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https://www.readbyqxmd.com/read/28099948/mdm4-genetic-variants-and-risk-of-gastric-cancer-in-an-eastern-chinese-population
#1
Meng-Yun Wang, Ming Jia, Jing He, Fei Zhou, Li-Xin Qiu, Meng-Hong Sun, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Ya-Nong Wang, Qing-Yi Wei
MDM4 is a p53-interacting protein and plays an important role in carcinogenesis. In this study of 1,077 gastric cancer (GCa) cases and 1,173 matched cancer-free controls, we investigated associations between three tagging single nucleotide polymorphisms (SNPs) (rs11801299 G>A, rs1380576 C>G and rs10900598 G>T) in MDM4 and gastric cancer risk in an Eastern Chinese Population. In logistic regression analysis, a significantly decreased GCa risk was associated with the rs1380576 GG variant genotype (adjusted odds ratio [OR] =0...
January 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28079831/gastric-cancer-burden-of-last-40-years-in-north-china-hebei-province-a-population-based-study
#2
Di Liang, Suoyuan Liang, Jing Jin, Daojuan Li, Jin Shi, Yutong He
Gastric cancer (GC) is the second leading cause of cancer death in China. It is well known that Cixian in Hebei Province is one of the highest risk areas of GC in China and worldwide. This study aims to accurate assessment of GC burden and trend in high-risk area (Hebei Province) from 1973 to 2013. The authors analyzed GC data from 21 population-based cancer registries which represented 15.25% of the entire population of Hebei Province. The collected data were stratified by 5-year age groups, gender, and area...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079232/predictive-features-for-histology-of-gastric-subepithelial-lesions
#3
Ricardo Teles Schulz, Lizandra Castilho Fabio, Matheus Cavalcante Franco, Sheila A Siqueira, Paulo Sakai, Fauze Maluf-Filho
BACKGROUND: - Gastric subepithelial lesion is a relatively common diagnosis after routine upper endoscopy. The diagnostic workup of an undetermined gastric subepithelial lesion should take into consideration clinical and endoscopic features. OBJECTIVE: - We aimed to investigate the association between patients' characteristics, endoscopic and echographic features with the histologic diagnosis of the gastric subepithelial lesions. METHODS: - This is a retrospective study with 55 patients, who were consecutively diagnosed with gastric subepithelial lesions, from October 2008 to August 2011...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28067081/-relationship-of-consequences-of-anastomotic-insufficiency-and-bacterial-flora-of-oral-cavity-in-patients-with-esophageal-and-cardia-cancer
#4
Ákos Balázs, Beáta Winkler, Katalin Kristóf, László Harsányi, Lívia Bokor
INTRODUCTION: In the course of anastomotic insufficiency following resection of esophageal cancers the bacterial compound of the esophageal substance has a remarkable, presumable role in the outcome of complications. AIM: The purpose of this study is to compare the consequences of the anastomotic leak with the bacterial flora of patients' oral cavity. METHOD: In this prospective study a total of 131 patients were investigated directly before the surgical intervention taking a bacterial sample...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28040054/histological-and-histochemical-characterization-of-the-digestive-tract-of-european-catfish-silurus-glanis-linnaeus-1758
#5
S Köprücü, M Yaman
In this study was to examined the morphology, histology and histochemically the digestive tract of European catfish, Silurus glanis. Two-four age S. glanis obtained from Çelik Lake (Gölbaşı-Adıyaman, Turkey). Six S. glanis, 59-71 cm length, 1.5-3.2 kg weight used for in the investigation. The body cavity was opened and samples of digestive tract (esophagus, stomach and intestine) were fixed in neutral buffered 10% formalin and embedded in paraffin. Dewaxed section (5-6 µm) were deparaffinized and stained with haematoxylin and eosin (H&E), Crossman triple, periodic acid-shiff (PAS), alcian blue (AB, pH 1...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28036293/a-retrospective-study-of-nens-and-mir-224-promotes-apoptosis-of-bon-1-cells-by-targeting-pcsk9-inhibition
#6
Jian'an Bai, He Na, Xiumei Hua, Yaling Wei, Tian Ye, Yiqiang Zhang, Guo Jian, Weiwen Zeng, Lijun Yan, Qiyun Tang
Neuroendocrine neoplasms (NENs) represent relatively rare tumors. The lack of diagnostic, therapeutic method and prognostic factors makes them a challenge to us. We retrospectively reviewed the data of 205 NENs patients among which 157 cases were followed-up. Proprotein convertase subtilisin/kexin 9 (PCSK9), a regulator of low density lipoprotein cholesterol (LDL-C), was confirmed as a target gene of microRNA-224. We found an increased incidence of NENs from 2012 to 2015. Women were usually diagnosed at earlier stages than men (P < 0...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28031722/low-plce1-levels-are-correlated-with-poor-prognosis-in-hepatocellular-carcinoma
#7
Ya Cheng, Song-Ge Xing, Wei-Dong Jia, Mei Huang, Na-Na Bian
BACKGROUND: Previous reports show that phospholipase C epsilon-1 (PLCE1) expression is positively correlated with esophageal squamous cell carcinoma and gastric cardia adenocarcinomas; however, the expression of PLCE1 in hepatocellular carcinoma (HCC) and its correlation with clinical outcome still remain unclear. The aim of this study was to explore the expression of PLCE1 in HCC tissue and to determine whether PLCE1 was a prognostic factor for HCC patients. MATERIALS AND METHODS: PLCE1 levels in 20 paired HCC tissues and corresponding paracarcinomatous tissues was investigated by quantitative real-time polymerase chain reaction and Western blot assays...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28028499/barrett-s-mucosa-segmentation-in-endoscopic-images-using-a-hybrid-method-spatial-fuzzy-c-mean-and-level-set
#8
Hossein Yousefi-Banaem, Hossein Rabbani, Peyman Adibi
Barrett's mucosa is one of the most important diseases in upper gastrointestinal system that caused by gastro-esophagus reflux. If left untreated, the disease will cause distal esophagus and gastric cardia adenocarcinoma. The malignancy risk is very high in short segment Barrett's mucosa. Therefore, lesion area segmentation can improve specialist decision for treatment. In this paper, we proposed a combined fuzzy method with active models for Barrett's mucosa segmentation. In this study, we applied three methods for special area segmentation and determination...
October 2016: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/28018426/combination-of-five-body-positions-can-effectively-improve-the-rate-of-gastric-mucosa-s-complete-visualization-by-applying-magnetic-guided-capsule-endoscopy
#9
Yuting Qian, Sheng Wu, Qi Wang, Lumin Wei, Wei Wu, Lifu Wang, Ye Chu
Objectives. Achieving a comprehensive view of gastric mucosa has been a challenge for magnetic-guided capsule endoscopy (MGCE) for years. This study works on optimizing the performance of MGCE by changing the conventional positions to the five body positions. Methods. Sixty patients were enrolled in the study and underwent MGCE. All patients were asked to adopt five body positions (left lateral, supine, right lateral, knee-chest, and sitting). In each position, the ability to visualize the six gastric landmarks (cardia, fundus, body, angulus, antrum, and pylorus) was assessed...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28018111/clinical-features-of-upper-gastrointestinal-serrated-lesions-an-endoscopy-database-analysis-of-98746-patients
#10
Hai-Long Cao, Wen-Xiao Dong, Meng-Que Xu, Yu-Jie Zhang, Si-Nan Wang, Mei-Yu Piao, Xiao-Cang Cao, Bang-Mao Wang
AIM: To analyse the clinical features of patients with the serrated lesions in the upper gastrointestinal tract (UPGI) tract. METHODS: Patients who underwent routine esophagogastroduodenoscopy (EGD) at the Digestive Endoscopy Centre of General Hospital, Tianjin Medical University between January 2011 and December 2015 were consecutively recruited. Patients with UPGI serrated lesions were consecutively identified. The patients' demographics and histopathology were recorded...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28002320/ca125-is-a-potential-biomarker-to-predict-surgically-incurable-gastric-and-cardia-cancer-a-retrospective-study
#11
Taobo Luo, Wenhu Chen, Lifang Wang, Hongguang Zhao
Preoperative evaluation of the curability of gastric and cardia cancer is important to avoid risks of unnecessary surgery. Our previous study has reported several clinical parameters associated with incurable gastric surgery. In this study, we aimed to evaluate the correlation between CA125 and the curability of gastric and cardia cancer.A total of 297 cases of gastric and cardia cancer were analyzed retrospectively, including 153 cases with radical surgery and 144 with surgery for incurable gastric or cardia cancer...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27986126/aberrant-cpg-island-shore-region-methylation-of-cav1-is-associated-with-tumor-progression-and-poor-prognosis-in-gastric-cardia-adenocarcinoma
#12
Yan-Li Guo, Tie-Nian Zhu, Wei Guo, Zhi-Ming Dong, Zhen Zhou, Yu-Jie Cui, Rui-Jing Zhao
BACKGROUND AND AIMS: Caveolin-1 (CAV1) is a multifunctional scaffolding protein and plays an important role in tumorigenesis. However, the epigenetic changes of CAV1 in gastric cardia adenocarcinoma (GCA) have not been investigated so far. The purpose of this study was to clarify the contribution of critical CpG sites in CAV1 to progression/prognosis of GCA and to further elucidate the effect of critical CpG sites on the ectopic expression of β-catenin in GCA. METHODS: Methylation-specific polymerase chain reaction (MSP) and bisulfite genomic sequencing (BGS) methods were, respectively, applied to examine the methylation status of CAV1...
August 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27977508/open-versus-hand-assisted-laparoscopic-total-gastric-resection-with-d2-lymph-node-dissection-for-adenocarcinoma-a-case-control-study
#13
Guang-Tan Zhang, Xue-Dong Zhang, Huan-Zhou Xue
OBJECTIVE: A case-control study was conducted to investigate the feasibility and safety of hand-assisted laparoscopic total gastrectomy (HALTG) with D2 lymphadenectomy for gastric cancer as opposed to traditional open total gastrectomy (OTG). METHODS: One hundred fifty-four patients suffering cardia, upper, middle, or whole gastric cancer operated in our department from February 2009 to February 2012 were divided into 2 groups: the open total gastrectomy group (the OTG group) and the hand-assisted laparoscopic total gastrectomy group (the HALTG group)...
December 13, 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27976795/first-in-human-experience-with-the-cardia-ultraseal-left-atrial-appendage-closure-device-the-feasibility-study
#14
Robert Sabiniewicz, Jarosław Hiczkiewicz, Piotr Wańczura, Wojciech Stecko, Andrzej Curzytek
No abstract text is available yet for this article.
2016: Cardiology Journal
https://www.readbyqxmd.com/read/27966210/ghrelin-immunoreactive-cells-in-the-gastrointestinal-tract-of-hypertensive-rats
#15
Izabela Janiuk, Jerzy Kaleczyc, Irena Kasacka
INTRODUCTION: Ghrelin, an appetite-stimulating hormone secreted by the endocrine cells of the gastrointestinal (GI) tract, has recently been shown to affect the function of the cardiovascular system. This study aimed to assess the number and morphology of ghrelin-immunopositive (GhrIP) cells in the gastrointestinal tract of rats at different developmental phases of experimentally evoked renovascular hypertension. MATERIAL AND METHODS: The study involved 40 rats divided into two groups: control (C; n = 20) and rats with experimentally induced hypertension (EH; n = 20)...
2016: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/27955962/pneumatic-dilation-for-functional-helix-stenosis-after-sleeve-gastrectomy-long-term-follow-up-with-videos
#16
Gianfranco Donatelli, Jean-Loup Dumont, Guillame Pourcher, Hadrien Tranchart, Thierry Tuszynski, Ibrahim Dagher, Jean-Marc Catheline, Renaud Chiche, Jean-Pierre Marmuse, Stavros Dritsas, Bertrand-Marie Vergeau, Bruno Meduri
BACKGROUND: A large number of patients who undergo laparoscopic sleeve gastrectomy present with surgical complications. Stenosis, in particular, occurs in .7%-4% of cases. OBJECTIVES: To report our experience, results, and long-term follow-up after pneumatic dilation of late functional helix stenosis after laparoscopic sleeve gastrectomy. SETTING: Multicenter study led by an endoscopic tertiary referral center. METHODS: Thirty-five patients were dilated initially at 30 mm...
September 28, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27935662/antibacterial-activity-of-glass-ionomer-cement-modified-by-zinc-oxide-nanoparticles
#17
Patrícia Petromilli Nordi Sasso Garcia, Mariana Florian Bell Cardia, Renata Serignoli Francisconi, Lívia Nordi Dovigo, Denise Madalena Palomari Spolidório, Alessandra Nara de Souza Rastelli, Ana Carolina Botta
This study evaluated the antibacterial activity of zinc oxide nanoparticles incorporated into self-cured glass ionomer cement (GIC) and light-cured resin-reinforced GIC on Streptococcus mutans biofilm. The GICs, Fuji II (GC America) and Fuji II LC (GC America), were incorporated with nanoparticles at concentrations of 0%, 1%, and 2% by weight, and the biofilm maturation time was one and seven days. Circular specimens of each GIC type were prepared. The antibacterial activity was evaluated by determining the number of colony forming units of S...
December 9, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27929458/in-vivo-biosensor-tracks-non-apoptotic-caspase-activity-in-drosophila
#18
Ho Lam Tang, Ho Man Tang, Ming Chiu Fung, J Marie Hardwick
Caspases are the key mediators of apoptotic cell death via their proteolytic activity. When caspases are activated in cells to levels detectable by available technologies, apoptosis is generally assumed to occur shortly thereafter. Caspases can cleave many functional and structural components to cause rapid and complete cell destruction within a few minutes. However, accumulating evidence indicates that in normal healthy cells the same caspases have other functions, presumably at lower enzymatic levels. Studies of non-apoptotic caspase activity have been hampered by difficulties with detecting low levels of caspase activity and with tracking ultimate cell fate in vivo...
November 27, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27928793/-subtype-classification-and-clinicopathological-characteristics-of-gastric-neuroendocrine-neoplasms-an-analysis-of-241-cases
#19
Pan Zhang, Yu Zhang, Chi Zhang, Yanfen Shi, Jixi Liu, Qing Liu, Lili Yu, Miao Wang, Guoming Zou, Jie Lou, Jie Chen, Huangying Tan
OBJECTIVE: To study subtype classification of gastric neuroendocrine neoplasm (NEN) and their clinicopathological characteristics in order to provide reference for clinical practice. METHODS: Clinicopathological data of 241 gastric NEN patients (174 cases from China-Japan Friendship Hospital and 67 cases from The First Affiliated Hospital of Sun Yat-Sen University) between January 2011 and June 2016 were retrospectively summarized. According to serum gastrin, 24-hour intragastric pH monitoring and pathological grade, patients with gastric NEN were divided into 4 types: type I( (hypergastrinemia and achlorhydria, related to autoimmune chronic atrophic gastritis), type II( [hypergastrinemia and Zollinger-Ellison syndrome, related to gastrinoma or multiple endocrine neoplasia type I( (MEN-I()], type III( (sporadic disease with normal serum gastrin level), and type IIII( [poorly differentiated gastric neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma (MANEC)]...
November 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27909899/obesity-and-risk-of-cancer-an-introductory-overview
#20
Tobias Pischon, Katharina Nimptsch
The prevalence of obesity has increased substantially in the past in almost all countries of the world, and a further increase is expected for the future. Besides the well-established effects on type 2 diabetes and cardiovascular disease, there is convincing evidence today that obesity also increases the risk of several types of cancer, including colorectal cancer, postmenopausal breast cancer, endometrial cancer, renal cell carcinoma, esophageal adenocarcinoma, pancreatic cancer, and liver cancer. Obesity probably also increases the risk of ovarian cancer, advanced prostate cancer, gallbladder cancer, and gastric cardia cancer...
2016: Recent Results in Cancer Research
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