Riccardo Panella, Andreas Petri, Bhavna N Desai, Sharmila Fagoonee, Cody A Cotton, Piercen K Nguyen, Eric M Lundin, Alexandre Wagshal, Da-Zhi Wang, Anders M Näär, Ioannis S Vlachos, Eleftheria Maratos-Flier, Fiorella Altruda, Sakari Kauppinen, Pier Paolo Pandolfi
Obesity is a growing public health problem associated with increased risk of type 2 diabetes, cardiovascular disease, nonalcoholic fatty liver disease (NAFLD) and cancer. Here, we identify microRNA-22 (miR-22) as an essential rheostat involved in the control of lipid and energy homeostasis as well as the onset and maintenance of obesity. We demonstrate through knockout and transgenic mouse models that miR-22 loss-of-function protects against obesity and hepatic steatosis, while its overexpression promotes both phenotypes even when mice are fed a regular chow diet...
August 17, 2023: International Journal of Molecular Sciences