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https://www.readbyqxmd.com/read/28330282/in-vitro-cytotoxicity-and-antibacterial-activity-of-silver-coated-electrospun-polycaprolactone-gelatine-nanofibrous-scaffolds
#1
Mim Mim Lim, Naznin Sultana
The development of nano-sized scaffolds with antibacterial properties that mimic the architecture of tissue is one of the challenges in tissue engineering. In this study, polycaprolactone (PCL) and PCL/gelatine (Ge) (70:30) nanofibrous scaffolds were fabricated using a less toxic and common solvent, formic acid and an electrospinning technique. Nanofibrous scaffolds were coated with silver (Ag) in different concentrations of silver nitrate (AgNO3) aqueous solution (1.25, 2.5, 5, and 10 %) by using dipping method, drying and followed by ultraviolet (UV) photoreduction...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327694/safety-and-efficacy-of-a-biomimetic-monolayer-of-permanently-bound-multiphosphonic-acid-molecules-on-dental-implants-3-years-post-loading-results-from-a-pilot-quadruple-blinded-randomised-controlled-trial
#2
Marco Esposito, Ivan Dojcinovic, Sabrina Buchini, Péter Péchy, Björn-Owe Aronsson
PURPOSE: To evaluate the safety and clinical efficacy of a novel surface treatment (SurfLink, Nano Bridging Molecules, Gland, Switzerland) on titanium dental implants. SurfLink consists of a monolayer of permanently bound multiphosphonic acid molecules, which mimics the surface of naturally occurring hydroxyapatite. MATERIALS AND METHODS: Twenty-three patients requiring at least two single dental implants had their sites randomised according to a split-mouth design to receive one titanium grade 4 implant treated with SurfLink and one untreated control implant...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28326340/organ-and-tissue-level-properties-are-more-sensitive-to-age-than-osteocyte-lacunar-characteristics-in-rat-cortical-bone
#3
Nina Kølln Wittig, Fiona Linnea Bach-Gansmo, Mie Elholm Birkbak, Malene Laugesen, Annemarie Brüel, Jesper Skovhus Thomsen, Henrik Birkedal
Modeling and remodeling induce significant changes of bone structure and mechanical properties with age. Therefore, it is important to gain knowledge of the processes taking place in bone over time. The rat is a widely used animal model, where much data has been accumulated on age-related changes of bone on the organ and tissue level, whereas features on the nano- and micrometer scale are much less explored. We investigated the age-related development of organ and tissue level bone properties such as bone volume, bone mineral density, and load to fracture and correlated these with osteocyte lacunar properties in rat cortical bone...
June 2016: Bone Reports
https://www.readbyqxmd.com/read/28325318/preparation-and-characterization-of-amine-functional-nano-hydroxyapatite-chitosan-bionanocomposite-for-bone-tissue-engineering-applications
#4
Besir Hakan Atak, Berna Buyuk, Merve Huysal, Sevim Isik, Mehmet Senel, Wolfgang Metzger, Guven Cetin
In this study, three different types of scaffolds including a uniquely modified composite scaffold - namely chitosan (CTS), nano-hydroxyapatite/chitosan composite (CTS+nHAP), and amine group (NH2) modified nano-hydroxyapatite/chitosan composite (CTS+nHAP-NH2) scaffolds - were synthesized for bone tissue engineering (BTE) purposes. As results of the study, it was found that all scaffold types were biodegradable with CTS and CTS+nHAP scaffolds losing up to 15% of their initial weight, while the CTS+nHAP-NH2 scaffold showing 10% of weight loss after six weeks of lysozyme treatment...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28324866/long-term-bioavailability-of-redox-nanoparticles-effectively-reduces-organ-dysfunctions-and-death-in-whole-body-irradiated-mice
#5
Chitho P Feliciano, Koji Tsuboi, Kenshi Suzuki, Hiroyuki Kimura, Yukio Nagasaki
Radioprotective agents have been developed to protect patients against the damaging and lethal effects of ionizing radiation. However, in addition to the intrinsic ability to target reactive oxygen species (ROS), the ability to retain a significant level of bioavailability is desirable in radioprotective agents because that would increase and prolong their radioprotective efficacy and improve its safety. Here, we report the development of a novel nanoparticle-based radioprotective agent with improved bioavailability, which suppressed the adverse effects typically associated with low-molecular-weight (LMW) antioxidants...
March 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28324723/specific-light-up-pullulan-based-nanoparticles-with-reduction-triggered-emission-and-activatable-photoactivity-for-the-imaging-and-photodynamic-killing-of-cancer-cells
#6
Jing Xia, Liuwei Zhang, Ming Qian, Yongming Bao, Jingyun Wang, Yachen Li
Activatable photosensitizers that can be activated by cancer-associated stimuli have drawn increasing attention for simultaneous fluorescence imaging and photodynamic ablation of cancer cells. Here, we developed a cancer-cell specific photosensitizer nano-delivery system by synthesizing protoporphyrin IX (PpIX)-conjugated pullulan (P) with reducible disulfide bonds. The amphiphilic P-s-s-PpIX conjugate self-assembled in aqueous condition to form core-shell structured nanoparticles (P-s-s-PpIX NPs) with average size of 166nm, showing reduction-controllable stability...
March 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28324629/electrospun-nerve-guide-scaffold-of-poly-%C3%AE%C2%B5-caprolactone-collagen-nano-bioglass-an-in-vitro-study-in-peripheral-nerve-tissue-engineering
#7
Forouzan Mohamadi, Somayeh Ebrahimi-Barough, Mohammad Reza Nourani, Mohammad Ali Derakhshan, Vahabodin Goodarzi, Mohammad Sadegh Nazockdast, Mehdi Farokhi, Roksana Tajerian, Reza Faridi Majidi, Jafar Ai
In among of various methods, nerve tissue engineering (NTE) is one of the applicable methods to reconstruct damaged nerve tissues. Electrospinning technique and biomaterials are often considered to fabricate fibrous tissue engineered conduits which have great similarity to the extracellular matrix on fiber structure. Polymer blending is one of the most effective methods for production of new materials with outstanding features. In this research, conduit structures as main part of the peripheral nerve regeneration based on polymer blend nanocomposites PCL/Collagen/NBG (poly (ε-caprolactone)/Collagen/nano bioglass) were manufactured by electrospinning technique...
March 21, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28321876/effects-of-glucose-concentration-on-osteogenic-differentiation-of-type-ii-diabetes-mellitus-rat-bone-marrow-derived-mesenchymal-stromal-cells-on-a-nano-scale-modified-titanium
#8
I Yamawaki, Y Taguchi, S Komasa, A Tanaka, M Umeda
BACKGROUND AND OBJECTIVE: Diabetes mellitus (DM) is a common disease worldwide. Patients with DM have an increased risk of losing their teeth compared with other individuals. Dental implants are a standard of care for treating partial or full edentulism, and various implant surface treatments have recently been developed to increase dental implant stability. However, some studies have reported that DM reduces osseointegration and the success rate of dental implants. The purpose of this study was to determine the effects of high glucose levels for hard tissue formation on a nano-scale modified titanium surface...
March 21, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28321783/biological-and-mechanical-effects-of-micro-nanostructured-titanium-surface-on-an-osteoblastic-cell-line-in-vitro-and-osteointegration-in-vivo
#9
Jingzu Hao, Ying Li, Baoe Li, Xiaolin Wang, Haipeng Li, Shimin Liu, Chunyong Liang, Hongshui Wang
Hybrid micro-nanostructure implant surface was produced on titanium (Ti) surface by acid etching and anodic oxidation to improve the biological and mechanical properties. The biological properties of the micro-nanostructure were investigated by simulated body fluid (SBF) soaking test and MC3T3-E1 cell co-culture experiment. The cell proliferation, spreading, and bone sialoprotein (BSP) gene expression were examined by MTT, SEM, and reverse transcription-polymerase chain reaction (RT-PCR), respectively. In addition, the mechanical properties were evaluated by instrumented nanoindentation test and friction-wear test...
March 20, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28315912/an-imaging-target-tgf-%C3%AE-1-for-hepatocellular-carcinoma-in-mice
#10
Yiqiu Zhang, Beilei Li, Xiao Li, Hui Tan, Dengfeng Cheng, Hongcheng Shi
It has been reported that the positive detection rate of Fluorine-18-fluorodeoxyglucose ((18)F-FDG) metabolism in positron emission tomography (PET) imaging, for the diagnosis of hepatocellular carcinoma (HCC) is only about 50%. In particular, (18)F-FDG PET imaging is prone to false negative findings in HCC. Transforming growth factor-beta1 (TGF-β1) shows over expression rates in early HCC liver tissue growth and promotes tumor invasion and metastases. Our aim was to use In this study, we used the feasibility of iodine-125 ((125)I)-labeled TGF-β1 antibody as a nuclear medicine imaging target in HCC...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28304060/bio-inspired-hybrid-nanoparticles-promote-vascularized-bone-regeneration-in-a-morphology-dependent-manner
#11
Gaojie Yang, Haoming Liu, Xixi Hu, Zetao Chen, Thor E Friis, Jianglin Wang, Yin Xiao, Shengmin Zhang
Current major obstacles for translating the nanoparticle (NP) morphology-related function into therapeutic purposes come from the challenges in understanding the mechanisms that determine cell lineage commitment and constructing a NP-based 3D functional structure, and few studies have successfully demonstrated clear evidence of regulating in vivo tissue regeneration by NP morphology so far. Here, we show that nanoparticle geometry can be harnessed to mediate bone regeneration in a rat cranial defect model. We successfully synthesized hydroxyapatite NPs with well-defined morphologies using a modified liquid-solution-solid (LSS) method...
March 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28303966/targeted-delivery-of-doxorubicin-by-nano-loaded-mesenchymal-stem-cells-for-lung-melanoma-metastases-therapy
#12
Yuekui Zhao, Shanshan Tang, Jiamin Guo, Murad Alahdal, Shunxiu Cao, Zhaocong Yang, Fangfang Zhang, Yumeng Shen, Minjie Sun, Ran Mo, Li Zong, Liang Jin
Poor antigenic presentation of tumor tissues and a lack of specific targets currently limit the success of nanoparticle delivery system. Cellular carrier technique has been recently explored extensively as a substitutive or supplement for traditional targeting delivery system. Here, we demonstrate the usage of mesenchymal stem cells (MSCs) loaded with doxorubicin containing polymer nanoparticles in pulmonary melanoma metastases therapy, as a modified technique of targeted delivery system. The characterizations of prepared nanoparticles and MSCs sensitivity to DOX and PLGA-DOX were measured...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302485/novel-calcified-gum-arabic-porous-nano-composite-scaffold-for-bone-tissue-regeneration
#13
M Hadavi, S Hasannia, Sh Faghihi, F Mashayekhi, H H Zadeh, S B Mostofi
The aim of this study was to investigate the biomechanical and biological properties of a nanocomposite scaffold containing both mineral and polysaccharide constituents. Hydroxyapatite nanoparticles (n-HA) was synthesized from dead abra ovata shells using wet chemical methods and was used in different ratios in concert with gum Arabic, a branched plant polysaccharide. N-HA/gum nanocomposite was fabricated with freeze-drying process and characterized by FTIR and SEM for chemical structure and morphology. Porosity was estimated using liquid substitution method...
March 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28301384/the-effects-of-hierarchical-micro-nano-structured-titanium-surface-on-osteoblast-proliferation-and-differentiation-under-diabetic-conditions
#14
Huanhuan Jiang, Xiang Ma, Wenjuan Zhou, Kai Dong, Xiaohui Rausch-Fan, Shutai Liu, Shu Li
PURPOSE: The aim of the present study was to mimic the hierarchical structure of bone tissues by simple sandblasting/acid-etching and anodization to investigate the effects of such surface characteristics on proliferation and differentiation of osteoblasts in high glucose concentrations. By the way, the effects of high glucose levels on osteoblast functions were tested. METHODS: MC3T3-E1 cells cultured on sand-blasted and acid-etched (SLA) surface and nano-modified SLA (NMSLA) surface were subjected to normal serum (NS) and diabetic serum (DS), respectively...
April 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28301131/bio-inspired-nano-featured-substrates-suitable-environment-for-bone-regeneration
#15
Hassan Rammal, Marie Dubus, Léa Aubert, Fany Reffuveille, Dominique Laurent Maquin, Christine Terryn, Pierre Schaaf, Halima Alem, Grégory Francius, Fabienne Quilès, Sophie C Gangloff, Fouzia Boulmedais, Halima Kerdjoudj
Bone mimicking coatings provide a complex microenvironment in which material, through its inherent properties (such as nanostructure and composition), affects the commitment of stem cells into bone lineage and the production of bone tissue regulating factors, required for bone healing and regeneration. Herein, a bioactive mineral/biopolymers composite made of calcium phosphate/chitosan and hyaluronic acid (CaP-CHI-HA) was elaborated using a versatile simultaneous spray coating of interacting species. The resulting CaP-CHI-HA coating was mainly constituted of bioactive, carbonated and crystalline hydroxyapatite, with 277 ± 98 nm of roughness, 1 μm of thickness and 2...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28300393/remote-control-and-modulation-of-cellular-events-by-plasmonic-gold-nanoparticles-implications-and-opportunities-for-biomedical-applications
#16
Jiayang Li, Jing Liu, Chunying Chen
Compared to traditional hyperthermia methods, gold nanoparticles (Au NPs) successfully achieve site-specific incremental temperature in deep tissues. By virtue of near-infrared (NIR) laser-mediated photothermal treatment, Au NPs have been widely explored in clinical and preclinical applications, including cancer therapy and tissue engineering. In this issue of ACS Nano, Suzuki, Ciofani, and colleagues demonstrate how gold nanoshells can remotely activate striated muscle cells via inducing myotube contraction and modulating related gene expression by mild heat stimulation under NIR irradiation...
March 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28300204/non-invasive-aerosol-delivery-and-transport-of-gold-nanoparticles-to-the-brain
#17
Ramesh Raliya, Debajit Saha, Tandeep S Chadha, Baranidharan Raman, Pratim Biswas
Targeted delivery of nanoscale carriers containing packaged payloads to the central nervous system has potential use in many diagnostic and therapeutic applications. Moreover, understanding of the bio-interactions of the engineered nanoparticles used for tissue-specific delivery by non-invasive delivery approaches are also of paramount interest. Here, we have examined this issue systematically in a relatively simple invertebrate model using insects. We synthesized 5 nm, positively charged gold nanoparticles (AuNPs) and targeted their delivery using the electrospray aerosol generator...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298297/angiogenic-mechanisms-of-human-cd34-stem-cell-exosomes-in-the-repair-of-ischemic-hindlimb
#18
Prabhu Mathiyalagan, Yaxuan Liang, David Kim, Sol Misener, Tina Thorne, Christine Kamide, Ekaterina Klyachko, Douglas W Losordo, Roger J Hajjar, Susmita Sahoo
Rationale: Paracrine secretions appear to mediate therapeutic effects of human CD34(+) stem cells locally transplanted in patients with myocardial and critical limb ischemia as well as in animal models. Earlier, we had discovered that paracrine secretion from human CD34(+) cells contains pro-angiogenic, membrane-bound nano-vesicles called exosomes (CD34Exo). Objective: Here, we investigated the mechanisms of CD34Exo-mediated ischemic tissue repair and therapeutic angiogenesis by studying their miRNA content and uptake...
March 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28290734/quantitative-biokinetics-of-titanium-dioxide-nanoparticles-after-oral-application-in-rats-part-2
#19
Wolfgang G Kreyling, Uwe Holzwarth, Carsten Schleh, Ján Kozempel, Alexander Wenk, Nadine Haberl, Stephanie Hirn, Martin Schäffler, Jens Lipka, Manuela Semmler-Behnke, Neil Gibson
The biokinetics of a size-selected fraction (70nm median size) of commercially available and (48)V-radiolabeled [(48)V]TiO2 nanoparticles has been investigated in female Wistar-Kyoto rats at retention timepoints 1h, 4h, 24h and 7days after oral application of a single dose of an aqueous [(48)V]TiO2-nanoparticle suspension by intra-esophageal instillation. A completely balanced quantitative body clearance and biokinetics in all organs and tissues was obtained by applying typical [(48)V]TiO2-nanoparticle doses in the range of 30-80 μg•kg(-1) bodyweight, making use of the high sensitivity of the radiotracer technique...
March 14, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28287747/assessment-of-gold-nano-particle-mediated-enhanced-hyperthermia-using-mr-guided-high-intensity-focused-ultrasound-ablation-procedure
#20
Surendra Balaji Devarakonda, Matthew R Myers, Matthew Lanier, Charles Dumoulin, Rupak Kumar Banerjee
High-intensity focused ultrasound (HIFU) has gained increasing popularity as a non-invasive therapeutic procedure to treat solid tumors. However, collateral damage due to the use of high acoustic powers during HIFU procedures remains a challenge. The objective of this study is to assess the utility of using gold nano-particles (gNPs) during HIFU procedures to locally enhance heating at low powers, thereby reducing the likelihood of collateral damage. Phantoms containing tissue-mimicking material (TMM) and physiologically relevant concentrations (0%, 0...
March 13, 2017: Nano Letters
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