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Sahar Moradi, Ali Akbar Zinatizadeh, Sirus Zinadini
Polymeric membranes have garnered great interest in wastewater treatment; however, fouling is known as their main limitation. Therefore, the blending of hydrophilic nanoparticles in polymeric membranes' structure is a promising approach for fouling reduction. Herein, a hydrophilic boehmite-tannic acid-graphene quantum dot (BM-TA-GQD) nanoparticle was synthesized and blended in a polyethersulfone polymeric membrane in different percentages. The fabricated membranes were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM) images, water contact angle, porosity measurement, and antibacterial and antifouling properties...
February 2024: Water Environment Research: a Research Publication of the Water Environment Federation
#22
JOURNAL ARTICLE
Zichao Huang, Xinyu Zhuang, Liping Liu, Jiayu Zhao, Sheng Ma, Xinghui Si, Zhenyi Zhu, Fan Wu, Ningyi Jin, Mingyao Tian, Wantong Song, Xuesi Chen
Virus-like particle (VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However, the time-consuming and complicated processes in establishing a current recombinant-protein-based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine (VPNVax), with subunit receptor-binding domain (RBD) proteins conjugated to the surface of polyethylene glycol- b -polylactic acid (PEG- b -PLA) nanoparticles for vaccination against SARS-CoV-2...
March 2024: National Science Review
#23
JOURNAL ARTICLE
Z Z Yan, Y X Wang, T L Zhang, J N Xun, Y C Ma, C Ji, J Gao, S C Xiao
Objective: To explore the properties of gelatin-polyethylene glycol hydrogel loaded with silver nanoparticle (AgNP) Chlorella (hereinafter referred to as the composite hydrogel) and its effects on healing of infected full-thickness skin defect wounds in mice. Methods: The research was an experimental research. The simple gelatin-polyethylene glycol hydrogel (hereinafter referred to as the simple hydrogel) and the composite hydrogel were prepared, and the appearance and injectability of the two hydrogels were observed at 55 and 37 ℃, and under the irradiation of 808 nm near-infrared light, respectively...
January 20, 2024: Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
#24
Sonia Jangra, Alexander Lamoot, Gagandeep Singh, Gabriel Laghlali, Yong Chen, Tingting Yz, Adolfo García-Sastre, Bruno G De Geest, Michael Schotsaert
Adjuvants can enhance vaccine effectiveness of currently licensed influenza vaccines. We tested influenza vaccination in a mouse model with two adjuvants: Sendai virus derived defective interfering (SDI) RNA, a RIG-I agonist, and an amphiphilic imidazoquinoline (IMDQ-PEG-Chol), TLR7/8 adjuvant. The negatively charged SDI RNA was formulated into lipid nanoparticles (LNPs) facilitating the direct delivery of a RIG-I agonist to the cytosol. We have previously tested SDI and IMDQ-PEG-Chol as standalone and combination adjuvants for influenza and SARS-CoV-2 vaccines...
January 15, 2024: bioRxiv
#25
JOURNAL ARTICLE
Eunseo Choi, Jeong-Min Park, Geun Young Kim, Hyun-Seok Choe, Han-Gil Kim, Jae-Hyuk Kim
The post-encapsulation method (such as single-layered encapsulation) is a promising strategy to synthesize yolk-shell structures that protect functional nanoparticles by the molecular sieving effect. However, this method exhibited limited loading capacity and nonuniform encapsulation during the co-encapsulation of various nanoparticles owing to the insufficient surface area for nanoparticle attachment. To address these limitations, we proposed a double-layered encapsulation method comprising an increased number of silica template layers and separate attachment of multifarious nanoparticles to different layers...
January 30, 2024: Journal of Physical Chemistry Letters
#26
JOURNAL ARTICLE
Zhengjia Zhang, Xinyi Luo, Xiaoxia Xue, Mingshi Pang, Xiangpeng Wang, Liuchunyang Yu, Jinxiu Qian, Xiaoyu Li, Meng Tian, Aiping Lu, Cheng Lu, Yuanyan Liu
BACKGROUND: The morbidity and mortality of triple-negative breast cancer (TNBC) are still high, causing a heavy medical burden. CCL5, as a chemokine, can be involved in altering the composition of the tumor microenvironment (TME) as well as the immunosuppressive degree, and has become a very promising target for the treatment of TNBC. Dysregulation of microRNAs (miRNAs) in tumor tissues is closely related to tumor progression, and its utilization can be used to achieve therapeutic purposes...
2024: International Journal of Nanomedicine
#27
JOURNAL ARTICLE
Jingqu Chen, Christina Cortez-Jugo, Chan-Jin Kim, Zhixing Lin, Tianzheng Wang, Robert De Rose, Wanjun Xu, Zhaoran Wang, Yuang Gu, Frank Caruso
Small molecules, including therapeutic drugs and tracer molecules, play a vital role in biological processing, disease treatment and diagnosis, and have inspired various nanobiotechnology approaches to realize their biological function, particularly in drug delivery. Desirable features of a delivery system for functional small molecules (FSMs) include high biocompatibility, high loading capacity, and simple manufacturing processes, without the need for chemical modification of the FSM itself. Herein, we demonstrate a simple and versatile approach, based on metal-phenolic-mediated assembly, for assembling FSMs into nanoparticles (i...
January 28, 2024: Angewandte Chemie
#28
JOURNAL ARTICLE
Salem Almoammar, Muhammad Abdullah Kamran, Abdullah A Alnazeh, Mohammad Almagbol, Mohammed Mohsen Al Jearah, Master Luqman Mannakandath
Zirconium dioxide silver-doped nanoparticles (ZrO2 AgDNPs) impacts the adhesive material in terms of its physical characteristics, antimicrobial properties, degree of conversion (DC), and micro-tensile bond strength (μTBS) of orthodontic brackets to the enamel surface. A comprehensive methodological analysis utilizing a range of analytical techniques, including scanning electron microscopy coupled with energy-dispersive x-ray spectroscopy (EDX), Fourier-transform infrared (FTIR) spectroscopy, DC analysis, and μTBS testing...
January 26, 2024: Microscopy Research and Technique
#29
JOURNAL ARTICLE
Ruiyin Zeng, Bin Lv, Ze Lin, Xiangyu Chu, Yuan Xiong, Samuel Knoedler, Faqi Cao, Chuanlu Lin, Lang Chen, Chenyan Yu, Jiewen Liao, Wu Zhou, Guandong Dai, Mohammad-Ali Shahbazi, Bobin Mi, Guohui Liu
Oxidative stress, infection, and vasculopathy caused by hyperglycemia are the main barriers for the rapid repair of foot ulcers in patients with diabetes mellitus (DM). In recent times, the discovery of neddylation, a new type of post-translational modification, has been found to regulate various crucial biological processes including cell metabolism and the cell cycle. Nevertheless, its capacity to control the healing of wounds in diabetic patients remains unknown. This study shows that MLN49224, a compound that inhibits neddylation at low concentrations, enhances the healing of diabetic wounds by inhibiting the polarization of M1 macrophages and reducing the secretion of inflammatory factors...
April 2024: Bioactive Materials
#30
JOURNAL ARTICLE
Nada Al-Saran, Pandurangan Subash-Babu, Laila Naif Al-Harbi, Bahauddeen M Alrfaei, Ali A Alshatwi
The primary pathological hallmark of Alzheimer's disease (AD) is the formation and accumulation of neurofibrillary tangles and plaques, which result from the aggregation of amyloid- β (A β ) induced by oxidative stress. The effectiveness of Alzheimer's disease (AD) therapeutics significantly hinges on the drug's bioavailability and its ability to penetrate neuronal cells. The current investigation was designed as a first attempt to examine bio-fabricated Lepidium sativum (LS) seed-extract-loaded solid lipid nanoparticles (SLNps) to increase bioavailability and bioefficacy for the prevention of undifferentiated SH-SY5Y neuronal cells from oxidative stress induced by H2 O2 and amyloid- β peptide (A β ,1-42)...
January 16, 2024: Nanomaterials
#31
JOURNAL ARTICLE
Huihui Xu, Lishan Yuan, Qiankun Shi, Ye Tian, Fang Hu
Fluorescence imaging is a vital way to delineate the tumor boundaries. Here, we achieve a NIR-II aggregation-induced emission luminogen (AIEgen) with a fluorescence quantum yield (QY) of 12.6% in water through straightforward alkyl side chain modification. After loading of NIR-II AIEgen into polystyrene (PS) nanospheres, the thermal deactivation pathway is extremely limited, thereby concentrating absorption excitation on fluorescence emission. The fluorescence intensity is further enhanced by 5.4 times, the QY increases to 21...
January 16, 2024: Nano Letters
#32
JOURNAL ARTICLE
Chuan Zhang, Kaixin Zheng, Chi Li, Ranran Zhang, Yicheng Zhu, Linxiao Xia, Yicheng Ma, Hans M Wyss, Xiaoyu Cheng, Sailing He
Detecting proteins in ultralow concentrations in complex media is important for many applications but often relies on complicated techniques. Herein, a single-molecule protein analyzer with the potential for high-throughput applications is reported. Gold-coated magnetic nanoparticles with DNA-labeled antibodies were used for target recognition and separation. The immunocomplex was loaded into microdroplets generated with centrifugation. Immuno-PCR amplification of the DNA enabled the quantification of proteins at the level of single molecules...
January 15, 2024: Analytical Chemistry
#33
JOURNAL ARTICLE
Nourah A Al Zahrani, Mohamed M Gad, Ahmed M Fikry, Ahmed Ezzat Ahmed, Khaled A El-Tarabily, Hend A Elakkad, Ibrahim Eid Elesawi
Because of its high degree of biodegradability, chitosan is widely used as a component in food packaging. However, its poor physical properties, such as permeability, limit its applicability. Consequently, applying nano chitosan is regarded as the most effective solution to this issue. In the current study, we studied the effect of using different materials in the coating process on the quality of " Murcott " mandarin during cold storage. We used different concentrations of nano chitosan (50 and 100 ppm) without wax and 100 ppm nano chitosan with wax...
February 2024: Saudi Journal of Biological Sciences
#34
JOURNAL ARTICLE
Barakat M ALRashdi, Mohamed M Hussein, Rawan M Mohammed, Nada W Abdelhamed, Maran E Asaad, Mubarak Alruwaili, Saad M Alrashidi, Ola A Habotta, Ahmed Abdel Moneim, Shimaa S Ramadan
BACKGROUND: Doxorubicin (DOX) is an antitumor anthracycline used to treat a variety of malignancies; however, its clinical use is associated with noticeable hepatotoxicity. Therefore, the current study was designed to delineate if biosynthesized SeNPs with turmeric extract (Tur-SeNPs) could alleviate DOX-induced hepatic adverse effects. METHODS: Mice were orally post-treated with Tur extract, Tur-SeNPs, or N-acetyl cysteine after the intraperitoneal injection of DOX...
January 9, 2024: Anti-cancer Agents in Medicinal Chemistry
#35
JOURNAL ARTICLE
Urushi Rehman, Afsana Sheikh, Abdulrhman Alsayari, Shadma Wahab, Prashant Kesharwani
Wounds are a physical manifestation of injury to the skin causing it to rupture or tear. The process of wound healing naturally restores skin integrity while minimizing the extent of the damage. Hesperidin (HPN) is a natural polyphenolic flavonoid and is effective in treating wounds due to its ability to reduce inflammation and stimulate angiogenesis. However, its use is limited by its poor physicochemical attributes such as poor solubility in water. Recently, nanoparticles, particularly Cubosomes, are found to be promising candidates for advancing wound-healing therapies, owing to their unique properties...
December 26, 2023: Colloids and Surfaces. B, Biointerfaces
#36
JOURNAL ARTICLE
Nursu Erdoğan, Didem Şen Karaman, Özlem Yıldız, Gizem Dilara Özdemir, Utku Kürşat Ercan
Nanofibers (NF) and nanoparticles are attractive in the field of drug delivery especially to improve the drug bioavailability and administration. Easy manipulation of polymeric fibers as macroscopic bulk material may give rise to potential uses as implantable local drug delivery platforms. In this study, poly(ethylene glycol) polyethyleneimine (mPEG: PEI) copolymer blended poly ε-caprolactone (PCL) nanofibers, NFblend accommodating mesoporous silica nanoparticles (MSN) as the implantable local drug delivery system was achieved by employing spin coating and cold atmospheric plasma (CAP) post-processing...
January 5, 2024: Biomedical Materials
#37
JOURNAL ARTICLE
Crescenzo Frascogna, Rocco Mottareale, Giuseppe La Verde, Cecilia Arrichiello, Paolo Muto, Paolo A Netti, Mariagabriella Pugliese, Valeria Panzetta
The biological effects of ionizing radiation are exploited in the clinical practice of radiotherapy to destroy tumour cells while sparing the surrounding normal tissue. While most of the radiotherapy research focused on DNA damage and repair, recently a great attention is going to cells' interactions with the mechanical microenvironment of both malignant and healthy tissues after exposure. In fact, the stiffness of the extracellular matrix can modify cells' motility and spreading through the modulation of transmembrane proteins and surface receptors' expression, such as CD-44...
January 3, 2024: Scientific Reports
#38
JOURNAL ARTICLE
Alessio Alogna, Leonhard Berboth, Alessandro Faragli, Jens Ötvös, Francesco Paolo Lo Muzio, Vittoria di Mauro, Jessica Modica, Eride Quarta, Lukas Semmler, Peter Maximilian Deißler, Yannic Wanja Berger, Khai Liem Tran, Beatrice de Marchi, Gianluigi Longinotti-Buitoni, Lorenzo Degli Esposti, Etienne Guillot, Didier Bazile, Michele Iafisco, Alessandro Dotti, Marie-Louise Bang, Claudio de Luca, Christina Brandenberger, Louise Benazzi, Dario di Silvestre, Antonella de Palma, Uwe Primeßnig, Felix Hohendanner, Simone Perna, Francesca Buttini, Paolo Colombo, Christian Mühlfeld, Paul Steendijk, Pierluigi Mauri, Carsten Tschöpe, Barry Borlaug, Burkert M Pieske, Philipp Attanasio, Heiner Post, Frank R Heinzel, Daniele Catalucci
BACKGROUND: The lack of disease-modifying drugs is one of the major unmet needs in patients with heart failure (HF). Peptides are highly selective molecules with the potential to act directly on cardiomyocytes. However, a strategy for effective delivery of therapeutics to the heart is lacking. OBJECTIVES: In this study, the authors sought to assess tolerability and efficacy of an inhalable lung-to-heart nano-in-micro technology (LungToHeartNIM) for cardiac-specific targeting of a mimetic peptide (MP), a first-in-class for modulating impaired L-type calcium channel (LTCC) trafficking, in a clinically relevant porcine model of HF...
January 2, 2024: Journal of the American College of Cardiology
#39
JOURNAL ARTICLE
Doaa Ibrahim, Mona Mohammed I Abdel Rahman, Amany M Abd El-Ghany, Eman A A Hassanen, Omar A Al-Jabr, Reham A Abd El-Wahab, Shimaa Zayed, Mona Abd El Khalek Salem, Shimaa Nabil El Tahawy, Wessam Youssef, Heba A Tolba, Rehab E Dawod, Rahma Taha, Ahmed H Arisha, Asmaa T Y Kishawy
Nile tilapia reared under intensive conditions was more susceptible for Ichthyophthirius multifilii (I. multifiliis) infection eliciting higher mortality, lower productive rate and further bacterial coinfection with Aeromonas hydrophila (A. hydrophila). The higher potency of magnetic field of iron oxide nanoparticles (NPs) can kill pathogens through inhibiting their viability. Herein, coating of Chlorella vulgaris extract (ChVE) with magnetic iron oxide NPs (Mag iron NPs) can create an external magnetic field that facilitates their release inside the targeted tissues...
January 1, 2024: Fish & Shellfish Immunology
#40
JOURNAL ARTICLE
Nadia Alansari, Mushriq Abid, Arkadiusz Dziedzic
AIMS AND OBJECTIVE: Presurgical infant's orthopedic appliances (PSIOs) play an increasingly crucial role in the interdisciplinary management of neonatal CLP, aiming to improve and maintain adequate nasolabial aesthetics, followed by primary lip/nasal surgery in both unilateral and bilateral CLP cases. The use of PSIOs in cleft lip and palate patients can lead to contamination with oral microflora, acting as a potential reservoir for infectious microorganisms. Acrylic surfaces might provide retention niches for microorganisms to adhere, and inhabit, which is difficult to control in immunocompromised patients, thus predisposing them to increased infection risks...
January 2, 2024: Clinical Oral Investigations
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