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https://www.readbyqxmd.com/read/28816645/a-systems-model-of-parkinson-s-disease-using-biochemical-systems-theory
#1
Hemalatha Sasidharakurup, Nidheesh Melethadathil, Bipin Nair, Shyam Diwakar
Parkinson's disease (PD), a neurodegenerative disorder, affects millions of people and has gained attention because of its clinical roles affecting behaviors related to motor and nonmotor symptoms. Although studies on PD from various aspects are becoming popular, few rely on predictive systems modeling approaches. Using Biochemical Systems Theory (BST), this article attempts to model and characterize dopaminergic cell death and understand pathophysiology of progression of PD. PD pathways were modeled using stochastic differential equations incorporating law of mass action, and initial concentrations for the modeled proteins were obtained from literature...
August 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28810928/gait-characteristics-and-their-discriminative-power-in-geriatric-patients-with-and-without-cognitive-impairment
#2
Lisette H J C Kikkert, Nicolas Vuillerme, Jos P van Campen, Bregje A Appels, Tibor Hortobágyi, Claudine J Lamoth
BACKGROUND: A detailed gait analysis (e.g., measures related to speed, self-affinity, stability, and variability) can help to unravel the underlying causes of gait dysfunction, and identify cognitive impairment. However, because geriatric patients present with multiple conditions that also affect gait, results from healthy old adults cannot easily be extrapolated to geriatric patients. Hence, we (1) quantified gait outcomes based on dynamical systems theory, and (2) determined their discriminative power in three groups: healthy old adults, geriatric patients with- and geriatric patients without cognitive impairment...
August 15, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28795937/creating-a-social-media-assessment-tool-for-family-nursing
#3
Tracie Risling, Derek Risling, Lorraine Holtslander
The use of social media (SM) is contributing to an unprecedented state of global connectivity and occupying an increasingly prominent position in the lives of individuals and families. The more integrated these media become into society the more likely they are to play a role in overall health and family functioning, be it positively or negatively. Family systems theory provides an ideal lens through which to examine the effects of SM in today's family life. This article introduces a new SM assessment tool aligned with the principles of this foundational theory...
February 2017: Journal of Family Nursing
https://www.readbyqxmd.com/read/28793759/statistical-teleodynamics-toward-a-theory-of-emergence
#4
Venkat Venkatasubramanian
The central scientific challenge of the 21st century is developing a mathematical theory of emergence that can explain and predict phenomena such as consciousness and self-awareness. The most successful research program of the 20th century, reductionism, which goes from whole to parts, seems unable to address this challenge. This is because addressing this challenge inherently requires an opposite approach, going from parts to whole. In addition, reductionism, by the very nature of its enquiry, typically doesn't concern itself with teleology or purposeful behavior...
August 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28773073/studies-on-mathematical-models-of-wet-adhesion-and-lifetime-prediction-of-organic-coating-steel-by-grey-system-theory
#5
Fandi Meng, Ying Liu, Li Liu, Ying Li, Fuhui Wang
A rapid degradation of wet adhesion is the key factor controlling coating lifetime, for the organic coatings under marine hydrostatic pressure. The mathematical models of wet adhesion have been studied by Grey System Theory (GST). Grey models (GM) (1, 1) of epoxy varnish (EV) coating/steel and epoxy glass flake (EGF) coating/steel have been established, and a lifetime prediction formula has been proposed on the basis of these models. The precision assessments indicate that the established models are accurate, and the prediction formula is capable of making precise lifetime forecasting of the coatings...
June 28, 2017: Materials
https://www.readbyqxmd.com/read/28744316/the-antidepressant-and-cognitive-improvement-activities-of-the-traditional-chinese-herb-cistanche
#6
Dongfang Wang, Haizhen Wang, Li Gu
More than ten percent of people suffer from at least one episode of depression and related mental disorders in a lifetime, and depression and related mental disorders are one of the world's greatest public health problems. A multiple system theory holds that dysregulation of the multiple systems underlies the pathogenesis of depression and related mental disorders, and new therapies based on the multiple system dysregulation theory are urgently needed. In this study, the antidepressant effect of decoction from herb Cistanche deserticola Y...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28734094/moving-alcohol-prevention-research-forward-part-i-introducing-a-complex-systems-paradigm
#7
Yorghos Apostolopoulos, Michael K Lemke, Adam E Barry, Kristen Hassmiller Lich
BACKGROUND AND AIMS: The drinking environment is a complex system consisting of a number of heterogeneous, evolving, and interacting components, which exhibit circular causality and emergent properties. These characteristics reduce the efficacy of commonly used research approaches, which typically do not account for the underlying dynamic complexity of alcohol consumption and the interdependent nature of diverse factors influencing misuse over time. We use alcohol misuse among college students in the United States as an example for framing our argument for a complex systems paradigm...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28726443/contextualizing-risk-and-protection-perceptions-of-bedouin-mothers-from-unrecognized-villages-in-the-naqab
#8
Ibtisam Marey-Sarwan, Dorit Roer-Strier, Hiltrud Otto
This qualitative study utilizes ecological theory, a context-informed perspective, and an interactive model to study minority children, while considering structural factors, oppression, segregation, power dynamics, and awareness of the political context. It examines perceptions of risk and protection using "snowball" sampling of 33 Bedouin mothers, citizens of Israel, from the unrecognized villages (UVs) in the Naqab in Southern Israel. Data were collected via in-depth, semistructured interviews during 2011 to 2013...
July 20, 2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28724155/a-family-systems-curriculum-back-to-the-future
#9
Rebekah Schiefer, Alexandra Verdieck Devlaeminck, Holly Hofkamp, Sheldon Levy, Demetrio Sanchez, John Muench
BACKGROUND AND OBJECTIVES: Although both residents and teaching faculty endorse its value, a recent review of family medicine residency programs confirms minimal formal family systems theory training. We consider the historical context of family systems training in family medicine and other competing priorities in practice and residency curricula. METHODS: We developed a longitudinal family systems curriculum, delivered in the third year of a 4-year residency program, and evaluated 2 years of the program using scales to assess self-reported confidence, knowledge and skills...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28713872/systems-medicine-complexity-within-simplicity-without
#10
EDITORIAL
Richard Berlin, Russell Gruen, James Best
This paper presents a brief history of Systems Theory, progresses to Systems Biology, and its relation to the more traditional investigative method of reductionism. The emergence of Systems Medicine represents the application of Systems Biology to disease and clinical issues. The challenges faced by this transition from Systems Biology to Systems Medicine are explained; the requirements of physicians at the bedside, caring for patients, as well as the place of human-human interaction and the needs of the patients are addressed...
2017: J Healthc Inform Res
https://www.readbyqxmd.com/read/28712371/visual-systemizing-preference-in-children-with-autism-a-randomized-controlled-trial-of-intranasal-oxytocin
#11
Lane Strathearn, Sohye Kim, D Anthony Bastian, Jennifer Jung, Udita Iyengar, Sheila Martinez, Robin P Goin-Kochel, Peter Fonagy
Several studies have suggested that the neuropeptide oxytocin may enhance aspects of social communication in autism. Little is known, however, about its effects on nonsocial manifestations, such as restricted interests and repetitive behaviors. In the empathizing-systemizing theory of autism, social deficits are described along the continuum of empathizing ability, whereas nonsocial aspects are characterized in terms of an increased preference for patterned or rule-based systems, called systemizing. We therefore developed an automated eye-tracking task to test whether children and adolescents with autism spectrum disorder (ASD) compared to matched controls display a visual preference for more highly organized and structured (systemized) real-life images...
July 17, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28708004/psychological-trait-resilience-within-ecological-systems-theory-the-resilient-systems-scales
#12
John Maltby, Liz Day, Heather D Flowe, Panos Vostanis, Sally Chivers
This project describes the development of the Resilient Systems Scales, created to address conceptual and methodological ambiguities in assessing the ecological systems model of resilience. Across a number of samples (total N = 986), our findings suggest that the Resilient Systems Scales show equivalence to a previously reported assessment (Maltby, Day, & Hall, 2015 ) in demonstrating the same factor structure, adequate intercorrelation between the 2 measures of resilience, and equivalent associations with personality and well-being...
July 14, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28706465/disability-and-the-family-in-south-wales-coalfield-society-c-1920-1939
#13
Ben Curtis, Steven Thompson
This article utilises the south Wales coalfield in the interwar period as a case study to illustrate the applicability of two sociological theories - family systems theory and the social ecology of the family - to impairment in the past. It demonstrates that a theoretically-informed approach can help to situate impairment in its particular contexts, most especially the family and the community, and give a better sense of the lived experience of disability. It also demonstrates the complexity of the experience of disability as the family and economic circumstances of each impaired individual varied and led to different forms of care-giving or the utilisation of different sources of support...
January 2, 2017: Family & Community History: Journal of the Family and Community Historical Research Society
https://www.readbyqxmd.com/read/28687051/from-experiments-to-ecosystems-reviewing-public-participation-scientific-governance-and-the-systemic-turn
#14
Kathrin Braun, Sabine Könninger
The article discusses a recent systemic turn in public participation in science studies. It reviews the main lines of criticism brought forward in science, technology and society towards public participation in science discourse and argues that much of it refers to the field's preoccupation with isolated, stage-managed minipublics. It then discusses a series of efforts in science, technology and society, and other fields to study public participation in a more systemic or holistic perspective. The article advances the argument that there are different ways of conceptualizing such a perspective, not all of which are well equipped to account for contestation, conflict and power...
July 1, 2017: Public Understanding of Science
https://www.readbyqxmd.com/read/28681444/a-call-to-incorporate-systems-theory-and-human-factors-into-the-existing-investigation-of-harm-in-clinical-research-involving-healthcare-products
#15
Bernard Bégaud, Esther Daemen, Ioannis Dokas, Brian Edwards, Jonathan M Fishbein, Howard E Greenberg, Alan Hochberg, Hervé Le Louet, Jytte Lyngvig, Nataliya Mogles, Kathryn Owen, Christine Prendergast, Martin Rejzek, Sofia Trantza, David Webb, Matthew Whalen, Simon Whiteley
This is a joint statement from individual pharmacology and pharmaceutical professionals acting in their own capacity including members of the Alliance for Clinical Research Excellence and Safety (ACRES) and the International Society of Pharmacovigilance (ISoP). By building on the extensive pharmacological and regulatory investigations that already take place, we are calling for a fuller and more robust systems-based approach to the independent investigation of clinical research when serious incidents of harm occur, starting with first-in-human clinical trials...
July 6, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28680696/in-hospital-experiences-of-families-of-potential-organ-donors-a-systematic-review-and-qualitative-synthesis
#16
REVIEW
Sean Glenton Dicks, Kristen Ranse, Frank Mp van Haren, Douglas P Boer
Information and compassion assist families of potential organ donors to make informed decisions. However, psychological implications of the in-hospital process are not well described with past research focusing on decision-making. To enhance understanding and improve service delivery, a systematic review was conducted. Inductive analysis and synthesis utilised Grounded Theory Methodology within a systems theory framework and contributed to a model proposing that family and staff form a System of Systems with shared responsibility for process outcomes...
April 2017: Health Psychology Open
https://www.readbyqxmd.com/read/28679221/revival-of-oscillations-from-deaths-in-diffusively-coupled-nonlinear-systems-theory-and-experiment
#17
Wei Zou, Michael Sebek, István Z Kiss, Jürgen Kurths
Amplitude death (AD) and oscillation death (OD) are two structurally different oscillation quenching phenomena in coupled nonlinear systems. As a reverse issue of AD and OD, revival of oscillations from deaths attracts an increasing attention recently. In this paper, we clearly disclose that a time delay in the self-feedback component of the coupling destabilizes not only AD but also OD, and even the AD to OD transition in paradigmatic models of coupled Stuart-Landau oscillators under diverse death configurations...
June 2017: Chaos
https://www.readbyqxmd.com/read/28654644/net-profit-flow-per-country-from-1980-to-2009-the-long-term-effects-of-foreign-direct-investment
#18
Dirk H M Akkermans
AIM OF THE PAPER: The paper aims at describing and explaining net profit flows per country for the period 1980-2009. Net profit flows result from Foreign Direct Investment (FDI) stock and profit repatriation: inward stock creating a profit outflow and outward FDI stock a profit inflow. Profit flows, especially 'normal' ones are not commonly researched. THEORETICAL BACKGROUND: According to world-system theory, countries are part of a system characterised by a core, semi-periphery and periphery, as shown by network analyses of trade relations...
2017: PloS One
https://www.readbyqxmd.com/read/28649968/real-time-polymer-nanocomposites-based-physical-nanosensors-theory-and-modeling
#19
Stefano Bellucci, Yuri Shunin, Victor Gopeyenko, Tamara Lobanova-Shunina, Nataly Burlutskaya, Yuri Zhukovskii
Functionalized carbon nanotubes and graphene nanoribbons nanostructures, serving as the basis for the creation of physical pressure and temperature nanosensors, are considered as tools for ecological monitoring and medical applications. Fragments of nanocarbon inclusions with different morphologies, presenting a disordered system, are regarded as models for nanocomposite materials based on carbon nanoсluster suspension in dielectric polymer environments (e.g., epoxy resins). We have formulated the approach of conductivity calculations for carbon-based polymer nanocomposites using the effective media cluster approach, disordered systems theory and conductivity mechanisms analysis, and obtained the calibration dependences...
June 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28649120/must-we-embody-context
#20
Barbara Hahn
The essays in this forum brace this meditation on the historiography of technology. Understanding devices incorporates the context of any particular hardware, as John Staudenmaier showed by quantifying the contents of the first decades of Technology and Culture. As contextualist approaches have widened from systems theory through social construction and into the assemblages of actor-network theory, the discipline has kept artifacts at the analytical center: it is the history of technology that scholars seek to understand...
2017: Technology and Culture
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