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acute undifferentiated fever

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https://www.readbyqxmd.com/read/29075423/myeloid-sarcoma-of-the-oral-cavity-a-case-report-and-review-of-89-cases-from-the-literature
#1
Bruno-Augusto-Benevenuto de Andrade, Renan-de Barros Farneze, Michelle Agostini, Ellen-Brilhante Cortezzi, Aline-Corrêa Abrahão, Marcia-Grillo Cabral, Alicia Rumayor, Mário-José Romañach
Myeloid sarcoma is a tumor mass of immature myeloid or granulocytic cells that affects extramedullary anatomic sites, including uncommonly the oral cavity. A 24-year-old female was referred for evaluation of a fast growing painful gingival swelling lasting 2 weeks, associated with fever, fatigue, and cervical lymphadenopathy. Intraoral examination showed a bluish swelling on the right posterior lower gingiva exhibiting necrotic surface. Incisional biopsy of the gingival lesion displayed diffuse infiltration of undifferentiated tumor cells with granulocytic appearance, strongly immunopositive for CD99, myeloperoxidase and Ki-67 (60%), and negative for CD20, CD3, CD34 and TdT...
September 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28978319/acute-undifferentiated-fever-in-india-a-multicentre-study-of-aetiology-and-diagnostic-accuracy
#2
Kristine Mørch, Anand Manoharan, Sara Chandy, Novin Chacko, Gerardo Alvarez-Uria, Suvarna Patil, Anil Henry, Joel Nesaraj, Cijoy Kuriakose, Ashita Singh, Siby Kurian, Christel Gill Haanshuus, Nina Langeland, Bjørn Blomberg, George Vasanthan Antony, Dilip Mathai
BACKGROUND: The objectives of this study were to determine the proportion of malaria, bacteraemia, scrub typhus, leptospirosis, chikungunya and dengue among hospitalized patients with acute undifferentiated fever in India, and to describe the performance of standard diagnostic methods. METHODS: During April 2011-November 2012, 1564 patients aged ≥5 years with febrile illness for 2-14 days were consecutively included in an observational study at seven community hospitals in six states in India...
October 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28968807/chymase-is-a-predictive-biomarker-of-dengue-hemorrhagic-fever-in-pediatric-and-adult-patients
#3
Hasitha Tissera, Abhay P S Rathore, Wei Yee Leong, Brian L Pike, Tyler E Warkentien, Farouk S Farouk, Ayesa Syenina, Eng Eong Ooi, Duane J Gubler, Annelies Wilder-Smith, Ashley L St John
Background: Most dengue patients experience mild disease, dengue fever (DF), while few develop life-threatening severe disease, or dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). No laboratory tests predict DHF/DSS. We evaluated whether serum chymase can predict DHF/DSS in adult and pediatric patients and the influence of pre-existing conditions (PECs) on chymase levels. Methods: Serum chymase levels were measured in patients presenting with undifferentiated fever to hospitals in Colombo District, Sri Lanka...
August 25, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28835429/a-rare-case-of-pulmonary-toxoplasmosis-in-a-patient-with-undifferentiated-inflammatory-arthritis-on-chronic-methotrexate-and-corticosteroid-therapy
#4
Abdullateef Abdulkareem, Ryan Steven D'Souza, Nitin Patel, Anthony A Donato
Pulmonary toxoplasmosis is a serious pulmonary condition caused by the protozoan Toxoplasma gondii It typically affects immunocompromised patients presenting acutely with cough, fever, myalgias, arthralgias and lymphadenopathy, and chronically with persistent cough and dyspnoea. Because of its protean features, it can mimic many more common lung conditions in the immunocompromised patient, including atypical pneumonia, Pneumocystis pneumonia and interstitial lung disease. In this article, we present the case of a 55-year-old woman who presented to our hospital with persistent dyspnoea and cough, initially suspected to have an arthritis-related interstitial lung disease...
August 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28799301/rickettsial-infections-in-goa-not-just-scrub-typhus
#5
Kedareshwar Narvencar, Gurleen Kaur, Savio Rodrigues
BACKGROUND AND OBJECTIVE: Rickettsial infections are an important cause of undifferentiated febrile illness in tropics. While scrub typhus was reported from Goa, other rickettsial infections have not been reported earlier. The present study was planned to identify pattern of rickettsial infections in Goa. MATERIALS AND METHODS: All patients presenting with undiagnosed acute febrile illness were recruited over a two-year period. Other causes of febrile illness were ruled out by appropriate tests...
August 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28722568/epidemiology-of-spotted-fever-group-rickettsioses-and-acute-undifferentiated-febrile-illness-in-villeta-colombia
#6
Álvaro A Faccini-Martínez, Alejandro Ramírez-Hernández, Christian Barreto, Elkin Forero-Becerra, Diego Millán, Elkin Valbuena, Andrea C Sánchez-Alfonso, Wilson O Imbacuán-Pantoja, Jesús A Cortés-Vecino, Luis J Polo-Terán, Néstor Yaya-Lancheros, Jorge Jácome, Ana M Palomar, Sonia Santibáñez, Aránzazu Portillo, José A Oteo, Marylin Hidalgo
Etiology of acute undifferentiated febrile syndrome (AUFS) is often unknown, leading to inaccurate diagnosis and treatment. Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other Rickettsia species different from Rickettsia rickettsii. Besides, few studies have approached other AUFS etiologies in the region. We investigated the role of dengue, leptospirosis, rickettsioses, human anaplasmosis, and Q fever as possible causes of AUFS in patients from Villeta...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28399929/xanthogranulomatous-pyelonephritis-presenting-as-acute-pleuritic-chest-pain-a-case-report
#7
Justin Chow, Rameez Kabani, Kirstie Lithgow, Magdalena A Sarna
BACKGROUND: Xanthogranulomatous pyelonephritis is a rare and serious manifestation of chronic kidney inflammation that can be life-threatening if not recognized and treated appropriately, often with antibiotics and surgery. Affected patients are most commonly females in their fifth or sixth decade of life with a background of obstructive uropathy, nephrolithiasis, or recurrent urinary tract infections who present with vague nonspecific symptoms. CASE PRESENTATION: A 43-year-old woman of Russian ethnicity with a history of nephrolithiasis presented to our emergency department with new left-sided pleuritic chest pain amid a 6-week history of constitutional symptoms including fevers, night sweats, and 7 kg of weight loss...
April 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28393899/increased-serum-hyaluronic-acid-and-heparan-sulfate-in-dengue-fever-association-with-plasma-leakage-and-disease-severity
#8
Tommy Hing-Cheung Tang, Sylvie Alonso, Lisa Fong-Poh Ng, Tun-Linn Thein, Vincent Jun-Xiong Pang, Yee-Sin Leo, David Chien-Boon Lye, Tsin-Wen Yeo
Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever screened for dengue by RT-PCR or NS1 antigen testing was performed. Patients were assessed daily while symptomatic and at convalescence. Serum hyaluronic acid (HA), heparan sulfate (HS) and selected cytokines (TNF-α, IL-6, IL-10) were measured on enrollment and convalescence...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28250620/clinical-score-to-differentiate-scrub-typhus-and-dengue-a-tool-to-differentiate-scrub-typhus-and-dengue
#9
Shubhanker Mitra, Ira Gautam, Mohan Jambugulam, Kundavaram Paul Prabhakar Abhilash, Vishalakshi Jayaseeelan
BACKGROUND: Dengue and scrub typhus share similar clinical and epidemiological features, and are difficult to differentiate at initial presentation. Many places are endemic to both these infections where they comprise the majority of acute undifferentiated febrile illnesses. MATERIALS AND METHODS: We aimed to develop a score that can differentiate scrub typhus from dengue. In this cross-sectional study, 188 cases of scrub typhus and 201 cases of dengue infection who presented to the emergency department or medicine outpatient clinic from September 2012 to April 2013 were included...
January 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28250618/utility-of-loop-mediated-isothermal-amplification-assay-polymerase-chain-reaction-and-elisa-for-diagnosis-of-leptospirosis-in-south-indian-patients
#10
Mallika Sengupta, Abhilash Kundavaram Paul Prabhakar, Sowmya Satyendra, David Thambu, Ooriapadickal Cherian Abraham, Veeraraghavan Balaji, Hua-Wei Chen, Chien-Chung Chao, Wei-Mei Ching, John Antony Jude Prakash
BACKGROUND: Leptospirosis is a zoonotic disease which requires laboratory diagnosis for confirmation. MATERIALS AND METHODS: In this study serum samples from adults with acute undifferentiated fever (duration ≤15 days) were tested for IgM antibodies to Leptospira by ELISA, PCR for rrs gene and loop-mediated isothermal amplification (LAMP) assay for LipL32 and LipL41. RESULTS: Among the 150 sera tested, three were positive by PCR, LAMP and IgM ELISA/modified Faines' criteria, two by only PCR; seven only by LAMP assay and forty fulfilled modified Faine's criteria (illness clinically compatible and IgM ELISA positive for leptospirosis)...
January 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28250617/state-of-the-globe-impracticality-of-clinical-scores-in-acute-undifferentiated-fever-a-global-challenge
#11
EDITORIAL
Vivek Chauhan, Suman Thakur
No abstract text is available yet for this article.
January 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28195095/molecular-detection-of-orientia-tsutsugamushi-from-suspected-scrub-typhus-cases
#12
COMPARATIVE STUDY
Seethalakshmi Srinivasan, Thangam Menon
CONTEXT: Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi. The disease is under-diagnosed in India, because of low index of suspicion and also due to its nonspecific presentation, and lack of confirmatory diagnostic tests. AIMS: This study was undertaken to diagnose scrub typhus in patients with undifferentiated fevers by serology and molecular methods. MATERIALS AND METHODS: A total of 68 blood samples were collected from patients clinically suspected to have scrub typhus...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28036394/first-identification-and-description-of-rickettsioses-and-q-fever-as-causes-of-acute-febrile-illness-in-nicaragua
#13
Megan E Reller, Ijeuru Chikeka, Jeremy J Miles, J Stephen Dumler, Christopher W Woods, Orlando Mayorga, Armando J Matute
BACKGROUND: Rickettsial infections and Q fever present similarly to other acute febrile illnesses, but are infrequently diagnosed because of limited diagnostic tools. Despite sporadic reports, rickettsial infections and Q fever have not been prospectively studied in Central America. METHODOLOGY/PRINCIPAL FINDINGS: We enrolled consecutive patients presenting with undifferentiated fever in western Nicaragua and collected epidemiologic and clinical data and acute and convalescent sera...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27942194/acute-undifferentiated-febrile-illness-in-patients-presenting-to-a-tertiary-care-hospital-in-south-india-clinical-spectrum-and-outcome
#14
Kundavaram Paul Prabhakar Abhilash, Jonathan Arul Jeevan, Shubhanker Mitra, Nirvin Paul, Thimiri Palani Murugan, Ajay Rangaraj, Sandeep David, Samuel George Hansdak, John Antony Jude Prakash, Asha Mary Abraham, Prakash Ramasami, Sowmya Sathyendra, Thambu David Sudarsanam, George M Varghese
BACKGROUND: Acute undifferentiated febrile illness (AUFI) may have similar clinical presentation, and the etiology is varied and region specific. MATERIALS AND METHODS: This prospective observational study was conducted in a tertiary hospital in South India. All adult patients presenting with AUFI of 3-14 days duration were evaluated for etiology, and the differences in presentation and outcome were analyzed. RESULTS: The study cohort included 1258 patients...
October 2016: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/27793106/characteristics-of-acute-febrile-illness-and-determinants-of-illness-recovery-among-adults-presenting-to-singapore-primary-care-clinics
#15
Zaw Myo Tun, Mahesh Moorthy, Martin Linster, Yvonne Cf Su, Richard James Coker, Eng Eong Ooi, Jenny Guek-Hong Low, Gavin J D Smith, Clarence C Tam
BACKGROUND: Undifferentiated acute febrile illness (AFI) is a common presentation among adults in primary care settings in Singapore but large gaps exist in the understanding of the characteristics of these patients. We studied clinical and epidemiological characteristics of AFI patients and factors associated with delayed recovery from AFI. METHODS: We performed a secondary data analysis using data from the Early DENgue infection and outcome (EDEN) study on 2046 adult patients presenting at 5 Singapore polyclinics between December 2007 and February 2013 with a history of fever (≥38 °C) for less than 72 h...
October 28, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27757247/an-outbreak-investigation-of-scrub-typhus-in-western-province-solomon-islands-2014
#16
Michael Marks, Cynthia Joshua, Jenny Longbottom, Katherine Longbottom, Alison Sio, Elliot Puiahi, Greg Jilini, John Stenos, Tenneth Dalipanda, Jennie Musto
OBJECTIVE: To identify the etiology and risk factors of undifferentiated fever in a cluster of patients in Western Province, Solomon Islands, May 2014. METHODS: An outbreak investigation with a case control study was conducted. A case was defined as an inpatient in one hospital in Western Province, Solomon Islands with high fever (> 38.5 °C) and a negative malaria microscopy test admitted between 1 and 31 May 2014. Asymptomatic controls matched with the cases residentially were recruited in a ratio of 1:2...
January 2016: Western Pacific Surveillance and Response Journal: WPSAR
https://www.readbyqxmd.com/read/27716337/clinical-and-paraclinical-profile-and-predictors-of-outcome-in-90-cases-of-scrub-typhus-meghalaya-india
#17
Sunuraj Sivarajan, Siddharudha Shivalli, Debomallya Bhuyan, Michael Mawlong, Rittwick Barman
BACKGROUND: India is an integral component of "tsutsugamushi triangle" which depicts a part of the globe endemic to scrub typhus. Owing to frequent outbreaks witnessed in different parts of the country in the recent past, scrub typhus is described as a re-emerging infectious disease in India. The present study aimed to study the clinical and paraclinical profile, complications and predictors of outcome among 90 cases of scrub typhus diagnosed in a hospital of north-eastern India from Sept 2011 to Aug 2012...
October 5, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27711206/emergence-of-epidemic-dengue-1-virus-in-the-southern-province-of-sri-lanka
#18
Champica K Bodinayake, L Gayani Tillekeratne, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara Arachichi, John J Strouse, October M Sessions, Ruvini Kurukulasooriya, Anna Uehara, Shiqin Howe, Xin Mei Ong, Sharon Tan, Angelia Chow, Praveen Tummalapalli, Aruna D De Silva, Truls Østbye, Christopher W Woods, Duane J Gubler, Megan E Reller
BACKGROUND: Dengue is a frequent cause of acute febrile illness with an expanding global distribution. Since the 1960s, dengue in Sri Lanka has been documented primarily along the heavily urbanized western coast with periodic shifting of serotypes. Outbreaks from 2005-2008 were attributed to a new clade of DENV-3 and more recently to a newly introduced genotype of DENV-1. In 2007, we conducted etiologic surveillance of acute febrile illness in the Southern Province and confirmed dengue in only 6...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27680577/leptospirosis-in-a-british-soldier-after-travel-to-borneo
#19
Daniel S Burns, K A Clay, M S Bailey
Undifferentiated febrile illness in a returning soldier is a common problem encountered by serving medical officers. A 32-year-old soldier presented to Birmingham Heartlands Hospital with fever and acute kidney injury after return from Borneo. Leptospirosis was suspected and empirical antibiotics were started before subsequent confirmation by serology and PCR. Leptospirosis is common in South-East Asia, and troops exercising in jungle areas, and in the UK, are at risk. Advice, including inpatient management when appropriate, is available from the UK Role 4 Military Infectious Diseases and Tropical Medicine Service...
December 2016: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/27580335/detection-and-identification-of-coxsackievirus-b3-from-sera-of-an-indonesian-patient-with-undifferentiated-febrile-illness
#20
Ageng Wiyatno, Ungke Antonjaya, Chairin Nisa Ma'roef, Silvita Fitri Riswari, Hofiya Djauhari, I Made Artika, Corina Monagin, Bradley S Schneider, Khin Saw Myint, Bachti Alisjahbana, Dodi Safari, Herman Kosasih
INTRODUCTION: Coxsackievirus B3 (CVB3) virus has been implicated as the causative agent of various outbreaks of clinical disease, including hand, foot, and mouth diseases, aseptic meningitis, acute myocarditis, and inflammatory cardiomyopathy. METHODOLOGY: Two hundred and nine undiagnosed cryopreserved specimens obtained from factory workers in Bandung, Indonesia, who displayed symptoms of acute febrile illness were gathered. Total RNA was isolated from serum and tested by conventional polymerase chain reaction (PCR) using Enterovirus genus-level primers and confirmed by sequencing...
August 31, 2016: Journal of Infection in Developing Countries
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