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Masayuki Kurokawa, Sei Naito, Osamu Ichiyanagi, Takanobu Kabasawa, Yuta Kurota, Toshihiko Sakurai, Hayato Nishida, Hisashi Kawazoe, Tomoyuki Kato, Akira Nagaoka, Mitsunori Yamakawa, Norihiko Tsuchiya
Interstitial lung disease (ILD) is a common side effect of the mechanistic target of rapamycin inhibitor everolimus. Most cases of everolimus-induced ILD are mild and reversible. As per guidelines, even if Common Terminology Criteria for Adverse Events grade 1 or 2 everolimus-induced ILD occurs, either continuation of everolimus without dose reduction or readministration at a low dose is possible. However, the pathophysiology of everolimus-induced ILD is unknown. We present a case of everolimus-induced ILD with spontaneous remission during treatment in a patient with metastatic renal cell carcinoma...
September 2017: Hinyokika Kiyo. Acta Urologica Japonica
Ian J Saldanha, Oluwaseun Akinyede, Karen A Robinson
BACKGROUND: For people with cystic fibrosis and advanced pulmonary damage, lung transplantation is an available and viable option. However, graft rejection is an important potential consequence after lung transplantation. Immunosuppressive therapy is needed to prevent episodes of graft rejection and thus subsequently reduce morbidity and mortality in this population. There are a number of classes of immunosuppressive drugs which act on different components of the immune system. There is considerable variability in the use of immunosuppressive agents after lung transplantation in cystic fibrosis...
2015: Cochrane Database of Systematic Reviews
I L Klyachkina
Acute cough associated with influenza and acute respiratory viral infection (ARVI) is one of the most common complaints prompting the patient to visit a general practitioner or an otorhinolaryngologist based at the outpatient clinic. Acute cough during ARVI in the practically healthy subjects is as a rule non-productive, frequently dry, and becomes resolved within 2-3 weeks. In certain cases, however, the cough during ARVI can be productive with the well apparent abnormal expectoration of sputum especially in the aged and elderly subjects, young children, and patients suffering from the chest injuries, dry pleuritis, and other disorders...
2015: Vestnik Otorinolaringologii
Dilek Azkur, Eda Özaydın, Emine Dibek-Mısırlıoğlu, Emine Vezir, Duygu Tombuloğlu, Gülşen Köse, Can N Kocabaş
Acute bronchiolitis is predominantly a viral disease. Respiratory syncytial virus is the most common agent, but other newly identified viruses have also been considered as causes. The aim of the present study is to determine the respiratory viruses causing acute bronchiolitis in hospitalized infants. Infants younger than 2 years of age who were hospitalized for acute viral bronchiolitis in a children's hospital between November 2011 and May 2012 were evaluated for the presence of viruses as etiologic agents using a realtime polymerase chain reaction method...
November 2014: Turkish Journal of Pediatrics
Kiruba Vembu, Vijaya Sivaling Ramalingam, Andreea Antonescu-Turcu
SESSION TITLE: Infectious Disease Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: The differential diagnosis for immunocompromised patients presenting with pulmonary infiltrates is wide; both non-infectious causes, such as drug-related or pulmonary hemorrhage, should be considered in addition to infectious etiologies, including atypical bacteria, viruses and fungi. CASE PRESENTATION: A 64 year old male with past medical history significant for renal transplant performed in 2009 reported to the ED complaining of fever and cough productive of yellow sputum...
October 1, 2014: Chest
Ian J Saldanha, Oluwaseun Akinyede, Naomi A McKoy, Karen A Robinson
BACKGROUND: For patients with cystic fibrosis and advanced pulmonary damage, lung transplantation is an available and viable option. However, graft rejection is an important potential consequence after lung transplantation. Immunosuppressive therapy is needed to prevent episodes of graft rejection and thus subsequently reduce morbidity and mortality in this population. There are a number of classes of immunosuppressive drugs which act on different components of the immune system. There is considerable variability in the use of immunosuppressive agents after lung transplantation in cystic fibrosis...
2013: Cochrane Database of Systematic Reviews
Suset Oropeza Fernández, Belsy Acosta Herrera, Alexander Piñón Ramos, Odalys Valdés Ramírez, Clara Savón Valdés, Amely Arencibia García, Elias Guilarte García, Grehete González Muñoz, Angel Goyenechea Hernández, Mayra Muné Jiménez, Guelsys González Báez, Bárbara Hernández Espinosa, María G Guzmán Tirado, Alina Llop Hernández
INTRODUCTION: the first pandemic virus of the 21st century - the influenza A (H1N1)/2009 virus-appeared in Mexico in April 2009 after triple reassortment of influenza strains of avian, human and pig origin and from there, it was spread worldwide. With the purpose of facing up to this event, Cuba adopted antipandemic measures including the virology surveillance using all necessary actions. OBJECTIVES: the detection and validation of the entry of the causative agent of pandemic into the country in a fast and timely way, in addition to the definition of involvement of other viruses in the etiology of acute respiratory infections...
May 2011: Revista Cubana de Medicina Tropical
Maria Jose Santana, David Feeny, Sunita Ghosh, Dale C Lien
PURPOSE: Transplantation has the potential to produce profound effects on survival and health-related quality of life (HRQL). The inclusion of the patient's perspective may play an important role in the assessment of the effectiveness of lung transplantation. Patient perspectives are assessed by patient-reported outcome measures, including HRQL measures. We describe how patients' HRQL among different diagnosis groups can be used by clinicians to monitor and evaluate the outcomes associated with transplantation...
2012: Patient related Outcome Measures
Kristine L Bucasas, Asad I Mian, Gail J Demmler-Harrison, Alison C Caviness, Pedro A Piedra, Luis M Franco, Chad A Shaw, Yijie Zhai, Xueqing Wang, Molly S Bray, Robert B Couch, John W Belmont
BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of pediatric lower respiratory tract infections and has a high impact on pediatric emergency department utilization. Variation in host response may influence the pathogenesis and disease severity. We evaluated global gene expression profiles to better understand the systemic host response to acute RSV bronchiolitis in infants and young children. METHODS: Patients (age ≤ 24 months) who were clinically diagnosed with acute bronchiolitis and who had a positive rapid test for RSV assay were recruited from the Texas Children's Hospital emergency department...
February 2013: Pediatric Infectious Disease Journal
Anna Breborowicz
Broncholitis in infant is most commonly results from viral infection, typically RS virus will be responsible. Treatment is difficult due to limited efficacy of available methods of causal and symptomatic therapies. Therefore it is specially important to seek preventive measures. This is crucial in case of preterm infants, infants with broncho-pulmonary dysplasia, cystic fibrosis, hemodynamically significant congenital heart defects and immunodeficiencies who are likely to undergo a severe course of the disease...
2011: Przegla̧d Lekarski
Renée N Douville, Yuriy Lissitsyn, Aaron F Hirschfeld, Allan B Becker, Anita L Kozyrskyj, Joel Liem, Nathalie Bastien, Yan Li, Rachel E Victor, Mehtab Sekhon, Stuart E Turvey, Kent T HayGlass
BACKGROUND: A broad variety of natural environmental stimuli, genotypic influences and timing all contribute to expression of protective versus maladaptive immune responses and the resulting clinical outcomes in humans. The role of commonly co-segregating Toll-like receptor 4 (TLR4) non-synonymous single nucleotide polymorphisms Asp299Gly and Thr399Ile in this process remains highly controversial. Moreover, what differential impact these polymorphisms might have in at risk populations with respiratory dysfunction, such as current asthma or a history of infantile bronchiolitis, has never been examined...
August 10, 2010: PloS One
Patrizio Pezzotti, Jessica Mantovani, Nicoletta Benincori, Eleonora Mucchino, Domenico Di Lallo
BACKGROUND: Bronchiolitis is a distressing, potentially life-threatening respiratory condition that affects infants. We evaluated the incidence and risk factors of hospitalization for broncholitis in preterm infants (i.e., a gestational age of <36 weeks) born between 2000 and 2006, and the use and impact of Palivizumab, a monoclonal antibody that in randomized clinical trials has been shown to lessen the severity of RSV-related bronchiolitis. METHODS: Retrospective cohort study that linked data from four health administrative databases in the Lazio region (a region of central Italy): the birth register, the hospital discharge register, and two ad-hoc databases that record the doses of Palivizumab administered at two local health units...
2009: BMC Pediatrics
Ankit Bharat, Elbert Kuo, Nancy Steward, Aviva Aloush, Ramsey Hachem, Elbert P Trulock, G Alexander Patterson, Bryan F Meyers, T Mohanakumar
BACKGROUND: Primary graft dysfunction (PGD) in the immediate post-lung transplant period strongly increases the risk of chronic rejection (broncholitis obliterans syndrome). Here, we hypothesized that PGD-induced inflammation augments alloimmunity, thereby predisposing to broncholitis obliterans syndrome. METHODS: Primary graft dysfunction and broncholitis obliterans syndrome were diagnosed according to the established International Society for Heart and Lung Transplantation criteria...
July 2008: Annals of Thoracic Surgery
Elamin M Elamin, Mansura Ghani, Jeremiah S Reedy, Larry F Hughes, Faisal Khan, Omer Khalid, Diane Drew et al.
BACKGROUND: Tracheal dyskinesia (TD) was recently recognized as a possible mechanism for acute pulmonary edema (Elamin and Firdose, J Bronchol 2004;11:118-21; Khan and Elamin Eur Respir J 2005;26:319). This study was designed to evaluate possible impact of TD on cardiac hemodynamics. METHODS: Patients were prospectively assigned to either study "A" or control "B" groups (TD >50% or <50%, respectively) diagnosed by bronchoscopy or dynamic chest computed tomography...
May 2008: American Journal of the Medical Sciences
Antoine Bourrillon
Clinical criteria used to define acute broncholitis in infants are not worldwide consensual diagnostic criteria. Respiratory failures as well as young age account for the severity of the disease. Laboratory analyses are useless in community medical practice. Infectious complications are due to secondary infection with usual respiratory pathogenic bacteria. In France the treatment mainly consists in physical therapy whose efficiency is currently being evaluated by randomized studies. Prevention of the disease relies on hygiene measures and in an integrated physician-physiotherapist collaboration...
November 15, 2007: La Revue du Praticien
Verena Bröcker, Ulrich Lehmann, Florian Länger, Tariq G Fellous, Michael Mengel, Mairi Brittan, Martin Bredt, Simone Milde, Tobias Welte, Matthias Eder, Axel Haverich, Malcolm R Alison, Hans Kreipe
RATIONALE: The participation of circulating precursor cells in the development of experimental pulmonary fibrosing lesions in mice has been recently demonstrated. OBJECTIVES: This study analyzes whether circulating, bone marrow-derived fibroblastic precursor cells contribute to the development of fibrosing lesions in human lungs, especially bronchiolitis obliterans. METHODS: The occurrence of in situ-microchimerism in bronchiolitis obliterans lesions of human lung allografts (n = 12) as well as of autologous lung tissue from patients post bone marrow-transplantation (n = 2) was analyzed using laser-assisted microdissection after immunohistochemical labeling of leukocytes followed by STR-PCR-based genotyping...
2006: Verhandlungen der Deutschen Gesellschaft Für Pathologie
Carlos Ochoa Sangrador, M Verisima Barajas Sánchez, Beatriz Muñoz Martín
Child day-care attendance is considered to be an acute early childhood disease risk factor, the studies available however not affording the possibility of fully quantifying this risk. A systematic review of clinical trials and cohort studies was conducted, in which the effects child day-care attendance had on the health of young children based on the Cochrane Collaboration, PubMed and Spanish Medical Index databases, without any time or language-related limits, were analyzed and rounded out with analyses of referenced works and an additional EMBASE search...
March 2007: Revista Española de Salud Pública
Laurie D Snyder, Matthew G Hartwig, Tonya Ganous, R Duane Davis, Walter F Herczyk, Nancy L Reinsmoen, David A Schwartz, Scott M Palmer
BACKGROUND: Cytokine polymorphisms are inconsistently associated with transplant rejection and other adverse outcomes. To address this controversy, we evaluated cytokine single nucleotide polymorphisms (SNPs) in a lung transplant cohort. METHODS: All patients who underwent lung transplantation from 1993 to 1998 and had post-transplant survival of at least 6 months were included in the initial analysis. Subjects were genotyped for: TNF-alpha -308 G/A; IFN-gamma +874 A/T; TGF-beta1 +869 T/C and +915 G/C; IL-10 -1082 A/G, -819 C/T and -592 C/A; and IL-6 -174 G/C...
November 2006: Journal of Heart and Lung Transplantation
Waheeb Sakran, Hassan Makary, Raul Colodner, Dror Ashkenazi, Yoseph Rakover, Raphael Halevy, Ariel Koren
OBJECTIVE: Acute otitis media (AOM) in the neonatal period can be difficult to diagnose. This infection can be isolated and localized, or it may be associated with serious bacterial infections or other illnesses. The objectives of this study were to determine the clinical presentation, etiology, susceptibility pattern, and frequency of bacteremia, meningitis and other serious bacterial infections associated with the first episode of AOM in young infants. METHODS: From July 2002 to August 2004, infants less than 12 weeks of age with confirmed AOM underwent tympanocentesis with culture of the middle ear fluid...
April 2006: International Journal of Pediatric Otorhinolaryngology
Raymond Farah, Eleonora Vaisban, Ronit Geron, Hector Cohen, Faris Nassar
In this unusual case, we report the history of a patient who was hospitalized with pulmonary manifestations presenting as broncholitis obliterance organizing pneumonia (BOOP) associated with ANCA-negative pauci-immune glomerulonephritis. Other known causes for the occurrence of BOOP were excluded. Immediate diagnosis and treatment with a combination of steroids and cytotoxic therapy resulted in a complete remission and prevented eventual dialysis.
February 2005: European Journal of Internal Medicine
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