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https://www.readbyqxmd.com/read/27909544/reducing-the-risk-of-stroke-in-patients-with-nonvalvular-atrial-fibrillation-with-direct-oral-anticoagulants-is-one-of-these-not-like-the-others
#1
REVIEW
Paul P Dobesh Pharm D, John Fanikos Mba R Ph
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and increases risk of stroke by nearly 5-fold. While warfarin has been employed successfully to reduce the risk of stroke in these patients, there are a number of challenges with therapy. These include the need for therapeutic monitoring due to variability in patient response, frequent dose adjustments, numerous drug-drug, drug-food, and drug-disease interactions, and a heightened risk of thrombosis and bleeding due to these issues. Current guidelines recommend that the vitamin K antagonists (VKA) or direct oral anticoagulants (DOACs) should be used for thromboprophylaxis in patients with nonvalvular AF at risk for stroke or systemic embolic events...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27885711/the-importance-of-research-and-scholarly-activity-in-pharmacy-training
#2
Eli N Deal, Paul M Stranges, Whitney D Maxwell, Jennifer Bacci, Emily J Ashjian, David L DeRemer, Sandra L Kane-Gill, Nicholas B Norgard, Lauren Dombrowski, Robert B Parker
Regardless of practice setting, it is imperative that pharmacists be able to either participate in generating new knowledge or use the ever-expanding body of literature to guide patient care. However, competing priorities in Pharm.D. curricula and residency training programs have resulted in limited emphasis on acquiring research and scholarly skills. Factors likely contributing to this reduced focus include the lack of curricular and postgraduate training standards emphasizing the development of research skills, time to commit to scholarly activity, and accessibility to experienced mentors...
November 25, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27864206/educational-strategies-to-enable-expansion-of-pharmacogenomics-based-care
#3
Kristin Wiisanen Weitzel, Christina L Aquilante, Samuel Johnson, David F Kisor, Philip E Empey
PURPOSE: The current state of pharmacogenomics education for pharmacy students and practitioners is discussed, and resources and strategies to address persistent challenges in this area are reviewed. SUMMARY: Consensus-based pharmacist competencies and guidelines have been published to guide pharmacogenomics knowledge attainment and application in clinical practice. Pharmacogenomics education is integrated into various pharmacy school courses and, increasingly, into Pharm...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27846806/gen3va-aggregation-and-analysis-of-gene-expression-signatures-from-related-studies
#4
Gregory W Gundersen, Kathleen M Jagodnik, Holly Woodland, Nicholas F Fernandez, Kevin Sani, Anders B Dohlman, Peter Man-Un Ung, Caroline D Monteiro, Avner Schlessinger, Avi Ma'ayan
BACKGROUND: Genome-wide gene expression profiling of mammalian cells is becoming a staple of many published biomedical and biological research studies. Such data is deposited into data repositories such as the Gene Expression Omnibus (GEO) for potential reuse. However, these repositories currently do not provide simple interfaces to systematically analyze collections of related studies. RESULTS: Here we present GENE Expression and Enrichment Vector Analyzer (GEN3VA), a web-based system that enables the integrative analysis of aggregated collections of tagged gene expression signatures identified and extracted from GEO...
November 15, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27374120/the-harmonizome-a-collection-of-processed-datasets-gathered-to-serve-and-mine-knowledge-about-genes-and-proteins
#5
Andrew D Rouillard, Gregory W Gundersen, Nicolas F Fernandez, Zichen Wang, Caroline D Monteiro, Michael G McDermott, Avi Ma'ayan
Genomics, epigenomics, transcriptomics, proteomics and metabolomics efforts rapidly generate a plethora of data on the activity and levels of biomolecules within mammalian cells. At the same time, curation projects that organize knowledge from the biomedical literature into online databases are expanding. Hence, there is a wealth of information about genes, proteins and their associations, with an urgent need for data integration to achieve better knowledge extraction and data reuse. For this purpose, we developed the Harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins from over 70 major online resources...
2016: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/27323898/erratum
#6
(no author information available yet)
Corrigendum to Manuscript "Pfeifer T, Buchebner M, Chandak PG, Patankar J, Kratzer A, Obrowsky S, Rechberger GN, Kadam RS, Kompella UB, Kostner GM, Kratky D, Levak-Frank S. Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol. Curr Pharm Biotechnol. 2011 Feb 1;12(2):285-92." LC-MS internal standard peak areas used in the calculation of brain DMHCA levels in the original manuscript were in error. Brain tissue levels were recalculated using valid internal standard peak areas and the revised Figure 6C is presented below...
2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27141961/enrichr-a-comprehensive-gene-set-enrichment-analysis-web-server-2016-update
#7
Maxim V Kuleshov, Matthew R Jones, Andrew D Rouillard, Nicolas F Fernandez, Qiaonan Duan, Zichen Wang, Simon Koplev, Sherry L Jenkins, Kathleen M Jagodnik, Alexander Lachmann, Michael G McDermott, Caroline D Monteiro, Gregory W Gundersen, Avi Ma'ayan
Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams...
July 8, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27117185/a-conceptual-framework-toward-identifying-and-analyzing-challenges-to-the-advancement-of-pharmacy
#8
Lina R Bader, Simon McGrath, Michael J Rouse, Claire Anderson
BACKGROUND: Pharmacists and health care professionals are faced with increasing and changing health care needs around the world. To meet these demands, they are required to continuously upgrade and develop their professions. Reprofessionalization is therefore crucial to the successful delivery of health services, but traditional theories might provide little practical guidance to evaluating the overall status of a profession. OBJECTIVE: This study proposes a new conceptual framework of three interrelated professional sectors: education, regulation and practice, and uses it to identify and analyze challenges facing the pharmacy profession in Jordan...
March 18, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27097635/the-use-of-cellulose-membrane-to-eliminate-burst-release-from-intravaginal-rings
#9
Ignacio M Helbling, Juan C D Ibarra, Julio A Luna
Burst release was observed when ethylene vinyl acetate copolymer (EVA) intravaginal rings were tested for progesterone release in our previous work (Helbling et al. Pharm Res. 31(3):795-808, 2014). Burst release is undesirable in controlled delivery devices because release is uncontrollable and higher levels of active pharmaceutical ingredient could lead to the occurrence of adverse effect. The present contribution is about the use of membranes to coat EVA rings to eliminate burst release. Physicochemical state of progesterone in uncoated rings and the solubility and diffusion coefficient in membrane were studied...
July 2016: AAPS Journal
https://www.readbyqxmd.com/read/27013918/corrigendum-to-medication-safety-practices-in-hospitals-a-national-survey-in-saudi-arabia-saudi-pharm-j-21-2-2013-159-164
#10
Hisham Aljadhey, Abdulaziz Alhossan, Khalid Alburikan, Mansour Adam, Michael D Murray, David W Bates
[This corrects the article DOI: 10.1016/j.jsps.2012.07.005.].
March 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/26932303/high-prevalence-of-self-medication-practices-among-medical-and-pharmacy-students-a-study-from-jordan
#11
COMPARATIVE STUDY
Mohammad J Alkhatatbeh, Qais Alefan, Mohammad A Y Alqudah
OBJECTIVE: To assess self-medication practices and to evaluate the impact of obtaining medical knowledge on self-medication among medical and pharmacy students at Jordan University of Science and Technology. METHODS: This was a cross-sectional study. A well-validated questionnaire that included 3 sections about self-medication was administered to the subjects after introducing the term "self-medication" verbally. RESULTS: 1,317 students had participated in the study and were subgrouped according to their academic level into seniors and juniors...
May 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26798374/factors-associated-with-pharmacists-perceptions-of-their-working-conditions-and-safety-and-effectiveness-of-patient-care
#12
Nicole W Tsao, Larry D Lynd, Louise Gastonguay, Kathy Li, Bob Nakagawa, Carlo A Marra
BACKGROUND: In recent years, the role of pharmacists has changed, as have various provincial legislations, which now allow pharmacists to provide additional health services to patients. With these changes comes growing concern about how well the current pharmacy working environment is adapting and whether it may also be creating work-related stress that may contribute to potentially unsafe practices of patient care. METHODS: To characterize the current working conditions of pharmacists in British Columbia, an online survey was developed and distributed to all College of Pharmacists of BC (CPBC) registrants by email...
January 2016: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/26642689/perception-of-academic-pharmacists-towards-their-role-in-healthcare-system-of-a-developing-country-pakistan-a-quantitative-sight
#13
Sheng Li, Saira Azhar, Ghulam Murtaza, Muhammad Hassham Hassan Bin Asad, Syed Haider Shah, Sabiha Karim, Chenghe Shi
To investigate perception of academic pharmacists towards their role in healthcare system of a developing country, Pakistan, was the aim of this study. The study participants consisted of academic pharmacists from the government and private universities of Pakistan. Study was conducted for a period of three months, from January to March 2011, in Pakistan. Academic pharmacists were informed regarding the aim, objective and nature of the study. Verbal consent was given and execution of the study took place. Main sections of the questionnaire were comprised of series of statements pertaining to pharmacist perception and experience with the pharmacists...
March 2015: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26594125/pharmacist-the-pharmaceutical-industry-and-pharmacy-education-in-saudi-arabia-a-questionnaire-based-study
#14
Ghada Bin Saleh, Naser L Rezk, Laila Laika, Anna Ali, Ashraf El-Metwally
BACKGROUND: In Saudi Arabia there is an estimated need of more than 100,000 pharmacy graduates to cover all present sectors. The shortage of pharmacists has affected many of these sectors especially the pharmaceutical industry. The contribution of Saudi pharmacists to local pharmaceuticals industry would be extremely beneficial and important for shaping the future of the drug industry within the Kingdom. It is not clear whether future Saudi pharmacists are willing to contribute to local pharmaco-industrial fields...
October 2015: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/26432957/heme-oxygenase-1-a-novel-target-for-the-treatment-of-diabetic-complications-focus-on-diabetic-peripheral-neuropathy
#15
REVIEW
Geeta Negi, Vanaja Nakkina, Pallavi Kamble, Shyam S Sharma
Diabetic neuropathy is a complex disorder induced by long standing diabetes. Many signaling pathways and transcription factors have been proposed to be involved in the development and progression of related processes. Years of research points to critical role of oxidative stress, neuroinflammation and apoptosis in the pathogenesis of neuropathy in diabetes. Heme oxygenase-1 (HO-1) is heat-shock protein induced under conditions of different kinds of stress and has been implicated in cellular defense against oxidative stress...
December 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26422758/biophysical-characterization-of-the-type-iii-secretion-system-translocator-proteins-and-the-translocator-proteins-attached-to-bacterium-like-particles
#16
Xiaotong Chen, Shyamal P Choudhari, Prashant Kumar, Ronald T Toth, Jae Hyun Kim, Maarten L Van Roosmalen, Kees Leenhouts, C Russell Middaugh, Wendy L Picking, William D Picking
Diarrhea caused by Shigella, Salmonella, and Yersinia is an important public health problem, but development of safe and effective vaccines against such diseases is challenging. A new antigen delivery platform called bacterium-like particles (BLPs) was explored as a means for delivering protective antigens from the type III secretion systems (T3SS) of these pathogens. BLPs are peptidoglycan skeletons derived from Lactococcus lactis that are safe for newborns and can carry multiple antigens. Hydrophobic T3SS translocator proteins were fused to a peptidoglycan anchor (PA) for BLP attachment...
December 2015: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26398200/protein-aggregation-in-frozen-trehalose-formulations-effects-of-composition-cooling-rate-and-storage-temperature
#17
Brian D Connolly, Lan Le, Thomas W Patapoff, Mary E M Cromwell, Jamie M R Moore, Philippe Lam
This study was designed to assess the effects of cooling rate, storage temperature, and formulation composition on trehalose phase distribution and protein stability in frozen solutions. The data demonstrate that faster cooling rates (>100°C/min) result in trehalose crystallization and protein aggregation as determined by Fourier Transform Near-Infrared (FT-NIR) spectroscopy and size-exclusion chromatography, respectively. Conversely, at slower cooling rates (≤1°C/min), trehalose remains predominantly amorphous and there is no effect on protein stability...
December 2015: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26344572/interspecies-differences-in-the-metabolism-of-a-multiester-prodrug-by-carboxylesterases
#18
Jing Fu, Erik Pacyniak, Marina G D Leed, Matthew P Sadgrove, Lesley Marson, Michael Jay
The pentaethyl ester prodrug of the chelating agent diethylene triamine pentaacetic acid (DTPA) referred to as C2E5 is being developed as an orally bioavailable radionuclide decorporation agent. The predicted human efficacy obtained in these experimental animals is confounded by interspecies variations of metabolism. Therefore, in the present study, carboxylesterase-mediated metabolism of [(14)C]-C2E5 was compared in the S9 intestinal and hepatic fractions of human, dog, and rat and their respective plasma...
February 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26220285/assessment-of-pharmaceutical-powder-flowability-using-shear-cell-based-methods-and-application-of-jenike-s-methodology
#19
Paul D Jager, Tommasina Bramante, Paul E Luner
Jenike's approach to hopper design for a large-scale (3150 L) conical hopper was applied to pharmaceutical powders to evaluate flow issues, such as funnel flow or cohesive arching. Seven grades of microcrystalline cellulose (MCC) and six powder blends were tested. A Schulze Ring Shear Tester measured the flow function, wall friction (using stainless steel coupons with a #2B or #8 finish) and compressibility. Hopper Index (HI, maximum hopper angle required for mass flow) and Arching Index (AI, minimum hopper outlet size to prevent cohesive arch formation) were computed using Mathcad(©) ...
November 2015: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26178805/reducible-poly-oligo-d-arginine-as-an-efficient-carrier-of-the-thymidine-kinase-gene-in-the-intracranial-glioblastoma-animal-model
#20
Hyun Ah Kim, Hyun-Lin Lee, Eunji Choi, Yong-Hee Kim, Minhyung Lee
Gene therapy has been considered as an alternative treatment for glioblastoma therapy. In this study, a glioblastoma-specific suicide gene, pEpo-NI2-SV-TK, was delivered into the intracranial glioblastoma model using reducible poly(oligo-d-arginines) (rPOA). pEpo-NI2-SV-TK has the erythropoietin (Epo) enhancer and the nestin intron 2 (NI2) for glioblastoma specific gene expression. The in vitro studies showed that the rPOA formed stable complexes with pEpo-NI2-SV-TK. In the MTT and TUNEL assays, rPOA showed lower cytotoxicity than polyethylenimine (25 kDa, PEI25k)...
November 2015: Journal of Pharmaceutical Sciences
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