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CARDIA study

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https://www.readbyqxmd.com/read/28930282/esophageal-cancer-genomic-and-molecular-characterization-stem-cell-compartment-and-clonal-evolution
#1
REVIEW
Ugo Testa, Germana Castelli, Elvira Pelosi
Esophageal cancer (EC) is the eighth most common cancer and is the sixth leading cause of death worldwide. The incidence of histologic subtypes of EC, esophageal adenocarcinoma (EAC) and esophageal squamous carcinoma (ESCC), display considerable geographic variation. EAC arises from metaplastic Barrett's esophagus (BE) in the context of chronic inflammation secondary to exposure to acid and bile. The main risk factors for developing ESCC are cigarette smoking and alcohol consumption. The main somatic genetic abnormalities showed a different genetic landscape in EAC compared to ESCC...
September 14, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929584/association-between-oral-leukoplakia-and-risk-of-upper-gastrointestinal-cancer-death-a-follow-up-study-of-the-linxian-general-population-trial
#2
He Liang, Zhao Yang, Jian-Bing Wang, Pei Yu, Jin-Hu Fan, You-Lin Qiao, Philip R Taylor
BACKGROUND: This study was conducted to explore the association between oral leukoplakia (OL) and the risk of upper gastrointestinal cancer death in the Linxian General Population Trial Cohort. METHODS: A prospective cohort study of the Linxian General Population Trial Cohort was performed. Participants with OL were treated as an exposed group, and the remainder was selected as a control group. All subjects were followed monthly by village health workers and reviewed quarterly by the Linxian Cancer Registry...
September 20, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28927559/association-of-aortic-root-dilation-from-early-adulthood-to-middle-age-with-cardiac-structure-and-function-the-cardia-study
#3
Chike C Nwabuo, Henrique T Moreira, Henrique D Vasconcellos, Bharath Ambale-Venkatesh, Kihei Yoneyama, Yoshiaki Ohyama, Ravi K Sharma, Anderson C Armstrong, Mohammed R Ostovaneh, Cora E Lewis, Kiang Liu, Pamela J Schreiner, Kofo O Ogunyankin, Samuel S Gidding, João A C Lima
BACKGROUND: The human aorta dilates with advancing age. However, the association between progressive aortic dilation with aging and cardiac remodeling has not been established in studies of community-dwelling adults. The aim of this study was to test the hypothesis that there would be a relationship between aortic size increase over the early adult life span with left ventricular (LV) structural remodeling and subclinical LV dysfunction in middle age, even in the absence of overt cardiovascular and valvular disease...
September 15, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28924092/extralobar-pulmonary-sequestration-in-two-pinniped-species
#4
Shotaro Nakagun, Hirotaka Watanabe, Kenji Ochiai, Kaoru Kohyama, Wataru Goshima, Yoko Goto, Yumi Kobayashi, Kennichi Watanabe, Noriyuki Horiuchi, Jun Sasaki, Masanobu Goryo, Yoshiyasu Kobayashi
Two cases of extralobar pulmonary sequestrations from a walrus (Odobenus rosmarus) and a Steller sea lion (Eumetopias jubatus) are described in the present study. Grossly, an independent, soft unilocular cystic mass was found within the abdominal cavities of both animals, adherent to the diaphragm in O. rosmarus and attached to the cardia of the stomach in E. jubatus. Histopathologically, the cysts were lined by pseudostratified ciliated columnar epithelium with abundant goblet cells, while the wall comprised of glands, hyaline cartilage, bronchiole- and alveolus-like structures, smooth muscles, and large, well-developed elastic and muscular arteries...
September 17, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28900994/-analysis-of-gastric-gastrointestinal-stromal-tumors-in-shandong-province-a-midterm-report-of-multicenter-gissg1201-study
#5
Qingsheng Hou, Wenqiang Luo, Leping Li, Yong Dai, Lixin Jiang, Ailiang Wang, Xianqun Chu, Yuming Li, Daogui Yang, Chunlei Lu, Linguo Yao, Gang Cui, Huizhong Lin, Gang Chen, Qing Cui, Huanhu Zhang, Zengjun Lun, Lijian Xia, Yingfeng Su, Guoxin Han, Xizeng Hui, Zhixin Wei, Zuocheng Sun, Hongliang Guo, Yanbing Zhou
OBJECTIVE: To summarize the treatment status of gastric gastrointestinal stromal tumor (GIST) in Shandong province,by analyzing the clinicopathological features and prognostic factors. METHODS: Clinicopathological and follow-up data of 1 165 patients with gastric GIST between January 2000 and December 2013 from 23 tertiary referral hospitals in Shandong Province were collected to establish a database. The risk stratification of all cases was performed according to the National Institutes of Health(NIH) criteria proposed in 2008...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28888185/helicobacter-pylori-serological-biomarkers-of-gastric-cancer-risk-in-the-mcc-spain-case-control-study
#6
Nerea Fernández de Larrea-Baz, Beatriz Pérez-Gómez, Angelika Michel, Beatriz Romero, Virginia Lope, Michael Pawlita, Tania Fernández-Villa, Victor Moreno, Vicente Martín, Martina Willhauck-Fleckenstein, Gonzalo López-Abente, Jesús Castilla, Guillermo Fernández-Tardón, Trinidad Dierssen-Sotos, Miguel Santibáñez, Rosana Peiró, José Juan Jiménez-Moleón, Carmen Navarro, Gemma Castaño-Vinyals, Manolis Kogevinas, Marina Pollán, Silvia de Sanjosé, Rosa Del Campo, Tim Waterboer, Nuria Aragonés
BACKGROUND: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. METHODS: Incident gastric cancer cases and population controls (age, sex and region frequency-matched) from the MCC-Spain multicase-control Study were included. Seroreactivities against 16H. pylori proteins were determined using multiplex serology...
September 6, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28885685/gut-microbiota-derived-endotoxin-enhanced-the-incidence-of-cardia-bifida-during-cardiogenesis
#7
Jing Zhang, Guang Wang, Jia Liu, Lin-Rui Gao, Meng Liu, Chao-Jie Wang, Manli Chuai, Yongping Bao, Ge Li, Rui-Man Li, Yu Zhang, Xuesong Yang
Background Cytotoxicity and inflammation-associated toxic responses could be induced by bacterial lipopolysaccharides (LPS) in vitro and in vivo respectively. However, the mechanism involved in LPS-induced cardiac malformation in prenatal fetus is still unknown. Methods and results In this study, we demonstrated that LPS was induced in gut microbiota imbalance mice, and next, LPS exposure during gastrulation in the chick embryo increased the incidence of cardia bifida. Gene transfection and tissue transplantation trajectory indicated that LPS exposure restricted the cell migration of cardiac progenitors to primary heart field in gastrula chick embryos...
September 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28859394/esophageal-achalasia-a-risk-factor-for-carcinoma-a-systematic-review-and-meta-analysis
#8
F Tustumi, W M Bernardo, J R M da Rocha, S Szachnowicz, F C Seguro, E T Bianchi, R A A Sallum, I Cecconello
Achalasia of the cardia is associated with an increased risk of esophageal carcinoma. The real burden of achalasia at the malignancy genesis is still a controversial issue. Therefore, there are no generally accepted recommendations on follow-up evaluation for achalasia patients. This study aims to estimate the risk of esophageal adenocarcinoma and squamous cell carcinoma in achalasia patients. We searched for association between carcinoma and esophageal achalasia in databases up to January 2017 to perform a systematic review and meta-analysis...
October 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28846807/two-penetrating-vessels%C3%A2-as-a-novel-indicator-of-the-appropriate-distal-end-of-per-oral-endoscopic-myotomy
#9
Shinwa Tanaka, Fumiaki Kawara, Takashi Toyonaga, Haruhiro Inoue, Robert Bechara, Namiko Hoshi, Hirohumi Abe, Yoshiko Ohara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki
OBJECTIVES: One of the challenges during per-oral endoscopic myotomy (POEM) is ensuring the appropriate length of myotomy on the gastric side. To determine the appropriate distal end of the gastric myotomy, we focused on the two penetrating vessels (TPVs) found in the gastric cardia during POEM. In this study, we evaluated whether the TPVs could serve as an accurate indicator of the appropriate distal end of the gastric myotomy. METHODS: All patients who underwent POEM between March and August 2016 were included for this study...
August 28, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28840505/anesthesia-in-per-oral-endoscopic-myotomy-a-large-tertiary-care-centre-experience
#10
Santosh Darisetty, Zaheer Nabi, Mohan Ramchandani, Radhika Chavan, Rama Kotla, D Nageshwar Reddy
BACKGROUND AND OBJECTIVES: Per-oral endoscopic myotomy (POEM) is safe and efficacious for the management of achalasia cardia (AC). POEM is usually performed under general anesthesia in an endoscopy suite or operating theatre. The current study was conducted with the aim to analyse anesthetic management of patients with AC who underwent POEM at our institution. METHODS: We retrospectively analysed the data of patients with AC who underwent POEM at our institution from January 2013 to September 2016...
August 24, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28838990/marijuana-use-and-estimated-glomerular-filtration-rate-in-young-adults
#11
Julie H Ishida, Reto Auer, Eric Vittinghoff, Mark J Pletcher, Jared P Reis, Stephen Sidney, Kirsten L Johansen, Kirsten Bibbins-Domingo, Carmen A Peralta, Michael G Shlipak
BACKGROUND AND OBJECTIVES: Marijuana use has become more widely accepted in the United States and has been legalized in many areas. Although it is biologically plausible that marijuana could affect kidney function, epidemiologic data are lacking. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a cohort study among young adults with preserved eGFR (i.e., eGFR≥60 ml/min per 1.73 m(2)) using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study...
August 24, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28838062/the-validity-of-predictive-equations-to-estimate-24-hour-sodium-excretion-the-mesa-and-cardia-urinary-sodium-study
#12
Norrina B Allen, Lihui Zhao, Catherine M Loria, Linda Van Horn, Chia-Yih Wang, Christine M Pfeiffer, Mary E Cogswell, Jacqueline Wright, Kiang Liu
We examined the population distribution of urinary sodium concentrations and the validity of existing equations predicting 24-hour sodium excretion from a single spot urine sample among older adults with and without hypertension. In 2013, 24-hour urine collections were obtained from 554 participants in the Multi-Ethnic Study of Atherosclerosis and the Coronary Artery Risk Development in Young Adults study, who were aged 45-79 years and of whom 56% were female, 58% were African American, and 54% had hypertension, in Chicago, Illinois...
July 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28831737/adjuvant-chemoradiotherapy-for-non-pretreated-gastric-cancer
#13
V K Y Ho, E P M Jansen, B P L Wijnhoven, K J Neelis, J W van Sandick, R H A Verhoeven, V E P Lemmens, H W M van Laarhoven
BACKGROUND: While the curative approach to gastric cancer includes perioperative regimens in several countries, a substantial proportion of patients may not receive treatment prior to surgery. This study examines the adjuvant provision of chemoradiotherapy (CRT) for non-pretreated patients with cancer of the stomach including the gastric cardia. METHODS: All surgically treated patients with primary adenocarcinoma of the stomach and gastric cardia diagnosed between January 2004-December 2013 were selected from the Netherlands Cancer Registry...
August 22, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28819392/long-term-trends-in-primary-sites-of-gastric-adenocarcinoma-in-japan-and-the-united-states
#14
Michitaka Honda, Sandra L Wong, Mark A Healy, Toshifusa Nakajima, Masayuki Watanabe, Shingo Fukuma, Shunichi Fukuhara, John Z Ayanian
Background: The incidence and characteristics of gastric cancer have been shown to vary widely across Western and Eastern countries. Our study had two aims: to evaluate long-term trends in gastric adenocarcinoma in Japan over a period of 70 years, and to anticipate the future of gastric cancer in Japan, through comparison with data from the United States. Methods: Japanese patient data for 19,306 incident cases of gastric adenocarcinoma from 1946 - 2014 were collected from the Gastric Cancer Database at the Cancer Institute Hospital, Tokyo, Japan (CIH-GCDB)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28804625/the-relationship-between-tumor-necrosis-factor-%C3%AE-polymorphisms-and-gastric-cancer-risk-an-updated-meta-analysis
#15
Wenxian Zheng, Shuisheng Zhang, Shenfeng Zhang, Li Min, Yihong Wang, Jian Xie, Yong Hou, Xiufang Tian, Jian Cheng, Kun Liu, Deguo Xu, Xinshuang Yu, Zhen Liu, Yajuan Lv, Ning Liang, Jiandong Zhang, Fengjun Liu, Yuan Tian
The aim of the present study was to evaluate the relationship between tumor necrosis factor-α (TNF-α) and the development of gastric cancer, and to investigate whether it can be used as a biological marker for gastric cancer. In the current study, a new meta-analysis was performed to assess the association between TNF-α gene polymorphisms and gastric cancer susceptibility. Subgroup analyses based on ethnicity, control population source and non-cardia cancers were also conducted. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28791679/effect-of-age-on-rates-of-palliative-surgery-and-chemotherapy-use-in-patients-with-locally-advanced-or-metastatic-gastric-cancer
#16
S D Nelen, M van Putten, V E P P Lemmens, K Bosscha, J H W de Wilt, R H A Verhoeven
BACKGROUND: This study assessed trends in the treatment and survival of palliatively treated patients with gastric cancer, with a focus on age-related differences. METHODS: For this retrospective, population-based, nationwide cohort study, all patients diagnosed between 1989 and 2013 with non-cardia gastric cancer with metastasized disease or invasion into adjacent structures were selected from the Netherlands Cancer Registry. Trends in treatment and 2-year overall survival were analysed and compared between younger (age less than 70 years) and older (aged 70 years or more) patients...
August 9, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28768652/nut-and-peanut-butter-consumption-and-the-risk-of-esophageal-and-gastric-cancer-subtypes
#17
Maryam Hashemian, Gwen Murphy, Arash Etemadi, Sanford M Dawsey, Linda M Liao, Christian C Abnet
Background: Nut consumption has been associated with decreased risk of colorectal, endometrial, lung, and pancreatic cancers. Polyphenols, fiber, vitamins, and minerals in nuts may confer this observed protective effect. To our knowledge, no prospective study has evaluated the effect of nut consumption on esophageal and gastric cancers.Objective: The objective was to evaluate the associations between nut and peanut butter consumption and the risk of esophageal and gastric cancers and their different subtypes...
September 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28768650/intake-of-niacin-folate-vitamin-b-6-and-vitamin-b-12-through-young-adulthood-and-cognitive-function-in-midlife-the-coronary-artery-risk-development-in-young-adults-cardia-study
#18
Bo Qin, Pengcheng Xun, David R Jacobs, Na Zhu, Martha L Daviglus, Jared P Reis, Lyn M Steffen, Linda Van Horn, Stephen Sidney, Ka He
Background: Epidemiologic evidence regarding niacin, folate, vitamin B-6, and vitamin B-12 intake in relation to cognitive function is limited, especially in midlife.Objective: We hypothesize that higher intake of these B vitamins in young adulthood is associated with better cognition later in life.Design: This study comprised a community-based multicenter cohort of black and white men and women aged 18-30 y in 1985-1986 (year 0, i.e., baseline) from the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3136)...
August 2, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28763913/-analysis-of-psychological-status-and-relevant-factors-of-patients-with-esophageal-and-gastric-cardia-precancerous-lesions-in-linzhou-of-henan
#19
S R Ma, Q Ma, C Q Hao, C T Guan, B Y Li, J W Wang, X Q Li, Z K Liu, W W Wei
Objective: To explore the psychological status and related factors in patients with precancerous of esophageal and gastric cardia in Linzhou of Henan. Methods: Clinical psycho-rating scale of Social Support Rating Scale (SSRS), Self-Rating Anxiety Scale (SAS, score ≥50 points with symptoms of anxiety) and Self-Rating Depression Scale (SDS, score ≥53 points with the symptoms of depression) were applied to survey life events and psychological status of subjects who aged 40-69 years old and participated in"The Early diagnosis and Early Treatment"program in Linzhou cancer hospital from July 2015 to Jan 2016...
August 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28753933/deciphering-molecular-mechanisms-of-interface-buildup-and-stability-in-porous-si-eumelanin-hybrids
#20
Elisa Pinna, Claudio Melis, Aleandro Antidormi, Roberto Cardia, Elisa Sechi, Giancarlo Cappellini, Marco d'Ischia, Luciano Colombo, Guido Mula
Porous Si/eumelanin hybrids are a novel class of organic-inorganic hybrid materials that hold considerable promise for photovoltaic applications. Current progress toward device setup is, however, hindered by photocurrent stability issues, which require a detailed understanding of the mechanisms underlying the buildup and consolidation of the eumelanin-silicon interface. Herein we report an integrated experimental and computational study aimed at probing interface stability via surface modification and eumelanin manipulation, and at modeling the organic-inorganic interface via formation of a 5,6-dihydroxyindole (DHI) tetramer and its adhesion to silicon...
July 19, 2017: International Journal of Molecular Sciences
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