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https://www.readbyqxmd.com/read/28635665/towards-a-uniform-metrological-assessment-of-grating-based-optical-fiber-sensors-from-refractometers-to-biosensors
#1
REVIEW
Francesco Chiavaioli, Carlos A J Gouveia, Pedro A S Jorge, Francesco Baldini
A metrological assessment of grating-based optical fiber sensors is proposed with the aim of providing an objective evaluation of the performance of this sensor category. Attention was focused on the most common parameters, used to describe the performance of both optical refractometers and biosensors, which encompassed sensitivity, with a distinction between volume or bulk sensitivity and surface sensitivity, resolution, response time, limit of detection, specificity (or selectivity), reusability (or regenerability) and some other parameters of generic interest, such as measurement uncertainty, accuracy, precision, stability, drift, repeatability and reproducibility...
June 21, 2017: Biosensors
https://www.readbyqxmd.com/read/28632445/critique-and-contribute-a-practice-based-framework-for-improving-critical-data-studies-and-data-science
#2
Gina Neff, Anissa Tanweer, Brittany Fiore-Gartland, Laura Osburn
What would data science look like if its key critics were engaged to help improve it, and how might critiques of data science improve with an approach that considers the day-to-day practices of data science? This article argues for scholars to bridge the conversations that seek to critique data science and those that seek to advance data science practice to identify and create the social and organizational arrangements necessary for a more ethical data science. We summarize four critiques that are commonly made in critical data studies: data are inherently interpretive, data are inextricable from context, data are mediated through the sociomaterial arrangements that produce them, and data serve as a medium for the negotiation and communication of values...
June 2017: Big Data
https://www.readbyqxmd.com/read/28560701/nano-calorimetry-based-point-of-care-biosensor-for-metabolic-disease-management
#3
Evan Kazura, Brad R Lubbers, Elliott Dawson, John A Phillips, Franz Baudenbacher
Point of care (POC) diagnostics represents one of the fastest growing health care technology segments. Developments in microfabrication have led to the development of highly-sensitive nanocalorimeters ideal for directly measuring heat generated in POC biosensors. Here we present a novel nano-calorimeter-based biosensor design with differential sensing to eliminate common mode noise and capillary microfluidic channels for sample delivery to the thermoelectric sensor. The calorimeter has a resolution of 1.4 ± 0...
September 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28552543/translating-cough-mechanisms-into-better-cough-suppressants
#4
REVIEW
Jennifer A Keller, Alice E McGovern, Stuart B Mazzone
Chronic cough is a significant problem and in many patients' cough remains refractive to both disease specific therapies and current cough suppressing medicines, creating a need for improved anti-tussive therapies. Most patients with chronic cough also display heightened sensitivity such that they experience a persistent sense of the need to cough and often innocuous stimuli can trigger their coughing. This hypersensitivity underpins the newly described concept of Cough Hypersensitivity Syndrome (CHS), a term that encapsulates the notion of common underlying mechanisms producing neuronal activation, sensitization and/or dysfunction, which are at the core of excessive coughing...
May 25, 2017: Chest
https://www.readbyqxmd.com/read/28550813/a-reliable-sewage-quality-abnormal-event-monitoring-system
#5
Tianling Li, Melissa Winnel, Hao Lin, Jared Panther, Chang Liu, Roger O'Halloran, Kewen Wang, Taicheng An, Po Keung Wong, Shanqing Zhang, Huijun Zhao
With closing water loop through purified recycled water, wastewater becomes a part of source water, requiring reliable wastewater quality monitoring system (WQMS) to manage wastewater source and mitigate potential health risks. However, the development of reliable WQMS is fatally constrained by severe contamination and biofouling of sensors due to the hostile analytical environment of wastewaters, especially raw sewages, that challenges the limit of existing sensing technologies. In this work, we report a technological solution to enable the development of WQMS for real-time abnormal event detection with high reliability and practicality...
May 20, 2017: Water Research
https://www.readbyqxmd.com/read/28528123/quantitative-biology-of-hydrogen-peroxide-signaling
#6
REVIEW
Fernando Antunes, Paula Matos Brito
Hydrogen peroxide (H2O2) controls signaling pathways in cells by oxidative modulation of the activity of redox sensitive proteins denominated redox switches. Here, quantitative biology concepts are applied to review how H2O2 fulfills a key role in information transmission. Equations described lay the foundation of H2O2 signaling, give new insights on H2O2 signaling mechanisms, and help to learn new information from common redox signaling experiments. A key characteristic of H2O2 signaling is that the ratio between reduction and oxidation of redox switches determines the range of H2O2 concentrations to which they respond...
May 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/28492215/public-health-achievements-and-challenges-symposium-of-the-university-of-mostar-faculty-of-health-studies
#7
Jelena Ravlija, Ivan Vasilj, Dragan Babic, Inga Marijanovic
Public health is an important area of health care that reflects the readiness of the state and society to provide the welfare of all citizens through the promotion of health and the preservation of a healthy environment - factors that directly affect the health of the population. The field of public health is very broad and its concept is changing over time, being defined in a narrower and wider sense. In short, public health is a science and practice that aims at ensuring the conditions in which people can preserve and improve their health and prevent health damage...
May 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28483808/setting-boundaries-public-views-on-limiting-patient-and-physician-autonomy-in-health-care-decisions
#8
Maureen Maurer, Rikki Mangrum, Kristin L Carman, Marjorie Ginsburg, Marthe R Gold, Shoshanna Sofaer, Ela Pathak-Sen, Jennifer Richmond, Joanna Siegel
We obtained and qualitatively analyzed input from more than nine hundred citizens during seventy-six public deliberation sessions about patient and physician autonomy in decision making, setting health care boundaries, and the tensions among competing social values. Generally, participants resisted interference with the patient-physician relationship and believed strongly in the freedom of patient and physician to control individual medical decisions. However, during deliberation participants identified two situations where boundaries and regulations in health care were more acceptable: protecting people from harm and allocating limited resources...
May 8, 2017: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/28401811/hooked-on-a-feeling-exploring-desires-and-solutions-in-infertility-accounts-given-by-women-with-atypical-sex-development
#9
Lisa Guntram
Sociocultural meanings accorded to infertility, and rapid developments in assisted reproductive technologies, have long been central concerns in feminist and social scientific research. However, knowledge is scarce concerning how individuals make sense of infertility when it is disclosed in adolescence, for example as the result of an 'atypical' sex development, rather than as a result of failed conception. This article examines how understandings of desires, kinship and 'solutions' take shape and are negotiated in the accounts women give of infertility resulting from 'atypical' sex development...
January 1, 2017: Health (London)
https://www.readbyqxmd.com/read/28294110/proposal-for-dark-exciton-based-chemical-sensors
#10
Maja Feierabend, Gunnar Berghäuser, Andreas Knorr, Ermin Malic
The rapidly increasing use of sensors throughout different research disciplines and the demand for more efficient devices with less power consumption depends critically on the emergence of new sensor materials and novel sensor concepts. Atomically thin transition metal dichalcogenides have a huge potential for sensor development within a wide range of applications. Their optimal surface-to-volume ratio combined with strong light-matter interaction results in a high sensitivity to changes in their surroundings...
March 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28229854/-how-to-manage-with-rigour-but-flexibility-an-orthodontic-practice
#11
Edmond Binhas, Corinne Binhas
INTRODUCTION: An orthodontic office owner must understand the context and then combine logic, emotion, intuition and common sense. The productivity approach is no longer acceptable. It is necessary to combine rigour, flexibility and pragmatism. DISCUSSION: The obsessive perfectionism is ineffective. In fact, there are four ways to demonstrate a flexible determination: persevere when appropriate, win the support of your entourage, back on some decisions, appeal to the collective will...
March 2017: L' Orthodontie Française
https://www.readbyqxmd.com/read/28194453/a-paper-based-platform-for-detection-of-viral-rna
#12
Daohong Zhang, David Broyles, Eric A Hunt, Emre Dikici, Sylvia Daunert, Sapna K Deo
Viral detection presents a host of challenges for even the most sensitive analytical techniques, and the complexity of common detection platforms typically preclude portability. With these considerations in mind, we designed a paper microzone plate-based virus detection system for the detection of viral genetic material that can be performed with simple instruments. The sensing system can detect viral cDNA reverse-transcribed from total RNA extraction by utilizing a biotinylated capture probe and an Alexa Fluor® 647-labeled reporter probe...
February 27, 2017: Analyst
https://www.readbyqxmd.com/read/28157992/generalized-high-spectral-resolution-lidar-technique-with-a-multimode-laser-for-aerosol-remote-sensing
#13
Zhongtao Cheng, Dong Liu, Yupeng Zhang, Chong Liu, Jian Bai, Dan Wang, Nanchao Wang, Yudi Zhou, Jing Luo, Yongying Yang, Yibing Shen, Lin Su, Liming Yang
High-spectral-resolution lidar (HSRL) is a powerful tool for atmospheric aerosol remote sensing. The current HSRL technique often requires a single longitudinal mode laser as the transmitter to accomplish the spectral discrimination of the aerosol and molecular scattering conveniently. However, single-mode laser is cumbersome and has very strict requirements for ambient stability, making the HSRL instrument not so robust in many cases. In this paper, a new HSRL concept, called generalized HSRL technique with a multimode laser (MML-gHSRL), is proposed, which can work using a multimode laser...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28099601/psoriasis-comorbidities-complications-and-benefits-of-immunobiological-treatment
#14
REVIEW
André Vicente Esteves de Carvalho, Ricardo Romiti, Cacilda da Silva Souza, Renato Soriani Paschoal, Laura de Mattos Milman, Luana Pizarro Meneghello
During the last decade, different studies have converged to evidence the high prevalence of comorbidities in subjects with psoriasis. Although a causal relation has not been fully elucidated, genetic relation, inflammatory pathways and/or common environmental factors appear to be underlying the development of psoriasis and the metabolic comorbidities. The concept of psoriasis as a systemic disease directed the attention of the scientific community in order to investigate the extent to which therapeutic interventions influence the onset and evolution of the most prevalent comorbidities in patients with psoriasis...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28072590/incorporating-the-patient-s-perspective-in-outcomes-research
#15
Betty Hsiao, Liana Fraenkel
PURPOSE OF REVIEW: Incorporation of the patients' perspective in clinical research is critical to ensure that outcomes measured reflect those, which matter most to patients. This review summarizes recent efforts to include the patients' perspective in the development of outcome measures and the importance of encouraging patient participation in decision-making and self-management. RECENT FINDINGS: Since the inclusion of fatigue as a patient-endorsed core outcome measure in rheumatoid arthritis (RA) trials, OMERACT has been instrumental in advocating for patient involvement in the development of core domains and instruments; current endeavors include cultivating an understanding of remission through the eyes of patients and gaining a sense of how to measure features of pain and 'stiffness' deemed as important to patients...
March 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28072449/a-survival-guide-to-landsat-preprocessing
#16
Nicholas E Young, Ryan S Anderson, Stephen M Chignell, Anthony G Vorster, Rick Lawrence, Paul H Evangelista
Landsat data are increasingly used for ecological monitoring and research. These data often require preprocessing prior to analysis to account for sensor, solar, atmospheric, and topographic effects. However, ecologists using these data are faced with a literature containing inconsistent terminology, outdated methods, and a vast number of approaches with contradictory recommendations. These issues can, at best, make determining the correct preprocessing workflow a difficult and time-consuming task and, at worst, lead to erroneous results...
April 2017: Ecology
https://www.readbyqxmd.com/read/28047960/tu-b-206-02-on-the-algorithmic-approach-to-ethical-conduct
#17
G Sherouse
PURPOSE: To reacquaint the participant with foundational aspects of educational, healthcare and research ethics as they relate to the Medical Physicist day to day role. METHODS: Presenting recognized best practice guidelines and tenants applied to hypothetical scenarios and medical physics related occupations. RESULTS: The application of recognized standards of ethical behavior result in beneficial outcomes for all involved CONCLUSION: Ethics is multi-faceted in its manifestation application; most facets are applicable to any avenue a medical physicist may pursue in their career...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047495/su-f-e-15-initial-experience-implementing-a-case-method-teaching-approach-to-radiation-oncology-physics-residents-graduate-students-and-doctorate-of-medical-physics-students
#18
A Gutierrez
PURPOSE: Case Method Teaching approach is a teaching tool used commonly in business school to challenge students with real-world situations-i.e. CASES: The students are placed in the role of the decision maker and have to provide a solution based on the multitude of information provided. Specifically, students must develop an ability to quickly make sense of a complex problem, provide a solution incorporating all of the objectives (at time conflicting) and constraints, and communicate that solution in a succinct, professional and effective manner...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047387/tu-b-206-00-do-the-right-thing
#19
Jeffrey Limmer
PURPOSE: To reacquaint the participant with foundational aspects of educational, healthcare and research ethics as they relate to the Medical Physicist day to day role. METHODS: Presenting recognized best practice guidelines and tenants applied to hypothetical scenarios and medical physics related occupations. RESULTS: The application of recognized standards of ethical behavior result in beneficial outcomes for all involved CONCLUSION: Ethics is multi-faceted in its manifestation application; most facets are applicable to any avenue a medical physicist may pursue in their career...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046722/tu-b-206-01-navigating-the-black-white-and-gray
#20
J Limmer
PURPOSE: To reacquaint the participant with foundational aspects of educational, healthcare and research ethics as they relate to the Medical Physicist day to day role. METHODS: Presenting recognized best practice guidelines and tenants applied to hypothetical scenarios and medical physics related occupations. RESULTS: The application of recognized standards of ethical behavior result in beneficial outcomes for all involved CONCLUSION: Ethics is multi-faceted in its manifestation application; most facets are applicable to any avenue a medical physicist may pursue in their career...
June 2016: Medical Physics
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