André Schrauder, Alfred Reiter, Helmut Gadner, Dietrich Niethammer, Thomas Klingebiel, Bernhard Kremens, Christina Peters, Wolfram Ebell, Martin Zimmermann, Felix Niggli, Wolf-Dieter Ludwig, Hansjörg Riehm, Karl Welte, Martin Schrappe
PURPOSE: The role of hematopoietic stem-cell transplantation (SCT) in first complete remission (CR1) for children with very high-risk (VHR) acute lymphoblastic leukemia (ALL) is still under critical discussion. PATIENTS AND METHODS: In the ALL-Berlin-Frankfurt-Münster (BFM) 90 and ALL-BFM 95 trials, 387 patients were eligible for SCT if there was a matched sibling donor (MSD). T-cell ALL (T-ALL) patients with poor in vivo response to initial treatment represented the largest homogeneous subgroup within VHR patients...
December 20, 2006: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology