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https://www.readbyqxmd.com/read/28901534/evaluation-of-the-efficacy-and-safety-of-oral-isotretinoin-versus-topical-isotretinoin-in-the-treatment-of-plane-warts-a-randomized-open-trial
#1
Gagan J Kaur, Balvinder K Brar, Sumir Kumar, Sukhmani K Brar, Baltej Singh
BACKGROUND: Plane warts are a common therapeutic problem. Our aim was to assess the efficacy and safety of oral versus topical isotretinoin in the treatment of plane warts. METHODS: Forty patients with multiple plane warts were randomized into two groups. Group A was treated with oral isotretinoin capsules in the dose of 0.5 mg/kg/d and Group B with topical isotretinoin 0.05% in gel formulation once daily at night. Treatment was given to the patients for 3 months or until the complete clearance of lesions, whichever was earlier...
September 13, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28899625/cost-effectiveness-of-hpv-vaccination-in-the-context-of-high-cervical-cancer-incidence-and-low-screening-coverage
#2
Triin Võrno, Katrin Lutsar, Anneli Uusküla, Lee Padrik, Terje Raud, Rainer Reile, Oliver Nahkur, Raul-Allan Kiivet
BACKGROUND: Estonia has high cervical cancer incidence and low screening coverage. We modelled the impact of population-based bivalent, quadrivalent or nonavalent HPV vaccination alongside cervical cancer screening. METHODS: A Markov cohort model of the natural history of HPV infection was used to assess the cost-effectiveness of vaccinating a cohort of 12-year-old girls with bivalent, quadrivalent or nonavalent vaccine in two doses in a national, school-based vaccination programme...
September 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28898279/lifestyle-factors-and-oncogenic-papillomavirus-infection-in-a-high-risk-male-population
#3
Elena Lopez-Diez, Sonia Perez, Manuel Carballo, Amparo Iñarrea, Angel de la Orden, Maximo Castro, Moises Rodríguez, Sheila Almuster, Ruben Montero, Miguel Perez, Jorge Sanchez, Antonio Ojea
BACKGROUND: High risk human papillomavirus (HR-HPV) infection in males is a health issue with implications for HPV-related lesions in their partners. The identification of risk factors for male infection may improve our understanding of HR-HPV transmission and prevention. The aim of this study was to evaluate the relationships between lifestyle, genital warts and HR-HPV infection. The study was focused on men with an increased risk of HR-HPV infection: male sexual partners of women diagnosed with high-grade squamous intraepithelial cervical lesions...
2017: PloS One
https://www.readbyqxmd.com/read/28893935/tumour-virus-vaccines-hepatitis-b-virus-and-human-papillomavirus
#4
REVIEW
Margaret Stanley
Two of the most important human oncogenic viruses are hepatitis B virus (HBV) and human papillomavirus (HPV). HBV infection has been preventable by vaccination since 1982; vaccination of neonates and infants is highly effective, resulting already in decreased rates of new infections, chronic liver disease and hepato-cellular carcinoma. Nonetheless, HBV remains a global public health problem with high rates of vertical transmission from mother to child in some regions. Prophylactic HPV vaccines composed of virus-like particles (VLPs) of the L1 capsid protein have been licensed since 2006/2007...
October 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28885314/treatment-of-multiple-resistant-and-or-recurrent-cutaneous-warts-with-squaric-acid-dibutylester-a-randomized-double-blind-vehicle-controlled-clinical-trial
#5
Federica DallʼOglio, Maria Luca, Sebastiano Barresi, Giuseppe Micali
BACKGROUND: Contact immunotherapy with squaric acid dibutylester (SADBE) for cutaneous warts has been reported to be effective, although no controlled studies are available so far. OBJECTIVE: The aim of this study was to evaluate the efficacy of SADBE on cutaneous warts by a randomized, double-blind, vehicle-controlled, clinical trial. METHODS: Thirty-six patients were randomly assigned to SADBE (18 cases) or vehicle (18 cases) group. At 8 weeks, subjects were clinically evaluated for number/size reduction rate and for Investigator Global Assessment...
September 2017: Dermatitis
https://www.readbyqxmd.com/read/28884079/podophyllotoxin-a-novel-potential-natural-anticancer-agent
#6
REVIEW
Hamidreza Ardalani, Amir Avan, Majid Ghayour-Mobarhan
OBJECTIVE: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. MATERIALS AND METHODS: Google scholar, PubMed and Scopus were searched for literatures which have studied identification, characterization, fermentation and therapeutic effects of PTOX and published in English language until end of 2016...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28878573/cost-effectiveness-of-human-papillomavirus-vaccination-in-germany
#7
Oliver Damm, Johannes Horn, Rafael T Mikolajczyk, Mirjam E E Kretzschmar, Andreas M Kaufmann, Yvonne Deleré, Bernhard Ultsch, Ole Wichmann, Alexander Krämer, Wolfgang Greiner
BACKGROUND: The aim of this study was to assess the cost-effectiveness of human papillomavirus (HPV) vaccination in addition to the current cervical cancer screening programme in Germany using a dynamic transmission model. METHODS: Based on a mathematical model simulating the transmission dynamics and the natural history of HPV infection and associated diseases (cervical intraepithelial neoplasia, cervical cancer, and genital warts), we estimated the epidemiological and economic consequences of HPV vaccination with both the quadrivalent and bivalent vaccines...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28876320/understanding-the-effects-of-forced-sex-on-sexually-transmitted-disease-acquisition-and-sexually-transmitted-disease-care-findings-from-the-national-survey-of-family-growth-2011-2013
#8
Kathryn A Brookmeyer, Oscar Beltran, Neetu Abad
BACKGROUND: Although there is evidence for heightened sexually transmitted disease (STD) acquisition among women who experienced sexual violence, little is known about their patterns of STD testing, STD diagnosis, and STD treatment. METHODS: Data was drawn from cycle eight of the National Survey of Family Growth (2011-2013). Logistic regression analyses used SUDAAN to examine the link between forced sex and risky sexual behavior as well as forced sex and STD testing, diagnoses, treatment, and connection to care...
June 17, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28876315/recurrence-of-human-papillomavirus-external-genital-wart-infection-among-high-risk-adults-in-montr%C3%A3-al-canada
#9
Réjean Thomas, Marc Steben, Zoë Greenwald, Melissa Stutz, Caroline Rodier, Fern DeAngelis, Emmanouil Rampakakis
OBJECTIVES: The incidence of recurrent genital warts is not well characterized; this is especially true in a post-human papillomavirus (HPV) vaccination era. The objectives of this study were to assess the incidence of subsequent HPV-related external genital warts (EGW) episodes in high-risk male and female adults, as well as ascertain patient profile and disease characteristics, in a real-world Canadian sexual health clinical setting. METHODS: Retrospective chart review study conducted at Clinique médicale l'Actuel, a sexual health clinic in Montréal, Québec, Canada...
June 20, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28871935/topical-imiquimod-is-an-effective-and-safe-drug-for-molluscum-contagiosum-in-children
#10
George Badavanis, Efstathia Pasmatzi, Alexandra Monastirli, Sophia Georgiou, Dionysios Tsambaos
Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. In adults, the skin lesions are predominantly located in the genital region, whereas in children they are found on the trunk, the extremities, and the face...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28871932/a-12-year-old-girl-with-severe-plaque-psoriasis-and-down-syndrome-treated-successfully-with-etanercept
#11
Michał Adamczyk, Małgorzata Michalska-Jakubus, Dorota Krasowska
The association between Down syndrome and psoriasis is unclear. Immunological abnormalities that present in individuals with Down syndrome result in mild immune debilitation, thus the risk of infectious complications during immunosuppressive therapy might be higher in this group of patients. We present a case of 12-year-old girl with severe plaque psoriasis and Down syndrome, who was initially treated with cyclosporine with good response. However, the drug was withdrawn due to massive viral warts development and loss of efficacy...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28870790/adjuvant-intensity-modulated-whole-abdominal-radiation-therapy-for-high-risk-patients-with-ovarian-cancer-international-federation-of-gynecology-and-obstetrics-stage-iii-first-results-of-a-prospective-phase-2-study
#12
Nathalie Arians, Meinhard Kieser, Laura Benner, Nathalie Rochet, Sonja Katayama, Florian Sterzing, Klaus Herfarth, Kai Schubert, Lars Schröder, Christina Leitzen, Andreas Schneeweiss, Christof Sohn, Jürgen Debus, Katja Lindel
PURPOSE: To assess treatment tolerance and toxicity rates of consolidative whole-abdominal radiation therapy (WART) following cytoreductive surgery and carboplatin/paclitaxel chemotherapy in high-risk patients with advanced ovarian cancer (International Federation of Gynecology and Obstetrics stage III) using intensity modulated radiation therapy. METHODS AND MATERIALS: The OVAR-IMRT-02 study is a multicenter, single-arm, phase 2 trial. Twenty patients with optimally debulked ovarian cancer (International Federation of Gynecology and Obstetrics stage III) with complete remission after chemotherapy were treated with intensity modulated WART as a consolidation therapy...
July 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28868008/epidermolytic-acanthoma-on-fingers-mimicking-flat-warts
#13
Salinee Rojhirunsakool, Suthep Jirasuthat, Kumutnart Chanprapaph
Epidermolytic acanthoma (EA) is a benign cutaneous condition. It is characterized by warty or flat-topped, keratotic papules that show epidermolytic hyperkeratosis in histology. EA has been described to occur in various locations, namely the trunk, face, and genitoscrotal area. However, it has not been previously reported to involve the palmar area. To the best of our knowledge, we present the first reported case of EA involving the palms and fingers.
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28868001/efficacy-and-tolerability-of-polyphenon-e-in-difficult-to-treat-multiple-genital-warts-in-an-hiv-positive-male-subject
#14
Mauro Grandolfo, Massimo Milani
A 55-year-old man, nonsmoker, with a HIV-positive history came to our attention in February 2017. He was on treatment with Stribild(TM), 1 capsule daily (150 mg elvitegravir, 150 mg cobicistat, 200 mg emtricitabine, and 245 mg tenofovir disoproxil). The CD4+/CD8+ cellular count was 326/µL (normal values: 404-1,612); the CD3+/CD8+ cellular count was 819/µL (normal values: 220-1,219). The CD4/CD8 ratio was 0.40 (normal value: >1). Several typical genital wart lesions were present at the penis shaft and at the level of the neck and the corona of glans...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28867768/keratinocyte-differentiation-dependent-human-papillomavirus-gene-regulation
#15
REVIEW
Sheila V Graham
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte. The normal replication cycle involves an early and a late phase. The early phase encompasses viral entry and initial genome replication, stimulation of cell division and inhibition of apoptosis in the infected cell. Late events in the HPV life cycle include viral genome amplification, virion formation, and release into the environment from the surface of the epithelium...
August 30, 2017: Viruses
https://www.readbyqxmd.com/read/28866637/detection-of-human-papillomavirus-in-urine-among-heterosexual-men-in-relation-to-location-of-genital-warts-and-circumcision-status
#16
Ei T Aung, Christopher K Fairley, Sepehr N Tabrizi, Jennifer A Danielewski, Jason J Ong, Marcus Y Chen, Catriona S Bradshaw, Eric P F Chow
OBJECTIVE: Human papillomavirus (HPV) surveillance is important to monitor the effectiveness of national HPV vaccination programmes. Positivity of HPV in urine in men varies with different sampling methods. We aimed to determine the positivity for detection of HPV-6/11 in urine samples among men in relation to the position of genital warts and circumcision status. METHOD: We analysed stored chlamydia-positive urine specimens in young heterosexual men aged less than 25 years attending Melbourne Sexual Health Centre, Australia, between 2004 and 2015, for HPV genotypes...
September 2, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28858397/model-based-approach-to-predict-adherence-to-protocol-during-antiobesity-trials
#17
Vishnu D Sharma, François P Combes, Majid Vakilynejad, Gezim Lahu, Lawrence J Lesko, Mirjam N Trame
Development of antiobesity drugs is continuously challenged by high dropout rates during clinical trials. The objective was to develop a population pharmacodynamic model that describes the temporal changes in body weight, considering disease progression, lifestyle intervention, and drug effects. Markov modeling (MM) was applied for quantification and characterization of responder and nonresponder as key drivers of dropout rates, to ultimately support the clinical trial simulations and the outcome in terms of trial adherence...
August 31, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28853393/parallel-activin-and-bmp-signaling-coordinates-r7-r8-photoreceptor-subtype-pairing-in-the-stochastic-drosophila-retina
#18
Brent S Wells, Daniela Pistillo, Erin Barnhart, Claude Desplan
Drosophila color vision is achieved by comparing outputs from two types of color-sensitive photoreceptors, R7 and R8. Ommatidia (unit eyes) are classified into two subtypes, known as 'pale' or 'yellow', depending on Rhodopsin expression in R7 and R8. Subtype specification is controlled by a stochastic decision in R7 and instructed to the underlying R8. We find that the Activin receptor Baboon is required in R8 to receive non-redundant signaling from the three Activin ligands, activating the transcription factor dSmad2...
August 30, 2017: ELife
https://www.readbyqxmd.com/read/28852295/safety-and-efficacy-of-intralesional-vitamin-d3-in-cutaneous-warts-an-open-uncontrolled-trial
#19
Manjunath Kavya, Basavapura Madegowda Shashikumar, Muddanahalli Rajegowda Harish, Bhadbhade P Shweta
BACKGROUND: Cutaneous warts are treated primarily with destructive methods such as cryotherapy or electrocautery. These modalities of treatment are time-consuming and may be associated with scarring in multiple warts. Immunotherapy is emerging as a new modality of treatment which acts on enhancing cell-mediated immunity against human papillomavirus for clearance of both treated and distant warts. AIMS: This study aims to evaluate the safety and efficacy of intralesional Vitamin D3 for the treatment of cutaneous warts...
April 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28835241/rectal-carcinoma-and-multiple-gastrointestinal-stromal-tumors-gist-of-the-small-intestine-in-a-patient-with-neurofibromatosis-type-1-a-case-report
#20
Yuhei Hakozaki, Shinichi Sameshima, Teppei Tatsuoka, Takashi Okuyama, Yukinori Yamagata, Tamaki Noie, Masatoshi Oya, Akiko Fujii, Yoshihiko Ueda, Chieko Shimura, Kazumoto Katagiri
BACKGROUND: Neurofibromatosis type 1 (NF1) is an autosomally dominant inherited disorder characterized by multiple pigmented skin spots (café-au-lait spots) and neurofibroma. NF1 is associated with a wide variety of benign or malignant tumors. We report a NF1 patient who received surgical treatment for rectal carcinoma and multifocal small intestinal gastrointestinal stromal tumors (GISTs). CASE PRESENTATION: A 70-year-old female patient with NF1 was referred to our hospital after a positive fecal occult blood test...
August 23, 2017: World Journal of Surgical Oncology
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