keyword
MENU ▼
Read by QxMD icon Read
search

Intrauterine growth restriction

keyword
https://www.readbyqxmd.com/read/29691766/characterization-of-the-hemodynamic-wall-shear-stresses-in-human-umbilical-vessels-from-normal-and-intrauterine-growth-restricted-pregnancies
#1
Shier Nee Saw, Yu Wei Poh, Dawn Chia, Arijit Biswas, Citra Nurfarah Zaini Mattar, Choon Hwai Yap
Significant reductions in blood flow and umbilical diameters were reported in pregnancies affected by intrauterine growth restriction (IUGR) from placental insufficiency. However, it is not known if IUGR umbilical blood vessels experience different hemodynamic wall shear stresses (WSS) compared to normal umbilical vessels. As WSS is known to influence vasoactivity and vascular growth and remodeling, which can regulate flow rates, it is important to study this parameter. In this study, we aim to characterize umbilical vascular WSS environment in normal and IUGR pregnancies, and evaluate correlation between WSS and vascular diameter, and gestational age...
April 24, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29686379/maternal-early-pregnancy-obesity-and-related-pregnancy-and-pre-pregnancy-disorders-associations-with-child-developmental-milestones-in-the-prospective-predo-study
#2
Polina Girchenko, Soile Tuovinen, Marius Lahti-Pulkkinen, Jari Lahti, Katri Savolainen, Kati Heinonen, Riikka Pyhälä, Rebecca M Reynolds, Esa Hämäläinen, Pia M Villa, Eero Kajantie, Anu-Katriina Pesonen, Hannele Laivuori, Katri Räikkönen
BACKGROUND/OBJECTIVES: Previous studies have linked maternal pre-pregnancy obesity (BMI ≥30 kg/m2 ) with suboptimal neurodevelopment in her offspring; however, the literature is not entirely consistent. Whether these effects are muddled by maternal self-reports of pre-pregnancy weight and height, or are driven or amplified by the well often comorbid hypertensive and diabetic pregnancy and pre-pregnancy disorders, remains unclear. We examined whether maternal early pregnancy obesity is associated with developmental delay in her offspring, and if the associations are driven or amplified by diabetic and hypertensive pregnancy and pre-pregnancy disorders...
April 23, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29686285/novel-plasma-proteins-in-nepalese-school-aged-children-are-associated-with-a-small-head-size-at-birth
#3
Sun Eun Lee, Keith P West, Robert N Cole, Kerry J Schulze, Lee S-F Wu, James D Yager, John Groopman, Parul Christian
Fetal growth restriction increases the risk of poor childhood growth and development and chronic disease in adulthood. Yet, little is known about biological pathways that mediate the long-lasting effects of suboptimal intrauterine growth. We explored the plasma proteome in a cohort of 500 Nepalese children 6-8 years of age to identify plasma proteins associated with multiple anthropometric size indicators at birth. Among 982 proteins analyzed, no proteins differed by birth weight, length, or weight-for-length indicators...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29685622/early-dietary-restriction-in-rats-alters-skeletal-muscle-tuberous-sclerosis-complex-ribosomal-s6-and-mitogen-activated-protein-kinase
#4
Kara L Calkins, Shanthie Thamotharan, Yun Dai, Bo-Chul Shin, Satish C Kalhan, Sherin U Devaskar
Intrauterine growth restriction is linked to decreased lean body mass and insulin resistance. The mammalian target of rapamycin (mTOR) regulates muscle mass and glucose metabolism; however, little is known about maternal dietary restriction and skeletal muscle mTOR in offspring. We hypothesized that early dietary restriction would decrease skeletal muscle mass and mTOR in the suckling rat. To test this hypothesis, ab libitum access to food or dietary restriction during gestation followed by postnatal cross-fostering to a dietary-restricted or ad libitum-fed rat dam during lactation generated 4 groups: control (CON), intrauterine dietary restricted (IUDR), postnatal dietary restricted (PNDR), and IUDR+PNDR (IPDR)...
March 23, 2018: Nutrition Research
https://www.readbyqxmd.com/read/29685073/the-association-of-second-trimester-biomarkers-in-amniotic-fluid-and-fetal-outcome
#5
Irene Sterpu, Peter Anfelter, Susan Wray, Helena Kaihola, Helena Åkerud, Eva Wiberg-Itzel
OBJECTIVE: To identify the level of amniotic fluid lactate (AFL), placental growth factor (PLGF) and vascular endothelial growth factor (VEGF) at second trimester amniocentesis, and to compare levels in normal pregnancies with pregnancies ending in a miscarriage, an intrauterine growth restricted fetus (IUGR) or decreased fetal movements. STUDY DESIGN: A prospective cohort study. Amniotic fluid was consecutive collected at amniocentesis in 106 pregnancies. Fetal wellbeing at delivery was evaluated from medical files and compared with the levels of AFL, VEGF and PLGF at the time of amniocentesis...
April 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29681506/the-effect-of-very-advanced-maternal-age-on-maternal-and-neonatal-outcomes-a-systematic-review
#6
Jordana Leader, Amrit Bajwa, Andrea Lanes, Xiaolin Hua, Ruth Rennicks White, Natalie Rybak, Mark Walker
OBJECTIVE: To summarize information on the maternal and perinatal outcomes among pregnant women with a maternal age greater or equal to 45 years old compared with women with a maternal age of less than 45. METHODS: A comprehensive systematic search of online databases from January 1946 through June 2015 was completed. The maternal outcomes were: fetal loss, preterm birth, full-term birth, complications of pregnancy, the type of delivery, and periconception hemorrhage...
April 19, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29680191/-cost-of-hypertrophy-due-to-intrauterine-growth-restriction-attributable-to-air-pollution-in-france
#7
C Rafenberg, I Annesi-Maesano
Exposure of pregnant women to fine particulate matter<2.5μm in diameter (PM2.5 ) is responsible for low birthweight (LBW) and intellectual disabilities, as expressed by a lower intelligence quotient (IQ). We estimated the attributable cost due to PM2.5 of healthcare at birth and cognitive retardation of children with LBW in metropolitan France in 2012. The cost of specific care of the 8300 (range, 3100-13,300) children born every year in France with a LBW attributable to PM2.5 exposure is estimated at €25 million (range, € 9...
April 18, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29675904/risk-factors-for-fetal-death-after-radiofrequency-ablation-for-complicated-monochorionic-twin-pregnancies
#8
Luming Sun, Gang Zou, Yingjun Yang, Fenhe Zhou, Duan Tao
OBJECTIVE: Radiofrequency ablation (RFA) is a management alternative for complicated monochorionic twin pregnancies. The purpose of this study is to evaluate risk factors for fetal death after RFA. METHODS: An observational study was performed to document the perinatal outcomes of all cases undergoing fetal reduction using RFA from 2010 to 2016 at the Shanghai First Maternity and Infant Hospital. A multiple regression model was built to identify predictors of the death of the remaining fetus after RFA...
April 19, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29674192/predictive-value-of-sflt-1-plgf-sflt-1-plgf-ratio-and-papp-a-for-late-onset-preeclampsia-and-iugr-between-32-and-37-weeks-of-pregnancy
#9
C Birdir, L Droste, L Fox, M Frank, J Fryze, A Enekwe, A Köninger, R Kimmig, B Schmidt, A Gellhaus
OBJECTIVES: The aim of this study was to investigate, whether maternal serum levels of sFlt-1, PlGF and PAPP-A at third trimester of pregnancy are associated with late-onset PE and intrauterine growth retardation (IUGR) after 34 weeks of pregnancy. METHODS: This was a prospective study measuring the maternal serum levels of soluble tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) at 32-37 weeks of pregnancy: 730 patients were enrolled and 676 had neither intrauterine growth restriction (IUGR) nor preeclampsia (PE) or pregnancy induced hypertension (PIH) throughout the pregnancy...
April 11, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29667739/maternal-depressive-symptoms-during-and-after-pregnancy-and-child-developmental-milestones
#10
Soile Tuovinen, Marius Lahti-Pulkkinen, Polina Girchenko, Jari Lipsanen, Jari Lahti, Kati Heinonen, Rebecca M Reynolds, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Anu-Katriina Pesonen, Pia M Villa, Katri Räikkönen
BACKGROUND: Maternal depressive symptoms during and after pregnancy predict poorer child neurodevelopment. The effects of timing, symptom severity, and additive influences remain unclear. METHODS: A total of 2,231 mothers of the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiological Studies Depression Scale biweekly up to 14 times during pregnancy and twice up to 12 months after pregnancy...
April 18, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29664552/importance-of-polymorphic-variants-of-tumour-necrosis-factor-%C3%AE-gene-in-the-etiology-of-intrauterine-growth-restriction
#11
Agnieszka Kaluba-Skotarczak, Justyna Magiełda, Anna Romała, Grażyna Kurzawińska, Magdalena Barlik, Krzysztof Drews, Marcin Ożarowski, Tomasz Łoziński, Agnieszka Seremak-Mrozikiewicz
OBJECTIVES: Intrauterine growth restriction (IUGR) is one of the main global causes of increased perinatal mortality and fetal and neonatal morbidity. It remains a key challenge for modern perinatal medicine. Negative effects of IUGR are manifested not only in the perinatal period but also at the later stages of life. Proinflammatory cytokines and their polymorphisms are hypothesized to play an important role in IUGR pathomechanisms. The aim of the study was to determine the role of selected polymorphisms (-238G >A, -308G >A and -376G >A) of tumor necrosis factor alpha (TNF-α) in the etiology of intrauterine growth restriction...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29664498/-hypophosphatemia-in-preterm-infants-a-bimodal-disorder
#12
María Paz Cubillos Celis, Patricia Mena Nannig
New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29661800/chorionic-somatomammotropin-impacts-early-fetal-growth-and-placental-gene-expression
#13
Kimberly M Jeckel, Alexander C Boyarko, Gerrit Bouma, Quinton Winger, Russ V Anthony
Several developmental windows, including placentation, must be negotiated to establish and maintain pregnancy. Impaired placental function can lead to pre-eclampsia and/or intrauterine growth restriction (IUGR), resulting in increased infant mortality and morbidity. It has been hypothesized that chorionic somatomammotropin (CSH), plays a significant role in fetal development, potentially by modifying maternal and fetal metabolism. Recently, using lentiviral-mediated in vivo RNA interference in sheep, we demonstrated significant reductions in near-term (135 days of gestation; dGA) fetal and placental size, and altered fetal liver gene expression, resulting from CSH deficiency...
April 16, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29659962/low-dietary-folate-interacts-with-mthfd1-synthetase-deficiency-in-mice-a-model-for-the-r653q-variant-to-increase-incidence-of-developmental-delays-and-defects
#14
Karen E Christensen, Renata H Bahous, Wenyang Hou, Liyuan Deng, Olga V Malysheva, Erland Arning, Teodoro Bottiglieri, Marie A Caudill, Loydie A Jerome-Majewska, Rima Rozen
Background: Suboptimal folate intake, a risk factor for birth defects, is common even in areas with folate fortification. A polymorphism in methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), R653Q (MTHFD1 c.1958 G > A), has also been associated with increased birth defect risk, likely through reduced purine synthesis. Objective: We aimed to determine if the interaction of MTHFD1 synthetase deficiency and low folate intake increases developmental abnormalities in a mouse model for MTHFD1 R653Q...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29659033/gna11-differentially-mediates-fgf2-and-vegfa-induced-cellular-responses-in-human-fetoplacental-endothelial-cells
#15
Qing-Yun Zou, Ying-Jie Zhao, Hua Li, Xiang-Zhen Wang, Ai-Xia Liu, Xin-Qi Zhong, Qin Yan, Yan Li, Chi Zhou, Jing Zheng
During pregnancy, fetoplacental angiogenesis is dramatically increased in association with rapidly elevated blood flows. Any disruption of fetoplacental angiogenesis may lead to pregnancy complications such as intrauterine growth restriction. Fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) are crucial regulators of fetoplacental angiogenesis. G protein α subunits q (GNAq) and 11 (GNA11), two members of Gαq/11 subfamily are involved in mediating vascular growth and basal blood pressure...
April 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29630011/a-comparison-of-methods-for-the-diagnosis-of-fetal-growth-restriction-between-the-royal-college-of-obstetricians-and-gynaecologists-and-the-american-college-of-obstetricians-and-gynecologists
#16
Nathan R Blue, Meghan E Beddow, Mariam Savabi, Vivek R Katukuri, Ellen L Mozurkewich, Conrad R Chao
OBJECTIVE: The Royal College of Obstetricians and Gynaecologists (RCOG) defines fetal growth restriction as ultrasound-estimated fetal weight less than the 10th percentile or abdominal circumference less than the 10th percentile; the American College of Obstetricians and Gynecologists (ACOG) defines fetal growth restriction as estimated fetal weight less than the 10th percentile alone. We compared each method's ability to predict small for gestational age (SGA) at birth. METHODS: For this retrospective study of diagnostic accuracy, we reviewed deliveries at the University of New Mexico Hospital from January 1, 2013, to March 31, 2017...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29626979/placental-exosomes-profile-in-maternal-and-fetal-circulation-in-intrauterine-growth-restriction-liquid-biopsies-to-monitoring-fetal-growth
#17
Jezid Miranda, Cristina Paules, Soumyalekshmi Nair, Andrew Lai, Carlos Palma, Katherin Scholz-Romero, Gregory E Rice, Eduard Gratacos, Fatima Crispi, Carlos Salomon
INTRODUCTION: Placenta-derived exosomes may represent an additional pathway by which the placenta communicates with the maternal system to induce maternal vascular adaptations to pregnancy and it may be affected during Fetal growth restriction (FGR). The objective of this study was to quantify the concentration of total and placenta-derived exosomes in maternal and fetal circulation in small fetuses classified as FGR or small for gestational age (SGA). METHODS: Prospective cohort study in singleton term gestations including 10 normally grown fetuses and 20 small fetuses, sub-classified into SGA and FGR accordingly to birth weight (BW) percentile and fetoplacental Doppler...
April 2018: Placenta
https://www.readbyqxmd.com/read/29626501/birth-weight-predicts-aging-trajectory-a-hypothesis
#18
REVIEW
Alexander M Vaiserman
Increasing evidence suggests that risk for age-related disease and longevity can be programmed early in life. In human populations, convincing evidence has been accumulated indicating that intrauterine growth restriction (IUGR) resulting in low birth weight (<2.5 kg) followed by postnatal catch-up growth is associated with various aspects of metabolic syndrome, type 2 diabetes and cardiovascular disease in adulthood. Fetal macrosomia (birth weight >4.5 kg), by contrast, is associated with high risk of non-diabetic obesity and cancers in later life...
April 4, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29626273/hyperelastic-mechanical-properties-of-ex-vivo-normal-and-intrauterine-growth-restricted-placenta
#19
Shier Nee Saw, Jess Yi Ru Low, May Han Huang Ong, Yu Wei Poh, Citra Nurfarah Zaini Mattar, Arijit Biswas, Choon Hwai Yap
Intrauterine Growth Restriction (IUGR) is a serious and prevalent pregnancy complication that is due to placental insufficiency and IUGR babies suffer significantly higher risks of mortality and morbidity. Current detection rate for IUGR is generally poor and thus an alternative diagnostic tool is needed to improve the IUGR detection. Elastography, a non-invasive method that measures the tissue stiffness, has been proposed as one such technique. However, to date, we have limited information on the mechanical properties of IUGR placenta...
April 6, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29620597/early-serum-gut-hormone-concentrations-associated-with-time-to-full-enteral-feedings-in-preterm-infants
#20
Kristen H Shanahan, Xinting Yu, Laura G Miller, Steven D Freedman, Camilia R Martin
OBJECTIVES: The primary objective of this study was to evaluate early postnatal serum gut hormone concentrations in preterm infants as predictors of time to full enteral feedings. The secondary objective was to identify infant characteristics and nutritional factors that modulate serum gut hormone concentrations and time to full enteral feedings. METHODS: Sixty-four preterm infants less than 30 weeks of gestation were included in this retrospective cohort study...
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
keyword
keyword
8494
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"