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https://www.readbyqxmd.com/read/29656601/culture-independent-analysis-of-hydrocarbonoclastic-bacterial-communities-in-environmental-samples-during-oil-bioremediation
#1
Narjes Dashti, Nedaa Ali, Samar Salamah, Majida Khanafer, Ghada Al-Shamy, Husain Al-Awadhi, Samir S Radwan
To analyze microbial communities in environmental samples, this study combined Denaturing Gradient Gel Electrophoresis of amplified 16S rRNA-genes in total genomic DNA extracts from those samples with gene sequencing. The environmental samples studied were oily seawater and soil samples, that had been bioaugmented with natural materials rich in hydrocarbonoclastic bacteria. This molecular approach revealed much more diverse bacterial taxa than the culture-dependent method we had used in an earlier study for the analysis of the same samples...
April 15, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29589261/skeletal-muscle-overexpression-of-short-isoform-sirt3-altered-mitochondrial-cardiolipin-content-and-fatty-acid-composition
#2
Béatrice Chabi, Gilles Fouret, Jérome Lecomte, Fabienne Cortade, Laurence Pessemesse, Narjès Baati, Charles Coudray, Ligen Lin, Qiang Tong, Chantal Wrutniak-Cabello, François Casas, Christine Feillet-Coudray
Cardiolipin (CL) is a phospholipid at the heart of mitochondrial metabolism, which plays a key role in mitochondrial function and bioenergetics. Among mitochondrial activity regulators, SIRT3 plays a crucial role in controlling the acetylation status of many enzymes participating in the energy metabolism in particular concerning lipid metabolism and fatty acid oxidation. Data suggest that possible connection may exist between SIRT3 and CL status that has not been evaluated in skeletal muscle. In the present study, we have characterized skeletal muscle lipids as well as mitochondrial lipids composition in mice overexpressing long (SIRT3-M1) and short (SIRT3-M3) isoforms of SIRT3...
March 27, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29577261/clock-genes-alterations-and-endocrine-disorders
#3
REVIEW
Anna Angelousi, Eva Kassi, Narjes Nasiri-Ansari, Martin O Weickert, Harpal Randeva, Gregory Kaltsas
BACKGROUND: Various endocrine signals oscillate over the 24-hour period and so does the responsiveness of target tissues. These daily oscillations do not occur solely in response to external stimuli but are also under the control of an intrinsic circadian clock. DESIGN: We searched the PubMed database to identify studies describing the associations of clock genes with endocrine diseases. RESULTS: Various human single nucleotide polymorphisms of BMAL1 and CLOCK genes exhibited significant associations with type 2 diabetes mellitus...
March 25, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29575848/does-learning-style-preferences-in%C3%AF-uence-academic-performance-among-dental-students-in-isfahan-iran
#4
Najmeh Akhlaghi, Hosein Mirkazemi, Mehdi Jafarzade, Narjes Akhlaghi
Purpose: The present study aimed to identify learning preferences of dental students and it's relationships with the academic performance at Dental school, Isfahan, Iran. Methods: This cross-sectional descriptive study included 200 undergraduate dental students from October to November 2016. Data were collected using a questionnaire composed of two parts. The first part included demographic data and the second part was P version of visual, auditory, reading,writing, and kinesthetic (VARK) questionnaire...
March 24, 2018: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/29565756/treatment-challenges-and-outcomes-for-pediatric-intracranial-ependymoma-at-a-single-institution-in-iran
#5
Maryam Tashvighi, Azim Mehrvar, Amir Abbas Hedayati Asl, Narjes Mehrvar, Raheb Ghorbani, Ali Naderi, Mardawig Alebouyeh, Erfan Sattary, Naghmeh Niktoreh Mofrad, Ibrahim Qaddoumi, Mohammad Faranoush
BACKGROUND: The scarcity of information on pediatric ependymoma in Iran motivated this study. Our main objectives were to determine outcomes, identify clinical management challenges at a nongovernment hospital in Iran, and devise guidelines for improving care. PROCEDURE: A retrospective chart review was performed for pediatric patients with ependymoma who were younger than 15 years and treated at MPCTRC between 2007 and 2015. Records included patient demographics, treatment regimens used, duration of follow-up, and outcomes...
March 22, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29562539/a-novel-therapeutic-approach-to-treat-alzheimer-s-disease-by-neurotrophic-support-during-the-period-of-synaptic-compensation
#6
Narjes Baazaoui, Khalid Iqbal
Alzheimer's disease (AD), at present, is considered an incurable disease and a major dilemma with no drug to stop or slow down its progression. Drugs that are currently available in the market are able to only transiently improve the clinical symptoms. The repeated failures in developing an effective drug has led to the suggestion that the medical intervention was probably too late to be effective since the pathology starts many years before the appearance of the clinical symptoms. Probably, at the time of the appearance of clinical symptoms the brain has undergone major neuronal and synaptic loss...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29555959/waist-circumference-is-a-mediator-of-dietary-pattern-in-non-alcoholic-fatty-liver-disease
#7
Alireza Ghaemi, Narjes Hosseini, Saeed Osati, Mohammad Mehdi Naghizadeh, Azizallah Dehghan, Elham Ehrampoush, Behnam Honarvar, Reza Homayounfar
Non-alcoholic fatty liver disease (NAFLD) is an example of pathological fat accumulation in the liver and one of the major health conditions in the world. This study aimed to examine the independent role of dietary patterns in the development of NAFLD. In a cross-sectional study, 1500 individuals referred to a nutrition clinic were randomly selected, their demographic, anthropometric and blood metabolic indices were obtained, and food frequency questionnaires were completed for them. Liver stiffness was calculated using the NAFLD score formula and fibroscan...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29550055/corrigendum-to-phenotype-continuum-between-autism-and-schizophrenia-evidence-from-the-movie-for-the-assessment-of-the-social-cognition-masc-schizophr-res-185-2017-161-166
#8
Gilles Martinez, Charlotte Alexandre, Célia Mam-Lam-Fook, Narjes Bendjemaa, Raphaël Gaillard, Patricia Garel, Isabel Dziobek, Isabelle Amado, Marie-Odile Krebs
No abstract text is available yet for this article.
March 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29518763/medullary-thyroid-cancer-leukemia-mesothelioma-and-meningioma-associated-with-germline-apc-and-rasal1-variants-a-new-syndrome
#9
Anna Angelousi, Nikolaos Settas, Fabio R Faucz, Charalampos Lyssikatos, Martha Quezado, Narjes Nasiri-Ansari, Constantine A Stratakis, Eva Kassi
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor hereditary in 35% of cases. The most common syndromic form is in the context of the multiple endocrine neoplasia type 2 (MEN 2) syndromes in association with other tumors and due to germline RET mutations. We describe a 57-year-old female patient diagnosed with sporadic MTC. The patient had a history of other neoplasias, such as acute myeloid leukemia, for which she had received chemotherapy, and two other solid tumors, peritoneal mesothelioma and meningioma...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29510326/free-radical-synthesis-of-nanosilver-gelatin-poly-acrylic-acid-nanocomposite-hydrogels-employed-for-antibacterial-activity-and-removal-of-cu-ii-metal-ions
#10
Narjes Nemati Dil, Mohammad Sadeghi
The present work involves the synthesis of porous gelatin/AcA (PGE-AcA) hydrogel and novel porous gelatin-silver/AcA (NPGESNC-AcA) nanocomposite hydrogel, and their ability as effective biosorbents for the removal of Cu2+ ions from contaminated water. The formation of the samples was confirmed by UV-Vis, TEM, SEM, EDX, DLS, AFM, XRD, TGA/DTG and FTIR techniques. The adsorption studies results showed that maximum monolayer adsorption capacity of copper ions for PGE-AcA was achieved about 130.50 mg g-1 in pH 6...
February 11, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29510227/long-non-coding-rna-pvt1-as-a-novel-candidate-for-targeted-therapy-in-hematologic-malignancies
#11
Mohammad Houshmand, Narjes Yazdi, Alireza Kazemi, Amir Atashi, Amir Ali Hamidieh, Ali Anjam Najemdini, Mahshid Mohammadi Pour, Mahin Nikougoftar Zarif
Cancerous cells show resistance to various forms of therapy, so applying up to the minute targeted therapy is crucial. For this purpose, long non-coding RNA PVT1 as shown by recent studies is an important oncogene that interacts with vital cellular signaling pathways and different proteins such as c-Myc, NOP2 and LATS2. Due to the enormous role of long non-coding RNAs in development of leukemias, we aimed to show the role of PVT1 knock-down on fate of different hematologic cell lines. owing to this matter, various experiments such as Real-time PCR, cell cycle analysis and apoptosis assay were performed...
March 3, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29478138/genetic-variation-and-association-analysis-of-the-ssr-markers-linked-to-the-major-drought-yield-qtls-of-rice
#12
Narjes Tabkhkar, Babak Rabiei, Habibollah Samizadeh Lahiji, Maryam Hosseini Chaleshtori
Drought is one of the major abiotic stresses, which hampers the production of rice worldwide. Informative molecular markers are valuable tools for improving the drought tolerance in various varieties of rice. The present study was conducted to evaluate the informative simple sequence repeat (SSR) markers in a diverse set of rice genotypes. The genetic diversity analyses of the 83 studied rice genotypes were performed using 34 SSR markers closely linked to the major quantitative trait loci (QTLs) of grain yield under drought stress (qDTYs)...
February 24, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29447937/splenectomy-may-have-more-complications-than-currently-proven
#13
Somayeh Zakeri, Narjes Gorji, Marjan Akhtari, Reihaneh Moeini
The spleen has been one of the least understood major organs for centuries. Its significance is relatively well-known today but it seems that all aspects of its activities are not fully understood. Persian medicine (PM) has special views on the function of spleen; many side effects were reported in PM due to spleen dysfunction. On the other hand nowadays splenectomy as a treatment strategy is recommended for some disorders and increasing risk of infections is considered as the most important long term side effect of that...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29436792/wharton-s-jelly-derived-mesenchymal-stem-cells-isolation-and-characterization
#14
Hossein Ranjbaran, Saeid Abediankenari, Masoud Mohammadi, Narjes Jafari, Alireza Khalilian, Zahra Rahmani, Marzei Momeninezhad Amiri, Pirooz Ebrahimi
Wharton`s jelly-derived mesenchymal stem cells (WJ-MSCs), have a high proliferation valency and they do not produce teratogen or carcinogen after subsequent transplantation. They are known as regenerative medicine. Thus more research is needed on the isolation and characterization of mesenchymal stem cells. In this experimental study, we obtained Wharton's jelly tissues from mothers during normal vaginal delivery, after obtaining their informed consent. Mesenchymal stem cells were isolated from cultured Wharton`s jelly, cultured, and were then examined for their proliferation, immunophenotypes, and differentiation capacities...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29435420/effect-of-curcumin-on-amyloid-like-aggregates-generated-from-methionine-oxidized-apolipoprotein-a-i
#15
Aparna Krishnamoorthy, Narjes Tavoosi, Gary K L Chan, Jianfang Liu, Gang Ren, Giorgio Cavigiolio, Robert O Ryan
Curcumin is a polyphenolic phytonutrient that has antineurodegenerative properties. In this study, we investigated the anti-amyloidogenic properties of curcumin. Following incubation with curcumin, intrinsic tryptophan fluorescence emission of apolipoprotein (apo) A-I was strongly quenched. At the same time, curcumin fluorescence emission was enhanced. The fluorescence emission spectra of curcumin in the presence of amyloid-like aggregates formed by methionine-oxidized (ox) apoA-I varied, depending on whether curcumin was added before, or after, aggregate formation...
February 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29428668/immune-cells-involved-in-the-pathogenesis-of-ankylosing-spondylitis
#16
REVIEW
Alireza Rezaiemanesh, Mohsen Abdolmaleki, Kamal Abdolmohammadi, Hamideh Aghaei, Fatemeh Dadgar Pakdel, Yousef Fatahi, Narjes Soleimanifar, Mahdi Zavvar, Mohammad Hossein Nicknam
Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form of spondyloarthropathies (SpA). The precise etiology of AS has not been fully understood. But Inflammation has a critical role in the pathogenesis of the disease. The immune system by various cells, secreted-mediators and markers manage and regulate the immune responses and inflammation. Every factor which disturbed this regulation and hemostasis can cause chronic inflammation. In this review, we discussed the role of several innate and adaptive immune cells involved in the triggering, initiation, development, and regulation of AS...
February 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29410753/the-effects-of-fractional-co2-laser-nano-hydroxyapatite-and-mi-paste-on-mechanical-properties-of-bovine-enamel-after-bleaching
#17
Horieh Moosavi, Narjes Hakimi
Background: This study investigated the effect of post bleaching treatments to the change of enamel elastic modulus and microhardness after dental bleaching in- vitro. Material and Methods: Fifty bovine incisor slab were randomly assigned into five groups (n=10). The samples were bleached for three times; 20 minutes each time, by 40% hydrogen peroxide. Next it was applied fractional CO2 laser for two minutes, Nano- hydroxy apatite (N-HA) and MI-paste for 7 days and 2 minutes per day...
December 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29407906/theoretical-studies-of-the-second-step-of-the-nitric-oxide-synthase-reaction-electron-tunneling-prevents-uncoupling
#18
Igor Shamovsky, Graham Belfield, Richard Lewis, Frank Narjes, Lena Ripa, Christian Tyrchan, Lisa Öberg, Peter Sjö
Nitric oxide (NO·) is a messenger molecule with diverse physiological roles including host defense, neurotransmission and vascular function. The synthesis of NO· from l-arginine is catalyzed by NO-synthases and occurs in two steps through the intermediary Nω-hydroxy-l-arginine (NHA). In both steps the P450-like reaction cycle is coupled with the redox cycle of the cofactor tetrahydrobiopterin (H4B). The mechanism of the second step is studied by Density Functional Theory calculations to ascertain the canonical sequence of proton and electron transfer (PT and ET) events...
January 10, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29405996/familial-esophageal-squamous-cell-carcinoma-with-damaging-rare-germline-mutations-in-kcnj12-kcnj18-and-gprin2-genes
#19
Narjes Khalilipour, Ancha Baranova, Amir Jebelli, Alireza Heravi-Moussavi, Sergey Bruskin, Mohammad Reza Abbaszadegan
In Iran, esophageal cancer is the fourth common cancers in women and sixth common cancers in men. Here we evaluated the importance of familial risk factors and the role of genetic predisposition in Esophageal Squamous Cell Carcinoma (ESCC) using Whole-Exome Sequencing (WES). Germline damaging mutations were identified in WES data from 9 probands of 9 unrelated ESCC pedigrees. Mutations were confirmed with Sanger sequencing and evaluated amplification-refractory mutation system-Polymerase Chain Reaction (ARMS-PCR) in 50 non-related ethnically matched samples and in complete genomics database...
February 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29403587/ophthalmologic-findings-in-patients-with-neuro-metabolic-disorders
#20
Narjes Jafari, Karl Golnik, Mansoor Shahriari, Parvaneh Karimzadeh, Sayena Jabbehdari
Purpose: We aimed to present the ophthalmic manifestations of neuro-metabolic disorders. Methods: Patients who were diagnosed with neuro-metabolic disorders in the Neurology Department of Mofid Pediatric Hospital in Tehran, Iran, between 2004 and 2014 were included in this study. Disorders were confirmed using clinical findings, neuroimaging, laboratory data, and genomic analyses. All enrolled patients were assessed for ophthalmological abnormalities. Results: A total of 213 patients with 34 different neuro-metabolic disorders were included...
January 2018: Journal of Ophthalmic & Vision Research
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