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https://www.readbyqxmd.com/read/28731104/a-new-droplet-forming-fluidic-junction-for-the-generation-of-highly-compartmentalised-capsules
#1
J Li, D A Barrow
A new oscillatory microfluidic junction is described, which enables the consistent formation of highly uniform and complex double emulsions, and is demonstrated for the encapsulation of four different reagents within the inner droplets (called cores) of the double emulsion droplets. Once the double emulsion droplets had attained a spherical form, the cores assumed specific 3D arrangements, the orchestration of which appeared to depend upon the specific emulsion morphology. Such double emulsion droplets were used as templates to produce highly compartmentalised microcapsules and multisomes...
July 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28729233/dynamo-a-modular-platform-for-monitoring-process-outcome-and-algorithm-based-treatment-planning-in-psychotherapy
#2
Tim Kaiser, Anton Rupert Laireiter
BACKGROUND: In recent years, the assessment of mental disorders has become more and more personalized. Modern advancements such as Internet-enabled mobile phones and increased computing capacity make it possible to tap sources of information that have long been unavailable to mental health practitioners. OBJECTIVE: Software packages that combine algorithm-based treatment planning, process monitoring, and outcome monitoring are scarce. The objective of this study was to assess whether the DynAMo Web application can fill this gap by providing a software solution that can be used by both researchers to conduct state-of-the-art psychotherapy process research and clinicians to plan treatments and monitor psychotherapeutic processes...
July 20, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28729009/development-of-entrustable-professional-activities-for-hospice-and-palliative-medicine-fellowship-training-in-the-united-states
#3
Lindy H Landzaat, Michael D Barnett, Gary T Buckholz, Jillian L Gustin, Jennifer M Hwang, Stacie K Levine, Tomasz Okon, Steven M Radwany, Holly B Yang, John Encandela, Laura J Morrison
CONTEXT: Entrustable Professional Activities (EPAs) represent the key physician tasks of a specialty. Once a trainee demonstrates competence in an activity, they can then be 'entrusted' to practice without supervision(1). A physician workgroup of the American Academy of Hospice and Palliative Medicine (AAHPM) sought to define Hospice and Palliative Medicine (HPM) EPAs. OBJECTIVE: To describe the development of a set of consensus EPAs for HPM fellowship training in the United States...
July 17, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28728976/effect-of-alkylaminophenols-on-growth-inhibition-and-apoptosis-of-bone-cancer-cells
#4
Phuong Doan, Tien Nguyen, Olli Yli-Harja, Nuno R Candeias, Meenakshisundaram Kandhavelu
In this work, we report the anticancer properties of a series of 11 chemically synthesized alkylaminophenols against human osteosarcoma U2OS tumor cell line. Several assays including cytotoxicity, inhibitor kinetic study, cell migration, Annexin-V/PI double staining, reactive oxygen species (ROS) and caspase 3/7 assays were conducted on this cell line. Cytotoxic 2-((3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl)phenol was determined to have an IC50 value of 36.6μM against U2OS cells and it also inhibits the cell growth in time-dependent manner...
July 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28727806/genocore-a-simple-and-fast-algorithm-for-core-subset-selection-from-large-genotype-datasets
#5
Seongmun Jeong, Jae-Yoon Kim, Soon-Chun Jeong, Sung-Taeg Kang, Jung-Kyung Moon, Namshin Kim
Selecting core subsets from plant genotype datasets is important for enhancing cost-effectiveness and to shorten the time required for analyses of genome-wide association studies (GWAS), and genomics-assisted breeding of crop species, etc. Recently, a large number of genetic markers (>100,000 single nucleotide polymorphisms) have been identified from high-density single nucleotide polymorphism (SNP) arrays and next-generation sequencing (NGS) data. However, there is no software available for picking out the efficient and consistent core subset from such a huge dataset...
2017: PloS One
https://www.readbyqxmd.com/read/28726481/a-randomized-controlled-trial-of-an-online-modular-active-learning-training-program-for-behavioral-activation-for-depression
#6
Ajeng J Puspitasari, Jonathan W Kanter, Andrew M Busch, Rachel Leonard, Shira Dunsiger, Shawn Cahill, Christopher Martell, Kelly Koerner
OBJECTIVE: This randomized-controlled trial assessed the efficacy of a trainer-led, active-learning, modular, online behavioral activation (BA) training program compared with a self-paced online BA training with the same modular content. METHOD: Seventy-seven graduate students (M = 30.3 years, SD = 6.09; 76.6% female) in mental health training programs were randomly assigned to receive either the trainer-led or self-paced BA training. Both trainings consisted of 4 weekly sessions covering 4 core BA strategies...
August 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28726461/laverne-vern-c-johnson-1925-2016
#7
Paul Nelson
Presents an obituary for Laverne (Vern) C. Johnson, who died at his home in La Mesa, California on October 1, 2016. Vern was a clinical psychologist who for two decades focused on a major program of research on sleep and biological rhythms, with particular emphasis on the relation of sleep loss and recovery to human performance, a matter of particular relevance to military service operations, in which variable work shift schedules and sustained performance over extended time periods are common. His publications attest to a core value he advanced throughout his career, namely, that scientific research at its best is a collaborative, team endeavor...
July 2017: American Psychologist
https://www.readbyqxmd.com/read/28723567/cold-inducible-sirt6-regulates-thermogenesis-of-brown-and-beige-fat
#8
Lu Yao, Xiaona Cui, Qi Chen, Xiaoying Yang, Fude Fang, Jun Zhang, Guoqing Liu, Wanzhu Jin, Yongsheng Chang
Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic function of brown adipocytes, causing a morphological "whitening" of brown fat, reduced oxygen (O2) consumption, obesity, decreased core body temperature, and cold sensitivity. Fat SIRT6-deleted mice exhibit increased blood glucose levels, severe insulin resistance, and hepatic steatosis...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28721904/treatment-planning-system-calculation-errors-are-present-in-most-imaging-and-radiation-oncology-core-houston-phantom-failures
#9
James R Kerns, Francesco Stingo, David S Followill, Rebecca M Howell, Adam Melancon, Stephen F Kry
PURPOSE: The anthropomorphic phantom program at the Houston branch of the Imaging and Radiation Oncology Core (IROC-Houston) is an end-to-end test that can be used to determine whether an institution can accurately model, calculate, and deliver an intensity modulated radiation therapy dose distribution. Currently, institutions that do not meet IROC-Houston's criteria have no specific information with which to identify and correct problems. In the present study, an independent recalculation system was developed to identify treatment planning system (TPS) calculation errors...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28719380/comparison-of-different-antibody-clones-for-immunohistochemistry-detection-of-programmed-cell-death-ligand-1-pd-l1-on-non-small-cell-lung-carcinoma
#10
Edwin R Parra, Pamela Villalobos, Barbara Mino, Jaime Rodriguez-Canales
Programmed cell death ligand 1 (PD-L1) is a major immune checkpoint protein that mediates antitumor immune suppression and response. Preliminary data suggest that its detection using immunohistochemistry (IHC) in formalin-fixed and paraffin-embedded tissues may predict clinical response to PD-1/PD-L1 therapy. In diagnostic pathology, it is essential to count with a validated IHC that can reliably detect PD-L1-positive cases. The present study was conducted to compare and validate different PD-L1 commercial clones and identify which ones can be reliably used by surgical pathologist to detect PD-L1 expression in human cancer tissues...
July 17, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28717873/orchestration-of-h3k27-methylation-mechanisms-and-therapeutic-implication
#11
REVIEW
Mei-Ren Pan, Ming-Chuan Hsu, Li-Tzong Chen, Wen-Chun Hung
Histone proteins constitute the core component of the nucleosome, the basic unit of chromatin. Chemical modifications of histone proteins affect their interaction with genomic DNA, the accessibility of recognized proteins, and the recruitment of enzymatic complexes to activate or diminish specific transcriptional programs to modulate cellular response to extracellular stimuli or insults. Methylation of histone proteins was demonstrated 50 years ago; however, the biological significance of each methylated residue and the integration between these histone markers are still under intensive investigation...
July 17, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28717819/atrophic-degeneration-of-cerebellum-impairs-both-the-reactive-and-the-proactive-control-of-movement-in-the-stop-signal-paradigm
#12
Giusy Olivito, Emiliano Brunamonti, Silvia Clausi, Pierpaolo Pani, Francesca R Chiricozzi, Margherita Giamundo, Marco Molinari, Maria Leggio, Stefano Ferraina
The cognitive control of movement suppression, including performance monitoring, is one of the core properties of the executive system. A complex cortical and subcortical network involving cerebral cortex, thalamus, subthalamus, and basal ganglia has been regarded as the neural substrate of inhibition of programmed movements. Using the countermanding task, a suitable tool to explore behavioral components of movement suppression, the contribution of the cerebellum in the proactive control and monitoring of voluntary action has been recently described in patients affected by focal lesions involving in particular the cerebellar dentate nucleus...
July 17, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28717759/quality-oncology-practice-initiative-can-guide-and-improve-oncology-providers-training-in-brazil
#13
Cristiane Decat Bergerot, Errol J Philip, Paulo Gustavo Bergerot, Simone Elias, Daiane Pereira Guimarães, Nora Manoukian Forones, Otavio Cesar Carvalho Guimarães Baiocchi, Nildo Alves Batista, Edvane Birelo Lopes De Domenico
PURPOSE: It has become crucial to translate scientific findings and to find ways by which to mobilize local resources to improve the quality and accessibility of cancer care in developing countries. This study seeks to provide insight into challenge through examining differences in clinician documentation of patients with cancer treated at a Brazilian Public University Hospital. METHODS: ASCO Quality Oncology Practice Initiative (QOPI) measures were used to examine the care provided in the departments of breast, colorectal, lymphoma, gynecology, and lung cancers...
June 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28714764/abdominal-hollowing-reduces-lateral-trunk-displacement-during-single-leg-squats-in-healthy-females-but-does-not-affect-peak-hip-abduction-angle-or-knee-abductio-angle-moment
#14
Lukas D Linde, Jessica Archibald, Eve C Lampert, John Z Srbely
CONTEXT: Females suffer 4-6 times more non-contact anterior cruciate ligament (ACL) injuries than males due to neuromuscular control deficits of the hip musculature leading to increases in hip adduction angle, knee abduction angle, and knee abduction moment during dynamic tasks such as single-leg squats. Lateral trunk displacement has been further related to ACL injury risk in females, leading to the incorporation of core strength/stability exercises in ACL preventative training programs...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28713802/developing-a-mentorship-program-in-laos
#15
Helen Nita Catton
Skills strengthening and capacity building for maternal and newborn health (MNH) providers are essential to ensure quality care for mothers and newborns. There is, however, limited research regarding what constitutes an effective model in low-income countries. The Lao People's Democratic Republic (Laos) has some of the region's worst outcomes for neonatal and maternal mortality. Moreover, with a 23-year hiatus in midwifery training, which ended approximately 7 years ago, there is a cadre of new and inexperienced midwives in practice without support systems, skills, or continuing professional development opportunities...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28713365/what-s-normal-immune-profiling-of-human-milk-from-healthy-women-living-in-different-geographical-and-socioeconomic-settings
#16
Lorena Ruiz, Irene Espinosa-Martos, Cristina García-Carral, Susana Manzano, Michelle K McGuire, Courtney L Meehan, Mark A McGuire, Janet E Williams, James Foster, Daniel W Sellen, Elizabeth W Kamau-Mbuthia, Egidioh W Kamundia, Samwel Mbugua, Sophie E Moore, Linda J Kvist, Gloria E Otoo, Kimberly A Lackey, Katherine Flores, Rossina G Pareja, Lars Bode, Juan M Rodríguez
Human milk provides a very wide range of nutrients and bioactive components, including immune factors, human milk oligosaccharides, and a commensal microbiota. These factors are essential for interconnected processes including immunity programming and the development of a normal infant gastrointestinal microbiome. Newborn immune protection mostly relies on maternal immune factors provided through milk. However, studies dealing with an in-depth profiling of the different immune compounds present in human milk and with the assessment of their natural variation in healthy women from different populations are scarce...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28711646/rural-rotations-at-core-rarefied-exposure-or-real-experience
#17
Christopher Brown, Tarig Abdelrahman, Neil Patel, Awen Iorwerth, John Pollitt, Mark Holt, Wyn G Lewis
OBJECTIVE: Surgical rotations involving rural General Hospitals (rGH) are frequently associated with recruitment challenges, partly because of adverse perceptions regarding distances from social support networks and training opportunities. The aim of this study was to determine the outcomes of core surgical training rotations involving rGHs when compared with urban hospitals in a single UK Deanery. DESIGN: Online Intercollegiate Surgical Curriculum Programme portfolios from 163 core surgical trainees (CST) were examined related to postlocation, operative experience, workplace-based assessments, and academic achievement...
July 12, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28709585/patients-come-from-populations-and-populations-contain-patients-a-two-stage-scientific-and-ethics-review-the-next-adaptation-for-single-institutional-review-boards
#18
David Knopman, Eli Alford, Kaitlin Tate, Mark Long, Ara S Khachaturian
INTRODUCTION: For nearly 50 years, institutional review boards (IRB) and independent ethics committees have featured local oversight as a core function of research ethics reviews. However growing complexity in Alzheimer's clinical research suggests current approaches to research volunteer safety is hampering development of new therapeutics. As a partial response to this challenge, the NIH has mandated that all NIH-funded multi-site studies will use a single Institutional Review Board...
July 11, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28708963/a-qualitative-study-adopting-a-user-centered-approach-to-design-and-validate-a-brain-computer-interface-for-cognitive-rehabilitation-for-people-with-brain-injury
#19
Suzanne Martin, Elaine Armstrong, Eileen Thomson, Eloisa Vargiu, Marc Solà, Stefan Dauwalder, Felip Miralles, Jean Daly Lynn
Cognitive rehabilitation is established as a core intervention within rehabilitation programs following a traumatic brain injury (TBI). Digitally enabled assistive technologies offer opportunities for clinicians to increase remote access to rehabilitation supporting transition into home. Brain Computer Interface (BCI) systems can harness the residual abilities of individuals with limited function to gain control over computers through their brain waves. This paper presents an online cognitive rehabilitation application developed with therapists, to work remotely with people who have TBI, who will use BCI at home to engage in the therapy...
July 14, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28706729/a-retrospective-review-of-the-pediatric-development-clinic-implementation-a-model-to-improve-medical-nutritional-and-developmental-outcomes-of-at-risk-under-five-children-in-rural-rwanda
#20
Eric Ngabireyimana, Christine Mutaganzwa, Catherine M Kirk, Ann C Miller, Kim Wilson, Evodia Dushimimana, Olivier Bigirumwami, Evelyne S Mukakabano, Fulgence Nkikabahizi, Hema Magge
BACKGROUND: As more high-risk newborns survive the neonatal period, they remain at significant medical, nutritional, and developmental risk. However, no follow-up system for early intervention exists in most developing countries. In 2014, a novel Pediatric Development Clinic (PDC) was implemented to provide comprehensive follow-up to at-risk under-five children, led by nurses and social workers in a district hospital and surrounding health centers in rural Rwanda. METHODS: At each PDC visit, children undergo clinical/nutritional assessment and caregivers participate in counseling sessions...
2017: Maternal Health, Neonatology and Perinatology
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