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CARDIA study

Liangli Hong, Ying Zhang, Zhaoyong Liu
Neuroendocrine carcinoma (NEC) of the esophagus and gastric cardia is a rare tumor, and the Chaoshan region has one of the highest incidences of esophageal and gastric cardia cancer (GCC) worldwide. The aim of this study was to characterize the clinicopathologic features of esophageal NEC ( n = 67) and gastric cardia NEC ( n = 13) cases identified over a 9-year period in the Chaoshan region. Esophageal NECs were either purely NEC ( n = 47) or mixed with squamous cell carcinoma or adenocarcinoma ( n = 20). For GCC; pure NEC was found in 5 cases, whereas 8 cases were mixed with adenocarcinomas...
February 13, 2018: Oncotarget
Dongfang Li, Daojuan Li, Guohui Song, Di Liang, Chao Chen, Yachen Zhang, Zhaoyu Gao, Yutong He
Cixian is one of the high-risk areas for upper gastrointestinal cancer in China and the world. From 2005, comprehensive population-based screening for upper gastrointestinal cancers has been conducted in Cixian. The aim of this study was to investigate population-based cancer survival from 2003 to 2013 and to explore the effect of screening on upper gastrointestinal cancer survival in Cixian. Observed survival was estimated using the life table method. The expected survival from the general population was calculated using all-cause mortality data from the population of Cixian with the EdererII method...
March 13, 2018: Cancer Medicine
Ignacio Cruz-Gonzalez, Monica Fuertes-Barahona, Jose C Moreno-Samos, Rocio Gonzalez-Ferreiro, Yan Yin Lam, Pedro L Sanchez
Since the first percutaneous left atrial appendage occlusion (LAAO), many studies have shown the safety and efficacy of this technique to prevent embolic strokes in nonvavular atrial fibrillation. The design, characteristics, and clinical data of the most frequently used devices for LAAO are reviewed, including the Amplatzer cardiac plug and Amulet (Abbott Vascular), the Watchman (Boston Scientific), and the LARIAT device (SentreHEART). Similarly, newer closer devices, such as Ultraseal (Cardia), LAmbre (Lifetech), and Coherex WaveCrest (Johnson & Johnson), are also discussed...
April 2018: Interventional Cardiology Clinics
Kara M Whitaker, Katherine H Ingram, Duke Appiah, Wanda K Nicholson, Wendy L Bennett, Cora E Lewis, Jared P Reis, Pamela J Schreiner, Erica P Gunderson
PURPOSE: To assess the associations of pre-pregnancy cardiorespiratory fitness, moderate-to vigorous-intensity physical activity (MVPA), and time spent watching television with subsequent development of gestational diabetes mellitus (GDM). METHODS: Participants were 1,333 women enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study who did not have diabetes either at baseline (1985-86) or prior to births occurring after baseline. Baseline fitness was estimated using a graded symptom-limited maximal exercise treadmill test and expressed in metabolic equivalent (MET) units...
March 8, 2018: Medicine and Science in Sports and Exercise
A C Valezi, J Mali, M A Menezes, R O Sato
BACKGROUND: Many surgeons prefer a narrow gastrojejunostomy in gastric bypass believing that this provides greater weight loss. The question is whether the anastomosis remains at its initial diameter, whether it narrows or widens over time. This study tests the hypothesis that the initial diameter of the anastomosis varies over time. MATERIALS AND METHODS: One hundred obese had undergone surgery. Group A with anastomosis 1.5 cm wide and group B with anastomosis 3 cm wide...
March 7, 2018: Obesity Surgery
Elaine Ku, Eric Vittinghoff, David R Jacobs, Cora E Lewis, Norrina B Allen, Kirsten Bibbins-Domingo, Michael Shlipak, Holly Kramer, Carmen A Peralta
BACKGROUND: Many studies have focused on the association between a single blood pressure (BP) measurement and risk for adverse outcomes. However, the association of BP trajectories during young adulthood with subsequent decline in kidney function has not been well defined. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: 3,429 participants in the Coronary Artery Risk Development in Young Adulthood (CARDIA) Study enrolled between the ages of 18 and 30 years...
March 3, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Y H M Claassen, H H Hartgrink, J L Dikken, W O de Steur, J W van Sandick, N C T van Grieken, A Cats, A K Trip, E P M Jansen, W M Meershoek-Klein Kranenbarg, J P B M Braak, H Putter, M I van Berge Henegouwen, M Verheij, C J H van de Velde
BACKGROUND: In order to determine the optimal combination of perioperative chemotherapy and chemoradiotherapy for Western patients with advanced resectable gastric cancer, the international multicentre CRITICS trial (ChemoRadiotherapy after Induction chemotherapy In Cancer of the Stomach) was initiated. In this trial, patients with resectable gastric cancer were randomised before start of treatment between adjuvant chemotherapy or adjuvant chemoradiotherapy following neoadjuvant chemotherapy plus gastric cancer resection...
February 9, 2018: European Journal of Surgical Oncology
Ming-Yan Cai, Bo-Qun Zhu, Mei-Dong Xu, Wen-Zheng Qin, Yi-Qun Zhang, Wei-Feng Chen, Marie Ooi, Quan-Lin Li, Li-Qing Yao, Ping-Hong Zhou
BACKGROUND AND AIM: The management of subepithelial tumors with a predominant extraluminal growth pattern or extra-gastrointestinal (GI) tumors can be challenging and traditionally requires a surgical resection that is not only invasive but may carry a significant risk of morbidity and mortality. We aim to assess the feasibility, safety and efficacy of a novel endoscopic technique termed as submucosal tunnel endoscopic resection for Extraluminal Tumors (STER-ET). METHODS: We prospectively enrolled patients who underwent STER-ET for gastrointestinal subepithelial tumors with a predominant extraluminal growth pattern or extra-GI tumors located at the level of cardia or the proximal part of the lesser curvature of the stomach seen on cross-sectional imaging between January 2016 and March 2017...
February 27, 2018: Gastrointestinal Endoscopy
Fenglin Liu, Xinyu Qin
Many retrospective and cohort studies have shown that laparoscopic total gastrectomy(LTG) has advantages of less trauma, quicker recovery and better incision than open total gastrectomy, and is not inferior to laparotomy in safety and the short- and long-term outcomes, so it has been widely applied. However there is still a lack of high level evidence-based basis. At present, several prospective multicenter clinical studies are being carried out in China, Japan and South Korea which have high incidence of gastric cancer to demonstrate the safety and feasibility of LTG and evaluate its long-term outcomes as well...
February 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Roberto Mijangos-Vázquez, Antonio J García-Montes, Elena M Soto-López, Verónica Guarner-Lans, Carlos Zabal
OBJECTIVES: The objective of this study was to demonstrate the safety and feasibility of using the new Cardia Ultrasept II™ device with interposed Goretex patch referring to the perforation of polyvinyl alcohol membrane. BACKGROUND: Great advances have been made in the development of devices for closure of atrial septal defect. The Cardia Ultrasept II™ with interposed Goretex patch is the modified last generation of Cardia devices, having the advantage of a super-low profile within the atria and an integral locking delivery-retrieval mechanism that ensures safe deployment...
February 27, 2018: Cardiology in the Young
Minkyo Song, M Constanza Camargo, Stephanie J Weinstein, Ana F Best, Satu Männistö, Demetrius Albanes, Charles S Rabkin
BACKGROUND: Family history may inform risks of gastric cancer and preneoplastic lesions. METHODS: We examined associations with history of cancer in first-degree relatives for 307 incident gastric cancer cases among 20,720 male smokers in a prospective study in Finland. Cox regression was used to calculate gastric cancer hazard ratios (HR) and 95% confidence intervals (95% CI). Logistic regression was used to estimate odds ratios (OR) and 95% CIs for low serum pepsinogen, a marker of gastric atrophy...
February 17, 2018: Gastric Cancer
D Martín-Vega, A Garbout, F Ahmed, L M Ferrer, J Lucientes, D D Colwell, M J R Hall
Oestrid flies (Diptera: Oestridae) do not feed during the adult stage as they acquire all necessary nutrients during the parasitic larval stage. The adult mouthparts and digestive tract are therefore frequently vestigial; however, morphological data on the alimentary canal in adult oestrid flies are scarce and a proper visualization of this organ system within the adult body is lacking. The present work visualizes the morphology of the alimentary canal in adults of two oestrid species, Oestrus ovis L. and Hypoderma lineatum (de Villiers), with the use of non-invasive micro-computed tomography (micro-CT) and compares it with the highly developed alimentary canal of the blow fly Calliphora vicina Robineau-Desvoidy (Diptera: Calliphoridae)...
February 16, 2018: Medical and Veterinary Entomology
Zaheer Nabi, Mohan Ramchandani, Radhika Chavan, Rakesh Kalapala, Santosh Darisetty, D Nageshwar Reddy
Background and Aim: Peroral endoscopic myotomy (POEM) is a technically demanding procedure. Recently, a new triangular knife with integrated water jet function (TTJ) has been introduced. The present study was aimed to analyze and compare the operating time, efficacy, and adverse events (AEs) between the conventional (TT knife) and new knife (TTJ). Patients and Methods: All patients with achalasia cardia (AC) who underwent POEM between August 2015 and November 2016 were analyzed retrospectively...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Abbi D Lane-Cordova, Erica P Gunderson, Mercedes R Carnethon, Janet M Catov, Alex P Reiner, Cora E Lewis, Annie M Dude, Philip Greenland, David R Jacobs
Endothelial dysfunction is a form of subclinical cardiovascular disease that may be involved in preterm birth and small-for-gestational-age deliveries. However, concentrations of biomarkers of endothelial dysfunction before pregnancy have rarely been measured. We hypothesized that higher levels of biomarkers of endothelial dysfunction (cellular adhesion molecules and selectins) would be associated with odds of preterm birth and/or small-for-gestational-age deliveries. We included 235 women from the Coronary Artery Risk Development in Young Adults (CARDIA) study who were nulliparous at Y7, reported ≥1 live birth through Y25, and had ≥1 biomarker measured at Y7...
February 15, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Marwan Saad, Naga Venkata Pothineni, Joseph Thomas, Richa Parikh, Swathi Kovelamudi, Dina Elsayed, Ramez Nairooz, Frederick Feit
PURPOSE OF REVIEW: This review aims to summarize the evidence and challenges of coronary artery calcium (CAC) scoring as a screening tool for coronary artery disease (CAD) in young adults. RECENT FINDINGS: Several cohort studies have highlighted the value of CAC scoring in CAD risk assessment in young adults. The largest study to date is the Coronary Artery Risk Development in Young Adults (CARDIA) study. The study examined patients at 18-30 years of age and demonstrated that the presence of any degree of CAC was associated with a higher risk of coronary events compared to zero CAC, with an incremental increase in the risk of events with higher scores...
February 12, 2018: Current Cardiology Reports
Nima Tabatabaei, DongKyun Kang, Minkyu Kim, Tao Wu, Catriona N Grant, Mireille Rosenberg, Norman S Nishioka, Paul E Hesterberg, John Garber, Qian Yuan, Aubrey J Katz, Guillermo J Tearney
Esophagogastroduodenoscopy (EGD) is a widely used procedure, posing significant financial burden on both healthcare systems and patients. Moreover, EGD is time consuming, sometimes difficult to tolerate, and suffers from an imperfect diagnostic yield as the limited number of collected biopsies does not represent the whole organ. In this paper, we report on technological and clinical feasibility of a swallowable tethered endomicroscopy capsule, which is administered without sedation, to image large regions of esophageal and gastric mucosa at the cellular level...
February 8, 2018: Scientific Reports
Ying Li, Yu Ye, Yang Mei, Haiying Ruan, Yuan Yu
BACKGROUND AND OBJECTIVE: At present, the enteral nutrition approaches via nose and duodenum (or nose and jejunum) are the preferred method of nutritional support in the medical engineering field, given the superiority of in line with physiological processes and no serious complication. In this study, the authors adopted saline as the acoustic window, and gave enteral nutrition support to critically ill patients, via the nasogastrojejunal approach guided by semi-automated ultrasound. These above patients benefited a lot from this kind of nutrition support treatment, and we aimed to report the detailed information...
February 7, 2018: Biomedical Engineering Online
Mohan Ramchandani, Zaheer Nabi, D Nageshwar Reddy, Rahul Talele, Santosh Darisetty, Rama Kotla, Radhika Chavan, Manu Tandan
Background and study aims:  Peroral endoscopic myotomy (POEM) can be performed via an anterior or posterior approach, depending on the operator's preference. Data are lacking on comparative outcomes of both approaches. Patients and methods:  This is a pilot randomized study comparing endoscopic anterior and posterior myotomy during POEM in patients with Achalasia cardia (AC). Patients were randomized into 2 groups (n = 30 in each group); anterior myotomy group (AG) and posterior myotomy group (PG) and were followed at 1, 3 and 6 months after POEM...
February 2018: Endoscopy International Open
Naruhiko Ikoma, Janice N Cormier, Barry Feig, Xianglin L Du, Jose-Miguel Yamal, Wayne Hofstetter, Prajnan Das, Jaffer A Ajani, Christina L Roland, Keith Fournier, Richard Royal, Paul Mansfield, Brian D Badgwell
BACKGROUND: No studies have investigated whether race/ethnicity is associated with the recommended use of preoperative chemotherapy or subsequent outcomes in gastric cancer. To determine whether there is such an association, analyses of patients with gastric cancer in the National Cancer Data Base (NCDB) were performed. METHODS: Patients with clinical T2-4bN0-1M0 gastric adenocarcinoma, as defined by the eighth edition of the American Joint Committee on Cancer staging manual, who underwent gastrectomy from 2006 to 2014 were identified from the NCDB...
February 2, 2018: Cancer
Ying Meng, Jiazhao Zhang, Huijun Wang, Yiping Zhang, Ruirui Sun, Zhen Zhang, Fang Gao, Chengsuo Huang, Shu Zhang
RATIONALE: Primary squamous cell carcinoma (SCC) of the stomach is a rare disease. The pathogenesis and prognosis of advanced SCC remains to be elucidated. The aim of the current study was to investigate the prognosis of recurrent or metastatic SCC of the stomach. PATIENT CONCERNS: A retrospective study examined the clinical characteristics and survival outcomes of 14 patients diagnosed with recurrent or metastatic SCC of the stomach, including 7 patients followed up in the hospital and 7 patients selected from the PubMed and Chinese National Knowledge Infrastructure (CNKI) database with meta-analysis between January 2003 and January 2016...
December 2017: Medicine (Baltimore)
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