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https://www.readbyqxmd.com/read/28533175/dendrimer-encapsulated-and-conjugated-delivery-of-berberine-a-novel-approach-mitigating-toxicity-and-improving-in-vivo-pharmacokinetics
#1
Lokesh Gupta, Ashok Kumar Sharma, Avinash Gothwal, Mohammed Shahid Khan, Mahaveer Prasad Khinchi, Arem Qayum, Shashank Kumar Singh, Umesh Gupta
Berberine (BBR) is a nitrogenous cyclic natural alkaloid with potential anticancer activity. However it has been less explored due to its poor pharmacokinetic profile. Dendrimers (e.g. PAMAM) have promising potential to deliver anticancer drugs/bio-actives because of their well-defined architecture, monodispersity and tailor-made surface functionality. In the present study it was attempted to deliver berberine through G4 PAMAM dendrimers by conjugation (BPC) as well as encapsulation (BPE) approach. The developed encapsulated and conjugated berberine formulations were found to have size in the approximate range of 100-200nm while zeta potential was almost same as PAMAM G4 dendrimer...
May 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28532112/preparations-and-doxorubicin-controlled-release-of-amino-acid-based-redox-ph-dual-responsive-nanomicelles
#2
Yuanyuan Ding, Liping Zhang, Gang Shi, Xinxin Sang, Caihua Ni
Terpolymers of poly (Lysine-co-N, N-Bis (acryloyl) cystamine-co-β-Phenethylamine) (PLBP) were synthesized in one-pot by Michael addition terpolymerization. The terpolymers self-assembled into nano-sized spherical micelles (84-123nm) with narrow distributions. The surface charge of the nanomicelles (NMs) was depended on solution's pH and showed negative values under physiological conditions (pH7.4), which was beneficial for long circulation without non-specific protein adsorption. Doxorubicin (DOX) was effectively loaded into the NMs for controlled release...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532109/lactoferrin-modified-graphene-oxide-iron-oxide-nanocomposite-for-glioma-targeted-drug-delivery
#3
Meng-Meng Song, Huai-Liang Xu, Jun-Xing Liang, Hui-Hui Xiang, Rui Liu, Yu-Xian Shen
Targeting delivery of drugs in a specific manner represents a potential powerful technology in gliomas. Herein, we prepared a multifunctional targeted delivery system based on graphene oxide (GO) that contains a molecular bio-targeting ligand and superparamagnetic iron oxide nanoparticles on the surface of GO for magnetic targeting. Superparamagnetic Fe3O4 nanoparticles was loaded on the surface of GO via chemical precipitation method to form GO@Fe3O4 nanocomposites. Lactoferrin (Lf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells and vascular endothelial cell of the blood brain barrier, was chosen as the targeted ligand to construct the targeted delivery system Lf@GO@Fe3O4 through EDC/NHS chemistry...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532085/mesoporous-nano-bioglass-designed-for-the-release-of-imatinib-and-in-vitro-inhibitory-effects-on-cancer-cells
#4
Muhammad Shoaib, Aamer Saeed, Muhammad Saif Ur Rahman, Muhammad Moazzam Naseer
For treating bone cancer, controlled drug delivery is an important strategy. Bioactive scaffolds are widely used biomaterials due to their usefulness in localized drug delivery. The aim of this study was to develop mesoporous bioglass (MBG) with improved bioactivity and controllable drug delivery rate. By using pluronic 123 (P123) as a template, a facile sol-gel route was employed for the synthesis of MBG nanoparticles (NPs). The composition of the prepared sample was estimated by using energy dispersive X-ray spectroscopy (EDX)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530539/preparation-optimization-and-physicochemical-characterization-of-aripiprazole-loaded-nano-porous-in-situ-forming-implant
#5
Ashkan Hedayati, Sina Ghafurzadeh Yazdi, Pouya Dehghankelishadi, Nika Bahari Javan, Hamid Akbari, Farid A Dorkoosh
BACKGROUND: Multiple applications of antipsychotic agents are the main obstacle upon treatment of schizophrenia. Due to behavioral abnormalities, low compliance is observed in the most of psychotic patients. Designing of new drug delivery systems to overcome compliance problem seems to be necessary. In situ forming implants are a suitable choice for delivery of antipsychotic agents due to easy administration process and sustained release kinetics. OBJECTIVE: In this study, a novel poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) based nano-porous in situ implant system is developed for delivery of aripiprazole...
May 22, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28530538/qualitative-estimation-of-drug-entrapment-efficiency-in-polymeric-nano-micelles-using-dpd
#6
Farzin Hadizadeh, Jamal Shamsara
BACKGROUND: Dissipative particle dynamics (DPD) is a simulation method that one of its applications is in the field of pharmaceutical science and drug delivery. OBJECTIVE: DPD is employed to study morphology and some other characteristics of polymeric nano-micelles. Two systems were considered in this study: system A which includes curcumin, Polycaprolactone (PCL), Polyethylene glycol (PEG) and water beads and system B which includes paclitaxel, Polylactic acid (PLA), PEG and water beads...
May 22, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28530146/an-emerging-integration-between-ionic-liquids-and-nanotechnology-general-uses-and-future-prospects-in-drug-delivery
#7
Tânia Santos de Almeida, Ana Júlio, Joana Portugal Mota, Patrícia Rijo, Catarina Pinto Reis
There is a growing need to develop drug-delivery systems that overcome drawbacks such as poor drug solubility/loading/release, systemic side effects and limited stability. Ionic liquids (ILs) offer many advantages and their tailoring represents a valuable tuning tool. Nano-based systems are also prized materials that prevent drug degradation, enhance their transport/distribution and extend their release. Consequently, structures containing ILs and nanoparticles (NPs) have been developed to attain synergistic effects...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28524076/-18-f-fluorinated-carboplatin-and-111-in-liposome-for-image-guided-drug-delivery
#8
Narottam Lamichhane, Gajanan K Dewkar, Gobalakrishnan Sundaresan, Rebecca N Mahon, Jamal Zweit
Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of liposomes in real-time, which helps in optimizing the therapeutic efficacy of the liposomal drug delivery. This work utilizes the platform of [(111)In]-Liposome as a drug delivery vehicle, encapsulating a novel (18)F-labeled carboplatin drug derivative ([(18)F]-FCP) as a dual-molecular imaging tool as both a radiolabeled drug and radiolabeled carrier. The approach has the potential for clinical translation in individual patients using a dual modal approach of clinically-relevant radionuclides of (18)F positron emission tomography (PET) and (111)In single photon emission computed tomography (SPECT)...
May 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28524069/helical-plant-viral-nanoparticles-bioinspired-synthesis-of-nanomaterials-and-nanostructures
#9
Kannan Badri Narayanan, Sung Soo Han
Viral nanotechnology is revolutionizing the biomimetic and bioinspired synthesis of novel nanomaterials. Bottom-up nanofabrication by self-assembly of individual molecular components of elongated viral nanoparticles (VNPs) and virus-like particles (VLPs) has resulted in the production of superior materials and structures in the nano(bio)technological fields. Viral capsids are attractive materials, because of their symmetry, monodispersity, and polyvalency. Helical VNPs/VLPs are unique prefabricated nanoscaffolds with large surface area to volume ratios and high aspect ratios, and enable the construction of exquisite supramolecular nanostructures...
May 19, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28521254/cs-peg-decorated-plga-nano-prototype-for-delivery-of-bioactive-compounds-a-novel-approach-for-induction-of-apoptosis-in-hepg2-cell-line
#10
Ahmed A Abd-Rabou, Hanaa H Ahmed
PURPOSE: Polymer-based nanoparticles are used as vectors for cancer drug delivery. The bioactive compounds (quercetin, ellagic acid and gallic acid) are well known to be not only antioxidants but also chemopreventive candidates against various types of cancers. To circumvent the low bioavailability and the short half-life time obstacles, we hypothesized a novel PLGA nano-platform functionalized with CS and PEG to encapsulate these phytochemicals. This encapsulation will protect the compounds from the phagocytic uptake and deliver PLGA-CS-PEG nano-prototype with high biodegradability and biosafety...
March 12, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28516778/surfactant-assemblies-on-selected-nano-structured-surfaces-evidence-driving-forces-and-applications
#11
Alberto Striolo, Brian Patrick Grady
Surfactant adsorption at solid-liquid interfaces is critical for a number of applications of vast industrial interest, and can also be used to seed surface-modification processes. Many of the surfaces of interest are nano-structured, as they might present surface roughness at the molecular scale, chemical heterogeneity, as well as a combination of both surface roughness and chemical heterogeneity. These effects provide 'lateral' confinement on the surfactant aggregates. It is of interest to quantify how much surfactant adsorbs on such nano-structured surfaces, and how the surfactant aggregates vary as the degree of lateral confinement changes...
May 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28513733/polylactic-acid-nano-and-microchamber-arrays-for-encapsulation-of-small-hydrophilic-molecules-featuring-drug-release-via-high-intensity-focused-ultrasound
#12
Meiyu Gai, Johannes Frueh, Tianyi Tao, Arseniy V Petrov, Vladimir V Petrov, Evgeniy V Shesterikov, Sergei I Tverdokhlebov, Gleb B Sukhorukov
Long term encapsulation combined with spatiotemporal release for a precisely defined quantity of small hydrophilic molecules on demand remains a challenge in various fields ranging from medical drug delivery, controlled release of catalysts to industrial anti-corrosion systems. Free-standing individually sealed polylactic acid (PLA) nano- and microchamber arrays were produced by one-step dip-coating a PDMS stamp into PLA solution for 5 s followed by drying under ambient conditions. The wall thickness of these hydrophobic nano-microchambers is tunable from 150 nm to 7 μm by varying the PLA solution concentration...
May 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28513711/a-novel-approach-for-fabricating-highly-tunable-and-fluffy-bioinspired-3d-poly-vinyl-alcohol-pva-fiber-scaffolds
#13
Sunanda Roy, Shreyas Kuddannaya, Tanya Das, Heng Yeong Lee, Jacob Lim, Xiao 'Matthew' Hu, Yue Chee Yoon, Jaehwan Kim
The excellent biocompatibility, biodegradability and chemo-thermal stability of poly(vinyl alcohol) (PVA) have been harnessed in diverse practical applications. These properties have motivated the fabrication of high performance PVA based nanofibers with adequate control over the micro and nano-architectures and surface chemical interactions. However, the high water solubility and hydrophilicity of the PVA polymer limits the application of the electrospun PVA nanofibers in aqueous environments owing to instantaneous dissolution...
May 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28504251/programmable-co-delivery-of-the-immune-checkpoint-inhibitor-nlg919-and-chemotherapeutic-doxorubicin-via-a-redox-responsive-immunostimulatory-polymeric-prodrug-carrier
#14
Jing-Jing Sun, Yi-Chao Chen, Yi-Xian Huang, Wen-Chen Zhao, Yan-Hua Liu, Raman Venkataramanan, Bin-Feng Lu, Song Li
To achieve synergistic therapeutic efficacy and prevent cancer relapse, chemotherapy and immunotherapy have been combined as a new modality for tumor treatment. In this work, we designed a redox-responsive immunostimulatory polymeric prodrug carrier, PSSN10, for programmable co-delivery of an immune checkpoint inhibitor NLG919 (NLG) and a chemotherapeutic doxorubicin (DOX). NLG-containing PSSN10 prodrug polymers were self-assembled into nano-sized micelles that served as a carrier to load DOX (DOX/PSSN10 micelles)...
May 8, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28503951/gold-nanoparticles-applications-from-artificial-enzyme-till-drug-delivery
#15
Kazem Golchin, Jafar Golchin, Shahrooz Ghaderi, Neda Alidadiani, Sajjad Eslamkhah, Masoud Eslamkhah, Soodabeh Davaran, Abolfazl Akbarzadeh
Today, nano-medicine promotes new therapeutics and diagnostics tools, including sensing of biomolecules as a biosensor, cancer chemotherapy and drug or gene delivery. Because of small size and biocompatibility of gold nanoparticles (GNPs), they become a good candidate for biological application. Also, thanks to their biological and chemical properties, they can mimic function of some enzymes including super oxide dismutase (SOD), esterase, etc. Also, biomaterials and bioengineering have grown so fast since the last decade for many therapeutic applications such as tissue regeneration...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28501673/chemotherapeutic-drug-photothermal-agent-co-self-assembling-nanoparticles-for-near-infrared-fluorescence-and-photoacoustic-dual-modal-imaging-guided-chemo-photothermal-synergistic-therapy
#16
Yang Li, Guihua Liu, Jinyuan Ma, Jinyan Lin, Huirong Lin, Guanghao Su, Dengyue Chen, Shefang Ye, Xiaoyuan Chen, Xuan Zhu, Zhenqing Hou
Multimodal imaging-guided synergistic combination therapy has shown great potential for cancer treatment. However, the nanocarrier-based theranostic systems suffer from batch-to-batch variation, complexity of multicomponent, poor drug loading, and carrier-related toxicity issues. To address these issues, herein we developed a novel carrier-free theranostic system with nanoscale characteristics for near-infrared fluorescence (NIRF) and photoacoustic (PA) dual-modal imaging-guided synergistic chemo-photothermal therapy (PTT)...
May 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28500326/intranasal-drug-delivery-of-small-interfering-rna-targeting-beclin1-encapsulated-with-polyethylenimine-pei-in-mouse-brain-to-achieve-hiv-attenuation
#17
Myosotys Rodriguez, Jessica Lapierre, Chet Raj Ojha, Ajeet Kaushik, Elena Batrakova, Fatah Kashanchi, Seth M Dever, Madhavan Nair, Nazira El-Hage
We previously reported that activation of the host autophagic protein, Beclin1, by HIV-1 infection represents an essential mechanism in controlling HIV replication and viral-induced inflammatory responses in microglial cells. Existing antiretroviral therapeutic approaches have been limited in their ability to cross the blood-brain barrier effectively and recognize and selectively eliminate persistent HIV-infected brain reservoirs. In the present study and for the first time, the bio-distribution and efficacy of noninvasive intranasal delivery of small interfering RNA (siRNA) against the Beclin1 gene using the cationic linear polyethylenimines (PEI) as a gene carrier was investigated in adult mouse brain...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28499602/from-polyelectrolyte-complexes-to-polyelectrolyte-multilayers-electrostatic-assembly-nanostructure-dynamics-and-functional-properties
#18
Biswa P Das, Marina Tsianou
Polyelectrolyte complexes (PECs) are three-dimensional macromolecular structures formed by association of oppositely charged polyelectrolytes in solution. Polyelectrolyte multilayers (PEMs) can be considered a special case of PECs prepared by layer-by-layer (LbL) assembly that involves sequential deposition of molecular-thick polyelectrolyte layers with nanoscale control over the size, shape, composition and internal organization. Although many functional PEMs with novel physical and chemical characteristics have been developed, the current practical applications of PEMs are limited to those that require only a few bilayers and are relatively easy to prepare...
December 16, 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28499164/mechanical-properties-and-antibiotic-release-characteristics-of-poly-methyl-methacrylate-based-bone-cement-formulated-with-mesoporous-silica-nanoparticles
#19
Kumaran Letchmanan, Shou-Cang Shen, Wai Kiong Ng, Poddar Kingshuk, Zhilong Shi, Wilson Wang, Reginald B H Tan
The influence of mesoporous silica nanoparticles (MSNs) loaded with antibiotics on the mechanical properties of functional poly(methyl methacrylate)-(PMMA) based bone cements is investigated. The incorporation of MSNs to the bone cements (8.15wt%) shows no detrimental effects on the biomechanical properties of the freshly solidified bone cements. Importantly, there are no significant changes in the compression strength and bending modulus up to 6 months of aging in PBS buffer solution. The preserved mechanical properties of MSN-functionalized bone cements is attributed to the unchanged microstructures of the cements, as more than 96% of MSNs remains in the bone cement matrix to support the cement structures after 6 months of aging...
May 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28494736/smart-micro-nano-robotic-systems-for-gene-delivery
#20
Alireza Pedram, Hossein Nejat Pishkenari
Small scale robotics have attracted growing attention for the prospect of targeting and accessing cell-sized sites, necessary for high precision biomedical applications and drug/gene delivery. The loss of controlled gene therapy, inducing systemic side effects and reduced therapeutic efficiency, can be settled utilizing these intelligent carriers. Newly proposed solutions for the main challenges of control, power supplying, gene release and final carrier extraction/degradation have shifted these smart miniature robots to the point of being employed for practical applications of transferring oligonucleotides (pDNA, siRNA, mRNA, etc...
May 10, 2017: Current Gene Therapy
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