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https://www.readbyqxmd.com/read/29800695/mir-20a-inhibition-using-locked-nucleic-acid-lna-technology-and-its-effects-on-apoptosis-of-human-macrophages-infected-by-toxoplasma-gondii-rh-strain
#1
Fatemeh Rezaei, Ahmad Daryani, Mohammadreza Sharifi, Shahabeddin Sarvi, Narjes Jafari, Abdol Sattar Pagheh, Nooshin Hashemi, Seyed Hossein Hejazi
Toxoplasma gondii is a ubiquitous and infectious parasite that multiplies in any nucleated cell of warm-blooded animals and humans worldwide. This parasite has intricate mechanisms to reciprocate host-cell apoptosis to exist in the host cell. So far, the details of the parasite interactions with host cells are not well known. MicroRNAs (miRNAs) are one of the small noncoding RNAs that are now considered as a key mechanism of gene regulation. They are important in physiological and pathological processes such as apoptosis...
May 22, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29771705/the-causality-nexus-between-the-tako-tsubo-syndrome-and-an-assault-a-forensic-case-report
#2
Malek Zribi, Syrine Azza Manoubi, Narjes Karray, Salma Charfeddine, Wiem Benamar, Zouhir Hammami, Samir Kammoun, Samir Maatoug
"Tako-tsubo" cardiomyopathy, also known as "broken heart syndrome," is one of the rarest types of stress-induced cardiomyopathy. It frequently mimics acute coronary syndrome, characterized by transient left ventricular dysfunction, electrocardiographic changes, and release of myocardial enzymes. After treatment, the patients are cured in most cases without sequelae. Tako-tsubo syndrome is rarely considered as a reason for consultation in the forensic department.Herein, we report a case of a 68-year-old woman who was assaulted by her police officer neighbor...
May 4, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29761408/parametric-imaging-for-the-assessment-of-cardiac-motion-a-review
#3
REVIEW
Narjes Benameur, Enrico Gianluca Caiani, Younes Arous, Nejmeddine Ben Abdallah, Tarek Kraiem
The assessment of wall motion abnormalities such as hypokinesia or dyskinesia and the identification of their extent as well as their degree of severity allow an accurate evaluation of several ischemic heart diseases and an early diagnosis of heart failure. These dysfunctions are usually revealed by a drop of contraction indicating a regional hypokinesia or a total absence of the wall motion in case of akinesia. The discrimination between these contraction abnormalities plays also a significant role in the therapeutic decision through the differentiation between the infarcted zones, which have lost their contractile function, and the stunned areas that still retain viable myocardial tissues...
May 14, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29749983/from-negligence-to-perception-of-complexities-in-adherence-to-treatment-process-in-people-with-diabetes-a-grounded-theory-study
#4
Seyedeh Narjes Mousavizadeh, Tahereh Ashktorab, Fazlollah Ahmadi, Mitra Zandi
Background: Poor adherence of patients with type 2 diabetes to treatment is one of the most complex and important clinical concerns. It is the main issue of the present decade and acknowledged as a challenge to control and treat diabetes. This study was carried out to explore and understand how adherence to treatment process occurs among Iranian patients with type 2 diabetes. Methods: The present study is qualitative with grounded theory approach. The data were collected from December 2015 to July 2016 in Tehran (Iran) through individual semi-structured in-depth interviews, field notes, and memos from 21 patients with type 2 diabetes; combined with two members of their families and a healthcare professional...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29729704/detection-of-gene-expression-in-sentinel-lymph-node-of-primary-breast-cancer-patients
#5
Shahrzad Soleimani, Shohreh Alizadeh Shargh, Aliasghar Keramatinia, Narjes Mehrvar, Neda Mansouri, Abbas Doosti, Seyed Abdolreza Mortazavi-Tabatabaei, Mehrdad Hashemi, Abolfazl Movafagh
Sentinel lymph node (SLN) micrometstasis detection improves outcome for breast cancer follow up procedure. The aim of the present study was to identify gene profiles that accurately predicted the outcome of breast cancer patients. Fifty tumor sample from breast cancer patients were analyzed for the expression of 3 genes using quantitative-PCR. Also clinical verification for recurrence to distant organs was performed. Three gene signature were confirmed based on tumor's stage, grade, ER status, using conditional logistic regression...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29725278/effectiveness-of-the-teach-back-method-in-improving-self-care-activities-in-postmenopausal-women
#6
Narjes Bahri, Sharareh Saljooghi, Ali Delshad Noghabi, Mahdi Moshki
Introduction: Menopause is a physiological process during which women can improve their quality of life by taking proper self-care measures. Performing self-care requires proper and effective training. The present study was conducted to investigate the effect of self-care training programs based on the teach-back method on the self-care status in postmenopausal women. Material and methods: The present clinical trial was conducted in 2016 in Gonabad, in the east of Iran...
March 2018: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/29717202/double-domain-polyethylenimine-based-nanoparticles-for-integrin-receptor-mediated-delivery-of-plasmid-dna
#7
Hossein Sadeghpour, Bahman Khalvati, Elaheh Entezar-Almahdi, Narjes Savadi, Samira Hossaini Alhashemi, Mohammad Raoufi, Ali Dehshahri
The objective of the present study is to conjugate L-thyroxine PEI derivative onto another PEI to compensate the amine content of the whole structure which has been utilized for the ligand conjugation. Since αv β3 integrin receptors are over-expressed on cancer cells and there is binding site for L-thyroxine on these receptors, PEI conjugation by L-thyroxine along with restoring the PEI amine content might be an efficient strategy for targeted delivery using polymeric nanoparticles. The results demonstrated the ability of the PEI conjugate in the formation of nanoparticles with the size of around 210 nm with higher buffering capacity...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29710513/alterations-in-oxidative-stress-markers-and-its-correlation-with-clinical-findings-in-schizophrenic-patients-consuming-perphenazine-clozapine-and-risperidone
#8
Narjes Hendouei, Samaneh Farnia, Farhad Mohseni, Azadeh Salehi, Maedeh Bagheri, Faezeh Shadfar, Fatemeh Barzegar, Seyed Davood Hoseini, Jamshid Yazdani Charati, Fatemeh Shaki
BACKGROUND AND OBJECTIVE: Today, the role of oxidative stress in development of schizophrenia has gained attention. Also, some atypical antipsychotic agents showed antioxidant properties. Therefore, in this study, we evaluated the level of oxidative stress parameters between patients treated with perphenazine, clozapine and risperidone and their relationship with schizophrenia symptoms' severity. MATERIALS AND METHODS: This was a descriptive study on 100 patients with chronic schizophrenia...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29696051/are-there-neurological-symptoms-in-type-1-of-gaucher-disease
#9
Mohammadreza Alaei, Narjes Jafari, Farzaneh Rohani, Farzad Ahmadabadi, Rezvan Azadi
Objective: Gaucher disease (GD) is a rare inborn error of metabolism, classified as a lipid storage disorders. This disease is caused by a deficiency in glucocerebrosidase enzyme. It has been classified according to the presence or absence of neurological symptoms into the following types: type 1 non-neuropathic, type 2 acute infantile neuropathic and type 3 or chronic neuropathic. We evaluated neurological symptoms in patients with GD1 and GD3 and compared both of these groups. Materials & Methods: Eleven patients were identified according to their clinical presentation and the presence of disease confirmed by genetic testing, from 2006-2016, at the Mofid Children Hospital Clinic, Tehran, Iran...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29656601/culture-independent-analysis-of-hydrocarbonoclastic-bacterial-communities-in-environmental-samples-during-oil-bioremediation
#10
Narjes Dashti, Nedaa Ali, Samar Salamah, Majida Khanafer, Ghada Al-Shamy, Husain Al-Awadhi, Samir S Radwan
To analyze microbial communities in environmental samples, this study combined Denaturing Gradient Gel Electrophoresis of amplified 16S rRNA-genes in total genomic DNA extracts from those samples with gene sequencing. The environmental samples studied were oily seawater and soil samples, that had been bioaugmented with natural materials rich in hydrocarbonoclastic bacteria. This molecular approach revealed much more diverse bacterial taxa than the culture-dependent method we had used in an earlier study for the analysis of the same samples...
April 15, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29589261/skeletal-muscle-overexpression-of-short-isoform-sirt3-altered-mitochondrial-cardiolipin-content-and-fatty-acid-composition
#11
Béatrice Chabi, Gilles Fouret, Jérome Lecomte, Fabienne Cortade, Laurence Pessemesse, Narjès Baati, Charles Coudray, Ligen Lin, Qiang Tong, Chantal Wrutniak-Cabello, François Casas, Christine Feillet-Coudray
Cardiolipin (CL) is a phospholipid at the heart of mitochondrial metabolism, which plays a key role in mitochondrial function and bioenergetics. Among mitochondrial activity regulators, SIRT3 plays a crucial role in controlling the acetylation status of many enzymes participating in the energy metabolism in particular concerning lipid metabolism and fatty acid oxidation. Data suggest that possible connection may exist between SIRT3 and CL status that has not been evaluated in skeletal muscle. In the present study, we have characterized skeletal muscle lipids as well as mitochondrial lipids composition in mice overexpressing long (SIRT3-M1) and short (SIRT3-M3) isoforms of SIRT3...
April 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29577261/clock-genes-alterations-and-endocrine-disorders
#12
REVIEW
Anna Angelousi, Eva Kassi, Narjes Nasiri-Ansari, Martin O Weickert, Harpal Randeva, Gregory Kaltsas
BACKGROUND: Various endocrine signals oscillate over the 24-hour period and so does the responsiveness of target tissues. These daily oscillations do not occur solely in response to external stimuli but are also under the control of an intrinsic circadian clock. DESIGN: We searched the PubMed database to identify studies describing the associations of clock genes with endocrine diseases. RESULTS: Various human single nucleotide polymorphisms of brain and muscle ARNT-like 1 (BMAL1) and Circadian Locomotor Output Cycles Kaput (CLOCK) genes exhibited significant associations with type 2 diabetes mellitus...
March 25, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29575848/does-learning-style-preferences-influence-academic-performance-among-dental-students-in-isfahan-iran
#13
Najmeh Akhlaghi, Hosein Mirkazemi, Mehdi Jafarzade, Narjes Akhlaghi
PURPOSE: The present study aimed to identify the learning preferences of dental students and to characterize their relationship with academic performance at a dental school in Isfahan, Iran. METHODS: This cross-sectional descriptive study included 200 undergraduate dental students from October to November 2016. Data were collected using a 2-part questionnaire. The first part included demographic data, and the second part was a Persian-language version of the visual, aural, read/write, and kinesthetic questionnaire...
2018: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/29565756/treatment-challenges-and-outcomes-for-pediatric-intracranial-ependymoma-at-a-single-institution-in-iran
#14
Maryam Tashvighi, Azim Mehrvar, Amir Abbas Hedayati Asl, Narjes Mehrvar, Raheb Ghorbani, Ali Naderi, Mardawig Alebouyeh, Erfan Sattary, Naghmeh Niktoreh Mofrad, Ibrahim Qaddoumi, Mohammad Faranoush
BACKGROUND: The scarcity of information on pediatric ependymoma in Iran motivated this study. Our main objectives were to determine outcomes, identify clinical management challenges at a nongovernment hospital in Iran, and devise guidelines for improving care. PROCEDURE: A retrospective chart review was performed for pediatric patients with ependymoma who were younger than 15 years and treated at MPCTRC between 2007 and 2015. Records included patient demographics, treatment regimens used, duration of follow-up, and outcomes...
February 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29562539/a-novel-therapeutic-approach-to-treat-alzheimer-s-disease-by-neurotrophic-support-during-the-period-of-synaptic-compensation
#15
Narjes Baazaoui, Khalid Iqbal
Alzheimer's disease (AD), at present, is considered an incurable disease and a major dilemma with no drug to stop or slow down its progression. Drugs that are currently available in the market are able to only transiently improve the clinical symptoms. The repeated failures in developing an effective drug has led to the suggestion that the medical intervention was probably too late to be effective since the pathology starts many years before the appearance of the clinical symptoms. Probably, at the time of the appearance of clinical symptoms the brain has undergone major neuronal and synaptic loss...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29555959/waist-circumference-is-a-mediator-of-dietary-pattern-in-non-alcoholic-fatty-liver-disease
#16
Alireza Ghaemi, Narjes Hosseini, Saeed Osati, Mohammad Mehdi Naghizadeh, Azizallah Dehghan, Elham Ehrampoush, Behnam Honarvar, Reza Homayounfar
Non-alcoholic fatty liver disease (NAFLD) is an example of pathological fat accumulation in the liver and one of the major health conditions in the world. This study aimed to examine the independent role of dietary patterns in the development of NAFLD. In a cross-sectional study, 1500 individuals referred to a nutrition clinic were randomly selected, their demographic, anthropometric and blood metabolic indices were obtained, and food frequency questionnaires were completed for them. Liver stiffness was calculated using the NAFLD score formula and fibroscan...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29550055/corrigendum-to-phenotype-continuum-between-autism-and-schizophrenia-evidence-from-the-movie-for-the-assessment-of-the-social-cognition-masc-schizophr-res-185-2017-161-166
#17
Gilles Martinez, Charlotte Alexandre, Célia Mam-Lam-Fook, Narjes Bendjemaa, Raphaël Gaillard, Patricia Garel, Isabel Dziobek, Isabelle Amado, Marie-Odile Krebs
No abstract text is available yet for this article.
March 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29518763/medullary-thyroid-cancer-leukemia-mesothelioma-and-meningioma-associated-with-germline-apc-and-rasal1-variants-a-new-syndrome
#18
Anna Angelousi, Nikolaos Settas, Fabio R Faucz, Charalampos Lyssikatos, Martha Quezado, Narjes Nasiri-Ansari, Constantine A Stratakis, Eva Kassi
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor hereditary in 35% of cases. The most common syndromic form is in the context of the multiple endocrine neoplasia type 2 (MEN 2) syndromes in association with other tumors and due to germline RET mutations. We describe a 57-year-old female patient diagnosed with sporadic MTC. The patient had a history of other neoplasias, such as acute myeloid leukemia, for which she had received chemotherapy, and two other solid tumors, peritoneal mesothelioma and meningioma...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29510326/free-radical-synthesis-of-nanosilver-gelatin-poly-acrylic-acid-nanocomposite-hydrogels-employed-for-antibacterial-activity-and-removal-of-cu-ii-metal-ions
#19
Narjes Nemati Dil, Mohammad Sadeghi
The present work involves the synthesis of porous gelatin/AcA (PGE-AcA) hydrogel and novel porous gelatin-silver/AcA (NPGESNC-AcA) nanocomposite hydrogel, and their ability as effective biosorbents for the removal of Cu2+ ions from contaminated water. The formation of the samples was confirmed by UV-Vis, TEM, SEM, EDX, DLS, AFM, XRD, TGA/DTG and FTIR techniques. The adsorption studies results showed that maximum monolayer adsorption capacity of copper ions for PGE-AcA was achieved about 130.50 mg g-1 in pH 6...
June 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29510227/long-non-coding-rna-pvt1-as-a-novel-candidate-for-targeted-therapy-in-hematologic-malignancies
#20
Mohammad Houshmand, Narjes Yazdi, Alireza Kazemi, Amir Atashi, Amir Ali Hamidieh, Ali Anjam Najemdini, Mahshid Mohammadi Pour, Mahin Nikougoftar Zarif
Cancerous cells show resistance to various forms of therapy, so applying up to the minute targeted therapy is crucial. For this purpose, long non-coding RNA PVT1 as shown by recent studies is an important oncogene that interacts with vital cellular signaling pathways and different proteins such as c-Myc, NOP2 and LATS2. Due to the enormous role of long non-coding RNAs in development of leukemias, we aimed to show the role of PVT1 knock-down on fate of different hematologic cell lines. owing to this matter, various experiments such as Real-time PCR, cell cycle analysis and apoptosis assay were performed...
May 2018: International Journal of Biochemistry & Cell Biology
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