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https://www.readbyqxmd.com/read/29334664/methyl-dehydroabietate-counters-high-fat-diet-induced-insulin-resistance-and-hepatic-steatosis-by-modulating-peroxisome-proliferator-activated-receptor-signaling-in-mice
#1
Hiroki Yoshioka, Yuki Mizuno, Tomohiro Yamaguchi, Yoshimi Ichimaru, Koichi Takeya, Yukio Hitotsuyanagi, Tsunemasa Nonogaki, Yutaka Aoyagi
The aim of this study was to investigate the therapeutic effects of methyl dehydroabietate (mDA) on adipocyte differentiation in 3T3-L1 preadipocytes and obesity characteristics induced by high-fat diet (HFD) in mice. Adipocyte differentiation in 3T3-L1 cells was evaluated after 14 days of incubation with mDA. mDA enhanced adipocyte differentiation in 3T3-L1 cells. For the in vivo evaluation, five-week-old male C57BL/6J mice were fed HFD or normal CE-2 diet (control) for eight weeks. During the experimental period, mice were administered mDA (50 mg/kg, p...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29332796/direct-olive-oil-analysis-by-mass-spectrometry-a-comparison-of-different-ambient-ionization-methods
#2
Felipe J Lara-Ortega, Miriam Beneito-Cambra, José Robles-Molina, Juan F García-Reyes, Bienvenida Gilbert-López, Antonio Molina-Díaz
Analytical methods based on ambient ionization mass spectrometry (AIMS) combine the classic outstanding performance of mass spectrometry in terms of sensitivity and selectivity along with convenient features related to the lack of sample workup required. In this work, the performance of different mass spectrometry-based methods has been assessed for the direct analyses of virgin olive oil for quality purposes. Two sets of experiments have been setup: (1) direct analysis of untreated olive oil using AIMS methods such as Low-Temperature Plasma Mass Spectrometry (LTP-MS) or paper spray mass spectrometry (PS-MS); or alternatively (2) the use of atmospheric pressure ionization (API) mass spectrometry by direct infusion of a diluted sample through either atmospheric pressure chemical ionization (APCI) or electrospray (ESI) ionization sources...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29330573/tocotrienol-supplementation-suppressed-bone-resorption-and-oxidative-stress-in-postmenopausal-osteopenic-women-a-12-week-randomized-double-blinded-placebo-controlled-trial
#3
C-L Shen, S Yang, M D Tomison, A W Romero, C K Felton, H Mo
Tocotrienols have shown bone-protective effect in animals. This study showed that a 12-week tocotrienol supplementation decreased concentrations of bone resorption biomarker and bone remodeling regulators via suppressing oxidative stress in postmenopausal osteopenic women. INTRODUCTION: Tocotrienols (TT) have been shown to benefit bone health in ovariectomized animals, a model of postmenopausal women. The purpose of this study was to evaluate the effect of 12-week TT supplementation on bone markers (serum bone-specific alkaline phosphatase (BALP), urine N-terminal telopeptide (NTX), serum soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), and serum osteoprotegerin (OPG)), urine calcium, and an oxidative stress biomarker (8-hydroxy-2'-deoxyguanosine (8-OHdG)) in postmenopausal women with osteopenia...
January 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29330461/comparing-olive-oil-and-c4-dietary-oil-a-prodrug-for-the-gpr119-agonist-2-oleoyl-glycerol-less-energy-intake-of-the-latter-is-needed-to-stimulate-incretin-hormone-secretion-in-overweight-subjects-with-type-2-diabetes
#4
Mette Johannsen Mandøe, Katrine Bagge Hansen, Johanne Agerlin Windeløv, Filip Krag Knop, Jens Frederik Rehfeld, Mette Marie Rosenkilde, Jens Juul Holst, Harald Severin Hansen
BACKGROUND/OBJECTIVE: After digestion, dietary triacylglycerol stimulates incretin release in humans, mainly through generation of 2-monoacylglycerol, an agonist for the intestinal G protein-coupled receptor 119 (GPR119). Enhanced incretin release may have beneficial metabolic effects. However, dietary fat may promote weight gain and should therefore be restricted in obesity. We designed C4-dietary oil (1,3-di-butyryl-2-oleoyl glycerol) as a 2-oleoyl glycerol (2-OG)-generating fat type, which would stimulate incretin release to the same extent while providing less calories than equimolar amounts of common triglycerides, e...
January 12, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29329876/discrimination-of-processing-grades-of-olive-oil-and-other-vegetable-oils-by-monochloropropanediol-esters-and-glycidyl-esters
#5
Jing Yan, Sergio B Oey, Stefan P J van Leeuwen, Saskia M van Ruth
In this study, the processing derived contaminants 2- and 3-monochloropropanediol (2- and 3-MCPD) esters and glycidyl esters (GEs) were analysed in 84 oil samples by GC-MS/MS for the discrimination of processing grades of olive oils as a potential authentication tool. Concentrations of 2- and 3-MCPD esters and GEs varied in the ranges 0-6 mg/kg, 0-1.5 mg/kg, and 0-1 mg/kg oil, respectively. The concentrations of the three compounds in lower grade olive oils were significantly higher (P < .001) than that in EVOO...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329836/fermented-apulian-table-olives-effect-of-selected-microbial-starters-on-polyphenols-composition-antioxidant-activities-and-bioaccessibility
#6
Isabella D'Antuono, Angelica Bruno, Vito Linsalata, Fiorenza Minervini, Antonella Garbetta, Maria Tufariello, Giovanni Mita, Antonio F Logrieco, Gianluca Bleve, Angela Cardinali
The effects of fermentation by autochthonous microbial starters on phenolics composition of Apulian table olives, Bella di Cerignola (BDC), Termite di Bitetto (TDB) and Cellina di Nardò (CEL) were studied, highlighting also the cultivars influence. In BDC with starter, polyphenols amount doubled compared with commercial sample, while in TDB and CEL, phenolics remain almost unchanged. The main phenolics were hydroxytyrosol, tyrosol, verbascoside and luteolin, followed by hydroxytyrosol-acetate detected in BDC and cyanidine-3-glucoside and quercetin in CEL...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329810/facile-microencapsulation-of-olive-oil-in-porous-starch-granules-fabrication-characterization-and-oxidative-stability
#7
Miao Lei, Fang-Cheng Jiang, Jie Cai, Si Hu, Rui Zhou, Gang Liu, Yue-Hui Wang, Hai-Bo Wang, Jing-Ren He, Xin-Gao Xiong
In this study, starch with porous structures derived from purple sweet potato was prepared and used as a food-grade polymer for the microencapsulation of olive oil. The optimal reaction conditions for preparing porous starch were determined to improve its adsorption capacity as effective microcapsule-wall materials. Olive oil was then impregnated in microspheres, and loading ratio was optimized by investigating the restrictive factors, including the mass ratio of olive oil to porous starch, as well as the embedding temperature and time...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329806/effect-of-different-animal-fat-and-plant-oil-additives-on-physicochemical-mechanical-antimicrobial-and-antioxidant-properties-of-chitosan-films
#8
Lalehan Akyuz, Murat Kaya, Sedef Ilk, Yavuz Selim Cakmak, Asier M Salaberria, Jalel Labidi, Bahar Akyuz Yılmaz, Idris Sargin
Practical application of chitosan-essential oil blend films is limited due to the uneconomical extraction procedure of essential oils from plants. This study aimed to produce chitosan films blended with low cost and commercially available oils and fats consumed in daily human diet (olive, corn and sunflower oils, butter and animal fats). The study also focused on how physicochemical, biological and mechanical properties of chitosan blend films were influenced by the incorporation of oils and fats with varying unsaturation degrees...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329427/ozone-induced-vascular-contractility-and-pulmonary-injury-are-differentially-impacted-by-diets-enriched-with-coconut-oil-fish-oil-and-olive-oil
#9
Samantha J Snow, Wan-Yun Cheng, Andres Henriquez, Myles Hodge, Virgina Bass, Gail M Nelson, Gleta Carswell, Judy E Richards, Mette C Schladweiler, Allen D Ledbetter, Brian Chorley, Kymberly M Gowdy, Haiyan Tong, Urmila P Kodavanti
Fish, olive, and coconut oil dietary supplementation have several cardioprotective benefits, but it is not established if they protect against air pollution-induced adverse effects. We hypothesized that these dietary supplements would attenuate ozone-induced systemic and pulmonary effects. Male Wistar Kyoto rats were fed either a normal diet, or a diet supplemented with fish, olive, or coconut oil for 8 weeks. Animals were then exposed to air or ozone (0.8 ppm), 4h/day for 2 days. Ozone exposure increased phenylephrine-induced aortic vasocontraction, which was completely abolished in rats fed the fish oil diet...
January 10, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29317884/evaluation-of-the-anti-schistosomal-effects-of-turmeric-curcuma-longa-versus-praziquantel-in-schistosoma-mansoni-infected-mice
#10
Atef Hussein, Samia Rashed, Ibrahim El Hayawan, Rabab El-Sayed, Hemat Ali
Background: Curcumin is the major active ingredient of Curcuma longa L., traditionally known as turmeric and has been shown to exhibit a wide range of pharmacological activities including anti-parasitic effect. However, it is found to be water-insoluble and has low bioavailability. The aim of this study was to explore the potential role of turmeric solved in olive oil either alone or in combination with praziquantel (PZQ) in treatment of schistosomiasis mansoni. Methods: The whole turmeric powder suspended in olive oil (as a solvent) is indicated to S...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29317226/oral-delivery-of-highly-lipophilic-poorly-water-soluble-drugs-self-emulsifying-drug-delivery-systems-sedds-to-improve-oral-absorption-and-enable-high-dose-toxicology-studies-of-a-cetp-inhibitor-in-preclinical-species
#11
Xue-Qing Chen, Theresa Ziemba, Christine Huang, Ming Chang, Carrie Xu, Jennifer X Qiao, Tammy C Wang, Heather J Finlay, Mark E Salvati, Leonard P Adam, Olafur Gudmundsson, Michael J Hageman
BMS-A is a highly lipophilic compound (clogP 10.5) with poor aqueous solubility (< 0.0001 mg/mL at pH 6.5). The compound exhibits low oral exposure when dosed as cosolvent solution formulations. The purpose of this study was to evaluate lipid-based formulations for enabling high-dose toxicology studies and enhancing toxicology margins of BMS-A in pre-GLP studies in non-rodent species. The solubility of BMS-A was screened in lipid and cosolvent/surfactant excipients and prototype formulations were developed...
January 6, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29310011/antioxidant-capacity-insecticidal-ability-and-heat-oxidation-stability-of-tagetes-lemmonii-leaf-extract
#12
Chih-Ming Ma, Chih-Lun Cheng, Shang-Chieh Lee, Gui-Bing Hong
The aim of this study was to examine the effect of process factors such as ethanol concentration, extraction time and temperature on the extraction yield and the bioactive contents of Tagetes lemmonii leaf extracts using response surface methodology (RSM). ANOVA results showed that the response variables were affected by the ethanol concentration to a very significant degree and by extraction temperature to a lesser degree. GC/MS characterization showed that the extract is rich in bioactive compounds and those present exhibited important biological activities such as antioxidant, insect repellence and insecticidal activities...
January 5, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29307343/hepatoprotective-properties-for-salvia-cryptantha-extract-on-carbon-tetrachloride-induced-liver-injury
#13
Alper Yalcin, Onder Yumrutas, Tuncay Kuloglu, Ebru Elibol, Ali Parlar, İsmet Yilmaz, Mustafa Pehlivan, Mevlut Dogukan, Fatih Uckardes, Hasan Aydin, Ahmet Turk, Oznur Uludag, İbrahim Sahin, Kader Ugur, Suleyman Aydin
The present study was designed to determine the possible hepatoprotective effects of Salvia cryptantha (black weed) plant extract against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Animals were grouped as follows: control group (Group I), CCl4 group (Group II), olive oil group (Group III), CCl4 + S. cryphantha 200 mg/kg group (Group IV), and CCl4 + S. cryptantha 400mg/kg group (Group V). Rats were injected intraperitoneally with CCl4 diluted in olive oil (50% v/v) at a dose of 1ml/kg body weight...
December 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29306619/comparative-study-between-conventional-fasting-versus-overnight-infusion-of-lipid-or-carbohydrate-on-insulin-and-free-fatty-acids-in-obese-patients-undergoing-elective-on-pump-coronary-artery-bypass-grafting-a-prospective-randomized-trial
#14
Hisham Hosny, Mohamed Ibrahim, Wael El-Siory, Amr Abdel-Monem
OBJECTIVES: Postoperative insulin resistance represents a major component of postoperative metabolic disorder. The authors compared the effects of preoperative infusion of lipid emulsion or carbohydrate to conventional preoperative fasting on postoperative insulin and free fatty acid (FFA) levels. DESIGN: A prospective randomized double-blinded study. SETTINGS: Tertiary university hospital. PARTICIPANTS: Sixty-three patients undergoing coronary artery bypass grafting...
November 24, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29306143/arsenic-adsorption-and-plant-availability-in-an-agricultural-soil-irrigated-with-as-rich-water-effects-of-fe-rich-amendments-and-organic-and-inorganic-fertilisers
#15
Elena Arco-Lázaro, Tania Pardo, Rafael Clemente, Ma Pilar Bernal
The use of As-rich water for irrigation in agricultural soils may result in As accumulation in soil and crops, with the consequent risk of its entry into the food chain. The effectiveness of three different Fe-based materials (a commercial iron oxide (Bayoxide®), lamination slag (a by-product of the hot rolling of steel) and a commercial red mud derivative (ViroBind™)) used as soil amendments to minimise the impact of irrigation with As-rich water in an agricultural soil-plant system was evaluated in a pot experiment...
January 3, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29304744/a-randomised-controlled-intervention-study-investigating-the-efficacy-of-carotenoid-rich-fruits-and-vegetables-and-extra-virgin-olive-oil-on-attenuating-sarcopenic-symptomology-in-overweight-and-obese-older-adults-during-energy-intake-restriction-protocol-paper
#16
Anthony Villani, Hattie Wright, Gary Slater, Jonathan Buckley
BACKGROUND: Weight loss interventions have not been advocated for overweight/obese older adults due to potential loss of skeletal muscle and strength impacting on physical function with potential loss of independence. Carotenoids and polyphenols are inversely associated with sarcopenic symptomology. This paper reports the protocol of a study evaluating the efficacy of a high-protein, energy restricted diet rich in carotenoids and polyphenols on body composition, muscle strength, physical performance and quality of life in overweight and obese older adults...
January 5, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29300425/aging-and-adherence-to-the-mediterranean-diet-relationship-with-cardiometabolic-disorders-and-polypharmacy
#17
R Vicinanza, G Troisi, R Cangemi, M Ulderico De Martino, D Pastori, S Bernardini, F Crisciotti, F Di Violante, A Frizza, M Cacciafesta, P Pignatelli, V Marigliano
OBJECTIVES: To investigate the association between adherence to the Mediterranean Diet (Med-Diet), cardiometabolic disorders and polypharmacy. DESIGN: Cross-sectional study. SETTING: Geriatrics outpatient clinic, Policlinico Umberto I, Sapienza University of Rome. PARTICIPANTS: 508 patients (219 male, 289 female) aged 50 to 89 who were evaluated for cardiovascular and metabolic disorders. METHODS AND MEASUREMENTS: Patients underwent a comprehensive medical assessment including medical history and the use of medications...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29299572/phenolic-profiles-of-eight-olive-cultivars-from-algeria-effect-of-bactrocera-oleae-attack
#18
Lynda Medjkouh, Abderezak Tamendjari, Rita C Alves, Rahima Laribi, M Beatriz P P Oliveira
Olive fly (Bactrocera oleae R.) is the most harmful pest of olive trees (O. europaea) affecting their fruit development and oil production. Olive fruits have characteristic phenolic compounds, important for plant defense against pathogens and insects, and with many biological activities, they contribute to the high value of this crop. In this study, olives from 8 cultivars (Abani, Aellah, Blanquette de Guelma, Chemlal, Ferkani, Limli, Rougette de Mitidja and Souidi) with different degrees of fly infestation (0%, not attacked; 100%, all attacked; and real attack %) and different maturation indices were sampled and analysed...
January 4, 2018: Food & Function
https://www.readbyqxmd.com/read/29295516/impact-of-consuming-extra-virgin-olive-oil-or-nuts-within-a-mediterranean-diet-on-dna-methylation-in-peripheral-white-blood-cells-within-the-predimed-navarra-randomized-controlled-trial-a-role-for-dietary-lipids
#19
Ana Arpón, Fermín I Milagro, Cristina Razquin, Dolores Corella, Ramón Estruch, Montserrat Fitó, Amelia Marti, Miguel A Martínez-González, Emilio Ros, Jordi Salas-Salvadó, José-Ignacio Riezu-Boj, J Alfredo Martínez
DNA methylation could be reversible and mouldable by environmental factors, such as dietary exposures. The objective was to analyse whether an intervention with two Mediterranean diets, one rich in extra-virgin olive oil (MedDiet + EVOO) and the other one in nuts (MedDiet + nuts), was influencing the methylation status of peripheral white blood cells (PWBCs) genes. A subset of 36 representative individuals were selected within the PREvención con DIeta MEDiterránea (PREDIMED-Navarra) trial, with three intervention groups in high cardiovascular risk volunteers: MedDiet + EVOO, MedDiet + nuts, and a low-fat control group...
December 23, 2017: Nutrients
https://www.readbyqxmd.com/read/29289766/treatment-of-olive-oil-mill-wastewater-by-single-electrocoagulation-with-different-electrodes-and-sequential-electrocoagulation-electrochemical-fenton-based-processes
#20
Nelly Flores, Enric Brillas, Francesc Centellas, Rosa María Rodríguez, Pere Lluís Cabot, José Antonio Garrido, Ignasi Sirés
The treatment of olive oil mill wastewater (OOMW) by novel sequential processes involving electrocoagulation (EC) followed by electro-Fenton (EF) or photoelectro-Fenton (PEF) under UVA irradiation has been studied using a boron-doped diamond anode and an air-diffusion cathode for H2O2 electrogeneration. Their performance was monitored from the removal of total organic carbon (TOC), chemical oxygen demand, turbidity, total solids and total nitrogen, as well as from the energy consumption. Preliminary EC assays were performed with one pair of electrodes made of Al, Fe, AISI 304 or AISI 316L...
December 24, 2017: Journal of Hazardous Materials
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