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Goiter in children

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https://www.readbyqxmd.com/read/28387647/management-of-childhood-thyroid-nodules-surgical-and-endocrinological-experience-in-more-than-one-hundred-cases
#1
Emre Divarcı, Ülgen Celtik, Zafer Dökümcü, Orkan Ergün, Geylani Özok, Samim Özen, Damla Gökşen Şimşek, Şükran Darcan, Nazan Çetingül, Aylin Oral, Yeşim Ertan, Bengü Demirağ, Ahmet Çelik
OBJECTIVE: The management of childhood thyroid nodules is still a big challenge for clinicians. In this study, we aimed to present our surgical and endocrinological experience in more than one hundred cases as a large experience in children. METHODS: Retrospective analysis of patients admitted with a thyroid nodule between 2006-2014 was performed. Detailed ultrasonography and fine needle aspiration biopsy(FNAB) were the corner stones of the diagnostic approach. RESULTS: One hundred-three children(72F,31M) with a mean age of 13...
April 7, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28381452/management-of-endocrine-disease-arguments-for-the-prolonged-use-of-antithyroid-drugs-in-children-with-graves-disease
#2
Juliane Leger, Jean-Claude Carel
Graves' disease is an autoimmune disorder. It is the major cause of hyperthyroidism but is rare in children. Patients are initially managed with antithyroid drugs (ATD), in the form of methimazole/carbimazole. A major disadvantage of ATD treatment is the high risk of relapse, exceeding 70% of children treated for a duration of two years, and the potential major side effects of the drug reported in exceptional cases. The major advantage of ATD treatment is that normal homeostasis of the hypothalamus-pituitary thyroid axis may be restored, with periods of drug treatment followed by freedom from medical intervention achieved in about 40 to 50% of cases after prolonged ATD treatment for several years in recent studies...
April 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28348999/goiter-prevalence-in-school-going-children-a-cross-sectional-study-in-two-border-districts-of-sub-himalayan-jammu-and-kashmir
#3
Rajiv Kumar Gupta, Bhavna Langer, Sunil Kumar Raina, Rashmi Kumari, Reyaz Jan, Renu Rani
INTRODUCTION: Iodine deficiency disorder remains one of the major public health problems, despite it being easily preventable. Initially thought as the disorder of Himalayan goiter belt, the disorder has been found to have a pan-India presence. The study was planned with the aim to assess the prevalence of goiter among 6-12 years school-going children and to identify levels of iodine in salt consumed at the household level in the study area. MATERIALS AND METHODS: The study was conducted among 3955 school-going (2162 children from Rajouri and 1793 children from Poonch) children age 6-12 years in Rajouri and Poonch districts of Jammu Province...
October 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28331628/association-of-iodized-salt-with-goiter-prevalence-in-chinese-populations-a-continuity-analysis-over-time
#4
Zhen Liang, Chen Xu, Yong-Jun Luo
BACKGROUND: Iodine deficiency disorders (IDD) refer to diseases that are caused by insufficient iodine intake, and the best strategy to prevent IDD is the addition of iodine to dietary salt. Because iodine deficiency is a common cause of goiter, the prevalence as effectively controlled after the implementation of universal salt iodization (USI) in China. However, there is substantial controversy as to whether the incidence of thyroid disorders is related to iodized salt intake. Therefore, we aimed to clarify whether the risk of goiter can be promoted by USI...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28328929/urinary-iodine-concentration-uic-could-be-a-promising-biomarker-for-predicting-goiter-among-school-age-children-a-systematic-review-and-meta-analysis
#5
Linlin Xiu, Gansheng Zhong, Xueman Ma
OBJECTIVES: To evaluate whether urinary iodine concentration (UIC) can predict goiter among school-age children, and to assess the association between UIC and goiter prevalence. METHODS: We searched the MEDLINE, EMBASE, Cochrane Library (Cochrane Database of Systematic Reviews), Web of Science, CNKI, VIP, and Wan Fang databases for relevant reports in both English and Chinese up to August 25, 2016. The mean differences (MD) and 95% confidence intervals (CI) were calculated for the UIC and goiter prevalence assessments...
2017: PloS One
https://www.readbyqxmd.com/read/28294052/iodine-deficiency-and-iodine-prophylaxis-in-pregnancy
#6
Małgorzata Trofimiuk-Müdlner, Alicja Hubalewska-Dydejczyk
BACKGROUND: Physiological changes in pregnancy result in increased iodine demand, which may not be met in areas of mild-to-moderate iodine deficiency or borderline sufficiency. As a pregnant woman is the only source of thyroid hormones for her child during early gestation, iodine deficiency-induced hypothyroxinemia may have deleterious effects on fetal development. OBJECTIVE: To present the current approach to iodine deficiency and its prophylaxis during pregnancy...
March 9, 2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28292346/surveys-in-areas-of-high-risk-of-iodine-deficiency-and-iodine-excess-in-china-2012-2014-current-status-and-examination-of-the-relationship-between-urinary-iodine-concentration-and-goiter-prevalence-in-children-aged-8-10-years
#7
Fang Yao, Jia Yan Zhang, Xiang Xiao, Ying Dong
OBJECTIVE: We aimed to evaluate goiter prevalence and iodine nutritional status in areas with high levels of water iodine; to monitor the prevalence of iodine deficiency disorders (IDD) in areas at high risk of IDD; and to compare the prevalence of goiter and urine iodine (UI) concentrations between children living in the two areas. METHODS: Based on surveillance from 2012-2014, we analyzed the concentration of UI and prevalence of goiter in 8-10-year-old children from 12 high-risk IDD provinces, and from 8 provinces and municipalities with excessive water iodine...
February 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28273705/-genetic-analysis-of-tpo-duox2-and-duoxa2-genes-in-children-with-permanent-congenital-hypothyroidism-suspected-dyshormonogenesis
#8
Y L Huang, M Y Tan, X Jiang, B Li, Q Y Chen, X F Jia, C F Tang, J L Liu, L Liu
Objective: To explore the TPO, DUOX2 and DUOXA2 genotypes and phenotypes of children with permanent congenital hypothyroidism(PCH) suspected dyshormonogenesis in Guangzhou, identified and treated at Guangzhou Newborn Screening Center. Six of them were born between 2011 and 2012. Method: Retrospectively analyzed the clinical data of 9 children with PCH suspected dyshormonogenesis. Genetic analysis of TPO, DUOX2 and DUOXA2 genes were performed with Sanger sequencing. Result: Of the 9 patients, four were identified variants in TPO gene including three cases with biallelic variants and one case with monoallelic variant...
March 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28222777/identification-of-somatic-and-germ-line-dicer1-mutations-in-pleuropulmonary-blastoma-cystic-nephroma-and-rhabdomyosarcoma-tumors-within-a-dicer1-syndrome-pedigree
#9
Lorena Fernández-Martínez, José Antonio Villegas, Íñigo Santamaría, Ana S Pitiot, Marta G Alvarado, Soledad Fernández, Héctor Torres, Ángeles Paredes, Pilar Blay, Milagros Balbín
BACKGROUND: DICER1 syndrome is a pediatric cancer predisposition condition causing a variety of tumor types in children and young adults. In this report we studied a family with two relatives presenting a variety of neoplastic conditions at childhood. METHODS: Germ-line mutation screening of the complete coding region of the DICER1 gene in genomic DNA from the proband was performed. The presence of somatic DICER1 mutation and further alterations in driver genes was investigated in genomic DNA obtained from available tumor samples...
February 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28217504/improving-iodine-nutritional-status-and-increasing-prevalence-of-autoimmune-thyroiditis-in-children
#10
Srinivasan Palaniappan, Lakshmi Shanmughavelu, Hemchand K Prasad, Sundari Subramaniam, Nedunchezian Krishnamoorthy, Lakshmi Lakkappa
OBJECTIVE: The objective of this study is to evaluate the link between excess iodine intake as evidenced by increased urinary iodine excretion (UIE) and autoimmune thyroiditis in children and to assess the correlation between UIE and thyroid microsomal antibody (thyroid peroxidase [TPO]) titers in children. MATERIALS AND METHODS: All children with goiter between age group 6 and 12 years, were subjected to blood tests for free thyroxine, thyroid stimulating hormone, and TPO antibody, fine needle aspiration was advised for all children with goiter...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28061776/poor-dietary-diversity-wealth-status-and-use-of-un-iodized-salt-are-associated-with-goiter-among-school-children-a-cross-sectional-study-in-ethiopia
#11
Zegeye Abebe, Ejigu Gebeye, Amare Tariku
BACKGROUND: Globally, more than two billion people are at risk of iodine deficiency disorders, 32% of which are school children. Iodine deficiency has been recognized as a severe public health concern in Ethiopia, however little is known about the problem. Therefore, this study aimed to assess the prevalence of goiter and associated factors among school children (6 to 12 years) in Dabat District, northwest Ethiopia. METHODS: A school-based cross-sectional study was conducted from February 21 to March 31, 2016...
January 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28003823/larger-thyroid-volume-and-adequate-iodine-nutrition-in-chinese-schoolchildren-local-normative-reference-values-compared-with-who-ign
#12
Zhe Mo, Xiaoming Lou, Guangming Mao, Zhifang Wang, Wenming Zhu, Zhijian Chen, Xiaofeng Wang
Objective. Thyroid volume measured by ultrasound to define goiter needs reliable local thyroid volume reference from iodine-sufficient populations. The aim of this study is to explore the reference interval for normal thyroid volume in schoolchildren aged 8-10 years from Zhejiang Province, China. Methods. A probability-proportionate-to-size sampling method was applied to select a representative sample of 1213 children aged 8-10 years in Zhejiang Province to detect the thyroid volume, salt iodine, and urine iodine...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28001012/iodine-deficiency-and-nutrition-in-scandinavia
#13
REVIEW
Sofia Manousou, Lisbeth Dahl, Betina Heinsbaek Thuesen, Lena Hulthén, Helena Nyström Filipsson
Iodine nutrition is a result of geological conditions, iodine fortification and monitoring strategies within a country together with the dietary habits of the population. This review summarizes the basis for the current iodine situation in the Scandinavian countries in order to identify gaps in knowledge, determine necessary future steps, highlight landmarks in Scandinavian iodine research and consider ongoing studies in Scandinavian countries with high international impact. Historically, iodine deficiency disorders such as goiter were common in Norway and Sweden, but not in Denmark...
April 2017: Minerva Medica
https://www.readbyqxmd.com/read/27942480/diagnostic-imaging-of-benign-and-malignant-neck-masses-in-children-a-pictorial-review
#14
REVIEW
Ruth Elizabeth Brown, Srikrishna Harave
Neck masses are frequently encountered in pediatric medicine, and can present a diagnostic dilemma for the clinicians involved. There are several means by which neck masses in children can be subdivided, for example by age at presentation, anatomical location including compartments and fascia of the neck, their classical appearance when imaged, or by etiology. When imaging children the clinicians must be mindful of radiation exposure and as such ultrasound (US) is often attempted first. Cross sectional imaging can be helpful for problem solving with CT being particularly useful for assessing the patient in more acute scenarios, for example when there is airway compromise...
October 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27927635/associations-between-iodine-intake-thyroid-volume-and-goiter-rate-in-school-aged-chinese-children-from-areas-with-high-iodine-drinking-water-concentrations
#15
Wen Chen, Xiang Li, Yalan Wu, Jianchao Bian, Jun Shen, Wen Jiang, Long Tan, Xiaoming Wang, Wei Wang, Elizabeth N Pearce, Michael B Zimmermann, Alicia L Carriquiry, Wanqi Zhang
BACKGROUND: Excessive iodine intake may have adverse effects on the thyroid, particularly in children, but the safe upper iodine intake concentration in children is unclear. OBJECTIVE: We assessed the adverse effects of high iodine intake from iodine-rich drinking water on thyroid size in children by examining associations between thyroid volume (Tvol), total goiter rate (TGR), and iodine intake. DESIGN: In a multistage cross-sectional survey, we collected two 24-h urine samples on 2 nonconsecutive days and determined 24-h urinary iodine excretion, then calculated habitual daily iodine intake...
January 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27867886/genotype-phenotype-correlations-of-dyshormonogenetic-goiter-in-children-and-adolescents-from-south-india
#16
Bangaraiah Gari Ramesh, Panchangam Ramakanth Bhargav, Bangaraiah Gari Rajesh, Nangedda Vimala Devi, Rajagopalan Vijayaraghavan, Bhongir Aparna Varma
BACKGROUND: Dyshormonogenetic goiter is one of the most common causes of hypothyroidism in children and adolescents in iodine nonendemic areas. The exact genotype-phenotypic correlations (GPCs) and risk categorization of hypothyroid phenotypes of dyshormonogenetic mutations are largely speculative. The genetic studies in pediatric dyshormonogenesis are very sparse from Indian sub-continent. In this context, we analyzed the implications of TPO, NIS, and DUOX2 gene mutations in hypothyroid children with dyshormonogenetic hypothyroidism (DH) from South India...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27807474/iodine-deficiency-and-associated-factors-among-school-children-a-cross-sectional-study-in-ethiopia
#17
Sintayehu Hailu, Mamo Wubshet, Haile Woldie, Amare Tariku
BACKGROUND: Iodine deficiency remains a public health problem in the world. It is the leading cause of preventable mental retardation and brain damage worldwide. Though 12 million school age children are at risk of developing iodine deficiency, there is a scarcity of literature showing the magnitude of iodine deficiency in Ethiopia. Therefore, this study aimed to determine the prevalence and associated factors of iodine deficiency among school children in Robe District, southeast Ethiopia...
2016: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/27567653/iodine-deficiency-in-school-children-in-aligarh-district-india
#18
Ahmad Nadeem Aslami, Mohammed A Ansari, N Khalique, Umesh Kapil
We carried out this study to assess iodine deficiency disorders among school children of 6-12 years age group in Aligarh district of India. The prevalence of goiter was 5.2%. Median Urinary Iodine Excretion level was 150 ug/L; 22.5% of students had biochemical iodine deficiency. 50.4% households were consuming adequately iodized salt.
August 8, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27560630/current-status-of-iodine-deficiency-related-disorders-prophylaxis-in-slovakia-the-life-s-work-of-julian-podoba-remained-unfinished
#19
J Podoba, K Racova, H Urbankova, M Srbecky
OBJECTIVE: Prophylaxis of iodine deficiency-related disorders with iodized salt in Slovakia was introduced in 1951. This prophylactic measure yielded remarkably good results. Endemic goiter and endemic cretinism disappeared. Sufficient iodine intake, mainly in children and adolescents, was confirmed in several local and international studies carried out in the period 1991-95. Unfortunately, since seventies, there has been no institution which would have dealt with iodine prophylaxis in such an extent as this important measure of Slovak preventive medicine would require...
January 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27541030/ethical-and-surgical-dilemmas-in-patients-with-neglected-surgical-diseases-visiting-a-field-hospital-in-a-zone-of-recent-disaster
#20
Guy Lin, Tal Marom, David Dagan, Ofer Merin
OBJECT: The massive typhoon Haiyan (Yolanda) ripped across the central Philippines on November 8, 2013, and damaged infrastructure including hospitals. The Israeli Defense Forces field hospital was directed by the Philippine authorities to Bogo City in the northern part of the island of Cebu, to assist the damaged local hospital. Hundreds of patients with neglected diseases sought for medical treatment which was merely out of reach for them. Our ethical dilemmas were whether to intervene, when the treatment we could offer was not the best possible...
August 19, 2016: World Journal of Surgery
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