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https://www.readbyqxmd.com/read/28927348/creating-a-medical-education-enterprise-leveling-the-playing-fields-of-medical-education-vs-medical-science-research-within-core-missions
#1
Satid Thammasitboon, B Lee Ligon, Geeta Singhal, Gordon E Schutze, Teri L Turner
BACKGROUND: Unlike publications of medical science research that are more readily rewarded, clinician-educators' scholarly achievements are more nebulous and under-recognized. OBJECTIVE: Create an education enterprise that empowers clinician-educators to engage in a broad range of scholarly activities and produce educational scholarship using strategic approaches to level the playing fields within an organization. DESIGN: The authors analyzed the advantages and disadvantages experienced by medical science researchers vs...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28925866/autophagy-as-a-molecular-target-of-flavonoids-underlying-their-protective-effects-in-human-disease
#2
Néstor Prieto-Domínguez, María V García-Mediavilla, Sonia Sánchez Campos, José Luis Mauriz, Javier González-Gallego
Autophagy is a cellular pathway with the ability to maintain cell homeostasis through the elimination of damaged or useless cellular components. Nevertheless, its prolonged activation may lead to programmed cell death. The autophagy process is characterized by the formation of a double-membranous vesicle that engulfs a cytoplasm portion and, subsequently, fuses with a lysosome where swallowed components are broken down and come back to the cytosol to be recycled. This pathway is crucial in the normal running of the whole corporal organs and tissues; thus, its deregulation may initiate or aggravate some human diseases...
September 18, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28925292/using-a-media-campaign-to-increase-engagement-with-a-mobile-based-youth-smoking-cessation-program
#3
Amy Sanders, Cendrine Robinson, Shani C Taylor, Samantha D Post, Jeffrey Goldfarb, Rui Shi, Yvonne M Hunt, Erik M Augustson
PURPOSE: To describe the impact of the National Cancer Institute's promotion of its youth smoking cessation program, Smokefree Teen (SFT). DESIGN: We provide a description of campaign strategies and outcomes as a means to engage a teen audience in cessation resources using a cost-effective approach. SETTING: The campaign occurred nationally, using traditional (TV and radio), online, and social media outreach. PARTICIPANTS: Ads targeted adolescent smokers (aged 14-17)...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28924687/comskil-communication-training-in-oncology-adaptation-to-german-cancer-care-settings
#4
Tim J Hartung, David Kissane, Anja Mehnert
Medical communication is a skill which can be learned and taught and which can substantially improve treatment outcomes, especially if patients' communication preferences are taken into account. Here, we give an overview of communication training research and outline the COMSKIL program as a state-of-the-art communication skills training in oncology. COMSKIL has a solid theoretical foundation and teaches core elements of medical communication in up to ten fully operationalized modules. These address typical situations ranging from breaking bad news to responding to difficult emotions, shared decision-making, and communicating via interpreters...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28919944/network-analysis-on-attitudes-a-brief-tutorial
#5
Jonas Dalege, Denny Borsboom, Frenk van Harreveld, Han L J van der Maas
In this article, we provide a brief tutorial on the estimation, analysis, and simulation on attitude networks using the programming language R. We first discuss what a network is and subsequently show how one can estimate a regularized network on typical attitude data. For this, we use open-access data on the attitudes toward Barack Obama during the 2012 American presidential election. Second, we show how one can calculate standard network measures such as community structure, centrality, and connectivity on this estimated attitude network...
July 2017: Social Psychological and Personality Science
https://www.readbyqxmd.com/read/28919018/de-novo-transcriptome-assembly-of-the-calanoid-copepod-neocalanus-flemingeri-a-new-resource-for-emergence-from-diapause
#6
Vittoria Roncalli, Matthew C Cieslak, Stephanie A Sommer, Russell R Hopcroft, Petra H Lenz
Copepods, small planktonic crustaceans, are key links between primary producers and upper trophic levels, including many economically important fishes. In the subarctic North Pacific, the life cycle of copepods like Neocalanus flemingeri includes an ontogenetic migration to depth followed by a period of diapause (a type of dormancy) characterized by arrested development and low metabolic activity. The end of diapause is marked by the production of the first brood of eggs. Recent temperature anomalies in the North Pacific have raised concerns about potential negative effects on N...
September 14, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28912793/diverse-rice-landraces-of-north-east-india-enables-the-identification-of-novel-genetic-resources-for-magnaporthe-resistance
#7
Bangale Umakanth, Balija Vishalakshi, P Sathish Kumar, S J S Rama Devi, Vijay Pal Bhadana, P Senguttuvel, Sudhir Kumar, Susheel Kumar Sharma, Pawan Kumar Sharma, M S Prasad, Maganti S Madhav
North-East (NE) India, the probable origin of rice has diverse genetic resources. Many rice landraces of NE India were not yet characterized for blast resistance. A set of 232 landraces of NE India, were screened for field resistance at two different hotspots of rice blast, viz., IIRR-UBN, Hyderabad and ICAR-NEH, Manipur in two consecutive seasons. The phenotypic evaluation as well as gene profiling for 12 major blast resistance genes (Pitp, Pi33, Pi54, Pib, Pi20, Pi38, Pita2, Pi1, Piz, Pi9, Pizt, and Pi40) with linked as well as gene-specific markers, identified 84 resistant landraces possessing different gene(s) either in singly or in combinations and also identified seven resistant landraces which do not have the tested genes, indicating the valuable genetic resources for blast resistance...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28904791/brucellosis-in-livestock-and-wildlife-zoonotic-diseases-without-pandemic-potential-in-need-of-innovative-one-health-approaches
#8
Jacques Godfroid
Human brucellosis remains the commonest zoonotic disease worldwide with more than 500 000 new cases annually. Understanding the biology of Brucella infections and the transmission patterns at the wildlife/livestock/human interface is of paramount importance before implementing any brucellosis control or eradication program in animals, even more so should interventions be justified within One Health. In addition to calling for transdisciplinary collaboration, One Health formally aims to conserve the environment and to promote the well-being of animals...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28904547/the-process-of-transition-to-hemodialysis-a-grounded-theory-research
#9
Parkhideh Hassani, Masoumeh Otaghi, Mansoureh Zagheri-Tafreshi, Alireza Nikbakht-Nasrabadi
BACKGROUND: Transition is a passage or movement from one state, condition, or place to another. Patients with chronic disorders such as end-stage renal disease experience transitions. This study aims to explore the process of transition to hemodialysis. MATERIALS AND METHODS: This is a qualitative grounded theory of a doctoral dissertation. Twenty-four participants (19 patients on hemodialysis, 2 family members, 2 nurses, and a physician) were selected through purposive and theoretical sampling until data saturation...
July 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28904012/identification-of-a-core-tp53-transcriptional-program-with-highly-distributed-tumor-suppressive-activity
#10
Zdenek Andrysik, Matthew D Galbraith, Anna L Guarnieri, Sara Zaccara, Kelly D Sullivan, Ahwan Pandey, Morgan MacBeth, Alberto Inga, Joaquín M Espinosa
The tumor suppressor TP53 is the most frequently mutated gene product in human cancer. Close to half of all solid tumors carry inactivating mutations in the TP53 gene, while in the remaining cases, TP53 activity is abrogated by other oncogenic events, such as hyperactivation of its endogenous repressors MDM2 or MDM4. Despite identification of hundreds of genes regulated by this transcription factor, it remains unclear which direct target genes and downstream pathways are essential for the tumor suppressive function of TP53...
September 13, 2017: Genome Research
https://www.readbyqxmd.com/read/28903044/engineering-synthetic-signaling-pathways-with-programmable-dcas9-based-chimeric-receptors
#11
Toni A Baeumler, Ahmed Ashour Ahmed, Tudor A Fulga
Synthetic receptors provide a powerful experimental tool for generation of designer cells capable of monitoring the environment, sensing specific input signals, and executing diverse custom response programs. To advance the promise of cellular engineering, we have developed a class of chimeric receptors that integrate a highly programmable and portable nuclease-deficient CRISPR/Cas9 (dCas9) signal transduction module. We demonstrate that the core dCas9 synthetic receptor (dCas9-synR) architecture can be readily adapted to various classes of native ectodomain scaffolds, linking their natural inputs with orthogonal output functions...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28902754/wrist-pain-in-gymnasts-a-review-of-common-overuse-wrist-pathology-in-the-gymnastics-athlete
#12
Holly J Benjamin, Sean C Engel, Debra Chudzik
Injury rates among gymnasts are among the highest of any sport at the high school and collegiate level per athletic exposure. The wrist has increased injury risk due to repetitive physical stresses predisposing it to acute injury, overuse, and degenerative damage. This article will review the most common overuse wrist injuries seen in gymnasts. Prompt evaluation and management is necessary to avoid the negative sequelae that can often accompany these injuries. Little is known about effective sport-specific injury prevention strategies, but general guidelines for overuse injury prevention including limiting excessive loading of the wrist, maintaining wrist joint flexibility, an emphasis on proper technique, and incorporating wrist and general core strengthening seem beneficial...
September 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28892420/eating-disorders-insights-from-imaging-and-behavioral-approaches-to-treatment
#13
Eric Stice, Heather Shaw
Understanding factors that contribute to eating disorders, which affect 13% of females, is critical to developing effective prevention and treatment programs. In this paper, we summarize results from prospective studies that identified factors predicting onset and persistence of eating disorders and core symptom dimensions. Next, implications for intervention targets for prevention, and treatment interventions from the risk- and maintenance-factor findings are discussed. Third, given that evidence suggests eating disorders are highly heritable, implying biological risk and maintenance factors for eating disorders, we offer working hypotheses about biological factors that might contribute to eating disorders, based on extant risk factor findings, theory, and cross-sectional studies...
August 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28892390/virtual-orbital-many-body-expansions-a-possible-route-towards-the-full-configuration-interaction-limit
#14
Janus J Eriksen, Filippo Lipparini, Jürgen Gauss
It is demonstrated how full configuration interaction (FCI) results in extended basis sets may be obtained to within sub-kJ/mol accuracy by decomposing the energy in terms of many-body expansions in the virtual orbitals of the molecular system at hand. This extension of the FCI application range lends itself to two unique features of the current approach, namely, that the total energy calculation can be performed entirely within considerably reduced orbital subspaces and may be so by means of embarrassingly parallel programming...
September 13, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28891745/motor-control-of-handwriting-in-the-developing-brain-a-review
#15
Sarah Palmis, Jeremy Danna, Jean-Luc Velay, Marieke Longcamp
This review focuses on the acquisition of writing motor aspects in adults, and in 5-to 12-year-old children without learning disabilities. We first describe the behavioural aspects of adult writing and dominant models based on the notion of motor programs. We show that handwriting acquisition is characterized by the transition from reactive movements programmed stroke-by-stroke in younger children, to an automatic control of the whole trajectory when the motor programs are memorized at about 10 years old. Then, we describe the neural correlates of adult writing, and the changes that could occur with learning during childhood...
September 11, 2017: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/28889831/methodological-and-practical-viewpoints-of-qualitative-driven-mixed-method-design-the-case-of-decentralisation-of-primary-healthcare-services-in-nepal
#16
Krishna Regmi
BACKGROUND: Although considerable attention has been paid to the use of quantitative methods in health research, there has been limited focus on decentralisation research using a qualitative-driven mixed method design. Decentralisation presents both a problematic concept and methodological challenges, and is more context-specific and is often multi-dimensional. Researchers often consider using more than one method design when researching phenomena is complex in nature. Aim To explore the effects of decentralisation on the provision of primary healthcare services...
September 11, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28887658/genetic-dissection-of-grain-traits-in-yamadanishiki-an-excellent-sake-brewing-rice-cultivar
#17
Satoshi Okada, Miki Suehiro, Kaworu Ebana, Kiyosumi Hori, Akio Onogi, Hiroyoshi Iwata, Masanori Yamasaki
The grain traits of Yamadanishiki, an excellent sake-brewing rice cultivar in Japan, are governed by multiple QTLs, namely, a total of 42 QTLs including six major QTLs. Japanese rice wine (sake) is produced using brewing rice (Oryza sativa L.) that carries traits desirable for sake-brewing, such as a larger grain size and higher white-core expression rate (WCE) compared to cooking rice cultivars. However, the genetic basis for these traits in brewing rice cultivars is still unclear. We performed analyses of quantitative trait locus (QTL) of grain and days to heading over 3 years on populations derived from crosses between Koshihikari, a cooking rice, and Yamadanishiki, an excellent sake-brewing rice...
September 8, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28886823/update-on-anterior-cruciate-ligament-rupture-and-care-in-the-female-athlete
#18
REVIEW
Jeremy M Burnham, Vonda Wright
As female athlete sports participation has continued to increase, the rate of anterior cruciate ligament (ACL) rupture in female athletes has also increased. Individualized, patient-specific treatment is crucial to achieving optimal outcomes; ACL reconstruction must accurately restore native ACL anatomy and address any concomitant injury to secondary stabilizers. Rehabilitation programs should target hip, core, and trunk neuromuscular control; allow adequate time for graft ligamentization; and address the psychosocial needs of the athlete...
October 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28886473/strategies-for-injury-prevention-in-brazilian-football-perceptions-of-physiotherapists-and-practices-of-premier-league-teams
#19
Maurício Couto Meurer, Marcelo Faria Silva, Bruno Manfredini Baroni
OBJECTIVES: To describe the physiotherapists perceptions and the current practices for injury prevention in elite football (soccer) clubs in Brazil. DESIGN: Cross-sectional study. SETTING: Group of Science in Sports & Exercise, Federal University of Healthy Sciences of Porto Alegre (Brazil). PARTICIPANTS: 16 of the 20 football clubs involved in the Brazilian premier league 2015. MAIN OUTCOME MEASURES: Physiotherapists answered a structured questionnaire...
July 25, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28883224/time-trend-in-interest-and-satisfaction-towards-clinical-training-and-academic-activities-among-early-career-cardiologists%C3%A3-the-japanese-circulation-society-post-graduate-training-survey
#20
Takashi Kohno, Shun Kohsaka, Yasuyoshi Takei, Keiichi Fukuda, Yukio Ozaki, Akira Yamashina
BACKGROUND: Satisfaction among early-career cardiologists is a key performance metric for cardiovascular (CV) educational programs. To assess the time trend in the interest and activities of early-career cardiologists regarding their training, we conducted web-based surveys in 2011 and 2015.Methods and Results:Early-career cardiologists were defined as physicians who planned to attend Japanese Circulation Society (JCS) annual meetings within 10 years of graduation. A total of 272 and 177 participants completed the survey for the years 2011 and 2015, respectively...
September 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
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