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Intrauterine growth restriction

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https://www.readbyqxmd.com/read/29452236/cardiac-and-placental-mitochondrial-characterization-in-a-rabbit-model-of-intrauterine-growth-restriction
#1
M Guitart-Mampel, A Gonzalez-Tendero, S Niñerola, C Morén, M Catalán-Garcia, I González-Casacuberta, D L Juárez-Flores, O Ugarteburu, L Matalonga, M V Cascajo, F Tort, A Cortés, E Tobias, J C Milisenda, J M Grau, F Crispi, E Gratacós, G Garrabou, F Cardellach
BACKGROUND: Intrauterine growth restriction (IUGR) is associated with cardiovascular remodeling persisting into adulthood. Mitochondrial bioenergetics, essential for embryonic development and cardiovascular function, are regulated by nuclear effectors as sirtuins. A rabbit model of IUGR and cardiovascular remodeling was generated, in which heart mitochondrial alterations were observed by microscopic and transcriptomic analysis. We aimed to evaluate if such alterations are translated at a functional mitochondrial level to establish the etiopathology and potential therapeutic targets for this obstetric complication...
February 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29447718/no-240-cytomegalovirus-infection-in-pregnancy
#2
Yoav Yinon, Dan Farine, Mark H Yudin
OBJECTIVES: To review the principles of prenatal diagnosis of congenital cytomegalovirus (CMV) infection and to describe the outcomes of the affected pregnancies. OUTCOMES: Effective management of fetal infection following primary and secondary maternal CMV infection during pregnancy. Neonatal signs include intrauterine growth restriction (IUGR), microcephaly, hepatosplenomegaly, petechiae, jaundice, chorioretinitis, thrombocytopenia and anemia, and long-term sequelae consist of sensorineural hearing loss, mental retardation, delay of psychomotor development, and visual impairment...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29436718/fetal-doppler-changes-one-week-after-endoscopic-equatorial-laser-for-twin-to-twin-transfusion-syndrome-a-longitudinal-study
#3
Nicola Persico, Francesco D'Ambrosi, Isabella Fabietti, Simona Boito, Elisa Aiello, Alessandro Bulfoni, Fabrizio Ciralli, Alessandra Kustermann, Fabio Mosca, Luigi Fedele
OBJECTIVE: To investigate sequential Doppler changes in donors and recipients before and one week after endoscopic laser for twin-to-twin transfusion syndrome (TTTS) and to examine factors that may be associated with such changes. METHODS: In TTTS pregnancies undergoing laser treatment, we examined fetal Doppler changes before and one week post-intervention. Intrauterine death rates and preoperative factors were analysed in relation to Doppler changes. RESULTS: Among 129 (85...
February 13, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29436080/fetoscopic-laser-photocoagulation-for-twin-twin-transfusion-syndrome
#4
Haruhiko Sago, Keisuke Ishii, Rika Sugibayashi, Katsusuke Ozawa, Masahiro Sumie, Seiji Wada
The aim of this study was to review fetoscopic laser photocoagulation (FLP), which ablates placental vascular anastomoses to treat twin-twin transfusion syndrome (TTTS). A review of studies reporting on the procedures, outcomes, complications and nonconventional applications of FLP for TTTS was conducted. FLP has been established as the primary treatment for monochorionic twin pregnancy associated with TTTS at 16-26 weeks. FLP is the only therapy that directly addresses the underlying pathophysiology. The recent technique modification of FLP, referred to as the 'Solomon technique', induces selective coagulation to connect the anastomoses ablation sites and has been introduced to reduce residual anastomoses...
February 13, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29434026/identification-of-early-indicators-of-altered-metabolism-in-normal-development-using-a-rodent-model-system
#5
Ashok Daniel Prabakaran, Jimsheena Valiyakath Karakkat, Ranjit Vijayan, Jisha Chalissery, Marwa F Ibrahim, Suneesh Kaimala, Ernest A Adeghate, Ahmed Hasan Al-Marzouqi, Suraiya Anjum Ansari, Mensah-Brown Epk, Bright Starling Emerald
Although the existence of a close relationship between the early maternal developmental environment, fetal size at birth and the risk of developing disease in adulthood has been suggested, most studies, however, employed experimentally induced intrauterine growth restriction as model to link this with later adult disease. Since embryonic size variation occurs under normal growth and differentataion as well, elucidating the molecular mechanisms underlying these changes and their relevance to later adult disease risk becomes important...
January 30, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29432217/prematurity-and-future-kidney-health-the-growing-risk-of-chronic-kidney-disease
#6
Michelle C Starr, Sangeeta R Hingorani
PURPOSE OF REVIEW: The purpose of this review is to describe the role prematurity plays in the development of chronic kidney disease (CKD) and to discuss potential reasons for this association including decreased nephron mass, as well as postnatal insults such as neonatal acute kidney injury (nAKI). RECENT FINDINGS: New observational studies in humans and experimental studies in animal models have strengthened the association between prematurity, low birth weight and CKD...
February 9, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29425713/the-effect-of-oxidative-stress-induced-by-tert-butylhydroperoxide-under-distinct-folic-acid-conditions-an-in-vitro-study-using-cultured-human-trophoblast-derived-cells
#7
Jaqueline Vieira Carletti, Ana Correia-Branco, Claudia Raquel Silva, Nelson Andrade, Lenir Orlandi Pereira Silva, Fátima Martel
Preeclampsia is a pregnancy disorder characterized by maternal blood pressure, fetal growth restriction and intrauterine hypoxia. Folic acid is a vitamin required during pregnancy. In this work, we investigated the relationship between preeclampsia and the intake of distinct doses of folic acid during pregnancy. Considering that preeclampsia is associated with increased placental oxidative stress levels, we investigated the effect of oxidative stress induced by tert-butylhydroperoxide (TBH) in human trophoblast-derived cells cultured upon deficient/low, physiological and supra-physiological folic acid levels...
February 6, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29423971/two-de-novo-novel-mutations-in-one-shank3-allele-in-a-patient-with-autism-and-moderate-intellectual-disability
#8
Wenmiao Zhu, Jianli Li, Stella Chen, Jinglan Zhang, Francesco Vetrini, Alicia Braxton, Christine M Eng, Yaping Yang, Fan Xia, Kory L Keller, Leila Okinaka-Hu, Chung Lee, J Lloyd Holder, Weimin Bi
SHANK3 encodes for a scaffolding protein that links neurotransmitter receptors to the cytoskeleton and is enriched in postsynaptic densities of excitatory synapses. Deletions or mutations in one copy of the SHANK3 gene cause Phelan-McDermid syndrome, also called 22q13.3 deletion syndrome, a neurodevelopmental disorder with common features including global developmental delay, absent to severely impaired language, autistic behavior, and minor dysmorphic features. By whole exome sequencing, we identified two de novo novel variants including one frameshift pathogenic variant and one missense variant of unknown significance in a 14-year-old boy with delayed motor milestones, delayed language acquisition, autism, intellectual disability, ataxia, progressively worsening spasticity of the lower extremities, dysmorphic features, short stature, microcephaly, failure to thrive, chronic constipation, intrauterine growth restriction, and bilateral inguinal hernias...
February 9, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29423394/a-program-for-weaning-children-from-enteral-feeding-in-a-general-pediatric-unit-how-for-whom-and-with-what-results
#9
Justine Mirete, Béatrice Thouvenin, Gaelle Malecot, Morgane Le-Gouëz, Christel Chalouhi, Catherine du Fraysseix, Aurélie Royer, Anais Leon, Clément Vachey, Véronique Abadie
Objective: To describe a series of children who were hospitalized for a tube-weaning program in the general pediatric ward of a pediatric tertiary university hospital: describe our method, to determine the success rate of our inpatient pediatric tube weaning program, and search for relevant factors linked to its success or failure. Method: We analyzed the medical files of consecutive children who were hospitalized for gastric-tube weaning over an 8-year period. We analyzed outcomes in terms of feeding and growth with at least 2 years of data...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29422213/antenatal-glucocorticoids-magnesium-sulfate-and-mode-of-birth-in-preterm-fetal-small-for-gestational-age
#10
REVIEW
Joseph Y Ting, John C Kingdom, Prakesh S Shah
A diagnosis of fetal growth restriction and subsequent preterm birth is associated with increased risks of adverse perinatal and neurodevelopmental outcomes and potentially long-lasting effects to adulthood. Most such cases are associated with placental insufficiency and the fetal response to chronic intrauterine hypoxemia and nutrient deprivation leads to substantial physiological and metabolic adaptations. The management of such pregnancies, especially with respect to perinatal interventions and birth mode, remains an unresolved dilemma...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29422211/outcome-in-early-onset-fetal-growth-restriction-is%C3%A2-best-combining-computerized-fetal-heart-rate-analysis-with-ductus-venosus-doppler-insights-from-the-trial-of-umbilical-and-fetal-flow-in-europe
#11
REVIEW
Tiziana Frusca, Tullia Todros, Christoph Lees, Caterina M Bilardo
BACKGROUND: Early-onset fetal growth restriction represents a particular dilemma in clinical management balancing the risk of iatrogenic prematurity with waiting for the fetus to gain more maturity, while being exposed to the risk of intrauterine death or the sequelae of acidosis. OBJECTIVE: The Trial of Umbilical and Fetal Flow in Europe was a European, multicenter, randomized trial aimed to determine according to which criteria delivery should be triggered in early fetal growth restriction...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29416108/combination-of-serum-histidine-rich-glycoprotein-and-uterine-artery-doppler-to-predict-preeclampsia
#12
Adisorn Aksornphusitaphong, Vorapong Phupong
The primary aim of this study is to determine the value of using a combination of serum histidine-rich glycoprotein (HRG) level and uterine artery pulsatility index (PI) in pregnant women at 11-13+6 weeks' gestation to predict preeclampsia. The secondary aim is to determine the association between other pregnancy complications with the use of these combined tests. Transabdominal uterine artery PI and serum HRG level were measured at the time of first-trimester aneuploidy screening at 11-13+6 weeks' gestation in 327 pregnant women...
February 7, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29413487/maternal-protein-restriction-during-lactation-induces-early-and-lasting-plasma-metabolomic-and-hepatic-lipidomic-signatures-of-the-offspring-in-a-rodent-programming-model
#13
Aurore Martin Agnoux, Angélina El Ghaziri, Thomas Moyon, Anthony Pagniez, Agnès David, Gilles Simard, Patricia Parnet, El Mostafa Qannari, Dominique Darmaun, Jean-Philippe Antignac, Marie-Cécile Alexandre-Gouabau
Perinatal undernutrition affects not only fetal and neonatal growth but also adult health outcome, as suggested by the metabolic imprinting concept. However, the exact mechanisms underlying offspring metabolic adaptations are not yet fully understood. Specifically, it remains unclear whether the gestation or the lactation is the more vulnerable period to modify offspring metabolic flexibility. We investigated in a rodent model of intrauterine growth restriction (IUGR) induced by maternal protein restriction (R) during gestation which time window of maternal undernutrition (gestation, lactation or gestation-lactation) has more impact on the male offspring metabolomics phenotype...
December 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29413485/perinatal-supplementation-of-4-phenylbutyrate-and-glutamine-attenuates-endoplasmic-reticulum-stress-and-improves-colonic-epithelial-barrier-function-in-rats-born-with-intrauterine-growth-restriction
#14
Axel Désir-Vigné, Vianney Haure-Mirande, Pierre de Coppet, Dominique Darmaun, Gwenola Le Dréan, Jean-Pierre Segain
Intrauterine growth restriction (IUGR) can affect the structure and function of the intestinal barrier and increase digestive disease risk in adulthood. Using the rat model of maternal dietary protein restriction (8% vs. 20%), we found that the colon of IUGR offspring displayed decreased mRNA expression of epithelial barrier proteins MUC2 and occludin during development. This was associated with increased mRNA expression of endoplasmic reticulum (ER) stress marker XBP1s and increased colonic permeability measured in Ussing chambers...
December 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29411344/maternal-and-perinatal-outcomes-of-dichorionic-diamniotic-twin-pregnancies-diagnosed-with-vanishing-twin-syndrome-a-retrospective-analysis-from-a-single-clinical-center
#15
Hakan Timur, Rifat Taner Aksoy, Aytekin Tokmak, Burcu Timur, Bugra Coskun, Dilek Uygur, Nuri Danisman
OBJECTIVES: Multiple pregnancies are known to be associated with adverse maternal and perinatal complications. How-ever, data regarding the outcomes of spontaneously reduced twin pregnancies are limited. In the current study we aimed to evaluate the consequences of the vanishing twin syndrome (VTS) in dichorionic diamniotic twin pregnancies for both mother and baby in our perinatal center. MATERIAL AND METHODS: A total of 711 pregnancies were included into the study...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29408800/body-composition-in-preterm-infants-with-intrauterine-growth-restriction-a-cohort-study
#16
Letícia Duarte Villela, Maria Dalva Barbosa Baker Méio, Saint Clair S Gomes Junior, Andrea Dunshee de Abranches, Fernanda Valente Mendes Soares, Maria Elisabeth Lopes Moreira
AIMS: The comparison of body composition parameters between the small for gestational age (SGA) and appropriate for gestational age (AGA) at term, 1, 3 and 5 months corrected ages in very preterm infants. METHODS: This cohort study included 92 preterm infants at term age, younger than 32 weeks or <1500 g, classified in two groups: SGA and AGA. Anthropometry and body composition, estimated by air displacement plethysmography, were evaluated at the corrected ages: term and 1, 3, and 5 months...
February 6, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29405972/combination-of-first-trimester-serum-afamin-levels-and-three-dimensional-placental-bed-vascularization-as-a-possible-screening-method-to-detect-women-at-risk-for-adverse-pregnancy-complications-like-pre-eclampsia-and-gestational-diabetes-mellitus-in-low-risk
#17
Allessandra Tramontana, Eleonore Pablik, Gerhard Stangl, Beda Hartmann, Hans Dieplinger, Erich Hafner
OBJECTIVE: Aim of the study was to assess the correlation of first trimester serum afamin levels with three-dimensional placental bed vascularization in pregnant women and its prognostic value for predicting pre-eclampsia and future fetal and maternal complications during pregnancy. METHODS: In this nested case-control study all pregnant women registered for delivery during a period of 3 years were routinely screened in the first trimester. Serum afamin levels were assessed in 764 women and correlated to 5 pregnancy outcome groups: gestational hypertension (n = 76), pre-eclampsia (n = 33), intrauterine growth restriction (n = 91), pre-term birth (n = 39), gestational diabetes mellitus (n = 170); In addition, measurements of first trimester myometrial vascularization index were performed and, in combination with afamin tested as a possible screening method to detect women at-risk for the development of adverse complications in low-risk pregnancies at the time of the first trimester...
February 2018: Placenta
https://www.readbyqxmd.com/read/29402148/urinary-tract-infection-during-pregnancy-current-concepts-on-a-common-multifaceted-problem
#18
Kallirhoe Kalinderi, Dimitrios Delkos, Michail Kalinderis, Apostolos Athanasiadis, Ioannis Kalogiannidis
Urinary tract infections (UTIs) are the most common bacterial infection in pregnancy, increasing the risk of maternal and neonatal morbidity and mortality. Urinary tract infections may present as asymptomatic bacteriuria, acute cystitis or pyelonephritis. Escherichia coli is the most common pathogen associated with both symptomatic and asymptomatic bacteriuria. If asymptomatic bacteriuria is untreated, up to 30% of mothers develop acute pyelonephritis, with an increased risk of multiple maternal and neonatal complications, such as preeclampsia, preterm birth, intrauterine growth restriction and low birth weight...
February 6, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29398400/micrornas-link-chronic-inflammation-in-childhood-to-growth-impairment-and-insulin-resistance
#19
REVIEW
Francesca Cirillo, Pietro Lazzeroni, Cecilia Catellani, Chiara Sartori, Sergio Amarri, Maria Elisabeth Street
MicroRNAs are involved in multiple pathophysiological networks and in the pathogenesis of a broad spectrum of human disorders, including cancer and inflammatory diseases. Impaired linear growth is encountered in children with chronic inflammatory conditions such as cystic fibrosis, inflammatory bowel diseases, juvenile idiopathic arthritis, celiac disease and in subjects born intrauterine growth restricted/small for gestational age. Children with inflammatory conditions may also be at risk of developing insulin resistance as a result of the inflammatory process and concurrent therapy...
February 2, 2018: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29397052/intrauterine-growth-restriction-combined-with-a-maternal-high-fat-diet-increased-adiposity-and-serum-corticosterone-levels-in-adult-rat-offspring
#20
E K Zinkhan, B Yu, C W Callaway, R A McKnight
Intrauterine growth restriction (IUGR) and fetal exposure to a maternal high-fat diet (HFD) independently increase the risk of developing obesity in adulthood. Excess glucocorticoids increase obesity. We hypothesized that surgically induced IUGR combined with an HFD would increase adiposity and glucocorticoids more than in non-IUGR offspring combined with the same HFD, findings that would persist despite weaning to a regular diet. Non-IUGR (N) and IUGR (I) rat offspring from dams fed either regular rat chow (R) or an HFD (H) were weaned to either a regular rat chow or an HFD...
February 5, 2018: Journal of Developmental Origins of Health and Disease
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