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Optic nerve sheath

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https://www.readbyqxmd.com/read/28304207/dural-venous-sinus-stenting-for-medically-and-surgically-refractory-idiopathic-intracranial-hypertension
#1
Sudhakar R Satti, Lakshmi Leishangthem, Alejandro Spiotta, M Imran Chaudry
Background Idiopathic intracranial hypertension (IIH) is a syndrome defined by elevated intracranial hypertension without radiographic evidence of a mass lesion in the brain. Dural venous sinus stenosis has been increasingly recognized as a treatable cause, and dural venous sinus stenting (DVSS) is increasingly performed. Methods A 5 year single-center retrospective analysis of consecutive patients undergoing DVSS for medically refractory IIH. Results There were 43 patients with a mean imaging follow-up of 6...
April 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28284189/changes-in-intraocular-pressure-and-optic-nerve-sheath-diameter-in-patients-undergoing-robotic-assisted-laparoscopic-prostatectomy-in-steep-45%C3%A2-trendelenburg-position
#2
Sebastian Blecha, Marion Harth, Felix Schlachetzki, Florian Zeman, Christiane Blecha, Pierre Flora, Maximilian Burger, Stefan Denzinger, Bernhard M Graf, Horst Helbig, Michael T Pawlik
BACKGROUND: To evaluate changes in intraocular pressure (IOP) and intracerebral pressure (ICP) reflected by the optic nerve sheath diameter (ONSD) in patients undergoing robotic-assisted laparoscopic prostatectomy (RALP) in permanent 45° steep Trendelenburg position (STP). METHODS: Fifty-one patients undergoing RALP under a standardised anaesthesia. IOP was perioperatively measured in awake patients (T0) and IOP and ONSD 20 min after induction of anaesthesia (T1), after insufflation of the abdomen in supine position (T2), after 30 min in STP (T3), when controlling Santorini's plexus in STP (T4) and before awakening while supine (T5)...
March 11, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28255904/endovascular-treatment-of-idiopathic-intracranial-hypertension-retrospective-analysis-of-immediate-and-long-term-results-in-51-patients
#3
M Aguilar-Pérez, R Martinez-Moreno, W Kurre, C Wendl, H Bäzner, O Ganslandt, R Unsöld, H Henkes
PURPOSE: Idiopathic intracranial hypertension (IIH) is a disorder of increased intracranial pressure in the absence of any known causative factor. Sinus stenosis is common in these patients. Stenting of stenotic dural sinuses has gained popularity as a treatment option, since these stenoses may contribute to an obstruction of the venous return, and, thereby may contribute to IIH via an increase in venous sinus pressure. We evaluated the safety and efficacy of endovascular treatment in IIH with venous sinus stenosis...
March 2, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28243026/initial-pattern-of-optic-nerve-enhancement-in-korean-patients-with-unilateral-optic-neuritis
#4
COMPARATIVE STUDY
Dae Yong Son, Kyung-Ah Park, Su Sie Seok, Ju-Yeun Lee, Sei Yeul Oh
PURPOSE: The purpose of this study was to demonstrate whether the pattern of optic nerve enhancement in magnetic resonance imaging (MRI) can help to differentiate between idiopathic optic neuritis (ON), neuromyelitis optica (NMO), and multiple sclerosis (MS) in unilateral ON. METHODS: An MRI of the brain and orbits was obtained in patients with acute unilateral ON. Patients with ON were divided into three groups: NMO, MS, and idiopathic ON. The length and location of the abnormal optic nerve enhancement were compared for ON eyes with and without NMO or MS...
February 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28242992/somatostatin-receptor-spect-ct-using-99m-tc-labeled-hynic-toc-aids-in-diagnosis-of-primary-optic-nerve-sheath-meningioma
#5
Piyush Chandra, Nilendu Purandare, Sneha Shah, Archi Agrawal, Venkatesh Rangarajan
Primary optic nerve sheath meningiomas (ONSM) are rare, benign and slow growing tumor involving the intra-orbital/intra-canalicular segment of the optic nerve. Untreated, they can potentially lead to visual deterioration. Magnetic resonance (MR) is the gold standard imaging modality for diagnosing the entity. Often, a clinical dilemma exists to narrow the differential diagnosis of an enhancing intra-orbital mass on MR. Molecular imaging provides a high degree of precision in diagnosing meningioma in view of relatively high levels of somatostatin receptor expression by these tumors...
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28237322/effect-of-chronic-administration-of-sildenafil-citrate-viagra-on-the-histology-of-the-retina-and-optic-nerve-of-adult-male-rat
#6
Sohair A Eltony, Sally Y Abdelhameed
BACKGROUND: Abnormal vision has been reported by 3% of patients treated with sildenafil citrate (Viagra). Although many men use Viagra for an extended period for treatment of erectile dysfunction, the implications of the long term-daily use of it on the retina and optic nerve are unclear. AIM OF THE WORK: To investigate the effect of chronic daily use of sildenafil citrate in a dose equivalent to men preferred therapeutic dose on the histology of the retina and optic nerve of adult male rat...
February 5, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28230061/neurofibromatosis-type-1
#7
REVIEW
David H Gutmann, Rosalie E Ferner, Robert H Listernick, Bruce R Korf, Pamela L Wolters, Kimberly J Johnson
Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis type 1 develop pigmentary lesions (café-au-lait macules, skinfold freckling and Lisch nodules) and dermal neurofibromas. Some individuals develop skeletal abnormalities (scoliosis, tibial pseudarthrosis and orbital dysplasia), brain tumours (optic pathway gliomas and glioblastoma), peripheral nerve tumours (spinal neurofibromas, plexiform neurofibromas and malignant peripheral nerve sheath tumours), learning disabilities, attention deficits, and social and behavioural problems, which can negatively affect quality of life...
February 23, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28188622/the-optic-nerve-superior-colliculus-visual-thalamus-and-primary-visual-cortex-of-the-northern-elephant-seal-mirounga-angustirostris-and-california-sea-lion-zalophus-californianus
#8
Emily C Turner, Eva K Sawyer, Jon H Kaas
The northern elephant seal (Mirounga angustirostris) and California sea lion (Zalophus californianus) are members of a diverse clade of carnivorous mammals known as pinnipeds. Pinnipeds are notable for their large, ape-sized brains, yet little is known about their central nervous system. Both the northern elephant seal and California sea lion spend most of their lives at sea, but each also spends time on land to breed and give birth. These unique coastal niches may be reflected in specific evolutionary adaptations to their sensory systems...
February 11, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28181232/does-iih-alter-brain-microstructures-a-dti-based-approach
#9
Christoph Schmidt, Edzard Wiener, Lutz Lüdemann, Hagen Kunte, Katharina Maria Kreutz, Nils Becker, Lutz Harms, Randolf Klingebiel, Jan Hoffmann
INTRODUCTION: To investigate the correlation of microstructural parameters with CSF pressure and macroscopic changes assessed by diffusion tensor imaging (DTI) in patients with idiopathic intracranial hypertension (IIH). METHODS: Twenty-three patients with IIH as well as age-, sex-, and body mass index (BMI)-matched controls underwent high resolution MR imaging of the optic nerve sheaths (ONS), pituitary gland, and ventricles. For DTI data a voxelwise permutation analysis was performed for the whole brain and ROI analysis was performed for the optic nerve and optic radiation...
February 9, 2017: Headache
https://www.readbyqxmd.com/read/28177116/effects-of-acute-controlled-changes-in-end-tidal-carbon-dioxide-on-the-diameter-of-the-optic-nerve-sheath-a-transorbital-ultrasonographic-study-in-healthy-volunteers
#10
M Dinsmore, J S Han, J A Fisher, V W S Chan, L Venkatraghavan
Transorbital ultrasonographic measurement of the diameter of the optic nerve sheath is a non-invasive, bed-side examination for detecting raised intracranial pressure. However, the ability of the optic nerve sheath diameter to predict acute changes in intracranial pressures remains unknown. The aim of this study was to examine the dynamic changes of the optic nerve sheath diameter in response to mild fluctuations in cerebral blood volume induced by changes in end-tidal carbon dioxide. We studied 11 healthy volunteers...
February 8, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28169341/noninvasive-and-quantitative-intracranial-pressure-estimation-using-ultrasonographic-measurement-of-optic-nerve-sheath-diameter
#11
Li-Juan Wang, Yan Yao, Liang-Shu Feng, Yu-Zhi Wang, Nan-Nan Zheng, Jia-Chun Feng, Ying-Qi Xing
We aimed to quantitatively assess intracranial pressure (ICP) using optic nerve sheath diameter (ONSD) measurements. We recruited 316 neurology patients in whom ultrasonographic ONSD was measured before lumbar puncture. They were randomly divided into a modeling and a test group at a ratio of 7:3. In the modeling group, we conducted univariate and multivariate analyses to assess associations between ICP and ONSD, age, sex, BMI, mean arterial blood pressure, diastolic blood pressure. We derived the mathematical function "Xing &Wang" from the modelling group to predict ICP and evaluated the function in the test group...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28159969/targeted-metabolomics-reveals-early-dominant-optic-atrophy-signature-in-optic-nerves-of-opa1delttag-mice
#12
Juan Manuel Chao de la Barca, Gilles Simard, Emmanuelle Sarzi, Tanguy Chaumette, Guillaume Rousseau, Stéphanie Chupin, Cédric Gadras, Lydie Tessier, Marc Ferré, Arnaud Chevrollier, Valérie Desquiret-Dumas, Naïg Gueguen, Stéphanie Leruez, Christophe Verny, Dan Miléa, Dominique Bonneau, Patrizia Amati-Bonneau, Vincent Procaccio, Christian Hamel, Guy Lenaers, Pascal Reynier, Delphine Prunier-Mirebeau
Purpose: Dominant optic atrophy (MIM No. 165500) is a blinding condition related to mutations in OPA1, a gene encoding a large GTPase involved in mitochondrial inner membrane dynamics. Although several mouse models mimicking the disease have been developed, the pathophysiological mechanisms responsible for retinal ganglion cell degeneration remain poorly understood. Methods: Using a targeted metabolomic approach, we measured the concentrations of 188 metabolites in nine tissues, that is, brain, three types of skeletal muscle, heart, liver, retina, optic nerve, and plasma in symptomatic 11-month-old Opa1delTTAG/+ mice...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28156180/diagnosis-of-optic-nerve-sheath-meningioma-during-optic-nerve-sheath-decompression
#13
Austin R Meeker, Melissa W Ko, Bryant P Carruth, Kenneth B Strumpf, Thomas A Bersani
Optic nerve sheath meningioma (ONSM) is typically diagnosed based on clinical suspicion and imaging characteristics and is most often treated with radiation. Historically, biopsy, optic nerve sheath decompression, and debulking surgeries have been avoided for fear of optic nerve vascular disruption and tumor spread into the orbit. This is a case of a 48-year-old man who presented with unilateral optic disc edema, declining visual acuity, and a visual field defect. Despite an initial improvement with acetazolamide, his vision subsequently worsened...
February 2017: Orbit
https://www.readbyqxmd.com/read/28146012/identification-of-optic-nerve-swelling-using-point-of-care-ocular-ultrasound-in-children
#14
Ronald F Marchese, Rakesh D Mistry, Gil Binenbaum, Grant T Liu, Richard J Scarfone, Ashley L Woodford, Aaron E Chen
OBJECTIVE: The aim of this study was to determine the feasibility and accuracy of point-of-care (POC) ocular ultrasound (US) when performed by a pediatric emergency medicine (PEM) physician to detect optic nerve abnormalities concerning for swelling, as compared with the fundus examination performed by an ophthalmologist. METHODS: This was a single-center, prospective cohort pilot study of children aged 12 months to 18 years who required optic disc evaluation by an ophthalmologist...
January 31, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28144922/current-concepts-and-strategies-in-the-diagnosis-and-management-of-idiopathic-intracranial-hypertension-in-adults
#15
REVIEW
Jane W Chan
Since obesity has become an epidemic in industrialized nations, idiopathic intracranial hypertension (IIH) is now a more common neuro-ophthalmic disorder that causes visual loss and headaches. This review highlights the new diagnostic criteria for IIH and the new insights into the pathophysiologic mechanisms of IIH. Key diagnostic and monitoring techniques for papilledema include not only neuroimaging and the measurement of cerebrospinal fluid (CSF) pressure, but also perimetry, optical coherence tomography, and ocular sonography...
January 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28135565/dissecting-clinical-heterogeneity-in-neurofibromatosis-type-1
#16
Courtney L Monroe, Sonika Dahiya, David H Gutmann
Neurofibromatosis type 1 (NF1) is a common neurogenetic disorder in which affected children and adults are predisposed to the development of benign and malignant nervous system tumors. Caused by a germline mutation in the NF1 tumor suppressor gene, individuals with NF1 are prone to optic gliomas, malignant gliomas, neurofibromas, and malignant peripheral nerve sheath tumors, as well as behavioral, cognitive, motor, bone, cardiac, and pigmentary abnormalities. Although NF1 is a classic monogenic syndrome, the clinical features of the disorder and their impact on patient morbidity are variable, even within individuals who bear the same germline NF1 gene mutation...
January 24, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/28131870/waiting-to-deliver-a-final-diagnosis
#17
Ali Mokhtarzadeh, Amanda Maltry, Collin McClelland
We report a patient with left eye positional transient visual obscurations, diplopia, a left afferent pupillary defect, and optic disk edema-all occurring during pregnancy. Noncontrast magnetic resonance imaging revealed an orbital mass encasing the optic nerve and extending through the superior orbital fissure into the cavernous sinus. An magnetic resonance imaging with gadolinium after parturition and strongly positive somatostatin receptor scintigraphy suggested the diagnosis of meningioma. Biopsy confirmed the diagnosis, and she was treated with CyberKnife stereotactic radiosurgery...
January 25, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28130923/node-of-ranvier-length-as-a-potential-regulator-of-myelinated-axon-conduction-speed
#18
I Lorena Arancibia-Cárcamo, Marc C Ford, Lee Cossell, Kinji Ishida, Koujiro Tohyama, David Attwell
Myelination speeds conduction of the nerve impulse, enhancing cognitive power. Changes of white matter structure contribute to learning, and are often assumed to reflect an altered number of myelin wraps. We now show that, in rat optic nerve and cerebral cortical axons, the node of Ranvier length varies over a 4.4-fold and 8.7-fold range respectively and that variation of the node length is much less along axons than between axons. Modelling predicts that these node length differences will alter conduction speed by ~20%, similar to the changes produced by altering the number of myelin wraps or the internode length...
January 28, 2017: ELife
https://www.readbyqxmd.com/read/28118848/the-association-of-findings-on-brain-computed-tomography-with-neurologic-outcomes-following-extracorporeal-cardiopulmonary-resuscitation
#19
Jeong-Am Ryu, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Gee Young Suh, Taek Kyu Park, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Hyeon-Cheol Gwon, Seung-Hyuk Choi, Jeong Hoon Yang
BACKGROUND: Limited data are available on imaging predictors of neurological outcomes after extracorporeal cardiopulmonary resuscitation (ECPR). We investigated the association of initial brain computed tomography (CT) findings with neurological outcomes following ECPR. METHODS: Between February 2005 and December 2015, a total of 42 patients who underwent brain CT scans within 48 h after ECPR were analyzed. Loss of the boundary between gray matter and white matter (LOB) or cortical sulcal effacement (SE), gray-to-white matter ratio (GWR), and optic nerve sheath diameter (ONSD) were measured on initial brain CT...
January 25, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28112137/orbital-melanoma-with-calcification-a-diagnostic-dilemma
#20
Sukhdeep Bains, Usha Kim, R Shanti
Primary orbital melanoma is rare and has varied initial presentation. A 28-year-old female presented with proptosis and decreased vision in the left eye. Computed tomography scan showed an orbital mass with contrast enhancement and calcification around the optic nerve leading to a diagnosis of meningioma. The patient chose to be on observation. Loss of vision with an increase in proptosis was seen at 6 months follow-up. On surgical exploration, a well-defined pigmented mass was seen encasing the optic nerve...
December 2016: Indian Journal of Ophthalmology
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