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acute undifferentiated fever

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https://www.readbyqxmd.com/read/27793106/characteristics-of-acute-febrile-illness-and-determinants-of-illness-recovery-among-adults-presenting-to-singapore-primary-care-clinics
#1
Zaw Myo Tun, Mahesh Moorthy, Martin Linster, Yvonne Cf Su, Richard James Coker, Eng Eong Ooi, Jenny Guek-Hong Low, Gavin J D Smith, Clarence C Tam
BACKGROUND: Undifferentiated acute febrile illness (AFI) is a common presentation among adults in primary care settings in Singapore but large gaps exist in the understanding of the characteristics of these patients. We studied clinical and epidemiological characteristics of AFI patients and factors associated with delayed recovery from AFI. METHODS: We performed a secondary data analysis using data from the Early DENgue infection and outcome (EDEN) study on 2046 adult patients presenting at 5 Singapore polyclinics between December 2007 and February 2013 with a history of fever (≥38 °C) for less than 72 h...
October 28, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27757247/an-outbreak-investigation-of-scrub-typhus-in-western-province-solomon-islands-2014
#2
Michael Marks, Cynthia Joshua, Jenny Longbottom, Katherine Longbottom, Alison Sio, Elliot Puiahi, Greg Jilini, John Stenos, Tenneth Dalipanda, Jennie Musto
OBJECTIVE: To identify the etiology and risk factors of undifferentiated fever in a cluster of patients in Western Province, Solomon Islands, May 2014. METHODS: An outbreak investigation with a case control study was conducted. A case was defined as an inpatient in one hospital in Western Province, Solomon Islands with high fever (> 38.5 °C) and a negative malaria microscopy test admitted between 1 and 31 May 2014. Asymptomatic controls matched with the cases residentially were recruited in a ratio of 1:2...
January 2016: Western Pacific Surveillance and Response Journal: WPSAR
https://www.readbyqxmd.com/read/27716337/clinical-and-paraclinical-profile-and-predictors-of-outcome-in-90-cases-of-scrub-typhus-meghalaya-india
#3
Sunuraj Sivarajan, Siddharudha Shivalli, Debomallya Bhuyan, Michael Mawlong, Rittwick Barman
BACKGROUND: India is an integral component of "tsutsugamushi triangle" which depicts a part of the globe endemic to scrub typhus. Owing to frequent outbreaks witnessed in different parts of the country in the recent past, scrub typhus is described as a re-emerging infectious disease in India. The present study aimed to study the clinical and paraclinical profile, complications and predictors of outcome among 90 cases of scrub typhus diagnosed in a hospital of north-eastern India from Sept 2011 to Aug 2012...
October 5, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27711206/emergence-of-epidemic-dengue-1-virus-in-the-southern-province-of-sri-lanka
#4
Champica K Bodinayake, L Gayani Tillekeratne, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara Arachichi, John J Strouse, October M Sessions, Ruvini Kurukulasooriya, Anna Uehara, Shiqin Howe, Xin Mei Ong, Sharon Tan, Angelia Chow, Praveen Tummalapalli, Aruna D De Silva, Truls Østbye, Christopher W Woods, Duane J Gubler, Megan E Reller
BACKGROUND: Dengue is a frequent cause of acute febrile illness with an expanding global distribution. Since the 1960s, dengue in Sri Lanka has been documented primarily along the heavily urbanized western coast with periodic shifting of serotypes. Outbreaks from 2005-2008 were attributed to a new clade of DENV-3 and more recently to a newly introduced genotype of DENV-1. In 2007, we conducted etiologic surveillance of acute febrile illness in the Southern Province and confirmed dengue in only 6...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27680577/leptospirosis-in-a-british-soldier-after-travel-to-borneo
#5
Daniel S Burns, K A Clay, M S Bailey
Undifferentiated febrile illness in a returning soldier is a common problem encountered by serving medical officers. A 32-year-old soldier presented to Birmingham Heartlands Hospital with fever and acute kidney injury after return from Borneo. Leptospirosis was suspected and empirical antibiotics were started before subsequent confirmation by serology and PCR. Leptospirosis is common in South-East Asia, and troops exercising in jungle areas, and in the UK, are at risk. Advice, including inpatient management when appropriate, is available from the UK Role 4 Military Infectious Diseases and Tropical Medicine Service...
December 2016: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/27580335/detection-and-identification-of-coxsackievirus-b3-from-sera-of-an-indonesian-patient-with-undifferentiated-febrile-illness
#6
Ageng Wiyatno, Ungke Antonjaya, Chairin Nisa Ma'roef, Silvita Fitri Riswari, Hofiya Djauhari, I Made Artika, Corina Monagin, Bradley S Schneider, Khin Saw Myint, Bachti Alisjahbana, Dodi Safari, Herman Kosasih
INTRODUCTION: Coxsackievirus B3 (CVB3) virus has been implicated as the causative agent of various outbreaks of clinical disease, including hand, foot, and mouth diseases, aseptic meningitis, acute myocarditis, and inflammatory cardiomyopathy. METHODOLOGY: Two hundred and nine undiagnosed cryopreserved specimens obtained from factory workers in Bandung, Indonesia, who displayed symptoms of acute febrile illness were gathered. Total RNA was isolated from serum and tested by conventional polymerase chain reaction (PCR) using Enterovirus genus-level primers and confirmed by sequencing...
2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27573633/scrub-typhus-in-northeastern-thailand-eschar-distribution-abnormal-electrocardiographic-findings-and-predictors-of-fatal-outcome
#7
Wilawan Thipmontree, Wiwit Tantibhedhyangkul, Saowaluk Silpasakorn, Ekkarat Wongsawat, Duangdao Waywa, Yupin Suputtamongkol
Scrub typhus is endemic in Thailand. Of the 495 patients with acute undifferentiated fever studied in Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima, Thailand, from June 1, 2011, to December 31, 2012, 146 patients (29.5%) had confirmed scrub typhus. The majority of cases were male, farmers, with the mean (±standard deviation) age of 54.1 ± 15.2 years. A total of 59 patients (40.4%) had eschar lesion. The commonest sites for an eschar in male patients were the perineum, inguinal, and buttock area; whereas in females, it was the head and neck area...
October 5, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27429138/state-of-the-art-of-diagnosis-of-rickettsial-diseases-the-use-of-blood-specimens-for-diagnosis-of-scrub-typhus-spotted-fever-group-rickettsiosis-and-murine-typhus
#8
Daniel H Paris, J Stephen Dumler
PURPOSE OF REVIEW: With improved malaria control, acute undifferentiated febrile illness studies in tropical regions reveal a startling proportion of rickettsial illnesses, especially scrub typhus, murine typhus, and spotted fever group rickettsioses. Laboratory diagnosis of these infections evolved little over the past 40 years, but combinations of technologies like PCR and loop-mediated isothermal amplification, with refined rapid diagnostic tests and/or ELISA, are promising for guidance for early antirickettsial treatment...
October 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27416029/rickettsial-disease-in-the-peruvian-amazon-basin
#9
Claudine Kocher, Amy C Morrison, Mariana Leguia, Steev Loyola, Roger M Castillo, Hugo A Galvez, Helvio Astete, Carmen Flores-Mendoza, Julia S Ampuero, Daniel G Bausch, Eric S Halsey, Manuel Cespedes, Karine Zevallos, Ju Jiang, Allen L Richards
Using a large, passive, clinic-based surveillance program in Iquitos, Peru, we characterized the prevalence of rickettsial infections among undifferentiated febrile cases and obtained evidence of pathogen transmission in potential domestic reservoir contacts and their ectoparasites. Blood specimens from humans and animals were assayed for spotted fever group rickettsiae (SFGR) and typhus group rickettsiae (TGR) by ELISA and/or PCR; ectoparasites were screened by PCR. Logistic regression was used to determine associations between patient history, demographic characteristics of participants and symptoms, clinical findings and outcome of rickettsial infection...
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27389396/a-high-malaria-prevalence-identified-by-pcr-among-patients-with-acute-undifferentiated-fever-in-india
#10
Christel Gill Haanshuus, Sara Chandy, Anand Manoharan, Rosario Vivek, Dilip Mathai, Deepika Xena, Ashita Singh, Nina Langeland, Bjørn Blomberg, George Vasanthan, Usha Sitaram, Jonathan Appasamy, Joel Nesaraj, Anil Henry, Suvarna Patil, Gerardo Alvarez-Uria, Lois Armstrong, Kristine Mørch
BACKGROUND: Approximately one million malaria cases were reported in India in 2015, based on microscopy. This study aims to assess the malaria prevalence among hospitalised fever patients in India identified by PCR, and to evaluate the performance of routine diagnostic methods. METHODS: During June 2011-December 2012, patients admitted with acute undifferentiated fever to seven secondary level community hospitals in Assam (Tezpur), Bihar (Raxaul), Chhattisgarh (Mungeli), Maharashtra (Ratnagiri), Andhra Pradesh (Anantapur) and Tamil Nadu (Oddanchatram and Ambur) were included...
2016: PloS One
https://www.readbyqxmd.com/read/27375618/the-cellular-bases-of-antibody-responses-during-dengue-virus-infection
#11
REVIEW
Juan Carlos Yam-Puc, Leticia Cedillo-Barrón, Elsa Maribel Aguilar-Medina, Rosalío Ramos-Payán, Alejandro Escobar-Gutiérrez, Leopoldo Flores-Romo
Dengue virus (DENV) is one of the most significant human viral pathogens transmitted by mosquitoes and can cause from an asymptomatic disease to mild undifferentiated fever, classical dengue, and severe dengue. Neutralizing memory antibody (Ab) responses are one of the most important mechanisms that counteract reinfections and are therefore the main aim of vaccination. However, it has also been proposed that in dengue, some of these class-switched (IgG) memory Abs might worsen the disease. Although these memory Abs derive from B cells by T-cell-dependent processes, we know rather little about the (acute, chronic, or memory) B cell responses and the complex cellular mechanisms generating these Abs during DENV infections...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27209095/diagnosis-and-management-of-undifferentiated-fever-in-children
#12
Sarah S Long
The incidence and likely causes of fever of unknown origin (FUO) have changed over the last few decades, largely because enhanced capabilities of laboratory testing and imaging have helped confirm earlier diagnoses. History and examination are still of paramount importance for cryptogenic infections. Adolescents who have persisting nonspecific complaints of fatigue sometimes are referred to Pediatric Infectious Diseases consultants for FUO because the problem began with an acute febrile illness or measured temperatures are misidentified as "fevers"...
July 5, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27198211/quantitative-and-volume-conductivity-and-scatter-changes-in-leucocytes-of-patients-with-acute-undifferentiated-febrile-illness-a-pilot-study
#13
Varun Kalra, Sohaib Ahmad, Vikas Shrivastava, Garima Mittal
BACKGROUND: A single diagnostic test for acute undifferentiated febrile illnesses (AUFI) is elusive. This pilot study was undertaken on the premise that leucocytes, being the main cells of defence, undergo quantitative, structural and functional changes in AUFI. We evaluated the potential of volume, conductivity and scatter (VCS) parameters of leucocytes, generated with the haemogram report by the Coulter auto-analyzer, in differentiating the common etiologies of AUFI. METHODS: The haematological and VCS data obtained from 800 controls and 200 cases of AUFI (50 cases each of acute malaria, dengue, scrub typhus and enteric fever) were retrieved for analysis...
May 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27180244/deep-sequencing-approach-for-investigating-infectious-agents-causing-fever
#14
T N Susilawati, A R Jex, C Cantacessi, M Pearson, S Navarro, A Susianto, A C Loukas, W J H McBride
Acute undifferentiated fever (AUF) poses a diagnostic challenge due to the variety of possible aetiologies. While the majority of AUFs resolve spontaneously, some cases become prolonged and cause significant morbidity and mortality, necessitating improved diagnostic methods. This study evaluated the utility of deep sequencing in fever investigation. DNA and RNA were isolated from plasma/sera of AUF cases being investigated at Cairns Hospital in northern Australia, including eight control samples from patients with a confirmed diagnosis...
July 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27054362/the-relationship-between-poverty-and-healthcare-seeking-among-patients-hospitalized-with-acute-febrile-illnesses-in-chittagong-bangladesh
#15
M Trent Herdman, Richard James Maude, Md Safiqul Chowdhury, Hugh W F Kingston, Atthanee Jeeyapant, Rasheda Samad, Rezaul Karim, Arjen M Dondorp, Md Amir Hossain
Delays in seeking appropriate healthcare can increase the case fatality of acute febrile illnesses, and circuitous routes of care-seeking can have a catastrophic financial impact upon patients in low-income settings. To investigate the relationship between poverty and pre-hospital delays for patients with acute febrile illnesses, we recruited a cross-sectional, convenience sample of 527 acutely ill adults and children aged over 6 months, with a documented fever ≥38.0 °C and symptoms of up to 14 days' duration, presenting to a tertiary referral hospital in Chittagong, Bangladesh, over the course of one year from September 2011 to September 2012...
2016: PloS One
https://www.readbyqxmd.com/read/27042465/utility-of-serological-tests-in-the-era-of-molecular-testing-for-diagnosis-of-human-brucellosis-in-endemic-area-with-limited-resources
#16
Shashank Purwar, Sharada C Metgud, Manohar B Mutnal, Mahantesh B Nagamoti, Chidanand S Patil
BACKGROUND: The culture has always been the gold standard test for diagnosis of human brucellosis but the conventional Brucella diagnostic tests viz. serology and culture are often beset with poor specificity & sensitivity respectively. The culture positivity rates for Brucella vary from 92% for bone marrow to 10% for non-blood samples and also dependent on the type of sample. The primary immune-determinant for Brucella species is the cell wall surface lipopolysaccharide, which is antigenically similar to other gram-negative rods...
February 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27008880/optimal-cutoff-and-accuracy-of-an-igm-enzyme-linked-immunosorbent-assay-for-diagnosis-of-acute-scrub-typhus-in-northern-thailand-an-alternative-reference-method-to-the-igm-immunofluorescence-assay
#17
Stuart D Blacksell, Cherry Lim, Ampai Tanganuchitcharnchai, Suthatip Jintaworn, Pacharee Kantipong, Allen L Richards, Daniel H Paris, Direk Limmathurotsakul, Nicholas P J Day
The enzyme-linked immunosorbent assay (ELISA) has been proposed as an alternative serologic diagnostic test to the indirect immunofluorescence assay (IFA) for scrub typhus. Here, we systematically determine the optimal sample dilution and cutoff optical density (OD) and estimate the accuracy of IgM ELISA using Bayesian latent class models (LCMs). Data from 135 patients with undifferentiated fever were reevaluated using Bayesian LCMs. Every patient was evaluated for the presence of an eschar and tested with a blood culture for Orientia tsutsugamushi, three different PCR assays, and an IgM IFA...
June 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/26968374/clinical-evaluation-of-dengue-and-identification-of-risk-factors-for-severe-disease-protocol-for-a-multicentre-study-in-8-countries
#18
MULTICENTER STUDY
Thomas Jaenisch, Dong Thi Hoai Tam, Nguyen Tan Thanh Kieu, Tran Van Ngoc, Nguyen Tran Nam, Nguyen Van Kinh, Sophie Yacoub, Ngoun Chanpheaktra, Varun Kumar, Lucy Lum Chai See, Jameela Sathar, Ernesto Pleités Sandoval, Gabriela Maria Marón Alfaro, Ida Safitri Laksono, Yodi Mahendradhata, Malabika Sarker, Firoz Ahmed, Andrea Caprara, Bruno Souza Benevides, Ernesto T A Marques, Tereza Magalhaes, Patricia Brasil, Marco Netto, Adriana Tami, Sarah E Bethencourt, Maria Guzman, Cameron Simmons, Nguyen Thanh Ha Quyen, Laura Merson, Nguyen Thi Phuong Dung, Dorothea Beck, Marius Wirths, Marcel Wolbers, Phung Khanh Lam, Kerstin Rosenberger, Bridget Wills
BACKGROUND: The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ impairment, and hypovolaemic shock due to a systemic vascular leak syndrome. Clinical diagnosis of dengue and identification of which patients are likely to develop severe disease remain challenging...
March 11, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26927901/laboratory-enhanced-dengue-sentinel-surveillance-in-colombo-district-sri-lanka-2012-2014
#19
Hasitha Tissera, Ananda Amarasinghe, Sunethra Gunasena, Aruna Dharshan DeSilva, Leong Wei Yee, October Sessions, Chanaka Muthukuda, Paba Palihawadana, Wolfgang Lohr, Peter Byass, Duane J Gubler, Annelies Wilder-Smith
INTRODUCTION: Dengue has emerged as a significant public health problem in Sri Lanka. Historically surveillance was passive, with mandatory dengue notifications based on clinical diagnosis with only limited laboratory confirmation. To obtain more accurate data on the disease burden of dengue, we set up a laboratory-based enhanced sentinel surveillance system in Colombo District. Here we describe the study design and report our findings of enhanced surveillance in the years 2012-2014. METHODS: Three outpatient clinics and three government hospitals in Colombo District that covered most of the Colombo metropolitan area were selected for the sentinel surveillance system...
February 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26923064/antibiotics-for-preventing-suppurative-complications-from-undifferentiated-acute-respiratory-infections-in-children-under-five-years-of-age
#20
REVIEW
Márcia G Alves Galvão, Marilene Augusta Rocha Crispino Santos, Antonio J L Alves da Cunha
BACKGROUND: Undifferentiated acute respiratory infections (ARIs) are a large and heterogeneous group of infections not clearly restricted to one specific part of the upper respiratory tract, which last for up to seven days. They are more common in pre-school children in low-income countries and are responsible for 75% of the total amount of prescribed antibiotics in high-income countries. One possible rationale for prescribing antibiotics is the wish to prevent bacterial complications...
2016: Cochrane Database of Systematic Reviews
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