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Iodine deficiency

Julia Elisabeth von Oettingen, Tesha Dawn Brathwaite, Christopher Carpenter, Ric Bonnell, Xuemei He, Lewis E Braverman, Elizabeth N Pearce, Philippe Larco, Nancy Charles Larco, Eddy Jean-Baptiste, Rosalind S Brown
CONTEXT: Iodine deficiency is the leading cause of preventable neurodevelopmental delay in children worldwide. It is a possible public health concern in Haiti. OBJECTIVE: To perform a population iodine survey in Haitian young children, and its influence by environmental factors. DESIGN: Cross-sectional study, March-June 2015. SETTING: Community churches in 3 geographical regions in Haiti. PARTICIPANTS: 299 healthy Haitian children aged 9 months to 6 years; 100 enrolled in coastal (C) and mountainous (M) regions, and 99 in an urban region (U)...
October 21, 2016: Journal of Clinical Endocrinology and Metabolism
Sarah C Bath, Victor J M Pop, Victoria L Furmidge-Owen, Maarten Broeren, Margaret P Rayman
Background Though iodine deficiency in pregnancy is a matter of public-health concern, a functional measure of iodine status is lacking. The thyroid-specific protein, thyroglobulin (Tg), which reflects thyroid size, has shown promise as a functional measure in studies of children and adults, but data in pregnancy are sparse. In a cohort of mildly-to-moderately iodine-deficient pregnant women, we aimed to explore whether serum Tg is a sensitive functional biomarker of iodine status and to examine longitudinal change in Tg with gestational age...
October 20, 2016: Thyroid: Official Journal of the American Thyroid Association
Masaharu Tsubokura, Shuhei Nomura, Hajime Watanobe, Yoshitaka Nishikawa, Chiaki Suzuki, Sae Ochi, Claire Leppold, Hirokatsu Kinoshita, Shigeaki Kato, Yasutoshi Saito
Background Iodine deficiency is an important modifier of the risk of thyroid cancer following irradiation; however, little information is available on a prevalence of iodine deficiency in Fukushima and its surroundings after the Fukushima Daiichi nuclear power plant accident that occurred in March, 2011. Methods To assess urinary iodine concentrations (UIC) and a prevalence of iodine deficiency and to elucidate any associations between demographic characteristics and UIC levels among children and adolescents aged 18 or younger at the time of the accident in Fukushima Prefecture and its surroundings, we evaluated the data on voluntary UIC testing conducted by Hirata Central Hospital, Fukushima...
October 19, 2016: Thyroid: Official Journal of the American Thyroid Association
Rut Anne Thomassen, Janne Anita Kvammen, Mari Borge Eskerud, Pétur Benedikt Júlíusson, Christine Henriksen, Jarle Rugtveit
OBJECTIVES: To investigate iodine status and growth in cow's milk protein allergic infants and to identify potential predictors of iodine status and growth. METHODS: Fifty-seven infants under two years of age were included in an observational cross-sectional study. Two spot urine samples were collected and analysed for iodine, together with a three-day food record and a food frequency questionnaire. Urine iodine concentrations were compared to the WHO cut-off values for iodine deficiency...
October 12, 2016: Journal of Pediatric Gastroenterology and Nutrition
Michela Marina, Gian Paolo Ceda, Raffaella Aldigeri, Graziano Ceresini
To evaluate the causes of the first referral to an endocrine visit of patients with thyroid cancer in a mildly iodine-deficient area and to correlate them with prognostic features. We studied 298 consecutive patients (64 M and 234 F) with thyroid cancer. Of these, 281 had differentiated thyroid cancer. The causes of referral were categorized as follows: (Group A) clinical evidence of a neck lump; (Group B) incidental imaging in subjects without known thyroid diseases; (Group C) incidental imaging during a workup of thyroid disorders...
October 14, 2016: Endocrine
Lydie Ryšavá, Jaroslav Kříž
Diseases caused by Iodine deficit are preventable. Inter resort Commission for the solution of Iodine deficiency (MKJD) at State Institute for Health (SZU) in Prague has been taking effective measures which satisfied requirements of the Principles for sustainable elimination of diseases caused by Iodine deficiency ICCD WHO: 96 % of households is using iodized salt, average Iodine content is 25 mg/1 kg of salt. Data from studies show ioduria less 100 mcg/l in only 9 per cent of seniors, 5 % of children 7-10 years, 3 % of children 10-12 years...
2016: Vnitr̆ní Lékar̆ství
Michala Vosátková, Denisa Janíčková Žďarská, Václav Zamrazil, Martina Salátová, Martin Hill, Karel Vondra
INTRODUCTION: In patients with type 1 and 2 diabetes mellitus only rare data concerning the status of iodine supplementation and impact of possible iodine deficiency is available. AIM: To get basic information about (a) state of supply with iodine in patients with type 1 diabetes mellitus (DM1T), (b) the difference from non-diabetic population, (c) possible association of iodine saturation with some clinical and laboratory features of the diabetic syndrome, including the state of thyroid gland...
2016: Vnitr̆ní Lékar̆ství
Lydie Ryšavá, Jaroslav Kříž, Lucie Kašparová, Tereza Křížová, Monika Žoltá, Petra Lisníková
Monitoring of Ioduria and Iodine saturation are essential tools for evaluation of effectivness of measures aimed at elimination of diseases caused by iodine deficiency. Between 1995 and 2016 monitoring of ioduria was udertaken in various population groups in Czech Republic. The most recent study (2015) found only 37 % of pregnant women in optimal range of ioduria (150-300 mcg/l), in iodopenic range 27 %, while 6 % of these had severe iodopenia below 50 mcg/l. In a group of 3y old children investigated in the same year, 57 % were found to have Ioduria within the recommended range (90-299 mcg/l), 24 % had higher than recommended Ioduria (300-499 mcg/l) and 8 % excessive saturation (over 500 mcg/l)...
2016: Vnitr̆ní Lékar̆ství
Radovan Bílek, Nataša Kaňová, Veronika Mindžáková, David Neumann, Jan Jiskra, Lydie Ryšavá, Václav Zamrazil
INTRODUCTION: Iodine deficiency is a global public health problem which is particularly noticeable in pregnant or breastfeeding women and their children. Even mild iodine deficiency during pregnancy can lead to damage to the developing brain and thus affecting the fetus intelligence, his cognitive and neurological function, embryogenesis and growth. PATIENTS: In the period 2010-2015 was determined by spectrophotometry at the Institute of Endocrinology the basal urinary iodine in 532 pregnant women at the age of 32 ± 5 (18-44) years, which came from Prague, Hradec Kralove and Mlada Boleslav...
2016: Vnitr̆ní Lékar̆ství
Sara Stinca, Maria Andersson, Sandra Weibel, Isabelle Aeberli-Herter, Ralph Fingerhut, Sueppong Gowachirapant, Sonja Y Hess, Nidhi Jaiswal, Tomislav Jukić, Zvonko Kusic, Ngoako Solomon Mabapa, Ashwini Kumar Nepal, Teofilo O L San Luis, Jia Qing Zhen, Michael Bruce Zimmermann
CONTEXT: Thyroglobulin (Tg) may be a sensitive biomarker of iodine nutrition in pregnant women (PW). A dried blood spot (DBS) assay would simplify collection and transport in field studies. OBJECTIVES: Our aims were to: 1) establish a reference range for DBS-Tg in iodine-sufficient PW; 2) test this reference range in PW with a range of iodine intakes; and 3) determine if co-measurement of Tg antibodies (Ab) is necessary to define population iodine status. Design, Settings and Participants: Standardized cross-sectional studies in 3870 PW from 11 countries with iodine intakes from deficient to more-than-adequate...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
Kostja Renko, Carolin S Hoefig, Corinne Dupuy, Lisbeth Harder, Christian Schwiebert, Josef Köhrle, Lutz Schomburg
Iodotyrosine deiodinase (DEHAL1) is a crucial enzyme in iodine homeostasis. Unbound mono- and diiodotyrosines are indispensable byproducts of thyroid hormone biosynthesis. Their iodine needs to be recovered to avoid iodine deficiency, as observed in genetic defects in DEHAL1. Despite its importance, the enzyme is rarely studied. The deiodination process can be monitored by radioactive tracers or via techniques involving mass spectrometry (MS). However, isotope-labeled molecules are expensive, not always commercially available, and their use is legally restricted, while MS requires sophisticated, costly and sensitive instrumentation...
October 12, 2016: Endocrinology
Eric De Zoysa, Manjula Hettiarachchi, Chandrani Liyanage
BACKGROUND: Iodine deficiency and thyroid dysfunction during pregnancy is associated with number of adverse outcomes that includes mental and physical disabilities creating a huge human and economic burden in later life. Several indicators are used to assess the iodine status of a population: thyroid size by palpation and/or by ultrasonography, urinary iodine excretion and the blood thyroid hormone profile. METHODS: This prospective study was designed to assess the iodine nutrition during the course of pregnancy with reference to urine iodine concentration (UIC) and thyroid determinants among 425 pregnant women from Galle district, Sri Lanka...
October 12, 2016: BMC Pregnancy and Childbirth
Huseyin Kurku, Ali Gencer, Ozgur Pirgon, Muammer Buyukinan, Nagehan Aslan
BACKGROUND: Iodine is a part of thyroid hormones and has been reported to act directly as an antioxidant or induce indirectly antioxidant enzymes. This study aimed to assess the urinary iodine concentration and its relationship between the antioxidant and oxidative stress capacity in healthy school-aged children. METHODS: In total, 196 students from five primary schools, randomly selected between 9 and 12 years (mean age: 10.2±1.2 years), were enrolled in the study...
October 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Dariusz Janczak, Wiktor Pawlowski, Tadeusz Dorobisz, Dawid Janczak, Karolina Dorobisz, Michal Leśniak, Agnieszka Ziomek, Mariusz Chabowski
BACKGROUND: Thyroid cancer (TC) comprises 1% of all carcinomas and is the most common malignancy of the endocrine system. The disease is more common in women, with its peak morbidity observed in 40-50-year-old patients. The main risk factors include radiation, iodine deficiency, hereditary background, and genetic mutations. Among all diagnosed thyroid nodules, 5%-30% will evolve into cancer. The gold-standard procedure in the preoperative evaluation of a nodular goiter, apart from ultrasonography, is fine needle aspiration (FNA) biopsy...
2016: OncoTargets and Therapy
Tippawan Pongcharoen, Sueppong Gowachirapant, Purisa Wecharak, Natnaree Sangket, Pattanee Winichagoon
BACKGROUND AND OBJECTIVES: Maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) have been reported to be associated with pregnancy outcomes. Due to the nutrition transition in Thailand, the double burden of malnutrition is increasing and this may have negative consequences on birth outcomes. This study aimed to investigate the relationship between pre-pregnancy BMI and GWG with the risks of low birth weight and macrosomia. METHODS AND STUDY DESIGN: We performed a secondary analysis of data obtained from an iodine supplementation trial in mildly iodine-deficient Thai pregnant women...
December 2016: Asia Pacific Journal of Clinical Nutrition
Nunzia Brusca, Camilla Virili, Miriam Cellini, Silvia Capriello, Lucilla Gargano, Rita Salvatori, Marco Centanni, Maria Giulia Santaguida
OBJECTIVE: Autonomously functioning thyroid areas may be associated with subclinical or overt hyperthyroidism, but may exist even in the presence of normal TSH. This study was aimed at comparing the rate of autonomously functioning areas and their cardiac sequelae in patients with nodular goitre studied with the usual and a novel approach. DESIGN AND METHODS: A total of 490 adult outpatients with thyroid nodular goitre, living in a mild iodine-deficient area, were selected in our Referral Center for thyroid diseases from 2009 to 2014 on the basis of a suspicion of thyroid functional autonomy...
September 19, 2016: European Journal of Endocrinology
Luca Giovanella, Federica D'Aurizio, Alfredo Campenni', Rosaria Maddalena Ruggeri, Sergio Baldari, Frederik Anton Verburg, Pierpaolo Trimboli, Luca Ceriani
The purpose of this study is to evaluate the distribution of thyrotropin (TSH) values in patients with autonomously functioning thyroid nodules and to set a TSH threshold above which thyroid scintigraphy would be obviated. Four hundred fifty one patients were included in the present study. Inclusion criteria were age > 18 years, TSH levels between 0.40 and 4.0 mIU/L, detection of a single solid or predominantly solid thyroid nodule >10 mm in the longest diameter. Thyroid ultrasound and thyroid scintigraphy with (99m)Tc-pertechnetate were performed concurrently in all patients...
September 15, 2016: Endocrine
J E C Santos, M Freitas, C P Fonseca, P Castilho, I M Carreira, J L Rombeau, M C Branco
BACKGROUND: The goal of eliminating iodine deficiency (ID) by the year 2000 has still not been achieved in several countries. More than 2 billion people worldwide (over 260 million school age children) remain ID. In Europe, there are still countries, such as Portugal, without national general population data on iodine nutrition (IN). This study aims at evaluating combined complementary data of the IN of the general population through urinary iodine concentration (UIC) and the thyroid histology profile from the inland region of Beira Interior (BI), in Portugal...
September 12, 2016: Journal of Endocrinological Investigation
Julia K Mack, Ellen Kienzle
: Anamnesis: A litter of Bernese Mountain Dog-puppies (6 weeks of age) was meant to be fed a "BARF" (bones and raw food) diet. The breeder asked for advice regarding the nutritional adequacy of the feeding plans that she had compiled for the different growth stages. The anamnesis showed the puppies to be underweight for their age and expected adult body mass at the time of request for a ration check. The bitch had almost stopped lactating. Ration check: The review of the feeding plans for the different growth stages revealed a deficient energy supply for all stages and at times an inadequate protein supply...
October 12, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Serhat Uysal, Varol Tunalı, Eylem Akdur Öztürk, Ömür Ardeniz, Meltem Işıkgöz Taşbakan, Hüsnü Pullukçu, Seray Özensoy Töz, Nevin Turgay, Bilgin Arda
OBJECTIVE: Parasites might cause atypical and severe infections in immunocompromised hosts. The prevalence of diarrhea among common variable immune deficiency (CVID) syndrome patients varies between 20% and 94%, which indicates that diarrhea and gastrointestinal system (GIS) complaints could be the second leading cause of morbidity in CVID patients after respiratory tract infections. This study aimed to assess the prevalence of intestinal parasites in CVID patients with GIS complaints and diarrhea...
June 2016: Türkiye Parazitolojii Dergisi
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