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Spine injections

Amirali Toossi, Dirk G Everaert, Peter Seres, Jacob L Jaremko, Kevin Robinson, C Chris Kao, Peter E Konrad, Vivian K Mushahwar
OBJECTIVE The overall goal of this study was to develop an image-guided spinal stereotactic setup for intraoperative intraspinal microstimulation (ISMS). System requirements were as follows: 1) ability to place implants in various segments of the spinal cord, targeting the gray matter with a < 0.5-mm error; 2) modularity; and 3) compatibility with standard surgical tools. METHODS A spine-mounted stereotactic system was developed, optimized, and tested in pigs. The system consists of a platform supporting a micromanipulator with 6 degrees of freedom...
June 15, 2018: Journal of Neurosurgery. Spine
Meaghan A O'Reilly, Tricia Chinnery, My-Linh Yee, Sheng-Kai Wu, Kullervo Hynynen, Robert S Kerbel, Gregory J Czarnota, Kathleen I Pritchard, Arjun Sahgal
Leptomeningeal metastases (LM) are a serious complication of cancer in the central nervous system (CNS) and are diagnosed in approximately 5% of patients with solid tumors. Effective treatment using systemically administered therapeutics is hindered by the barriers of the CNS. Ultrasound can mediate delivery of drugs through these barriers. The goal of this study was to test the feasibility of using ultrasound-mediated drug delivery to improve the treatment of LM. LM was induced in the spinal cord of athymic rats by injecting HER2-expressing breast cancer cells into the subarachnoid space of the thoracic spine...
June 13, 2018: Scientific Reports
Dong Wook Lim, Taewon Han, Jonghoon Jung, Yuri Song, Min Young Um, Minseok Yoon, Yun Tai Kim, Seungmok Cho, In-Ho Kim, Daeseok Han, Changho Lee, Jaekwang Lee
SCOPE: Oxidative stress has been implicated in mental disorders, including depression. Chlorogenic acid (CGA), a phenolic compound abundant in herbs and fruits, has been reported to have antioxidant and free-radical scavenging properties. In this study, we investigated the antidepressant-like effects and active mechanisms of CGA from the extract of Crataegus pinnatifida (CP) fruit. METHODS AND RESULTS: Depression-like phenotypes were induced in mice by daily injection of stress hormone for 1-2 weeks...
June 12, 2018: Molecular Nutrition & Food Research
Li Jin, Lin Li, Guo-Yong Li, Sha Liu, Dan-Ju Luo, Qiong Feng, Dong-Sheng Sun, Wei Wang, Jian-Yun Liu, Qun Wang, Dan Ke, Xi-Fei Yang, Gong-Ping Liu
Epidemiological surveys show that 70-80% of patients with Alzheimer's disease (AD) have type 2 diabetes mellitus (T2DM) or show an abnormality of blood glucose levels. Therefore, an increasing number of evidence has suggested that diabetic hyperglycemia is tightly linked with the pathogenesis and progression of AD. In the present study, we replicated T2DM animal model via subcutaneous injection of newborn Sprague-Dawley (SD) rats with monosodium glutamate (MSG) during the neonatal period to investigate the effects and underlying mechanisms of hyperglycemia on cognitive ability...
June 6, 2018: Neuroscience Letters
Theresa Krätzig, Marc Dreimann, Klaus Christian Mende, Ingo Königs, Manfred Westphal, Sven Oliver Eicker
BACKGROUND: Spinal adhesive arachnoiditis (SAA) is an inflammatory process of the meninges. Cystic changes and cicatrisation may lead to neurological deficits and immobilization. Therapy is difficult and often unsatisfactory. We describe eight cases of extensive SAA following extradural spinal infection. METHODS: 238 patients with epidural abscess or osteomyelitis were treated at our institution between 2011 and 2018. We identified eight patients who developed extensive SAA on follow-up...
June 5, 2018: World Neurosurgery
Hui Zhang, Jun Xuan, Tian-He Chen, Ze-Xin Chen, Liao-Jun Sun, Nai-Feng Tian, Xiao-Lei Zhang, Xiang-Yang Wang, Yan Lin, Yao-Sen Wu
PURPOSE: To measure the projection of the most anterior line of the spinal canal on lateral radiographs of the vertebra (C3-L5) and evaluate the efficacy of the safety line (SL) in preventing intraspinal cement leakage in percutaneous kyphoplasty (PKP) and percutaneous vertebroplasty (PVP). MATERIALS AND METHODS: Fifteen adult dry-bone spine specimens were analyzed. The projection of the SL was viewed on lateral radiographs. The distance between the SL and the posterior vertebral body line (PVBL) was measured...
June 8, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Richard Saitz, Aldina Mesic, Alicia S Ventura, Michael R Winter, Timothy C Heeren, Meg M Sullivan, Alexander Y Walley, Gregory J Patts, Seville M Meli, Michael F Holick, Theresa W Kim, Kendall J Bryant, Jeffrey H Samet
BACKGROUND: People living with HIV (PLWH) commonly have low bone mineral density (BMD) (low bone mass and osteoporosis) and are at high risk for fractures. Fractures and low BMD are significant causes of morbidity and mortality, increasingly relevant as PLWH age. Alcohol use is common among PLWH and known to affect bone health. The association between alcohol use and changes in BMD among PLWH is not well understood. METHODS: We conducted a 3.5-year prospective cohort study of 250 PLWH with substance use disorder or ever injection drug use...
June 6, 2018: Alcoholism, Clinical and Experimental Research
Tim Hahn, Marc-Eric Halatsch, Christian Wirtz, Stephan Klessinger
BACKGROUND: Among the various causes of vertigo, the so-called cervicogenic vertigo (CV) has been the most controversial. However, perturbations of proprioceptive signals and abnormal activity of the cervical afferents can induce vertigo. Medial branch blocks (MBBs) are a diagnostic tool designed to test whether a patient's neck pain is mediated by one or more of the medial branches of the dorsal rami of the spinal nerve. It is unknown whether MBBs are also suitable for testing symptoms other than pain...
May 2018: Pain Physician
Amanda J Sales, Manoela V Fogaça, Ariandra G Sartim, Vitor S Pereira, Gregers Wegener, Francisco S Guimarães, Sâmia R L Joca
Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic component of Cannabis sativa, is a promising compound since it shows large-spectrum therapeutic potential in preclinical models and humans. However, its antidepressant properties have not been completely investigated. Therefore, the aims of this study were to investigate in male rodents (i) whether CBD could induce rapid and sustained antidepressant-like effects after a single administration and (ii) whether such effects could be related to changes in synaptic proteins/function...
June 4, 2018: Molecular Neurobiology
Hong-Bin Luo, Nan Shang, Wen-Zhi Xie, De-Jian Wen, Min Qu, Sheng Huang, Sha-Sha Fan, Wei Chen, Nan-Qiao Mou, Xiang-Yu Liu, Qin Chen, Feng-Feng Xie, Jun-Xu Li
Large-scale epidemiological studies have found that hyperhomocysteinemia is a powerful, independent risk factor for Alzheimer's disease. Trillium tschonoskii maxim is a traditional Chinese medicine that is used to promote memory. However, scientific understanding of its mechanism of action is limited. This report studied the potential neuroprotective effects of Trillium tschonoskii maxim extract against homocysteine-induced cognitive deficits. Rats were intravenously injected with homocysteine (400 μg/kg) for 14 days to induce a model of Alzheimer's disease...
May 2018: Neural Regeneration Research
Sade Spencer, Daniela Neuhofer, Vivian C Chioma, Constanza Garcia-Keller, Danielle J Schwartz, Nicholas Allen, Michael D Scofield, Tara Ortiz-Ithier, Peter W Kalivas
BACKGROUND: Cannabis is the most widely used illicit drug, but knowledge of the neurological consequences of cannabis use is deficient. Two primary components of cannabis are Δ9 -tetrahydrocannabinol (THC) and cannabidiol (CBD). We established a THC+CBD model of self-administration and reinstated drug seeking to determine if, similar to other addictive drugs, cannabis produces enduring synaptic changes in nucleus accumbens core (NAcore) thought to contribute vulnerability to drug reinstatement...
May 3, 2018: Biological Psychiatry
Tao Wu, Hai Nie, Allan B Dietz, David R Salek, Jay Smith, Andre J van Wijnen, Wenchun Qu
BACKGROUND: Transplantation of mesenchymal stem cells (MSCs) is a promising therapy for degenerative spine conditions. However, cell therapy for painful spine degeneration presently requires use of contrast agents during fluoroscopy-guided injections and the effects of these agents on MSCs represents a gap in knowledge. OBJECTIVE: To investigate the biological effects of contrast media that are co-injected with MSCs. DESIGN: Prospective observational study...
May 31, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
Gregory D Schroeder, Mark F Kurd, Christopher K Kepler, Kris E Radcliff, Mitchell G Maltenfort, Hamadi Murphy, Jeffery A Rihn, D Greg Anderson, Alan S Hilibrand, Alexander R Vaccaro
STUDY DESIGN: Retrospective case-control study. BACKGROUND: Physician-owned specialty hospitals focus on taking care of patients with a select group of conditions. In some instances, they may also create a potential conflict of interest for the surgeon. The effect this has on the surgical algorithm for patients with degenerative cervical spine conditions has not been determined. METHODS: A retrospective review of all patients who underwent a 1- or 2-level anterior cervical discectomy and fusion between October 2009 and December 2014 at either a physician-owned specialty hospital or an independently owned community hospital were identified...
June 2018: Clinical Spine Surgery
Sherveen N Parivash, Peter G Kranz, Linda Gray, Timothy J Amrhein
OBJECTIVE: The purpose of this study was to assess the rate of inadvertent injection into the retrodural space of Okada during CT fluoroscopy-guided interlaminar epidural steroid injection in the cervical spine. MATERIALS AND METHODS: Images from cases of cervical interlaminar epidural steroid injection under CT fluoroscopic guidance performed at a single institution between November 2009 and November 2015 were obtained and reviewed. For all cases, the following information was recorded: presence or absence of contrast material within the Okada space, cervical anatomic level at which the procedure was performed, laterality of approach, trainee presence, and years of proceduralist experience...
May 29, 2018: AJR. American Journal of Roentgenology
Michael B Furman, Stephen C Johnson
BACKGROUND CONTEXT: Lumbosacral radicular symptoms are commonly evaluated in clinical practice. Level specific diagnosis is crucial for management. Clinical decisions are often made by correlating a patient's symptom distribution and imaging with sensory dermatomal maps. It is not uncommon for patients to describe non-dermatomal symptom patterns or for imaging to demonstrate pathology at levels not predicted by a dermatomal map. These observations suggest that the referred symptom distribution from lumbosacral nerve root provocation is different from dermatomal maps...
May 22, 2018: Spine Journal: Official Journal of the North American Spine Society
Dimitrios K Filippiadis, Stefano Marcia, Anthony Ryan, Douglas P Beall, Salvatore Masala, Frederic Deschamps, Alexis Kelekis
Vertebral compression fractures (VCFs) may result in a kyphotic deformity which can cause potential systemic complications secondary to respiratory and gastrointestinal dysfunction. The use of implants in the spine for VCF treatment represents a paradigm shift away from cement injection on its own, aiming to combine the analgesic and stabilizing effect of injecting cement into the vertebral body with vertebral height restoration and kyphotic angle correction. Spine implants which can be used for VCF treatment include stents, jacks, PEEK cages and fracture reduction systems...
May 22, 2018: Cardiovascular and Interventional Radiology
Petr Rehousek, Edward Jenner, James Holton, Marcin Czyz, Lukas Capek, Petr Henys, Marketa Kulvajtova, Martin Krbec, Jiri Skala-Rosenbaum
Background Context Odontoid process fractures are the most common injuries of the cervical spine in the elderly. Anterior screw stabilisation of type 2 odontoid process fractures improves survival and function in these patients but may be complicated by failure of fixation. Purpose To determine whether cement augmentation of a standard anterior screw provides biomechanically superior fixation of type II odontoid fractures in comparison to a non-cemented standard screw. Study design Twenty human cadaveric C2 vertebrae from elderly donors (mean age 83 years) were obtained...
May 18, 2018: Spine Journal: Official Journal of the North American Spine Society
Caroline A Burgard, Julien Dinkel, Frederik Strobl, Philipp M Paprottka, Nicolai Schramm, Maximilian Reiser, Christoph G Trumm
PURPOSE: We aimed to assess the safety and technical outcome of computed tomography (CT) fluoroscopy-guided osteoplasty with or without prior percutaneous radiofrequency ablation (RFA) in patients with painful osteolyses. METHODS: We performed a retrospective analysis of 29 patients with painful extraspinal and spinal osteolyses (16 women, 13 men; 63.1±14.4 years) who underwent CT fluoroscopy-guided osteoplasty (10-20 mAs tube current) with or without RFA (26 and 14 lesions, respectively), in 33 consecutive procedures from 2002 to 2016...
May 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Adrian Popescu, Jaymin Patel, Zachary L McCormick, Timothy P Maus, Meghan Rodes, David R Walega, Clark C Smith
No abstract text is available yet for this article.
May 14, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Mika Soma, Jonghyuk Kim, Asami Kato, Suguru Kawato
Dendritic spine is a small membranous protrusion from a neuron's dendrite that typically receives input from an axon terminal at the synapse. Memories are stored in synapses which consist of spines and presynapses. Rapid modulations of dendritic spines induced by hippocampal sex steroids, including dihydrotestosterone (DHT), testosterone (T), and estradiol (E2), are essential for synaptic plasticity. Molecular mechanisms underlying the rapid non-genomic modulation through synaptic receptors of androgen (AR) and estrogen (ER) as well as its downstream kinase signaling, however, have not been well understood...
2018: Frontiers in Neuroscience
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