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JOURNAL ARTICLE
Prashant Mahajan, Joseph A Grubenhoff, Jim Cranford, Maala Bhatt, James M Chamberlain, Todd Chang, Mark Lyttle, Rianne Oostenbrink, Damian Roland, Richard M Rudy, Kathy N Shaw, Robert Velasco Zuniga, Apoorva Belle, Nathan Kuppermann, Hardeep Singh
BACKGROUND: Diagnostic errors, reframed as missed opportunities for improving diagnosis (MOIDs), are poorly understood in the paediatric emergency department (ED) setting. We investigated the clinical experience, harm and contributing factors related to MOIDs reported by physicians working in paediatric EDs. METHODS: We developed a web-based survey in which physicians participating in the international Paediatric Emergency Research Network representing five out of six WHO regions, described examples of MOIDs involving their own or a colleague's patients...
March 2023: BMJ Open Quality
#22
MULTICENTER STUDY
Daniel Camprubí-Ferrer, Ludovico Cobuccio, Steven Van Den Broucke, Leire Balerdi-Sarasola, Blaise Genton, Emmanuel Bottieau, Jessica Navero-Castillejos, Miguel J Martinez, Corinne Jay, Anne Grange, Stéphanie Borland, Mike Vaughn, Natalia Rodriguez-Valero, Alex Almuedo-Riera, Valérie D'Acremont, Carme Subirà, Tessa de Alba, Angeline Cruz, Marjan Van Esbroeck, Crystal Smith, Ashley Hillman, Brandon Hanberg, Rob Trauscht, Nerissa Spampanato, Jose Muñoz
BACKGROUND: Identifying the causes of Acute Undifferentiated Febrile Illness (AUFI) is key to improve the management of returning travellers with fever. We evaluated a BioFire®FilmArray® prototype panel of multiplex nucleic acid amplification tests (NAAT) targeting different relevant pathogens in travellers returning with fever. METHODS: Prospective, multicentre study to evaluate a prototype panel in whole blood samples of adult international travellers presenting with AUFI in three European travel Clinics/Hospitals (November 2017-November 2019)...
May 18, 2023: Journal of Travel Medicine
#23
EDITORIAL
Vibhor Agrawal, Sahil Chaudhary, Saurabh Pandey
Kanpur, India, recently witnessed an outbreak of undifferentiated febrile illness among medical students. Several students developed high-grade fever with altered sensorium within 2-3 days after the index case. Surprisingly, this outbreak coincided with the death of several pigs in the vicinity. Acute necrotising encephalitis, although rare, was noted in some patients. When correlated with each other, all of these incidents were suggestive of an outbreak of H1N1.
February 9, 2023: Tropical Doctor
#24
JOURNAL ARTICLE
Phanita Chankate, Thareerat Kalambaheti, Nathamon Kosoltanapiwat, Ampai Tanganuchitcharnchai, Stuart D Blacksell, Narisara Chantratita, Pornsawan Leaungwutiwong
Scrub typhus is a mite-borne disease caused by a Gram-negative obligately intracellular bacillus, Orientia tsutsugamushi . The disease is endemic in the Asia-Australia-Pacific region, including Thailand. Scrub typhus generally manifests as acute undifferentiated febrile fever along with myalgia, rash, and lymphadenopathy. An eschar can be a valuable diagnostic clue, but this skin lesion may be missed in some patients. The disease symptoms resemble those of other febrile illnesses such as leptospirosis, typhoid, murine typhus, malaria, and dengue fever, making a laboratory diagnosis necessary for the definitive diagnosis...
December 23, 2022: Tropical Medicine and Infectious Disease
#25
JOURNAL ARTICLE
Rahul Narang, Pradeep Deshmukh, Jyoti Jain, Manish Jain, Abhishek Raut, Vijayshri Deotale, Kiran Pote, Manju Rahi
BACKGROUND & OBJECTIVES: Scrub typhus caused by Orientia tsutsugamushi presents as acute undifferentiated fever and can be confused with other infectious causes of fever. We studied scrub typhus as part of a study on hospital-based surveillance of zoonotic and vector-borne zoonotic diseases at a tertiary care hospital located in the Wardha district, Maharashtra, India. We report here descriptive epidemiology and climatic factors affecting scrub typhus. METHODS: Patients of any age and sex with fever of ≥5 days were enrolled for this study...
January 2, 2023: Indian Journal of Medical Research
#26
JOURNAL ARTICLE
Juan Emmanuel Dewez, Lucy Pembrey, Ruud G Nijman, Stefano Del Torso, Zachi Grossman, Adamos Hadjipanayis, Diego Van Esso, Emma Lim, Marieke Emonts, James Burns, Christèle Gras-LeGuen, Daniela Kohlfuerst, Hans Jürgen Dornbusch, Karen Brengel-Pesce, Francois Mallet, Ulrich von Both, Maria Tsolia, Irini Eleftheriou, Dace Zavadska, Ronald de Groot, Michiel van der Flier, Henriëtte Moll, Nienke Hagedoorn, Dorine Borensztajn, Rianne Oostenbrink, Taco Kuijpers, Marko Pokorn, Katarina Vincek, Federico Martinón-Torres, Irene Rivero, Philipp Agyeman, Enitan D Carrol, Stéphane Paulus, Aubrey Cunnington, Jethro Herberg, Michael Levin, Aida Mujkić, Karin Geitmann, Liviana Da Dalt, Arūnas Valiulis, Risto Lapatto, Garyfallia Syridou, Péter Altorjai, Paul Torpiano, Ketil Størdal, Károly Illy, Artur Mazur, Mateja Vintar Spreitzer, Joana Rios, Corinne Wyder, Ivanna Romankevych, Romain Basmaci, Salvador Ibanez-Mico, Shunmay Yeung
BACKGROUND: Point-of-care-tests (POCTs) have been advocated to optimise care in patients with infections but their actual use varies. This study aimed to estimate the variability in the adoption of current POCTs by paediatricians across Europe, and to explore the determinants of variability. METHODS AND FINDINGS: A cross-sectional survey was conducted of hospital and primary care paediatricians, recruited through professional networks. Questions focused on the availability and use of currently available POCTs...
2022: PloS One
#27
JOURNAL ARTICLE
Agus Rachmat, Gerard C Kelly, Robert D Hontz, Chonthida Supaprom, Vireak Heang, Phireak Hip, Jose A Garcia-Rivera, Satharath Prom, Chhorvann Chhea, Ian W Sutherland, Karen S Corson, Andrew G Letizia
BACKGROUND: In 2020, the Kingdom of Cambodia experienced a nationwide outbreak of chikungunya virus (CHIKV). Despite an increase in the frequency of outbreaks and expanding geographic range of CHIKV, diagnostic challenges remain, and limited surveillance data of sufficient granularity are available to characterize epidemiological profiles and disease dynamics of the virus. METHODS: An ongoing and long-standing cross-sectional study of acute undifferentiated febrile illness (AUFI) in Cambodia was leveraged to describe the disease epidemiology and characterize the clinical presentation of patients diagnosed with CHIKV during the 2020 outbreak...
December 17, 2022: BMC Infectious Diseases
#28
JOURNAL ARTICLE
Kristine Mørch, Anand Manoharan, Sara Chandy, Ashita Singh, Cijoy Kuriakose, Suvarna Patil, Anil Henry, Novin Chacko, Gerardo Alvarez-Uria, Joel Nesaraj, Bjørn Blomberg, Siby Kurian, Christel Gill Haanshuus, George Vasanthan Antony, Nina Langeland, Dilip Mathai
BACKGROUND: Acute undifferentiated fever (AUF) ranges from self-limiting illness to life-threatening infections, such as sepsis, malaria, dengue, leptospirosis and rickettsioses. Similar clinical presentation challenges the clinical management. This study describes risk factors for death in patients hospitalized with AUF in India. METHODS: Patients aged ≥5 y admitted with fever for 2-14 d without localizing signs were included in a prospective observational study at seven hospitals in India during 2011-2012...
February 1, 2023: Transactions of the Royal Society of Tropical Medicine and Hygiene
#29
JOURNAL ARTICLE
Sangita D Kamath, Sarita Kumari, Ashok Sunder
Background and objective Scrub typhus (ST) is a rickettsial infection caused by Orientia tsutsugamushi , which is transmitted by the bite of the larval stage (chiggers) of trombiculid mites. Although it presents as an acute undifferentiated febrile illness (AUFI), its course can be complicated with acute respiratory distress syndrome, acute kidney injury (AKI), myocarditis, meningoencephalitis, hepatitis, multi-organ dysfunction syndrome (MODS), and ultimately death. This study aimed to evaluate the epidemiological features, clinical profile, laboratory features, and clinical outcomes of cases of scrub typhus and identify the predictors of disease severity...
July 2022: Curēus
#30
JOURNAL ARTICLE
False Positivity of Anti-SARS-CoV-2 Antibodies in Patients with Acute Tropical Diseases in Thailand.
Viravarn Luvira, Pornsawan Leaungwutiwong, Narin Thippornchai, Charin Thawornkuno, Supawat Chatchen, Wiwat Chancharoenthana, Sarunporn Tandhavanant, Sant Muangnoicharoen, Watcharapong Piyaphanee, Narisara Chantratita
Serology remains a useful indirect method of diagnosing tropical diseases, especially in dengue infection. However, the current literature regarding cross-reactivity between SARS-CoV-2 and dengue serology is limited and revealed conflicting results. As a means to uncover relevant serological insight involving antibody classes against SARS-CoV-2 and cross-reactivity, anti-SARS-CoV-2 IgA, IgM, and IgG ELISA, based on spike and nucleocapsid proteins, were selected for a fever-presenting tropical disease patient investigation...
July 12, 2022: Tropical Medicine and Infectious Disease
#31
Sadikshya Bhandari, Samikshya Bhandari, Kushal Gautam, Roshan Jha, Sijuka Devkota
Scrub typhus is an arthropod-borne fever that follows the bite of the larval form of Leptotrombidium mite carrying Orientia tsutsugamushi . It remains a serious health problem in the Asia-Pacific region. While it commonly presents as an undifferentiated fever with chills and an eschar, complications like pneumonitis, acute respiratory distress syndrome, disseminated intravascular coagulation, and meningoencephalitis may cause scrub typhus to be fatal. However, regardless of the dramatic presentation, treatment with antibiotics, preferably doxycycline or even azithromycin, is effective in recovery...
June 2022: Curēus
#32
JOURNAL ARTICLE
Tsheten Tsheten, Karma Lhendup, Thinley Dorji, Kinley Wangdi
Febrile illness is a common cause of hospital admission in developing countries, including Bhutan. Prolonged fever admission can add considerable strain on healthcare service delivery. Therefore, identifying the underlying cause of prolonged hospital stays can improve the quality of patient care by providing appropriate empirical treatment. Thus, the study's aims were to evaluate the aetiologies and factors of prolonged fever admission in Samtse Hospital, Bhutan. Fever admission data from 1 January to 31 December 2020 were retrieved from the Samtse Hospital database...
June 27, 2022: International Journal of Environmental Research and Public Health
#33
JOURNAL ARTICLE
Qi Peng, Xue Zhang, Jizong Li, Wenlong He, Baochao Fan, Yanxiu Ni, Maojun Liu, Bin Li
The porcine deltacoronavirus (PDCoV) is a newly discovered pig enteric coronavirus that can infect cells from various species. In Haiti, PDCoV infections in children with acute undifferentiated febrile fever were recently reported. Considering the great potential of inter-species transmission of PDCoV, we performed a comprehensive analysis of codon usage patterns and host adaptation profiles of 54 representative PDCoV strains with the spike (S) gene. Phylogenetic analysis of the PDCoV S gene indicates that the PDCoV strains can be divided into five genogroups...
May 8, 2022: Transboundary and Emerging Diseases
#34
JOURNAL ARTICLE
Hanh Thi Duc Tran, Christian Schindler, Thuy Thi Thanh Pham, Mai Quang Vien, Hung Manh Do, Quyet Thi Ngo, Trieu Bao Nguyen, Hang Thi Hai Hoang, Lan Thi Hoang Vu, Esther Schelling, Daniel H Paris
BACKGROUND: Dengue fever is highly endemic in Vietnam, but scrub typhus-although recognized as an endemic disease-remains underappreciated. These diseases together are likely to account for more than half of the acute undifferentiated fever burden in Vietnam. Scrub typhus (ST) is a bacterial disease requiring antimicrobial treatment, while dengue fever (DF) is of viral etiology and does not. The access to adequate diagnostics and the current understanding of empirical treatment strategies for both illnesses remain limited...
May 2022: PLoS Neglected Tropical Diseases
#35
JOURNAL ARTICLE
Anwitha Varmudy, Archana Sonawale, Vishal A Gupta, Niteen D Karnik
AIMS: Acute Respiratory Distress Syndrome (ARDS) is a known complication of acute febrile illness (AFI). The in-hospital mortality rate of ARDS is between 35-44%. Our study aimed to identify the different parameters that could be used to detect patients at higher risk of poor outcome in AFI complicated by ARDS. METHODS: 130 patients with AFI complicated by ARDS as per Berlin definition, admitted at the Medical Intensive Care Unit of Seth GS Medical College KEM Hospital Mumbai, were studied over a period of 18 months...
March 2022: Journal of the Association of Physicians of India
#36
JOURNAL ARTICLE
S S Nila, S K Paul, N Kobayashi, S A Nasreen, S Ahmed, F Ahamad, J Khanam, S Nahar, A A Sayeed, A M Al Amin
Rickettsial diseases are one of the leading causes of treatable acute febrile illness in Asia pacific region. This cross-sectional descriptive study was conducted at Department of Microbiology, Mymensingh Medical College to diagnose scrub typhus by rapid Immunochromatographic Test (ICT) and Nested PCR followed by molecular identification of possible Rickettsial coinfection among suspected febrile patients in Mymensingh, Bangladesh from March 2019 to February 2020. Among the enrolled 402 patients, 89 samples (22...
April 2022: Mymensingh Medical Journal: MMJ
#37
JOURNAL ARTICLE
Janith Warnasekara, Shalka Srimantha, Chamila Kappagoda, Dinesha Jayasundara, Indika Senevirathna, Michael Matthias, Suneth Agampodi, Joseph M Vinetz
BACKGROUND: Leptospirosis has globally significant human mortality and morbidity, yet estimating the clinical and public health burden of leptospirosis is challenging because timely diagnosis remains limited. The goal of the present study was to evaluate leptospirosis undercounting by current standard methods in both clinical and epidemiological study settings. METHODOLOGY/PRINCIPAL FINDINGS: A prospective hospital-based study was conducted in multiple hospitals in Sri Lanka from 2016 to 2019...
April 2022: PLoS Neglected Tropical Diseases
#38
JOURNAL ARTICLE
Demerise Johnston, Jill R Kelly, Michel Ledizet, Nathalie Lavoie, Robert P Smith, Jeffrey Parsonnet, Jonathan Schwab, John Stratidis, Scott Espich, Giyoung Lee, Kaitlin R Maciejewski, Yanhong Deng, Victoria Majam, Hong Zheng, Sougr-Nooma Bonkoungou, June Stevens, Sanjai Kumar, Peter J Krause
BACKGROUND: Borrelia miyamotoi is a relapsing fever spirochete that relatively recently has been reported to infect humans. It causes an acute undifferentiated febrile illness that can include meningoencephalitis and relapsing fever. Like Borrelia burgdorferi, it is transmitted by Ixodes scapularis ticks in the northeastern United States and by Ixodes pacificus ticks in the western United States. Despite reports of clinical cases from North America, Europe, and Asia, the prevalence, geographic range, and pattern of expansion of human B...
March 23, 2022: Clinical Infectious Diseases
#39
Sunil Basukala, Shriya Sharma, Ayush Tamang, Ujwal Bhusal
Introduction: Scrub typhus presents with diverse clinical manifestations which range from sub-clinical disease to organ failure and fatal disease. Case presentation: The patient presented with fever followed by acute abdominal pain and later developed septic shock with multi-organ failure. Radiological evaluations were normal, however, on thorough physical examination, an eschar was found in her right inguinal region. Clinical discussion: Aside from classical clinical symptoms, it can also involve various organs, most commonly of respiratory, cardiovascular and hepatic systems...
February 2022: Annals of Medicine and Surgery
#40
Shiho Amano, Ryuichi Ohta, Chiaki Sano
Natural killer T cell intravascular lymphoma is a rare category of lymphoma among older individuals. The presentation of natural killer T cell lymphoma varies, causing diagnostic challenges for clinicians. Thus far, only a few studies have reported this condition in the context of musculoskeletal symptoms. We encountered a case of natural killer T cell intravascular lymphoma in a patient who presented with symptoms of sternoclavicular arthritis and femoral pain. The initial diagnosis was undifferentiated hematologic malignancy because undifferentiated hematologic malignant cells were seen on the bone marrow biopsy...
December 2021: Curēus
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