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Porocarcinoma

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https://www.readbyqxmd.com/read/27898349/porocarcinoma-a-systematic-review-of-literature-with-a-single-case-report
#1
Abdulwahid M Salih, F H Kakamad, Rawand A Essa, Goran M Rauf, Masrur S A, Shvan H M, Rawezh Q S, Hunar A H, Dahat A H, Snur Othman
INTRODUCTION: Eccrine porocarcinoma is a very rare type of skin cancer. It is an aggressive dermatological malignancy. We presented a 62-year-old male with long history of a mass in left forearm complicated by distant metastasis and death. A rapid review of literature has been presented. CONCLUSION: Eccrine porocarcinoma is a rare but aggressive type of skin disease. It may arise de novo or complicate a benign skin lesion. Wide local resection is recommended.
November 18, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27832810/eccrine-porocarcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#2
Ayako Fujimine-Sato, Masafumi Toyoshima, Shogo Shigeta, Asami Toki, Takashi Kuno, Izumi Sato, Mika Watanabe, Hitoshi Niikura, Nobuo Yaegashi
BACKGROUND: Malignant tumors arising from the vulva account for only 0.6 % of all cancers in female patients. The predominant histologic type, representing about 90 % of these malignancies, is squamous cell carcinoma. Eccrine porocarcinoma is a rare malignant tumor arising from sweat glands. The incidence of eccrine porocarcinoma is estimated at 0.005-0.01 % of all cutaneous tumors. To the best of our knowledge, only seven previous cases of vulvar eccrine porocarcinoma have been reported in the English-language literature...
November 10, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27721767/metastatic-eccrine-porocarcinoma-a-rare-case-of-successful-treatment
#3
Hiren Mandaliya, Ina Nordman
The successful treatment of the rare malignancy eccrine porocarcinoma (EP) is extremely challenging, often not rewarding and when associated with metastatic disease, therapy results are disappointing. We present a unique case of treatment response of metastatic EP, with a significant disease-free interval. The patient has remained in clinical and radiological remission for 36 months since diagnosis of metastatic disease.
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27593487/eccrine-porocarcinoma-presenting-as-a-hand-cyst
#4
Amer Raheemullah, Shyam Allamaneni, Steven Weber, Ranjodh Singh
Eccrine porocarcinoma is a rare tumor that arises from the epithelium of the eccrine ducts, with a tendency for metastatic spread and a high rate of local recurrence after excision. It was first described in 1963 by Pinkus and Mehregan and can present clinically as a nodule, erosive plaque or a polypoid growth that may ulcerate. The variable clinical appearance of these lesions can make diagnosis challenging and could delay appropriate treatment. If metastasis occurs the prognosis is poor, with a reported mortality rate of up to 80%...
September 1, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27502253/characteristics-of-eccrine-tumors-in-a-tertiary-institution-a-5-year-retrospective-study
#5
Peiqi Su, Jun Khee Heng, Derrick Chen Wee Aw, Kong Bing Tan
Eccrine tumors are adnexal tumors with a varied clinical presentation and wide histological spectrum. This study aims to consolidate data on the clinical characteristics of eccrine tumors to help improve clinical acumen and management of such tumors. Histopathological records from January 2008 to December 2012 were retrieved. Clinical characteristics of the tumor including site, appearance, symptoms, color, duration prior to presentation, and clinical and histological diagnosis were recorded. Eighty-four patients with eccrine tumors were identified, with seven main types of tumors recognized-hidradenoma (33...
2016: Skinmed
https://www.readbyqxmd.com/read/27307184/cutaneous-collision-tumor-associated-with-porocarcinomatous-and-angiosarcomatous-components-a-potential-diagnostic-pitfall
#6
Rafael Parra-Medina, Mario A Melo-Uribe, Oscar Messa-Botero, Samuel D Morales
Sarcomatoid eccrine porocarcinoma (SEP) is a very rare malignancy including epithelial and mesenchymal components exhibiting pleomorphic cells, nuclear hyperchromasia, and high mitotic activity in both elements. To date, only 6 cases of this uncommon neoplasm have been reported, corresponding to women over 70 years of age with ulcerated skin lesions. The authors describe the first sarcomatoid eccrine porocarcinoma in a 75-year-old male patient with a right hallux lesion, presenting a collision tumor with a mixed population of epithelial cells and a spindle cell angiosarcomatous mesenchymal component each expressing distinct and nonoverlapping morphologic and immunohistochemical features of epithelial and mesenchymal differentiation...
September 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27302529/porocarcinoma-scalp-with-high-risk-features-treated-with-surgery-and-adjuvant-radiotherapy-a-case-report-and-review-of-literature
#7
Wineeta Melgandi, Rony Benson, Abdul Hakin, Suman Bhasker
Eccrine porocarcinoma is a rare malignant sweat gland tumor arising from the intra dermal part of the gland and accounts for only 0.005% of all epithelial cutaneous tumors. Commonly involved site includes extremities and face. Scalp is a rare site for porocarcinoma with less than 20 reported cases so far. Wide local excision with clear margins remains the treatment of choice. Review of literature revealed a local recurrence rate of 37.5% and a nodal involvement risk of 20%. Porocarcinoma of the scalp is peculiar in that the primary tumor may be large at presentation, making surgery with adequate margins difficult...
September 2016: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/27176862/treatment-of-porocarcinoma-with-mohs-micrographic-surgery-the-mayo-clinic-experience
#8
Stanislav N Tolkachjov, Thomas L Hocker, Michael J Camilleri, Christian L Baum
BACKGROUND: Eccrine porocarcinoma (EPC) is a rare malignant adnexal neoplasm with reported metastatic potential and undefined optimal treatment. OBJECTIVE: This study reviews the clinical characteristics and outcomes of patients with EPC treated with Mohs micrographic surgery (MMS). MATERIALS AND METHODS: The authors performed a retrospective chart review of patients with EPC treated by MMS at the Mayo Clinic from 1995 to 2013, recording patient demographics, tumor characteristics, MMS stages to clearance, follow-up, recurrence, metastasis, and mortality...
June 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27159948/immunohistological-expression-of-p16ink4a-is-commonly-present-both-in-benign-and-malignant-sweat-gland-neoplasias
#9
Jun Tsujita, Yumiko Kaku, Toshio Ichiki, Ayaka Eto, Hiromi Maemura, Akiko Otsuka, Risa Nakaie, Noriko Kitagawa, Yuka Morioka, Tomoyo Matsuda, Maiko Yoshida, Masutaka Furue
The expression of p16INK4a has been reported to be a significant marker for malignant transformation of epidermal tumors. However, little is known about sweat gland tumors. We examined the immunohistological expression of p16INK4a in benign and malignant sweat gland tumors. The ductal and acrosyringial portion of normal eccrine glands were positively stained with p16INK4a while it was negative in the normal epidermis. Moderate to strong expression of p16INK4a was found in 16 of 17 eccrine poromas, 4 of 5 hidradenomas, 3 of 3 syringocystadenoma papilliferums, 2 of 2 mixed tumors, and 3 of 3 syringomas...
December 2015: Fukuoka Igaku Zasshi, Hukuoka Acta Medica
https://www.readbyqxmd.com/read/27153442/immunoexpression-of-androgen-receptors-in-poroid-neoplasms
#10
Angel Fernandez-Flores, David S Cassarino
Some poroid neoplasias are known to show apocrine differentiation (ie, differentiation toward the folliculosebaceous and the apocrine units). In this sense, it is somewhat surprising that the immunoexpression of androgen receptors (ARs) has not been investigated yet in poroid neoplasias. In this study, we examined the immunoexpression of ARs in 40 poroid neoplasms (8 porocarcinomas and 32 poromas). We found intense and diffuse immunoexpression of ARs in 1 porocarcinoma. In addition, 7 poromas and 2 porocarcinomas showed focal immunoexpression of ARs...
May 5, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27085107/eccrine-porocarcinoma-presenting-as-an-abdominal-wall-mass-in-a-patient-with-ulcerative-colitis-a-rare-case-report
#11
Narendrasinh Parmar, Mohamed Mohamed, Adel Elmoghrabi, Michael McCann
INTRODUCTION: Eccrine porocarcinoma (EPC) is a rare malignancy of eccrine sweat glands. It is often seen during the sixth to eighth decades of life. We report the first case of eccrine porocarcinoma arising on the abdomen of a 21-year-old patient with ulcerative colitis. CASE PRESENTATION: A 21-Year-old female presented to emergency department with a one month history of an enlarging mass over left lower abdomen. Abdominal examination revealed a slightly erythematous, nodular and non-mobile firm mass in left lower quadrant...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27067779/porocarcinomas-harbor-recurrent-hras-activating-mutations-and-tumor-suppressor-inactivating-mutations
#12
Paul W Harms, Daniel H Hovelson, Andi K Cani, Kei Omata, Michaela J Haller, Michael L Wang, David Arps, Rajiv M Patel, Douglas R Fullen, Min Wang, Javed Siddiqui, Aleodor Andea, Scott A Tomlins
Porocarcinomas are a rare eccrine carcinoma with significant metastatic potential. Oncogenic drivers of porocarcinomas have been underexplored, with PIK3CA-activating mutation reported in 1 case. We analyzed 5 porocarcinomas by next-generation sequencing using the DNA component of the Oncomine Comprehensive Assay, which provides data on copy number changes and mutational events in 126 cancer-relevant genes through multiplex polymerase chain reaction. We detected an average of 3.3 high-confidence nonsynonymous mutations per tumor (range, 1-6), including a spectrum of oncogenic activation and tumor suppressor inactivation events...
May 2016: Human Pathology
https://www.readbyqxmd.com/read/27042472/primary-axillary-porocarcinoma-a-rare-cutaneous-tumour
#13
Nalli R Sumitra Devi, K Valarmathi, Mary Lilly, Selvi Satish, Nidhi Mishra
Eccrine porocarcinoma, a rare cutaneous malignant tumour accounts for a fraction of sweat gland tumours. This tumour is found to originate from the intraepithelial parts of the sweat glands. It commonly involves the lower extremities in elderly patients and carries an aggressive behaviour. Cutaneous and visceral metastasis can occur and hence prompt treatment is mandatory. Surgical excision is the mainstay of treatment modality. We hereby present a case of eccrine porocarcinoma in a 50-year-old male in the right axillary region presenting as a verrucous lesion...
February 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26994694/detection-of-merkel-cell-polyomavirus-and-human-papillomavirus-dna-in-porocarcinoma
#14
Carmelo Urso, Federica Pierucci, Mauro Sollai, Rosaria Arvia, Daniela Massi, Krystyna Zakrzewska
BACKGROUND: Increasing evidences support the role of Merkel cell polyomavirus (MCPyV) and human papillomavirus (HPV) in non-cutaneous and cutaneous tumours. Porocarcinoma is a rare malignant neoplasm that arises from the intraepidermal ductal portion of the eccrine sweat glands. The aetiology of porocarcinoma is largely unknown and no systematic studies have been done to investigate the implication of infectious agents in the pathogenesis of this tumour. OBJECTIVES: To investigate the possible association between MCPyV and/or HPV infection and porocarcinoma...
May 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/26914519/expression-of-epidermal-stem-cell-markers-in-skin-and-adnexal-malignancies
#15
S R Quist, M Eckardt, A Kriesche, H P Gollnick
BACKGROUND: Epidermal stem cells are multipotent cells that maintain the skin epidermis. Potential markers for stem cells have been identified in mammalian skin from mouse experiments; however, it is unclear if stem cells also contribute to tumour formation in human skin. OBJECTIVES: To investigate the expression of potential stem cell markers, such as leucine-rich repeat-containing G protein-coupled receptor (Lgr) 5, Lgr6, leucine-rich repeats and immunoglobulin-like domain protein 1 (Lrig1) and cytokeratin 15 (CK15) in basal cell carcinomas and tumours of the skin appendages...
September 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/26894080/eccrine-porocarcinoma-of-the-scalp-a-rare-case-report-with-review-of-literature
#16
Smita Surendra Masamatti, Aparna Narasimha, Amoolya Bhat, Vijaya Chowdappa
Eccrine porocarcinoma (EPC) is a potentially lethal neoplasm of the skin that arises from the intraepidermal portion of the eccrine sweat glands. It was previously known as eccrine adenocarcinoma or malignant eccrine poroma. It commonly occurs between 60 to 80 years of age, usually arising from hands and feet. However, few case reports on involvement of rare sites such as scalp, face and eyelids are present in literature. We herein report an unusual case of porocarcinoma arising on the right parieto occipital region of scalp in a 29-year-old young female patient...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26595821/gata3-expression-in-normal-skin-and-in-benign-and-malignant-epidermal-and-cutaneous-adnexal-neoplasms
#17
Richard B Mertens, Mariza N de Peralta-Venturina, Bonnie L Balzer, David P Frishberg
Initial investigations reported GATA3 to be a sensitive and relatively specific marker for mammary and urothelial carcinomas. Recently, GATA3 expression has been described in several other epithelial tumors. However, there has been only limited investigation of GATA3 expression in cutaneous epithelial tumors. The objective of this study was to examine the immunohistochemical expression of GATA3 in a wide variety of cutaneous epithelial neoplasms. GATA3 expression was evaluated in 99 benign and 63 malignant cutaneous epithelial tumors...
December 2015: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26566927/eccrine-porocarcinoma-with-extensive-cutaneous-metastases
#18
Andrea Montes-Torres, Alejandra Pérez-Plaza, Mar Llamas-Velasco, Carlos Gordillo, Diego De Argila, Carmen García-García, Javier Fraga, Alicia Marín, Ana Isabel Ballesteros, Esteban Daudén
BACKGROUND: Eccrine porocarcinoma (EPC) is an uncommon malignant neoplasm that originates in the intraepidermal portion of the eccrine sweat duct. Although porocarcinoma is a slow-growing tumor, up to 20% of cases can metastasize to regional lymph nodes, thus increasing mortality. METHODS: We describe the clinical and histopathological features and clinical course of three cases of extensive metastatic EPC diagnosed in our department over the last 10 years. RESULTS: All three patients were women aged 89-96 years...
March 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/26516328/eccrine-porocarcinoma-of-scalp-a-rare-case-report
#19
Subrata Pal, Jyoti Prakash Phukan, Sanjay Sengupta, Anuradha Sinha
Eccrine porocarcinoma is a rare malignant adnexal tumor of ductal portion of eccrine sweat gland. It occurs commonly in the lower extremities and rarely in scalp, face, ear, trunk and upper extremities. This survey presents a classic case of eccrine porocarcinoma of scalp in a 58 yr old male patient, presenting as cauliflower like growth over parietal aspect of scalp.
2015: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/26449497/cd117-kit-is-a-useful-immunohistochemical-marker-for-differentiating-porocarcinoma-from-squamous-cell-carcinoma
#20
Keisuke Goto, Toshihiro Takai, Takaya Fukumoto, Takashi Anan, Tetsunori Kimura, Shin-ichi Ansai, Yoshimi Oshitani, Yozo Murata, Toshiko Sakuma, Takanori Hirose
BACKGROUND: Distinguishing porocarcinoma from squamous cell carcinoma (SCC) is clinically significant but can pose a diagnostic dilemma. The present study sought to confirm the diagnostic utility of CD117 immunohistochemistry in distinguishing porocarcinoma from SCC and to examine histologic, carcinoembryonic antigen (CEA) immunohistochemical and CA19-9 immunohistochemical differences between these tumors. METHODS: Immunostaining with anti-CD117, anti-CEA and anti-CA19-9 antibodies was performed for 22 porocarcinomas and 31 SCCs...
March 2016: Journal of Cutaneous Pathology
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