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https://www.readbyqxmd.com/read/29214340/management-and-outcomes-of-treating-pediatric-medulloblastoma-an-eight-years-experience-in-an-iranian-pediatric-center
#1
Azim Mehrvar, Maryam Tashvighi, Amir Abbas Hedayati Asl, Naghmeh Niktoreh-Mofrad, Narjes Mehrvar, Negar Afsar, Ali Naderi, Mardawig Allebouyeh, Ibrahim Qaddoumi, Mohammad Faranoush
PURPOSE: The clinical management of pediatric medulloblastoma requires a multidisciplinary approach, which can be challenging, especially in low- and middle-income countries. The aim of this study was to identify current challenges and describe the treatment and outcomes of Iranian pediatric patients with medulloblastoma who were referred to our center in Tehran, Iran. METHODS: Our retrospective review included 126 patient records from April 2007 to May 2015. The records were analyzed for epidemiologic features, treatment modalities, overall survival, and progression-free survival...
December 6, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29208493/almond-hazelnut-and-walnut-three-nuts-for-neuroprotection-in-alzheimer-s-disease-a-neuropharmacological-review-of-their-bioactive-constituents
#2
REVIEW
Narjes Gorji, Reihaneh Moeini, Zahra Memariani
An increase in the prevalence of Alzheimer's disease (AD) as a multifactorial neurodegenerative disorder is an almost obvious issue in the world. Researches on natural products for finding effective drugs to prevent the disease are in progress. There is special attention to the three types of nuts including almond, hazelnut and walnut in manuscripts of traditional Persian medicine (PM) as preventive agents against brain's atrophy and memory loss. The purpose of this study is a pharmacological review of their bioactive constituents and introducing the value of these nuts as effective supplements and natural medicinal foods in AD patients...
December 2, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29190604/metabolic-response-to-mulberry-extract-supplementation-in-patients-with-diabetic-nephropathy-a-randomized-controlled-trial
#3
Mohsen Taghizadeh, Alireza Soleimani, Fereshteh Bahmani, Alireza Moravveji, Amir Asadi, Elahe Amirani, Narjes Farzin, Nasrin Sharifi, Afshin Naseri, Majid Dastorani, Zatollah Asemi
INTRODUCTION: This study aimed to evaluate the effects of mulberry extract administration on markers of insulin metabolism, lipid concentrations, and biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy (DN). MATERIALS AND METHODS: Sixty patients were randomly allocated into 2 groups to receive either 300 mg/d of mulberry extract (n = 30) or placebo (n = 30), twice per day for 12 weeks. Fasting blood samples were taken at the onset of the study and 12 weeks after supplementation to examine markers of insulin metabolism, lipid concentrations, and biomarkers of inflammation and oxidative stress...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29156426/theory-of-mind-and-schizophrenia-in-young-and-middle-aged-patients-influence-of-executive-functions
#4
Marta Croca, Aurèlie Lagodka, Remi Gadel, Marie Chantal Bourdel, Narjes Bendjemaa, Raphael Gaillard, Jean Pierre Olié, M Champagne-Lavau, Marie Odile Krebs, Isabelle Amado
Theory of Mind (ToM) is compromised in schizophrenia, and responsible for social disability. We aim to study the correlation between ToM deficits and Executive Functions (EF), using the Faux Pas Test (FPT) for ToM evaluation, Behavioral Assessment of the Dysexecutive Syndrome (BADS) and Wisconsin Card Sorting Test (WCST) for EF assessment. Two groups of patients with schizophrenia were included: 22 young (18-35 years-old) and 18 middle-aged (>50 years-old) Patients, compared to age-matched Controls. We found worst FPT performances in both groups of patients, but with a more generalized pattern of dysfunction in the middle-aged patient group...
November 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29154410/predicting-success-of-methotrexate-treatment-by-pretreatment-hcg-level-and-24-hour-hcg-increment
#5
Gabriel Levin, Narjes A Saleh, Rani Haj-Yahya, Liat S Matan, Avi Benshushan
OBJECTIVE: To evaluate β-human chorionic gonadotropin (β-HCG) level and its 24-hour increment as predictors of successful methotrexate treatment for ectopic pregnancy. METHODS: Data were retrospectively reviewed from women with ectopic pregnancy who were treated by single-dose methotrexate (50 mg/m(2) ) at a university hospital in Jerusalem, Israel, between January 1, 2000, and June 30, 2015. Serum β-HCG before treatment and its percentage increment in the 24 hours before treatment were compared between treatment success and failure groups...
November 20, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29124622/medicinal-plants-with-antithrombotic-property-in-persian-medicine-a-mechanistic-review
#6
REVIEW
Zahra Memariani, Reihaneh Moeini, Shokooh Sadat Hamedi, Narjes Gorji, Seyyed Ali Mozaffarpur
Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessels diseases. Due to the high prevalence of thromboembolic disorders investigations are being carried out on new antithrombotic agents with limited adverse side effects in which herbal medicines are considered as alternative remedies. Persian medicine (PM) as a traditional medicine has a good potential for pharmacotherapy based on its own principles and development of drugs via investigating PM literature. In PM manuscripts there are some concepts that express the management of blood clots and antithrombotic properties...
November 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29052151/hair-mercury-and-risk-assessment-for-consumption-of-contaminated-seafood-in-residents-from-the-coast-of-the-persian-gulf-iran
#7
Narjes Okati, Abbas Esmaili-Sari
The health risks of mercury exposure due to the high consumption of aquatic were assessed for fishermen and non-fishermen families living on the Bandar Abbas, Bushehr, and Mahshahr cities located in the coast of Persian Gulf (Iran). The mean hair mercury concentration of people in Bandar Abbas, Bushehr, and Mahshahr cities was obtained 1.56 ± 0.17, 1.97 ± 0.22, and 5.12 ± 0.3 μg g(-1), respectively. Hair mercury concentration in 8.8% of people exceeded the no observed adverse effects level (NOAEL) of 10 μg g(-1) declared by the World Health Organization (WHO)...
October 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29026505/indicator-for-success-of-obesity-reduction-programs-in-adolescents-body-composition-or-body-mass-index-evaluating-a-school-based-health-promotion-project-after-12-weeks-of-intervention
#8
Naser Kalantari, Nastaran Keshavarz Mohammadi, Shahram Rafieifar, Hassan Eini-Zinab, Atefeh Aminifard, Hanieh Malmir, Narjes Ashoori, Sheyda Abdi, Maryam Gholamalizadeh, Saeid Doaei
BACKGROUND: Obesity in adolescence is the strongest risk factor for obesity in adulthood. This study aimed to evaluate the effects of a comprehensive lifestyle intervention on different anthropometric indices in 12-16-year-old boy adolescents after 12 Weeks of Intervention. METHODS: A total of 96 male adolescents from two schools participated in this study. The schools were randomly assigned to intervention (53 students) and control school (43 students). Height and weight of students were measured and their body mass index (BMI) was calculated...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28956097/determination-of-mercury-daily-intake-and-hair-to-blood-mercury-concentration-ratio-in-people-resident-of-the-coast-of-the-persian-gulf-iran
#9
Narjes Okati, Abbas Esmaili-Sari
The objectives of this study were to understand the mercury daily intake and hair-to-blood mercury ratio in fishermen and non-fishermen families in the coast of the Persian Gulf in Iran. The mean mercury concentration in the hair of fishermen and non-fishermen families was 5.76 and 2.27 μg/g, respectively. The mean mercury concentrations of RBCs were obtained for fishermen families and non-fishermen families: 35.96 and 17.18 μg/L, respectively. Hair mercury concentrations in 17% of people were higher than 10 μg/g, the No Observed Adverse Effects Level set by the World Health Organization...
September 27, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28951694/efficacy-of-topical-coriandrum-sativum-extract-on-treatment-of-infants-with-diaper-dermatitis-a-single-blinded-non-randomised-controlled-trial
#10
Ladan Dastgheib, Narjes Pishva, Nasrin Saki, Soghra Khabnadideh, Bahareh Kardeh, Fatemeh Torabi, Shahram Arabnia, Alireza Heiran
Diaper dermatitis is a common disorder. Coriandrum sativum is a herbal remedy with anti-inflammatory, analgesic, anti-microbial and anti-oxidant activities effects. In this non randomised clinical trial which was performed on 58 infants with diaper dermatitis referred to Faghihi Hospital, Shiraz University of Medical Sciences, the efficacy and safety of topical Coriandrum extract cream is compared with hydrocortisone ointment. Coriandrum sativum extract cream was administered for 37 (intervention group) and hydrocortisone 1% ointment for 21 (control group) patients...
August 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28950006/adverse-drug-reactions-reported-to-the-drug-and-poison-information-center-of-tehran-iran
#11
Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Mohammadreza Javadi, Kheirollah Gholami
BACKGROUND: Burden of adverse drug reactions (ADRs), in home-environment and domestic settings, is unknown. OBJECTIVE: To discuss the epidemiology of reported ADRs to 13-Aban drug and poison information center (DPIC) and to discuss the burden of hospitalization caused by these ADRs from commonly implicated therapeutic groups. METHODS: A retrospective analysis of the yellow card schemes of suspected ADRs reported to the 13-Aban DPIC was conducted from 21 March 2013 to 21 November 2016 inclusive...
2017: PloS One
https://www.readbyqxmd.com/read/28925879/human-fibronectin-extra-domain-b-edb-speci%C3%AF-c-aptide-aptedb-radiolabelling-with-technetium-99m-as-a-potent-targeted-tumour-imaging-agent
#12
Mohsen Mohammadgholi, Nourollah Sadeghzadeh, Mostafa Erfani, Saeid Abediankenari, Seyed Mohammad Abedi, Iman Emrarian, Narjes Jafari, Ramezan Behzadi
BACKGROUND: Human fibronectin extra-domain B (EDB) is particularly expressed during angiogenesis progression. It is, thus, a promising marker of tumour growth. Aptides are a novel class of peptides with high-affinity binding to specific protein targets. APTEDB is an antagonist-like ligand that especially interacts with human fibronectin EDB. OBJECTIVE: This study was the first attempt in which the hydrazinonicotinamide (HYNIC)-conjugated APTEDB was labelled with technetium-99m (99mTc) as an appropriate radiotracer and tricine/EDDA exchange labeling ...
September 18, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28884339/altered-expression-of-circadian-clock-genes-in-polyglandular-autoimmune-syndrome-type-iii
#13
Anna Angelousi, Narjes Nasiri-Ansari, Eliana Spilioti, Emilia Mantzou, Vasiliki Kalotyxou, George Chrousos, Gregory Kaltsas, Eva Kassi
PURPOSE: Circadian timing system is a highly conserved, ubiquitous molecular "clock" which creates internal circadian rhythmicity. Dysregulation of clock genes expression is associated with various diseases including immune dysregulation. In this study we investigated the circadian pattern of Clock-related genes in patients with polyglandular autoimmune syndrome type III (PAS type III). METHODS: Nineteen patients diagnosed with PAS type III and 12 healthy controls were enrolled...
September 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28759882/oculomotricity-and-neurological-soft-signs-can-we-refine-the-endophenotype-a-study-in-subjects-belonging-to-the-spectrum-of-schizophrenia
#14
Simona Caldani, Isabelle Amado, Narjes Bendjemaa, François Vialatte, Célia Mam-Lam-Fook, Raphael Gaillard, Marie-Odile Krebs, Maria Pia Bucci
Alterations in eye tracking and motor impairments as well as Neurological Soft Signs (NSS) are frequently reported in patients with schizophrenia as well as in their relatives, and are proposed as endophenotype of the disease. This study investigated smooth pursuit eye movement and fixation task with distractors with a gap condition, two markers of inhibitory control mechanism, in 49 patients with schizophrenia, 24 ultra-high risk subjects, 41 full biological clinical siblings of patients and 48 controls. NSS were assessed as a marker of abnormal neurodevelopment...
June 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28754766/divergent-evolution-and-niche-differentiation-within-the-common-peatmoss-sphagnum-magellanicum
#15
Narjes Yousefi, Kristian Hassel, Kjell Ivar Flatberg, Petri Kemppainen, Emiliano Trucchi, A Jonathan Shaw, Magni Olsen Kyrkjeeide, Péter Szövényi, Hans K Stenøien
PREMISE OF THE STUDY: Populations with phenotypic polymorphism in discrete characters may be good models for investigating genome evolution and speciation. Sphagnum magellanicum Brid. is found throughout the northern hemisphere, and despite considerable variation in morphological characters, it is considered one of the least taxonomically controversial peatmoss species. We have observed two main morphs of the species associated with different microhabitats. Here we investigated the genomic and environmental basis of this intraspecific morphological variation...
July 28, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28748171/effect-of-linalool-on-the-acquisition-and-reinstatement-of-morphine-induced-conditioned-place-preference-in-mice
#16
Narjes Pourtaqi, Mohsen Imenshahidi, Bibi Marjan Razavi, Hossein Hosseinzadeh
OBJECTIVE: The effect of linalool, a terpene alcohol found in many plants, which inhibits NMDA receptors, on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) was evaluated in mice. MATERIAL AND METHODS: The effects of different doses of linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg, an NMDA receptor antagonist) and saline, in CPP induced by 40 mg/kg of morphine were investigated in mice. In another experiment, a single injection of morphine (10 mg/kg) reinstated the place reference following extinction of a place preference induced by morphine (40 mg/kg)...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28745903/trend-of-socio-demographic-index-and-mortality-estimates-in-iran-and-its-neighbors-1990-2015-findings-of-the-global-burden-of-diseases-2015-study
#17
Maziar Moradi-Lakeh, Sadaf G Sepanlou, Seyed M Karimi, Narjes Khalili, Shirin Djalalinia, Chante Karimkhani, Kristopher Krohn, Ashkan Afshin, Farshad Farzadfar, Aliasghar Ahmad Kiadaliri, Mohsen Asadi-Lari, Hamid Asayesh, Ali Reza Esteghamati, Maryam S Farvid, Seyed-Mohammad Fereshtehnejad, Pouria Heydarpour, Ardeshir Khosravi, Jagdish Khubchandani, Amir Kasaeian, Saleem M Rana, Mahdi Mahdavi, Habib Masoudifarid, Alireza Mohammadi, Farshad Pourmalek, Mostafa Qorbani, Amir Radfar, Kazem Rahimi, Vafa Rahimi-Movaghar, Gholamreza Roshandel, Sare Safi, Payman Salamati, Arash Tehrani-Banihashemi, Shahrzad Bazargan-Hejazi, Theo Vos, Reza Malekzadeh, Ali H Mokdad, Christopher J L Murray, Mohsen Naghavi
BACKGROUND: The Global burden of disease and injuries study (GBD 2015) reports expected measures for years of life lost (YLL) based on socio-demographic index (SDI) of countries, as well as the observed measures. In this extended GBD 2015 report, we reviewed total and cause-specific deaths and YLL for Iran and all its neighboring countries between 1990 and 2015. METHODS: We extracted data from the GBD 2015 database. Observed YLL measures were calculated by multiplying the number of deaths by standard life expectancy at each age...
July 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28717128/mother-s-pre-pregnancy-bmi-and-placental-candidate-mirnas-findings-from-the-environage-birth-cohort
#18
Maria Tsamou, Dries S Martens, Ellen Winckelmans, Narjes Madhloum, Bianca Cox, Wilfried Gyselaers, Tim S Nawrot, Karen Vrijens
There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child's predisposition to develop disease later in life. The aim of this study is to investigate the association between maternal pre-pregnancy body mass index (BMI) and miRNA alterations in placental tissue at birth. In 211 mother-newborn pairs from the ENVIRONAGE birth cohort, we assessed placental expression of seven miRNAs important in crucial cellular processes implicated in adipogenesis and/or obesity...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698861/spiritual-therapy-in-coping-with-cancer-as-a-complementary-medical-preventive-practice
#19
REVIEW
Abolfazl Movafagh, Mohammad Hassan Heidari, Morteza Abdoljabbari, Neda Mansouri, Afsoon Taghavi, Aliasghar Karamatinia, Narjes Mehrvar, Mehrdad Hashemi, Mona Ghazi
There are many of methods of treating cancer. However, the concept of curing the cancer is beyond our current knowledge. Some patients who have the cancer may seek an alternative manner of curing their disease. Alternative medicines, such as spiritual and complementary therapy, are able to cure the cancer and, at the least, are safe. Research on the importance of spirituality in cancer care has mainly been performed in geographically heterogeneous populations. The results are limited to these specific religious-cultural contexts and enlightened by contributions from ethnicity and religion...
June 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28698860/genomic-profiling-of-chronic-myelogenous-leukemia-basic-and-clinical-approach
#20
REVIEW
Aliasghar Keramatinia, Alireza Ahadi, Mohammad Esmaeil Akbari, Maryam Mohseny, Alireza Mosavi Jarahi, Narjes Mehrvar, Neda Mansouri, S A Mortazavi Tabatabaei, Abolfazl Movafagh
Chronic myeloid leukemia (CML) is a hematological stem cell cancer driven by BCR-ABL1 fusion protein. We review the previous and recent evidence on the significance of CML in diagnostic and clinic management. The technical monitoring of BCR-ABL1 with quantitative real time-PCR has been used in assessing patient outcome. The cytogenetic mark of CML is Philadelphia chromosome, that is formed by reciprocal chromosomal translocations between human chromosome 9 and 22, t(9:22) (q(34):q(11)). It makes a BCR-ABL1 fusion protein with an anomaly tyrosine kinase activity that promotes the characteristic proliferation of progenitor cells in CML and acute lymphoblastic lymphoma...
June 2017: Journal of Cancer Prevention
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