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https://www.readbyqxmd.com/read/29026370/preliminary-molecular-characterization-of-a-proinflammatory-and-nociceptive-molecule-from-the-echinometra-lucunter-spines-extracts
#1
Juliana Mozer Sciani, Bianca Zychar, Luis Roberto Gonçalves, Renata Giorgi, Thiago Nogueira, Daniel Carvalho Pimenta
BACKGROUND: Sea urchins are animals commonly found on the Brazilian shoreline, being Echinometra lucunter the most abundant species. Accidents caused by E. lucunter have been reported as one of the most frequent in Brazil, and are characterized by intense pain and inflammation, consequence of spine puncture in the skin. In order to characterize such toxic effects, we isolated one molecule that caused inflammatory and nociceptive effects. METHODS: E. lucunter specimens were collected without gender distinction...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29019641/spine-conditions-lumbar-spinal-stenosis
#2
Steven D Trigg, Zachary Devilbiss
Lumbar spinal stenosis (LSS) is a frequent cause of chronic low back and lower extremity pain in older patients. Symptomatic LSS typically is described as neurogenic claudication consisting of pain, weakness, numbness, and/or fatigue arising in the back and radiating into the buttock, thigh, or lower leg. The diagnosis is complicated by lack of reliable clinical or x-ray criteria. North American Spine Society guidelines recommend magnetic resonance imaging study without contrast to confirm anatomic narrowing of the spinal canal or nerve root impingement...
October 2017: FP Essentials
https://www.readbyqxmd.com/read/29018405/chimeric-peptide-tat-ha-nr2b9c-improves-regenerative-repair-after-transient-global-ischemia
#3
Hai-Hui Zhou, Li Zhang, Hai-Xia Zhang, Jin-Ping Zhang, Wei-Hong Ge
Transient global ischemia (TGI) is a major public health problem, and it heightens the need of effective treatments. The present study was undertaken to investigate whether recombinant polypeptide Tat-HA-NR2B9c improves spatial learning and memory deficits in rats after TGI. Rats were subjected to 20-min ischemia induced by four-vessel occlusion (4-VO) method and daily injected with Tat-HA-NR2B9c (1.12 mg/kg) for 1 week. Tat-HA-NR2B9c increased CREB activity, upregulated B-cell lymphoma-2 (Bcl-2) expression after treated for 24 h...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29016932/systemic-effects-of-epidural-corticosteroid-injection
#4
Wade King, David C Miller, Clark C Smith
No abstract text is available yet for this article.
July 20, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29016866/anesthetic-test-dose-and-seizure-risk-with-cervical-transforaminal-epidural-steroid-injection
#5
Fred DeFrancesch, David O'Brien, Clark C Smith
No abstract text is available yet for this article.
July 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28987657/feasibility-of-percutaneous-cryoablation-of-vertebral-metastases-under-local-anaesthesia-in-asaiii-patients
#6
Alessandro Motta, Giuseppe Caltabiano, Stefano Palmucci, Giovanni Failla, Antonio Basile
PURPOSE: spine metastases are common concern from several primary neoplasms, modern management include percutaneous techniques such as ablation and cementoplasty. This research aims to evaluate the treatment under local anaesthesia in high-risk patients (ASA III). METHODS AND MATERIAL: from January 2013 up to September 2016 we treated via percutaneous cryoablation 11 advanced oncological patients classified as ASA III, then retrospectively a review of their clinical history has been performed...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28982328/effect-of-oral-nonionic-polymeric-micelles-delivered-parathyroid-hormone-cdna-on-bone-density-and-microarchitecture
#7
Sung-Hsiung Chen, Jih-Yang Ko, Fong-Fu Chou
INTRODUCTION: Parathyroid hormone (PTH) is an effective therapeutic agent for osteoporosis, but the treatment requires long-term daily injections. Oral gene delivery is a less invasive alternative to daily injections. The aim of this study is to investigate the effect of orally administered nonionic polymeric micelles of plasmid cDNA containing human cytomegalovirus promoter (PCMV)-PTH (1-34) plus EDTA on body mineral density and bone microstructure in ovariectomized rats. A total of 27 Spraque-Dawley female rats were subjected to a bilateral ovariectomy...
October 4, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/28975570/ra-223-spect-for-semi-quantitative-analysis-in-comparison-with-tc-99m-hmdp-spect-phantom-study-and-initial-clinical-experience
#8
Yoshiki Owaki, Tadaki Nakahara, Takeo Kosaka, Junichi Fukada, Atsuhiro Kumabe, Akira Ichimura, Mikoto Murakami, Kiyotaka Nakajima, Masahiro Fukushi, Kazumasa Inoue, Mototsugu Oya, Masahiro Jinzaki
BACKGROUND: Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were to assess the feasibility and clinical usefulness of Ra-223 SPECT. The energy spectrum of Ra-223 and SPECT images of a cylindrical phantom with a hot rod were obtained to determine the collimator candidates and energy window settings suitable for clinical Ra-223 SPECT (basic study A)...
October 3, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28968061/comparative-in-vivo-investigation-of-intrathecal-and-intracerebroventricular-administration-with-melanocortin-ligands-mtii-and-agrp-into-mice
#9
Danielle N Adank, Mary M Lunzer, Cody J Lensing, Stacey L Wilber, Amy M Gancarz, Carrie Haskell-Luevano
Central administration of melanocortin ligands has been used as a critical technique to study energy homeostasis. While intracerebroventricular (ICV) injection is the most commonly used method during these investigations, intrathecal (IT) injection can be equally efficacious for the central delivery of ligands. Importantly, intrathecal administration can optimize exploration of melanocortin receptors in the spinal cord. Herein, we investigate comparative IT and ICV administration of two melanocortin ligands, the synthetic MTII (Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2) MC4R agonist and agouti-related peptide [AGRP(87-132)] MC4R inverse agonist/antagonist, on the same batch of age-matched mice in TSE metabolic cages undergoing a nocturnal satiated paradigm...
October 2, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28966827/spontaneous-pseudomeningocele-associated-with-lumbar-spondylolisthesis-a-case-report-and-review-of-the-literature
#10
Gonçalo Novais, Bernardo Ratilal, Lia Pappamikail, Pedro Branco, Nuno Reis
BACKGROUND: Pseudomeningocele, an extradural collection of cerebrospinal fluid (CSF), has only been rarely reported to occur spontaneously in conjunction with isthmic spondylolisthesis (with lysis) in the lumbar spine. CASE DESCRIPTION: A 68-year-old male presented with low back pain and neurogenic claudication of several years duration without any history of trauma, epidural spine injections, or spine surgery. Lumbosacral magnetic resonance imaging (MRI) revealed a grade-I L4-L5 isthmic spondylolisthesis with spinal canal narrowing and a posterior paravertebral collection consistent with CSF...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28962912/a-minimum-of-5-year-follow-up-after-lumbar-transforaminal-epidural-steroid-injections-in-patients-with-lumbar-radicular-pain-due-to-intervertebral-disc-herniation
#11
David J Kennedy, Patricia Z Zheng, Matthew Smuck, Zachary L McCormick, Lisa Huynh, Byron J Schneider
BACKGROUND CONTEXT: Patients with lumbosacral radiculopathy from a intervertebral disc herniation are frequently treated by transforaminal epidural steroid injections (TFESIs). The long-term outcomes of these patients are poorly described. PURPOSE: To determine the long-term outcomes for a homogenous group of patients with acute unilateral lumbar radicular pain due to single level herniated nucleus after lumbar epidural steroid injection at ≥5 years. DESIGN: Prospective cohort study...
September 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28962907/effect-of-pre-injection-opioid-use-on-post-injection-patient-reported-outcomes-following-epidural-steroid-injections-for-radicular-pain
#12
Johnny J Wei, Silky Chotai, Ahilan Sivaganesan, Kristin R Archer, Byron J Schneider, Aaron J Yang, Clinton J Devin
BACKGROUND CONTEXT: Chronic opioid therapy is associated with worse patient-reported outcomes (PROs) following spine surgery. However, little literature exists on the relationship between opioid use and patient-reported outcomes following epidural steroid injections for radicular pain. PURPOSE: We evaluated the association between pre-injection opioid use and patient-reported outcomes following spine epidural steroid injection. STUDY DESIGN: This study is a retrospective analysis of a prospective longitudinal registry database...
September 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28955005/accurate-diagnosis-of-chronic-low-back-pain-in-a-high-level-college-athlete-a-case-report
#13
Kenji Yokoyama, Kazuta Yamashita, Masatoshi Morimoto, Fumitake Tezuka, Fumio Hayashi, Yoichiro Takata, Toshinori Sakai, Kosaku Higashino, Takashi Chikawa, Hiroshi Yonezu, Akihiro Nagamachi, Koichi Sairyo
A 21-year-old woman who was high-level college softball player presented with a 6-month history of low back pain that had been treated unsuccessfully by medication at local clinics. There was tenderness in the left paravertebral muscle at the lower lumbar level. X-ray and computed tomography revealed congenital scoliosis and an L6 hemivertebra. Short tau inversion recovery magnetic resonance imaging showed a fluid collection at the left L6-S1 facet joint. We performed a diagnostic facet injection, consisting of 1% lidocaine and steroids, that was infiltrated into the left facet joint at L6-S1...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28952779/clinical-outcome-and-subsequent-sequelae-of-cement-extravasation-after-percutaneous-kyphoplasty-and-vertebroplasty-a-comparative-review
#14
Hassan Semaan, Tawfik Obri, Mohamad Bazerbashi, Daniel Paull, Xiaochen Liu, Marah Sarrouj, Hossein Elgafy
Background Injection of cement during vertebroplasty and kyphoplasty can leak into surrounding structures and could be symptomatic. Purpose To identify the sites and incidence of cement extravasation after kyphoplasty and vertebroplasty, and to evaluate their impacts on clinical outcomes. Material and Methods A retrospective review of 316 patients treated with kyphoplasty and vertebroplasty; 411 cases were included (223 kyphoplasty and 188 vertebroplasty). Cement extravasation was evaluated postoperatively by computed tomography (CT) scan of the spine...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28951964/ct-guided-minimally-invasive-treatment-for-an-extensive-spinal-epidural-abscess-a-case-report-and-literature-review
#15
Bing Ran, XinRong Chen, Qiong Zhong, Min Fu, Jun Wei
PURPOSE: We present a case involving an extensive epidural abscess that was successfully treated with computed tomography (CT)-guided percutaneous needle drainage and systemic antibiotic therapy. METHODS: A 44-year-old woman with a history of spine injection procedures complained of severe backache and progressive radiating pain in her right lower extremity followed by sensory deficits in her right lower limb. A laboratory examination revealed leukocytosis and hyperglycemia...
September 22, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28940863/a-phase-ii-study-of-radioimmunotherapy-with-intraventricular-131-i-3f8-for-medulloblastoma
#16
Kim Kramer, Neeta Pandit-Taskar, John L Humm, Pat B Zanzonico, Sofia Haque, Ira J Dunkel, Suzanne L Wolden, Maria Donzelli, Debra A Goldman, Jason S Lewis, Serge K Lyashchenko, Yasmin Khakoo, Jorge A Carrasquillo, Mark M Souweidane, Jeffrey P Greenfield, David Lyden, Kevin D De Braganca, Stephen W Gilheeney, Steven M Larson, Nai-Kong V Cheung
BACKGROUND: High-risk and recurrent medulloblastoma (MB) is associated with significant mortality. The murine monoclonal antibody 3F8 targets the cell-surface disialoganglioside GD2 on MB. We tested the efficacy, toxicity, and dosimetry of compartmental radioimmunotherapy (cRIT) with intraventricular (131) I-labeled 3F8 in patients with MB on a phase II clinical trial. METHODS: Patients with histopathologically confirmed high-risk or recurrent MB were eligible for cRIT...
September 22, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28940732/association-of-contextual-cues-with-morphine-reward-increases-neural-and-synaptic-plasticity-in-the-ventral-hippocampus-of-rats
#17
Mina Sadighi Alvandi, Maria Bourmpoula, Judith R Homberg, Yaghoub Fathollahi
Drug addiction is associated with aberrant memory and permanent functional changes in neural circuits. It is known that exposure to drugs like morphine is associated with positive emotional states and reward-related memory. However, the underlying mechanisms in terms of neural plasticity in the ventral hippocampus, a region involved in associative memory and emotional behaviors, are not fully understood. Therefore, we measured adult neurogenesis, dendritic spine density and brain-derived neurotrophic factor (BDNF) and TrkB mRNA expression as parameters for synaptic plasticity in the ventral hippocampus...
September 22, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28928494/systematic-review-and-meta-analyses-of-the-difference-between-the-spinal-level-of-the-palpated-and-imaged-iliac-crests
#18
Robert Cooperstein, Felisha Truong
OBJECTIVE: The purpose of this study was to undertake a systematic review of the literature to determine and compare, for patient sub-groups, the spinal level of the iliac crests as commonly measured through manual palpation and radiographic imaging procedures. METHODS: Relevant citations were retrieved by searching the PubMed, ICL, CINAHL, AMED, Osteopathic Research Web, OstMed, and MANTIS biomedical databases, and included articles were rated for quality. Search terms included Tuffier*, intercristal line, intercrestal line, Jacoby's line, lumbar spine, lumbar landmark, pelvic landmark, palpation, and TL (Tuffier's Line)...
August 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28927210/navigation-and-image-injection-for-control-of-bone-removal-and-osteotomy-planes-in-spine-surgery
#19
Michael Kosterhon, Angelika Gutenberg, Sven Rainer Kantelhardt, Elefterios Archavlis, Alf Giese
BACKGROUND AND IMPORTANCE: In contrast to cranial interventions, neuronavigation in spinal surgery is used in few applications, not tapping into its full technological potential. We have developed a method to preoperatively create virtual resection planes and volumes for spinal osteotomies and export 3-D operation plans to a navigation system controlling intraoperative visualization using a surgical microscope's head-up display. The method was developed using a Sawbone ® model of the lumbar spine, demonstrating feasibility with high precision...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28926652/particulate-or-nonparticulate-steroids-for-lumbar-transforaminal-injections
#20
Byron J Schneider, Zachary L McCormick, Clark C Smith
No abstract text is available yet for this article.
September 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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