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https://www.readbyqxmd.com/read/28644018/the-role-of-the-crystal-structure-in-cation-exchange-reactions-involving-colloidal-cu2se-nanocrystals
#1
Graziella Gariano, Vladimir Lesnyak, Rosaria Brescia, Giovanni Bertoni, Zhiya Dang, Roberto Gaspari, Luca De Trizio, Liberato Manna
Stoichiometric Cu2Se nanocrystals were synthesized in either cubic or hexagonal (metastable) crystal structures and used as the host material in cation exchange reactions with Pb2+ ions. Even if the final product of the exchange, in both cases, was rock-salt PbSe nanocrystals, we show here that the crystal structure of the starting nanocrystals has a strong influence on the exchange pathway. The exposure of cubic Cu2Se nanocrystals to Pb2+ cations led to the initial formation of PbSe unselectively on the overall surface of the host nanocrystals, generating Cu2Se@PbSe core@shell nano-heterostructures...
June 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28643929/in-silico-and-functional-evaluation-of-pth1r-mutations-found-in-patients-with-primary-failure-of-eruption-pfe
#2
H M Hendricks, S Bencharit, W Seaman, S A Frazier-Bowers
OBJECTIVES: The genetic basis of PFE (OMIM ID: 125350) was interrogated using molecular functional studies. PFE is a disorder that results in a poor prognosis in the eruption of teeth and by extension, in treatment with a continuous archwire. We tested the hypothesis that PTH1R mutations result in loss of function due to altered protein structure to determine (i) the fate of a functional PTH1R mutation and (ii) the resulting PTH1R protein structure of each functional mutation. METHODS: We used immunofluorescence assay of COS7 cells that were transfected with either the WT or 1092delG PTH1R mutation sequence to compare the fate of the expressed protein...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28634442/mild-traumatic-brain-injury-evokes-pyramidal-neuron-axon-initial-segment-plasticity-and-diffuse-presynaptic-inhibitory-terminal-loss
#3
Michal Vascak, Jianli Sun, Matthew Baer, Kimberle M Jacobs, John T Povlishock
The axon initial segment (AIS) is the site of action potential (AP) initiation, thus a crucial regulator of neuronal activity. In excitatory pyramidal neurons, the high density of voltage-gated sodium channels (NaV1.6) at the distal AIS regulates AP initiation. A surrogate AIS marker, ankyrin-G (ankG) is a structural protein regulating neuronal functional via clustering voltage-gated ion channels. In neuronal circuits, changes in presynaptic input can alter postsynaptic output via AIS structural-functional plasticity...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28633642/prediction-and-analysis-of-three-gene-families-related-to-leaf-rust-puccinia-triticina-resistance-in-wheat-triticum-aestivum-l
#4
Fred Y Peng, Rong-Cai Yang
BACKGROUND: The resistance to leaf rust (Lr) caused by Puccinia triticina in wheat (Triticum aestivum L.) has been well studied over the past decades with over 70 Lr genes being mapped on different chromosomes and numerous QTLs (quantitative trait loci) being detected or mapped using DNA markers. Such resistance is often divided into race-specific and race-nonspecific resistance. The race-nonspecific resistance can be further divided into resistance to most or all races of the same pathogen and resistance to multiple pathogens...
June 20, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28632317/qm-mm-study-on-the-photoreactions-of-dark-and-light-adapted-states-of-a-blue-light-ytva-lov-photoreceptor
#5
Xue-Ping Chang, Yuan-Jun Gao, Wei-Hai Fang, Ganglong Cui, Walter Thiel
The dark- and light-adapted states of YtvA LOV domains exhibit distinct excited-state behavior. We have employed high-level QM(MS-CASPT2)/MM calculations to study the photochemical reactions of the dark- and light-adapted states. The photoreaction from the dark-adapted state starts with an S1→T1 intersystem crossing followed by a triplet-state hydrogen transfer from the thiol to the flavin moiety that produces a diradical intermediate, and a subsequent internal conversion that triggers a barrierless C-S bond formation in the S0 state...
June 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28631537/sustainability-in-care-through-an-ethical-practice-model
#6
Linda Nyholm, Susanne Salmela, Lisbet Nyström, Camilla Koskinen
BACKGROUND: While sustainability is a key concept in many different domains today, it has not yet been sufficiently emphasized in the healthcare sector. Earlier research shows that ethical values and evidence-based care models create sustainability in care practice. OBJECTIVE: The aim of this study was to gain further understanding of the ethical values central to the realization of sustainability in care and to create an ethical practice model whereby these basic values can be made perceptible and active in care practice...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28625599/disparities-in-anxiety-and-its-disorders
#7
EDITORIAL
Michael J Zvolensky, Lorra Garey, Jafar Bakhshaie
Much of the scientific work addressing the enigmas of anxiety and its disorders has been conducted among European Americans. This work has led to great progress into the nature of anxiety psychopathology, including etiologic, maintenance, and relapse processes. Moreover, evidenced-based treatments for anxiety and its disorders have arguably been among the best in the field of psychopathology for well over two decades. Yet, the progress thus far attained on the nature and treatment of anxiety disorders has not benefited all members of society equally...
May 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28622215/influence-of-gender-on-the-performance-of-cardiopulmonary-rescue-teams-a-randomized-prospective-simulator-study
#8
Simon Adrian Amacher, Cleo Schumacher, Corinne Legeret, Franziska Tschan, Norbert Karl Semmer, Stephan Marsch, Sabina Hunziker
OBJECTIVES: Little is known about the influence of gender on resuscitation performance which may improve future education in resuscitation. The aim of this study was to compare female and male rescuers in regard to cardiopulmonary resuscitation and leadership performance. DESIGN: Prospective, randomized simulator study. SETTING: High-fidelity patient simulator center of the medical ICU, University Hospitals Basel (Switzerland). SUBJECTS: Two hundred sixteen volunteer medical students (108 females and 108 males) of two Swiss universities in teams of three...
July 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28620741/a-potential-new-stable-state-of-the-e-cadherin-strand-swapped-dimer-in-solution
#9
Alexandra Schumann-Gillett, Alan E Mark, Evelyne Deplazes, Megan L O'Mara
E-cadherin is a transmembrane glycoprotein that facilitates inter-cellular adhesion in the epithelium. The ectodomain of the native structure is comprised of five repeated immunoglobulin-like domains. All E-cadherin crystal structures show the protein in one of three alternative conformations: a monomer, a strand-swapped trans homodimer and the so-called X-dimer, which is proposed to be a kinetic intermediate to forming the strand-swapped trans homodimer. However, previous studies have indicated that even once the trans strand-swapped dimer is formed, the complex is highly dynamic and the E-cadherin monomers may reorient relative to each other...
June 15, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28620036/substrate-selectivity-in-the-zdhhc-family-of-s-acyltransferases
#10
REVIEW
Kimon Lemonidis, Christine Salaun, Marianna Kouskou, Cinta Diez-Ardanuy, Luke H Chamberlain, Jennifer Greaves
S-acylation is a reversible lipid modification occurring on cysteine residues mediated by a family of membrane-bound 'zDHHC' enzymes. S-acylation predominantly results in anchoring of soluble proteins to membrane compartments or in the trafficking of membrane proteins to different compartments. Recent work has shown that although S-acylation of some proteins may involve very weak interactions with zDHHC enzymes, a pool of zDHHC enzymes exhibit strong and specific interactions with substrates, thereby recruiting them for S-acylation...
June 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28618845/evaluation-of-cognitive-and-social-functioning-in-patients-requiring-long-term-inpatient-psychiatric-care-using-the-international-classification-of-functioning-disability-and-health-a-large-scale-multi-institutional-observational-study
#11
Hideaki Kawaguchi, Masamoto Taguchi, Masune Sukigara, Shoji Sakuragi, Naoya Sugiyama, Hisomu Chiba, Tatsuhito Kawasaki
PURPOSE: We comprehensively evaluated cognitive and social functioning in patients requiring long-term inpatient psychiatric care using the International Classification of Functioning, Disability, and Health. METHOD: We surveyed 1967 patients receiving long-term inpatient psychiatric care. Patients were further categorized into an old long-stay group (n = 892, >5 years in hospitals) and a new long-stay group (n = 1075, 1-5 years in hospitals). We obtained responses for all the International Classification of Functioning, Disability, and Health items in domain b (Body Functions) and domain d (Activities and Participation)...
June 15, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28617854/choroidal-thickness-in-school-children-the-gobi-desert-children-eye-study
#12
Dan Zhu, Yan Wang, Yan Fei Zheng, Da Yong Yang, Kai Guo, Xian Rong Yang, Xin Xia Jing, Ian Y Wong, Qi Sheng You, Yong Tao, Jost B Jonas
PURPOSE: To investigate choroidal thickness (CT) and its associations in children in a school-based study. METHODS: The cross-sectional school-based Gobi Desert Children Eye Study included 1565 out of 1911 (81.9%) eligible children from all schools in the oasis region of Ejina in the Gobi Desert. A detailed ophthalmic examination was performed, including spectral-domain optical coherence tomography with enhanced depth imaging for CT measurement. RESULTS: CT measurements were available for 1463 (93...
2017: PloS One
https://www.readbyqxmd.com/read/28616191/towards-the-co-ordination-of-terrestrial-ecosystem-protocols-across-european-research-infrastructures
#13
Les G Firbank, Chiara Bertora, David Blankman, Gemini Delle Vedove, Mark Frenzel, Carlo Grignani, Elli Groner, Miklós Kertész, Eveline J Krab, Giorgio Matteucci, Christina Menta, Carsten W Mueller, Jutta Stadler, William E Kunin
The study of ecosystem processes over multiple scales of space and time is often best achieved using comparable data from multiple sites. Yet, long-term ecological observatories have often developed their own data collection protocols. Here, we address this problem by proposing a set of ecological protocols suitable for widespread adoption by the ecological community. Scientists from the European ecological research community prioritized terrestrial ecosystem parameters that could benefit from a more consistent approach to data collection within the resources available at most long-term ecological observatories...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28616001/development-and-validation-of-arabic-version-of-the-postoperative-quality-of-recovery-scale
#14
Abdullah Sulieman Terkawi, Siny Tsang, Waleed Riad, Sumaya Nemer Nassar, Maissa Mahmoud, Ghadah Jumaan AlKahtani, Hanin Hussain Alsharif, Khalid S Doais, Fatima Jaina Sala, Anas Abdulrahman, Colin F Royse
INTRODUCTION: The postoperative quality of recovery scale (PostopQRS) is a widely used tool to assess the postoperative quality of recovery. Our aim was to translate, culturally adapt, and validate the PostopQRS questionnaire in Arabic. METHODOLOGY: A systematic translation process was used to translate the original English PostopQRS into Arabic. After the pilot study, the translated version was validated among patients who underwent different types of surgeries...
May 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28614138/acute-exudative-paraneoplastic-polymorphous-vitelliform-maculopathy-during-vemurafenib-and-pembrolizumab-treatment-for-metastatic-melanoma
#15
Harpal S Sandhu, Anton M Kolomeyer, Marisa K Lau, Carol L Shields, Lynn M Schuchter, Charles W Nichols, Tomas S Aleman
PURPOSE: To describe a patient with BRAF mutation-positive cutaneous melanoma who developed acute exudative polymorphous vitelliform maculopathy during vemurafenib and pembrolizumab treatment for metastatic melanoma. METHODS: Retrospective case report documented with wide-field fundus imaging, spectral domain optical coherence tomography, and fundus autofluorescence imaging. RESULTS: A 55-year-old woman with bilateral ductal breast carcinoma and BRAF mutation-positive metastatic cutaneous melanoma complained of bilateral blurred vision within 5 days of starting vemurafenib (BRAF inhibitor)...
June 13, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28612361/fisr-activates-%C3%AF-54-dependent-transcription-of-sulfide-oxidizing-genes-in-cupriavidus-pinatubonensis-jmp134
#16
Huanjie Li, Juan Li, Chuanjuan Lü, Yongzhen Xia, Yufeng Xin, Honglei Liu, Luying Xun, Huaiwei Liu
Some heterotrophic bacteria are able to oxidize sulfide (H2 S, HS(-) , and S(2-) ) to sulfite and thiosulfate via polysulfide. The genes coding for the oxidation enzymes in Cupriavidus pinatubonensis JMP134 have recently been identified; however, their regulation is unknown. A regulator gene is adjacent to the operon of the sulfide-oxidizing genes, encoding a σ(54) -dependent transcription factor (FisR) with three domains: an R domain, an AAA+ domain, and a DNA-binding domain. We report here that the regulator responds to the presence of sulfide and activates the sulfide-oxidizing genes...
June 14, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28607953/a-tensegrity-model-for-hydrogen-bond-networks-in-proteins
#17
Robert P Bywater
Hydrogen-bonding networks in proteins considered as structural tensile elements are in balance separately from any other stabilising interactions that may be in operation. The hydrogen bond arrangement in the network is reminiscent of tensegrity structures in architecture and sculpture. Tensegrity has been discussed before in cells and tissues and in proteins. In contrast to previous work only hydrogen bonds are studied here. The other interactions within proteins are either much stronger - covalent bonds connecting the atoms in the molecular skeleton or weaker forces like the so-called hydrophobic interactions...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28602625/a-notch-independent-mechanism-contributes-to-the-induction-of-hes1-gene-expression-in-response-to-hypoxia-in-p19-cells
#18
Xiaofeng Zheng, Sampath Narayanan, Xiaowei Zheng, Sandra Luecke-Johansson, Katarina Gradin, Sergiu-Bogdan Catrina, Lorenz Poellinger, Teresa S Pereira
Hes1 is a Notch target gene that plays a major role during embryonic development. Previous studies have shown that HIF-1α can interact with the Notch intracellular domain and enhance Notch target gene expression. In this study, we have identified a Notch-independent mechanism that regulates the responsiveness of the Hes1 gene to hypoxia. Using P19 cells we show that silencing the Notch DNA binding partner CSL does not prevent hypoxia-dependent upregulation of Hes1 expression. In contrast to CSL, knockdown of HIF-1α or Arnt expression prevents Hes1 induction in hypoxia...
June 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28601710/evolution-of-word-meanings-through-metaphorical-mapping-systematicity-over-the-past-millennium
#19
Yang Xu, Barbara C Malt, Mahesh Srinivasan
One way that languages are able to communicate a potentially infinite set of ideas through a finite lexicon is by compressing emerging meanings into words, such that over time, individual words come to express multiple, related senses of meaning. We propose that overarching communicative and cognitive pressures have created systematic directionality in how new metaphorical senses have developed from existing word senses over the history of English. Given a large set of pairs of semantic domains, we used computational models to test which domains have been more commonly the starting points (source domains) and which the ending points (target domains) of metaphorical mappings over the past millennium...
June 8, 2017: Cognitive Psychology
https://www.readbyqxmd.com/read/28600906/giuseppe-sergi-the-portrait-of-a-positivist-scientist
#20
Giovanni Cerro
Giuseppe Sergi (1841-1936) was one of the most important anthropologists and psychologists of the age of positivism and this article focuses on three domains of his scientific research: degeneration, eugenics and race. His concept of degeneration is defined as the development of special forms of human adaptation to the environment. This issue is closely related to his theory of the "stratification of character", which had a profound impact on Italian psychiatry and criminal anthropology in the late nineteenth century...
June 9, 2017: Journal of Anthropological Sciences, Rivista di Antropologia: JASS
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