal-blood-pressure-dips-and-optic-disc-hemorrhage-in-patients-with-normal-tension-glaucoma
#1
Junki Kwon, Jinyoung Lee, Jaewan Choi, Dawoon Jeong, Michael S Kook
PURPOSE: To investigate the effect of nocturnal blood pressure (BP) dips on the occurrence of optic disc hemorrhage (ODH) in normal-tension glaucoma (NTG) patients and determine whether ODH is associated with greater likelihood of visual field progression (VFP). DESIGN: Prospective case-control study. METHODS: This study enrolled 698 eyes of 349 consecutive NTG patients who were ≥40 years old, underwent 24 hour intraocular pressure and ambulatory BP monitoring in the habitual position, were examined for ODH every 4-6 months with optic disc photography, and had ≥ five reliable VF tests with minimum follow-up of 3 years...
January 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28079658/normal-tension-glaucoma-and-low-cerebrospinal-fluid-pressure
#2
Imran H Yusuf, Gokularaj Ratnarajan, Richard S Kerr, John F Salmon
No abstract text is available yet for this article.
January 10, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28079654/retinal-oximetry-in-subjects-with-glaucomatous-hemifield-asymmetry
#3
Zhu Li Yap, Charles Ong, Yi Fang Lee, Andrew Tsai, Clarissa Cheng, Monisha E Nongpiur, Shamira A Perera
PURPOSE: Although some studies suggest a strong link between retinal vessel oxygenation and damage to the retinal nerve fiber layer (RNFL) seen in glaucoma, it has yet to be conclusively proven. This study compares intraocular retinal oximetry in glaucomatous eyes displaying asymmetrically affected hemifields across different subgroups of glaucoma, namely primary angle closure glaucoma (PACG), primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG). METHODS: In this prospective cross-sectional study, 99 patients (PACG, n=28; POAG, n=37; NTG, n=34) underwent retinal oxygenation and vessel caliber measurements using the Oxymap T1 Retinal Oximeter, Cirrus optical coherence tomography, and Humphrey visual field testing...
January 10, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28079653/comparison-of-impact-of-monocular-and-integrated-binocular-visual-fields-on-vision-related-quality-of-life
#4
Yeoun Sook Chun, Dong Ik Lee, Jaein Kwon, In Ki Park
PURPOSE OF THE STUDY: The purpose of the study was to investigate the relationship between vision-related quality of life (VRQOL) and mean deviation (MD) of the monocular visual field and integrated binocular visual field (IBVF). METHODS: One hundred eighty VFs (90 pairs) obtained from 90 patients with normal tension glaucoma were included. VRQOL was evaluated using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). IBVF was calculated using maximal sensitivity and binocular summation and IBVF MD was calculated...
January 10, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28073365/neurophthalmological-conditions-mimicking-glaucomatous-optic-neuropathy-analysis-of-the-most-common-causes-of-misdiagnosis
#5
Diego Torres Dias, Michele Ushida, Roberto Battistella, Syril Dorairaj, Tiago Santos Prata
BACKGROUND: To analyze the most common neurophthalmological conditions that may mimic glaucomatous optic neuropathy and to determine which most often lead to misdiagnosis when evaluated by a glaucoma specialist. METHODS: We reviewed the charts of consecutive patients with optic neuropathies caused by neurophthalmological conditions screened in a single Eye Clinic within a period of 24 months. Within these enrolled patients, we selected the eyes whose fundoscopic appearance could resemble glaucoma based in pre-defined criteria (vertical cup-to-disc ratio ≥0...
January 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28040851/impact-of-laser-pulse-duration-on-the-reduction-of-intraocular-pressure-during-selective-laser-trabeculoplasty
#6
Spela Stunf Pukl, Brigita Drnovšek-Olup
PURPOSE: To evaluate the efficacy of selective laser trabeculoplasty (SLT) to lower intraocular pressure (IOP) in patients with primary open-angle glaucoma (POAG), normal tension glaucoma (NTG) or ocular hypertension (OHT), when performed with laser pulse duration of 1 ns compared with standard 3-5 ns. METHODS: Bilateral SLT with a 532 nm Q-switched neodymium-doped yttrium aluminium garnet laser was conducted in 30 patients (60 eyes) with POAG (n = 5), NTG (n = 2) or OHT (n = 23)...
December 31, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/28025332/transgenic-tbk1-mice-have-features-of-normal-tension-glaucoma
#7
John H Fingert, Kathy Miller, Adam Hedberg-Buenz, Ben R Roos, Carly J Lewis, Robert F Mullins, Michael G Anderson
Duplication of the TBK1 gene is associated with 1-2% of normal tension glaucoma, a common cause of vision loss and blindness that occurs without grossly abnormal intraocular pressure. We generated a transgenic mouse that has one copy of the human TBK1 gene (native promoter and gene structure) incorporated into the mouse genome (Tg-TBK1). Expression of the TBK1 transgene in the retinae of these mice was demonstrated by real-time PCR. Using immunohistochemistry TBK1 protein was predominantly localized to the ganglion cell layer of the retina, the cell type most affected by glaucoma...
December 26, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/28002190/a-comment-on-juvenile-onset-normal-tension-glaucoma-from-chronic-recurrent-low-cerebrospinal-fluid-pressure-j-glaucoma-2016-25-e738-e740
#8
Pasquale Gallina, Alfonso Savastano, Eleonora Becattini, Simone Orlandini, Stanislao Rizzo, Berardino Porfirio
No abstract text is available yet for this article.
December 20, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27984835/-phenomenology-and-clinical-relevance-of-the-flammer-syndrome
#9
K Konieczka, J Flammer
The Flammer syndrome (FS) describes the phenotype of people with a predisposition for an altered reaction of the blood vessels to stimuli like coldness, emotional stress or high altitude. Frequent symptoms are: cold hands and/or feet, low blood pressure, prolonged sleep onset time, reduced feeling of thirst, increased sensitivity to odour, pain, vibration and certain drugs. SF subjects are often ambitious and successful but also perfectionistic and sometimes brooding. Frequent signs are: altered gene expression, prolonged blood flow cessation in nailfold capillaroscopy after cold provocation, reduced autoregulation of ocular blood flow, and reduced vasodilation after stimulation with flickering light...
December 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27966838/translaminar-pressure-in-caucasian-normal-tension-glaucoma-patients
#10
Achmed Pircher, Luca Remonda, Robert N Weinreb, Hanspeter E Killer
PURPOSE: The aim of this study was to examine the translaminar pressure difference (TLP) in Caucasian patients with normal tension glaucoma (NTG) and its possible impact onto the pathogenesis of NTG. METHODS: Retrospective analysis of medical records of patients with open-angle glaucoma (OAG) in the period from 2005 to 2015 from the Ophthalmology Department, Cantonal Hospital Aarau, Switzerland. A total of 67 eyes of 38 patients (mean age 68.6 ± 11.3 years, 21 women and 17 men) fulfilled the diagnostic criteria of progressive NTG and underwent lumbar puncture (LP) during computer-assisted cisternography (CT - cisternography)...
December 14, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27965889/elevated-plasma-endothelin-1-levels-in-normal-tension-glaucoma-and-primary-open-angle-glaucoma-a-meta-analysis
#11
REVIEW
Shengjie Li, Aiping Zhang, Wenjun Cao, Xinghuai Sun
Purpose. The aim of this meta-analysis was to clarify the association between the plasma endothelin-1 level and the risks of normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG). Methods. Relevant publications were collected from three databases including PubMed, EMBASE, and the Web of Science through December 31, 2015. In this study, the terms "(endothelin OR ET) AND glaucoma" were searched. Review Manager 5.2 was used to process the data. Results. Seven studies (212 cases, 164 controls) were included for the NTG analysis...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27959943/circadian-patterns-of-intraocular-pressure-fluctuation-among-normal-tension-glaucoma-optic-disc-phenotypes
#12
Yeji Moon, Junki Kwon, Da Woon Jeong, Jin Young Lee, Jong Rak Lee, Seungbong Han, Michael S Kook
OBJECTIVE: To characterize the 24-h habitual-position intraocular pressure (IOP) patterns of optic disc phenotypes (ODPs) in untreated normal-tension glaucoma (NTG) and the relationships between nocturnal IOP elevation and various clinical factors. DESIGN: Prospective, cross-sectional, observational study. METHODS: Eighty-two NTG patients with focal ischemic (FI) ODP and 82 age- and disease severity-matched NTG patients with myopic glaucomatous (MG) ODP were recruited prospectively over 3 years...
2016: PloS One
https://www.readbyqxmd.com/read/27938953/frequency-of-unplanned-interventions-in-patients-attending-for-a-presumed-routine-glaucoma-follow-up-appointment
#13
Jennifer Calafati, Zia S Pradhan, Catherine M Birt
OBJECTIVE: To determine the frequency of patient visits in which an unplanned treatment modification was required in chronic patients attending a glaucoma clinic for routine follow-up and to identify the treatment interventions most commonly employed. DESIGN: Prospective, cross-sectional study. PARTICIPANTS: A total of 630 previously stable patients attending a glaucoma clinic for routine follow-up. METHODS: This was a single-centre survey of all eligible patients returning to an academic glaucoma clinic...
December 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27916714/comparison-of-retinal-vessel-diameter-between-open-angle-glaucoma-patients-with-initial-parafoveal-scotoma-and-peripheral-nasal-step
#14
Eunjoo Yoo, Chungkwon Yoo, Tae-Eun Lee, Yong Yeon Kim
PURPOSE: To compare retinal vessel diameters (RVDs) between open-angle glaucoma (OAG) patients with initial parafoveal scotoma (PFS) and those with initial peripheral nasal step (PNS). DESIGN: Retrospective, cross-sectional study METHODS: We enrolled 151 eyes of 151 patients with OAG (83 with normal-tension glaucoma [NTG] and 68 with primary open-angle glaucoma [POAG]). The patients were categorized into the PFS and PNS groups according to the location of the initial visual field (VF) defect...
December 1, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27893105/author-response-stronger-association-of-cdkn2b-as1-variants-in-female-normal-tension-glaucoma-patients-in-a-japanese-population
#15
Kathryn P Burdon, Soo K Ng, Stuart MacGregor, Jamie E Craig
No abstract text is available yet for this article.
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27893104/stronger-association-of-cdkn2b-as1-variants-in-female-normal-tension-glaucoma-patients-in-a-japanese-population
#16
Kazuhiko Mori, Masakazu Nakano, Yuichi Tokuda, Yoko Ikeda, Morio Ueno, Chie Sotozono, Shigeru Kinoshita, Kei Tashiro
No abstract text is available yet for this article.
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27892755/association-of-single-nucleotide-polymorphisms-in-non-coding-regions-of-the-tlr4-gene-with-primary-open-angle-glaucoma-in-a-mexican-population
#17
Jose Navarro-Partida, Beatriz Alvarado Castillo, Abril Bernardette Martinez-Rizo, Ramses Rosales-Diaz, Jesus Bernardino Velazquez-Fernandez, Arturo Santos
BACKGROUND: Toll-like receptor 4 (TLR4) non-coding polymorphisms are associated to primary open angle glaucoma (POAG), normal tension glaucoma, and pseudoexfoliation glaucoma. This study was performed to determine whether non-coding single nucleotide polymorphisms (SNPs) in the TLR4 gene contribute to POAG in a Mexican population. MATERIAL AND METHODS: A total of 187 unrelated Mexican patients with POAG and 109 control subjects were included. Allelic, genotypic, and haplotypic diversity was assessed for the non-coding polymorphisms rs11536889, rs1927911, rs12377632, and rs2149356 of the TLR4 gene...
November 28, 2016: Ophthalmic Genetics
https://www.readbyqxmd.com/read/27881886/tank-binding-kinase-1-tbk1-gene-and-open-angle-glaucomas-an-american-ophthalmological-society-thesis
#18
John H Fingert, Alan L Robin, Todd E Scheetz, Young H Kwon, Jeffrey M Liebmann, Robert Ritch, Wallace L M Alward
PURPOSE: To investigate the role of TANK-binding kinase 1 (TBK1) gene copy-number variations (ie, gene duplications and triplications) in the pathophysiology of various open-angle glaucomas. METHODS: In previous studies, we discovered that copy-number variations in the TBK1 gene are associated with normal-tension glaucoma. Here, we investigated the prevalence of copy-number variations in cohorts of patients with other open-angle glaucomas-juvenile-onset open-angle glaucoma (n=30), pigmentary glaucoma (n=209), exfoliation glaucoma (n=225), and steroid-induced glaucoma (n=79)-using a quantitative polymerase chain reaction assay...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/27875487/microvascular-compromise-develops-following-nerve-fiber-layer-damage-in-normal-tension-glaucoma-without-choroidal-vasculature-involvement
#19
Eun Jung Lee, Sibum Kim, Sungsoon Hwang, Jong Chul Han, Changwon Kee
PURPOSE: To investigate capillary densities in patients with unilateral normal-tension glaucoma (NTG) and normal controls using optical coherence tomography-angiography. MATERIALS AND METHODS: We recruited 13 patients with unilateral NTG and 13 healthy controls. Optical coherence tomography-angiography was performed and pure peripapillary retinal capillary density was calculated after manually excluding large vessels and the optic disc. Paired comparison of capillary densities was performed among 3 categories of eye: NTG eye, fellow eye, and normal eye...
November 21, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27861646/effect-of-geranylgeranylacetone-on-the-protection-of-retinal-ganglion-cells-in-a-mouse-model-of-normal-tension-glaucoma
#20
Zhenyu Dong, Yasuhiro Shinmei, Yoko Dong, Saori Inafuku, Junichi Fukuhara, Ryo Ando, Nobuyoshi Kitaichi, Atsuhiro Kanda, Kohichi Tanaka, Kousuke Noda, Takayuki Harada, Shinki Chin, Susumu Ishida
Glaucoma is characterized by axonal degeneration of retinal ganglion cells (RGCs) and apoptotic death of their cell bodies, and lowering intraocular pressure is associated with an attenuation of progressive optic nerve damage. Nevertheless, intraocular pressure (IOP) reduction alone was not enough to inhibit the progression of disease, which suggests the contribution of other factors to the glaucoma pathogenesis. In this study, we investigated the cytoprotective effect of geranylgeranylacetone (GGA) on RGCs degeneration using a normal tension glaucoma (NTG) mouse model, which lacks glutamate/aspartate transporter (GLAST) and demonstrates spontaneous RGC and optic nerve degeneration without elevated intraocular pressure (IOP)...
October 2016: Heliyon
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