keyword
MENU ▼
Read by QxMD icon Read
search

Start domain

keyword
https://www.readbyqxmd.com/read/27906001/evolution-of-changes-in-cognitive-function-after-the-initiation-of-antiretroviral-therapy
#1
Borja Mora-Peris, Elizabeth Stevens, Francesca Ferretti, Jonathan Underwood, Stephen Taylor, Alan Winston
BACKGROUND: Cognitive function is reported to improve after the initiation of combination antiretroviral therapy (cART). Data on the evolution of such changes are limited. We assessed the dynamics of changes in cognitive parameters, in HIV-positive subjects initiating cART. METHODS: Cognitive function in seven domains was evaluated for HIV-infected patients without clinically significant cognitive impairment prior to the initiation of cART, and 24 and 48 weeks after...
April 14, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27903073/comparison-between-early-or-late-intravitreal-injection-of-dexamethasone-implant-in-branch-brvo-or-central-crvo-retinal-vein-occlusion-six-months-follow-up
#2
Fernanda Pacella, Giuseppe La Torre, Stefania Basili, Monica Autolitano, Antonella Pascarella, Tommaso Lenzi, Elena Pacella
PURPOSE: The purpose of this study was to compare early and late injections of intravitreal dexamethasone implant in patients affected by central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) with a six-month follow-up. We assessed whether an earlier treatment start (within 7 days from diagnosis) could be more beneficial than a delayed (or late) treatment start (after 7 days). MATERIALS AND METHODS: The study included 81 patients (81 eyes) affected by retinal vein occlusion...
November 30, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27902541/central-serous-chorioretinopathylike-mimicking-multifocal-vitelliform-macular-dystrophy-an-ocular-side-effect-of-mitogen-extracellular-signal-regulated-kinase-inhibitors
#3
Chiara Giuffrè, Elisabetta Miserocchi, Giulio Modorati, Adriano Carnevali, Alessandro Marchese, Lea Querques, Giuseppe Querques, Francesco Bandello
PURPOSE: To describe a case of multiple detachments of the neurosensory retina mimicking multifocal vitelliform macular dystrophy after chemotherapy with mitogen/extracellular signal-regulated kinase inhibitor for metastatic ovarian cancer. METHODS: Case report. RESULTS: A 38-year-old woman presented to our clinic for eye examination before the initiation of chemotherapy with trametinib. One month after starting treatment, the patient complained of vision loss and metamorphopsia in both eyes...
November 29, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27901589/the-human-adrenal-gland-proteome-defined-by-transcriptomics-and-antibody-based-profiling
#4
Julia Bergman, Johan Botling, Linn Fagerberg, Björn M Hallström, Dijana Djureinovic, Mathias Uhlén, Fredrik Pontén
The adrenal gland is a composite endocrine organ with vital functions that include the synthesis and release of glucocorticoids and catecholamines. To define the molecular landscape that underlies the specific functions of the adrenal gland, we combined a genome-wide transcriptomics approach based on mRNA sequencing of human tissues with immunohistochemistry-based protein profiling on tissue microarrays. Approximately two-thirds of all putative protein coding genes were expressed in the adrenal gland and the analysis identified 253 genes with an elevated pattern of expression in the adrenal gland, with only 37 genes showing a markedly higher expression level (>5-fold) in the adrenal gland compared to 31 other normal human tissue types analyzed...
November 30, 2016: Endocrinology
https://www.readbyqxmd.com/read/27899671/repeatsdb-2-0-improved-annotation-classification-search-and-visualization-of-repeat-protein-structures
#5
Lisanna Paladin, Layla Hirsh, Damiano Piovesan, Miguel A Andrade-Navarro, Andrey V Kajava, Silvio C E Tosatto
RepeatsDB 2.0 (URL: http://repeatsdb.bio.unipd.it/) is an update of the database of annotated tandem repeat protein structures. Repeat proteins are a widespread class of non-globular proteins carrying heterogeneous functions involved in several diseases. Here we provide a new version of RepeatsDB with an improved classification schema including high quality annotations for ∼5400 protein structures. RepeatsDB 2.0 features information on start and end positions for the repeat regions and units for all entries...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27896264/improving-fidelity-of-translation-of-the-stepping-on-falls-prevention-program-through-root-cause-analysis
#6
Jane E Mahoney, Vicki L Gobel, Terry Shea, Jodi Janczewski, Sandy Cech, Lindy Clemson
BACKGROUND: Fidelity monitoring is essential with implementation of complex health interventions, but there is little description of how to use results of fidelity monitoring to improve the draft program package prior to widespread dissemination. Root cause analysis (RCA) provides a systematic approach to identifying underlying causes and devising solutions to prevent errors in complex processes. Its use has not been described in implementation science. METHODS: Stepping On (SO) is a small group, community-based intervention that has been shown to reduce falls by 31%...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27895149/psychotherapy-for-adolescents-with-attention-deficit-hyperactivity-disorder-a-pediatrician-s-guide
#7
Vania Modesto-Lowe, Victoria Charbonneau, Pantea Farahmand
Attention-deficit hyperactivity disorder (ADHD) presents with high levels of inattention, impulsiveness, and hyperactivity. ADHD starts in childhood and results in impairments that continue into adulthood. ADHD symptoms lead to decreased functionality in various life domains and result in poor academics, behavioral challenges, delayed independence, and strained relationships. Despite advances in diagnosis and treatment, persistent residual symptoms are common, highlighting the need for novel treatment strategies...
November 27, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27891211/from-linked-open-data-to-molecular-interaction-studying-selectivity-trends-for-ligands-of-the-human-serotonin-and-dopamine-transporter
#8
Barbara Zdrazil, Eva Hellsberg, Michael Viereck, Gerhard F Ecker
Retrieval of congeneric and consistent SAR data sets for protein targets of interest is still a laborious task to do if no appropriate in-house data set is available. However, combining integrated open data sources (such as the Open PHACTS Discovery Platform) with workflow tools now offers the possibility of querying across multiple domains and tailoring the search to the given research question. Starting from two phylogenetically related protein targets of interest (the human serotonin and dopamine transporters), the whole chemical compound space was explored by implementing a scaffold-based clustering of compounds possessing biological measurements for both targets...
September 14, 2016: MedChemComm
https://www.readbyqxmd.com/read/27890459/relationship-of-systemic-cytokine-concentrations-to-cognitive-function-over-two-years-in-women-with-early-stage-breast-cancer
#9
Debra E Lyon, Ronald Cohen, Huaihou Chen, Debra L Kelly, Nancy L McCain, Angela Starkweather, Hyochol Ahn, Jamie Sturgill, Colleen K Jackson-Cook
: Cancer and its treatment are frequently associated with cancer-related cognitive impairment (CRCI). While CRCI has been associated with linked to chemotherapy, there is increasing evidence that the condition may start prior to treatment and for some, remain unresolved after active treatment and into survivorship. Although the pathophysiology of the condition is complex, alterations in systemic cytokines, signaling molecules activated in response to infection or injury that trigger inflammation, are a possible mechanism linked to cognitive dysfunction in breast cancer and other conditions...
November 13, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27889117/inadequate-pain-relief-among-patients-with-primary-knee-osteoarthritis
#10
Pedro A Laires, Jorge Laíns, Luís C Miranda, Rui Cernadas, Srini Rajagopalan, Stephanie D Taylor, José C Silva
BACKGROUND: Despite the widespread treatments for Osteoarthritis (OA), data on treatment patterns, adequacy of pain relief, and quality of life are limited. The prospective multinational Survey of Osteoarthritis Real World Therapies (SORT) was designed to investigate these aspects. OBJECTIVES: To analyze the characteristics and the patient reported outcomes of the Portuguese dataset of SORT at the start of observation. METHODS: Patients ≥ 50 years with primary knee OA who were receiving oral or topical analgesics were eligible...
October 28, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27886109/influence-of-secondary-structure-folding-on-the-mutually-exclusive-folding-process-of-gl5-i27-protein-evidence-from-molecular-dynamics-simulations
#11
Qing Wang, Yan Wang, Guangju Chen
Mutually exclusive folding proteins are a class of multidomain proteins in which the host domain remains folded while the guest domain is unfolded, and both domains achieve exchange of their folding status by a mutual exclusive folding (MEF) process. We carried out conventional and targeted molecular dynamics simulations for the mutually exclusive folding protein of GL5/I27 to address the MEF transition mechanisms. We constructed two starting models and two targeted models, i.e., the starting models GL5/I27-S and GL5/I27-ST in which the first model involves the host domain GL5 and the secondary-structure unfolded guest domain I27-S, while the second model involves the host domain GL5 and the secondary/tertiary-structure extending guest domain I27-ST, and the target models GL5-S/I27 and GL5-ST/I27 in which GL5-S and GL5-ST represent the secondary-structure unfolding and the secondary/tertiary-structure extending, respectively...
November 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27870978/towards-the-standardization-of-stem-cell-therapy-studies-for-ischemic-heart-diseases-bridging-the-gap-between-animal-models-and-the-clinical-setting
#12
REVIEW
Fábio Trindade, Adelino Leite-Moreira, João Ferreira-Martins, Rita Ferreira, Inês Falcão-Pires, Rui Vitorino
Today there is an increasing demand for heart transplantations for patients diagnosed with heart failure. Though, shortage of donors as well as the large number of ineligible patients hurdle such treatment option. This, in addition to the considerable number of transplant rejections, has driven the clinical research towards the field of regenerative medicine. Nonetheless, to date, several stem cell therapies tested in animal models fall by the wayside and when they meet the criteria to clinical trials, subjects often exhibit modest improvements...
November 14, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27870446/sex-gender-influences-on-the-nervous-system-basic-steps-toward-clinical-progress
#13
Claudette Elise Brooks, Janine Austin Clayton
A Commentary highlighting the progress that sex-based data and research have made in neuroscience and the complexities that research has revealed thus far. Basic and preclinical neuroscientific research that considers sex as a biological variable will continue to build on the foundation of knowledge that has been started by multiple predecessors. The expansion of knowledge in preclinical neuroscience that integrates the study of both sexes will have a significant role in informing clinical trial design. We applaud the efforts of the editors and authors who have contributed to this issue...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27870221/inductors-and-regulatory-properties-of-the-genomic-island-associated-fru2-metabolic-operon-of-streptococcus-agalactiae
#14
Kévin Patron, Philippe Gilot, Vanessa Rong, Aurélia Hiron, Laurent Mereghetti, Emilie Camiade
The fru2 metabolic operon of Streptococcus agalactiae encodes the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) enzyme II complex Fru2 (EIIB(Fru2) , EIIA(Fru2) , and EIIC(Fru2) ); Fru2 R, a transcriptional activator with PTS regulatory domains (PRDs); a D-allulose-6-phosphate 3-epimerase; a transaldolase; and a transketolase. We showed that the transcription of fru2 is induced during the stationary phase of growth in complex media and during incubation in human cerebrospinal or amniotic fluids...
November 21, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27867790/magma-injection-into-a-long-lived-reservoir-to-explain-geodetically-measured-uplift-application-to-the-2007-2014-unrest-episode-at-laguna-del-maule-volcanic-field-chile
#15
Hélène Le Mével, Patricia M Gregg, Kurt L Feigl
Moving beyond the widely used kinematic models for the deformation sources, we present a new dynamic model to describe the process of injecting magma into an existing magma reservoir. To validate this model, we derive an analytical solution and compare its results to those calculated using the Finite Element Method. A Newtonian fluid characterized by its viscosity, density, and overpressure (relative to the lithostatic value) flows through a vertical conduit, intruding into a reservoir embedded in an elastic domain, leading to an increase in reservoir pressure and time-dependent surface deformation...
August 2016: Journal of Geophysical Research. Solid Earth
https://www.readbyqxmd.com/read/27864380/setd5-is-essential-for-mammalian-development-and-co-transcriptional-regulation-of-histone-acetylation
#16
Anna B Osipovich, Rama Gangula, Pedro G Vianna, Mark A Magnuson
SET-domain containing proteins play a vital role in regulating gene expression during development through modifications in chromatin structure. Here we show that SET domain containing 5 (Setd5) is divergently transcribed with Gt(ROSA26)Sor, is necessary for mammalian development, and interacts with the PAF1 co-transcriptional complex and other proteins. Setd5-deficient embryos exhibit severe defects in neural tube formation, somitogenesis, and cardiac development, have aberrant vasculogenesis in embryos, yolk sacs, and placentas; and die between embryonic day 10...
November 18, 2016: Development
https://www.readbyqxmd.com/read/27863093/potential-effect-of-mechano-growth-factor-e-domain-peptide-on-axonal-guidance-growth-in-primary-cultured-cortical-neurons-of-rats
#17
Meili Liu, Xufeng Niu, Gang Zhou, Zhengtai Jia, Ping Li, Yubo Fan
Establishing appropriate synaptic connections and plasticity is a critical need in neuronal regeneration and development. Mechano growth factor (MGF) and its C-terminal E-domain peptide with 24 amino acids, MGF-Ct24E, are potential neuroprotective agents. Our preliminary study indicates that Netrin-1 can guide axonal growth and its expression is sensitive to MGF, but how MGF regulates the expression of Netrin-1 and its receptor DCC is still unclear. Here, we investigate the effect of MGF-Ct24E on the expression of Netrin-1 and DCC in primary cultured cortical neurons in vitro and the adult rat brain in vivo...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27860107/quantitative-method-to-investigate-the-balance-between-metabolism-and-proteome-biomass-starting-from-glycine
#18
Haiwei Gu, Patrick A Carroll, Jianhai Du, Jiangjiang Zhu, Fausto Carnevale Neto, Robert N Eisenman, Daniel Raftery
The balance between metabolism and biomass is very important in biological systems; however, to date there has been no quantitative method to characterize the balance. In this methodological study, we propose to use the distribution of amino acids in different domains to investigate this balance. It is well known that endogenous or exogenous amino acids in a biological system are either metabolized or incorporated into free amino acids (FAAs) or proteome amino acids (PAAs). Using glycine (Gly) as an example, we demonstrate a novel method to accurately determine the amounts of amino acids in various domains using serum, urine, and cell samples...
November 15, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27859304/from-mfd-to-trcf-and-back-again-a-perspective-on-bacterial-transcription-coupled-nucleotide-excision-repair
#19
Alexandra M Deaconescu, Margaret M Suhanovsky
Photochemical and other reactions on DNA cause damage and corrupt genetic information. To counteract this damage, organisms have evolved intricate repair mechanisms that often crosstalk with other DNA-based processes, such as transcription. Intriguing observations in the late 1980s and early 1990s led to the discovery of transcription-coupled repair (TCR), a subpathway of nucleotide excision repair (NER). TCR, found in all domains of life prioritizes for repair lesions located in the transcribed DNA strand, directly read by RNA polymerase...
November 12, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27856379/templates-as-a-method-for-implementing-data-provenance-in-decision-support-systems
#20
Vasa Curcin, Elliot Fairweather, Roxana Danger, Derek Corrigan
Decision support systems are used as a method of promoting consistent guideline-based diagnosis supporting clinical reasoning at point of care. However, despite the availability of numerous commercial products, the wider acceptance of these systems has been hampered by concerns about diagnostic performance and a perceived lack of transparency in the process of generating clinical recommendations. This resonates with the Learning Health System paradigm that promotes data-driven medicine relying on routine data capture and transformation, which also stresses the need for trust in an evidence-based system...
November 14, 2016: Journal of Biomedical Informatics
keyword
keyword
84940
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"