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Chronic cerebral hypoperfusion

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https://www.readbyqxmd.com/read/28922154/atrial-fibrillation-is-independently-associated-with-cognitive-impairment-after-ischemic-stroke
#1
Russell Jude Chander, Levinia Lim, Sagarika Handa, Shaun Hiu, Angeline Choong, Xuling Lin, Rajinder Singh, Daniel Oh, Nagaendran Kandiah
BACKGROUND: While atrial fibrillation (AF) is an important risk factor for ischemic strokes and mild cognitive impairment (MCI) in Alzheimer's disease, the association between AF and post-stroke cognitive impairment (PSCI), and the factors mediating this association, is unclear. OBJECTIVE: To investigate the role of AF in PSCI, especially in relation to other markers of cerebrovascular disease. METHODS: 445 subjects with mild ischemic stroke without pre-stroke cognitive decline were assessed 3-6 months post-stroke for cognitive deficits...
September 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28920182/neovascularization-and-synaptic-function-regulation-with-memantine-and-rosuvastatin-in-a-rat-model-of-chronic-cerebral-hypoperfusion
#2
Nan Zhang, Chenchen Song, Baomin Zhao, Mengya Xing, Lanlan Luo, Marc L Gordon, Yan Cheng
Cerebral hypoperfusion is an important factor in the pathogenesis of cerebrovascular diseases and neurodegenerative disorders. We investigated the effects of memantine and rosuvastatin on both neovascularization and synaptic function in a rat model of chronic cerebral hypoperfusion, which was established by the bilateral common carotid occlusion (2VO) method. We tested learning and memory ability, synaptic function, circulating endothelial progenitor cell (EPC) number, expression of neurotrophic factors, and markers of neovasculogenesis and cell proliferation after memantine and/or rosuvastatin treatment...
September 17, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28855592/-s-oxiracetam-is-the-active-ingredient-in-oxiracetam-that-alleviates-the-cognitive-impairment-induced-by-chronic-cerebral-hypoperfusion-in-rats
#3
Wan Li, Huihui Liu, Hanjie Jiang, Chen Wang, Yongfei Guo, Yi Sun, Xin Zhao, Xin Xiong, Xianhua Zhang, Ke Zhang, Zongxiu Nie, Xiaoping Pu
Chronic cerebral hypoperfusion is a pathological state that is associated with the cognitive impairments in vascular dementia. Oxiracetam is a nootropic drug that is commonly used to treat cognitive deficits of cerebrovascular origins. However, oxiracetam is currently used as a racemic mixture whose effective ingredient has not been identified to date. In this study, we first identified that (S)-oxiracetam, but not (R)-oxiracetam, was the effective ingredient that alleviated the impairments of spatial learning and memory by ameliorating neuron damage and white matter lesions, increasing the cerebral blood flow, and inhibiting astrocyte activation in chronic cerebral hypoperfused rats...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842441/carotid-artery-stenosis-in-hypertensive-rats-impairs-dilatory-pathways-in-parenchymal-arterioles
#4
Nusrat Matin, Courtney Fisher, William F Jackson, Janice M Diaz-Otero, Anne M Dorrance
Hypertension is a leading risk factor for vascular cognitive impairment and is strongly associated with carotid artery stenosis. In normotensive rats, chronic cerebral hypoperfusion induced by bilateral common carotid artery stenosis (BCAS) leads to cognitive impairment that is associated with impaired endothelium-dependent dilation in parenchymal arterioles (PAs). The aim of this study was to assess the effects of BCAS on PA function and structure in stroke prone spontaneously hypertensive rats (SHRSP), a model of human essential hypertension...
August 25, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28840054/limb-remote-ischemic-conditioning-promotes-myelination-by-upregulating-pten-akt-mtor-signaling-activities-after-chronic-cerebral-hypoperfusion
#5
Xiaohua Li, Changhong Ren, Sijie Li, Rongrong Han, Jinhuan Gao, Qingjian Huang, Kunlin Jin, Yinghao Luo, Xunming Ji
Limb Remote ischemic conditioning (LRIC) has been proved to be a promising neuroprotective method in white matter lesions after ischemia; however, its mechanism underlying protection after chronic cerebral hypoperfusion remains largely unknown. Here, we investigated whether LRIC promoted myelin growth by activating PI3K/Akt/mTOR signal pathway in a rat chronic hypoperfusion model. Thirty adult male Sprague Dawley underwent permanent double carotid artery (2VO), and limb remote ischemic conditioning was applied for 3 days after the 2VO surgery...
July 2017: Aging and Disease
https://www.readbyqxmd.com/read/28836062/chronic-cerebral-hypoperfusion-promotes-amyloid-beta-pathogenesis-via-activating-%C3%AE-%C3%AE-secretases
#6
Zhiyou Cai, Zhou Liu, Ming Xiao, Chuanling Wang, Fuming Tian
Chronic cerebral hypoperfusion (CCH) contributes to the Alzheimer's-like pathogenesis, but the relationship between CCH and the occurrence of Alzheimer's disease (AD) remains obscure. The aim is to elucidate the potential pathophysiological mechanism in the field of amyloid-beta (Aβ) pathology induced by CCH. A rat model of CCH has been developed with permanent bilateral occlusion of common carotid arteries (BCCAO). The cognitive function of rats was tested by the Morris water maze. The levels of Aβ (Aβ40 and Aβ42) and soluble amyloid precursor protein (sAPP: sAPPα and sAPPβ) were determined by enzyme linked immunosorbent assay...
August 24, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28828966/chronic-cerebral-hypoperfusion-induced-by-bilateral-carotid-artery-stenosis-causes-selective-recognition-impairment-in-adult-mice
#7
Arati Patel, Alimohammad Moalem, Hank Cheng, Robin M Babadjouni, Kaleena Patel, Drew M Hodis, Deep Chandegara, Steven Cen, Shuhan He, Qinghai Liu, William J Mack
OBJECTIVES: Chronic cerebral hypoperfusion (CCH) can result in vascular dementia and small vessel white matter ischemic injury. These findings have previously been demonstrated in a murine experimental model of CCH secondary to bilateral common carotid artery stenosis (BCAS). This study sought to elucidate the effects of CCH on recognition memory as assessed by the novel object recognition (NOR) test and histological analysis of the hippocampus and perirhinal cortex. METHODS: Studies were performed on ten-week-old male mice using bilateral 0...
October 2017: Neurological Research
https://www.readbyqxmd.com/read/28798681/dl-3-n-butylphthalide-treatment-enhances-hemodynamics-and-ameliorates-memory-deficits-in-rats-with-chronic-cerebral-hypoperfusion
#8
Zhilin Xiong, Weibiao Lu, Lihui Zhu, Ling Zeng, Changzheng Shi, Zhen Jing, Yonghui Xiang, Wenxian Li, Chi Kwan Tsang, Yiwen Ruan, Li'an Huang
Our previous study has revealed that chronic cerebral hypoperfusion (CCH) activates a compensatory vascular mechanism attempting to maintain an optimal cerebral blood flow (CBF). However, this compensation fails to prevent neuronal death and cognitive impairment because neurons die prior to the restoration of normal CBF. Therefore, pharmacological invention may be critical to enhance the CBF for reducing neurodegeneration and memory deficit. Dl-3-n-butylphthalide (NBP) is a compound isolated from the seeds of Chinese celery and has been proven to be able to prevent neuronal loss, reduce inflammation and ameliorate memory deficits in acute ischemic animal models and stroke patients...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28798352/soluble-epoxide-hydrolase-inhibition-promotes-white-matter-integrity-and-long-term-functional-recovery-after-chronic-hypoperfusion-in-mice
#9
Yuxue Chen, Hao Tian, Ensheng Yao, Yeye Tian, Huaqiu Zhang, Li Xu, Zhiyuan Yu, Yongkang Fang, Wei Wang, Peng Du, Minjie Xie
Chronic cerebral hypoperfusion induced cerebrovascular white matter lesions (WMLs) are closely associated with cognitive impairment and other neurological deficits. The mechanism of demyelination in response to hypoperfusion has not yet been fully clarified. Soluble epoxide hydrolase (sEH) is an endogenous key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids. Inhibition of sEH has been suggested to represent a prototype "combination therapy" targeting multiple mechanisms of stroke injury with a single agent...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28766254/vegf-mediated-cognitive-and-synaptic-improvement-in-chronic-cerebral-hypoperfusion-rats-involves-autophagy-process
#10
Ling Wang, Jingyu Wang, Faqi Wang, Chunhua Liu, Xuening Yang, Jiajia Yang, Dong Ming
Chronic cerebral hypoperfusion (CCH) is associated with various neurodegenerative diseases characterized by cognitive impairment. Dozens of studies including ours have indicated that exogenous administration of vascular endothelial growth factor (VEGF) could exert effective cognitive protection during ischemia. Nevertheless, the underlying mechanism has not been well clarified. To address this issue, we explored the synaptic mechanisms in vivo since hippocampal synaptic function is essential to the learning and memory process...
August 1, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28722234/minocycline-reduces-microgliosis-and-improves-subcortical-white-matter-function-in-a-model-of-cerebral-vascular-disease
#11
Yasmina Manso, Philip R Holland, Akihiro Kitamura, Stefan Szymkowiak, Jessica Duncombe, Edel Hennessy, James L Searcy, Martina Marangoni, Andrew D Randall, Jon T Brown, Barry W McColl, Karen Horsburgh
Chronic cerebral hypoperfusion is a key mechanism associated with white matter disruption in cerebral vascular disease and dementia. In a mouse model relevant to studying cerebral vascular disease, we have previously shown that cerebral hypoperfusion disrupts axon-glial integrity and the distribution of key paranodal and internodal proteins in subcortical myelinated axons. This disruption of myelinated axons is accompanied by increased microglia and cognitive decline. The aim of the present study was to investigate whether hypoperfusion impairs the functional integrity of white matter, its relation with axon-glial integrity and microglial number, and whether by targeting microglia these effects can be improved...
July 19, 2017: Glia
https://www.readbyqxmd.com/read/28719802/cerebral-hypoperfusion-is-not-associated-with-an-increase-in-amyloid-%C3%AE-pathology-in-middle-aged-or-elderly-people
#12
Oskar Hansson, Sebastian Palmqvist, Hanna Ljung, Tobias Cronberg, Danielle van Westen, Ruben Smith
INTRODUCTION: It is hypothesized that cerebral hypoperfusion promotes the development of Alzheimer pathology. We therefore studied whether longstanding cerebral hypoperfusion is associated with Alzheimer pathology in nondemented humans. METHODS: Cerebral blood flow and amyloid β ((18)F-Flutemetamol) positron emission tomography retention were assessed in eleven patients with unilateral occlusion of precerebral arteries resulting in chronic and uneven hypoperfusion...
July 15, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28667120/chronic-cerebral-hypoperfusion-alters-amyloid-%C3%AE-peptide-pools-leading-to-cerebral-amyloid-angiopathy-microinfarcts-and-haemorrhages-in-tg-swdi-mice
#13
Natalia Salvadores, James L Searcy, Philip R Holland, Karen Horsburgh
Cerebral hypoperfusion is an early feature of Alzheimer's disease (AD) that influences the progression from mild cognitive impairment to dementia. Understanding the mechanism is of critical importance in the search for new effective therapies. We hypothesized that cerebral hypoperfusion promotes the accumulation of amyloid-β (Aβ) and degenerative changes in the brain and is a potential mechanism contributing to development of dementia. To address this, we studied the effects of chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis on Aβ peptide pools in a transgenic mouse model of AD (transgenic mice with Swedish, Dutch and Iowa mutations in human amyloid precursor protein (APP) (Tg-SwDI))...
August 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28655874/long-term-cilostazol-treatment-reduces-gliovascular-damage-and-memory-impairment-in-a-mouse-model-of-chronic-cerebral-hypoperfusion
#14
Akihiro Kitamura, Yasmina Manso, Jessica Duncombe, James Searcy, Juraj Koudelka, Margaret Binnie, Scott Webster, Ross Lennen, Maurits Jansen, Ian Marshall, Masafumi Ihara, Raj N Kalaria, Karen Horsburgh
Chronic cerebral hypoperfusion is a major cause of age-related vascular cognitive impairment. A well-characterised mouse model has shown that hypoperfusion results in gliovascular and white matter damage and impaired spatial working memory. In this study, we assessed whether cilostazol, a phosphodiesterase III inhibitor, could protect against these changes. Adult, male C57Bl/6J mice were subjected to bilateral common carotid artery stenosis or a sham operation and fed normal or cilostazol diet for three months...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28638040/-complex-application-2-ethyl-6-methyl-3-hydroxypyridine-succinate-and-vinpocetine-in-cerebrovascular-disorder
#15
E Yu Solovyeva, A N Karneev, A V Chekanov, O A Baranova, I V Choi
Developing brain ischemia due to cerebral vascularization leads to disruption of brain metabolism. Chronic cerebral hypoperfusion leads to irreversible brain damage and plays an important role in the development of some types of dementia. Early use of antioxidants such as ethyl ether apovincamine acid (vinpocetine) and 2-ethyl-6-methyl-3-hydroxypyridine-succinate in the treatment of this pathology is seen as a real pathogenetically based method of correction of cerebral metabolism with cerebral vascular disorders, demonstrating the increase in cerebral blood flow and also neuroprotective effects...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28634859/erratum-to-erythropoietin-rescues-memory-impairment-in-a-rat-model-of-chronic-cerebral-hypoperfusion-via-the-epo-r-jak2-stat5-pi3k-akt-gsk-3%C3%AE-pathway
#16
Shengli Ma, Juwu Chen, Chen Chen, Na Wei, Jingjing Xu, Guohui Yang, Nan Wang, Yu Meng, Jia Ren, Zongchao Xu
No abstract text is available yet for this article.
June 20, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28632329/postictal-hypoperfusion-hypoxia-provides-the-foundation-for-a-unified-theory-of-seizure-induced-brain-abnormalities-and-behavioral-dysfunction
#17
REVIEW
Jordan S Farrell, Roberto Colangeli, Marshal D Wolff, Alexandra K Wall, Thomas J Phillips, Antis George, Paolo Federico, G Campbell Teskey
A recent article by Farrell et al. characterizes the phenomenon, mechanisms, and treatment of a local and severe hypoperfusion/hypoxia event that occurs in brain regions following a focal seizure. Given the well-established role of cerebral ischemia/hypoxia in brain damage and behavioral dysfunction in other clinical settings (e.g., stroke, cerebral vasospasm), we put forward a new theory: postictal hypoperfusion/hypoxia is responsible for the negative consequences associated with seizures. Fortunately, inhibition of two separate molecular targets, cyclooxygenase-2 (COX-2) and l-type calcium channels, can prevent the expression of postictal hypoperfusion/hypoxia...
September 2017: Epilepsia
https://www.readbyqxmd.com/read/28620701/chronic-cerebral-hypoperfusion-induced-synaptic-proteome-changes-in-the-rat-cerebral-cortex
#18
Katalin Völgyi, Péter Gulyássy, Mihail Ivilinov Todorov, Gina Puska, Kata Badics, Dávid Hlatky, Katalin Adrienna Kékesi, Gabriella Nyitrai, András Czurkó, László Drahos, Arpád Dobolyi
Chronic cerebral hypoperfusion (CCH) evokes mild cognitive impairment (MCI) and contributes to the progression of vascular dementia and Alzheimer's disease (AD). How CCH induces these neurodegenerative processes that may spread along the synaptic network and whether they are detectable at the synaptic proteome level of the cerebral cortex remains to be established. In the present study, we report the synaptic protein changes in the cerebral cortex after stepwise bilateral common carotid artery occlusion (BCCAO) induced CCH in the rat...
June 15, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28615922/influence-of-circulating-endothelin-1-and-asymmetric-dimethylarginine-on-whole-brain-circulation-time-in-multiple-sclerosis
#19
Lucia Monti, Lucia Morbidelli, Lorenzo Bazzani, Alessandro Rossi
Blood-brain barrier (BBB) breakdown, inflammatory and immune cell activation, and chronic cerebral hypoperfusion are features of multiple sclerosis (MS). The aim is to determine the influence of endothelin-1 (ET1) and asymmetric dimethylarginine (ADMA) on cerebral circulation time (CCT) in patients with MS. In all, 64 patients with MS (39 relapsing-remitting [RR]-MS; 25 secondary progressive [SP]-MS subtype) and 37 controls (C) were studied. Cerebral circulation time was obtained by angiography. Plasmatic ET1 and ADMA were measured by enzyme-linked immunosorbent assay...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28606482/the-neuron-astrocyte-microglia-triad-in-ca3-after-chronic-cerebral-hypoperfusion-in-the-rat-protective-effect-of-dipyridamole
#20
Daniele Lana, Filippo Ugolini, Alessia Melani, Daniele Nosi, Felicita Pedata, Maria Grazia Giovannini
We investigated the quantitative and morphofunctional alterations of neuron-astrocyte-microglia triads in CA3 hippocampus, in comparison to CA1, after 2 Vessel Occlusion (2VO) and the protective effect of dipyridamole. We evaluated 3 experimental groups: sham-operated rats (sham, n=15), 2VO-operated rats treated with vehicle (2VO-vehicle, n=15), and 2VO-operated rats treated with dipyridamole from day 0 to day 7 (2VO-dipyridamole, n=15), 90days after 2VO. We analyzed Stratum Pyramidalis (SP), Stratum Lucidum (SL) and Stratum Radiatum (SR) of CA3...
June 9, 2017: Experimental Gerontology
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