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https://www.readbyqxmd.com/read/28222506/synaptic-compensation-as-a-probable-cause-of-prolonged-mild-cognitive-impairment-in-alzheimer-s-disease-implications-from-a-transgenic-mouse-model-of-the-disease
#1
Narjes Baazaoui, Michael Flory, Khalid Iqbal
Alzheimer's disease (AD) is a slow, progressive neurodegenerative disease in which cognitive decline takes place over a period of several years with a very variable period of mild cognitive impairment (MCI) and, in some cases, relatively long period before progression to dementia. The cognitive deficit during MCI is probably due to neuronal loss, an intermediate level of amyloid-β (Aβ) plaques and neurofibrillary tangles (NFT) and synaptosis, which is interrupted with a transient compensatory increase. We found impairment in reference memory accompanied by a decrease in the expression of synaptophysin, β-III tubulin, and MAP2 and a trend for GluR1, at 12 weeks of age in 3xTg-AD mice (hAPPSwe, P301L tau, PS1 [M146V] knock-in), a widely used transgenic model of AD...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28220266/interpretation-of-cardiac-wall-motion-from-cine-mri-combined-with-parametric-imaging-based-on-the-hilbert-transform
#2
Narjes Benameur, Enrico Gianluca Caiani, Younes Arous, Nejmeddine Ben Abdallah, Tarek Kraiem
OBJECT: The aim of this study was to test and validate the clinical impact of parametric amplitude images obtained using the Hilbert transform on the regional interpretation of cardiac wall motion abnormalities from cine-MR images by non-expert radiologists compared with expert consensus. MATERIALS AND METHODS: Cine-MRI short-axis images obtained in 20 patients (10 with myocardial infarction, 5 with myocarditis and 5 with normal function) were processed to compute a parametric amplitude image for each using the Hilbert transform...
February 20, 2017: Magma
https://www.readbyqxmd.com/read/28213221/a-novel-fluorescent-aptasensor-for-ultrasensitive-detection-of-microcystin-lr-based-on-single-walled-carbon-nanotubes-and-dapoxyl
#3
Seyed Mohammad Taghdisi, Noor Mohammad Danesh, Mohammad Ramezani, Narjes Ghows, Seyed Ali Mousavi Shaegh, Khalil Abnous
To assure water safety and protect human health, precise and simple analytical approaches are highly desired to determine low concentrations of microcystin-leucine-arginine (MC-LR), a toxin, in both water and serum samples. Herein, a simple, rapid and accurate aptamer-based fluorescent sensor was used for selective recognition of MC-LR, based on single-walled carbon nanotubes (SWNTs) as immobilizers, dapoxyl as a fluorescent dye, DAP-10 as a specific aptamer for dapoxyl and unmodified MC-LR aptamer (Apt) as a sensing ligand...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213016/walking-dead-permeabilization-of-heat-treated-geobacillus-stearothermophilus-atcc-12980-spores-under-growth-preventing-conditions
#4
Narjes Mtimet, Clément Trunet, Anne-Gabrielle Mathot, Laurent Venaille, Ivan Leguérinel, Louis Coroller, Olivier Couvert
Although heat treatment is probably the oldest and the most common method used to inactivate spores in food processes, the specific mechanism of heat killing of spores is still not fully understood. The purpose of this study is to investigate the evolution of the permeabilization and the viability of heat-treated spores during storage under growth-preventing conditions. Geobacillus stearothermophilus spores were heat-treated under various conditions of temperature and pH, and then stored under conditions of temperature and pH that prevent growth...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28203452/observation-in-grounded-theory-and-ethnography-what-are-the-differences
#5
Tahereh Fathi Najafi, Robab Latifnejad Roudsari, Hossein Ebrahimipour, Narjes Bahri
No abstract text is available yet for this article.
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28203324/lived-experience-of-caregivers-of-family-centered-care-in-the-neonatal-intensive-care-unit-evocation-of-being-at-home
#6
Zahra Hadian Shirazi, Farkhondeh Sharif, Mahnaz Rakhshan, Narjes Pishva, Faezeh Jahanpour
BACKGROUND: In recent decades, family-centered care (FCC) has come to be known, accepted, and reported as the best care strategy for admitted children and their families. However, in spite of the increasing application of this approach, the experiences of the caregivers have not yet been studied. OBJECTIVES: The present study aimed at the description and interpretation of the FCC experience in two neonatal intensive care units (NICU) at Shiraz University of Medical Sciences...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28161846/genotypic-analysis-of-virulence-genes-and-antimicrobial-profile-of-diarrheagenic-escherichia-coli-isolated-from-diseased-lambs-in-iran
#7
Reza Ghanbarpour, Nasrin Askari, Masoud Ghorbanpour, Yahya Tahamtan, Khoobyar Mashayekhi, Narjes Afsharipour, Nasim Darijani
The aim of the present study was to determine the analysis of virulence genes and antimicrobial profile of diarrheagenic Escherichia coli isolated from diseased lambs. Two hundred ninety E. coli isolates were recovered from 300 rectal swabs of diarrheic lambs and were confirmed by biochemical tests. The pathotype determination was done according to the presence of genes including f5, f41, LTI, STI, bfp, ipaH, stx 1 , stx 2 , eae, ehlyA, cnf 1 , cnf 2 , cdIII, cdIV, and f17 by PCR method. Sixty-six isolates (23...
February 4, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28101472/the-effects-of-hypoxia-on-u937-cell-line-in-mesenchymal-stem-cells-co-culture-system
#8
Mostafa Ejtehadifar, Karim Shamsasenjan, Parvin Akbarzadehlaleh, Sarah Zahedi, Narjes Kazemi
Purpose: Mesenchymal Stem Cells (MSCs) are the most important members of Bone Marrow (BM) milieu. MSCs affect different kinds of cells, particularly malignant cells of hematologic malignancies, but the effects of MSCs are unclear exactly. Here we analyzed the effects of derived Umbilical Cord Blood-MSCs on proliferation, cell death and some surface markers of U937 cell line in a Co-culture system with MSCs. Methods: Here we designed Co-culture systems as a model of BM milieu. We cultured U937 cells on UCB-MSCs and MSCs Conditioned Medium (C...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28089960/cohort-profile-the-environmental-influence-on-early-ageing-environage-a-birth-cohort-study
#9
Bram G Janssen, Narjes Madlhoum, Wilfried Gyselaers, Esmée Bijnens, Diana B Clemente, Bianca Cox, Janneke Hogervorst, Leen Luyten, Dries S Martens, Martien Peusens, Michelle Plusquin, Eline B Provost, Harry A Roels, Nelly D Saenen, Maria Tsamou, Annette Vriens, Ellen Winckelmans, Karen Vrijens, Tim S Nawrot
No abstract text is available yet for this article.
January 15, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28089135/phenotypic-continuum-between-autism-and-schizophrenia-evidence-from-the-movie-for-the-assessment-of-social-cognition-masc
#10
Gilles Martinez, Charlotte Alexandre, Célia Mam-Lam-Fook, Narjes Bendjemaa, Raphaël Gaillard, Patricia Garel, Isabel Dziobek, Isabelle Amado, Marie-Odile Krebs
Schizophrenic (SCZ) and autism (ASD) spectrum disorders share several features including social cognition impairments. In SCZ, the link between symptomatic dimensions and social cognition deficits remains unclear. The Movie for the Assessment of Social Cognition (MASC) test, available in several languages including English, investigates mental state attribution capabilities in complex interpersonal situations. After its translation into French, we used MASC to direct compare social cognition in 36 young participants with SCZ to 19 with ASD and 20 healthy controls (HC) matched for gender, age (18-25y...
January 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28070252/study-of-functional-vulnerability-status-of-tehran-hospitals-in-dealing-with-natural-disasters
#11
Batol Ahmadi, Abbas Rahimi Foroushani, Narjes Tanha, Amjad Mohamadi Bolban Abad, Heshmatollah Asadi
INTRODUCTION: At the time of disasters, hospitals are considered as one of the most important facilities which should provide emergency services continuously. The purpose of this study was to determine the functional vulnerability of Tehran hospitals in dealing with natural disasters. METHODS: This cross-sectional study was conducted in educational hospitals of Tehran University of Medical Science (TUMS), in 2013. Of all 26 hospitals, 12 hospitals were selected through single-stage cluster sampling, including six general (Shariati, Amiralam, Sina, Imam, Hazrat Rasoul, Baharlou) and six specialized (Bahrami, Hazrat-e Aliasghar, Shahid rajaie, Roozbeh, Moheb yas, Children Medical Center) hospitals...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28045677/vitamin-d-affects-glucocorticoid-action-in-target-cells
#12
EDITORIAL
Eva Kassi, Narjes Nasiri-Ansari, Athanasios G Papavassiliou
No abstract text is available yet for this article.
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28008384/circulating-cytokeratin-positive-cells-and-tumor-budding-in-colorectal-cancer
#13
Bruno Märkl, Narjes Wilhelms, Matthias Anthuber, Gerhard Schenkirsch, Günter Schlimok, Daniel Oruzio
AIM: To investigate whether circulating cytokeratin-positive (CK(+)) cells in the mesenteric blood of resected colorectal specimens are prognostic and correlate with tumor budding. METHODS: Fifty-six colorectal specimens were collected between 9/2007 and 7/2008. Blood from the mesenteric vein was drawn immediately after receiving the fresh and unfixed specimens in the pathology department. After separation of the mononuclear cells by Ficoll-Hypaque density-gradient centrifugation, cytological smears were immunocytochemically stained for CK18...
December 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27994261/use-of-cardiopulmonary-bypass-for-management-of-massive-air-embolism-during-hysteroscopic-metroplasty
#14
Ahmad Ali Amirghofran, Narjes Nick, Mina Amiri, Rahim Hemmati
The patient was a 32-year-old woman who presented with infertility secondary to uterine didelphys. Hysteroscopic metroplasty was chosen as the corrective surgical procedure for this anatomical defect. During the surgical repair, the patient developed a massive air embolism (MAE) leading to hypotension, arrhythmia, and cardiogenic shock. Resuscitation was started by placing the patient in the right-side up position, and emplacement of central venous catheter, but it was unsuccessful. The decision was then made to bypass the patient's cardiopulmonary system to effectively treat the MAE...
December 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27929096/enhancing-steel-properties-through-in-situ-formation-of-ultrahard-ceramic-surface
#15
Farshid Pahlevani, Rahul Kumar, Narjes Gorjizadeh, Rumana Hossain, Sagar T Cholake, Karen Privat, Veena Sahajwalla
Abrasion and corrosion resistant steel has attracted considerable interest for industrial application as a means of minimising the costs associated with product/component failures and/or short replacement cycles. These classes of steels contain alloying elements that increase their resistance to abrasion and corrosion. Their benefits, however, currently come at a potentially prohibitive cost; such high performance steel products are both more technically challenging and more expensive to produce. Although these methods have proven effective in improving the performance of more expensive, high-grade steel components, they are not economically viable for relatively low cost steel products...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924658/the-relationship-between-functional-ovarian-cysts-and-vitamin-a-vitamin-e-and-folate-intake
#16
Mahin Tafazoli, Elham Fazeli, Mohsen Nematy, Narjes Bahri, Salmeh Dadgar
This study aimed to clarify the relationship between functional ovarian cysts and vitamin A, vitamin E, and folate intake. This case-control study evaluated 265 women of reproductive age who presented at gynaecology clinics of three hospitals in Mashhad, Iran. While women in the ovarian cyst group [n = 132] had functional ovarian cysts, control group [n = 133] consisted of women without functional ovarian cysts. The participants' vitamin A, vitamin E, and folate intake was assessed using the Food Frequency Questionnaire...
December 7, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27847695/combined-ketamine-tramadol-subcutaneous-wound-infiltration-for-multimodal-postoperative-analgesia-a-double-blinded-randomized-controlled-trial-after-renal-surgery
#17
Mohammad Reza Khajavi, Marzieh Navardi, Reza Shariat Moharari, Pejman Pourfakhr, Narjes Khalili, Farhad Etezadi, Farsad Imani
BACKGROUND: Pain is an important consideration after renal surgery. A multimodal approach to postoperative pain management could enhance analgesia by risking fewer side effects after surgery. OBJECTIVES: The aim of this study was to evaluate the clinical efficacy of the subcutaneous infiltration of ketamine and tramadol at the incision site to reduce postoperative pain. METHODS: Sixty-four patients between 18 and 80 years old who were scheduled for elective renal surgery were enrolled in a double-blind randomized controlled study...
October 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27814242/neonatal-cord-blood-oxylipins-and-exposure-to-particulate-matter-in-the-early-life-environment-an-environage-birth-cohort-study
#18
Dries S Martens, Sandra Gouveia, Narjes Madhloum, Bram G Janssen, Michelle Plusquin, Charlotte Vanpoucke, Wouter Lefebvre, Bertil Forsberg, Malin Nording, Tim S Nawrot
BACKGROUND: As part of the lipidome, oxylipins are bioactive lipid compounds originating from oxidation of different fatty acids. Oxylipins could provide a new target in the developmental origins model or the ability of early life exposure to change biology. OBJECTIVES: We studied the association between in utero PM2.5 (particulate matter with aerodynamic diameter <2.5µm) exposure and oxylipin profiles in newborns. METHODS: Thirty-seven oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15-LOX) and cytochrome P450 (CYP) pathways were assayed in 197 cord blood plasma samples from the ENVIRONAGE birth cohort...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27797271/histological-evaluation-of-follicular-delivery-of-arginine-via-nanostructured-lipid-carriers-a-novel-potential-approach-for-the-treatment-of-alopecia
#19
Seyedeh Narjes Yazdani-Arazi, Saeed Ghanbarzadeh, Khosro Adibkia, Maryam Kouhsoltani, Hamed Hamishehkar
The use of lipidic nanoparticles can overcome the limitations of skin penetration of hydrophilic charged materials. Oleic acid as an ion pairing agent was used to enhance the encapsulation of positively charged arginine into lipophilic nanostructured lipid carrier (NLC). Histological study on the male hamsters was performed to assess the efficiency of drug delivery on hair growth. The accumulation of NLCs in the hair follicles was verified and in vivo studies showed more new hair follicle growth by utilizing arginine-loaded NLCs than arginine aqueous solution...
October 31, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27790351/predictors-of-prenatal-empowerment-among-iranian-pregnant-women
#20
Narjes Sadat Borghei, Ali Taghipour, Robab Latifnejad Roudsari, Afsaneh Keramat, Hadi Jabbari Noghabi
INTRODUCTION: Considering that empowering expectant mothers is an important issue to maintain a healthy pregnancy, this study was conducted to evaluate the predictors of empowerment among Iranian pregnant women. METHODS: This cross sectional study was conducted in Golestan, North of Iran in 2015. A total number of 161 pregnant women were selected through random cluster sampling from urban health centers, using PASS software. The socio-political, educational, and mental-financial predictors of empowerment were measured using a self-structured questionnaire during pregnancy and was analyzed by a linear regression model using SPSS version 16...
September 2016: Electronic Physician
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