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Nano drug delivery

Shufang Dong, Xin Zhou, Jiying Yang
BACKGROUND: Co-delivery of anticancer drugs and gene is promising to generate synergistic anticancer effects. Surface modification of nanocarriers with specific ligands could further assist in targeting and internalization of the nanocarriers into specific cell populations, such as cancers and disease organs. PURPOSE: The aim of the study reported here is to develop Cell-penetrating peptides (CPPs) modified lipid - PEI hybrid nanoparticles (LPNs) for effective co-delivery of docetaxel (DTX) and plasmid DNA (pDNA) for combination chemotherapy...
October 17, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Kunihiko Watanabe
It is becoming well-known that bacterial cells produce membrane vesicles (MVs) from the cell surface in a budding manner, whereas the detailed mechanisms of MV biogenesis remain unclear. MVs are not authentic cells, since they are observed to be between 20 and 300 nm in size but have a structure close to the subcellular compartments. In a sense, the structure of MVs containing biogenic and cellular substances and their behavior look similar to those of viruses. Due to these scientific facts, several potent applications employing MVs as a promising tool have been proposed and reported...
October 19, 2016: Applied Microbiology and Biotechnology
Pramod Kumar, Gajanand Sharma, Rajendra Kumar, Bhupinder Singh, Ruchi Malik, Om Prakash Katare, Kaisar Raza
In various neurological disorders, antioxidants are frequently prescribed along with the specific treatment modalities. One such promising natural flavonoid is quercetin, offering better outcomes than established vitamins E and C. Though with immense promises, various challenges like poor oral-bioavailability (<2%), extensive first-pass metabolism, poor brain permeability, hydrophobic nature and physiological pH instability hinder its proper usage. Hence, it was planned to prepare quercetin-loaded nano lipidic carriers (NLCs) employing biocompatible components like phospholipids and tocopherol acetate for enhanced brain delivery...
October 15, 2016: International Journal of Pharmaceutics
N R Datta, S Krishnan, D E Speiser, E Neufeld, N Kuster, S Bodis, H Hofmann
Effective multimodal cancer management requires the optimal integration of diagnostic and therapeutic modalities. Radiation therapy, chemotherapy and immunotherapy, alone or in combination, are integral parts of various cancer treatment protocols. Hyperthermia at 39-45°C is a potent radiosensitiser and has been shown to improve therapeutic outcomes in various tumours through its synergy with chemotherapy. Gene silencing approaches, using small interfering RNAs and microRNAs, are also being explored in clinical trials in oncology...
October 3, 2016: Cancer Treatment Reviews
Keren Turjeman, Yechezkel Barenholz
BACKGROUND: Steroids are the most efficacious anti-inflammatory agents. However, their toxicities and side-effects compromise their clinical application. Various strategies and major efforts were dedicated for formulating viable liposomal glucocorticosteroids (GCs), so far none of these were approved. OBJECTIVES: To evaluate these approaches for formulating GC-delivery systems, especially liposomes, and with focus on the Barenholz Lab experience. METHODS: We developed PEGylated nano-liposomes (NSSL) remotely loaded with water-soluble amphipathic weak acid GC-prodrugs...
October 18, 2016: Journal of Drug Targeting
Jasmyn S Abrams, Savannah E Howe, Nathalie Becerra, Punit Kohli, Vjollca Konjufca
In this work we report a protocol for synthesizing nano-size ovalbumin-functionalized polydiacetylene (PDA) liposomes (LP-Ova). We show that LP-Ova administered per-orally (p.o.) and subcutaneously (s.c.), without the use of adjuvants, induces high serum IgG1 titers. As reported previously using polystyrene nanoparticles (NPs), p.o.-primed mice developed high titers of IgG2c and intestinal IgA following s.c. boosting immunization with LP-Ova. In contrast, mice that received a single s.c. immunization with LP-Ova did not develop serum IgG2c or intestinal IgA antibodies...
October 17, 2016: Journal of Biomedical Materials Research. Part A
Stefano Perni, Polina Prokopovich
The efficient delivery of therapeutic molecules to the cartilage of joints is major obstacle in developing useful therapeutic interventions; hence, a targeted drug delivery system for this tissue is critical. We have overcome the challenge by developing a system that employs electrostatic attraction between the negatively charged constituents of cartilage and a positively charged polymer, Poly-beta amino esters (PBAEs). We have demonstrated cartilage uptake of Dexamethasone (DEX) covalently bound to the PBAE was doubled and retention in tissues prolonged compared to the equivalent dose of the commercial drug formulation...
October 13, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Shoriya Aruni Abdul Manaf, Gurumurthy Hedge, Uttam Kumar Mandal, Wong Tin Wui, Partha Roy
BACKGROUND: Nano-scale carbon systems are emerging alternatives in drug delivery and bioimaging applications of which they gradually replace the quantum dots characterized by toxic heavy metal content in the latter application. OBJECTIVE: The work intended to use carbon nanospheres synthesized from biowaste Sago bark for cancer cell imaging applications. METHODS: This study synthesised carbon nanospheres from biowaste Sago bark using a catalyst-free pyrolysis technique...
October 17, 2016: Current Drug Delivery
Elham Ajorlou, Ahmad Yari Khosroushahi
PURPOSE: The dawn of the state-of-the-art methods of cancer treatments, nano-based delivery systems, has dispensed with the mainstream chemotherapy for being inadequate in yielding productive results and the numerous reported side effects. The popularity of this complementary approach in the course of the last two decades has been primarily attributed to its capacity to elevate the therapeutic index of anticancer drugs as well as removing the impassable delivery barriers in solid tumors with the minimal damage to the normal tissues...
October 15, 2016: Cancer Chemotherapy and Pharmacology
Héloïse Ragelle, Fabienne Danhier, Véronique Préat, Robert Langer, Daniel G Anderson
Nanomedicine has emerged as a major field of academic research with direct impact on human health. While a first generation of products has been successfully commercialized and has significantly contributed to enhance patient's life, recent advances in material design and the emergence of new therapeutics are contributing to the development of more sophisticated systems. As the field matures, it is important to comprehend the challenges related to nanoparticle commercial development for a more efficient and predictable path to the clinic...
October 12, 2016: Expert Opinion on Drug Delivery
Yurun Shen, Mengying Hu, Liyan Qiu
AIM: In this study, we constructed a novel vector (BioPf-M-loaded Alg-microparticles [Alg-BioPf-M]) with nano-in-micro structure to improve the oral absorption of docetaxel (DTX) by sequentially dual-targeting functions toward intestine and sodium-dependent multivitamin transporter based on entrapping biotin-modified micelles into alginate microparticles. METHODS: A series of characteristics of this system was investigated, such as drug release, cellular uptake, transport pathway and the comprehensive in vivo studies including pharmacokinetic studies, anti-tumor activity and toxicity study...
October 12, 2016: Nanomedicine
Shanshan Hu, Tong Wang, Xibo Pei, He Cai, Junyu Chen, Xin Zhang, Qianbing Wan, Jian Wang
In the present study, a cell-penetrating peptide, the transactivating transcriptional factor (TAT) domain from HIV, was linked to PEGylated multi-walled carbon nanotubes (MWCNTs) to develop a highly effective antitumor drug delivery system. FITC was conjugated on MWCNTs-polyethylene glycol (PEG) and MWCNTs-PEG-TAT to provide fluorescence signal for tracing the cellular uptake of the nanocarrier. After loaded with an anticancer agent, doxorubicin (DOX) via π - π stacking interaction, the physicochemical characteristics, release profile and biological evaluation of the obtained nano-sized drug carrier were investigated...
December 2016: Nanoscale Research Letters
Takahisa Ohta, Yasuhiko Hashida, Fumiyoshi Yamashita, Mitsuru Hashida
A novel sustained release formulation of mitomycin C (MMC) was developed by employing single-walled carbon nanotubes (SWCNTs) wrapped by designed peptide with polyethylene glycol (PEG) modification (pegylation) as a nano-scale molecular platform. The amino groups of polycationic and amphiphilic H-(-Cys-Trp-Lys-Gly-)(-Lys-Trp-Lys-Gly-)6-OH [CWKG(KWKG)6] peptide associated with SWCNTs were modified using PEG with 12 units (PEG12) to improve the dispersion stability of the composite. Then thiol groups of peptide were conjugated with MMC using N-ε-maleimidocaproic acid (EMCA) as a linker via transformation of aziridine group of MMC...
2016: Biological & Pharmaceutical Bulletin
Nabiul Islam, Sudip Misra
The network of novel nano-material based nanodevices, known as nanoscale communication networks or nanonetworks has ushered a new communication paradigm in the terahertz band (0.1-10 THz). In this work, first we envisage an architecture of nanonetworks-based Coronary Heart Disease (CHD) monitoring, consisting of nano-macro interface (NM) and nanodevice-embedded Drug Eluting Stents (DESs), termed as nanoDESs. Next, we study the problem of asymmetric data delivery in such nanonetworks-based systems and propose a simple distance-aware power allocation algorithm, named catch-the-pendulum, which optimizes the energy consumption of nanoDESs for communicating data from the underlying nanonetworks to radio frequency (RF) based macro-scale communication networks...
October 5, 2016: IEEE Transactions on Nanobioscience
S A Papadimitriou, M P Robin, D Ceric, R K O'Reilly, S Marino, M Resmini
Nanomaterials are emerging as strong candidates for applications in drug delivery and offer an alternative platform to modulate the differentiation and activity of neural stem cells. Herein we report the synthesis and characterization of two different classes of polymeric nanoparticles: N-isopropylacrylamide-based thermoresponsive nanogels RM1 and P(TEGA)-b-P(d,lLA)2 nano-micelles RM2. We covalently linked the nanoparticles with fluorescent tags and demonstrate their ability to be internalized and tracked in neural stem cells from the postnatal subventricular zone, without affecting their proliferation, multipotency and differentiation characteristics up to 150 μg ml(-1)...
October 6, 2016: Nanoscale
Gaurav Chauhan, Vianni Chopra, Amit Tyagi, Goutam Rath, Rakesh K Sharma, Amit K Goyal
Nano-graphene oxide (GO) nanometal composite (specifically nanogold and nanosilver) have shown to be a promising material for anticancer therapeutics. Owing to their high drug loading capacity, photothermal and synergizing effects, it is very important to exploit them for targeted chemo-thermal cancer therapeutics. In this work, gold nanoparticles (AuNPs) were selected as the composite metal, folic acid (FA) was taken as GO surface functionalization moiety for active tumor targeting of model anticancer drug Doxorubicin (Dox)...
October 6, 2016: European Journal of Pharmaceutical Sciences
Serena Mazzucchelli, Alessandro Ravelli, Fausto Gigli, Mauro Minoli, Fabio Corsi, Pierangela Ciuffreda, Roberta Ottria
This study describes the development of simple, rapid and sensitive liquid chromatography tandem mass spectrometry method for the simultaneous analysis of doxorubicin and its major metabolite, doxorubicinol, in mouse plasma, urine and tissues. The calibration curves were linear over the range 5-250 ng/ml for doxorubicin and 1.25-25 ng/ml for doxorubicinol in plasma and tumor, over the range 25-500 ng/ml for doxorubicin and 1.25-25 ng/ml for doxorubicinol in liver and kidney, and over the range 25-1000 ng/ml for doxorubicin and doxorubicinol in urine...
October 7, 2016: Biomedical Chromatography: BMC
Pengfan Gao, Yuqing Wu, Lixin Wu
The synergistic self-assembly of biomolecules with polyoxometalates (POMs) has recently been considered as an effective approach to construct nano-biomaterials with diverse structures and morphologies towards applications in drug delivery, controlled release, tissue engineering scaffolds, and biomineralization, due to the unique features of the clusters in addition to many well-known inorganic nanoparticles. This review presents an overview of recent work focusing on the noncovalent co-assembly of peptides and POMs as well as their biological applications...
October 5, 2016: Soft Matter
Bahareh Kherzi, Martin Pumera
Self-propelled autonomous nano/micromotors are in the forefront of current materials science and technology research. These small machines convert chemical energy from the environment into propulsion, and they can move autonomously in the environment and are capable of chemotaxis or magnetotaxis. They can be used for drug delivery, microsurgeries or environmental remediation. It is of immense interest from a future biomedical application point of view to understand the motion of the nano/micromotors in microfluidic channels...
October 14, 2016: Nanoscale
Fei Xiong, Jilai Tian, Ke Hu, Xiawen Zheng, Jianfei Sun, Caiyun Yan, Juan Yao, Lina Song, Yu Zhang, Ning Gu
Leukemia, unlike solid tumors, has no definite shape and spreads throughout the whole circulatory system, therefore the therapy of leukemia requires medication to stay longer in the circulatory system. Anisotropic nanoparticles, showing longer blood circulating life than that of isotropic nanoparticles reported in previous research, meet the demands of leukemia therapy. Based on this strategy, superparamagnetic anisotropic nano-assemblies (SANs) were fabricated and loaded with vincristine (VCR) to form VCR-SANs...
October 6, 2016: Nanoscale
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