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nanoparticle vaccine

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https://www.readbyqxmd.com/read/28943194/intradermal-vaccination-with-hollow-microneedles-a-comparative-study-of-various-protein-antigen-and-adjuvant-encapsulated-nanoparticles
#1
Guangsheng Du, Rania M Hathout, Maha Nasr, M Reza Nejadnik, Jing Tu, Roman I Koning, Abraham J Koster, Bram Slütter, Alexander Kros, Wim Jiskoot, Joke A Bouwstra, Juha Mönkäre
In this study, we investigated the potential of intradermal delivery of nanoparticulate vaccines to modulate the immune response of protein antigen using hollow microneedles. Four types of nanoparticles covering a broad range of physiochemical parameters, namely poly (lactic-co-glycolic) (PLGA) nanoparticles, liposomes, mesoporous silica nanoparticles (MSNs) and gelatin nanoparticles (GNPs) were compared. The developed nanoparticles were loaded with a model antigen (ovalbumin (OVA)) with and without an adjuvant (poly(I:C)), followed by the characterization of size, zeta potential, morphology, and loading and release of antigen and adjuvant...
September 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28937293/enhancing-tumor-specific-immune-responses-by-transcutaneous-vaccination
#2
Hanadi Saliba, Béatrice Heurtault, Hasnaa Bouharoun-Tayoun, Vincent Flacher, Benoît Frisch, Sylvie Fournel, Soulaima Chamat
Introduction Our understanding of the involvement of the immune system in cancer control has increased over recent years. However, the development of cancer vaccines intended to reverse tumor-induced immune tolerance remains slow as most current vaccine candidates exhibit limited clinical efficacy. The skin is particularly rich with multiple subsets of dendritic cells (DCs) that are involved to varying degrees in the induction of robust immune responses. Transcutaneous administration of cancer vaccines may therefore harness the immune potential of these DCs, however, this approach is hampered by the impermeability of the stratum corneum...
September 22, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28936523/mesoporous-zno-nanocapsules-for-the-induction-of-enhanced-antigen-specific-immunological-responses
#3
Sumbul Afroz, Himadri Medhi, Somedutta Maity, Gillipsie Minhas, Srikanth Battu, Jeevan Giddaluru, Koushi Kumar, Pradip Paik, Nooruddin Khan
The application of nanotechnology in vaccinology has fuelled rapid advancement towards the design and development of nanovaccines. Nanoparticles have been found to enhance vaccine efficacy through the spatiotemporal orchestration of antigen delivery to secondary lymphoid organs and antigen-presentation by Antigen Presenting Cells (APCs) synchronized with stimulation of innate and adaptive immune responses. Metal based nanoparticles (MNPs) have been extensively engineered for the generation of nanovaccines owing to their intrinsic adjuvant-like properties and immunomodulatory functions...
September 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28936479/surface-coating-of-nanoparticles-reduces-background-inflammatory-activity-while-increasing-particle-uptake-and-delivery
#4
Brittany A Moser, Rachel C Steinhardt, Aaron P Esser-Kahn
In the study of host-pathogen interactions, vaccines and drug delivery, particulate delivery system are widely used to mimic pathogen size, pattern recognition receptor agonist presentation, and target cells or organs. However, some of the polymeric systems used in particulate delivery have inherent inflammatory properties that are variable and nonspecific. These properties enhance their adjuvant activity, but confound the analysis of signaling mechanisms. Here, we present a method for particle coating with minimal background immune activation via passivation of the surface with silica-silane...
February 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28933657/a-novel-immunization-approach-for-dengue-infection-based-on-conserved-t-cell-epitopes-formulated-in-calcium-phosphate-nanoparticles
#5
Xiaofang Huang, Aykan Karabudak, Joseph D Comber, Mohan Philip, Tulin Morcol, Ramila Philip
Dengue virus (DV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Most DV vaccine approaches are focused on generating antibody mediated responses; one such DV vaccine is approved for use in humans but its efficacy is limited. While it is clear that T cell responses play important role in DV infection and subsequent disease manifestations, fewer studies are aimed at developing vaccines that induce robust T cells responses. Potent T cell based vaccines require two critical components: the identification of specific T cell stimulating MHC associated peptides, and an optimized vaccine delivery vehicle capable of simultaneously delivering the antigens and any required adjuvants...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933284/enzyme-instructed-self-assembly-in-biological-milieu-for-theranostics-purpose
#6
Zhentao Huang, Qingxin Yao, Simin Wei, Jiali Chen, Yuan Gao
Precision medicine is in an urgent need for public healthcare. Among the past several decades, the flourishing development in nanotechnology significantly advances the realization of precision nanomedicine. Comparing to well-documented nanoparticle-based strategy, in this review we focus on the strategy using enzyme instructed self-assembly (EISA) in biological milieu for theranostics purpose. In principle, the design of small molecules for EISA requires two aspects: (1) the substrate of enzyme of interest; (2) self-assembly potency after enzymatic conversion...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28932640/co-delivery-of-the-nkt-agonist-%C3%AE-galactosylceramide-and-tumor-antigens-to-cross-priming-dendritic-cells-breaks-tolerance-to-self-antigens-and-promotes-antitumor-responses
#7
Reem Ghinnagow, Julie De Meester, Luis Javier Cruz, Caroline Aspord, Stéphanie Corgnac, Elodie Macho-Fernandez, Daphnée Soulard, Josette Fontaine, Laurence Chaperot, Julie Charles, Fabrice Soncin, Fathia Mami-Chouaib, Joel Plumas, Christelle Faveeuw, François Trottein
Vaccines designed to abrogate the tolerance of tumor self-antigens and amplify cytotoxic CD8(+) T cells (CTLs) have promise for the treatment of cancer. Type I natural killer (NKT) cells have attracted considerable interest in the cancer therapy field. In the current study, we have exploited the unique ability of NKT cells to serve as T-helper cells to license dendritic cells (DCs) for cross priming with the aim to generate efficient CTL antitumor responses. To this end, we designed a nanoparticle-based vaccine to target cross-priming DCs via the Clec9a endocytic pathway...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28921444/polyester-based-nanoparticles-for-delivery-of-therapeutic-proteins
#8
Pedro Fonte, Flávia Sousa, Bruno Sarmento
Therapeutic proteins are widely used to treat severe conditions, such as oncologic and metabolic diseases, and also for vaccination. They are recognized for its high biopotency, but their hydrophilicity and high molecular weight make its transport through membranes difficult to achieve. They may also suffer in vivo structural instability caused by a proteolytic cleavage, turning them biological inactive. Polyester-based nanoparticles are useful tools to overcome such problems, and deliver therapeutic proteins in a controlled and localized manner, decreasing the number of administrations needed and enhancing the therapeutic outcome...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917841/graphene-vp40-interactions-and-potential-disruption-of-the-ebola-virus-matrix-filaments
#9
Jeevan B Gc, Rudramani Pokhrel, Nisha Bhattarai, Kristen A Johnson, Bernard S Gerstman, Robert V Stahelin, Prem P Chapagain
Ebola virus infections cause hemorrhagic fever that often results in very high fatality rates. In addition to exploring vaccines, development of drugs is also essential for treating the disease and preventing the spread of the infection. The Ebola virus matrix protein VP40 exists in various conformational and oligomeric forms and is a potential pharmacological target for disrupting the virus life-cycle. Here we explored graphene-VP40 interactions using molecular dynamics simulations and graphene pelleting assays...
September 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28917531/hollow-microneedle-mediated-intradermal-delivery-of-model-vaccine-antigen-loaded-plga-nanoparticles-elicits-protective-t-cell-mediated-immunity-to-an-intracellular-bacterium
#10
Anne Marit de Groot, Guangsheng Du, Juha Mönkäre, Anouk C M Platteel, Femke Broere, Joke A Bouwstra, Alice J A M Sijts
The skin is an attractive organ for immunization due to the presence of a large number of epidermal and dermal antigen-presenting cells. Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. In this study, ovalbumin (OVA)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles with and without TLR3 agonist poly(I:C) were prepared and administered intradermally by hollow microneedles. The capacity of the PLGA nanoparticles to induce a cytotoxic T cell response, contributing to protection against intracellular pathogens, was examined...
September 14, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28914200/development-of-peptide-vaccines-in-dengue
#11
Kavita Reginald, Yanqi Chan, Magdalena Plebanski, Chit Laa Poh
Dengue is one of the most important arboviral infection worldwide, infecting up to 390 million people and causing 25,000 deaths annually. Although a licensed dengue vaccine is available, it is not efficacious against dengue serotypes that infect people living in South East Asia, where dengue is an endemic disease. Hence, there is an urgent need to develop an efficient dengue vaccine for this region. Data from different clinical trials indicate that a successful dengue vaccine must elicit both neutralizing antibodies and cell mediated immunity...
September 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28903988/the-use-of-reverse-vaccinology-in-the-design-and-construction-of-nano-glycoconjugate-vaccines-against-burkholderia-pseudomallei
#12
Laura A Muruato, Daniel Tapia, Christopher L Hatcher, Mridul Kalita, Paul J Brett, Anthony E Gregory, James E Samuel, Richard W Titball, Alfredo G Torres
Burkholderia pseudomallei (Bpm) is a Gram negative, facultative intracellular pathogen that causes the disease melioidosis in humans and other mammals. Respiratory infection with B. pseudomallei leads to a fulminant and often fatal disease. It has previously been shown that glycoconjugate vaccines can provide significant protection against lethal challenge; however, the limited number of known Burkholderia antigens has slowed progress towards vaccine development. The objective of this study was to identify novel antigens and evaluate their protective capacity when incorporated into a nano-glycoconjugate vaccine platform...
September 13, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28903312/gnp-gapdh1-22-nanovaccines-prevent-neonatal-listeriosis-by-blocking-microglial-apoptosis-and-bacterial-dissemination
#13
Ricardo Calderon-Gonzalez, Elisabet Frande-Cabanes, Hector Teran-Navarro, José María Marimon, Javier Freire, David Salcines-Cuevas, M Carmen Fariñas, Claudia Onzalez-Rico, Marco Marradi, Isabel Garcia, Mirian Alkorta-Gurrutxaga, Aida San Nicolas-Gomez, Ana Castañeda-Sampedro, Sonsoles Yañez-Diaz, Soledad Penades, Carmen Punzon, Javier Gomez-Roman, Fernando Rivera, Manuel Fresno, Carmen Alvarez-Dominguez
Clinical cases of neonatal listeriosis are associated with brain disease and fetal loss due to complications in early or late pregnancy, which suggests that microglial function is altered. This is believed to be the first study to link microglial apoptosis with neonatal listeriosis and listeriosis-associated brain disease, and to propose a new nanovaccine formulation that reverses all effects of listeriosis and confers Listeria monocytogenes (LM)-specific immunity. We examined clinical cases of neonatal listeriosis in 2013-2015 and defined two useful prognostic immune biomarkers to design listeriosis vaccines: high anti-GAPDH1-22 titres and tumor necrosis factor (TNF)/interleukin (IL)-6 ratios...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902491/biodegradable-viral-nanoparticle-polymer-implants-prepared-via-melt-processing
#14
Parker W Lee, Sourabh Shukla, Jaqueline D Wallat, Chaitanya Danda, Nicole F Steinmetz, Joao Maia, Jonathan K Pokorski
Viral nanoparticles have been utilized as a platform for vaccine development and are a versatile system for the display of antigenic epitopes for a variety of disease states. However, the induction of a clinically relevant immune response often requires multiple injections over an extended period of time, limiting patient compliance. Polymeric systems to deliver proteinaceous materials have been extensively researched to provide sustained release, which would limit administration to a single dose. Melt-processing is an emerging manufacturing method that has been utilized to create polymeric materials laden with proteins as an alternative to typical solvent-based production methods...
September 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28901254/therapeutics-and-immunoprophylaxis-against-noroviruses-and-rotaviruses
#15
Souvik Ghosh, Yashpal Singh Malik, Nobumichi Kobayashi
Noroviruses and rotaviruses are important viral etiologies of severe gastroenteritis. Noroviruses are the primary cause of non-bacterial diarrheal outbreaks in humans, whilst rotaviruses are a major cause of childhood diarrhea. Although both enteric pathogens substantially impact human health and economies, there are no approved drugs against noroviruses and rotaviruses, so far. On the other hand, whilst the currently licensed rotavirus vaccines have been successfully implemented in over 100 countries, the most advanced norovirus vaccine has recently completed phase-I and II trials...
September 12, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28884013/reconceptualizing-cancer-immunotherapy-based-on-plant-production-systems
#16
REVIEW
Kathleen Hefferon
Plants can be used as inexpensive and facile production platforms for vaccines and other biopharmaceuticals. More recently, plant-based biologics have expanded to include cancer immunotherapy agents. The following review describes the current state of the art for plant-derived strategies to prevent or reduce cancers. The review discusses avenues taken to prevent infection by oncogenic viruses, solid tumors and lymphomas. Strategies including cancer vaccines, monoclonal antibodies and virus nanoparticles are described, and examples are provided...
August 2017: Future Science OA
https://www.readbyqxmd.com/read/28883727/vaccination-with-poly-d-l-lactide-co-glycolide-nanoparticles-loaded-with-soluble-leishmania-antigens-and-modified-with-a-tnf%C3%AE-mimicking-peptide-or-monophosphoryl-lipid-a-confers-protection-against-experimental-visceral-leishmaniasis
#17
Maritsa Margaroni, Maria Agallou, Evita Athanasiou, Olga Kammona, Costas Kiparissides, Catherine Gaitanaki, Evdokia Karagouni
Visceral leishmaniasis (VL) persists as a major public health problem, and since the existing chemotherapy is far from satisfactory, development of an effective vaccine emerges as the most appropriate strategy for confronting VL. The development of an effective vaccine relies on the selection of the appropriate antigen and also the right adjuvant and/or delivery vehicle. In the present study, the protective efficacy of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), which were surface-modified with a TNFα-mimicking eight-amino-acid peptide (p8) and further functionalized by encapsulating soluble Leishmania infantum antigens (sLiAg) and monophosphoryl lipid A (MPLA), a TLR4 ligand, was evaluated against challenge with L...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28877692/the-use-of-a-p-falciparum-specific-coiled-coil-domain-to-construct-a-self-assembling-protein-nanoparticle-vaccine-to-prevent-malaria
#18
Christopher P Karch, Tais A P F Doll, Sara M Paulillo, Issa Nebie, David E Lanar, Giampietro Corradin, Peter Burkhard
BACKGROUND: The parasitic disease malaria remains a major global public health concern and no truly effective vaccine exists. One approach to the development of a malaria vaccine is to target the asexual blood stage that results in clinical symptoms. Most attempts have failed. New antigens such as P27A and P27 have emerged as potential new vaccine candidates. Multiple studies have demonstrated that antigens are more immunogenic and are better correlated with protection when presented on particulate delivery systems...
September 6, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28876902/amino-acid-functionalised-inorganic-nanoparticles-as-cutting-edge-therapeutic-and-diagnostic-agents
#19
Amlan Chakraborty, Jennifer Carla Boer, Cordelia Selomulya, Magdalena Plebanski
The field of medical diagnostics and therapeutics is being revolutionized by nanotechnology, from targeted drug delivery to cancer immunotherapy. Inorganic nanoparticles are widely used, albeit problems with agglutination, cytotoxicity, free radical generation and instability in some biological environments, limits their utility. Conjugation of biomolecules such as peptides to the surface of nanoparticles can mitigate such problems, as well as confer specialized theranostic (therapeutic and/or diagnostic) properties, useful across biomedical applications such as vaccines, drug delivery and in vivo imaging...
September 6, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28876002/engineering-biodegradable-guanidyl-decorated-peg-pcl-nanoparticles-as-robust-exogenous-activators-of-dcs-and-antigen-cross-presentation
#20
Pan Li, Huijuan Song, Hao Zhang, Pengxiang Yang, Chuangnian Zhang, Pingsheng Huang, Deling Kong, Weiwei Wang
Nanoparticles (NPs)-based adjuvants are attracting much attention in the development of vaccines. Previously, we reported a type of guanidyl-decorated polymeric NPs used as antigen delivery carriers for the first time. However, its un-degradability may restrict potential clinical translation. More importantly, the specific cellular pathway by which dendritic cells (DCs) endocytosed these NPs and the relationship among guanidyl with the antigen cross-presentation, cytokine secretion, and lymph node targeting still remain unclear...
September 21, 2017: Nanoscale
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