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https://www.readbyqxmd.com/read/28807819/carrier-characteristics-influence-the-kinetics-of-passive-drug-loading-into-lipid-nanoemulsions
#1
Katrin Göke, Heike Bunjes
Passive loading as a novel screening approach is a material-saving tool for the efficient selection of a suitable colloidal lipid carrier system for poorly water soluble drug candidates. This method comprises incubation of preformed carrier systems with drug powder and subsequent determination of the resulting drug load of the carrier particles after removal of excess drug. For reliable routine use and to obtain meaningful loading results, information on the kinetics of the process is required. Passive loading proceeds via a dissolution-diffusion-based mechanism, where drug surface area and drug water solubility are key parameters for fast passive loading...
August 12, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28789606/-pharming-out-support-a-promising-approach-to-integrating-clinical-pharmacists-into-established-primary-care-medical-home-practices
#2
Kimberly D Brunisholz, Jeff Olson, Jonathan W Anderson, Emily Hays, Peggy M Tilbury, Bradley Winter, Josh Rickard, Sharon Hamilton, Gregory Parkin
Objective Embedding clinical pharmacists into ambulatory care settings needs to be assessed in the context of established medical home models. Methods A retrospective, observational study examined the effectiveness of the Intermountain Healthcare Collaborative Pharmacist Support Services (CPSS) program from 2012-2015 among adult patients diagnosed with diabetes mellitus (DM) and/or high blood pressure (HBP). Patients who attended this program were considered the intervention (CPSS) cohort. These patients were matched using propensity scores with a reference group (no-CPSS cohort) to determine the effect of achieving disease management goals and time to achievement...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28669783/gabaergic-signaling-within-the-basolateral-amygdala-complex-modulates-resistance-to-the-labilization-reconsolidation-process
#3
Pablo Javier Espejo, Vanesa Ortiz, Irene Delia Martijena, Victor Alejandro Molina
It is well known that stress can affect mnemonic processes. In particular, stress before contextual fear conditioning induces a memory which exhibits resistance to being interfered with by Midazolam (MDZ) when applied after memory retrieval. Moreover, stress exposure strongly affects GABAergic transmission within the Basolateral Amygdala Complex (BLA), a brain structure critically involved in fear memory processing. The present study evaluated the involvement of GABAergic signaling within the BLA on the induction of resistance to memory reconsolidation interference...
June 29, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28590834/comparison-of-the-effects-of-a-pharmaceutical-industry-decision-guide-and-decision-aids-on-patient-choice-to-intensify-therapy-in-rheumatoid-arthritis
#4
Richard W Martin, Ryan D Enck, Donald J Tellinghuisen, Aaron T Eggebeen, James D Birmingham, Andrew J Head
OBJECTIVE: To compare the effects a pharmaceutical industry decision guide and International Patient Decision Aids Standard (IPDAS) compliant patient decision aids (PtDA) on patient medication beliefs and choice to intensify therapy. METHODS: Rheumatoid arthritis (RA) patients, who had never taken etanercept (Enbrel), took part in a mail survey. They were presented with a hypothetical decision scenario where they were asked to consider adding etanercept to their current regimen...
July 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28471102/cycloplegic-refraction-in-hyperopic-children-effectiveness-of-a-0-5-tropicamide-and-0-5-phenylephrine-addition-to-1-cyclopentolate-regimen
#5
Seul Gi Yoo, Myung Jin Cho, Ungsoo Samuel Kim, Seung Hee Baek
PURPOSE: To evaluate the effectiveness of a cycloplegic regimen using 0.5% tropicamide and 0.5% phenylephrine (Tropherine, Hanmi Pharm), in addition to 1% cyclopentolate, in hyperopic children. METHODS: The medical records of hyperopic patients below the age of 14 years who had undergone cycloplegic retinoscopy were retrospectively reviewed. Cycloplegic refractions were performed using one of two cycloplegic regimens. Regimen 1 was a Tropherine-added regimen comprising the administration of one drop of 1% cyclopentolate followed by two to three drops of Tropherine added at 15-minute intervals...
June 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28285172/multifunctional-luv-liposomes-decorated-for-bbb-and-amyloid-targeting-b-in-vivo-brain-targeting-potential-in-wild-type-and-app-ps1-mice
#6
Konstantina Papadia, Anastasios D Giannou, Eleni Markoutsa, Christian Bigot, Greejte Vanhoute, Spyridon Mourtas, Annemie Van der Linded, Georgios T Stathopoulos, Sophia G Antimisiaris
Multifunctional liposomes (mf-LIPs) having a curcumin-lipid ligand (to target amyloids) together with two ligands to target the transferrin, and the low-density apolipoprotein receptor of the blood-brain-barrier (BBB) on their surface, were previously studied (in vitro) as potential theranostic systems for Alzheimer's disease (AD) (Papadia et al., 2017, Eur. J. Pharm. Sciences; 101:140-148). Herein, the targeting potential of mf-LIPs was compared to that of BBB-LIPs (liposomes having only the two BBB-specific ligands) in FVB mice (normal), as well as in double transgenic mice (APP/PS1) and their corresponding littermates (WT), by live-animal (in vivo) and explanted organ (ex vivo) imaging...
March 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28109583/detection-of-recombinant-human-lactoferrin-and-lysozyme-produced-in-a-bitransgenic-cow
#7
Germán G Kaiser, Nicolás C Mucci, Vega González, Lourdes Sánchez, José A Parrón, María D Pérez, Miguel Calvo, Juan F Aller, Federico A Hozbor, Adrián A Mutto
Lactoferrin and lysozyme are 2 glycoproteins with great antimicrobial activity, being part of the nonspecific defensive system of human milk, though their use in commercial products is difficult because human milk is a limited source. Therefore, many investigations have been carried out to produce those proteins in biological systems, such as bacteria, yeasts, or plants. Mammals seem to be more suitable as expression systems for human proteins, however, especially for those that are glycosylated. In the present study, we developed a bicistronic commercial vector containing a goat β-casein promoter and an internal ribosome entry site fragment between the human lactoferrin and human lysozyme genes to allow the introduction of both genes into bovine adult fibroblasts in a single transfection...
March 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28075490/soluble-transferrin-receptor-and-risk-of-type-2-diabetes-in-the-obese-and-nonobese
#8
José C Fernández-Cao, Victoria Arija, Núria Aranda, Josep Basora, Javier Diez-Espino, Ramón Estruch, Montse Fitó, Dolores Corella, Jordi Salas-Salvadó
BACKGROUND: Studies evaluating the relationship between soluble transferrin receptor (sTfR), a biomarker inversely related to body iron stores, and risk of type 2 diabetes mellitus (T2DM) are scarce and inconclusive. Furthermore, sTfR concentrations have been observed to be significantly higher in obese than in nonobese individuals. Therefore, the aim of this study was to assess the relationship between sTfR and the risk of T2DM in obese and nonobese subjects. DESIGN: A nested case-control study of 153 cases of newly diagnosed diabetic subjects, 73 obese and 80 nonobese, and 306 individually matched controls, 138 obese and 166 nonobese, who did not develop T2DM for a median 6-year follow-up (interquartile range: 3·9-6·5) was conducted using data from the PREvention with MEDiterranean Diet (PREDIMED) cohort (http://www...
March 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27909544/reducing-the-risk-of-stroke-in-patients-with-nonvalvular-atrial-fibrillation-with-direct-oral-anticoagulants-is-one-of-these-not-like-the-others
#9
REVIEW
Paul P Dobesh, John Fanikos
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and increases risk of stroke by nearly 5-fold. While warfarin has been employed successfully to reduce the risk of stroke in these patients, there are a number of challenges with therapy. These include the need for therapeutic monitoring due to variability in patient response, frequent dose adjustments, numerous drug-drug, drug-food, and drug-disease interactions, and a heightened risk of thrombosis and bleeding due to these issues. Current guidelines recommend that the vitamin K antagonists (VKA) or direct oral anticoagulants (DOACs) should be used for thromboprophylaxis in patients with nonvalvular AF at risk for stroke or systemic embolic events...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27885711/the-importance-of-research-and-scholarly-activity-in-pharmacy-training
#10
Eli N Deal, Paul M Stranges, Whitney D Maxwell, Jennifer Bacci, Emily J Ashjian, David L DeRemer, Sandra L Kane-Gill, Nicholas B Norgard, Lauren Dombrowski, Robert B Parker
Regardless of practice setting, it is imperative that pharmacists be able to either participate in generating new knowledge or use the ever-expanding body of literature to guide patient care. However, competing priorities in Pharm.D. curricula and residency training programs have resulted in limited emphasis on acquiring research and scholarly skills. Factors likely contributing to this reduced focus include the lack of curricular and postgraduate training standards emphasizing the development of research skills, time to commit to scholarly activity, and accessibility to experienced mentors...
December 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27864206/educational-strategies-to-enable-expansion-of-pharmacogenomics-based-care
#11
Kristin Wiisanen Weitzel, Christina L Aquilante, Samuel Johnson, David F Kisor, Philip E Empey
PURPOSE: The current state of pharmacogenomics education for pharmacy students and practitioners is discussed, and resources and strategies to address persistent challenges in this area are reviewed. SUMMARY: Consensus-based pharmacist competencies and guidelines have been published to guide pharmacogenomics knowledge attainment and application in clinical practice. Pharmacogenomics education is integrated into various pharmacy school courses and, increasingly, into Pharm...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27846806/gen3va-aggregation-and-analysis-of-gene-expression-signatures-from-related-studies
#12
Gregory W Gundersen, Kathleen M Jagodnik, Holly Woodland, Nicholas F Fernandez, Kevin Sani, Anders B Dohlman, Peter Man-Un Ung, Caroline D Monteiro, Avner Schlessinger, Avi Ma'ayan
BACKGROUND: Genome-wide gene expression profiling of mammalian cells is becoming a staple of many published biomedical and biological research studies. Such data is deposited into data repositories such as the Gene Expression Omnibus (GEO) for potential reuse. However, these repositories currently do not provide simple interfaces to systematically analyze collections of related studies. RESULTS: Here we present GENE Expression and Enrichment Vector Analyzer (GEN3VA), a web-based system that enables the integrative analysis of aggregated collections of tagged gene expression signatures identified and extracted from GEO...
November 15, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27374120/the-harmonizome-a-collection-of-processed-datasets-gathered-to-serve-and-mine-knowledge-about-genes-and-proteins
#13
Andrew D Rouillard, Gregory W Gundersen, Nicolas F Fernandez, Zichen Wang, Caroline D Monteiro, Michael G McDermott, Avi Ma'ayan
Genomics, epigenomics, transcriptomics, proteomics and metabolomics efforts rapidly generate a plethora of data on the activity and levels of biomolecules within mammalian cells. At the same time, curation projects that organize knowledge from the biomedical literature into online databases are expanding. Hence, there is a wealth of information about genes, proteins and their associations, with an urgent need for data integration to achieve better knowledge extraction and data reuse. For this purpose, we developed the Harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins from over 70 major online resources...
2016: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/27323898/erratum
#14
(no author information available yet)
Corrigendum to Manuscript "Pfeifer T, Buchebner M, Chandak PG, Patankar J, Kratzer A, Obrowsky S, Rechberger GN, Kadam RS, Kompella UB, Kostner GM, Kratky D, Levak-Frank S. Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol. Curr Pharm Biotechnol. 2011 Feb 1;12(2):285-92." LC-MS internal standard peak areas used in the calculation of brain DMHCA levels in the original manuscript were in error. Brain tissue levels were recalculated using valid internal standard peak areas and the revised Figure 6C is presented below...
2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27141961/enrichr-a-comprehensive-gene-set-enrichment-analysis-web-server-2016-update
#15
Maxim V Kuleshov, Matthew R Jones, Andrew D Rouillard, Nicolas F Fernandez, Qiaonan Duan, Zichen Wang, Simon Koplev, Sherry L Jenkins, Kathleen M Jagodnik, Alexander Lachmann, Michael G McDermott, Caroline D Monteiro, Gregory W Gundersen, Avi Ma'ayan
Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams...
July 8, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27117185/a-conceptual-framework-toward-identifying-and-analyzing-challenges-to-the-advancement-of-pharmacy
#16
Lina R Bader, Simon McGrath, Michael J Rouse, Claire Anderson
BACKGROUND: Pharmacists and health care professionals are faced with increasing and changing health care needs around the world. To meet these demands, they are required to continuously upgrade and develop their professions. Reprofessionalization is therefore crucial to the successful delivery of health services, but traditional theories might provide little practical guidance to evaluating the overall status of a profession. OBJECTIVE: This study proposes a new conceptual framework of three interrelated professional sectors: education, regulation and practice, and uses it to identify and analyze challenges facing the pharmacy profession in Jordan...
March 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27097635/the-use-of-cellulose-membrane-to-eliminate-burst-release-from-intravaginal-rings
#17
COMMENT
Ignacio M Helbling, Juan C D Ibarra, Julio A Luna
Burst release was observed when ethylene vinyl acetate copolymer (EVA) intravaginal rings were tested for progesterone release in our previous work (Helbling et al. Pharm Res. 31(3):795-808, 2014). Burst release is undesirable in controlled delivery devices because release is uncontrollable and higher levels of active pharmaceutical ingredient could lead to the occurrence of adverse effect. The present contribution is about the use of membranes to coat EVA rings to eliminate burst release. Physicochemical state of progesterone in uncoated rings and the solubility and diffusion coefficient in membrane were studied...
2016: AAPS Journal
https://www.readbyqxmd.com/read/27013918/corrigendum-to-medication-safety-practices-in-hospitals-a-national-survey-in-saudi-arabia-saudi-pharm-j-21-2-2013-159-164
#18
Hisham Aljadhey, Abdulaziz Alhossan, Khalid Alburikan, Mansour Adam, Michael D Murray, David W Bates
[This corrects the article DOI: 10.1016/j.jsps.2012.07.005.].
March 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/26932303/high-prevalence-of-self-medication-practices-among-medical-and-pharmacy-students-a-study-from-jordan
#19
COMPARATIVE STUDY
Mohammad J Alkhatatbeh, Qais Alefan, Mohammad A Y Alqudah
OBJECTIVE: To assess self-medication practices and to evaluate the impact of obtaining medical knowledge on self-medication among medical and pharmacy students at Jordan University of Science and Technology. METHODS: This was a cross-sectional study. A well-validated questionnaire that included 3 sections about self-medication was administered to the subjects after introducing the term "self-medication" verbally. RESULTS: 1,317 students had participated in the study and were subgrouped according to their academic level into seniors and juniors...
May 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26798374/factors-associated-with-pharmacists-perceptions-of-their-working-conditions-and-safety-and-effectiveness-of-patient-care
#20
Nicole W Tsao, Larry D Lynd, Louise Gastonguay, Kathy Li, Bob Nakagawa, Carlo A Marra
BACKGROUND: In recent years, the role of pharmacists has changed, as have various provincial legislations, which now allow pharmacists to provide additional health services to patients. With these changes comes growing concern about how well the current pharmacy working environment is adapting and whether it may also be creating work-related stress that may contribute to potentially unsafe practices of patient care. METHODS: To characterize the current working conditions of pharmacists in British Columbia, an online survey was developed and distributed to all College of Pharmacists of BC (CPBC) registrants by email...
January 2016: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
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