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Breast cancer in young women

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https://www.readbyqxmd.com/read/28108994/magnetic-resonance-imaging-directed-ultrasound-imaging-of-non-mass-enhancement-in-the-breast-outcomes-and-frequency-of-malignancy
#1
Adrienne R Newburg, Chloe M Chhor, Leng Leng Young Lin, Samantha L Heller, Jennifer Gillman, Hildegard K Toth, Linda Moy
OBJECTIVES: This study was performed to determine the frequency, predictors, and outcomes of ultrasound (US) correlates for non-mass enhancement. METHODS: From January 2005 to December 2011, a retrospective review of 5837 consecutive breast magnetic resonance imaging examinations at our institution identified 918 non-mass enhancing lesions for which follow-up or biopsy was recommended. Retrospective review of the images identified 879 of 918 lesions (96%) meeting criteria for non-mass enhancement...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28102529/recovery-from-chemotherapy-induced-white-matter-changes-in-young-breast-cancer-survivors
#2
Thibo Billiet, Louise Emsell, Mathieu Vandenbulcke, Ronald Peeters, Daan Christiaens, Alexander Leemans, Wim Van Hecke, Ann Smeets, Frederic Amant, Stefan Sunaert, Sabine Deprez
In a previous longitudinal diffusion tensor imaging (DTI) study, we observed cerebral white matter (WM) alterations (reduced fractional anisotropy (FA)) related to decreased cognitive performance 3-5 months after chemotherapy-treatment (t2) when compared to baseline (t1) (Deprez et al. in Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 30(3), 274-281. doi:10.1200/JCO.2011.36.8571, 2012). The current study investigates the evolution and the nature of these previously observed microstructural changes...
January 19, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28101229/retrospective-analysis-of-breast-cancer-prognosis-among-young-and-older-women-in-a-brazilian-cohort-of-738-patients-1985-2002
#3
Fabiana De Lima Vazquez, Thiago Buosi Silva, René Aloísio Da Costa Vieira, Allini Mafra Da Costa, Cristovam Scapulatempo, José Humberto Tavares Guerreiro Fregnani, Edmundo Carvalho Mauad, Adhemar Longatto, Kari Juhani Syrjänen
Invasive breast cancer (BC) is infrequent among women aged ≤40 years, however, the disease outlook in these younger patients is generally worse than among older women. The present study aimed to compare socio-demographic, clinical and pathological characteristics, and their association with long-term survival, between two random cohorts of young (≤40 years) and older (50-69 years) Brazilian patients with BC. The cohort comprised of 738 randomly selected women who were diagnosed with BC at Barretos Cancer Hospital, Pio XII Foundation (Barretos, Brazil) between January 1985 and December 2002; the patients included young women (n=376) and older women (n=362)...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28093034/fear-of-cancer-recurrence-and-unmet-needs-among-breast-cancer-survivors-in-the-first-five-years-a-cross-sectional-study
#4
Mai-Britt Bjørklund Ellegaard, Cai Grau, Robert Zachariae, Anders Bonde Jensen
BACKGROUND: It is unclear to which degree the services available after end of treatment are sufficient to meet the needs of women treated for breast cancer. The aim of the present study was to identify patient-reported supportive care needs and the prevalence of fear of cancer recurrence (FCR) following end of treatment in women treated for breast cancer. MATERIAL AND METHODS: Using a cross-sectional design, women treated for breast cancer (n = 155; mean age 63) completed questionnaires concerning supportive care needs and FCR...
January 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28077836/-decision-making-experience-on-breast-reconstruction-for-women-with-breast-cancer
#5
Myungsun Yi, Woo Joung Joung, Eun Young Park, Eun Jin Kwon, Haejin Kim, Ji Young Seo
PURPOSE: The purpose of this study was to explore decision making experiences of Korean women with breast cancer who underwent breast reconstruction with/after a mastectomy. METHODS: Data were collected during 2015-2016 through individual in-depth interviews with 10 women who had both mastectomy and breast reconstruction, and analyzed using phenomenological method to identify essential themes on experiences of making a decision to have breast reconstruction. RESULTS: Five theme clusters emerged...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28073726/breast-cancer-in-women-younger-than-35%C3%A2-years%C3%A2-features-and-outcomes-in-the-breast-unit-at-aristide-le-dantec-teaching-hospital-dakar
#6
M Gueye, S M Kane Gueye, M D Ndiaye Gueye, F Niasse Dia, O Gassama, M Diallo, J C Moreau
The aim of this study was to determine the clinical features and outcomes of women younger than 35 years with breast cancer. This study was performed at Gynecologic and Obstetric Clinic of Dakar Teaching Hospital and retrospectively reviewed the records of all women younger than 35 years seen in our department for histologically proven breast cancer. Data were analyzed with SPSS software (Statistical Package for Social Science) Version 23. Between 2007 and 2015, 62 women with breast cancer met the inclusion criteria and were included...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28070828/hypofractionated-stereotactic-radiosurgery-for-pituitary-metastases
#7
Haemin Chon, KyoungJun Yoon, Do Hoon Kwon, Chang Jin Kim, Min-Seon Kim, Young Hyun Cho
Pituitary metastases (PMs) are uncommon, representing only 1% of pituitary lesions. The diagnosis of PMs can be challenging and an optimal management remains to be determined. Here, we present a pilot clinical study on the efficacy and safety of hypofractionated stereotactic radiosurgery (SRS) with an optimized dosimetric plan in treating PMs. Between June 2013 and December 2014, seven consecutive patients (4 men and 3 women; median age 62 years) had been diagnosed with PMs based on their characteristic clinical and radiological features and subsequently treated using hypofractionated SRS...
January 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28065398/molecular-subtypes-and-prognosis-in-young-mexican-women-with-breast-cancer
#8
Cynthia Villarreal-Garza, Alejandro Mohar, Juan Enrique Bargallo-Rocha, Federico Lasa-Gonsebatt, Nancy Reynoso-Noverón, Juan Matus-Santos, Paula Cabrera, Claudia Arce-Salinas, Fernando Lara-Medina, Alberto Alvarado-Miranda, María Teresa Ramírez-Ugalde, Enrique Soto-Perez-de-Celis
INTRODUCTION: Young age represents an adverse prognostic factor in breast cancer (BC), and young women present with more advanced and aggressive disease. In Latin America, BC is increasing in young women, and there is a lack of information regarding the characteristics and outcomes of this patient population. PATIENTS AND METHODS: We retrospectively analyzed a database of 4315 women treated for BC at a single institution. We compared clinical characteristics, treatment, and survival between women ≤ 40 and > 40 years of age...
November 23, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28062981/body-size-from-birth-through-adolescence-in-relation-to-risk-of-benign-breast-disease-in-young-women
#9
Catherine S Berkey, Bernard Rosner, Rulla M Tamimi, Walter C Willett, Martha Hickey, Adetunji Toriola, A Lindsay Frazier, Graham A Colditz
PURPOSE: Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk. METHODS: The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28062399/longitudinal-study-of-mammographic-density-measures-that-predict-breast-cancer-risk
#10
Kavitha Krishnan, Laura Baglietto, Jennifer Stone, Julie A Simpson, Gianluca Severi, Christopher Evans, Robert J MacInnis, Graham G Giles, Carmel Apicella, John L Hopper
BACKGROUND: After adjusting for age and body mass index (BMI), mammographic measures - dense area (DA), percent dense area (PDA) and non-dense area (NDA) - are associated with breast cancer risk. Our aim was to use longitudinal data to estimate the extent to which these risk-predicting measures track over time. METHODS: We collected 4,320 mammograms (age range, 24-83 years) from 970 women in the Melbourne Collaborative Cohort Study and the Australian Breast Cancer Family Registry...
January 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28054348/the-effect-of-surgery-type-on-survival-and-recurrence-in-very-young-women-with-breast-cancer
#11
May Lynn Quan, Lawrence Frank Paszat, Kimberly A Fernandes, Rinku Sutradhar, David R McCready, Eileen Rakovitch, Ellen Warner, Frances C Wright, Nicole Hodgson, Muriel Brackstone, Nancy N Baxter
BACKGROUND: The impact of surgical treatment on outcomes in breast cacner in very young women remains unclear. We sought to determine the effect of surgery type on risk of recurrence and survival in a population-based cohort. METHODS: All women diagnosed with breast cancer aged ≤35 (1994-2003) were identified from the Ontario Cancer Registry. Patient, tumor, and treatment variables, including primary surgery, recurrences, and death were abstracted from chart review...
January 5, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28046087/the-rise-in-mortality-from-breast-cancer-in-young-women-trend-analysis-in-brazil
#12
Sheila Cristina Rocha-Brischiliari, Rosana Rosseto de Oliveira, Luciano Andrade, Adriano Brischiliari, Angela Andreia França Gravena, Maria Dalva de Barros Carvalho, Sandra Marisa Pelloso
INTRODUCTION: Breast cancer is the most common cause of cancer death among women. OBJECTIVE: The objective of this study was to analyze time trends in overall mortality from breast cancer in Brazil, Brazilian regions and States. METHODS: This is an exploratory study, of the time series of deaths from breast cancer contained in the Mortality Information System (SIM), of women living in Brazil, Brazilian regions and States, from 1996 to 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28040934/development-of-array-piezoelectric-fingers-towards-in-vivo-breast-tumor-detection
#13
Xin Xu, Youngsoo Chung, Ari D Brooks, Wei-Heng Shih, Wan Y Shih
We have investigated the development of a handheld 4 × 1 piezoelectric finger (PEF) array breast tumor detector system towards in vivo patient testing, particularly, on how the duration of the DC applied voltage, the depression depth of the handheld unit, and breast density affect the PEF detection sensitivity on 40 patients. The tests were blinded and carried out in four phases: with DC voltage durations 5, 3, 2, to 0.8 s corresponding to scanning a quadrant, a half, a whole breast, and both breasts within 30 min, respectively...
December 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28039656/novel-and-reported-pathogenic-variants-in-exon-11-of-brca2-gene-in-a-cohort-of-sri-lankan-young-breast-cancer-patients
#14
Sumadee De Silva, Kamani Hemamala Tennekoon, Aravinda Dissanayake, Kanishka De Silva, Lakshika Jayasekara
Women with breast carcinoma diagnosed before 40 years of age with a strong familial risk have a greater prevalence of germline BRCA1 or BRCA2 variants than late onset breast cancer. Previously germline variants in BRCA1 and BRCA2 genes were characterized in a cohort of Sri Lankan breast cancer patients unselected for age of onset. This study focused on young breast cancer patients who were screened for previously identified hotspot regions in BRCA2 gene. A total of 48 young breast cancer patients with family history of cancer and 25 healthy controls were studied...
December 30, 2016: Familial Cancer
https://www.readbyqxmd.com/read/28039569/young-adult-cancer-survivors-follow-up-care-expectations-of-oncologists-and-primary-care-physicians
#15
Kiara Hugh-Yeun, Divjot Kumar, Ali Moghaddamjou, Jenny Y Ruan, Winson Y Cheung
PURPOSE: Young adult cancer survivors face unique challenges associated with their illness. While both oncologists and primary care physicians (PCPs) may be involved in the follow-up care of these cancer survivors, we hypothesized that there is a lack of clarity regarding each physician's roles and responsibilities. METHODS: A self-administered survey was mailed to young adult cancer survivors in British Columbia, Canada, who were aged 20 to 39 years at the time of diagnosis and alive at 2 to 5 years following the diagnosis to capture their expectations of oncologists and PCPs in various important domains of cancer survivorship care...
December 30, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28031315/pooled-analysis-of-active-cigarette-smoking-and-invasive-breast-cancer-risk-in-14-cohort-studies
#16
Mia M Gaudet, Brian D Carter, Louise A Brinton, Roni T Falk, Inger T Gram, Juhua Luo, Roger L Milne, Sarah J Nyante, Elisabete Weiderpass, Laura E Beane Freeman, Dale P Sandler, Kim Robien, Kristin E Anderson, Graham G Giles, Wendy Y Chen, Diane Feskanich, Tonje Braaten, Claudine Isaacs, Lesley M Butler, Woon-Puay Koh, Alicja Wolk, Hans-Olov Adami, Emily White, Karen L Margolis, Michael J Thun, Susan M Gapstur
BACKGROUND: The 2014 US Surgeon General's report noted research gaps necessary to determine a causal relationship between active cigarette smoking and invasive breast cancer risk, including the role of alcohol consumption, timing of exposure, modification by menopausal status and heterogeneity by oestrogen receptor (ER) status. METHODS: To address these issues, we pooled data from 14 cohort studies contributing 934 681 participants (36 060 invasive breast cancer cases)...
December 28, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28013536/clinical-histopathological-and-molecular-characteristics-of-metastatic-breast-cancer-in-north-eastern-kazakhstan-a-10-year-retrospective-study
#17
Aizhan Abiltayeva, Malcolm Anthony Moore, Ayan Myssayev, Tasbolat Adylkhanov, Ainur Baissalbayeva, Kuantkan Zhabagin, Eldar Beysebayev
Background: Breast cancer (BC) is the top cancer among women worldwide and has been the most frequent malignancy among Kazakhstan women over the past few decades. Information on clinical and histopathological features of metastatic breast cancer (MBC), as well as the distribution of molecular subtypes is limited for Kazakh people. Materials and Methods: The present observational retrospective study was carried out at Regional Oncologic Dispensaries in the North-East Region of Kazakhstan (in Semey and Pavlodar cities)...
1, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28006769/is-menstruation-or-the-serum-hormone-level-a-useful-predictor-for-live-birth-after-gonadotropin-releasing-hormone-agonist-during-chemotherapy-in-young-breast-cancer-patients
#18
Dong-Yun Lee, DooSeok Choi
AIMS: The study aimed to investigate whether changes in menstruation or hormone levels are useful parameters to assess the efficacy of gonadotropin-releasing hormone (GnRH) agonist co-treatment with chemotherapy. METHODS: This study included women in their reproductive age diagnosed with breast cancer and who received GnRH agonist during chemotherapy for ovarian protection. Women with treatment failure (follicle-stimulating hormone (FSH) level >20 mIU/mL after at least 12 months and failure for becoming pregnant; n = 16) or with treatment success (becoming pregnant spontaneously and having a live birth; n = 20) were selected, and clinical characteristics, resumption of menstruation, and changes in hormone profiles were compared...
December 23, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27981168/the-experiences-and-perceptions-of-women-diagnosed-with-breast-cancer-during-pregnancy
#19
Sophie Rees, Annie Young
OBJECTIVE: Although much has been documented about the experience of breast cancer, the accounts of young women have been relatively neglected, despite that around 20% of the breast cancer diagnoses occur in women under the age of 50. In particular, the voices of young women diagnosed during pregnancy are missing from research. Breast cancer is the most common cancer associated with pregnancy, and it is diagnosed in about 1 in 3000 pregnancies. METHODS: This study presents data from three women drawn from a larger study of women who had been diagnosed under the age of 45 and had completed their treatment for breast cancer...
July 2016: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27977584/impact-of-lifestyle-and-psychological-stress-on-the-development-of-early-onset-breast-cancer
#20
Ping Li, Jialing Huang, Huina Wu, Cuixia Fu, Yun Li, Jiajia Qiu
The present study aimed to investigate risk factors for early onset breast cancer that are related to lifestyle and psychological stress. A comparative case-control study was performed among patients from the Department of Breast Surgery in Shanghai Cancer Center of Fudan University. The information regarding risk factors associated with the development of early onset breast cancer was collected using a questionnaire in a face-to-face interview. The distribution of the risk factors associated with the development of early onset breast cancer between the patient group and the control group was analyzed with logistic regression...
December 2016: Medicine (Baltimore)
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