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https://www.readbyqxmd.com/read/29349199/efficiency-or-equity-simulating-the-impact-of-high-risk-and-population-intervention-strategies-for-the-prevention-of-disease
#1
Jonathan M Platt, Katherine M Keyes, Sandro Galea
Maximizing both efficiency and equity are core considerations for population health. These considerations can result in tension in population health science as we seek to improve overall population health while achieving equitable health distributions within populations. Limited work has explored empirically the consequences of different population health intervention strategies on the burden of disease and on within- and between-group differences in disease. To address this gap, we compared the impact of four simulated interventions using data from the National Health and Nutrition Examination Survey...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29346698/procedural-knowledge-and-skills-of-residents-entering-canadian-family-medicine-programs-in-alberta
#2
Juan Antonio Garcia-Rodriguez, James A Dickinson, Grace Perez, David Ross, Lilian Au, Shelley Ross, Oksana Babenko, Ian Johnston
BACKGROUND AND OBJECTIVES: Incoming family medicine (FM) residents start residency with different levels of procedural training. Understanding their baseline skill level is necessary to plan the educational experiences and teaching methods that will provide the desired knowledge, skills, and attitudes related to performing medical procedures. METHODS: A survey of 69 procedures based on the core list issued by the College of Family Physicians of Canada was administered to incoming residents in Alberta (Calgary and Edmonton FM programs)...
January 2018: Family Medicine
https://www.readbyqxmd.com/read/29346540/blood-and-lymphatic-vessels-contribute-to-the-impact-of-the-immune-microenvironment-on-clinical-outcome-in-non-small-cell-lung-cancer
#3
Giovanna Armani, Denise Madeddu, Giulia Mazzaschi, Giovanni Bocchialini, Francesco Sogni, Caterina Frati, Bruno Lorusso, Angela Falco, Costanza Annamaria Lagrasta, Stefano Cavalli, Chiara Mangiaracina, Rocchina Vilella, Gabriella Becchi, Letizia Gnetti, Emilia Corradini, Eugenio Quaini, Konrad Urbanek, Matteo Goldoni, Paolo Carbognani, Luca Ampollini, Federico Quaini
OBJECTIVES: Lymphangiogenesis plays a critical role in the immune response, tumour progression and therapy effectiveness. The aim of this study was to determine whether the interplay between the lymphatic and the blood microvasculature, tumour-infiltrating lymphocytes and the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint constitutes an immune microenvironment affecting the clinical outcome of patients with non-small-cell lung cancer. METHODS: Samples from 50 squamous cell carcinomas and 42 adenocarcinomas were subjected to immunofluorescence to detect blood and lymphatic vessels...
January 15, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29344791/sages-s-advanced-gi-mis-fellowship-curriculum-pilot-project
#4
Joshua J Weis, Matthew Goldblatt, Aurora Pryor, Brian J Dunkin, L Michael Brunt, Daniel B Jones, Daniel J Scott
BACKGROUND: The American health care system faces deficits in quality and quantity of surgeons. SAGES is a major stakeholder in surgical fellowship training and is responsible for defining the curriculum for the Advanced GI/MIS fellowship. SAGES leadership is actively adapting this curriculum. METHODS: The process of reform began in 2014 through a series of iterative meetings and discussions. A working group within the Resident and Fellow Training Committee reviewed case log data from 2012 to 2015...
January 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29342307/using-phylogenomic-data-to-explore-the-effects-of-relaxed-clocks-and-calibration-strategies-on-divergence-time-estimation-primates-as-a-test-case
#5
Mario Dos Reis, Gregg F Gunnell, José Barba-Montoya, Alex Wilkins, Ziheng Yang, Anne D Yoder
Primates have long been a test case for the development of phylogenetic methods for divergence time estimation. Despite a large number of studies, however, the timing of origination of crown Primates relative to the K-Pg boundary and the timing of diversification of the main crown groups remain controversial. Here we analysed a dataset of 372 taxa (367 Primates and 5 outgroups, 3.4 million aligned base pairs) that includes nine primate genomes. We systematically explore the effect of different interpretations of fossil calibrations and molecular clock models on primate divergence time estimates...
January 12, 2018: Systematic Biology
https://www.readbyqxmd.com/read/29341027/developing-deep-learning-applications-for-life-science-and-pharma-industry
#6
Daniel Siegismund, Vasily Tolkachev, Stephan Heyse, Beate Sick, Oliver Duerr, Stephan Steigele
Deep Learning has boosted artificial intelligence over the past 5 years and is seen now as one of the major technological innovation areas, predicted to replace lots of repetitive, but complex tasks of human labor within the next decade. It is also expected to be 'game changing' for research activities in pharma and life sciences, where large sets of similar yet complex data samples are systematically analyzed. Deep learning is currently conquering formerly expert domains especially in areas requiring perception, previously not amenable to standard machine learning...
January 16, 2018: Drug Research
https://www.readbyqxmd.com/read/29340616/pychimera-use-ucsf-chimera-modules-in-any-python-2-7-project
#7
Jaime Rodríguez-Guerra Pedregal, Jean-Didier Maréchal
Motivation: UCSF Chimera (Pettersen et al., 2004) is a powerful visualization tool remarkably present in the computational chemistry and structural biology communities. Built on a C ++ core wrapped under a Python 2.7 environment, one could expect to easily import UCSF Chimera's arsenal of resources in custom scripts or software projects. Nonetheless, this is not readily possible if the script is not executed within UCSF Chimera due to the isolation of the platform. UCSF ChimeraX (Goddard et al...
January 11, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29339930/research-evaluation-support-services-in-biomedical-libraries
#8
Karen Elizabeth Gutzman, Michael E Bales, Christopher W Belter, Thane Chambers, Liza Chan, Kristi L Holmes, Ya-Ling Lu, Lisa A Palmer, Rebecca C Reznik-Zellen, Cathy C Sarli, Amy M Suiter, Terrie R Wheeler
Objective: The paper provides a review of current practices related to evaluation support services reported by seven biomedical and research libraries. Methods: A group of seven libraries from the United States and Canada described their experiences with establishing evaluation support services at their libraries. A questionnaire was distributed among the libraries to elicit information as to program development, service and staffing models, campus partnerships, training, products such as tools and reports, and resources used for evaluation support services...
January 2018: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/29337983/wor1-establishes-opaque-cell-fate-through-inhibition-of-the-general-co-repressor-tup1-in-candida-albicans
#9
Selma S Alkafeef, Clinton Yu, Lan Huang, Haoping Liu
The pathogenic fungus Candida albicans can undergo phenotypic switching between two heritable states: white and opaque. This phenotypic plasticity facilitates its colonization in distinct host niches. The master regulator WOR1 is exclusively expressed in opaque phase cells. Positive feedback regulation by Wor1 on the WOR1 promoter is essential for opaque formation, however the underlying mechanism of how Wor1 functions is not clear. Here, we use tandem affinity purification coupled with mass spectrometry to identify Wor1-interacting proteins...
January 16, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29335743/-prevention-of-cardiovascular-diseases
#10
J H Prochaska, N Arnold, C Jünger, T Münzel, P S Wild
The incidence of cardiovascular diseases can be reduced by the early detection and targeted treatment of risk factors and subclinical forms of the disease. Primary prevention provides several opportunities for successful interventions. In addition to a drug-based therapy, especially life style-modifying measures, such as physical activity, normalization of body weight, consistent nicotine abstinence and the consideration of psychosocial aspects represent core components of prevention programs. Healthcare data indicate that risk factors still often remain undetected and that the full potential of risk factor management has not yet been fully exploited at a population level...
January 15, 2018: Herz
https://www.readbyqxmd.com/read/29332636/implementation-of-an-electronic-routine-outcome-monitoring-at-an-inpatient-unit-for-psychosomatic-medicine
#11
Jonas Egeter, Katharina Hüfner, Monika Sztankay, Bernhard Holzner, Barbara Sperner-Unterweger
BACKGROUND: Patient-reported outcomes (PROs) can be part of an electronic routine outcome monitoring (eROM). eROM can improve patient involvement, treatment outcomes and simplify scientific data assessment. Available studies on eROM focus on its evaluation only and lack a detailed description of the prior implementation procedure. OBJECTIVE: The aim was to implement an eROM assessment at a division of Psychosomatic Medicine and provide a detailed description of the implementation procedure...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29332470/a-school-based-neuromuscular-training-program-and-sport-related-injury-incidence-a-prospective-randomized-controlled-clinical-trial
#12
Kim D Barber Foss, Staci Thomas, Jane C Khoury, Gregory D Myer, Timothy E Hewett
CONTEXT:   An estimated 40 million school-aged children (age range = 5-18 years) participate annually in sports in the United States, generating approximately 4 million sport-related injuries and requiring 2.6 million emergency department visits at a cost of nearly $2 billion. OBJECTIVE:   To determine the effects of a school-based neuromuscular training (NMT) program on sport-related injury incidence across 3 sports at the high school and middle school levels, focusing particularly on knee and ankle injuries...
January 13, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29332294/detection-of-mapk3-6-phosphorylation-during-hypersensitive-response-hr-associated-programmed-cell-death-in-plants
#13
Qingyu Wu, David Jackson
Programmed cell death (PCD) is an essential component of development, biotic and abiotic responses. Hypersensitive response (HR)-associated cell death activated under pathogen attack is one of the most dramatic manifestations of PCD in plants. Signal transduction through mitogen-activated protein kinase (MAPK) cascades, a very conserved signaling pathway across eukaryotes, is a core mediator for HR-associated PCD. Therefore, monitoring MAPK activation enables the mechanisms underlying HR-associated PCD to be elucidated...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29332057/evaluation-of-thickness-of-cad-cam-fabricated-zirconia-cores-by-digital-microscope
#14
Syed Rashid Habib, Asim Khaled Al Otaibi, Talal Ali Al Anazi, Samer Mosleh Al Anazi
Despite several advantages of digitalized workflow, researchers have noted discrepancies in the precision and trueness. This study investigated the accuracy in the final thickness of Zirconia (Zr) cores fabricated by five CAD/CAM systems. Standardized manufacturing of the cores with 1 mm thickness were carried out. Cores were then sectioned into two halves and measurement made with Digital Microscope at 5 points in micrometers. Overall, mean thickness for the groups was 1048.81 ± 94.01, which was 48 μm higher than the thickness programmed in the software...
December 29, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29329988/rethinking-medicaid-coverage-and-payment-policy-to-promote-high-value-care-the-case-of-long-acting-reversible-contraception
#15
Veronica X Vela, Elizabeth W Patton, Darshak Sanghavi, Susan F Wood, Peter Shin, Sara Rosenbaum
CONTEXT: Long-acting reversible contraception (LARC) is the most effective reversible method to prevent unplanned pregnancies. Variability in state-level policies and the high cost of LARC could create substantial inconsistencies in Medicaid coverage, despite federal guidance aimed at enhancing broad access. This study surveyed state Medicaid payment policies and outreach activities related to LARC to explore the scope of services covered. METHODS: Using publicly available information, we performed a content analysis of state Medicaid family planning and LARC payment policies...
January 9, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29328844/cost-awareness-of-disposable-surgical-equipment-and-strategies-for-improvement-cross-sectional-survey-and-literature-review
#16
James Wf Kynaston, Thomas Smith, Jeremy Batt
A significant healthcare funding gap has been predicted over the coming years. NHS England has made transparency and cost efficiency a key priority. Healthcare technology accounts for a large portion of healthcare expenditure. The aim of the study was to establish the cost awareness of theatre staff for disposable surgical equipment and to review the current evidence around improving cost awareness. A cross sectional survey was performed. A questionnaire was distributed to consultants, registrars, core surgical trainees and theatre scrub practitioners within an NHS foundation trust and analysed using Microsoft excel 2010...
October 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29327593/the-impact-of-age-and-gender-on-the-icf-based-assessment-of-chronic-low-back-pain
#17
Elisabeth Fehrmann, Simone Kotulla, Linda Fischer, Thomas Kienbacher, Kerstin Tuechler, Patrick Mair, Gerold Ebenbichler, Birgit Paul
PURPOSE: To evaluate the impact of age and gender on the international classification of functioning, disability and health (ICF)-based assessment for chronic low back pain. METHODS: Two hundred forty-four chronic low back pain patients (52% female) with a mean age of 49 years (SD =17.64) were interviewed with the comprehensive ICF core set for activities and participation, and environmental factors. After conducting explorative factor analysis, the impact of age and gender on the different factors was analyzed using analyzes of variances...
January 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29326404/-effects-of-breastfeeding-interventions-on-breastfeeding-rates-at-1-3-and-6-months-postpartum-a-systematic-review-and-meta-analysis
#18
REVIEW
Seol Hui Park, Seang Ryu
PURPOSE: This study was a systematic review and meta-analysis designed to evaluate the effects of breastfeeding intervention on breastfeeding rates. METHODS: Based on the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), a systematic search was conducted using eight core electronic databases and other sources including gray literature from January 9 to 19, 2017. Two reviewers independently select the studies and assessed methodological risk of bias of studies using the Cochrane criteria...
December 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29326003/the-efficacy-of-infection-prevention-and-control-committees-in-lesotho-a-qualitative-study
#19
Eltony Mugomeri
BACKGROUND: The implementation of the core components of infection prevention and control (IPC) recommended by the World Health Organization faces severe challenges, particularly in developing countries. Given that hospital IPC committees in these countries are the key implementers of IPC, there is a need to evaluate their effectiveness. This study qualitatively evaluated the effectiveness of IPC committees in the southern African country of Lesotho with the aim of identifying themes for policy discourse on improving IPC practice in the country...
January 9, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29318916/promoting-physical-activity-using-a-wearable-activity-tracker-in-college-students-a-cluster-randomized-controlled-trial
#20
Youngdeok Kim, Angela Lumpkin, Marc Lochbaum, Steven Stegemeier, Karla Kitten
This study examined the effects of utilizing a wearable activity tracker in a credit-based physical activity instructional program (PAIP) for promoting physical activity (PA) in college students. Fourteen PAIP courses in a large public university were randomly assigned into intervention (k = 7; n = 101) and control (k = 7; n = 86) groups. All courses focused on a core curriculum that covers basic exercise and behavioral science contents through lectures and activity sessions. A Misfit Flash activity tracker was provided to students in the intervention group...
January 10, 2018: Journal of Sports Sciences
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