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Breast cancer in young women

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https://www.readbyqxmd.com/read/29141042/a-tissue-microrna-signature-that-predicts-the-prognosis-of-breast-cancer-in-young-women
#1
Ai Hironaka-Mitsuhashi, Juntaro Matsuzaki, Ryou-U Takahashi, Masayuki Yoshida, Yutaka Nezu, Yusuke Yamamoto, Sho Shiino, Takayuki Kinoshita, Toshikazu Ushijima, Nobuyoshi Hiraoka, Chikako Shimizu, Kenji Tamura, Takahiro Ochiya
Since breast cancers in young women are generally aggressive, young patients tend to be intensively treated with anti-cancer drugs. To optimize the strategy for treatment, particularly in young women, prognostic biomarkers are urgently required. The objective of this study was to identify a tissue microRNA (miRNA) signature that predicts prognosis in young breast cancer patients. Total RNA from 45 breast cancer patients aged <35 years was extracted from formalin-fixed paraffin-embedded (FFPE) tissues and analyzed using miRNA microarrays...
2017: PloS One
https://www.readbyqxmd.com/read/29140420/growth-trajectories-breast-size-and-breast-tissue-composition-in-a-british-pre-birth-cohort-of-young-women
#2
Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Martin O Leach, David J Hawkes, Isabel Dos-Santos-Silva
Mammographic % density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations between magnetic resonance imaging (MRI) breast-tissue composition at age 21 years and prospectively-collected measures of body size and composition from birth to early adulthood, and markers of puberty (all standardized), in a sample of 500 nulliparous women from a pre-birth cohort of children born in Avon, England, in 1991-1992 and followed up to 2011-2014...
November 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29139590/breast-density-in-screening-mammography-in-indian-population-is-it-different-from-western-population
#3
Tulika Singh, Niranjan Khandelwal, Veenu Singla, Dileep Kumar, Madhu Gupta, Gurpreet Singh, Amanjit Bal
Mammography is the only method presently considered appropriate for mass screening of breast cancer. However, higher breast density was strongly associated with lower mammographic sensitivity. Breast density is also identified as independent and strongest risk factors for breast cancer. Studies have shown women with high breast density have four to six times increased risk of breast cancer as compare to women with fatty breast. It varies between different age group it generally decreases with increasing age in postmenopausal women and it can be different in different ethnic groups and people from different geographical areas...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29139588/breast-cancer-in-young-women-aged-35-and-under-patterns-of-care-and-outcome
#4
Maria Passhak, Shlomit Strulov Shachar, Gil Bar-Sela, Georgeta Fried
No abstract text is available yet for this article.
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29139006/correction-to-usefulness-of-abbreviated-breast-mri-screening-for-women-with-a-history-of-breast-cancer-surgery
#5
Bo Hwa Choi, Nami Choi, Mi Young Kim, Jung-Hyun Yang, Young Bum Yoo, Hae Kyoung Jung
In the original publication of the article, the acknowledgment section was missed out inadvertently. The acknowledgement section is below.
November 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29138205/long-term-prognosis-of-young-breast-cancer-patients-%C3%A2-40-years-who-did-not-receive-adjuvant-systemic-treatment-protocol-for-the-paradigm-initiative-cohort-study
#6
Gwen Mhe Dackus, Natalie D Ter Hoeve, Mark Opdam, Willem Vreuls, Zsuzsanna Varga, Esther Koop, Stefan M Willems, Carolien Hm Van Deurzen, Emilie J Groen, Alicia Cordoba, Jos Bart, Antien L Mooyaart, Jan G van den Tweel, Vicky Zolota, Jelle Wesseling, Anna Sapino, Ewa Chmielik, Ales Ryska, Frederic Amant, Annegien Broeks, Ron Kerkhoven, Nikolas Stathonikos, Mitko Veta, Adri Voogd, Katarzyna Jozwiak, Michael Hauptmann, Marlous Hoogstraat, Marjanka K Schmidt, Gabe Sonke, Elsken van der Wall, Sabine Siesling, Paul J van Diest, Sabine C Linn
INTRODUCTION: Currently used tools for breast cancer prognostication and prediction may not adequately reflect a young patient's prognosis or likely treatment benefit because they were not adequately validated in young patients. Since breast cancers diagnosed at a young age are considered prognostically unfavourable, many treatment guidelines recommend adjuvant systemic treatment for all young patients. Patients cured by locoregional treatment alone are, therefore, overtreated. Lack of prognosticators for young breast cancer patients represents an unmet medical need and has led to the initiation of the PAtients with bReAst cancer DIaGnosed preMenopausally (PARADIGM) initiative...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29130623/body-fatness-at-a-young-age-body-fatness-gain-and-risk-of-breast-cancer-systematic-review-and-meta-analysis-of-cohort-studies
#7
REVIEW
K Hidayat, C-M Yang, B-M Shi
Higher body fatness in adulthood has been consistently associated with an increased risk of postmenopausal breast cancer, as well as a tendency towards a lower risk of premenopausal breast cancer. However, the association between body fatness at a young age (≤30 years), body fatness gain and the risk of breast cancer is less defined. PubMed and Web of Science databases were searched to identify relevant publications. Risk estimates with 95% confidence intervals from each study were transformed into a continuous variable for each 5 kg m(-2) increase in body mass index (BMI) and were pooled under a random-effects model...
November 12, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29124494/information-and-support-needs-of-young-women-regarding-breast-cancer-risk-and-genetic-testing-adapting-effective-interventions-for-a-novel-population
#8
Suzanne C O'Neill, Chalanda Evans, Rebekah J Hamilton, Beth N Peshkin, Claudine Isaacs, Sue Friedman, Kenneth P Tercyak
Young women from hereditary breast and ovarian cancer (HBOC) families face a unique set of challenges in managing their HBOC risk, where obtaining essential information to inform decision making is key. Previous work suggests that this need for specific health information also comes at a time of heightened distress and greater individuation from family. In this report, we describe our adaptation of a previously-studied behavioral intervention for this population, utilizing a systematic approach outlined by the Centers for Disease Control and Prevention...
November 9, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29124356/low-lifetime-risk-of-contralateral-breast-cancer-in-a-middle-income-asian-country-evidence-to-guide-post-treatment-surveillance
#9
M H See, N Bhoo-Pathy, S Jamaris, A Kiran, D G Evans, C H Yip, N A Taib
BACKGROUND: The rate of contralateral risk-reducing mastectomy (CRRM) is increasing in the West with controversial evidence of improved survival in early breast cancer patients. Although uptake of CRRM in Asia appears low, the trends may rise, and there is currently an urgent need to provide evidence for informed decision-making in clinical practice. This study aims to determine the risk of contralateral breast cancer (CBC) and its associated factors in an Asian setting. METHOD: A total of 2937 newly diagnosed patients with stage I and stage II breast cancer in University Malaya Medical Centre between Jan 1993 to Dec 2012 were included in the study...
November 9, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29121898/clinicopathologic-and-prognostic-features-of-breast-cancer-in-young-women-a-series-from-north-of-morocco
#10
Joaira Bakkach, Mohamed Mansouri, Touria Derkaoui, Ali Loudiyi, Mohamed Fihri, Samia Hassani, Amina Barakat, Naima Ghailani Nourouti, Mohcine Bennani Mechita
BACKGROUND: Literature data reported a higher frequency of breast cancer in young women (BCYW) in developing countries. BCYW is associated with delayed diagnosis, aggressive biology and poor prognosis. However, our knowledge of biological profile, treatment received and outcome of young patients is still limited in Morocco. We propose to analyze clinicopathologic, therapeutic and prognostic features of BCYW among a series of patients native and/or inhabitant of North of Morocco. METHODS: We carried out a retro-prospective study of 331 infiltrating breast cancer cases registered between January 2010 and December 2015...
November 9, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29119452/mental-health-loneliness-and-illness-perception-outcomes-in-quality-of-life-among-young-breast-cancer-patients-after-mastectomy-the-role-of-breast-reconstruction
#11
Ioanna Fanakidou, Sofia Zyga, Victoria Alikari, Maria Tsironi, John Stathoulis, Paraskevi Theofilou
PURPOSE: Το explore the relationship between mental health (depression, anxiety, and stress), loneliness, and illness perception with health-related quality of life (HRQoL) in young breast cancer patients, within a year after mastectomy, and to investigate the role of breast reconstruction. METHODS: Eighty-one women with stage II breast cancer-35 with breast reconstruction and 46 without breast reconstruction-completed the Missoula-VITAS Quality of Life Index-15, the Depression Anxiety Stress Scale 21, the UCLA Loneliness Scale, the Brief Illness Perception Questionnaire, and a questionnaire with demographic and medical information...
November 8, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29116469/brca1-deficiency-is-a-recurrent-event-in-early-onset-triple-negative-breast-cancer-a-comprehensive-analysis-of-germline-mutations-and-somatic-promoter-methylation
#12
Rafael Canfield Brianese, Kivvi Duarte de Mello Nakamura, Fernanda Gabriella Dos Santos Ramos de Almeida, Rodrigo Fernandes Ramalho, Bruna Durães de Figueiredo Barros, Elisa Napolitano E Ferreira, Maria Nirvana da Cruz Formiga, Victor Piana de Andrade, Vladmir Claudio Cordeiro de Lima, Dirce Maria Carraro
PURPOSE: BRCA1 germline mutation is closely associated with triple-negative breast cancer. BRCA deficiency leads to impaired DNA repair and tumor development, and understanding this deficiency, in both hereditary and sporadic scenarios, is of great clinical and biological interest. Here, we investigated germline or somatic events that might lead to BRCA1 impairment in triple-negative breast cancer. We also analyzed the clinical implications associated with BRCA deficiency. METHODS: Next-generation sequencing for the BRCA1/2 genes and multiplex ligation-dependent probe amplification (MLPA) for the BRCA1 gene were performed for mutation screening...
November 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29116468/young-age-at-first-pregnancy-does-protect-against-early-onset-breast-cancer-in-brca1-and-brca2-mutation-carriers
#13
D G Evans, E F Harkness, S Howel, E R Woodward, A Howell, F Lalloo
PURPOSE: Previous research assessing the impact of pregnancy and age at first pregnancy on breast cancer risk in BRCA1 and BRCA2 mutation carriers has produced conflicting results, with some studies showing an increased risk following early first pregnancy in contrast to the reduced risk in the general population of women. The present study addresses these inconsistencies. METHODS: Female BRCA1 and BRCA2 carriers from North West England were assessed for breast cancer incidence prior to 50 years of age comparing those with an early first full-term pregnancy (< 21 years) to those without a full-term pregnancy...
November 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29111259/cancer-incidence-and-mortality-among-young-adults-aged-20-39-years-worldwide-in-2012-a-population-based-study
#14
Miranda M Fidler, Sumit Gupta, Isabelle Soerjomataram, Jacques Ferlay, Eva Steliarova-Foucher, Freddie Bray
BACKGROUND: To date, the burden of cancer among young adults has rarely been studied in depth. Our aim was to describe the scale and profile of cancer incidence and mortality worldwide among 20-39 year-olds, highlighting major patterns by age, sex, development level, and geographical region. METHODS: We did a population-based study to quantify the burden of young adult cancers worldwide. We defined young adult cancers as those occurring between the ages of 20 and 39 years because these individuals will have passed puberty and adolescence, but not yet experienced the effects of hormonal decline, immune response deterioration, or organ dysfunction associated with chronic health conditions...
October 27, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29098528/safety-of-fertility-preservation-in-breast-cancer-patients-in-a-register-based-matched-cohort-study
#15
Kenny A Rodriguez-Wallberg, Sandra Eloranta, Kamilla Krawiec, Agneta Lissmats, Jonas Bergh, Annelie Liljegren
PURPOSE: To determine if women with breast cancer that undergo fertility preservation (FP), with or without hormonal stimulation, present with an increased risk of breast cancer recurrence. METHODS: A matched cohort study on women with breast cancer attempting to ensure FP in Stockholm from 1999 to 2013 [exposed women (n = 188), age-matched unexposed controls (n = 378)] was designed using the Stockholm regional data from the Swedish National Breast Cancer Quality Register...
November 2, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29078121/cancer-in-adolescents-and-young-adults-national-incidence-and-characteristics-in-japan
#16
Izumi Inoue, Fumiaki Nakamura, Kimikazu Matsumoto, Tetsuya Takimoto, Takahiro Higashi
OBJECTIVE: Adolescents and young adults (AYA) with cancer are confronted with unique challenges in areas of paramount concern within their age group, such as fertility, education, career, and delayed and long-term effects of treatment. However, the extent and depth of the problem has never been examined in the Japanese population. The aim of this study was to describe the status of cancer patients in the AYA population, using data from the hospital-based cancer registry (HBCR). STUDY DESIGN: Patients included in the HBCR from January 2011 to December 2014 were included in this study to evaluate the incidence and cancer distribution trends among AYA...
October 24, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29076314/the-usefulness-of-pedicled-perforator-flap-in-partial-breast-reconstruction-after-breast-conserving-surgery-in-korean-women
#17
Jae Bong Kim, Dong Kyu Kim, Jeong Woo Lee, Kang Young Choi, Ho Yun Chung, Byung Chae Cho, Ho Yong Park, Jee Yeon Lee, Jung Dug Yang
Background: The emergence of breast-conserving surgery combined with radiotherapy as the treatment of choice for early stage breast cancer has resulted in greater focus on oncoplastic breast surgery. The use of perforator flaps has particularly gained in reputation for its effectiveness in the reconstruction of partial breast defects in Korean women. Herein, we present our experience with the use of TDAP (thoracodorsal artery perforator) and LICAP (lateral intercostal artery perforator) flaps...
October 27, 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29072405/factors-associated-with-a-lack-of-knowledge-of-performing-breast-self-examination-and-unawareness-of-cervical-cancer-screening-services-evidence-from-the-2015-egypt-health-issues-survey
#18
Rami H. Al-Rifai, Tom Loney
Background: The incidence of breast and cervical cancers is growing rapidly among Egyptian women. In this context, we assessed the prevalence of, and factors associated with the lack of knowledge among Egyptian females of performing breast self–examination (BSE) and unawareness of cervical smear cancer screening services. Methods: Secondary data analysis was performed on a representative population-based sample of 7,518 Egyptian females aged 15–59 years from the 2015 Egypt Health Issues Survey (EHIS). Crude and adjusted odds ratios (aOR) were used to explore the relationship between sociodemographic variables and having a lack of knowledge of performing BSE or unaware of cervical smear cancer screening service amongst 6,572 and 6,942 Egyptian females aged 21–59 years, respectively...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29072066/breast-cancer-screening-disparity-among-korean-american-immigrant-women-in-midwest
#19
Hee Yun Lee, Mi Hwa Lee, Yoo Jeong Jang, Do Kyung Lee
Purpose: Using three breast cancer screening methods such as mammogram, Clinical Breast Examination (CBE), and Breast Self-Examination (BSE), this study investigated breast cancer screening rates and its associated factors in Korean American immigrant women. Method: Cross-sectional data were obtained from 168 Korean immigrant women aged 40 and older in Midwest. The Andersen’s Behavioral Model (1995) theoretically guided this study and logistic regression was used to examine factors associated with screening receipt and performance...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29056033/a-comparison-of-breast-cancer-survivals-among-young-middle-and-elderly-aged-patients-of-southern-iran-using-cox-and-empirical-bayesian-additive-hazard-models
#20
Samane Nematolahi, Seyyed Mohammad Tagh Ayatollahi
Objectives: Survival analysis of breast cancer patients in three age categories is rare in southern Iran. This paper aims at quantifying prognostic factors contributed to poor prognosis, using Cox and empirical Bayesian additive hazard (EBAH) models among Young (20-39 years), middle (40-64 years) and elderly aged ( over 65 years) women. Methods: Data related to a total of 1,574 breast cancer patients diagnosed from 2002 to 2012 in the cancer registry of Fars province (Southern Iran), stratified in the three age groups...
October 16, 2017: Epidemiology and Health
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