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https://www.readbyqxmd.com/read/28759882/oculomotricity-and-neurological-soft-signs-can-we-refine-the-endophenotype-a-study-in-subjects-belonging-to-the-spectrum-of-schizophrenia
#1
Simona Caldani, Isabelle Amado, Narjes Bendjemaa, François Vialatte, Célia Mam-Lam-Fook, Raphael Gaillard, Marie-Odile Krebs, Maria Pia Bucci
Alterations in eye tracking and motor impairments as well as Neurological Soft Signs (NSS) are frequently reported in patients with schizophrenia as well as in their relatives, and are proposed as endophenotype of the disease. This study investigated smooth pursuit eye movement and fixation task with distractors with a gap condition, two markers of inhibitory control mechanism, in 49 patients with schizophrenia, 24 ultra-high risk subjects, 41 full biological clinical siblings of patients and 48 controls. NSS were assessed as a marker of abnormal neurodevelopment...
June 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28754766/divergent-evolution-and-niche-differentiation-within-the-common-peatmoss-sphagnum-magellanicum
#2
Narjes Yousefi, Kristian Hassel, Kjell Ivar Flatberg, Petri Kemppainen, Emiliano Trucchi, A Jonathan Shaw, Magni Olsen Kyrkjeeide, Péter Szövényi, Hans K Stenøien
PREMISE OF THE STUDY: Populations with phenotypic polymorphism in discrete characters may be good models for investigating genome evolution and speciation. Sphagnum magellanicum Brid. is found throughout the northern hemisphere, and despite considerable variation in morphological characters, it is considered one of the least taxonomically controversial peatmoss species. We have observed two main morphs of the species associated with different microhabitats. Here we investigated the genomic and environmental basis of this intraspecific morphological variation...
July 28, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28748171/effect-of-linalool-on-the-acquisition-and-reinstatement-of-morphine-induced-conditioned-place-preference-in-mice
#3
Narjes Pourtaqi, Mohsen Imenshahidi, Bibi Marjan Razavi, Hossein Hosseinzadeh
OBJECTIVE: The effect of linalool, a terpene alcohol found in many plants, which inhibits NMDA receptors, on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) was evaluated in mice. MATERIAL AND METHODS: The effects of different doses of linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg, an NMDA receptor antagonist) and saline, in CPP induced by 40 mg/kg of morphine were investigated in mice. In another experiment, a single injection of morphine (10 mg/kg) reinstated the place reference following extinction of a place preference induced by morphine (40 mg/kg)...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28745903/trend-of-socio-demographic-index-and-mortality-estimates-in-iran-and-its-neighbors-1990-2015-findings-of-the-global-burden-of-diseases-2015-study
#4
Maziar Moradi-Lakeh, Sadaf G Sepanlou, Seyed M Karimi, Narjes Khalili, Shirin Djalalinia, Chante Karimkhani, Kristopher Krohn, Ashkan Afshin, Farshad Farzadfar, Aliasghar Ahmad Kiadaliri, Mohsen Asadi-Lari, Hamid Asayesh, Ali Reza Esteghamati, Maryam S Farvid, Seyed-Mohammad Fereshtehnejad, Pouria Heydarpour, Ardeshir Khosravi, Jagdish Khubchandani, Amir Kasaeian, Saleem M Rana, Mahdi Mahdavi, Habib Masoudifarid, Alireza Mohammadi, Farshad Pourmalek, Mostafa Qorbani, Amir Radfar, Kazem Rahimi, Vafa Rahimi-Movaghar, Gholamreza Roshandel, Sare Safi, Payman Salamati, Arash Tehrani-Banihashemi, Shahrzad Bazargan-Hejazi, Theo Vos, Reza Malekzadeh, Ali H Mokdad, Christopher J L Murray, Mohsen Naghavi
BACKGROUND: The Global burden of disease and injuries study (GBD 2015) reports expected measures for years of life lost (YLL) based on socio-demographic index (SDI) of countries, as well as the observed measures. In this extended GBD 2015 report, we reviewed total and cause-specific deaths and YLL for Iran and all its neighboring countries between 1990 and 2015. METHODS: We extracted data from the GBD 2015 database. Observed YLL measures were calculated by multiplying the number of deaths by standard life expectancy at each age...
July 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28717128/mother-s-pre-pregnancy-bmi-and-placental-candidate-mirnas-findings-from-the-environage-birth-cohort
#5
Maria Tsamou, Dries S Martens, Ellen Winckelmans, Narjes Madhloum, Bianca Cox, Wilfried Gyselaers, Tim S Nawrot, Karen Vrijens
There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child's predisposition to develop disease later in life. The aim of this study is to investigate the association between maternal pre-pregnancy body mass index (BMI) and miRNA alterations in placental tissue at birth. In 211 mother-newborn pairs from the ENVIRONAGE birth cohort, we assessed placental expression of seven miRNAs important in crucial cellular processes implicated in adipogenesis and/or obesity...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698861/spiritual-therapy-in-coping-with-cancer-as-a-complementary-medical-preventive-practice
#6
REVIEW
Abolfazl Movafagh, Mohammad Hassan Heidari, Morteza Abdoljabbari, Neda Mansouri, Afsoon Taghavi, Aliasghar Karamatinia, Narjes Mehrvar, Mehrdad Hashemi, Mona Ghazi
There are many of methods of treating cancer. However, the concept of curing the cancer is beyond our current knowledge. Some patients who have the cancer may seek an alternative manner of curing their disease. Alternative medicines, such as spiritual and complementary therapy, are able to cure the cancer and, at the least, are safe. Research on the importance of spirituality in cancer care has mainly been performed in geographically heterogeneous populations. The results are limited to these specific religious-cultural contexts and enlightened by contributions from ethnicity and religion...
June 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28698860/genomic-profiling-of-chronic-myelogenous-leukemia-basic-and-clinical-approach
#7
REVIEW
Aliasghar Keramatinia, Alireza Ahadi, Mohammad Esmaeil Akbari, Maryam Mohseny, Alireza Mosavi Jarahi, Narjes Mehrvar, Neda Mansouri, S A Mortazavi Tabatabaei, Abolfazl Movafagh
Chronic myeloid leukemia (CML) is a hematological stem cell cancer driven by BCR-ABL1 fusion protein. We review the previous and recent evidence on the significance of CML in diagnostic and clinic management. The technical monitoring of BCR-ABL1 with quantitative real time-PCR has been used in assessing patient outcome. The cytogenetic mark of CML is Philadelphia chromosome, that is formed by reciprocal chromosomal translocations between human chromosome 9 and 22, t(9:22) (q(34):q(11)). It makes a BCR-ABL1 fusion protein with an anomaly tyrosine kinase activity that promotes the characteristic proliferation of progenitor cells in CML and acute lymphoblastic lymphoma...
June 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28698724/hla-b-1502-in-iranian-children-with-anticonvulsant-drugs-induced-skin-reactions
#8
Seyed Hasan Tonekaboni, Narjes Jafari, Mahboubeh Mansouri, Sayena Jabbehdari, Rahil Eftekhari, Zahra Chavoshzadeh, Fatemeh Abdollah Gorji, Mehrnaz Mesdaghi
OBJECTIVE: Anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. An association between HLA-B*1502 allele and severe skin reactions have been reported. MATERIALS & METHODS: Fifteen patients with severe skin reactions following treatment with anticonvulsant drugs (Carbamazepine, lamotrigine, phenobarbital, primidone) and 15 controls (age-matched epileptic patients taking similar anticonvulsants without drug eruption) were included...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28676454/myostatin-deficiency-is-associated-with-lipidomic-abnormalities-in-skeletal-muscles
#9
Narjes Baati, Christine Feillet-Coudray, Gilles Fouret, Barbara Vernus, Bénédicte Goustard, Charles Coudray, Jérome Lecomte, Véronique Blanquet, Laetitia Magnol, Anne Bonnieu, Christelle Koechlin-Ramonatxo
Myostatin (Mstn) deficiency leads to skeletal muscle overgrowth and Mstn inhibition is considered as a promising treatment for muscle-wasting disorders. Mstn gene deletion in mice also causes metabolic changes with decreased mitochondria content, disturbance in mitochondrial respiratory function and increased muscle fatigability. However the impact of MSTN deficiency on these metabolic changes is not fully elucidated. Here, we hypothesized that lack of MSTN will alter skeletal muscle membrane lipid composition in relation with pronounced alterations in muscle function and metabolism...
July 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28667548/synthetic-co-attractants-of-the-aggregation-pheromone-of-the-date-palm-root-borer-oryctes-agamemnon
#10
Narjes Hasni, Centina Pinier, Cheraief Imed, Monêem Ouhichi, Philippe Couzi, Brahim Chermiti, Brigitte Frérot, Imen Saïd, Didier Rochat
Laboratory and field investigations to identify and evaluate plant co-attractants of the aggregation pheromone of the date palm pest Oryctes agamemnon are reported. Volatiles emitted by freshly cut palm core and palm core with feeding males, were collected, analyzed by gas chromatography coupled to mass spectrometry and evaluated in olfactometers alone or combined with synthetic pheromone. A collection of palm odor without male effluvia was attractive alone and enhanced attraction to synthetic pheromone in an olfactometer similar to that to a collection of palm odor emitted with feeding males and containing natural pheromone...
June 30, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28655344/prevention-of-dendritic-and-synaptic-deficits-and-cognitive-impairment-with-a-neurotrophic-compound
#11
Narjes Baazaoui, Khalid Iqbal
BACKGROUND: The use of neurotrophic factors to treat Alzheimer's disease (AD) is hindered by their blood-brain barrier impermeability, short half-life, and severe side effects. Peptide 021 (P021) is a neurotrophic/neurogenic tetra-peptide that was derived from the most active region of the ciliary neurotrophic factor (CNTF) by epitope mapping. Admantylated glycine was added to its C-terminal to increase its blood-brain barrier permeability and decrease its degradation by exopeptidases to make it druggable...
June 27, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28633823/sono-synthesis-of-solar-light-responsive-s-n-c-tri-doped-tio2-photo-catalyst-under-optimized-conditions-for-degradation-and-mineralization-of-diclofenac
#12
Sara Ramandi, Mohammad H Entezari, Narjes Ghows
C-N-S-tri doped TiO2 anatase phase was synthesized using a facile, effective and novel sonochemical method at low frequency (20kHz) and at room temperature. Titanium butoxide as the titanium precursor and thiourea as the dopant source were used in the synthesis of the photo-catalyst. The effects of important parameters such as thiourea/Ti molar ratio, ultrasound intensity, sonication time and temperature were studied on the synthesis of tri-doped TiO2. The XPS results confirmed the presence of N, S, and C in the photo-catalyst...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28627375/modulation-of-sphingosine-1-phosphate-receptor-ameliorates-harmaline-induced-essential-tremor-in-rat
#13
Narjes Dahmardeh, Majid Asadi-Shekaari, Shokouh Arjmand, Tajpari Kalantaripour, Mohsen Basiri, Mohammad Shabani
Essential tremor (ET) is one of the most common movement disorders with unknown etiology. Despite lack of effective clinical treatments, some potential therapeutic factors and modulation of some neurotransmitters have been utilized to ameliorate motor symptoms in the animal models of tremor. In the current study, male Wistar rats (n=10 in each group) weighing 40-60g were divided into vehicle control groups (saline or DMSO), saline/DMSO+harmaline (30mg/kg, i.p.)+fingolimod (FTY720) (1mg/kg, i.p, 1h before harmaline injection) groups...
July 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28610971/metabolic-engineering-of-escherichia-coli-cell-factory-for-highly-active-xanthine-dehydrogenase-production
#14
Cheng-Hua Wang, Chong Zhang, Xin-Hui Xing
The aim of this work was to demonstrate the first proof-of-concept for the use of ab initio-aided assembly strategy intensifying in vivo biosynthesis process to construct Escherichia coli cell factory overproducing highly active xanthine dehydrogenase (XDH). Three global regulator (IscS, TusA and NarJ) and four chaperone proteins (DsbA, DsbB, NifS and XdhC) were overexpressed to aid the formation and ordered assembly of three redox center cofactors of Rhodobacter capsulatus XDH in E. coli. The NifS, IscS and DsbB enhanced the specific activity of RcXDH by 30%, 94% and 49%, respectively...
May 31, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28595182/the-effect-of-dietary-supplements-containing-green-tea-capsaicin-and-ginger-extracts-on-weight-loss-and-metabolic-profiles-in-overweight-women-a-randomized-double-blind-placebo-controlled-clinical-trial
#15
Mohsen Taghizadeh, Narjes Farzin, Sara Taheri, Mahnaz Mahlouji, Hossein Akbari, Fatemeh Karamali, Zatollah Asemi
BACKGROUND: This study was conducted to determine the effects of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles among overweight women. METHODS: This randomized double-blind placebo-controlled clinical trial was implemented among 50 overweight women. Participants were randomly divided into 2 groups. Group A received dietary supplements containing 125 mg green tea, 25 mg capsaicin and 50 mg ginger extracts (n = 25) group B received placebos (n = 25) twice with lunch and twice with dinner daily for 8 weeks...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28585059/erratum-to-association-between-serum-and-synovial-fluid-dickkopf-1-levels-with-radiographic-severity-in-primary-knee-osteoarthritis-patients
#16
Thomas Theologis, Nikolaos Efstathopoulos, Vasileios Nikolaou, Ioannis Charikopoulos, Ioannis Papapavlos, Panayiotis Kokkoris, Athanasios Papatheodorou, Narjes Nasiri-Ansari, Eva Kassi
No abstract text is available yet for this article.
August 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28555309/comprehensive-analysis-of-iranian-reports-of-pediatric-central-nervous-system-tumors
#17
Narjes Mehrvar, Azim Mehrvar, Mohammad Esmaeil Akbari, Ibrahim Qaddoumi
PURPOSE: Iran lacks a national registry reporting the data of central nervous system (CNS) tumors in children. Consequently, treatment success and failure rates are unknown, and a centralized system for disease-management recommendations does not exist. METHODS: To critically evaluate the current state of pediatric CNS tumor studies and reporting in Iran, we performed an extensive retrospective analysis of all known reports identified with multiple search engines...
May 29, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28553582/segmentation-of-white-blood-cells-from-microscopic-images-using-a-novel-combination-of-k-means-clustering-and-modified-watershed-algorithm
#18
Narjes Ghane, Alireza Vard, Ardeshir Talebi, Pardis Nematollahy
Recognition of white blood cells (WBCs) is the first step to diagnose some particular diseases such as acquired immune deficiency syndrome, leukemia, and other blood-related diseases that are usually done by pathologists using an optical microscope. This process is time-consuming, extremely tedious, and expensive and needs experienced experts in this field. Thus, a computer-aided diagnosis system that assists pathologists in the diagnostic process can be so effective. Segmentation of WBCs is usually a first step in developing a computer-aided diagnosis system...
April 2017: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/28545656/cord-plasma-insulin-and-in-utero-exposure-to-ambient-air-pollution
#19
Narjes Madhloum, Bram G Janssen, Dries S Martens, Nelly D Saenen, Esmée Bijnens, Wilfried Gyselaers, Joris Penders, Charlotte Vanpoucke, Wouter Lefebvre, Michelle Plusquin, Tim S Nawrot
INTRODUCTION: Cardio-metabolic risk factors including insulin levels are at young age barely perceived as harmful, but over time these risk factors may track and lead to higher risk of metabolic syndrome. Studies showed that exposure to air pollution is associated with an increased risk of insulin resistance in childhood. We determined whether the origin of type 2 diabetes can be found in the early childhood by examining the levels of insulin in the neonatal cord blood and whether this can be considered as a disease marker for later life...
August 2017: Environment International
https://www.readbyqxmd.com/read/28523255/the-effect-of-husbands-education-regarding-menopausal-health-on-marital-satisfaction-of-their-wives
#20
Nooshin Yoshany, Mohammad Ali Morowatisharifabad, Hamideh Mihanpour, Narjes Bahri, Khair Mohammad Jadgal
OBJECTIVES: Marital satisfaction has an important effect on people's mental health. Due to the increasing average age and life expectancy of Iranian women, obtaining knowledge about sexual aspects of post-menopause women for partners can improve their health and quality of life. This study aimed to determine the effect of education for the husbands regarding menopause on marital satisfaction of their wives. METHODS: This randomized controlled trial was conducted on 100 women aged 45 to 55 years old and their husbands in Yazd in 2014...
April 2017: Journal of Menopausal Medicine
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