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https://www.readbyqxmd.com/read/28727787/feasibility-of-a-3d-printed-anthropomorphic-patient-specific-head-phantom-for-patient-specific-quality-assurance-of-intensity-modulated-radiotherapy
#1
Ji Woon Yea, Jae Won Park, Sung Kyu Kim, Dong Youn Kim, Jae Gu Kim, Chan Young Seo, Won Hyo Jeong, Man Youl Jeong, Se An Oh
This study evaluated the feasibility of utilizing a 3D-printed anthropomorphic patient-specific head phantom for patient-specific quality assurance (QA) in intensity-modulated radiotherapy (IMRT). Contoured left and right head phantoms were converted from DICOM to STL format. Fused deposition modeling (FDM) was used to construct an anthropomorphic patient-specific head phantom with a 3D printer. An established QA technique and the patient-specific head phantom were used to compare the calculated and measured doses...
2017: PloS One
https://www.readbyqxmd.com/read/28726927/custom-3d-printer-and-resin-for-18-%C3%AE-m-%C3%A3-20-%C3%AE-m-microfluidic-flow-channels
#2
Hua Gong, Bryce P Bickham, Adam T Woolley, Gregory P Nordin
While there is great interest in 3D printing for microfluidic device fabrication, to-date the achieved feature sizes have not been in the truly microfluidic regime (<100 μm). In this paper we demonstrate that a custom digital light processor stereolithographic (DLP-SLA) 3D printer and a specifically-designed, low cost, custom resin can readily achieve flow channel cross sections as small as 18 μm × 20 μm. Our 3D printer has a projected image plane resolution of 7.6 μm and uses a 385 nm LED, which dramatically increases the available selection of UV absorbers for resin formulation compared to 3D printers with 405 nm LEDs...
July 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28724980/handheld-co-axial-bioprinting-application-to-in-situ-surgical-cartilage-repair
#3
Serena Duchi, Carmine Onofrillo, Cathal D O'Connell, Romane Blanchard, Cheryl Augustine, Anita F Quigley, Robert M I Kapsa, Peter Pivonka, Gordon Wallace, Claudia Di Bella, Peter F M Choong
Three-dimensional (3D) bioprinting is driving major innovations in the area of cartilage tissue engineering. Extrusion-based 3D bioprinting necessitates a phase change from a liquid bioink to a semi-solid crosslinked network achieved by a photo-initiated free radical polymerization reaction that is known to be cytotoxic. Therefore, the choice of the photocuring conditions has to be carefully addressed to generate a structure stiff enough to withstand the forces phisiologically applied on articular cartilage, while ensuring adequate cell survival for functional chondral repair...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723908/sorting-cells-by-their-density
#4
Nazila Norouzi, Heran C Bhakta, William H Grover
Sorting cells by their type is an important capability in biological research and medical diagnostics. However, most cell sorting techniques rely on labels or tags, which may have limited availability and specificity. Sorting different cell types by their different physical properties is an attractive alternative to labels because all cells intrinsically have these physical properties. But some physical properties, like cell size, vary significantly from cell to cell within a cell type; this makes it difficult to identify and sort cells based on their sizes alone...
2017: PloS One
https://www.readbyqxmd.com/read/28722489/treatment-of-die-punch-fractures-with-3d-printing-technology
#5
Chunhui Chen, Leyi Cai, Chuanxu Zhang, Jianshun Wang, Xiaoshan Guo, Yifei Zhou
PURPOSE: We evaluated the feasibility, accuracy and effectiveness of applying three-dimensional (3D) printing technology for preoperative planning for die-punch fractures. METHODS: A total of 107 patients who underwent die-punch fracture surgery were enrolled in the study. They were randomly divided into two groups: 52 cases in the 3D model group and 55 cases in the routine group. A 3D digital model of each die-punch fracture was reconstructed in the 3D group. The 3D digital model was imported to a 3D printer to build the full solid model...
July 19, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28719986/three-dimensional-printing-of-surgical-clips-an-in-vitro-pilot-study-and-trial-of-efficacy
#6
Noah E Canvasser, Shuvro De, Ersin Koseoglu, Aaron H Lay, Igor Sorokin, Raul Fernandez, Jeffrey A Cadeddu
Introduction and Objective Three-dimensional printing applications have increased over the past decade. Our objective was to test rapid prototyping of a 3D printed surgical clip for intraoperative use. Methods Our prototype was modeled after the 10mm Weck® Hem-o-lok® polymer clip (Teleflex Inc., Wayne, PA, USA). A 3D computer-aided design model of the Hem-o-lok® clip was reverse-engineered using commercial microscopy and printing was done using an Objet Connex500 multi-jetting system (Stratasys, Eden Prairie, MN, USA)...
July 18, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28712105/evaluation-of-a-low-cost-3d-printed-model-for-bronchoscopy-training
#7
Matteo Parotto, Joshua Qua Jiansen, Ahmed AboTaiban, Svetlana Ioukhova, Alisher Agzamov, Richard Cooper, Gerald O'Leary, Massimiliano Meineri
BACKGROUND: Flexible bronchoscopy is a fundamental procedure in anesthesia and critical care medicine. Learning this procedure is a complex task, but the use of simulation-based training provides significant advantages like enhanced patient safety. Access to bronchoscopy simulators may be limited in low resources settings. We developed a low-cost 3D printed bronchoscopy training model. METHODS: A parametric airway model was obtained from an online medical model repository and fabricated using a low-cost 3D printer...
July 16, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28711185/dosimetric-characterization-of-3d-printed-bolus-at-different-infill-percentage-for-external-photon-beam-radiotherapy
#8
Rosalinda Ricotti, Delia Ciardo, Floriana Pansini, Alessia Bazani, Stefania Comi, Ruggero Spoto, Samuele Noris, Federica Cattani, Guido Baroni, Roberto Orecchia, Andrea Vavassori, Barbara Alicja Jereczek-Fossa
BACKGROUND AND PURPOSE: 3D printing is rapidly evolving and further assessment of materials and technique is required for clinical applications. We evaluated 3D printed boluses with acrylonitrile butadiene styrene (ABS) and polylactide (PLA) at different infill percentage. MATERIAL AND METHODS: A low-cost 3D printer was used. The influence of the air inclusion within the 3D printed boluses was assessed thoroughly both with treatment planning system (TPS) and with physical measurements...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28707465/ultra-stretchable-and-self-healing-double-network-hydrogel-for-3d-printing-and-strain-sensor
#9
Sijun Liu, Lin Li
On the basis of the thermoreversible sol-gel transition behavior of κ-carrageenan in water, a double network (DN) hydrogel has been fabricated by combining an ionically crosslinked κ-carrageenan network with a covalently crosslinked polyacrylamide (PAAm) network. The κ-carrageenan/PAAm DN hydrogel demonstrated the excellent recoverability and significant self-healing capability (even when notched). More importantly, the warm pre-gel solution of κ-carrageenan/AAm is able to be used as an ink of a 3D printer to print complex 3D structures with remarkable mechanical strength after UV-exposure...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28702482/visualization-of-simulated-small-vessels-on-computed-tomography-using-a-model-based-iterative-reconstruction-technique
#10
Toru Higaki, Fuminari Tatsugami, Chikako Fujioka, Hiroaki Sakane, Yuko Nakamura, Yasutaka Baba, Makoto Iida, Kazuo Awai
This article describes a quantitative evaluation of visualizing small vessels using several image reconstruction methods in computed tomography. Simulated vessels with diameters of 1-6 mm made by 3D printer was scanned using 320-row detector computed tomography (CT). Hybrid iterative reconstruction (hybrid IR) and model-based iterative reconstruction (MBIR) were performed for the image reconstruction.
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28700740/navigation-accuracy-after-automatic-and-hybrid-surface-registration-in-sinus-and-skull-base-surgery
#11
Tanja Daniela Grauvogel, Paul Engelskirchen, Wiebke Semper-Hogg, Juergen Grauvogel, Roland Laszig
OBJECTIVE: Computer-aided-surgery in ENT surgery is mainly used for sinus surgery but navigation accuracy still reaches its limits for skull base procedures. Knowledge of navigation accuracy in distinct anatomical regions is therefore mandatory. This study examined whether navigation accuracy can be improved in specific anatomical localizations by using hybrid registration technique. STUDY DESIGN: Experimental phantom study. SETTING: Operating room...
2017: PloS One
https://www.readbyqxmd.com/read/28699619/highly-defined-3d-printed-chitosan-scaffolds-featuring-improved-cell-growth
#12
Lisa Elviri, Ruben Foresti, Carlo Bergonzi, Francesca Zimetti, Cinzia Marchi, Annalisa Bianchera, Franco Bernini, Marco Silvestri, Ruggero Bettini
The augmented demand for medical devices devoted to tissue regeneration and possessing a controlled micro-architecture means there is a need for industrial scale-up in the production of hydrogels. A new 3D printing technique was applied to the automation of a freeze-gelation method for the preparation of chitosan scaffolds with controlled porosity. For this aim, a dedicated 3D printer was built in-house: a preliminary effort has been necessary to explore the printing parameter space to optimize the printing results in terms of geometry, tolerances and mechanical properties of the product...
July 12, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28690429/3d-printer-generated-tissue-imolds-for-cleared-tissue-using-single-and-multi-photon-microscopy-for-deep-tissue-evaluation
#13
Sean J Miller, Jeffrey D Rothstein
BACKGROUND: Pathological analyses and methodology has recently undergone a dramatic revolution. With the creation of tissue clearing methods such as CLARITY and CUBIC, groups can now achieve complete transparency in tissue samples in nano-porous hydrogels. Cleared tissue is then imagined in a semi-aqueous medium that matches the refractive index of the objective being used. However, one major challenge is the ability to control tissue movement during imaging and to relocate precise locations post sequential clearing and re-staining...
2017: Biological Procedures Online
https://www.readbyqxmd.com/read/28678700/coloring-3d-printed-surfaces-by-thermoforming
#14
Yizhong Zhang, Yiying Tong, Kun Zhou
Decorating the surfaces of 3D printed objects with color textures is still not readily available in most consumer-level or even high-end 3D printers. Existing techniques such as hydrographics color transfer suffer from the issues of air pockets in concave regions and discoloration in overly stretched regions. We propose a novel thermoforming-based coloring technique to alleviate these problems as well as to simplify the overall procedure. Thermoforming is a widely used technique in industry for plastic thin shell product manufacturing by pressing heated plastic sheets onto molds using atmospheric pressure...
August 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28668582/selective-laser-sintering-sls-3d-printing-of-medicines
#15
Fabrizio Fina, Alvaro Goyanes, Simon Gaisford, Abdul W Basit
Selective laser sintering (SLS) 3-dimensional printing is currently used for industrial manufacturing of plastic, metallic and ceramic objects. To date there have been no reports on the use of SLS to fabricate oral drug loaded products; therefore, the aim of this work was to explore the suitability of SLS printing for manufacturing medicines. Two thermoplastic pharmaceutical grade polymers, Kollicoat IR (75% polyvinyl alcohol and 25% polyethylene glycol copolymer) and Eudragit L100-55 (50% methacrylic acid and 50% ethyl acrylate copolymer), with immediate and modified release characteristics respectively, were selected to investigate the versatility of a SLS printer...
June 29, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28666846/-3d-printing-in-neurosurgery-a-specific-model-for-patients-with-craniosynostosis
#16
Borja Jiménez Ormabera, Ricardo Díez Valle, Javier Zaratiegui Fernández, Marcos Llorente Ortega, Xabier Unamuno Iñurritegui, Sonia Tejada Solís
INTRODUCTION: Craniosynostosis is a rare condition and requires a personalised surgical approach, which is why we consider the use of 3D printed models beneficial in the surgical planning of this procedure. MATERIAL AND METHODS: Acrylonitrile butadiene styrene plastic skull models were designed and printed from CT images of patients between 3 and 6 months of age with craniosynostosis of different sutures. The models were used to simulate surgical procedures. RESULTS: Four models of four patients with craniosynostosis were produced: two with closure of the metopic suture and two with sagittal suture closure...
June 27, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28663863/geometrically-complex-3d-printed-phantoms-for-diffuse-optical-imaging
#17
Laura A Dempsey, Melissa Persad, Samuel Powell, Danial Chitnis, Jeremy C Hebden
Tissue-equivalent phantoms that mimic the optical properties of human and animal tissues are commonly used in diffuse optical imaging research to characterize instrumentation or evaluate an image reconstruction method. Although many recipes have been produced for generating solid phantoms with specified absorption and transport scattering coefficients at visible and near-infrared wavelengths, the construction methods are generally time-consuming and are unable to create complex geometries. We present a method of generating phantoms using a standard 3D printer...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28663663/design-optimization-for-accurate-flow-simulations-in-3d-printed-vascular-phantoms-derived-from-computed-tomography-angiography
#18
Kelsey Sommer, Richard L Izzo, Lauren Shepard, Alexander R Podgorsak, Stephen Rudin, Adnan H Siddiqui, Michael F Wilson, Erin Angel, Zaid Said, Michael Springer, Ciprian N Ionita
3D printing has been used to create complex arterial phantoms to advance device testing and physiological condition evaluation. Stereolithographic (STL) files of patient-specific cardiovascular anatomy are acquired to build cardiac vasculature through advanced mesh-manipulation techniques. Management of distal branches in the arterial tree is important to make such phantoms practicable. We investigated methods to manage the distal arterial flow resistance and pressure thus creating physiologically and geometrically accurate phantoms that can be used for simulations of image-guided interventional procedures with new devices...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28661043/3d-near-field-electrospinning-of-biomaterial-microfibers-with-potential-for-blended-microfiber-cell-loaded-gel-composite-structures
#19
Pouria Fattahi, Jordan T Dover, Justin L Brown
This paper describes the development of a novel low-cost and efficient method, 3D near-field electrospinning, to fabricate high-resolution, and repeatable 3D polymeric fiber patterns on nonconductive materials with potential use in tissue engineering. This technology is based on readily available hobbyist grade 3D printers. The result is exquisite control of the deposition of single fibers in an automated manner. Additionally, the fabrication of various fiber patterns, which are subsequently translated to unique cellular patterns, is demonstrated...
June 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28649157/use-of-patient-specific-3d-printed-neurovascular-phantoms-to-evaluate-the-clinical-utility-of-a-high-resolution-x-ray-imager
#20
S V Setlur Nagesh, M Russ, C N Ionita, D Bednarek, S Rudin
Modern 3D printing technology can fabricate vascular phantoms based on an actual human patient with a high degree of precision facilitating a realistic simulation environment for an intervention. We present two experimental setups using 3D printed patient-specific neurovasculature to simulate different disease anatomies. To simulate the human neurovasculature in the Circle of Willis, patient-based phantoms with aneurysms were 3D printed using a Objet Eden 260V printer. Anthropomorphic head phantoms and a human skull combined with acrylic plates simulated human head bone anatomy and x-ray attenuation...
February 11, 2017: Proceedings of SPIE
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