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https://www.readbyqxmd.com/read/28429875/effect-of-untreated-zirconium-oxide-nanofiller-on-the-flexural-strength-and-surface-hardness-of-autopolymerized-interim-fixed-restoration-resins
#1
Abdolhamid Alhavaz, Maryam Rezaei Dastjerdi, Arman Ghasemi, Azade Ghasemi, Abolfazl Alizadeh Sahraei
OBJECTIVE: Autopolymerized poly methyl methacrylate (PMMA) resin is commonly used for the construction of interim restorations; however, it has less than optimal mechanical properties. In this article, we evaluated the reinforcing effect of adding untreated zirconia nanoparticles on the flexural strength and surface hardness of this resin. METHODS: A total of 80 specimens were fabricated. Forty each were used for the flexural strength test and for the surface hardness test...
April 21, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28428086/evaluation-of-garlic-oil-in-nano-emulsified-form-optimization-and-its-efficacy-in-high-fat-diet-induced-dyslipidemia-in-wistar-rats
#2
Ragavan Gokulakannan, Muralidaran Yuvashree, Sridharan Badrinathan, Nachiappa Ganesh Rajesh, Pragasam Viswanathan
Garlic oil nanoemulsion was formulated using ultrasonic emulsification and the optimized garlic oil nanoemulsion ratio (1:2) of oil: surfactant showed spherical, with tiny droplet size 24.9 ± 1.11 nm. It was observed that the prepared nanoemulsion has the zeta potential of -42.63 ± 1.58 mV and a low polydispersity index of 0.2 ± 0.09 with excellent stability. The formulation was subjected to in vivo acute and sub-acute toxicity. In acute toxicity study, single oral administration of 18.63 ml of garlic oil nanoemulsion/kg resulted in immediate mortality...
April 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28427443/benserazide-a-dopadecarboxylase-inhibitor-suppresses-tumor-growth-by-targeting-hexokinase-2
#3
Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min, Weiguang Sun, Lixia Chen, Guangya Xiang, Hua Li
BACKGROUND: Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. HK2 plays a pivotal role in tumor initiation and maintenance, which provides a new target for cancer therapy. METHODS: Structure-based virtual ligand screening was used in hit identification from ZINC Drug Database. Microscale thermophoresis assay was performed to evaluate the binding affinity...
April 20, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28426935/manipulation-of-mg2-ca2-switch-on-the-development-of-bone-mimetic-hydroxyapatite
#4
Nancy C Andrés, Noelia L D'Elía, Juan M Ruso, Adrián Esteban Campelo, Virginia L Massheimer, Paula V Messina
Ionic substitution can affect essential physicochemical properties leading to a specific biological behavior upon implantation. Therefore it has been proposed as a tool to increase the biological efficiency of calcium phosphate based materials. In the following study we have evaluated the contribution of an important cation in nature, Mg2+, into the structure of previously studied biocompatible and biodegradable hydroxyapatite (HA) nano-rods and its subsequent effect on its chemical, morphology and bone mimetic articulation...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28419442/characterization-of-runx2-phosphorylation-sites-required-for-tgf-%C3%AE-1-mediated-stimulation-of-matrix-metalloproteinase-13-expression-in-osteoblastic-cells
#5
B Arumugam, M Vairamani, N C Partridge, N Selvamurugan
Transforming growth factor-beta1 (TGF-β1), a highly abundant growth factor in skeletal tissues, stimulates matrix metalloproteinase-13 (MMP-13) expression in osteoblastic cells. MMP-13 plays a critical role in bone remodeling. Runx2, a bone transcription factor, is required for TGF-β1-mediated stimulation of MMP-13 expression in osteoblastic cells. In this study, the molecular mechanism responsible for TGF-β1-stimulation of MMP-13 expression via Runx2 in osteoblastic cells was elucidated. TGF-β1 stimulated the phosphorylation of Runx2 at serine amino acids, and ERK inhibition blocked this effect in rat (UMR106-01) and human (MG-63) osteoblastic cells...
April 17, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28417924/novel-nano-therapeutic-approach-actively-targets-human-ovarian-cancer-stem-cells-after-xenograft-into-nude-mice
#6
Amoura Abou-ElNaga, Ghada Mutawa, Ibrahim M El-Sherbiny, Hassan Abd-ElGhaffar, Ahmed A Allam, Jamaan Ajarem, Shaker A Mousa
The power of tumorigenesis, chemo-resistance and metastasis in malignant ovarian tumors resides in a tiny population of cancer cells known as ovarian cancer stem cells (OCSCs). Developing nano-therapeutic targeting of OCSCs is considered a great challenge. The potential use of poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) was investigated as a drug delivery system for paclitaxel (PTX) against OCSCs in vitro and in vivo. PTX-loaded PLGA NPs were prepared by an emulsion solvent evaporation method, supported by incorporation of folic acid (FA) as the ligand...
April 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28415542/bladder-smooth-muscle-cells-on-electrospun-poly-%C3%AE%C2%B5-caprolactone-poly-l-lactic-acid-scaffold-promote-bladder-regeneration-in-a-canine-model
#7
Nasser Shakhssalim, Masoud Soleimani, Mohammad M Dehghan, Javad Rasouli, Masoud Taghizadeh-Jahed, Peyman M Torbati, Mohammad Naji
Engineering of urinary bladder has been the focus of numerous studies in recent decade. Novel biomaterials, innovative fabrication methods and various modification processes of scaffolds are the critical issues to find supportive matrices. Supportive characteristics of electrospun PCL/PLLA nano-scaffold for bladder augmentation in canine model and the role of bladder cells in regeneration process were appraised. Electrospun PCL/PLLA was fabricated by co-electrospinning of PCL and PLLA. Bladder cells were isolated and transduced with lentiviral particles encoding eGFP and JRed proteins...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415386/modification-and-evaluation-of-micro-nano-structured-porous-bacterial-cellulose-scaffold-for-bone-tissue-engineering
#8
Yan Huang, Jing Wang, Fei Yang, Yingnan Shao, Xiaoling Zhang, Kerong Dai
No abstract text is available yet for this article.
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413588/relative-biocompatibility-of-micro-hybrid-and-nano-hybrid-light-activated-composite-resins
#9
Abiodun Olabisi Arigbede, Bukola Folasade Adeyemi, Omowumi Femi-Akinlosotu
Background. In vitro studies have revealed a direct association between resin content and cytotoxicity of composite resins; however, implantation studies in this regard are sparse. This study investigates the relationship between filler content of composite resins and biocompatibility. Methods. This research employed twelve 180‒200-gr male Wistar rats, 1 nano-hybrid (Prime-Dent Inc.) and 1 micro-hybrid (Medental Inc.) composite resins containing 74% and 80‒90% filler content, respectively. The samples were assessed on the 2nd, 14th and 90th day of implantation...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28412552/copper-containing-mesoporous-bioactive-glass-nanoparticles-as-multifunctional-agent-for-bone-regeneration
#10
Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giogia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M González-Calbet, Livia Visai, Chiara Vitale-Brovarone
The application of mesoporous bioactive glasses (MBGs) containing controllable amount of different ions, with the aim to impart antibacterial activity, as well as stimulation of osteogenesis and angiogenesis, is attracting an increasing interest. In this contribution, in order to endow nano-sized MBG with additional biological functions, the framework of a binary SiO2-CaO mesoporous glass was modified with different concentrations of copper ions (2 and 5% mol.), through a one-pot ultrasound-assisted sol-gel procedure...
April 12, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28412451/laser-treated-electrospun-fibers-loaded-with-nano-hydroxyapatite-for-bone-tissue-engineering
#11
Javier Aragon, Nuria Navascues, Gracia Mendoza, Silvia Irusta
Core-shell polycaprolactone/polycaprolactone (PCL/PCL) and polycaprolactone/polyvinyl acetate (PCL/PVAc) electrospun fibers loaded with synthesized nanohydroxyapatite (HAn) were lased treated to create microporosity. The prepared materials were characterized by XRD, FTIR, TEM and SEM. Uniform and randomly oriented beadless fibrous structures were obtained in all cases. Fibers diameters were in the 150-300nm range. Needle-like HAn nanoparticles with mean diameters of 20nm and length of approximately 150nm were mostly encase inside the fibers...
April 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28409821/nano-curcumin-safely-prevents-streptozotocin-induced-inflammation-and-apoptosis-in-pancreatic-%C3%A3-cells-for-effective-management-of-type-1-diabetes-mellitus
#12
Raghu Ganugula, Meenakshi Arora, Patcharawalai Jaisamut, Ruedeekorn Wiwattanapatapee, Heather G Jørgensen, Vinod P Venkatpurwar, Beiyan Zhou, Aline Rodrigues Hoffmann, Rita Basu, Shaodong Guo, Majeti N V Ravi Kumar
BACKGROUND AND PURPOSE: Approaches to prevent selective and progressive loss of insulin-producing ß-cells in Type 1 diabetes mellitus (T1DM) will help conquer this prevalent and devastating disease. Curcumin (CUR), a natural anti-inflammatory, suppresses diabetes associated inflammation and cell death. However, very high doses have been tested owing to poor oral bioavailability, making it difficult to translate to the clinic. EXPERIMENTAL APPROACH: We recently prepared biodegradable nanosystems encapsulating curcumin (nCUR), resulting in at least 9-fold improvement in oral bioavailability...
April 13, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28404947/identification-of-urine-biomarkers-associated-with-lung-adenocarcinoma
#13
Weiwei Wang, Shanshan Wang, Man Zhang
Lung adenocarcinoma (LAC) progression is accompanied by changes in protein levels that may be reflected in body fluids, such as urine. Urine collected from LAC patients (n=34) and healthy controls (n=36) was analyzed via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) combined with weak cationic exchange magnetic beads. The results revealed 76 urinary polypeptides significantly different between LAC patients and normal controls (P<0.05). Twenty-two of these peptides were up-regulated and 54 were down-regulated...
March 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402842/dendrimer-functional-hydroxyapatite-nanoparticles-generated-by-functionalization-with-siloxane-cored-pamam-dendrons
#14
Merve Huysal, Mehmet Şenel
The surface modification of nano-hydroxyapatite with polyamidoamine (PAMAM) dendrimer has potential for biomedical applications due to their unique and well-defined secondary structures. This paper presents a facile method to synthesize siloxane-cored PAMAM dendrons modified Hydroxyapatite nanoparticles. Firstly, the siloxane-cored PAMAM dendrons with different generations (G1 to G5, respectively) were synthesized using repetitive reactions between Michael addition and amidation starting from 3-aminopropyltriethoxysilane...
April 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28402219/modified-n-ha-pa66-scaffolds-with-chitosan-coating-for-bone-tissue-engineering-cell-stimulation-and-drug-release
#15
Qin Zou, Junfeng Li, Lulu Niu, Yi Zuo, Jidong Li, Yubao Li
The dipping-drying procedure and cross-linking method were used to make drug-loaded chitosan(CS) coating on nano-hydroxyapatite/polyamide66 (nHA/PA66) composite porous scaffold, endowing the scaffold controlled drug release functionality. The prefabricated scaffold was immersed into an aqueous drug/CS solution in a vacuum condition and then crosslinked by vanillin. The structure, porosity, composition, compressive strength, swelling ratio, drug release and cytocompatibility of the pristine and coating scaffolds were investigated...
April 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28398005/nanotherapy-for-duchenne-muscular-dystrophy
#16
REVIEW
Michael E Nance, Chady H Hakim, N Nora Yang, Dongsheng Duan
Duchenne muscular dystrophy (DMD) is a lethal X-linked childhood muscle wasting disease caused by mutations in the dystrophin gene. Nanobiotechnology-based therapies (such as synthetic nanoparticles and naturally existing viral and nonviral nanoparticles) hold great promise to replace and repair the mutated dystrophin gene and significantly change the disease course. While a majority of DMD nanotherapies are still in early preclinical development, several [such as adeno-associated virus (AAV)-mediated systemic micro-dystrophin gene therapy] are advancing for phase I clinical trials...
April 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28387652/pediatric-ependymoma-a-proteomics-perspective
#17
George Th Tsangaris, Chrissa Papathanasiou, Panagiotis G Adamopoulos, Andreas Scorilas, Constantinos E Vorgias, Neofytos Prodromou, Foteini Tzortzatou Stathopoulou, Dimitrios J Stravopodis, Athanasios K Anagnostopoulos
BACKGROUND/AIM: Proteomics based on high-resolution mass spectrometry (MS) is the tool of choice for the analysis of protein presence, modifications and interactions, with increasing emphasis on the examination of tumor tissues. Application of MS-based proteomics offers a detailed picture of tumor tissue characteristics, facilitating the appreciation of different tumor entities, whilst providing reliable and fast results for therapeutic marker targeting and prognostic factor assessment...
March 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28384646/enhanced-thermal-effect-using-magnetic-nano-particles-during-high-intensity-focused-ultrasound
#18
Surendra Balaji Devarakonda, Matthew R Myers, Dushyanth Giridhar, Seyed Ahmad Reza Dibaji, Rupak Kumar Banerjee
Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5...
2017: PloS One
https://www.readbyqxmd.com/read/28383528/the-effect-of-the-serum-corona-on-interactions-between-a-single-nano-object-and-a-living-cell
#19
Yael Dror, Raya Sorkin, Guy Brand, Olga Boubriak, Jill Urban, Jacob Klein
Nanoparticles (NPs) which enter physiological fluids are rapidly coated by proteins, forming a so-called corona which may strongly modify their interaction with tissues and cells relative to the bare NPs. In this work the interactions between a living cell and a nano-object, and in particular the effect on this of the adsorption of serum proteins, are directly examined by measuring the forces arising as an Atomic Force Microscope tip (diameter 20 nm) - simulating a nano-object - approaches and contacts a cell...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376367/injectable-nanofibrous-spongy-microspheres-for-nr4a1-plasmid-dna-transfection-to-reverse-fibrotic-degeneration-and-support-disc-regeneration
#20
Ganjun Feng, Zhanpeng Zhang, Ming Dang, Xiaojin Zhang, Yasmine Doleyres, Yueming Song, Di Chen, Peter X Ma
Safe and efficient gene therapy is highly desired for controlling pathogenic fibrosis of nucleus pulposus (NP) tissue, which would result in intervertebral disc (IVD) degeneration and disability if left untreated. In this work, a hyperbranched polymer (HP) with high plasmid DNA (pDNA) binding affinity and negligible cytotoxicity is synthesized, which can self-assemble into nano-sized polyplexes with a "double shell" structure that can transfect pDNA into NP cells with very high efficiency. These polyplexes are then encapsulated in biodegradable nanospheres (NS) to enable two-stage delivery: 1) temporally-controlled release of pDNA-carrying polyplexes and 2) highly efficient delivery of pDNA into cells by the released polyplexes...
March 24, 2017: Biomaterials
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