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https://www.readbyqxmd.com/read/28640191/phenotypic-plasticity-and-cell-fate-decisions-in-cancer-insights-from-dynamical-systems-theory
#1
REVIEW
Dongya Jia, Mohit Kumar Jolly, Prakash Kulkarni, Herbert Levine
Waddington's epigenetic landscape, a famous metaphor in developmental biology, depicts how a stem cell progresses from an undifferentiated phenotype to a differentiated one. The concept of "landscape" in the context of dynamical systems theory represents a high-dimensional space, in which each cell phenotype is considered as an "attractor" that is determined by interactions between multiple molecular players, and is buffered against environmental fluctuations. In addition, biological noise is thought to play an important role during these cell-fate decisions and in fact controls transitions between different phenotypes...
June 22, 2017: Cancers
https://www.readbyqxmd.com/read/28623778/are-there-signature-limits-in-early-theory-of-mind
#2
Ella Fizke, Stephen Butterfill, Lea van de Loo, Eva Reindl, Hannes Rakoczy
Current theory-of-mind research faces the challenge of reconciling two sets of seemingly incompatible findings: Whereas children come to solve explicit verbal false belief (FB) tasks from around 4years of age, recent studies with various less explicit measures such as looking time, anticipatory looking, and spontaneous behavior suggest that even infants can succeed on some FB tasks. In response to this tension, two-systems theories propose to distinguish between an early-developing system, tracking simple forms of mental states, and a later-developing system, based on fully developed concepts of belief and other propositional attitudes...
June 14, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28623593/boolean-dynamic-modeling-approaches-to-study-plant-gene-regulatory-networks-integration-validation-and-prediction
#3
José Dávila Velderraín, Juan Carlos Martínez-García, Elena R Álvarez-Buylla
Mathematical models based on dynamical systems theory are well-suited tools for the integration of available molecular experimental data into coherent frameworks in order to propose hypotheses about the cooperative regulatory mechanisms driving developmental processes. Computational analysis of the proposed models using well-established methods enables testing the hypotheses by contrasting predictions with observations. Within such framework, Boolean gene regulatory network dynamical models have been extensively used in modeling plant development...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28618079/protected-areas-as-social-ecological-systems-perspectives-from-resilience-and-social-ecological-systems-theory
#4
Graeme S Cumming, Craig R Allen
Conservation biology and applied ecology increasingly recognise that natural resource management is both an outcome and a driver of social, economic, and ecological dynamics. Protected areas offer a fundamental approach to conserving ecosystems, but they are also social-ecological systems whose ecological management and sustainability are heavily influenced by people. This editorial, and the papers in the invited feature that it introduces, discuss three emerging themes in social-ecological systems approaches to understanding protected areas: (1) the resilience and sustainability of protected areas, including analyses of their internal dynamics, their effectiveness, and the resilience of the landscapes within which they occur; (2) the relevance of spatial context and scale for protected areas, including such factors as geographic connectivity, context, exchanges between protected areas and their surrounding landscapes, and scale dependency in the provision of ecosystem services; and (3) efforts to re-frame what protected areas are and how they both define and are defined by the relationships of people and nature...
June 15, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28600136/an-all-encompassing-global-convergence-result-for-processive-multisite-phosphorylation-systems
#5
Mitchell Eithun, Anne Shiu
Phosphorylation, the enzyme-mediated addition of a phosphate group to a molecule, is a ubiquitous chemical mechanism in biology. Multisite phosphorylation, the addition of phosphate groups to multiple sites of a single molecule, may be distributive or processive. Distributive systems, which require an enzyme and substrate to bind several times in order to add multiple phosphate groups, can be bistable. Processive systems, in contrast, require only one binding to add all phosphate groups, and were recently shown to be globally stable...
June 6, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28594600/psychosocial-and-environmental-factors-in-the-prognosis-of-individuals-with-chronic-pain-and-comorbid-mental-health
#6
Valerie Hruschak, Gerald Cochran
Chronic pain has considerable medical, social, and economic implications as its high prevalence rate and negative societal burden provides justification that it is a major health issue. The value of understanding psychological, social, and environmental factors in chronic pain has become widely recognized and accepted as a biopsychosocial phenomenon in which the social work perspective offers a valuable lens. Through the critical application of systems theory and ecological perspective, accompanied with the diathesis stress model, this article examines psychosocial and environmental influences as being contributory factors in the prognosis of individuals with chronic pain and comorbid mental health disorders...
June 8, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28589465/timescales-and-mechanisms-of-sigh-like-bursting-and-spiking-in-models-of-rhythmic-respiratory-neurons
#7
Yangyang Wang, Jonathan E Rubin
Neural networks generate a variety of rhythmic activity patterns, often involving different timescales. One example arises in the respiratory network in the pre-Bötzinger complex of the mammalian brainstem, which can generate the eupneic rhythm associated with normal respiration as well as recurrent low-frequency, large-amplitude bursts associated with sighing. Two competing hypotheses have been proposed to explain sigh generation: the recruitment of a neuronal population distinct from the eupneic rhythm-generating subpopulation or the reconfiguration of activity within a single population...
December 2017: Journal of Mathematical Neuroscience
https://www.readbyqxmd.com/read/28579076/resilience-in-young-children-involved-with-child-protective-services
#8
Kierra M P Sattler, Sarah A Font
Child maltreatment increases the risk of poor developmental outcomes. However, some children display resilience, meaning they are high-functioning despite their adverse experiences. To date, few research studies have examined protective factors among very young maltreated children. Yet, levels of resilience, and the protective factors that promote resilience among maltreated children, are likely to differ by developmental stage. Drawing on ecological systems theory and life course theory, we examined how protective factors at multiple ecological levels across early childhood were related to social and cognitive resilience among very young children involved with child protective services...
June 1, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28578997/-the-human-use-of-human-beings-interdisciplinarity-transdisciplinarity-and-all-that-in-biophysics-and-beyond
#9
Marco Elio Tabacchi, Settimo Termini
Biophysics, just by looking at its name, indicates an interdisciplinary scientific activity, although the notion of interdisciplinarity, as such, seems to be not widely or specifically discussed by biophysicists. The same seems to have happened as well in the early stages of the development of cybernetics, notably in Norbert Wiener's writings. This situation seems to contrast with what has happened in subsequent developments of cybernetics ideas, notably in general system theory and cognitive sciences. After a few general reflections on the notion of interdisciplinarity, its sophisticated variants and the path leading to the birth of cognitive science, we shall refer to Wiener's thought to extracts aspects and indications that could be useful today, also for what concerns the social responsibility of scientists, which could be seen as stemming from a very general form of interdisciplinarity...
May 19, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28562503/rebooting-kirkpatrick-integrating-information-system-theory-into-the-evaluation-of-web-based-continuing-professional-development-interventions-for-interprofessional-education
#10
Nelson Shen, Shira Yufe, Omid Saadatfard, Sanjeev Sockalingam, David Wiljer
INTRODUCTION: Information system research has stressed the importance of theory in understanding how user perceptions can motivate the use and adoption of technology such as web-based continuing professional development programs for interprofessional education (WCPD-IPE). A systematic review was conducted to provide an information system perspective on the current state of WCPD-IPE program evaluation and how current evaluations capture essential theoretical constructs in promoting technology adoption...
April 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28545844/rise-and-fall-of-the-two-visual-systems-theory
#11
Yves Rossetti, Laure Pisella, Robert D McIntosh
Among the many dissociations describing the visual system, the dual theory of two visual systems, respectively dedicated to perception and action, has yielded a lot of support. There are psychophysical, anatomical and neuropsychological arguments in favor of this theory. Several behavioral studies that used sensory and motor psychophysical parameters observed differences between perceptive and motor responses. The anatomical network of the visual system in the non-human primate was very readily organized according to two major pathways, dorsal and ventral...
May 23, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28542167/corticosterone-oscillations-during-mania-induction-in-the-lateral-hypothalamic-kindled-rat-experimental-observations-and-mathematical-modeling
#12
Osama A Abulseoud, Man Choi Ho, Doo-Sup Choi, Ana Stanojević, Željko Čupić, Ljiljana Kolar-Anić, Vladana Vukojević
Changes in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled (LHK) rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK...
2017: PloS One
https://www.readbyqxmd.com/read/28532982/maternal-and-paternal-physical-abuse-unique-and-joint-associations-with-child-behavioral-problems
#13
Naixue Cui, Janet A Deatrick, Jianghong Liu
Although there is a substantial amount of literature documenting the relationship between child abuse and behavioral problems in China, there is, on the other hand, a limited number of studies on the joint and unique associations of maternal and paternal physical abuse with child behaviors within the Chinese context. The present study, using the family systems theory as the theoretical framework, aims to examine these joint and the unique associations of maternal and paternal physical abuse with externalizing and internalizing behaviors among a community sample of Chinese children...
May 19, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28528276/a-review-of-neighborhood-effects-and-early-child-development-how-where-and-for-whom-do-neighborhoods-matter
#14
REVIEW
Anita Minh, Nazeem Muhajarine, Magdalena Janus, Marni Brownell, Martin Guhn
This paper describes a scoping review of 42 studies of neighborhood effects on developmental health for children ages 0-6, published between 2009 and 2014. It focuses on three themes: (1) theoretical mechanisms that drive early childhood development, i.e. how neighborhoods matter for early childhood development; (2) dependence of such mechanisms on place-based characteristics i.e. where neighborhood effects occur; (3) dependence of such mechanisms on child characteristics, i.e. for whom is development most affected...
May 18, 2017: Health & Place
https://www.readbyqxmd.com/read/28528256/evaluation-of-artificial-time-series-microarray-data-for-dynamic-gene-regulatory-network-inference
#15
P Xenitidis, I Seimenis, S Kakolyris, A Adamopoulos
High-throughput technology like microarrays is widely used in the inference of gene regulatory networks (GRNs). We focused on time series data since we are interested in the dynamics of GRNs and the identification of dynamic networks. We evaluated the amount of information that exists in artificial time series microarray data and the ability of an inference process to produce accurate models based on them. We used dynamic artificial gene regulatory networks in order to create artificial microarray data. Key features that characterize microarray data such as the time separation of directly triggered genes, the percentage of directly triggered genes and the triggering function type were altered in order to reveal the limits that are imposed by the nature of microarray data on the inference process...
May 17, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28490324/the-experiences-of-attempt-survivor-families-and-how-they-cope-after-a-suicide-attempt-in-ghana-a-qualitative-study
#16
Winifred Asare-Doku, Joseph Osafo, Charity S Akotia
BACKGROUND: Ghana's socio-cultural landscape proscribes suicidal behaviour, and this has serious ramifications for attempt survivors and their families. The objective of this qualitative study was to understand the experiences of the families of attempt survivors and how they cope with the aftermath of the attempt. METHODS: Ten families with attempted suicides agreed to participate in the study, hence they were interviewed. The information gathered was manually analyzed according to Interpretative Phenomenological Analysis (IPA) resulting in three major thematic areas...
May 11, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28488814/iphos-pseevo-identifying-human-phosphorylated-proteins-by-incorporating-evolutionary-information-into-general-pseaac-via-grey-system-theory
#17
Wang-Ren Qiu, Bi-Qian Sun, Xuan Xiao, Dong Xu, Kuo-Chen Chou
Protein phosphorylation plays a critical role in human body by altering the structural conformation of a protein, causing it to become activated/deactivated, or functional modification. Given an uncharacterized protein sequence, can we predict whether it may be phosphorylated or may not? This is no doubt a very meaningful problem for both basic research and drug development. Unfortunately, to our best knowledge, so far no high throughput bioinformatics tool whatsoever has been developed to address such a very basic but important problem due to its extremely complexity and lacking sufficient training data...
May 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28475664/dynamical-resilience-indicators-in-time-series-of-self-rated-health-correspond-to-frailty-levels-in-older-adults
#18
Sanne M W Gijzel, Ingrid A van de Leemput, Marten Scheffer, Mattia Roppolo, Marcel G M Olde Rikkert, René J F Melis
Background: We currently still lack valid methods to dynamically measure resilience for stressors before the appearance of adverse health outcomes that hamper well-being. Quantifying an older adult's resilience in an early stage would aid complex decision-making in health care. Translating complex dynamical systems theory to humans, we hypothesized that three dynamical indicators of resilience (variance, temporal autocorrelation, and cross-correlation) in time series of self-rated physical, mental, and social health were associated with frailty levels in older adults...
July 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28471258/developing-interprofessional-education-online-an-ecological-systems-theory-analysis
#19
Patricia Bluteau, Lynn Clouder, Debra Cureton
This article relates the findings of a discourse analysis of an online asynchronous interprofessional learning initiative involving two UK universities. The impact of the initiative is traced over three intensive periods of online interaction, each of several-weeks duration occurring over a three-year period, through an analysis of a random sample of discussion forum threads. The corpus of rich data drawn from the forums is interpreted using ecological systems theory, which highlights the complexity of interaction of individual, social and cultural elements...
May 4, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28460149/the-parented-outline-for-observing-hospitalized-pediatric-patients-and-their-families
#20
Amy L Tremain
The PARENTED outline (a mnemonic device) and the companion Parenting Landscape handout are proposed tools for clinical use that were developed as an outgrowth of clinical experience with hospitalized pediatric mental health patients and their families in combination with family systems theories of Minuchin and Bowen, Ainsworth and Bowlby's attachment theory, and Erikson's stages of development. The tools contain eight categories of observable, typical family interactions that a nurse on an inpatient mental health unit may encounter...
May 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
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