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https://www.readbyqxmd.com/read/29330580/-lichen-ruber-planus-better-understanding-better-treatment
#1
REVIEW
L Schilling, T Vogt
Lichen ruber, also called lichen ruber planus or lichen planus (LP), is a noncontagious inflammatory skin disease. LP is the main representative and namesake of the group of lichenoid diseases, which are characterized by small papules often accompanied by severe itching. With 65% of cases, LP is primarily a disease of the mucous membranes. In 20% of the cases, the disease is found on the skin and mucous membranes; skin involvement alone is seen in only about 10% of cases. Cutaneous LP has a very favorable 1‑year prognosis of almost 80% healing as opposed to the mucosa and the adnexal organs...
January 12, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29313524/multichannel-spectrometers-in-animals
#2
Thomas Wells Cronin, Missael Garcia, Viktor Gruev
Multispectral, hyperspectral, polarimetric, and other types of multichannel imaging spectrometers are coming into common use for a variety of applications, including remote sensing, material identification, forensics, and medical diagnosis. These instruments are often bulky and intolerant of field abuse, so designing compact, reliable, portable, and robust devices is a priority. In contrast to most engineering designs, animals have been building compact and robust multichannel imaging systems for millennia - their eyes...
January 9, 2018: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29259153/application-of-optimal-band-limited-control-protocols-to-quantum-noise-sensing
#3
V M Frey, S Mavadia, L M Norris, W de Ferranti, D Lucarelli, L Viola, M J Biercuk
Essential to the functionality of qubit-based sensors are control protocols, which shape their response in frequency space. However, in common control routines out-of-band spectral leakage complicates interpretation of the sensor's signal. In this work, we leverage discrete prolate spheroidal sequences (a.k.a. Slepian sequences) to synthesize provably optimal narrowband controls ideally suited to spectral estimation of a qubit's noisy environment. Experiments with trapped ions demonstrate how spectral leakage may be reduced by orders of magnitude over conventional controls when a near resonant driving field is modulated by Slepians, and how the desired narrowband sensitivity may be tuned using concepts from RF engineering...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29236805/psychoanalysis-as-a-belief-system-a-research-program-outline
#4
Mariano Ben Plotkin
This article lays out an agenda for research on the establishment of psy cultures in Latin America. It begins by analyzing some of the debates on the nature of psychoanalysis, a discipline located between the sciences, philosophy and common sense. It argues that the place of psy cultures needs to be problematized as emerging out of modernity in a cultural space like Latin America, where the very concept of modernity differs greatly from that of central countries.
November 2017: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/29236676/supervised-learning-and-knowledge-based-approaches-applied-to-biomedical-word-sense-disambiguation
#5
Rui Antunes, Sérgio Matos
Word sense disambiguation (WSD) is an important step in biomedical text mining, which is responsible for assigning an unequivocal concept to an ambiguous term, improving the accuracy of biomedical information extraction systems. In this work we followed supervised and knowledge-based disambiguation approaches, with the best results obtained by supervised means. In the supervised method we used bag-of-words as local features, and word embeddings as global features. In the knowledge-based method we combined word embeddings, concept textual definitions extracted from the UMLS database, and concept association values calculated from the MeSH co-occurrence counts from MEDLINE articles...
December 13, 2017: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/29235451/towards-a-theoretical-clarification-of-biomimetics-using-conceptual-tools-from-engineering-design
#6
M Drack, M Limpinsel, G de Bruyn, J H Nebelsick, O Betz
Many successful examples of biomimetic products are available, and most research efforts in this emerging field are directed towards the development of specific applications. The theoretical and conceptual underpinnings of the knowledge transfer between biologists, engineers and architects are, however, poorly investigated. The present article addresses this gap. We use a 'technomorphic' approach, i.e. the application of conceptual tools derived from engineering design, to better understand the processes operating during a typical biomimetic research project...
December 13, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29202313/comparing-interprofessional-and-interorganizational-collaboration-in-healthcare-a-systematic-review-of-the-qualitative-research
#7
REVIEW
Marlène Karam, Isabelle Brault, Thérèse Van Durme, Jean Macq
BACKGROUND: Interprofessional and interorganizational collaboration have become important components of a well-functioning healthcare system, all the more so given limited financial resources, aging populations, and comorbid chronic diseases. The nursing role in working alongside other healthcare professionals is critical. By their leadership, nurses can create a culture that encourages values and role models that favour collaborative work within a team context. OBJECTIVES: To clarify the specific features of conceptual frameworks of interprofessional and interorganizational collaboration in the healthcare field...
November 11, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29190538/research-altruism-as-motivation-for-participation-in-community-centered-environmental-health-research
#8
Jennifer S Carrera, Phil Brown, Julia Green Brody, Rachel Morello-Frosch
Protection of human subjects in research typically focuses on extrinsic rather than intrinsic motivations for participation in research. Recent sociological literature on altruism suggests that multiple kinds of altruism exist and are grounded in a sense of connection to common humanity. We interviewed participants in eight community-centered research studies that sampled for endocrine disrupting compounds and that shared research findings with participants. The results of our analysis of participation in these studies indicate that altruistic motivations were commonly held...
November 21, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29163530/sense-and-immunity-context-dependent-neuro-immune-interplay
#9
REVIEW
Simmie L Foster, Corey R Seehus, Clifford J Woolf, Sébastien Talbot
The sensory nervous and immune systems, historically considered autonomous, actually work in concert to promote host defense and tissue homeostasis. These systems interact with each other through a common language of cell surface G protein-coupled receptors and receptor tyrosine kinases as well as cytokines, growth factors, and neuropeptides. While this bidirectional communication is adaptive in many settings, helping protect from danger, it can also become maladaptive and contribute to disease pathophysiology...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29124848/quantitative-chemical-biosensing-by-bacterial-chemotaxis-in-microfluidic-chips
#10
Clémence Roggo, Cristian Picioreanu, Xavier Richard, Christian Mazza, Harald van Lintel, Jan Roelof van der Meer
Whole-cell bacterial bioreporters are proposed as alternatives to chemical analysis of, e.g., pollutants in environmental compartments. Commonly based on reporter gene induction, bioreporters produce a detectable signal within 30 min to a few hours after exposure to the chemical target, which is impractical for applications aiming at a fast response. In an attempt to attain faster readout but maintain flexibility of chemical targeting, we explored the concept for quantitative chemical sensing by bacterial chemotaxis...
November 10, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29110591/optical-sensors-for-detection-of-amino-acids
#11
Aafrin M Pettiwala, Prabhat K Singh
BACKGROUND: Amino acids are crucially involved in a myriad of biological processes. Any aberrant changes in physiological level of amino acids often manifest in common metabolic disorders, serious neurological conditions and cardiovascular diseases. Thus, devising methods for detection of trace amounts of amino acids becomes highly elemental to their efficient clinical diagnosis. Recently, the domain of developing optical sensors for detection of amino acids has witnessed significant activity which is the focus of the current review article...
November 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29083011/nanoparticle-based-optical-sensor-arrays
#12
REVIEW
Arafeh Bigdeli, Forough Ghasemi, Hamed Golmohammadi, Samira Abbasi-Moayed, M Amin Farahmand Nejad, Nafiseh Fahimi-Kashani, Somayeh Jafarinejad, Maryam Shahrajabian, M Reza Hormozi-Nezhad
As in many other methods that have integrated nanoparticles (NPs), the chemical nose/tongue strategy has also progressed greatly since the entrance of NPs into this field. The fascinating tunable physicochemical properties of NPs have made them powerful candidates for array-based sensing platforms and have enabled the development of real-time, sensitive and portable systems that are able to target complex mixtures of analytes. In particular, the unique optical properties of NPs have a key role in providing promising array-based sensing approaches...
November 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/29077790/precision-medicine-needs-pioneering-clinical-bioinformaticians
#13
Gonzalo Gómez-López, Joaquín Dopazo, Juan C Cigudosa, Alfonso Valencia, Fátima Al-Shahrour
Success in precision medicine depends on accessing high-quality genetic and molecular data from large, well-annotated patient cohorts that couple biological samples to comprehensive clinical data, which in conjunction can lead to effective therapies. From such a scenario emerges the need for a new professional profile, an expert bioinformatician with training in clinical areas who can make sense of multi-omics data to improve therapeutic interventions in patients, and the design of optimized basket trials. In this review, we first describe the main policies and international initiatives that focus on precision medicine...
October 25, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29072718/field-effect-sensors-from-ph-sensing-to-biosensing-sensitivity-enhancement-using-streptavidin-biotin-as-a-model-system
#14
REVIEW
Benjamin M Lowe, Kai Sun, Ioannis Zeimpekis, Chris-Kriton Skylaris, Nicolas G Green
Field-Effect Transistor sensors (FET-sensors) have been receiving increasing attention for biomolecular sensing over the last two decades due to their potential for ultra-high sensitivity sensing, label-free operation, cost reduction and miniaturisation. Whilst the commercial application of FET-sensors in pH sensing has been realised, their commercial application in biomolecular sensing (termed BioFETs) is hindered by poor understanding of how to optimise device design for highly reproducible operation and high sensitivity...
October 26, 2017: Analyst
https://www.readbyqxmd.com/read/29070916/clusters-of-cultures-diversity-in-meaning-of-family-value-and-gender-role-items-across-europe
#15
Eva van Vlimmeren, Guy B D Moors, John P T M Gelissen
Survey data are often used to map cultural diversity by aggregating scores of attitude and value items across countries. However, this procedure only makes sense if the same concept is measured in all countries. In this study we argue that when (co)variances among sets of items are similar across countries, these countries share a common way of assigning meaning to the items. Clusters of cultures can then be observed by doing a cluster analysis on the (co)variance matrices of sets of related items. This study focuses on family values and gender role attitudes...
2017: Quality & Quantity
https://www.readbyqxmd.com/read/28967775/maternal-conception-of-gestational-weight-gain-among-latinas-a-qualitative-study
#16
Grace E Fletcher, Leah Teeters, David Schlundt, Kemberlee Bonnet, William J Heerman
OBJECTIVE: Interventions to support healthy gestational weight gain are often ineffective. The objective was to develop a model of how pregnant Latinas-who have a higher risk of poor maternal and neonatal weight-related outcomes-conceptualize healthy gestational weight gain, providing guidance for future interventions. METHOD: Ten focus groups with 50 pregnant Latinas were conducted by a native Spanish-speaking female moderator. On the basis of participant responses, we used grounded theory to inductively develop a personal conceptual framework for gestational weight gain...
October 2, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28899576/neuroscience-and-everyday-life-facing-the-translation-problem
#17
Jolien C Francken, Marc Slors
To enable the impact of neuroscientific insights on our daily lives, careful translation of research findings is required. However, neuroscientific terminology and common-sense concepts are often hard to square. For example, when neuroscientists study lying to allow the use of brain scans for lie-detection purposes, the concept of lying in the scientific case differs considerably from the concept in court. Furthermore, lying and other cognitive concepts are used unsystematically and have an indirect and divergent mapping onto brain activity...
September 10, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28894245/an-extremely-simple-macroscale-electronic-skin-realized-by-deep-machine-learning
#18
Kee-Sun Sohn, Jiyong Chung, Min-Young Cho, Suman Timilsina, Woon Bae Park, Myungho Pyo, Namsoo Shin, Keemin Sohn, Ji Sik Kim
Complicated structures consisting of multi-layers with a multi-modal array of device components, i.e., so-called patterned multi-layers, and their corresponding circuit designs for signal readout and addressing are used to achieve a macroscale electronic skin (e-skin). In contrast to this common approach, we realized an extremely simple macroscale e-skin only by employing a single-layered piezoresistive MWCNT-PDMS composite film with neither nano-, micro-, nor macro-patterns. It is the deep machine learning that made it possible to let such a simple bulky material play the role of a smart sensory device...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881409/an-emerging-new-risk-analysis-science-foundations-and-implications
#19
Terje Aven
To solve real-life problems-such as those related to technology, health, security, or climate change-and make suitable decisions, risk is nearly always a main issue. Different types of sciences are often supporting the work, for example, statistics, natural sciences, and social sciences. Risk analysis approaches and methods are also commonly used, but risk analysis is not broadly accepted as a science in itself. A key problem is the lack of explanatory power and large uncertainties when assessing risk. This article presents an emerging new risk analysis science based on novel ideas and theories on risk analysis developed in recent years by the risk analysis community...
September 7, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28845564/demographics-farm-and-reproductive-management-strategies-used-in-australian-automatic-milking-systems-compared-with-regionally-proximal-conventional-milking-systems
#20
D M Keeper, K L Kerrisk, J K House, S C Garcia, P Thomson
OBJECTIVE: To determine the management practices utilised in automatic milking systems (AMS) that affect reproductive management and performance and how these compare with the management practices used in regionally proximal conventional milking systems (CMS). METHODS: This study examined demographic and management data from AMS and CMS dairy farms through a survey, with a specific focus on reproductive management procedures. RESULTS: Overall, responses from AMS and CMS dairy farms showed little difference in terms of respondent demographics, farm size, herd structure and most farm management strategies...
September 2017: Australian Veterinary Journal
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