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Post-loaded nanoparticle

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https://www.readbyqxmd.com/read/28605895/hydrogel-patches-on-live-cells-through-surface-mediated-polymerization
#1
Pei-Jung Wu, Jacob L Lilly, Roberto Arreaza, Brad J Berron
Many naturally-occurring cells possess an intrinsic ability to cross biological barriers that block conventional drug delivery, and these cells offer a possible mode of active transport across the blood brain barrier or into the core of tumor masses. While many technologies exist to form complete, nanoparticle loaded coatings on cells, a complete coating on the cell surface would disrupt the interaction of cells with their environments. To address this issue, cell surface patches that partially cover cell surfaces might provide a superior approach for cell mediated therapeutic delivery...
June 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28579777/electrohydrodynamic-fabrication-of-core-shell-plga-nanoparticles-with-controlled-release-of-cisplatin-for-enhanced-cancer-treatment
#2
Philip Jt Reardon, Maryam Parhizkar, Anthony H Harker, Richard J Browning, Vessela Vassileva, Eleanor Stride, R Barbara Pedley, Mohan Edirisinghe, Jonathan C Knowles
Increasing the clinical efficacy of toxic chemotherapy drugs such as cisplatin (CDDP), via targeted drug delivery, is a key area of research in cancer treatment. In this study, CDDP-loaded poly(lactic-co-glycolic acid) (PLGA) polymeric nanoparticles (NPs) were successfully prepared using electrohydrodynamic atomization (EHDA). The configuration was varied to control the distribution of CDDP within the particles, and high encapsulation efficiency (>70%) of the drug was achieved. NPs were produced with either a core-shell (CS) or a matrix (uniform) structure...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28575997/multimodal-nanoporous-silica-nanoparticles-functionalized-with-aminopropyl-groups-for-improving-loading-and-controlled-release-of-doxorubicin-hydrochloride
#3
Xin Wang, Chang Li, Na Fan, Jing Li, Zhonggui He, Jin Sun
The purpose of this study was to develop amino modified multimodal nanoporous silica nanoparticles (M-NSNs-NH2) loaded with doxorubicin hydrochloride (DOX), intended to enhance the drug loading capacity and to achieve controlled release effect. M-NSNs were functionalized with aminopropyl groups through post-synthesis. The contribution of large pore sizes and surface chemical groups on DOX loading and release were systemically studied using transmission electron microscope (TEM), nitrogen adsorption/desorption measurement, Fourier transform infrared spectroscopy (FTIR), zeta potential analysis, X-ray photoelectron spectroscopy (XPS) and ultraviolet spectrophotometer (UV)...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28535789/a-multi-target-therapeutic-potential-of-prunus-domestica-gum-stabilized-nanoparticles-exhibited-prospective-anticancer-antibacterial-urease-inhibition-anti-inflammatory-and-analgesic-properties
#4
Nazar Ul Islam, Raza Amin, Muhammad Shahid, Muhammad Amin, Sumera Zaib, Jamshed Iqbal
BACKGROUND: Phytotherapeutics exhibit diverse pharmacological effects that are based on the combined action of a mixture of phytoconstituents. In this study, Prunus domestica gum-loaded, stabilized gold and silver nanoparticles (Au/Ag-NPs) were evaluated for their prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory, and analgesic properties. METHODS: Au/Ag-NPs were biosynthesized and characterized with UV-Vis, FTIR, SEM, EDX, and XRD techniques...
May 23, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28528626/colloid-particle-formulations-for-antimicrobial-applications
#5
REVIEW
Ahmed F Halbus, Tommy S Horozov, Vesselin N Paunov
Colloidal particles are being extensively studied in various antimicrobial applications due to their small size to volume ratio and ability to exhibit a wide spectrum of antibacterial, antifungal, antialgal and antiviral action. The present review focuses on various nanoparticles (NPs) of inorganic, organic and hybrid materials, and discusses some of the methods for their preparation as well as mechanisms of their antimicrobial action. We consider the antimicrobial applications of metal oxide nanoparticles (ZnO, MgO, CuO, Cu2O, Al2O3, TiO2, CeO2 and Y2O3), metal nanoparticles (NPs), such as copper, silver and gold, metal hydroxide NPs such as Mg(OH)2 as well as hybrid NPs made from biodegradable materials, such as chitosan, lignin and dextran, loaded with other antimicrobial agents...
May 12, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28528300/treating-metastatic-triple-negative-breast-cancer-with-cd44-neuropilin-dual-molecular-targets-of-multifunctional-nanoparticles
#6
De-Sheng Liang, Wen-Jie Zhang, Ai-Ting Wang, Hai-Tao Su, Hai-Jun Zhong, Xian-Rong Qi
Metastasis of cancer makes up the vast majority of cancer-related deaths, and it usually initiates from tumor cells invasiveness and develops through tumor neovasculature. In this work, we have fabricated a CD44/neuropilin dual receptor-targeting nanoparticulate system (tLyP-1-HT NPs) with endogenous or FDA approved components for treating metastatic triple negative breast cancer (TNBC). The enhanced specific targeting of tLyP-1-HT NPs to both metastatic tumor cells and metastasis-supporting tumor neovasculature was contributed by means of CD44/neuropilin dual receptor-mediated interaction...
May 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/28499164/mechanical-properties-and-antibiotic-release-characteristics-of-poly-methyl-methacrylate-based-bone-cement-formulated-with-mesoporous-silica-nanoparticles
#7
Kumaran Letchmanan, Shou-Cang Shen, Wai Kiong Ng, Poddar Kingshuk, Zhilong Shi, Wilson Wang, Reginald B H Tan
The influence of mesoporous silica nanoparticles (MSNs) loaded with antibiotics on the mechanical properties of functional poly(methyl methacrylate)-(PMMA) based bone cements is investigated. The incorporation of MSNs to the bone cements (8.15wt%) shows no detrimental effects on the biomechanical properties of the freshly solidified bone cements. Importantly, there are no significant changes in the compression strength and bending modulus up to 6 months of aging in PBS buffer solution. The preserved mechanical properties of MSN-functionalized bone cements is attributed to the unchanged microstructures of the cements, as more than 96% of MSNs remains in the bone cement matrix to support the cement structures after 6 months of aging...
May 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28494265/intramyocardial-fate-and-effect-of-iron-nanoparticles-co-injected-with-macs-%C3%A2-purified-stem-cell-products
#8
Paula Müller, Ralf Gaebel, Heiko Lemcke, Frank Wiekhorst, Frauke Hausburg, Cajetan Lang, Nicole Zarniko, Bernd Westphal, Gustav Steinhoff, Robert David
BACKGROUND: Magnetic activated cell sorting (MACS(®)) is routinely used to isolate stem cell subpopulations intended for the treatment of cardiovascular diseases. In strong contrast, studies examining the amount, effect and intramyocardial distribution of iron nanoparticles used for magnetic cell labelling are missing, although iron excess can cause functional disorders in the heart. METHODS AND RESULTS: CD133(+) haematopoietic and CD271(+) mesenchymal stem cells were purified from bone marrow using automatically and manually MACS(®) based systems...
May 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28489093/mgal-layered-double-hydroxide-chitosan-porous-scaffolds-loaded-with-pft%C3%AE-to-promote-bone-regeneration
#9
Yi-Xuan Chen, Rong Zhu, Qin-Fei Ke, You-Shui Gao, Chang-Qing Zhang, Ya-Ping Guo
Poor bone formation remains a key risk factor associated with acellular scaffolds that occurs in some bone defects, particularly in patients with metabolic bone disorders and local osteoporosis. We herein fabricated for the first time layered double hydroxide-chitosan porous scaffolds loaded with PFTα (LDH-CS-PFTα scaffolds) as therapeutic bone scaffolds for the controlled release of PFTα to enhance stem cell osteogenic differentiation and bone regeneration. The LDH-CS scaffolds had three-dimensional interconnected macropores, and plate-like LDH nanoparticles were uniformly dispersed within or on the CS films...
May 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28479864/chemisorption-of-iodine-125-to-gold-nanoparticles-allows-for-real-time-quantitation-and-potential-use-in-nanomedicine
#10
Adrian A Walsh
Gold nanoparticles have been available for many years as a research tool in the life sciences due to their electron density and optical properties. New applications are continually being developed, particularly in nanomedicine. One drawback is the need for an easy, real-time quantitation method for gold nanoparticles so that the effects observed in in vitro cell toxicity assays and cell uptake studies can be interpreted quantitatively in terms of nanoparticle loading. One potential method of quantifying gold nanoparticles in real time is by chemisorption of iodine-125, a gamma emitter, to the nanoparticles...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28479343/oral-dna-vaccines-based-on-cs-tpp-nanoparticles-and-alginate-microparticles-confer-high-protection-against-infectious-pancreatic-necrosis-virus-ipnv-infection-in-trout
#11
Sohrab Ahmadivand, Mehdi Soltani, Mahdi Behdani, Øystein Evensen, Ehsan Alirahimi, Reza Hassanzadeh, Ellahe Soltani
Infectious pancreatic necrosis virus (IPNV) is the etiological agent of a contagious viral disease causing remarkable mortalities in different fish species. Despite the availability of commercial vaccines against IPN, the disease still constitutes one of the main threats to the aquaculture industry worldwide. In this study, we developed a DNA vaccine encoding the VP2 gene of IPNV and evaluated its ability to induce protective immunity in rainbow trout fry (3 g) at doses of 10 and 25 μg/fish and boosting with the same doses two weeks later through the oral route using chitosan/tripolyphosphate (CS-TPP) nanoparticles and alginate microparticles incorporated into fish feed...
May 4, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28476616/preparation-of-liposomes-containing-small-gold-nanoparticles-using-electrostatic-interactions
#12
Gennaro A Dichello, Takahiro Fukuda, Toru Maekawa, Raymond L D Whitby, Sergey V Mikhalovsky, Mohammed Alavijeh, Ananth S Pannala, Dipak K Sarker
The development of liposome-nanoparticle colloid systems offers a versatile approach towards the manufacture of multifunctional therapeutic platforms. A strategy to encapsulate small metallic nanoparticles (<4nm) within multilamellar vesicles, effected by exploiting electrostatic interactions was investigated. Two liposome-gold nanoparticle (lipo-GNP) systems were prepared by the reverse-phase evaporation method employing cationic or anionic surface functionalised particles in combination with oppositely charged lipid compositions with subsequent post-formulation PEGylation...
May 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28423949/intranasal-chitosan-g-hp%C3%AE-cd-nanoparticles-of-efavirenz-for-the-cns-targeting
#13
Aarti Belgamwar, Shagufta Khan, Pramod Yeole
Incompetence of antiretrovirals (ARV) in complete eradication of HIV from the CNS is the biggest issue in neuro-AIDS treatment. The ineffectiveness is largely due to the poor penetration of ARV. Hence, the present study is attempted to enhance the CNS uptake of efavirenz (EFV) by designing intranasal EFV nanoparticles (EFV-NPs). EFV-NPs were fabricated using chitosan-g-HPβCD by ionic gelation method and optimized using quadratic response surface methodology (RSM) employing two-factor, five-level circumscribed central composite design...
April 19, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28350437/bacteria-activated-theranostic-nanoprobes-against-methicillin-resistant-staphylococcus-aureus-infection
#14
Zhiwei Zhao, Rong Yan, Xuan Yi, Jingling Li, Jiaming Rao, Zhengqing Guo, Yanmei Yang, Weifeng Li, Yong-Qiang Li, Chunying Chen
Despite numerous advanced imaging and sterilization techniques available nowadays, the sensitive in vivo diagnosis and complete elimination of drug-resistant bacterial infections remain big challenges. Here we report a strategy to design activatable theranostic nanoprobes against methicillin-resistant Staphylococcus aureus (MRSA) infections. This probe is based on silica nanoparticles coated with vancomycin-modified polyelectrolyte-cypate complexes (SiO2-Cy-Van), which is activated by an interesting phenomenon of bacteria-responsive dissociation of the polyelectrolyte from silica nanoparticles...
March 30, 2017: ACS Nano
https://www.readbyqxmd.com/read/28302707/neuropeptide-y3-36-incorporated-into-pvax-nanoparticle-improves-functional-blood-flow-in-a-murine-model-of-hind-limb-ischemia
#15
Derek Eshun, Rabya Saraf, Soochan Bae, Jelliffe Jeganathan, Feroze Mahmood, Serkan Dilmen, Qingen Ke, Dongwon Lee, Peter M Kang, Robina Matyal
We generated a novel nanoparticle called PVAX, which has intrinsic anti-apoptotic and anti-inflammatory properties. This nanoparticle was loaded with Neuropeptide Y3-36, an angiogenic neuro-hormone that plays a central role in angiogenesis. Subsequently, we investigated whether PVAX-NPY3-36 could act as a therapeutic agent and induce angiogenesis and vascular remodeling in a murine model of hind limb ischemia. Adult C57BL/J6 mice (n=40) were assigned to treatment groups: Control, Ischemia PBS, Ischemia PVAX, Ischemia NPY3-36, and Ischemia PVAX-NPY3-36 Ischemia was induced by ligation of the femoral artery in all groups except Control and given relevant treatments (PBS, PVAX, NPY3-36, and PVAX-NPY3-36)...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28276166/high-areal-capacity-si-licoo2-batteries-from-electrospun-composite-fiber-mats
#16
Ethan C Self, Michael Naguib, Rose E Ruther, Emily C McRen, Ryszard Wycisk, Gao Liu, Jagjit Nanda, Peter N Pintauro
Freestanding nanofiber mat Li-ion battery anodes containing Si nanoparticles, carbon black, and poly(acrylic acid) (Si/C/PAA) are prepared using electrospinning. The mats are compacted to a high fiber volume fraction (≈0.85), and interfiber contacts are welded by exposing the mat to methanol vapor. A compacted+welded fiber mat anode containing 40 wt % Si exhibits high capacities of 1484 mA h g(-1) (3500 mA h g-1Si ) at 0.1 C and 489 mA h g(-1) at 1 C and good cycling stability (e...
April 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28247754/small-sized-mpeg-plga-nanoparticles-of-schisantherin-a-with-sustained-release-for-enhanced-brain-uptake-and-anti-parkinsonian-activity
#17
Tongkai Chen, Chuwen Li, Ye Li, Xiang Yi, Ruibing Wang, Simon Ming-Yuen Lee, Ying Zheng
Schisantherin A (SA) is a promising anti-Parkinsonism natural product. However, its poor water solubility and rapid serum clearance impose significant barriers to delivery of SA to the brain. This work aimed to develop SA in a nanoparticle formulation that extended SA circulation in the bloodstream and consequently an increased brain uptake and thus to be potentially efficacious for the treatment of Parkinson's disease (PD). Spherical SA nanoparticles with a mean particle size of 70 nm were prepared by encapsulating SA into methoxy poly(ethylene glycol)-block-poly(d,l)-lactic-co-glycolic acid (mPEG-PLGA) nanoparticles (SA-NPs) with an encapsulation efficiency of ∼91% and drug loading of ∼28%...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28213304/photocatalytic-effects-of-titanium-dioxide-nanoparticles-on-aquatic-organisms-current-knowledge-and-suggestions-for-future-research
#18
REVIEW
Vena N Haynes, J Evan Ward, Brandon J Russell, Alexander G Agrios
Nanoparticles are entering natural systems through product usage, industrial waste and post-consumer material degradation. As the production of nanoparticles is expected to increase in the next decade, so too are predicted environmental loads. Engineered metal-oxide nanomaterials, such as titanium dioxide, are known for their photocatalytic capabilities. When these nanoparticles are exposed to ultraviolet radiation in the environment, however, they can produce radicals that are harmful to aquatic organisms...
April 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28161429/mzd7349-peptide-conjugated-plga-nanoparticles-directed-against-vcam-1-for-targeted-delivery-of-simvastatin-to-restore-dysfunctional-huvecs
#19
Fatemeh Imanparast, Mohammad Ali Faramarzi, Akram Vatannejad, Maliheh Paknejad, Behnas Deiham, Farzad Kobarfard, Amir Amani, Mahmood Doosti
Endothelial dysfunction is initial and critical step of atherosclerosis. Impaired bioavailability of endothelial nitric oxide synthase (eNOS) is one of the main reasons of endothelial dysfunction. Improving bioavailability of eNOS by increasing its expression or activity using statins is an effective therapeutic strategy in restoring endothelial dysfunction. In this study, simvastatin (SIM) as a poorly water-soluble drug was loaded in poly (lactic-co-glycolic acid) (PLGA) nanoparticles (SIM-PLGA-NPs). NPs were then conjugated with mZD7349 peptide (mZD7349-SIM-PLGA-NPs) and directed against vascular cell adhesion molecule 1 (VCAM-1)...
February 2, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28156084/bone-marrow-derived-mesenchymal-stem-cell-loaded-fibrin-patches-act-as-a-reservoir-of-paracrine-factors-in-chronic-myocardial-infarction
#20
Eléonore Blondiaux, Laetitia Pidial, Gwennhael Autret, Gabriel Rahmi, Daniel Balvay, Etienne Audureau, Claire Wilhelm, Coralie L Guerin, Patrick Bruneval, Jean-Sébastien Silvestre, Philippe Menasché, Olivier Clément
The combination of mesenchymal stem cells and tissue-engineered fibrin patches improves the therapeutic efficacy of stem cells. In vivo cardiac magnetic resonance (4.7 Tesla) and ex vivo high-spatial resolution CMR were used to track the fate of human bone marrow-derived mesenchymal stem cell (BMSC) delivered on an epicardial scaffold and more specifically assess their potential intramyocardial migration. Fifty-seven nude rats underwent permanent coronary artery ligation. Two months later, those with a left ventricular ejection fraction ≤55% were randomly allocated to receive a patch loaded with human BMSC (BMSC-P, n = 10), a patch loaded with BMSCs labelled with iron oxide nanoparticles (BMSC*-P, n = 12), an acellular patch (A-P, n = 8) or to serve as sham-operated animals (SHAM, n = 7)...
February 3, 2017: Journal of Tissue Engineering and Regenerative Medicine
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