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https://www.readbyqxmd.com/read/27935149/the-sorting-receptor-sorcs3-is-a-stronger-regulator-of-glutamate-receptor-functions-compared-to-gabaergic-mechanisms-in-the-hippocampus
#1
Gitte B Christiansen, Katrine Andersen, Sarah Riis, Anders Nykjaer, Ulrik Bølcho, Morten Skovgaard Jensen, Mai Marie Holm
Correct function of glutamate receptors in the postsynaptic density is crucial to synaptic function and plasticity. SorCS3 (sortilin-related receptor CNS expressed 3) is a sorting receptor which previously has been shown to interact with the key postsynaptic proteins; PSD-95 and PICK1. In this study, we employed electrophysiological analyses of acute brain slices combined with immunohistochemistry to define the role of SorCS3 in hippocampal synapses in CA1 and the dentate gyrus. We analyzed a juvenile (P17-21) and a young adult (P55-65) group of animals from a Sorcs3 knockout mouse model...
December 9, 2016: Hippocampus
https://www.readbyqxmd.com/read/27543417/developmental-regulation-of-hippocampal-long-term-depression-by-cofilin-mediated-actin-reorganization
#2
Feng Cao, Zikai Zhou, Xingxiu Pan, Celeste Leung, Wei Xie, Graham Collingridge, Zhengping Jia
Long lasting synaptic plasticity involves both functional and morphological changes, but how these processes are molecularly linked to achieve coordinated plasticity remains poorly understood. Cofilin is a common target of multiple signaling pathways at the synapse and is required for both functional and spine plasticity, but how it is regulated is unclear. In this study, we investigate whether the involvement of cofilin in plasticity is developmentally regulated by examining the role of cofilin in hippocampal long-term depression (LTD) in both young (2 weeks) and mature (2 months) mice...
August 16, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27537764/pick1-regulates-the-expression-and-trafficking-of-ampa-receptors-in-remifentanil-induced-hyperalgesia
#3
Zhifen Wang, Yuan Yuan, Keliang Xie, Xiaohong Tang, Linlin Zhang, Jiying Ao, Nan Li, Yu Zhang, Suqian Guo, Guolin Wang
BACKGROUND: Remifentanil is used widely in clinical anesthesia because it induces more rapid and more common hyperalgesia than other opioid analgesics. Activation of N-methyl-D-aspartate (NMDA) receptors takes a pivotal part in remifentanil-induced hyperalgesia. Like NMDA receptors, the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are excitatory ion glutamate receptors in postsynaptic membrane, which are involved in the transmission of both acute and chronic pain...
September 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27488904/pacsin1-regulates-the-dynamics-of-ampa-receptor-trafficking
#4
Jocelyn Widagdo, Huaqiang Fang, Se Eun Jang, Victor Anggono
Dynamic trafficking of AMPA receptors (AMPARs) into and out of synapses plays an important role in synaptic plasticity. We previously reported that the protein kinase C and casein kinase II substrate in neurons (PACSIN) forms a complex with AMPARs through its interaction with the protein interacting with C-kinase 1 (PICK1) to regulate NMDA receptor (NMDAR)-induced AMPAR endocytosis and cerebellar long-term depression. However, the molecular mechanism by which PACSIN regulates the dynamics of AMPAR trafficking remains unclear...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27460008/a-taspine-derivative-supresses-caco-2-cell-growth-by-competitively-targeting-ephrinb2-and-regulating-its-pathway
#5
Bingling Dai, Wenjie Wang, Yujiao Ma, Rui Liu, Yanmin Zhang
Colorectal cancer is a common gastrointestinal malignancy worldwide and it is a lethal and aggressive malignancy with a dismal prognosis. In the present study, we investigated the effect of taspine derivative 12k on human colorectal cancer targeted at EphrinB2 and its PDZ. The results indicated that 12k could bind to EphrinB2 and showed a higher suppressive effect on EphrinB2/HEK293 than on HEK293 cells. Caco‑2 cells were screened for high expression of EphrinB2. We found that 12k not only significantly decreased Caco‑2 cell viability and colony formation but impaired migration...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27441053/assessment-of-dpy19l2-deletion-in-familial-and-non-familial-individuals-with-globozoospermia-and-dpy19l2-genotyping
#6
Parastoo Modarres, Somayeh Tanhaei, Marziyeh Tavalaee, Kamran Ghaedi, Mohammad Reza Deemeh, Mohammad Hossein Nasr-Esfahani
BACKGROUND: Globozoospermia is a rare syndrome with an incidence of less than 0.1% among infertile men. Researchers have recently identified a large deletion, about 200 kbp, encompassing the whole length of DPY19L2 or mutations in SPATA16 and PICK1 genes associated with globozoospermia. The aim of this study was to analyze the DPY19L2 gene deletion using polymerase chain reaction technique for the exons 1, 48, 11 and 22 as well as break point (BP) "a" in globozoospermic men. MATERIALS AND METHODS: In this experimental study, genome samples were collected from 27 men with globozoospermia (cases) and 36 fertile individuals (controls), and genomic analysis was carried out on each sample...
July 2016: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/27381726/stat3-signal-that-mediates-the-neural-plasticity-is-involved-in-willed-movement-training-in-focal-ischemic-rats
#7
Qing-Ping Tang, Qin Shen, Li-Xiang Wu, Xiang-Ling Feng, Hui Liu, Bei Wu, Xiao-Song Huang, Gai-Qing Wang, Zhong-Hao Li, Zun-Jing Liu
Willed-movement training has been demonstrated to be a promising approach to increase motor performance and neural plasticity in ischemic rats. However, little is known regarding the molecular signals that are involved in neural plasticity following willed-movement training. To investigate the potential signals related to neural plasticity following willed-movement training, littermate rats were randomly assigned into three groups: middle cerebral artery occlusion, environmental modification, and willed-movement training...
July 2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27190058/asic1-mediated-calcium-entry-stimulates-nfatc3-nuclear-translocation-via-pick1-coupling-in-pulmonary-arterial-smooth-muscle-cells
#8
Laura V Gonzalez Bosc, Danielle R Plomaritas, Lindsay M Herbert, Wieslawa Giermakowska, Carly Browning, Nikki L Jernigan
The development of chronic hypoxia (CH)-induced pulmonary hypertension is associated with increased pulmonary arterial smooth muscle cell (PASMC) Ca(2+) influx through acid-sensing ion channel-1 (ASIC1) and activation of the Ca(2+)/calcineurin-dependent transcription factor known as nuclear factor of activated T-cells isoform c3 (NFATc3). Whether Ca(2+) influx through ASIC1 contributes to NFATc3 activation in the pulmonary vasculature is unknown. Furthermore, both ASIC1 and calcineurin have been shown to interact with the scaffolding protein known as protein interacting with C kinase-1 (PICK1)...
July 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27169823/functional-regulation-of-dopamine-d%C3%A2-receptor-through-interaction-with-pick1
#9
Mei Zheng, Xiaohan Zhang, Chengchun Min, Bo-Gil Choi, In-Joon Oh, Kyeong-Man Kim
PICK1, a PDZ domain-containing protein, is known to increase the reuptake activities of dopamine transporters by increasing their expressions on the cell surface. Here, we report a direct and functional interaction between PICK1 and dopamine D₃ receptors (D₃R), which act as autoreceptors to negatively regulate dopaminergic neurons. PICK1 colocalized with both dopamine D₂ receptor (D₂R) and D₃R in clusters but exerted different functional influences on them. The cell surface expression, agonist affinity, endocytosis, and signaling of D₂R were unaffected by the coexpression of PICK1...
September 1, 2016: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27157267/pick1-confers-anti-inflammatory-effects-in-acute-liver-injury-via-suppressing-m1-macrophage-polarization
#10
Juan Xie, Xiaoqin Wu, Qun Zhou, Yang Yang, Yuanyao Tian, Cheng Huang, Xiaoming Meng, Jun Li
Protein interacting with C kinase 1 (PICK1) is a scaffolding protein mainly implicated in neurological diseases, however, the function of PICK1 in acute liver injury (ALI) remains unknown. Our study found a dramatical decrease in mRNA and protein levels of PICK1 in liver tissues and isolated Kupffer cells (KCs) from the liver in mice with ALI. Furthermore, pretreatment the mice with ALI with FSC-231, a pharmacological inhibitor of PICK1, could significantly augment inflammatory response. Furthermore, in vitro studies showed that both lipopolysaccharide (LPS) and interferon gamma (IFN-γ) significantly reduced the expression of PICK1, while IL-4 elevated its expression in RAW 264...
August 2016: Biochimie
https://www.readbyqxmd.com/read/27086357/a-new-mutation-identified-in-spata16-in-two-globozoospermic-patients
#11
Elias ElInati, Camille Fossard, Ozlem Okutman, Houda Ghédir, Samira Ibala-Romdhane, Pierre F Ray, Ali Saad, Sylvianne Hennebicq, Stéphane Viville
PURPOSE: The aim of this study is to identify potential genes involved in human globozoopsermia. METHODS: Nineteen globozoospermic patients (previously screened for DPY19L2 mutations with no causative mutation) were recruited in this study and screened for mutations in genes implicated in human globozoospermia SPATA16 and PICK1. Using the candidate gene approach and the determination of Spata16 partners by Glutathione S-transferase (GST) pull-down four genes were also selected and screened for mutations...
June 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27076447/a-novel-testis-specific-gene-ccdc136-is-required-for-acrosome-formation-and-fertilization-in-mice
#12
Qiang Geng, Liwei Ni, Bin Ouyang, Yanhua Hu, Yu Zhao, Jun Guo
Testis-specific genes are essential for the spermatogenesis in mammalian male reproduction. In this study, we have identified a novel testis-specific gene, Ccdc136 (coiled-coil domain containing 136), from the results of high-throughput gene expression profiling in the developmental stage of mouse testes. Ccdc136 was conserved across species in evolution. Quantitative real-time polymerase chain reaction and Western blot analyses showed that Ccdc136 messenger RNA and protein were extraordinarily expressed in mouse testes, which was first presented at postnatal 3 week and increased in an age-dependent manner before adulthood...
October 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/26970394/multiple-faces-of-protein-interacting-with-c-kinase-1-pick1-structure-function-and-diseases
#13
REVIEW
Yun-Hong Li, Nan Zhang, Ya-Nan Wang, Ying Shen, Yin Wang
Protein interacting with C-kinase 1 (PICK1) has received considerable attention because it is the only protein that contains both PSD-95/DlgA/ZO-1 (PDZ) domain and Bin-Amphiphysin-Rvs (BAR) domain. Through PDZ and BAR domains, PICK1 binds to a large number of membrane proteins and lipid molecules, and is thereby of multiple functions. PICK1 is widely expressed in various tissues, particularly abundant in the brain and testis. In the central nervous system (CNS), PICK1 interacts with numerous neurotransmitters receptors, transporters, ion channels, and enzymes, and controls their trafficking...
September 2016: Neurochemistry International
https://www.readbyqxmd.com/read/26946972/potentiation-of-acid-sensing-ion-channel-activity-by-peripheral-group-i-metabotropic-glutamate-receptor-signaling
#14
Xiong Gan, Jing Wu, Cuixia Ren, Chun-Yu Qiu, Yan-Kun Li, Wang-Ping Hu
Glutamate activates peripheral group I metabotropic glutamate receptors (mGluRs) and contributes to inflammatory pain. However, it is still not clear the mechanisms are involved in group I mGluR-mediated peripheral sensitization. Herein, we report that group I mGluRs signaling sensitizes acid-sensing ion channels (ASICs) in dorsal root ganglion (DRG) neurons and contributes to acidosis-evoked pain. DHPG, a selective group I mGluR agonist, can potentiate the functional activity of ASICs, which mediated the proton-induced events...
May 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26931031/-sperm-acrosome-formation-associated-genes-in-mice-advances-in-studies
#15
REVIEW
Chang-min Niu, Jia-qian Guo, Hai-tao Ma, Zhe Zheng, Ying Zheng
Spermiogenesis is a complex process of differentiation and morphologic alteration, in which sperm acrosome formation is an important stage. Acrosome is an essential component of the sperm head, which develops in four distinct phases: Golgi, cap, acro- somal, and maturation, each supported by precise and orderly regulation of various genes. The regulatory genes which act on Golgi ap- paratus include GOPC, Hrb, SPATA16, PICK1, and CK2α', those involved in the cap phase are Fads2, syntaxin 2, Kdm3a, and UBR7, and participating in acrosomal and maturation phases are KIFC1, Rnf19a, and DPY19L2...
January 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/26925374/secondary-association-of-pdlim5-with-paranoid-schizophrenia-in-emirati-patients
#16
Hamdy Moselhy, Valsamma Eapen, Nadia A Akawi, Ali Younis, Badr Salih, Aws R Othman, Said Yousef, Raymond A Clarke, Bassam R Ali
Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification...
September 2015: Meta Gene
https://www.readbyqxmd.com/read/26868290/syntabulin-regulates-the-trafficking-of-pick1-containing-vesicles-in-neurons
#17
Junyu Xu, Na Wang, Jian-Hong Luo, Jun Xia
PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein that interacts with diverse membrane proteins. PICK1 has been shown to regulate the clustering and membrane localization of synaptic receptors such as AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, metabotropic glutamate receptor 7, and ASICs (acid-sensing ion channels). Moreover, recent evidence suggests that PICK1 can mediate the trafficking of various vesicles out from the Golgi complex in several cell systems, including neurons...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26807999/a-computational-model-for-the-ampa-receptor-phosphorylation-master-switch-regulating-cerebellar-long-term-depression
#18
Andrew R Gallimore, A Radu Aricescu, Michisuke Yuzaki, Radu Calinescu
The expression of long-term depression (LTD) in cerebellar Purkinje cells results from the internalisation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) from the postsynaptic membrane. This process is regulated by a complex signalling pathway involving sustained protein kinase C (PKC) activation, inhibition of serine/threonine phosphatase, and an active protein tyrosine phosphatase, PTPMEG. In addition, two AMPAR-interacting proteins-glutamate receptor-interacting protein (GRIP) and protein interacting with C kinase 1 (PICK1)-regulate the availability of AMPARs for trafficking between the postsynaptic membrane and the endosome...
January 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/26702130/pick1-calcineurin-suppress-asic1-mediated-ca2-entry-in-rat-pulmonary-arterial-smooth-muscle-cells
#19
Lindsay M Herbert, Carlos H Nitta, Tracylyn R Yellowhair, Carly Browning, Laura V Gonzalez Bosc, Thomas C Resta, Nikki L Jernigan
Acid-sensing ion channel 1 (ASIC1) contributes to Ca(2+) influx and contraction in pulmonary arterial smooth muscle cells (PASMC). ASIC1 binds the PDZ (PSD-95/Dlg/ZO-1) domain of the protein interacting with C kinase 1 (PICK1), and this interaction is important for the subcellular localization and/or activity of ASIC1. Therefore, we first hypothesized that PICK1 facilitates ASIC1-dependent Ca(2+) influx in PASMC by promoting plasma membrane localization. Using Duolink to determine protein-protein interactions and a biotinylation assay to assess membrane localization, we demonstrated that the PICK1 PDZ domain inhibitor FSC231 diminished the colocalization of PICK1 and ASIC1 but did not limit ASIC1 plasma membrane localization...
March 1, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/26617735/down-regulation-of-asics-current-and-the-calcium-transients-by-disrupting-pick1-protects-primary-cultured-mouse-cortical-neurons-from-ogd-rep-insults
#20
Jin Cheng, Yu Chen, Hui Xing, Hua Jiang, Xihong Ye
Acid sensing ion channels (ASICs), activated by lowering extracellular pH, play an important role in normal synaptic transmission in brain and in the pathology of brain ischemia. ASICs activation involving in glutamate receptor-independent ischemic brain injury has been generally accepted, and PICK1 is recently shown to be one of partner proteins interacting with ASICs through its PDZ domain. Here we showed that ASICs and PICK1 played key roles in OGD-Rep process. In wild-type cultured cortical neurons, not only the amplitude of ASICs current and the calcium transients induced by acidosis were both increased after OGD-Rep, but also the total protein levels of ASIC1 and ASIC2a were up-regulated progressively after ischemia insults, indicating that ASICs play a vital role in neuronal ischemia...
2015: International Journal of Clinical and Experimental Pathology
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