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https://www.readbyqxmd.com/read/29747458/filament-advance-detection-sensor-for-fused-deposition-modelling-3d-printers
#1
Enrique Soriano Heras, Fernando Blaya Haro, José M de Agustín Del Burgo, Manuel Islán Marcos, Roberto D'Amato
The main purpose of this paper is to present a system to detect extrusion failures in fused deposition modelling (FDM) 3D printers by sensing that the filament is moving forward properly. After several years using these kind of machines, authors detected that there is not any system to detect the main problem in FDM machines. Authors thought in different sensors and used the weighted objectives method, one of the most common evaluation methods, for comparing design concepts based on an overall value per design concept...
May 9, 2018: Sensors
https://www.readbyqxmd.com/read/29735741/folding-cooperativity-and-allosteric-function-in-the-tandem-repeat-protein-class
#2
REVIEW
Albert Perez-Riba, Marie Synakewicz, Laura S Itzhaki
The term allostery was originally developed to describe structural changes in one binding site induced by the interaction of a partner molecule with a distant binding site, and it has been studied in depth in the field of enzymology. Here, we discuss the concept of action at a distance in relation to the folding and function of the solenoid class of tandem-repeat proteins such as tetratricopeptide repeats (TPRs) and ankyrin repeats. Distantly located repeats fold cooperatively, even though only nearest-neighbour interactions exist in these proteins...
June 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29723702/dynamic-shear-lag-model-for-understanding-the-role-of-matrix-in-energy-dissipation-in-fiber-reinforced-composites
#3
Junjie Liu, Wenqing Zhu, Zhongliang Yu, Xiaoding Wei
Lightweight and high impact performance composite design is a big challenge for scientists and engineers. Inspired from well-known biological materials, e.g., the bones, spider silk, and claws of mantis shrimp, artificial composites have been synthesized for engineering applications. Presently, the design of ballistic resistant composites mainly emphasizes the utilization of light and high-strength fibers, whereas the contribution from matrix materials receives less attention. However, recent ballistic experiments on fiber-reinforced composites challenge our common sense...
April 30, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29628964/exploring-the-needs-of-family-caregivers-of-children-with-attention-deficit-hyperactivity-disorder-a-qualitative-study
#4
Saeid Pahlavanzadeh, Sharifeh Mousavi, Jahangir Maghsoudi
Background: Attention deficit hyperactivity disorder (ADHD) is one of the most common chronic childhood disorders that lead to dysfunction and disability in childhood and subsequently be careful. This study aimed to understand the needs of the children's caregivers in Iran. Materials and Methods: This qualitative research was conducted in 2016. Using purposive sampling, 27 participants from 20 families of children with ADHD were interviewed. Unstructured interviews were conducted within 6 months in Isfahan...
March 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29592645/being-suspicious-of-the-sense-of-ease-and-undeterred-by-the-sense-of-difficulty-looking-back-at-schmidt-and-bjork-1992
#5
Robert A Bjork
Richard Schmidt and I titled our article "New Conceptualizations of Practice: Common Principles in Three Paradigms Suggest New Concepts for Training" to reflect our view that prevailing ideas about how to optimize teaching, learning, and practicing were, in our words, "at best incomplete, and at worst incorrect." We argued that teachers and trainers were susceptible to being misled by two commonsense assumptions-namely, that procedures that enhance performance during training are the procedures of choice and that the context of training needs to match in detail the posttraining context that is the target of training...
March 2018: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29568469/supramolecular-assembly-affording-a-ratiometric-two-photon-fluorescent-nanoprobe-for-quantitative-detection-and-bioimaging
#6
Peng Wang, Cheng Zhang, Hong-Wen Liu, Mengyi Xiong, Sheng-Yan Yin, Yue Yang, Xiao-Xiao Hu, Xia Yin, Xiao-Bing Zhang, Weihong Tan
Fluorescence quantitative analyses for vital biomolecules are in great demand in biomedical science owing to their unique detection advantages with rapid, sensitive, non-damaging and specific identification. However, available fluorescence strategies for quantitative detection are usually hard to design and achieve. Inspired by supramolecular chemistry, a two-photon-excited fluorescent supramolecular nanoplatform ( TPSNP ) was designed for quantitative analysis with three parts: host molecules (β-CD polymers), a guest fluorophore of sensing probes (Np-Ad) and a guest internal reference (NpRh-Ad)...
December 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29537414/james-lind-and-the-disclosure-of-failure
#7
S Justman
Though James Lind is renowned as a pioneer of the clinical trial, he records the 1747 trial aboard the Salisbury in passing, never followed up on it, never campaigned for clinical trials as a means of medical discovery, and eventually pronounced scurvy an insoluble enigma. The case can be made that in confessing his lack of an unfailing remedy for scurvy and his trouble making sense of the disease's behaviour, Lind did medicine a greater service than by conducting his now-famous trial. At the time, medical progress was hindered by the all-too-common practice of proclaiming success and concealing failure...
December 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29517100/biosynthesis-and-incorporation-of-an-alkylproline-derivative-apd-precursor-into-complex-natural-products
#8
J Janata, Z Kamenik, R Gazak, S Kadlcik, L Najmanova
Covering: up to 2017This review covers the biosynthetic and evolutionary aspects of lincosamide antibiotics, antitumour pyrrolobenzodiazepines (PBDs) and the quorum-sensing molecule hormaomycin. These structurally and functionally diverse groups of complex natural products all incorporate rarely occurring 4-alkyl-l-proline derivatives (APDs) biosynthesized from l-tyrosine through an unusual specialized pathway catalysed by a common set of six proteins named Apd1-Apd6. We give an overview of APD formation, which involves unusual enzyme activities, and its incorporation, which is based either on nonribosomal peptide synthetase (PBDs, hormaomycin) or a unique hybrid ergothioneine-dependent condensation system followed by mycothiol-dependent sulphur atom incorporation (lincosamides)...
March 1, 2018: Natural Product Reports
https://www.readbyqxmd.com/read/29487579/hervs-new-role-in-cancer-from-accused-perpetrators-to-cheerful-protectors
#9
REVIEW
Norbert Bannert, Henning Hofmann, Adriana Block, Oliver Hohn
Initial indications that retroviruses are connected to neoplastic transformation were seen more than a century ago. This concept has also been tested for endogenized retroviruses (ERVs) that are abundantly expressed in many transformed cells. In healthy cells, ERV expression is commonly prevented by DNA methylation and other epigenetic control mechanisms. ERVs are remnants of former exogenous forms that invaded the germ line of the host and have since been vertically transmitted. Several examples of ERV-induced genomic recombination events and dysregulation of cellular genes that contribute to tumor formation have been well documented...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29449097/-the-unhealthy-other-how-vaccine-rejecting-parents-construct-the-vaccinating-mainstream
#10
Katie Attwell, David T Smith, Paul R Ward
To address the phenomenon of vaccine hesitancy and rejection, researchers increasingly recognise the need to engage with the social context of parents' decision-making. This study examines how vaccine rejecting parents socially construct the vaccinating mainstream in opposition to themselves. We analyse qualitative data from interviews with parents in Adelaide, South Australia. Applying insights from Social Identity Theory (SIT), we show how these parents bolster their own sense of identity and self-belief by employing a discourse that casts vaccinators as an Unhealthy Other...
March 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29434461/emotional-consequences-of-delays-in-spinal-rehabilitation-unit-admission-or-discharge-a-qualitative-study-on-the-importance-of-communication
#11
Narelle Warren, Karin Walford, Annisha Susilo, Peter Wayne New
Objective : To explore the influence of health communications on the emotional consequences of delays in transfer from acute hospital into a spinal rehabilitation unit (SRU) or delays in discharge from SRU. Methods: Semi-structured interviews were conducted in this exploratory, thematic qualitative research design in an SRU, Melbourne, Australia. Results : Six patients experienced delay in admission to ( n = 4) or discharge from ( n = 3) the SRU, with one person experiencing both an admission and discharge delay...
2018: Topics in Spinal Cord Injury Rehabilitation
https://www.readbyqxmd.com/read/29402582/birth-experiences-trauma-responses-and-self-concept-in-postpartum-psychotic-like-experiences
#12
Lyndsey Holt, William Sellwood, Pauline Slade
The frequency of psychotic-like experiences (PLEs) amongst new mothers is beginning to be explored but the mechanisms underlying such experiences are yet to be understood. First time mothers (N=10,000) receiving maternity care via the UK National Health Service were contacted postnatally via Emma's Diary, an online resource for mothers. Measures assessed birth experience, trauma appraisals, post-traumatic stress symptoms, adjustment to motherhood, self-concept clarity and PLEs (in the form of hallucinations and delusions)...
February 2, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29370075/another-round-of-clue-to-uncover-the-mystery-of-complex-traits
#13
REVIEW
Shefali Setia Verma, Marylyn D Ritchie
A plethora of genetic association analyses have identified several genetic risk loci. Technological and statistical advancements have now led to the identification of not only common genetic variants, but also low-frequency variants, structural variants, and environmental factors, as well as multi-omics variations that affect the phenotypic variance of complex traits in a population, thus referred to as complex trait architecture. The concept of heritability, or the proportion of phenotypic variance due to genetic inheritance, has been studied for several decades, but its application is mainly in addressing the narrow sense heritability (or additive genetic component) from Genome-Wide Association Studies (GWAS)...
January 25, 2018: Genes
https://www.readbyqxmd.com/read/29358683/sieving-through-gut-models-of-colonization-resistance
#14
REVIEW
Caroline Mullineaux-Sanders, Jotham Suez, Eran Elinav, Gad Frankel
The development of innovative high-throughput genomics and metabolomics technologies has considerably expanded our understanding of the commensal microorganisms residing within the human body, collectively termed the microbiota. In recent years, the microbiota has been reported to have important roles in multiple aspects of human health, pathology and host-pathogen interactions. One function of commensals that has attracted particular interest is their role in protection against pathogens and pathobionts, a concept known as colonization resistance...
February 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29341970/does-the-use-of-indirect-calorimetry-change-outcome-in-the-icu-yes-it-does
#15
Elisabeth De Waele, Patrick M Honoré, Manu L N G Malbrain
PURPOSE OF REVIEW: To review the recent findings on metabolic monitoring and possible beneficial effects of an adequate nutrition therapy, based on indirect calorimetry as the golden standard to predict energy expenditure. RECENT FINDINGS: in the last decades, major steps are taken in the field of metabolism and nutrition, evolving from nutrition as a baseline support to a therapeutic intervention. The aspect of energy expenditure is of cardinal importance, and technical possibilities have impressively improved: from the first 'calorimetre' in 1789 to the new generation, clinical applicable indirect calorimeters and the high accuracy and easy use model reaching high technology readiness level [Oshima et al...
March 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29330580/-lichen-ruber-planus-better-understanding-better-treatment
#16
REVIEW
L Schilling, T Vogt
Lichen ruber, also called lichen ruber planus or lichen planus (LP), is a noncontagious inflammatory skin disease. LP is the main representative and namesake of the group of lichenoid diseases, which are characterized by small papules often accompanied by severe itching. With 65% of cases, LP is primarily a disease of the mucous membranes. In 20% of the cases, the disease is found on the skin and mucous membranes; skin involvement alone is seen in only about 10% of cases. Cutaneous LP has a very favorable 1‑year prognosis of almost 80% healing as opposed to the mucosa and the adnexal organs...
February 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29313524/multichannel-spectrometers-in-animals
#17
Thomas Wells Cronin, Missael Garcia, Viktor Gruev
Multispectral, hyperspectral, polarimetric, and other types of multichannel imaging spectrometers are coming into common use for a variety of applications, including remote sensing, material identification, forensics, and medical diagnosis. These instruments are often bulky and intolerant of field abuse, so designing compact, reliable, portable, and robust devices is a priority. In contrast to most engineering designs, animals have been building compact and robust multichannel imaging systems for millennia - their eyes...
January 9, 2018: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29259153/application-of-optimal-band-limited-control-protocols-to-quantum-noise-sensing
#18
V M Frey, S Mavadia, L M Norris, W de Ferranti, D Lucarelli, L Viola, M J Biercuk
Essential to the functionality of qubit-based sensors are control protocols, which shape their response in frequency space. However, in common control routines out-of-band spectral leakage complicates interpretation of the sensor's signal. In this work, we leverage discrete prolate spheroidal sequences (a.k.a. Slepian sequences) to synthesize provably optimal narrowband controls ideally suited to spectral estimation of a qubit's noisy environment. Experiments with trapped ions demonstrate how spectral leakage may be reduced by orders of magnitude over conventional controls when a near resonant driving field is modulated by Slepians, and how the desired narrowband sensitivity may be tuned using concepts from RF engineering...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29236805/psychoanalysis-as-a-belief-system-a-research-program-outline
#19
Mariano Ben Plotkin
This article lays out an agenda for research on the establishment of psy cultures in Latin America. It begins by analyzing some of the debates on the nature of psychoanalysis, a discipline located between the sciences, philosophy and common sense. It argues that the place of psy cultures needs to be problematized as emerging out of modernity in a cultural space like Latin America, where the very concept of modernity differs greatly from that of central countries.
November 2017: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/29236676/supervised-learning-and-knowledge-based-approaches-applied-to-biomedical-word-sense-disambiguation
#20
Rui Antunes, Sérgio Matos
Word sense disambiguation (WSD) is an important step in biomedical text mining, which is responsible for assigning an unequivocal concept to an ambiguous term, improving the accuracy of biomedical information extraction systems. In this work we followed supervised and knowledge-based disambiguation approaches, with the best results obtained by supervised means. In the supervised method we used bag-of-words as local features, and word embeddings as global features. In the knowledge-based method we combined word embeddings, concept textual definitions extracted from the UMLS database, and concept association values calculated from the MeSH co-occurrence counts from MEDLINE articles...
December 13, 2017: Journal of Integrative Bioinformatics
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