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https://www.readbyqxmd.com/read/25125946/n-acetylcycsteine-attenuates-the-deleterious-effects-of-radiation-therapy-on-inci-sional-wound-healing-in-rats
#1
O Tascilar, Gk Cakmak, Au Emre, H Bakkal, N Kandemir, Uo Turkcu, Eo Demir
BACKGROUND: During preoperative radiotherapy, effective doses of ionizing radiation occasionally cause wound complications after subsequent surgery. This study was designed to determine the effects of intraperitoneally or orally administered N-acetylcysteine (NAC) on anastomotic healing of irradiated rats. MATERIAL & METHODS: Forty Wistar albino rats were randomized into four groups containing 10 rats each. A 3 cm long surgical full-thickness midline laparotomy was performed to all groups (Groups 1-4)...
January 2014: Hippokratia
https://www.readbyqxmd.com/read/20967313/uranyl-nitrate-complex-extraction-into-tbp-dodecane-organic-solutions-a-molecular-dynamics-study
#2
Xianggui Ye, Shengting Cui, Valmor F de Almeida, Benjamin P Hay, Bamin Khomami
Liquid-liquid extraction of uranyl is studied by conducting atomistic molecular dynamics simulation using quantum chemistry calibrated force fields via restrained electrostatic potential fitting of atomic forces. The simulations depict the migration of uranyl nitrate complexes from the aqueous-organic interface into the tri-n-butyl phosphate (TBP)/dodecane organic phase, in the form of UO(2)(NO(3))(2)·H(2)O·2TBP and UO(2)(NO(3))(2)·3TBP. The migration process is characterized by the gradual breaking of all the hydrogen bonds between the complex and the water molecules at the interface...
December 21, 2010: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/17107142/the-initial-stage-of-uranium-oxidation-mechanism-of-uo-2-scale-formation-in-the-presence-of-a-native-lateral-stress-field
#3
Z Chernia, Y Ben-Eliyahu, G Kimmel, G Braun, J Sariel
In this work, an oxidation model for alpha-uranium is presented. It describes the internally lateral stress field built in the oxide scale during the reaction. The thickness of the elastic, stress-preserving oxide (UO(2+x)) scale is less than 0.5 microm. A lateral, 6.5 GPa stress field has been calculated from strains derived from line shifts (delta(2theta)) as measured by the X-ray diffraction of UO(2). It is shown that in the elastic growth domain, (110) is the main UO(2) growth plane for gas-solid oxidation...
November 23, 2006: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/15380636/microparticle-formation-and-its-mechanism-in-single-and-double-emulsion-solvent-evaporation
#4
Iosif Daniel Rosca, Fumio Watari, Motohiro Uo
The emulsification is the first step of the emulsification solvent evaporation method and has been extensively investigated. On the contrary the second step, the solvent transport out from the emulsion droplets that determine the particle morphology and with great influence on the microparticles encapsulation and release behavior has been scarcely studied. This study investigates the mechanism of the solvent elimination from the emulsion droplets and its influence on the particle morphology, encapsulation and release behavior...
September 30, 2004: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/10462535/dna-protein-cross-links-produced-by-nsc-652287-a-novel-thiophene-derivative-active-against-human-renal-cancer-cells
#5
W Nieves-Neira, M I Rivera, G Kohlhagen, M L Hursey, P Pourquier, E A Sausville, Y Pommier
2, 5-bis(5-Hydroxymethyl-2-thienyl)furan (NSC 652287), is a representative of a series of thiophene derivatives that exhibit potent and selective antitumor activity against several tumor cell lines in the National Cancer Institute Anticancer Drug Screen. NSC 652287 has noticeable activity for the renal cell lines and produces cures in certain corresponding xenografts. The cellular mechanisms of action of NSC 652287 were therefore investigated in this study in greater detail. The most sensitive renal carcinoma cell line, A498, exhibited cell cycle arrest in G(0)-G(1) and G(2)-M at 10 nM NSC 652287, with increased p53 and p21(WAF1) protein...
September 1999: Molecular Pharmacology
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