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https://www.readbyqxmd.com/read/27908498/hydrophilic-interaction-and-reversed-phase-mixed-mode-liquid-chromatography-coupled-to-high-resolution-tandem-mass-spectrometry-for-polar-lipids-analysis
#1
Sara Granafei, Pietro Azzone, Vito Alessandro Spinelli, Ilario Losito, Francesco Palmisano, Tommaso R I Cataldi
A hydrophilic interaction liquid chromatography (HILIC) fused-core column (150×2.1mm ID, 2.7μm particle size) and a short reversed-phase liquid chromatography (RPLC) column (20mm×2.1mm ID, 1.9μm) were serially coupled to perform mixed-mode chromatography (MMC) on complex mixtures of phospholipids (PL). Mobile phase composition and gradient elution program were, preliminarily, optimized using a mixture of phosphatidylcholines (PC), phosphatidylethanolamines (PE), their corresponding lyso-forms (LPC and LPE), and sphingomyelins (SM)...
November 25, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27907984/transnational-collaboration-for-faculty-development-in-health-professions-education-in-mongolia
#2
Hyun Bae Yoon, Jwa-Seop Shin, Seung-Hee Lee, Do-Hwan Kim, Minsun Sung, Nomin Amgalan, Tselmuun Chinzorig
PURPOSE: The Mongolian National University of Medical Sciences is the only national university in Mongolia and has produced more than 90% of health professionals in the country. Experts from Mongolia and Korea embarked on a collaborative effort to develop educational programs for faculty development based on the personal and professional needs of faculty members. This study aimed to evaluate the outcomes of those educational programs to determine whether this transnational collaboration was successful...
December 2016: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/27907983/north-korean-refugee-doctors-preliminary-examination-scores
#3
Sung Uk Chae, Jeong Hee Yang, Joon Seop Hyun, June Hee Kim, Seok Hoon Kang
PURPOSE: Although there have been studies emphasizing the re-education of North Korean (NK) doctors for post-unification of the Korean Peninsula, study on the content and scope of such re-education has yet to be conducted. Researchers intended to set the content and scope of re-education by a comparative analysis for the scores of the preliminary examination, which is comparable to the Korean Medical Licensing Examination (KMLE). METHODS: The scores of the first and second preliminary exams were analyzed by subject using the Wilcoxon signed rank test...
December 2016: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/27906014/acceptability-and-use-of-ready-to-use-supplementary-food-compared-to-corn-soy-blend-as-a-targeted-ration-in-an-hiv-program-in-rural-haiti-a-qualitative-study
#4
Anne G Beckett, Debbie Humphries, J Gregory Jerome, Jessica E Teng, Patrick Ulysse, Louise C Ivers
BACKGROUND: Ready-to-use supplementary food (RUSF) is increasingly used as a component of food rations for adults with HIV. METHODS: We undertook a qualitative study to evaluate the acceptability and use of peanut-based RUSF compared to corn-soy blend (CSB) among adults living with HIV in rural Haiti who had been enrolled in a prospective, randomized trial comparing the impact of those rations. A total of 13 focus groups were conducted with 84 participants-42 selected from the RUSF arm of the study, and 42 from the CSB arm-using a guide with pre-designated core topics and open-ended questions...
February 17, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27904794/pain-function-and-strength-outcomes-for-males-and-females-with-patellofemoral-pain-who-participate-in-either-a-hip-core-or-knee-based-rehabilitation-program
#5
Lori A Bolgla, Jennifer Earl-Boehm, Carolyn Emery, Karrie Hamstra-Wright, Reed Ferber
BACKGROUND: Hip exercise has been recommended for females with patellofemoral pain (PFP). It is unknown if males with PFP will benefit from a similar treatment strategy. HYPOTHESES/PURPOSE: The purpose of this study was to compare improvements in pain, function, and strength between males and females with PFP who participated in either a hip/core or knee rehabilitation program. The directional hypothesis was that females would respond more favorably to the hip/core rehabilitation program and males to the knee program...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27903156/american-society-of-clinical-oncology-obesity-initiative-rationale-progress-and-future-directions
#6
Jennifer A Ligibel, Dana Wollins
Obesity is increasingly being linked to the risk of developing and dying from cancer. In recognition of the growing contribution of obesity to cancer risk and outcomes, ASCO made obesity and cancer one of its core initiatives in 2014. The goals of this initiative included raising awareness of the relationship between obesity and cancer, providing tools and resources to oncology providers and patients to help encourage conversations regarding weight management in cancer survivors, fostering a robust research agenda, and advocating for access to evidence-based weight management programs for cancer survivors...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27902735/role-of-hepatic-specific-transcription-factors-and-polycomb-repressive-complex-2-during-induction-of-fibroblasts-to-hepatic-fate
#7
Shima Rastegar-Pouyani, Niusha Khazaei, Ping Wee, Abdulshakour Mohammadnia, Moein Yaqubi
Direct reprogramming using defined sets of transcription factors (TFs) is a recent strategy for generating induced hepatocytes (iHeps) from fibroblasts for use in regenerative medicine and drug development. Comprehensive studies detailing the regulatory role of TFs during this reprogramming process could help increase its efficiency. This study aimed to find the TFs with the greatest influences on the generation of iHeps from fibroblasts, and to further understand their roles in the regulation of the gene expression program...
2016: PloS One
https://www.readbyqxmd.com/read/27901606/protein-folding-prediction-in-a-cubic-lattice-in-hydrophobic-polar-model
#8
Nicola Yanev, Metodi Traykov, Peter Milanov, Borislav Yurukov
The tertiary structure of the proteins determines their functions. Therefore, the predicting of protein's tertiary structure, based on the primary amino acid sequence from long time, is the most important and challenging subject in biochemistry, molecular biology, and biophysics. One of the most popular protein structure prediction methods, called Hydrophobic-Polar (HP) model, is based on the observation that in polar environment hydrophobic amino acids are in the core of the molecule-in contact between them and more polar amino acids are in contact with the polar environment...
November 30, 2016: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/27899906/training-early-literacy-related-skills-to-which-degree-does-a-musical-training-contribute-to-phonological-awareness-development
#9
Sebastian Kempert, Regina Götz, Kristine Blatter, Catharina Tibken, Cordula Artelt, Wolfgang Schneider, Petra Stanat
Well-developed phonological awareness skills are a core prerequisite for early literacy development. Although effective phonological awareness training programs exist, children at risk often do not reach similar levels of phonological awareness after the intervention as children with normally developed skills. Based on theoretical considerations and first promising results the present study explores effects of an early musical training in combination with a conventional phonological training in children with weak phonological awareness skills...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27898662/kinase-inhibition-leads-to-hormesis-in-a-dual-phosphorylation-dephosphorylation-cycle
#10
Peter Rashkov, Ian P Barrett, Robert E Beardmore, Claus Bendtsen, Ivana Gudelj
Many antimicrobial and anti-tumour drugs elicit hormetic responses characterised by low-dose stimulation and high-dose inhibition. While this can have profound consequences for human health, with low drug concentrations actually stimulating pathogen or tumour growth, the mechanistic understanding behind such responses is still lacking. We propose a novel, simple but general mechanism that could give rise to hormesis in systems where an inhibitor acts on an enzyme. At its core is one of the basic building blocks in intracellular signalling, the dual phosphorylation-dephosphorylation motif, found in diverse regulatory processes including control of cell proliferation and programmed cell death...
November 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27893484/effects-of-pelvic-and-core-strength-training-on-high-school-cross-country-race-times
#11
Anne W Clark, Maggie K Goedeke, Rina Namvong, Derek E Rockwell, Bryan Jason Lehecka, Robert C Manske, Barbara S Smith
Effects of pelvic and core strength training on high school cross-country race times: A randomized control trial.There is only limited research examining the effect of pelvic and core strength training on running performance. Pelvic and core muscle fatigue is believed to contribute to excess motion along frontal and transverse planes which decreases efficiency in normal sagittal plane running motions. The purpose of this study was to determine if adding a six week pelvic and core strengthening program resulted in decreased race times in high school cross-country runners...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27893236/training-in-the-adolescent-brain-an-fmri-training-study-on-divergent-thinking
#12
Sietske W Kleibeuker, Claire E Stevenson, Laura van der Aar, Sandy Overgaauw, Anna C van Duijvenvoorde, Eveline A Crone
Prior research suggests that adolescence is a time of enhanced sensitivity for practice and learning. In this study we tested the neural correlates of divergent thinking training in 15- to 16-year-old adolescents relative to an age-matched active control group. All participants performed an alternative uses task, a valid measure to test divergent thinking, while functional magnetic resonance imaging (fMRI) images were acquired before and after a training program. In between the 2 scanning sessions the experimental group completed 2 weeks of divergent thinking training (8 sessions) and the control group completed 2 weeks of rule switching training (8 session)...
November 28, 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27890870/improving-the-quality-of-postgraduate-education-in-traditional-japanese-kampo-medicine-for-junior-residents-an-exploratory-survey-conducted-in-five-institutions-in-the-tohoku-area
#13
Shin Takayama, Seiichi Kobayashi, Soichiro Kaneko, Masao Tabata, Shinya Sato, Keiichi Ishikawa, Saya Suzuki, Ryutaro Arita, Natsumi Saito, Tetsuharu Kamiya, Hitoshi Nishikawa, Yuka Ikeno, Junichi Tanaka, Minoru Ohsawa, Akiko Kikuchi, Takehiro Numata, Hitoshi Kuroda, Michiaki Abe, Satoru Ishibashi, Nobuo Yaegashi, Tadashi Ishii
Traditional Japanese (Kampo) medicine has been widely applied in general medicine in Japan. In 2001, the model core curriculum for Japanese medical education was revised to include Kampo medicine. Since 2007, all 80 Japanese medical schools have incorporated it within their programs. However, postgraduate training or instruction of Kampo medicine has not been recognized as a goal for the clinical training of junior residents by Japan's Ministry of Health, Labour and Welfare; little is known about postgraduate Kampo medicine education...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27889445/mindfulness-training-for-health-profession-students-the-effect-of-mindfulness-training-on-psychological-well-being-learning-and-clinical-performance-of-health-professional-students-a-systematic-review-of-randomized-and-non-randomized-controlled-trials
#14
REVIEW
Janet McConville, Rachael McAleer, Andrew Hahne
BACKGROUND: High levels of stress have been identified in medical students and increasingly in other health profession student population groups. As stress can affect psychological well-being and interfere with learning and clinical performance, there is a clear argument for universities to include health professional student well-being as an outcome in core curriculum. Mindfulness training is a potential construct to manage stress and enhance academic success. OBJECTIVES: The aims of this systematic review were to assess the effectiveness of mindfulness training in medical and other health professional student population groups and to compare the effectiveness of the different mindfulness-based programs...
October 24, 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/27887610/integral-strategy-to-supportive-care-in-breast-cancer-survivors-through-occupational-therapy-and-a-m-health-system-design-of-a-randomized-clinical-trial
#15
Mario Lozano-Lozano, Lydia Martín-Martín, Noelia Galiano-Castillo, Francisco Álvarez-Salvago, Irene Cantarero-Villanueva, Carolina Fernández-Lao, Carmen Sánchez-Salado, Manuel Arroyo-Morales
BACKGROUND: Technological support using e-health mobile applications (m-health) is a promising strategy to improve the adherence to healthy lifestyles in breast cancer survivors (excess in energy intake or low physical activity are determinants of the risk of recurrence, second cancers and cancer mortality). Moreover, cancer rehabilitation programs supervised by health professionals are needed due to the inherent characteristics of these breast cancer patients. Our main objective is to compare the clinical efficacy of a m-health lifestyle intervention system alone versus an integral strategy to improve Quality of Life in breast cancer survivors...
November 25, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27887574/fluxfix-automatic-isotopologue-normalization-for-metabolic-tracer-analysis
#16
Sophie Trefely, Peter Ashwell, Nathaniel W Snyder
BACKGROUND: Isotopic tracer analysis by mass spectrometry is a core technique for the study of metabolism. Isotopically labeled atoms from substrates, such as [(13)C]-labeled glucose, can be traced by their incorporation over time into specific metabolic products. Mass spectrometry is often used for the detection and differentiation of the isotopologues of each metabolite of interest. For meaningful interpretation, mass spectrometry data from metabolic tracer experiments must be corrected to account for the naturally occurring isotopologue distribution...
November 25, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27883947/social-cognitive-predictors-of-treatment-outcome-in-cannabis-dependence
#17
Matthew J Gullo, Marya Matveeva, Gerald F X Feeney, Ross McD Young, Jason P Connor
BACKGROUND: Drug-related outcomes expectancies and refusal self-efficacy are core components of Social Cognitive Theory. Both predict treatment outcome in alcohol use disorders. Few studies have reported expectancies and refusal self-efficacy in cannabis dependence. None have examined both, although both constructs are key targets in Cognitive-Behavioural Therapy (CBT). This study tests the predictive role of expectancies and refusal self-efficacy in treatment outcome for cannabis dependence...
November 4, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27882067/bioinformatic-identification-of-rare-codon-clusters-rccs-in-hbv-genome-and-evaluation-of-rccs-in-proteins-structure-of-hepatitis-b-virus
#18
Mojtaba Mortazavi, Mohammad Zarenezhad, Saeid Gholamzadeh, Seyed Moayed Alavian, Mohammad Ghorbani, Reza Dehghani, Abdorrasoul Malekpour, Mohammadhasan Meshkibaf, Ali Fakhrzad
BACKGROUND: Hepatitis B virus (HBV) as an infectious disease that has nine genotypes (A - I) and a 'putative' genotype J. OBJECTIVES: The aim of this study was to identify the rare codon clusters (RCC) in the HBV genome and to evaluate these RCCs in the HBV proteins structure. METHODS: For detection of protein family accession numbers (Pfam) in HBV proteins, the UniProt database and Pfam search tool were used. Protein family accession numbers is a comprehensive and accurate collection of protein domains and families...
October 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27881076/clustering-of-disulfide-rich-peptides-provides-scaffolds-for-hit-discovery-by-phage-display-application-to-interleukin-23
#19
David T Barkan, Xiao-Li Cheng, Herodion Celino, Tran T Tran, Ashok Bhandari, Charles S Craik, Andrej Sali, Mark L Smythe
BACKGROUND: Disulfide-rich peptides (DRPs) are found throughout nature. They are suitable scaffolds for drug development due to their small cores, whose disulfide bonds impart extraordinary chemical and biological stability. A challenge in developing a DRP therapeutic is to engineer binding to a specific target. This challenge can be overcome by (i) sampling the large sequence space of a given scaffold through a phage display library and by (ii) panning multiple libraries encoding structurally distinct scaffolds...
November 23, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27878533/gender-perspectives-in-resilience-vulnerability-and-adaptation-to-global-environmental-change
#20
EDITORIAL
Federica Ravera, Irene Iniesta-Arandia, Berta Martín-López, Unai Pascual, Purabi Bose
The main goal of this special issue is to offer a room for interdisciplinary and engaged research in global environmental change (GEC), where gender plays a key role in building resilience and adaptation pathways. In this editorial paper, we explain the background setting, key questions and core approaches of gender and feminist research in vulnerability, resilience and adaptation to GEC. Highlighting the interlinkages between gender and GEC, we introduce the main contributions of the collection of 11 papers in this special issue...
December 2016: Ambio
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