keyword
https://read.qxmd.com/read/38495666/the-impact-of-pregnancy-in-patients-with-thoracic-aortic-disease-epidemiology-risk-assessment-and-management-considerations
#21
REVIEW
Valeria E Duarte, Jessica N Richardson, Michael N Singh
Thoracic aortic disease (TAD) poses substantial risks during pregnancy, particularly for women with genetic conditions such as Marfan syndrome, Loeys-Dietz syndrome, and vascular Ehlers-Danlos syndrome. This review examines the epidemiology, risk assessment, and management of TAD in pregnancy. Preconception counseling is vital considering the hereditary nature of TAD and potential pregnancy-related complications. Genetic testing and imaging surveillance aid in risk assessment. Medical management, including beta-blockade and strict blood pressure control, is essential throughout pregnancy...
2024: Methodist DeBakey Cardiovascular Journal
https://read.qxmd.com/read/38495519/antimicrobial-resistance-in-enterobacterales-infections-among-children-in-sub-saharan-africa-a-systematic-review-and-meta-analysis
#22
JOURNAL ARTICLE
Morgane Kowalski, Basilice Minka Obama, Gaud Catho, Juan Emmanuel Dewez, Arnaud Merglen, Micaela Ruef, Diego O Andrey, Nasreen Hassoun-Kheir, Marlieke E A de Kraker, Christophe Combescure, Stephane Emonet, Annick Galetto-Lacour, Noémie Wagner
BACKGROUND: The burden of antimicrobial resistance (AMR) has been estimated to be the highest in sub-Saharan Africa (SSA). The current study estimated the proportion of drug-resistant Enterobacterales causing infections in SSA children. METHODS: We searched MEDLINE/PubMed, Embase and the Cochrane Library to identify retrospective and prospective studies published from 01/01/2005 to 01/06/2022 reporting AMR of Enterobacterales causing infections in sub-Saharan children (0-18 years old)...
April 2024: EClinicalMedicine
https://read.qxmd.com/read/38495224/integration-of-a-respiratory-function-monitor-into-newborn-positive-pressure-ventilation-training-development-of-a-standardised-training-intervention
#23
JOURNAL ARTICLE
C M Ni Chathasaigh, L Smiles, E O'Currain, A E Curley
OBJECTIVE: One in twenty newborns require resuscitation with positive pressure ventilation (PPV) at birth. Newborn face mask ventilation is often poorly performed. To address this, the potential role of respiratory function monitors (RFM) in newborn resuscitation training has been highlighted. The objective of this study was to develop a standardised training intervention on newborn PPV using an RFM with a simple visual display to identify and correct suboptimal ventilations. METHODS: We adapted the framework from a simulation development guideline to create a hands-on intervention on newborn PPV using an RFM with simple visual feedback (Monivent NeoTraining)...
June 2024: Resuscitation plus
https://read.qxmd.com/read/38495026/adjusting-and-validating-a-procedure-for-parenteral-anaesthesia-in-neonatal-mice
#24
JOURNAL ARTICLE
Rafael Goterris-Cerisuelo, Sandra Sanahuja-Irene, María J Sánchez-Catalán, Fernando Martínez-García
For neonatal pups, parenteral anaesthesia is said to be not reliable as low doses induce no anaesthesia whereas high doses render high mortality rates. In this work we have adapted parenteral anaesthesia procedures approved for pups >7 days of age, to anaesthetize neonatal animals (postnatal days 3-4; P3-P4) for keeping them immobile for a long period. In our first experiment we analysed the behaviour of P3-P4 mouse pups for 70 min after intraperitoneal administration of low (37.5/3.75 mg/kg) or high (50/5) doses of a ketamine/xylazine anaesthetic mixture, both in the low range as compared with dosages employed in adults...
March 18, 2024: Laboratory Animals
https://read.qxmd.com/read/38494900/adenomyosis-among-patients-undergoing-postpartum-hysterectomy-for-uncontrollable-uterine-bleeding-a%C3%A2-multicenter-observational-retrospective-cohort-study-on-histologically-based-prevalence-and-clinical-characteristics
#25
JOURNAL ARTICLE
Matteo Giorgi, Diego Raimondo, Martina Pacifici, Ludovica Bartiromo, Massimo Candiani, Francesco Fedele, Alessandra Pizzo, Herbert Valensise, Renato Seracchioli, Antonio Raffone, Francesco Giuseppe Martire, Gabriele Centini, Errico Zupi, Lucia Lazzeri
OBJECTIVE: To assess the prevalence of adenomyosis at pathologic examination, and its association with obstetric complications, peripartum maternal clinical characteristics and neonatal birth weight in patients undergoing postpartum hysterectomy due to postpartum hemorrhage (PPH). METHODS: A multicenter, observational, retrospective, cohort study was carried out including all women who underwent postpartum hysterectomy due to PPH at gestational week 23+0 or later, between January 2010 and May 2023...
March 18, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38494527/alpha-pinene-ameliorate-behavioral-deficit-induced-by-early-postnatal-hypoxia-in-the-rat-study-the-inflammatory-mechanism
#26
JOURNAL ARTICLE
Sharareh Bakhtazad, Zohreh Ghotbeddin, Mohammad Reza Tabandeh, Kaveh Rahimi
Neonatal hypoxia has a negative impact on the developing brain during the sensitive period. Inflammation plays a key role in the physiological response to hypoxic stress. Considering the anti-inflammatory properties of alpha-pinene, which has received a lot of attention in recent years, in this research we focused on the impact of alpha-pinene on the behavioral responses and proinflammatory factors in rats subjected to the neonatal hypoxia. This study involved Wistar rats (7-day-old) that were divided into six experimental groups, including a control group, groups receiving different doses of alpha-pinene (5 and 10 mg/kg), a hypoxia group receiving 7% O2 and 93% N2 , 90 min duration for 7 days, and groups receiving alpha-pinene 30 min before hypoxia...
March 17, 2024: Scientific Reports
https://read.qxmd.com/read/38494404/use-of-a-peanut-ball-positioning-and-pelvic-mobility-in-parturient-women-shortens-labour-and-improves-maternal-satisfaction-with-childbirth-a-randomised-trial
#27
JOURNAL ARTICLE
Chalana Duarte de Sena Fraga, Rodrigo Cappato de Araújo, Layane de Sá, Ana Julia Santos Bertoldo, Ana Carolina Rodarti Pitangui
QUESTION: What is the effect of a protocol targeted at the various stages of labour - with a peanut ball, positioning and pelvic mobility - on the duration of labour, pain severity, fatigue, maternal outcomes, neonatal outcomes and satisfaction in parturients without analgesia? DESIGN: A randomised trial with concealed allocation, blinding of assessors and intention-to-treat analysis. PARTICIPANTS: One hundred women in active labour. INTERVENTION: The experimental group received the protocol targeted at the various stages of labour, with a peanut ball, positioning and pelvic mobility, whilst the control group received usual care...
March 16, 2024: Journal of Physiotherapy
https://read.qxmd.com/read/38494283/myasthenia-gravis-pathophysiology-diagnosis-and-treatment
#28
JOURNAL ARTICLE
Martijn R Tannemaat, Maartje G Huijbers, Jan J G M Verschuuren
Myasthenia gravis (MG) is an autoimmune disease characterized by dysfunction of the neuromuscular junction resulting in skeletal muscle weakness. It is equally prevalent in males and females, but debuts at a younger age in females and at an older age in males. Ptosis, diplopia, facial bulbar weakness, and limb weakness are the most common symptoms. MG can be classified based on the presence of serum autoantibodies. Acetylcholine receptor (AChR) antibodies are found in 80%-85% of patients, muscle-specific kinase (MuSK) antibodies in 5%-8%, and <1% may have low-density lipoprotein receptor-related protein 4 (Lrp4) antibodies...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38494180/congenital-bilio-bronchial-fistula-in-an-adult-a-review-of-literature-and-video-demonstration-of-laparoscopic-fistula-tract-excision
#29
REVIEW
Chandrasekar Murugesan, Muniza Bai, Biju Pottakkat, Dharm Prakash Dwivedi, Hemachandren Munuswamy, Pazhanivel Mohan
This article presents a review of the literature on congenital bilio-bronchial fistula (BBF), a rare anomaly characterized by abnormal communication between the bile duct and respiratory tract. Congenital BBF often presents with bilioptysis in early neonates and infants; however, patients with no overt symptoms may occasionally present in adulthood. Our literature search in Medline from 1850 to 2023 revealed 42 reported cases of congenital BBF, primarily managed with thoracotomy and excision of the fistula tract...
March 15, 2024: Journal of minimally invasive surgery
https://read.qxmd.com/read/38494134/multidimensional-assessment-of-adverse-events-of-bupropion-a-large-scale-data-analysis-from-the-faers-database
#30
JOURNAL ARTICLE
Rongrong Lu, Ying Jiang, Zhiqiang Du, Qin Zhou, Yuan Shen, Haohao Zhu
OBJECTIVE: Bupropion, a monocyclic antidepressant, aids in smoking cessation, treats major depression, and prevents severe depression in seasonal affective disorder patients. Yet, its adverse reactions remain insufficiently studied. METHODS: All data from the raw data packages for 78 quarters from the 1st quarter of 2004 to the 2nd quarter of 2023 were extracted from the FDA Adverse Event Reporting System (FAERS) database and imported into the SAS9.4 software for data cleaning and analysis...
March 15, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38494123/resveratrol-evokes-neuroprotective-effects-and-improves-foot-stance-following-kainate-induced-excitotoxic-damage-to-the-mouse-spinal-cord
#31
JOURNAL ARTICLE
Benjamín Zylberberg, Martina Poodts, Julieta Roncoroni, M Florencia Coronel, Graciela L Mazzone
Excitotoxicity, characterized by over-activation of glutamate receptors, is a major contributor to spinal cord injury (SCI) pathophysiology, resulting in neuronal death and loss of locomotor function. In our previous in vitro studies, we showed that excitotoxicity induced by the glutamate analogue kainate (KA) leads to a significant reduction in the number of neurons, providing a model for SCI. Our current objective was to assess the neuroprotective role of resveratrol (RESV), a natural polyphenol, following KA-induced SCI...
March 15, 2024: Neuropharmacology
https://read.qxmd.com/read/38494087/readmission-after-nicu-discharge-the-importance-of-social-drivers-of-health
#32
JOURNAL ARTICLE
John Feister, Peiyi Kan, Henry C Lee, Lee Sanders
OBJECTIVE: To determine associations between sociodemographic and medical factors and odds of readmission after discharge from the neonatal intensive care unit (NICU) for infants with very low birth weight (VLBW, <1500g). STUDY DESIGN: Cohort study using linked data from the California Perinatal Quality Care Collaborative, California Vital Statistics, and the Child Opportunity Index 2.0 (COI). Infants with VLBW born from 2009 through 2018 in California were considered...
March 15, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38494035/three-dimensional-imaging-of-the-enteric-nervous-system-in-human-pediatric-colon-reveals-new-features-of-hirschsprung-disease
#33
JOURNAL ARTICLE
Joshua D Eisenberg, Rebecca P Bradley, Kahleb D Graham, Rachel H Ceron, Amanda M Lemke, Benjamin J Wilkins, Ali Naji, Robert O Heuckeroth
BACKGROUND AND AIMS: Hirschsprung disease is defined by the absence of enteric nervous system (ENS) from distal bowel. Primary treatment is "pull-through" surgery to remove bowel that lacks ENS with re-anastomosis of "normal" bowel near the anal verge. Problems after pull-through are common and some may be due to retained hypoganglionic bowel (i.e., low ENS density). Testing this hypothesis has been difficult because counting enteric neurons in tissue sections is unreliable even for experts...
March 15, 2024: Gastroenterology
https://read.qxmd.com/read/38493982/neuroligin1-in-excitatory-synapses-contributes-to-long-term-cognitive-impairments-after-repeated-neonatal-sevoflurane-exposures
#34
JOURNAL ARTICLE
Hui Zhang, Yingqiao Niu, Peng Yuan, Wenbo Liu, Wei Zhu, Jie Sun
BACKGROUND: Repeated sevoflurane exposures in neonatal rats may lead to neuronal apoptosis affecting long-term cognitive function, the mechanism is unknown. Neuroligin1 (NL1) is essential for normal excitatory transmission and long-term synaptic plasticity in the hippocampus of intact animals. Herein, we explore the role of NL1 in hippocampal excitatory synapses on long-term cognitive impairments induced by repeated sevoflurane exposures in neonatal rats. METHODS: From postnatal day six (P6) to P8, neonatal rats were exposed to 30% oxygen or 3% sevoflurane +30% oxygen for 2 h daily...
March 15, 2024: Experimental Neurology
https://read.qxmd.com/read/38493976/a-21-day-safety-evaluation-of-biotechnologically-produced-3-fucosyllactose-3-fl-in-neonatal-farm-piglets-to-support-use-in-infant-formulas
#35
JOURNAL ARTICLE
Jeffrey Pitt, Jennifer Bond, Jason Roper, Paul Tenning, Ratna Mukherjea, Kara Evans, Markku T Saarinen, Heli Anglenius, Johanna Hirvonen, Oliver Hasselwander, Angela Lim
3-Fucosyllactose (3-FL) is one of the most abundant fucosylated oligosaccharides in human breast milk and is an approved infant formula ingredient world-wide. 3-FL functions as a prebiotic to promote early microbial colonization of the gut, increase pathogen resistance and modulate immune responses. To investigate safety and potential gut microbiota effects, 3-FL was fed for 21-days to farm piglets beginning on Postnatal Day (PND) 2. Fructooligosaccharide (FOS), an approved infant formula ingredient, was used as a reference control...
March 15, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38493795/global-regional-and-national-burden-of-disorders-affecting-the-nervous-system-1990-2021-a-systematic-analysis-for-the-global-burden-of-disease-study-2021
#36
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage...
March 5, 2024: Lancet Neurology
https://read.qxmd.com/read/38493709/enterovirus-and-parechovirus-meningoencephalitis-in-infants-a-ten-year-prospective-observational-study-in-a-neonatal-intensive-care-unit
#37
JOURNAL ARTICLE
Carlo Pietrasanta, Andrea Ronchi, Laura Bassi, Agnese De Carli, Luca Caschera, Francesco Maria Lo Russo, Beatrice Letizia Crippa, Silvia Pisoni, Riccardo Crimi, Giacomo Artieri, Laura Pellegrinelli, Robertino Dilena, Giorgio Conte, Fabio Mosca, Monica Fumagalli, Lorenza Pugni
BACKGROUND: Non-polio enteroviruses (EV) and human parechoviruses (HPeV) are known etiological agents of meningoencephalitis in neonates. However, reports of neuroradiological findings and neurodevelopmental outcomes in this population are scarce. OBJECTIVES: to describe clinical characteristics, neuroradiological findings and, in a subset of patients, neurodevelopmental outcomes in a cohort of infants with EV or HPeV meningoencephalitis within 60 days of life. STUDY DESIGN: clinical/laboratory data, neuroradiological findings (cranial ultrasound, cUS, brain magnetic resonance imaging, MRI), and neurodevelopmental outcomes assessed by Ages and Stages Questionnaires - third edition were prospectively collected...
March 5, 2024: Journal of Clinical Virology
https://read.qxmd.com/read/38493548/role-of-benzophenone-3-additive-in-the-effect-of-polyethylene-microplastics-on-daphnia-magna-population-dynamics
#38
JOURNAL ARTICLE
Changhae Kim, Gabriela Kalčíková, Jinho Jung
The adverse effects of microplastics (MPs) on Daphnia magna have been extensively studied; however, their population-level effects are relatively unknown. This study investigated the effect of polyethylene MP fragments (33.90 ± 17.44 μm) and benzophenone-3 (BP-3), which is a widely used plastic additive (2.91 ± 0.02% w/w), on D. magna population dynamics in a 34-day microcosm experiment. In the growth phase, neither MP nor MP/BP-3 fragments changed the population size of D. magna compared with the control...
March 14, 2024: Aquatic Toxicology
https://read.qxmd.com/read/38493519/prepregnancy-dieting-and-obstetrical-and-neonatal-outcomes-findings-from-a-national-surveillance-project-in-the-united-states
#39
JOURNAL ARTICLE
Yang Yu, Qianheng Ma, Susan W Groth
PROBLEM AND BACKGROUND: Women with overweight or obesity are recommended to lose weight before pregnancy. Dieting is one of the most used weight control strategies. However, the health implications of dieting before pregnancy remain unclear. AIM: To evaluate the associations of dieting during the year before pregnancy with obstetrical and neonatal outcomes, including gestational weight gain (GWG), gestational diabetes, low birthweight, macrosomia, small-for-gestational-age infants (SGA), large-for-gestational-age infants (LGA), and preterm birth...
March 7, 2024: Midwifery
https://read.qxmd.com/read/38493431/evaluation-of-the-protective-and-therapeutic-effects-of-extra-virgin-olive-oil-rich-in-phenol-in-experimental-model-of-neonatal-necrotizing-enterocolitis-by-clinical-disease-score-%C3%A4-nflammation-apoptosis-and-oxidative-stress-markers
#40
JOURNAL ARTICLE
Mustafa Tuşat, Recep Eroz, Ferhan Bölükbaş, Erkan Özkan, Hüseyin Erdal
BACKGROUND AND AIM: Necrotizing Enterocolitis (NEC) is an inflammation-associated ischemic necrosis of the intestine. To investigate the effects of extra virgin olive oil (EVOO) on inflammation, oxidative stress, apoptosis, and histological changes in NEC-induced newborn rats. MATERIALS AND METHODS: 24 rats were randomly divided into three groups: control, NEC and NEC + EVOO. NEC induction was performed using hypoxia-hyperoxia, formula feeding, and cold stress...
March 17, 2024: Pediatric Surgery International
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