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Post-loaded nanoparticle

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https://www.readbyqxmd.com/read/29141151/light-responsive-nanoparticles-for-highly-efficient-cytoplasmic-delivery-of-anticancer-agents
#1
Yangyun Wang, Yibin Deng, Huanhuan Luo, Aijun Zhu, Hengte Ke, Hong Yang, Huabing Chen
Stimuli-responsive nanostructures have shown great promise for intracellular delivery of anticancer compounds. A critical challenge remains in the exploration of stimuli-responsive nanoparticles for fast cytoplasmic delivery. Herein, near-infrared (NIR) light-responsive nanoparticles were rationally designed to generate highly efficient cytoplasmic delivery of anticancer agents for synergistic thermo-chemotherapy. The drug-loaded polymeric nanoparticles of selenium-inserted copolymer (I/D-Se-NPs) were rapidly dissociated in several minutes through reactive oxygen species (ROS)-mediated selenium oxidation upon NIR light exposure, and this irreversible dissociation of I/D-Se-NPs upon such a short irradiation promoted continuous drug release...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29109782/berunda-polypeptides-multi-headed-fusion-proteins-promote-subcutaneous-administration-of-rapamycin-to-breast-cancer-in-vivo
#2
Jugal P Dhandhukia, Zhe Li, Santosh Peddi, Shruti Kakan, Arjun Mehta, David Tyrpak, Jordan Despanie, J Andrew MacKay
Recombinant Elastin-Like Polypeptides (ELPs) serve as attractive scaffolds for nanoformulations because they can be charge-neutral, water soluble, high molecular weight, monodisperse, biodegradable, and decorated with functional proteins. We recently reported that fusion of the FK-506 binding protein 12 (FKBP) to an ELP nanoparticle (FSI) reduces rapamycin (Rapa) toxicity and enables intravenous (IV) therapy in both a xenograft breast cancer model and a murine autoimmune disease model. Rapa has poor solubility, which leads to variable oral bioavailability or drug precipitation following parenteral administration...
2017: Theranostics
https://www.readbyqxmd.com/read/28966368/in-situ-formation-of-holmium-oxide-in-pores-of-mesoporous-carbon-nanoparticles-as-substrates-for-neutron-activatable-radiotherapeutics
#3
Junghyun Kim, Zhi-Xiang Luo, Yue Wu, Xiuling Lu, Michael Jay
Radionuclide therapy with nano-sized carriers is a very promising approach to treat various types of cancer. The preparation of radioactive nanocarriers can be achieved with minimum handling using a neutron-activation approach. However, the nanocarrier material must possess certain characteristics such as low density, heat-resistance, high metal adsorption, easy surface modification and low toxicity in order to be useful. Mesoporous Carbon Nanoparticles (MCNs) in which holmium oxide is formed in their pores by a wet-impregnation process are investigated as a suitable material for this application...
June 2017: Carbon
https://www.readbyqxmd.com/read/28932197/antiplasmodial-activity-and-toxicological-assessment-of-curcumin-plga-encapsulated-nanoparticles
#4
Zulaikha A Busari, Kabiru A Dauda, Olajumoke A Morenikeji, Funmilayo Afolayan, Oyetunde T Oyeyemi, Jairam Meena, Debasis Sahu, Amulya K Panda
Curcumin is a polyphenolic pigment isolated from the rhizomes of Curcuma longa (turmeric), a medicinal plant widely used in the ancient Indian and Chinese medicine. The antiplasmodial activity of curcumin is often hampered by its fast metabolism and poor water solubility, thus its incorporation into a delivery system could circumvent this problem. This study aimed to evaluate the in vivo antiplasmodial activity and the toxicity assessment of curcumin incorporated into poly (lactic-co-glycolic) acid (PLGA) nanoparticles...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28917846/an-efficient-chitosan-derived-carbon-silica-microspheres-supported-pd-catalyst-with-high-stability-for-heck-reactions
#5
Yechao Su, Luyao Ma, Jian Chen, Jianhong Xu
To maintain stability and activity in Heck-coupling reaction, a novel composite carrier with controllable uniform size, high complex ability and mechanical intensity was fabricated in microchannel using natural N-doped biomolecule chitosan and silica as ingredients. Post carbonization increased its thermal stability and supported Pd@C/silica catalysts can be acquired after Pd loading. Only 2mg supported Pd@C/silica catalysts (0.44μmol) can achieve high yield (>95%) in a typical Heck-coupling reaction and maintained activity even after 8 times of recycling...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28900598/cationic-pegylated-polycaprolactone-nanoparticles-carrying-post-operation-docetaxel-for-glioma-treatment
#6
Cem Varan, Erem Bilensoy
Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development of drug delivery systems is important to treat brain tumors and prevent tumor recurrence. The aim of this study was to develop core-shell polymeric nanoparticles with positive charge by employing a chitosan coating. Additionally, an implantable formulation for the chemotherapeutic nanoparticles was developed as a bioadhesive film to be applied at the tumor site following surgical operation for brain glioma treatment...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28883727/vaccination-with-poly-d-l-lactide-co-glycolide-nanoparticles-loaded-with-soluble-leishmania-antigens-and-modified-with-a-tnf%C3%AE-mimicking-peptide-or-monophosphoryl-lipid-a-confers-protection-against-experimental-visceral-leishmaniasis
#7
Maritsa Margaroni, Maria Agallou, Evita Athanasiou, Olga Kammona, Costas Kiparissides, Catherine Gaitanaki, Evdokia Karagouni
Visceral leishmaniasis (VL) persists as a major public health problem, and since the existing chemotherapy is far from satisfactory, development of an effective vaccine emerges as the most appropriate strategy for confronting VL. The development of an effective vaccine relies on the selection of the appropriate antigen and also the right adjuvant and/or delivery vehicle. In the present study, the protective efficacy of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), which were surface-modified with a TNFα-mimicking eight-amino-acid peptide (p8) and further functionalized by encapsulating soluble Leishmania infantum antigens (sLiAg) and monophosphoryl lipid A (MPLA), a TLR4 ligand, was evaluated against challenge with L...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28874692/silver-nanoparticle-loaded-collagen-chitosan-scaffolds-promote-wound-healing-via-regulating-fibroblast-migration-and-macrophage-activation
#8
Chuangang You, Qiong Li, Xingang Wang, Pan Wu, Jon Kee Ho, Ronghua Jin, Liping Zhang, Huawei Shao, Chunmao Han
Treatment of full-thickness skin defects poses significant clinical challenges including risk of infection and severe scaring. Silver nanoparticle (NAg), an effective antimicrobial agent, has provided a promising therapeutic method for burn wounds. However, the detailed mechanism remains unknown. Hence, we constructed a metallic nanosilver particles-collagen/chitosan hybrid scaffold (NAg-CCS) and investigated its potential effects on wound healing. In vitro scratch assay, immunofluorescence staining and antibacterial activity of the scaffold were all studied...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838233/intraorgan-targeting-of-gold-conjugates-for-precise-liver-cancer-treatment
#9
Yuan-Yue Gao, Huan Chen, Ying-Ying Zhou, Lin-Tao Wang, Yanglong Hou, Xing-Hua Xia, Ya Ding
Intraorgan targeting of chemical drugs at tumor tissues is essential in the treatment of solid tumors that express the same target receptor as normal tissues. Here, asialoglycoprotein receptor (ASGP-R)-targeting paclitaxel-conjugated gold nanoparticles (Gal/PTX-GNPs) are fabricated as a demonstration to realize the precise treatment of liver cancer. The enhanced biological specificity and therapeutic performance of drugs loaded on nanoparticles not only rely on the ligands on carriers for receptor recognition but are also determined by the performance of gold conjugates with designed structure...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28814137/pegylated-crosslinked-hyaluronic-acid-nanoparticles-designed-through-a-microfluidic-platform-for-nanomedicine
#10
Maria Russo, Anna Maria Grimaldi, Paolo Bevilacqua, Olimpia Tammaro, Paolo Antonio Netti, Enza Torino
AIM: A high versatile microfluidic platform is proposed to design, in a one-step strategy, PEGylated crosslinked hyaluronic acid nanoparticles (cHANPs) entrapping a magnetic resonance imaging contrast agent and a dye for multimodal imaging applications. MATERIALS & METHODS: Clinically relevant biomaterials were shaped in the form of spherical NPs through a microfluidic flow focusing approach. A comparison between post processing and simultaneous PEGylation is reported to evaluate the potentiality of the chemical decoration of the cHANPs in microfluidics...
September 2017: Nanomedicine
https://www.readbyqxmd.com/read/28809501/microencapsulated-solid-lipid-nanoparticles-as-a-hybrid-platform-for-pulmonary-antibiotic-delivery
#11
Diana P Gaspar, Maria Manuela Gaspar, Carla V Eleutério, Ana Grenha, Mateo Blanco, Lídia M D Gonçalves, Pablo Taboada, António J Almeida, Carmen Remuñán-López
Solid lipid nanoparticles (SLN) containing rifabutin (RFB), with pulmonary administration purposes, were developed through a technique that avoids the use of organic solvents or sonication. To facilitate their pulmonary delivery, the RFB-loaded SLN were included in microspheres of appropriate size using suitable excipients (mannitol and trehalose) through a spray-drying technique. Confocal analysis microscopy showed that microspheres are spherical and that SLN are efficiently microencapsulated and homogeneously distributed throughout the microsphere matrices...
August 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28806655/magnetic-reduced-graphene-oxide-loaded-hydrogels-highly-versatile-and-efficient-adsorbents-for-dyes-and-selective-cr-vi-ions-removal
#12
Fatima Halouane, Yavuz Oz, Dalila Meziane, Alexandre Barras, Jean Juraszek, Santosh K Singh, Sreekumar Kurungot, Pankaj K Shaw, Rana Sanyal, Rabah Boukherroub, Amitav Sanyal, Sabine Szunerits
The formation of composites of reduced graphene oxide (rGO) and magnetic nanoparticles (MP) has flourished in recent years as they combine the advantages of both nanomaterials. Most of these composite materials are prepared by in situ formation of MP onto rGO or by the post-adsorption onto rGO. We report here on a simple and highly controlled method for the fabrication of different magnetic 3D rGO-loaded hydrogels. Cellulose bound magnetic nanoparticles (MP@cellulose) were synthesized by chemical co-precipitation and loaded together with rGO into poly(ethylene glycol) dimethacrylate based hydrogels during their fabrication using photo-polymerization...
July 28, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28783304/post-polymerization-c-h-borylation-of-donor-acceptor-materials-gives-highly-efficient-solid-state-near-infrared-emitters-for-near-ir-oleds-and-effective-biological-imaging
#13
Daniel L Crossley, Laura Urbano, Robert Neumann, Struan Bourke, Jennifer Jones, Lea Ann Dailey, Mark Green, Martin J Humphries, Simon M King, Michael L Turner, Michael J Ingleson
Post-polymerization modification of the donor-acceptor polymer, poly(9,9-dioctylfluorene-alt-benzothiadiazole), PF8-BT, by electrophilic C-H borylation is a simple method to introduce controllable quantities of near-infrared (near-IR) emitting chromophore units into the backbone of a conjugated polymer. The highly stable borylated unit possesses a significantly lower LUMO energy than the pristine polymer resulting in a reduction in the band gap of the polymer by up to 0.63 eV and a red shift in emission of more than 150 nm...
August 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28776488/amino-functionalized-mesoporous-silica-nanoparticles-as-efficient-carriers-for-anticancer-drug-delivery
#14
Yongju He, Liangyu Luo, Shuquan Liang, Mengqiu Long, Hui Xu
Amino-functionalized mesoporous silica nanoparticles (MSN-NH2) were synthesized by a post-grafting method and further studied as carriers for doxorubicin hydrochloride (DOX) delivery. The morphology, structure, and property of MSN-NH2 and DOX-loaded MSN-NH2 (DOX@MSN-NH2) were studied using various techniques, such as transmission electron microscopy, Fourier transformed infrared spectroscopy, N2 adsorption-desorption isotherms, and zeta potentials. The drug loading and release profile as well as the in vitro cell cytotoxicity were detaily investigated...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28737923/cosilencing-intestinal-transglutaminase-2-and-interleukin-15-using-gelatin-based-nanoparticles-in-an-in-vitro-model-of-celiac-disease
#15
Husain Attarwala, Valerie Clausen, Prasoon Chaturvedi, Mansoor M Amiji
In this study, we have developed a type B gelatin nanoparticle based siRNA delivery system for silencing of intestinal transglutaminase-2 (TG2) and interleukin-15 (IL-15) genes in cultured human intestinal epithelial cells (Caco-2) and murine alveolar macrophage cells (J774A.1). Small interfering RNA (siRNA) targeting the TG2 or IL-15 gene was encapsulated within gelatin nanoparticles using ethanol-water solvent displacement method. Size, charge, and morphology of gelatin nanoparticles were evaluated using a Zetasizer instrument and transmission electron microscopy...
August 10, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28728978/anticancer-drug-loaded-quantum-dots-engineered-polymeric-nanoparticles-diagnosis-therapy-combined-approach
#16
D Belletti, G Riva, M Luppi, G Tosi, F Forni, M A Vandelli, B Ruozi, F Pederzoli
Primary Effusion Lymphoma (PEL) is an HHV-8-related non Hodgkin lymphoma localized in body cavities (as pleural, peritoneal and pericardial) presenting lymphomatous effusion that, until now, lack of an effective therapy. Curcumin was reported to display pro-apoptotic effect via the inhibition of the JAK/STAT pathway, that is overexpressed in PEL cells, as consequence of virus infection. The administration of curcumin is severely restricted by its physicochemical properties, mainly its low solubility in biological fluid and consequently low bioavailability...
July 18, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28723064/doxorubicin-intracellular-remote-release-from-biocompatible-oligo-ethylene-glycol-methyl-ether-methacrylate-based-magnetic-nanogels-triggered-by-magnetic-hyperthermia
#17
Esther Cazares-Cortes, Ana Espinosa, Jean-Michel Guigner, Aude Michel, Nébéwia Griffete, Claire Wilhelm, Christine Ménager
Hybrid nanogels, composed of thermoresponsive polymers and superparamagnetic nanoparticles, are attractive nanocarriers for biomedical applications, being able-as a polymer matrix-to uptake and release high quantities of chemotherapeutic agents and-as magnetic nanoparticles-to be heated when exposed to an alternative magnetic field (AMF), better known as magnetic hyperthermia. Herein, biocompatible, pH-responsive, magnetoresponsive, and thermoresponsive nanogels, based on oligo(ethylene glycol) methyl ether methacrylate monomers and a methacrylic acid comonomer were prepared by conventional precipitation radical copolymerization in water, post-assembled by complexation with iron oxide magnetic nanoparticles (MNPs) of maghemite (γ-Fe2O3), and loaded with an anticancer drug (doxorubicin, DOX), for remotely controlled drug release by a "hot spot", as an athermal magnetic hyperthermia strategy against cancer...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28715515/surgical-suture-releasing-macrophage-targeted-drug-loaded-nanoparticles-for-an-enhanced-anti-inflammatory-effect
#18
Hansol Kim, Byung Hwi Kim, Beom Kang Huh, Yeon Chun Yoo, Chan Yeong Heo, Young Bin Choy, Ji-Ho Park
A surgical suture is a medical device to close the wound site of skin and organs but excessive inflammation surrounding the suture can disrupt the wound healing process. Although post-operative prescription of anti-inflammatory drugs is used to manage the inflammation, the need for local drug delivery systems has been rising because of low bioavailability and fast clearance of drugs. In this work, we proposed a new strategy for a local anti-inflammatory device by incorporating macrophage-targeted anti-inflammatory nanoparticles into the suture...
July 25, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28713017/intracellular-co-delivery-of-sr-ion-and-phenamil-drug-through-mesoporous-bioglass-nanocarriers-synergizes-bmp-signaling-and-tissue-mineralization
#19
Jung-Hwan Lee, Nandin Mandakhbayar, Ahmed El-Fiqi, Hae-Won Kim
Inducing differentiation and maturation of resident multipotent stem cells (MSCs) is an important strategy to regenerate hard tissues in mal-calcification conditions. Here we explore a co-delivery approach of therapeutic molecules comprised of ion and drug through a mesoporous bioglass nanoparticle (MBN) for this purpose. Recently, MBN has offered unique potential as a nanocarrier for hard tissues, in terms of high mesoporosity, bone bioactivity (and possibly degradability), tunable delivery of biomolecules, and ionic modification...
July 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28712326/calcium-phosphate-nanoparticles-as-a-new-generation-vaccine-adjuvant
#20
Yahua Lin, Xin Wang, Xiaofen Huang, Jun Zhang, Ningshao Xia, Qinjian Zhao
Adjuvants are essential components in vaccine formulations to induce robust immunity against pathogens. The most widely used adjuvants in human vaccines are aluminum salts, that can effectively elicit a T helper type-2 (Th2)-biased humoral immune response for producing a high antibody titer but with a limited cellular immune response. Biocompatible calcium phosphate nanoparticles (CaP-NPs) with tunable characteristics have potentials to function as adjuvants for inducing more balanced T helper type-1 (Th1) and Th2 immune responses...
September 2017: Expert Review of Vaccines
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