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Bilateral common carotid artery stenosis

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https://www.readbyqxmd.com/read/28670274/differentially-severe-cognitive-effects-of-compromised-cerebral-blood-flow-in-aged-mice-association-with-myelin-degradation-and-microglia-activation
#1
Gilly Wolf, Amit Lotan, Tzuri Lifschytz, Hagar Ben-Ari, Tirzah Kreisel Merzel, Pavel Tatarskyy, Michael Valitzky, Ben Mernick, Elad Avidan, Nickolay Koroukhov, Bernard Lerer
Bilateral common carotid artery stenosis (BCAS) models the effects of compromised cerebral blood flow on brain structure and function in mice. We compared the effects of BCAS in aged (21 month) and young adult (3 month) female mice, anticipating a differentially more severe effect in the older mice. Four weeks after surgery there was a significant age by time by treatment interaction on the radial-arm water maze (RAWM; p = 0.014): on the first day of the test, latencies of old mice were longer compared to the latencies of young adult mice, independent of BCAS...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28655874/long-term-cilostazol-treatment-reduces-gliovascular-damage-and-memory-impairment-in-a-mouse-model-of-chronic-cerebral-hypoperfusion
#2
Akihiro Kitamura, Yasmina Manso, Jessica Duncombe, James Searcy, Juraj Koudelka, Margaret Binnie, Scott Webster, Ross Lennen, Maurits Jansen, Ian Marshall, Masafumi Ihara, Raj N Kalaria, Karen Horsburgh
Chronic cerebral hypoperfusion is a major cause of age-related vascular cognitive impairment. A well-characterised mouse model has shown that hypoperfusion results in gliovascular and white matter damage and impaired spatial working memory. In this study, we assessed whether cilostazol, a phosphodiesterase III inhibitor, could protect against these changes. Adult, male C57Bl/6J mice were subjected to bilateral common carotid artery stenosis or a sham operation and fed normal or cilostazol diet for three months...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28625130/remote-ischemic-conditioning-improves-cognitive-function-during-cerebral-vascular-injury-through-the-induction-of-autophagy
#3
Hongjuan Wang, Qinglin Zhang, Yang Xu, Hetao Bian, Cuiping Si, Zhongrui Yan, Meijia Zhu
BACKGROUND: The most valid model for vascular cognitive impairment (VCI) is the mouse bilateral common carotid artery stenosis (BCAS), whose behavioral outcomes is supposedly affected by the remote ischemic conditioning (RIC) through the induction of autophgy. We hope to determine whether RIC contributes to the neuroprotection through the induction of autophagy.. METHODS: Wastar male mice were randomized into three groups including the Sham, the BCAS and the RIC+BCAS groups...
June 18, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28620501/efficacy-of-lenvatinib-in-a-patient-with-anaplastic-thyroid-cancer
#4
Kazuyuki Oishi, Daisuke Takabatake, Yuichi Shibuya
We experienced a case of an 82-year-old woman who presented to our hospital with a 1-month history of dysphagia and dyspnea. Cervical contrast-enhanced computed tomography revealed diffuse thyroid neoplasms causing significant tracheal stenosis with tumors, particularly of the superior mediastinum, which were associated with an embolism of the brachiocephalic vein and suspected invasion to the bilateral common carotid arteries. Anaplastic thyroid cancer (ATC) was diagnosed by fine-needle aspiration; thus, emergency tracheostomy and gastrostomy were performed...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28606007/dimethyl-fumarate-improves-white-matter-function-following-severe-hypoperfusion-involvement-of-microglia-macrophages-and-inflammatory-mediators
#5
Jill H Fowler, Jamie McQueen, Philip R Holland, Yasmina Manso, Martina Marangoni, Fiona Scott, Emma Chisholm, Robert H Scannevin, Giles E Hardingham, Karen Horsburgh
The brain's white matter is highly vulnerable to reductions in cerebral blood flow via mechanisms that may involve elevated microgliosis and pro-inflammatory pathways. In the present study, the effects of severe cerebral hypoperfusion were investigated on white matter function and inflammation. Male C57Bl/6J mice underwent bilateral common carotid artery stenosis and white matter function was assessed at seven days with electrophysiology in response to evoked compound action potentials (CAPs) in the corpus callosum...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28578987/chronic-cerebral-hypoperfusion-independently-exacerbates-cognitive-impairment-within-the-pathopoiesis-of-parkinson-s-disease-via-microvascular-pathologys
#6
Hongmei Tang, Yuyuan Gao, Qingxi Zhang, Kun Nie, Ruiming Zhu, Liang Gao, Shujun Feng, Limin Wang, Jiehao Zhao, Zhiheng Huang, Yuhu Zhang, Lijuan Wang
To date, the role of microvascular pathology and chronic cerebral hypoperfusion (CHH) in the development of mild cognitive impairment in Parkinson's disease (PD-MCI) is unclear. Here, we investigated how the combined injury through interaction of CHH and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity act as an exacerbating element to damagae cognitive fuction in a mouse model. In the present study, C57BL/6 mice underwent MPTP injection. Subjects were classified into a PD with normal cognitive performance (PDCN) group or a PD-MCI group using the Morris Water Maze test...
June 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28554699/-prevalence-of-carotid-artery-stenosis-in-nonagenarians-survey-in-a-primary-care-hospital
#7
J Bohlender, J Nussberger, J Ménard, B Bohlender
AIM: Carotid artery stenosis increases with age and may cause brain ischemia if arterial hypotension occurs. We performed a monocentric pilot study to investigate its prevalence in the very elderly and to assess its potential influence on blood pressure (BP) goals during antihypertensive treatment. METHODS: All patients≥90 years of a primary care medical ward were prospectively included over 15 months. Ultrasound exams of the precerebral arteries were offered to all elderly patients for routine evaluation of their cardiovascular risk...
June 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28479775/surgical-revascularization-of-bilateral-renal-artery-stenosis-due-to-fibromuscular-dysplasia
#8
Chandan Phukan, Arun J P George, J Chandrasingh, Antony Devasia
Fibromuscular dysplasia (FMD) is a noninflammatory disease affecting small- and medium-sized arteries of the renal and the carotids. It affects the renal arteries in nearly 60%-75% cases. The primary clinical manifestation of renal FMD is hypertension. Medial fibroplasia represents the most common dysplastic lesion. We report two cases who presented with hypertension and renal insufficiency and on evaluation was found to have bilateral renal artery stenosis. Stenting of the renal vessels was not possible due to the narrowed caliber of the vessel and inability to cannulate the renal arteries...
April 2017: Urology Annals
https://www.readbyqxmd.com/read/28470822/pericyte-derived-bone-morphogenetic-protein-4-underlies-white-matter-damage-after-chronic-hypoperfusion
#9
Maiko T Uemura, Masafumi Ihara, Takakuni Maki, Takayuki Nakagomi, Seiji Kaji, Kengo Uemura, Tomohiro Matsuyama, Raj N Kalaria, Ayae Kinoshita, Ryosuke Takahashi
Subcortical small vessel disease (SVD) is characterized by white matter damage resulting from arteriolosclerosis and chronic hypoperfusion. Transforming growth factor beta 1 (TGFB1) is dysregulated in the hereditary SVD, CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy). However, very little is known about the role of the largest group in the TGFB superfamily - the bone morphogenetic proteins (BMPs) - in SVD pathogenesis. The aim of this study was to characterize signaling abnormalities of BMPs in sporadic SVD...
May 4, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28399892/effects-of-environmental-enrichment-on-white-matter-glial-responses-in-a-mouse-model-of-chronic-cerebral-hypoperfusion
#10
Yoshiki Hase, Lucinda Craggs, Mai Hase, William Stevenson, Janet Slade, Dianne Lopez, Rubin Mehta, Aiqing Chen, Di Liang, Arthur Oakley, Masafumi Ihara, Karen Horsburgh, Raj N Kalaria
BACKGROUND: This study was designed to explore the beneficial effects of environmental enrichment (EE) on white matter glial changes in a mouse model of chronic cerebral hypoperfusion induced by bilateral common carotid artery stenosis (BCAS). METHODS: A total of 74 wild-type male C57BL/6J mice underwent BCAS or sham surgery. One week after surgery, the mice were randomly assigned into three different groups having varied amounts of EE-standard housing with no EE conditions (std), limited exposure with 3 h EE a day (3 h) and full-time exposure to EE (full) for 12 weeks...
April 11, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28382613/reduced-internal-carotid-artery-flow-in-color-coded-carotid-duplex-sonography
#11
Fu-Yi Yang, Po-Ren Hsu, Shinn-Kuang Lin
PURPOSE: Reduced flow in the internal carotid artery (ICA) is related to cerebral ischemia. We established a classification of reduced ICA flow through color-coded carotid duplex (CCD) sonography. METHODS: We retrospectively reviewed 25,000 CCD images in sonography laboratory. RESULTS: Reduced ICA flow [flow volume (FV) less than 100 mL/min] was found in 1.2% of all studies, and 270 patients were enrolled. We included 8% patients with lesions proximal to the ICA in Group A, 27% with lesions at the proximal ICA in Group B, 49% with lesions distal to the visible ICA in Group C, and 16% with unknown causes in Group D...
December 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/28273725/the-effects-of-environmental-enrichment-on-white-matter-pathology-in-a-mouse-model-of-chronic-cerebral-hypoperfusion
#12
Yoshiki Hase, Lucinda Craggs, Mai Hase, William Stevenson, Janet Slade, Aiqing Chen, Di Liang, Abdel Ennaceur, Arthur Oakley, Masafumi Ihara, Karen Horsburgh, Raj N Kalaria
White matter (WM) disintegration is common in the older population and is associated with vascular cognitive impairment (VCI). This study explored the effects of environmental enrichment (EE) on pathological sequelae in a mouse model of chronic cerebral hypoperfusion induced by bilateral common carotid artery stenosis (BCAS). Male C57BL/6 J mice underwent BCAS or sham surgery. One-week after surgery, mice were exposed to three different degrees of EE; either standard housing conditions (std), limited 3 h exposure to EE per day (3 h) or full-time exposure to EE (full) for 12 weeks...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28219575/how-to-clamp-and-bypass-if-there-is-single-artery-supply-to-the-head-and-that-contains-severe-stenosis
#13
Murat Ugurlucan, Yilmaz Onal, Didem Melis Oztas, Omer Ali Sayin, Kubilay Aydin, Ufuk Alpagut
Takayasu arteritis manifests with arterial occlusions and aneurysms. Revascularization is sometimes challenging, especially when carotid arteries are affected. In this report, we present a carotid artery revascularization technique in a patient who was admitted with orthostatic and postprandial transient ischemic attacks, resulting in a diagnosis of bilaterally occluded subclavian and vertebral arteries, occluded left common carotid artery, and severely stenosed right common carotid artery. Clamping of the right carotid artery was a challenge; however, our technique provides a neurologically safe revascularization...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28178896/sequential-pet-estimation-of-cerebral-oxygen-metabolism-with-spontaneous-respiration-of-15-o-gas-in-mice-with-bilateral-common-carotid-artery-stenosis
#14
Takashi Temma, Makoto Yamazaki, Jun Miyanohara, Hisashi Shirakawa, Naoya Kondo, Kazuhiro Koshino, Shuji Kaneko, Hidehiro Iida
Positron emission tomography with (15)O-labeled gases ((15)O-PET) is important for in vivo measurement of cerebral oxygen metabolism both in clinical and basic settings. However, there are currently no reports concerning (15)O-PET in mice. Here, we developed an (15)O-PET method applicable to mice with spontaneous respiration of (15)O-gas without a tracheotomy catheter. Sequential (15)O-PET was also performed in a mouse model of chronic cerebral hypoperfusion with bilateral common carotid artery stenosis (BCAS) induced by placement of microcoils...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27994990/refractory-case-of-takayasu-arteritis-in-a-young-woman-a-clinical-challenge
#15
Mudassar Ahmed, Salman Mansoor, Salman Assad, Shahar Y Khan, Rizwanullah Khan, Usman Ghani, Taimur Mansoor, Aasim Rehman
Takayasu arteritis (TA) is an idiopathic chronic inflammatory vasculitis of the aorta and its main branches, which if not treated can lead to severe vascular damage and fatal vascular events. Glucocorticoids (GCs) are the mainstay of the therapy of TA but a significant proportion of patients tend to experience flare-ups when their GCs are tapered. We report a case of a 42-year-old female with TA, diagnosed according to the 1990 American College of Rheumatology Criteria for TA. Cardiovascular assessment showed normal carotid upstrokes with bilateral carotid bruits and soft right and left subclavian bruits with weak peripheral pulses...
November 9, 2016: Curēus
https://www.readbyqxmd.com/read/27916638/therapeutical-options-in-the-management-of-carotid-dissection
#16
Ombretta Martinelli, Salvatore Venosi, Jamila BenHamida, Alban Malaj, Cristina Belli, Francesco Giosue' Irace, Roberto Gattuso, Giacomo Frati, Bruno Gossetti, Luigi Irace
BACKGROUND: The best management of carotid artery dissection (CAD) is still controversial ranging from antiplatelet medication to open surgery or endovascular treatment. In this retrospective study, we assessed the safety and efficacy of endovascular stent angioplasty for the treatment of CAD. METHODS: From February 2006 to February 2016, 44 patients (28 women and 16 men, age range 25-65 years, mean 42) with CAD were included in this study. The internal carotid artery dissection was spontaneous in 32 patients and posttraumatic in the remaining 12 (in 1 case, it was bilateral)...
May 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27754070/os-18-02-antihypertensive-treatment-and-risk-of-brain-ischemia-due-to-carotid-stenosis-in-a-survey-of-hospitalised-patients-aged-90-years-and-older
#17
Jürgen Bohlender, Jürg Nussberger, Beate Bohlender
OBJECTIVE: In elderly hypertensive patients, systolic blood pressure (sBP) goals recommended by US and European guidelines (ESH) for the initiation of treatment are more liberal than in younger patients because of an increased risk of treatment-associated side-effects and hypotension. Carotid stenosis increases with age and poses a risk of brain ischemia if hypotension occurs. Its relevance for the routine care of elderly hypertensives, however, remains unclear. We analyzed data on precerebral artery morphology and BP evolution from a survey of aged hospitalized patients...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27699162/bovine-aortic-arch-and-bilateral-retroesophageal-course-of-common-carotid-arteries-in-a-symptomatic-patient
#18
Daniele Bissacco, Maurizio Domanin, Giuseppina Schinco, Livio Gabrielli
Anatomical variations of carotid arteries may be related to their development (agenesis, aplasia, hypoplasia) or course (coiling, kinking, tortuosity). Partial or total aberrancies in carotid vessel anatomy rarely occur. We describe the case of a 95-year-old woman presented with sudden onset of confusion and disorientation together with upper limb clonus. Computed tomography (CT)-scan revealed a left frontal brain injury with a not conclusive carotid doppler ultrasound. CT angiography reported a bovine aortic arch with bilateral retroesophageal course of both common carotid arteries and left severe (>70%) internal carotid artery stenosis...
September 2016: Vascular Specialist International
https://www.readbyqxmd.com/read/27649086/the-number-of-stenotic-intracranial-arteries-is-independently-associated-with-ischemic-stroke-severity
#19
Xiaodan Wei, Zhuang Liu, Min Li, Chunhua Yang, Wenming Wang, Xianglin Li, Shuping Zhang, Xuri Li, Geng Tian, Jonas Bergquist, Bin Wang, Jia Mi
BACKGROUND: The severity of ischemic stroke symptoms varies among patients and is a critical determinant of patient outcome. To date, the association between the number of stenotic intracranial arteries and stroke severity remains unclear. AIMS: We aimed to investigate the association between the number of stenotic major intracranial arteries (NSMIA) and ischemic stroke severity, as well as the degree of stenosis and common stroke risk factors. METHODS: We performed a retrospective analysis of patients with digital subtraction angiography (DSA)-confirmed ischemic stroke...
2016: PloS One
https://www.readbyqxmd.com/read/27642991/os-18-02-antihypertensive-treatment-and-risk-of-brain-ischemia-due-to-carotid-stenosis-in-a-survey-of-hospitalised-patients-aged-90-years-and-older
#20
Jürgen Bohlender, Jürg Nussberger, Beate Bohlender
OBJECTIVE: In elderly hypertensive patients, systolic blood pressure (sBP) goals recommended by US and European guidelines (ESH) for the initiation of treatment are more liberal than in younger patients because of an increased risk of treatment-associated side-effects and hypotension. Carotid stenosis increases with age and poses a risk of brain ischemia if hypotension occurs. Its relevance for the routine care of elderly hypertensives, however, remains unclear. We analyzed data on precerebral artery morphology and BP evolution from a survey of aged hospitalized patients...
September 2016: Journal of Hypertension
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