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CARDIA study

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https://www.readbyqxmd.com/read/29140553/outcomes-of-pneumatic-dilation-in-achalasia-extended-follow-up-of-more-than-25-years-with-a-focus-on-manometric-subtypes
#1
Michaela Müller, Christina Keck, Alexander J Eckardt, Sarah Werling, Till Wehrmann, Jochem König, Ines Gockel
BACKGROUND AND AIMS: Pneumatic dilation (PD) is the most popular non-surgical treatment for achalasia. This study investigated predicting factors, including manometric subtypes for symptom recurrence in the long-term, in patients with achalasia treated with a single PD. PATIENTS AND METHODS: Between 1983 and 2013, a total of 107 patients were treated initially with a single PD and included in this longitudinal cohort study. Outcomes were correlated with demographics, symptoms (Eckardt Score), esophagographic and manometric features...
November 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29139048/high-adherence-to-the-western-prudent-and-mediterranean-dietary-patterns-and-risk-of-gastric-adenocarcinoma-mcc-spain-study
#2
Adela Castelló, Nerea Fernández de Larrea, Vicente Martín, Verónica Dávila-Batista, Elena Boldo, Marcela Guevara, Víctor Moreno, Gemma Castaño-Vinyals, Inés Gómez-Acebo, Guillermo Fernández-Tardón, Rosana Peiró, Rocío Olmedo-Requena, Rocio Capelo, Carmen Navarro, Silvino Pacho-Valbuena, Beatriz Pérez-Gómez, Manolis Kogevinas, Marina Pollán, Nuria Aragonés
BACKGROUND: The influence of dietary habits on the development of gastric adenocarcinoma is not clear. The objective of the present study was to explore the association of three previously identified dietary patterns with gastric adenocarcinoma by sex, age, cancer site, and morphology. METHODS: MCC-Spain is a multicase-control study that included 295 incident cases of gastric adenocarcinoma and 3040 controls. The association of the Western, Prudent, and Mediterranean dietary patterns-derived in another Spanish case-control study-with gastric adenocarcinoma was assessed using multivariable logistic regression models with random province-specific intercepts and considering a possible interaction with sex and age...
November 14, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29134503/short-and-long-term-outcomes-of-endoscope-assisted-laparoscopic-wedge-resection-for-gastric-submucosal-tumors-adjacent-to-esophagogastric-junction
#3
Xin Ye, Jianchun Yu, Weiming Kang, Zhiqiang Ma, Zhigang Xue
BACKGROUND: Laparoscopic wedge resection (LWR) is used to treat gastric submucosal tumors (SMTs). However, LWR can injure the cardia if tumors are near the esophagogastric junction (EGJ), resulting in gastric stenosis. This study's purpose was to summarize our experience with endoscope-assisted LWR for gastric SMTs within 3 cm of the EGJ and to verify the procedure's feasibility and safety. METHODS: Data from 91 consecutive patients with gastric SMTs within 3 cm of the EGJ who underwent endoscope-assisted LWR at our hospital from 2007 to 2017 were obtained from a prospectively maintained database...
November 13, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29128412/association-between-gestational-diabetes-and-incident-maternal-ckd-the-coronary-artery-risk-development-in-young-adults-cardia-study
#4
Elizabeth W Dehmer, Milind A Phadnis, Erica P Gunderson, Cora E Lewis, Kirsten Bibbins-Domingo, Stephanie M Engel, Michele Jonsson Funk, Holly Kramer, Abhijit V Kshirsagar, Gerardo Heiss
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with increased risk for diabetes mellitus, metabolic syndrome, and cardiovascular disease. We evaluated whether GDM is associated with incident chronic kidney disease (CKD), controlling for prepregnancy risk factors for both conditions. STUDY DESIGN: Prospective cohort. SETTING & PARTICIPANTS: Of 2,747 women (aged 18-30 years) enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) Study in 1985 to 86, we studied 820 who were nulliparous at enrollment, delivered at least 1 pregnancy longer than 20 weeks' gestation, and had kidney function measurements during 25 years of follow-up...
November 8, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29127726/self-reported-marijuana-use-over-25-years-and-abdominal-adiposity-the-coronary-artery-risk-development-in-young-adults-cardia-study
#5
Michael P Bancks, Reto Auer, J Jeffrey Carr, David C Goff, Catarina Kiefe, Jamal S Rana, Jared Reis, Stephen Sidney, James G Terry, Pamela J Schreiner
AIMS: We investigated the association between cumulative lifetime and current marijuana use with total abdominal adipose tissue (AT), visceral AT, subcutaneous AT, intermuscular AT, and mean liver attenuation (LA) at mid-life. DESIGN: Longitudinal and cross-sectional secondary data analysis of participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. SETTING: CARDIA field centers in Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA, USA...
November 11, 2017: Addiction
https://www.readbyqxmd.com/read/29116623/kras-mutation-in-gastric-cancer-and-prognostication-associated-with-microsatellite-instability-status
#6
Karol Polom, Kakoli Das, Daniele Marrelli, Giandomenico Roviello, Valeria Pascale, Costantino Voglino, Henry Rho, Patrick Tan, Franco Roviello
Microsatellite instability (MSI) is one of the subgroups based on the new molecular classification of gastric cancer (GC). In this study, we analyzed the role of KRAS status in MSI GC and the impact of MSI status on KRAS mutation. We performed analysis on 595 GC patients. Polymerase chain reaction (PCR) was used for the screening of KRAS mutation (exon 2) and 5 quasi-monomorphic mononucleotide repeats, namely, BAT-26, BAT-25, NR -24, NR-21, and NR-27 were used to determine the MSI status. The KRAS and MSI status were then compared with clinicopathologic data of the GC patients...
November 8, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29114921/association-of-early-left-ventricular-dysfunction-with-advanced-magnetic-resonance-white-matter-and-gray-matter-brain-measures-the-cardia-study
#7
Anderson C Armstrong, Majon Muller, Bharath Ambale-Ventakesh, Michael Halstead, Satoru Kishi, Nick Bryan, Stephen Sidney, Luís C L Correia, Samuel S Gidding, Lenore J Launer, João A C Lima
INTRODUCTION: Relations between heart failure and clinically manifested stroke are well known, but the associations between heart and brain early abnormalities are not totally clear. AIMS: We explore relations of subclinical brain abnormalities with early cardiac dysfunction in a large healthy middle-aged biracial cohort. METHODS: The CARDIA study enrolled 5115 young adults aged 18-30 years at baseline (1985-1986). We assessed 719 Caucasian and African American participants of the CARDIA study, with echocardiograms and brain MRI at follow-up year 25 (2010-2011)...
November 8, 2017: Echocardiography
https://www.readbyqxmd.com/read/29108336/prognostic-factors-influencing-the-survival-of-patients-with-carcinoma-of-the-gastric-cardia-receiving-preoperative-interventional-embolization-chemotherapy
#8
Hai-Li Cao, Shu-Qiang Jin, Kai-Bing Wang, Bin Bai
The purpose of this study was to analyze the characteristics of patients with gastric cardia cancer (GCC) to identify the main factors the influence the survival rate after interventional embolization chemotherapy (IEC). One hundred and fifty-six patients with advanced GCC were treated with IEC via the left gastric artery. Survival time was defined as from the date of diagnosis until death or the end of this study in June 2015. The median survival time was 15 months (range 3 to 29 months). The Cox proportional hazard model found that patients' age (p < 0...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29101561/non-exposure-simple-suturing-endoscopic-full-thickness-resection-ness-eftr-versus-laparoscopic-wedge-resection-a-randomized-controlled-trial-in-a-porcine-model
#9
Hong Man Yoon, Chan Gyoo Kim, Jong Yeul Lee, Soo-Jeong Cho, Myeong-Cherl Kook, Bang Wool Eom, Keun Won Ryu, Young-Woo Kim, Il Ju Choi
BACKGROUND: Current endoscopic full-thickness resection (EFTR) methods produce transmural communication and expose the tumor to the peritoneum. An EFTR method with a simple suturing technique that does not expose the gastric mucosa to the peritoneum (non-exposure simple suturing, NESS) was recently developed. To date, there have been no prospective studies that compare EFTR with laparoscopic wedge resection in human or animal. The aim of this study was to compare outcomes between NESS-EFTR and laparoscopic wedge resection (LWR) using the linear staplers in a randomized animal study...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29089698/laparoscopic-heller-s-myotomy-for-achalasia-cardia-one-time-treatment-in-developing-countries
#10
Vishal Gupta, Hunaid Hatimi, Saket Kumar, Abhijit Chandra
Laparoscopic Heller's myotomy (LHM) and endoscopic balloon dilation are two main treatment modalities for achalasia cardia. The best treatment modality in Indian setting, however, is still unknown. Here, we present the early results of LHM in achalasia. Hospital data from January 2009 to October 2013 was analyzed. Preoperative assessment included Eckardt's scoring, esophagogastroduodenoscopy, barium swallow examination, and esophageal manometry. Thirty-five patients (19 males and 16 females, median age 31 years, range 12-65) underwent LHM with partial fundoplication (with intraoperative endoscopy)...
October 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29080827/clinical-importance-of-non-participation-in-a-maximal-graded-exercise-test-on-risk-of-non-fatal-and-fatal-cardiovascular-events-and-all-cause-mortality-cardia-study
#11
Kelley Pettee Gabriel, Kara M Whitaker, Daniel Duprez, Barbara Sternfeld, Cora E Lewis, Steve Sidney, Gregory Knell, David R Jacobs
While poor performance during a maximal graded exercise test (GXT) predicts cardiovascular events and premature mortality, the potential clinical importance of non-participation in a GXT, either for medical or non-medical reasons, is currently unknown. Data are from 4086 and 3547 Coronary Artery Risk Development in Young Adults (CARDIA) participants who attended the Year 7 (ages 25-37years) and/or 20 exams (ages 38-50years), respectively, which included a GXT. Cox proportional hazard models were used to examine the effect of GXT disposition (at Year 7 and 20, separately) on risk of non-fatal and fatal cardiovascular events and all-cause mortality obtained through 28years of follow-up...
October 25, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29075555/sex-hormones-and-brain-volumes-in-a-longitudinal-study-of-middle-aged-men-in-the-cardia-study
#12
Martine Elbejjani, Pamela J Schreiner, David S Siscovick, Stephen Sidney, Cora E Lewis, Nick R Bryan, Lenore J Launer
INTRODUCTION: Several findings suggest that testosterone (T) is neuroprotective and that declining T levels during aging are associated with cognitive and brain pathologies; however, little is known on T and brain health in middle-age. We examined the relationships of total T, bioavailable T, and sex hormone binding globulin (SHBG) levels with total and regional gray matter (GM) and white matter (WM) volumes in middle-aged men. We also evaluated the association of sex hormone levels with cognitive function...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29071073/rapid-decline-in-lung-function-in-healthy-adults-predicts-incident-excess-urinary-albumin-excretion-later-in-life
#13
Sapna Bhatia, Clifford Qualls, Thomas A Crowell, Alexander Arynchyn, Bharat Thyagarajan, Lewis J Smith, Ravi Kalhan, David R Jacobs, Holly Kramer, Daniel Duprez, Bartolome Celli, Akshay Sood
INTRODUCTION: Chronic lung disease, often characterised by rapid decline in lung function, is associated with vascular endothelial dysfunction (characterised by moderate to severe excess urinary albumin excretion (eUAE) but their longitudinal relationship is inadequately studied. In a bidirectional longitudinal examination of healthy adults, we analysed the following two hypotheses: (1) rapid decline (ie, highest tertile of lung function decline) predicts eUAE and (2) eUAE predicts rapid decline...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29069739/a-nation-wide-retrospective-epidemiological-study-of-gastroenteropancreatic-neuroendocrine-neoplasms-in-china
#14
Jin-Hu Fan, Yu-Qing Zhang, Su-Sheng Shi, Yuan-Jia Chen, Xing-Hua Yuan, Li-Ming Jiang, Shao-Ming Wang, Li Ma, Yu-Tong He, Chang-Yan Feng, Xi-Bin Sun, Qing Liu, Katrina Deloso, Yihebali Chi, You-Lin Qiao
BACKGROUND: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients. METHODS: This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients' information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29063494/bariatric-embolization-of-the-left-gastric-arteries-for-the-treatment-of-obesity-9-month-data-in-5-patients
#15
Zhi-Bin Bai, Yong-Lin Qin, Gang Deng, Guo-Feng Zhao, Bin-Yan Zhong, Gao-Jun Teng
PURPOSE: The purpose of this study is to investigate the safety and 9-month effectiveness of transcatheter left gastric artery embolization (LGAE) for treating patients with obesity. MATERIALS AND METHODS: The protocol of this study was approved by the Institutional Ethics Review Board. Five obese patients (3 men and 2 women) with mean weight of 102.0 ± 16.19 kg (range, 82.1-125.5 kg) and mean body mass index (BMI) of 38.1 kg/m(2) ± 3.8 (range, 32.9-42...
October 23, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29063447/stage-iv-gastric-cancer-successfully-treated-by-multidisciplinary-therapy-including-chemotherapy-immunotherapy-and-surgery-a-case-report
#16
Makoto Kawamoto, Hideya Onishi, Norihiro Koya, Hiroyuki Konomi, Kenji Mitsugi, Risa Tanaka, Junichi Motoshita, Takashi Morisaki, Masafumi Nakamura
BACKGROUND: The prognosis of stage IV gastric cancer (GC) still remains unfavorable. Multidisciplinary approaches should therefore be considered to improve the survival of patients with stage IV GC. We report here a case of primary GC with potentially unresectable metastasis, successfully treated by a multidisciplinary approach including chemotherapy, immunotherapy, and surgery. CASE PRESENTATION: A 74-year-old man presented with multiple left neck masses. Abdominal computed tomography showed a thickened gastric wall and multiple lymphadenopathies including left supraclavicular lymph node...
October 23, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29056683/dissecting-the-role-of-the-extracellular-matrix-in-heart-disease-lessons-from-the-drosophila-genetic-model
#17
REVIEW
Chris J R Hughes, J Roger Jacobs
The extracellular matrix (ECM) is a dynamic scaffold within organs and tissues that enables cell morphogenesis and provides structural support. Changes in the composition and organisation of the cardiac ECM are required for normal development. Congenital and age-related cardiac diseases can arise from mis-regulation of structural ECM proteins (Collagen, Laminin) or their receptors (Integrin). Key regulators of ECM turnover include matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of matrix metalloproteinases (TIMPs)...
April 24, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29053810/associations-between-cellular-aging-markers-and-metabolic-syndrome-findings-from-the-cardia-study
#18
Dóra Révész, Josine E Verhoeven, Martin Picard, Jue Lin, Stephen Sidney, Elissa S Epel, Brenda W J H Penninx, Eli Puterman
Background: Metabolic syndrome (MetS) is thought to promote biological aging, which might lead to cardiovascular and aging-related complications. This large-scale study investigated longitudinal relationships between MetS, its components, and cellular aging markers: leukocyte mitochondrial DNA copy number (mtDNAcn) and telomere length (TL). Methods: We included 989 participants from the Coronary Artery Risk Development in Young Adults Study. MtDNAcn (CARDIA Years 15, 25) and TL (Y15, Y20, Y25) were measured using quantitative PCR...
October 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29050797/25-year-physical-activity-trajectories-and-development-of-subclinical-coronary-artery-disease-as-measured-by-coronary-artery-calcium-the-coronary-artery-risk-development-in-young-adults-cardia-study
#19
Deepika R Laddu, Jamal S Rana, Rosenda Murillo, Michael E Sorel, Charles P Quesenberry, Norrina B Allen, Kelley P Gabriel, Mercedes R Carnethon, Kiang Liu, Jared P Reis, Donald Lloyd-Jones, J Jeffrey Carr, Stephen Sidney
OBJECTIVE: To evaluate 25-year physical activity (PA) trajectories from young to middle age and assess associations with the prevalence of coronary artery calcification (CAC). PATIENTS AND METHODS: This study includes 3175 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study who self-reported PA by questionnaire at 8 follow-up examinations over 25 years (from March 1985-June 1986 through June 2010-May 2011). The presence of CAC (CAC>0) at year 25 was measured using computed tomography...
November 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29049398/gravidity-is-not-associated-with-telomere-length-in-a-biracial-cohort-of-middle-aged-women-the-coronary-artery-risk-development-in-young-adults-cardia-study
#20
Abbi D Lane-Cordova, Eli Puterman, Erica P Gunderson, Cheeling Chan, Lifang Hou, Mercedes Carnethon
OBJECTIVE: Having experienced 2-3 births is associated with reduced mortality versus women with <2 or ≥4 births. The effect of 2-3 births on lifespan may be associated with delayed cellular aging. We hypothesized telomere length, a marker of cellular aging, would be longer in women who had 2-3 pregnancies. METHODS: Leukocyte telomere length was measured using quantitative real-time polymerase chain reaction in 620 women in CARDIA at the year 15 and 20 exams, expressed as the ratio of telomere repeat copy number to single-copy gene copy number (T/S)...
2017: PloS One
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