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https://www.readbyqxmd.com/read/29220337/basics-of-compounding-hot-melt-extrusion
#1
Seth DePasquale
Hot Melt Extrusion, a production process that has been around for quite some time, has the ability to produce innovative compounds not previously achievable with conventional methods. However, many variables need to be considered prior to production. The use of small-scale extruders and 3D printers provides compounders a pathway for developing new dosage forms at a minimal cost while initial research is being completed. This article discusses the uses of Hot Melt Extrusion, the equipment used, the current and future applications, and the challenges with the technology...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216869/horizontal-ridge-reconstruction-of-the-anterior-maxilla-using-customized-allogeneic-bone-blocks-with-a-minimally-invasive-technique-a-case-series
#2
Laurent Venet, Michel Perriat, Francesco Guido Mangano, Thomas Fortin
BACKGROUND: Different surgical procedures have been proposed to achieve horizontal ridge reconstruction of the anterior maxilla; all these procedures, however, require bone replacement materials to be adapted to the bone defect at the time of implantation, resulting in complex and time-consuming procedures. The purpose of this study was to describe how to use a 3D printed hardcopy model of the maxilla to prepare customized milled bone blocks, to be adapted on the bone defect areas using a minimally invasive subperiosteal tunneling technique...
December 8, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29188097/noninvasive-structural-and-microvascular-anatomy-of-oral-mucosae-using-handheld-optical-coherence-tomography
#3
Meng-Tsan Tsai, Yingdan Chen, Cheng-Yu Lee, Bo-Huei Huang, Nguyen Hoang Trung, Ya-Ju Lee, Yen-Li Wang
In this study, we demonstrated the feasibility of using a handheld optical coherence tomography (OCT) for in vivo visualizations of the microstructural and microvascular features of various oral mucosal types. To scan arbitrary locations of the oral mucosa, a scanning probe was developed, composed of a probe body fabricated by a 3D printer, miniaturized two-axis galvanometer, relay lenses, and reflective prism. With a 3D printing technique, the probe weight and the system volume were greatly reduced, enabling the effective improvement of imaging artifacts from unconscious motion and system complexity...
November 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29186036/a-new-bone-substitute-developed-from-3d-prints-of-polylactide-pla-loaded-with-collagen-i-an-in-vitro-study
#4
Ulrike Ritz, Rebekka Gerke, Hermann Götz, Stefan Stein, Pol Maria Rommens
Although a lot of research has been performed, large segmental bone defects caused by trauma, infection, bone tumors or revision surgeries still represent big challenges for trauma surgeons. New and innovative bone substitutes are needed. Three-dimensional (3D) printing is a novel procedure to create 3D porous scaffolds that can be used for bone tissue engineering. In the present study, solid discs as well as porous cage-like 3D prints made of polylactide (PLA) are coated or filled with collagen, respectively, and tested for biocompatibility and endotoxin contamination...
November 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29170727/grasping-state-estimation-of-printable-soft-gripper-using-electro-conductive-yarn
#5
Takahiro Matsuno, Zhongkui Wang, Shinichi Hirai
Automatic handling of many types of food materials are required to realize the automation of production of commercially prepared box lunches. A printable soft gripper was developed for food handling which is simple to produce with a 3D printer. However, the sensing ability of the printable soft gripper was not discussed in previous research. In this paper, a novel method for estimating the grasping state of a printable soft gripper using electro-conductive yarn is presented. Electro-conductive yarn is a conductive material, and the resistance of strings is changed by stretching...
2017: Robotics and Biomimetics
https://www.readbyqxmd.com/read/29159920/quality-assurance-for-a-six-degrees-of-freedom-table-using-a-3d-printed-phantom
#6
Kyle Woods, Ahmet S Ayan, Jeffrey Woollard, Nilendu Gupta
PURPOSE: To establish a streamlined end-to-end test of a 6 degrees-of-freedom (6DoF) robotic table using a 3D printed phantom for periodic quality assurance. METHODS: A 3D printed phantom was fabricated with translational and rotational offsets and an imbedded central ball-bearing (BB). The phantom underwent each step of the radiation therapy process: CT simulation in a straight orientation, plan generation using the treatment planning software, setup to offset marks at the linac, registration and corrected 6DoF table adjustments via hidden target test, delivery of a Winston-Lutz test to the BB, and verification of table positioning via field and laser lights...
November 21, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29134412/engineered-bone-scaffolds-with-dielectrophoresis-based-patterning-using-3d-printing
#7
Zhijie Huan, Henry K Chu, Hongbo Liu, Jie Yang, Dong Sun
Patterning of cells into a specific pattern is an important procedure in tissue engineering to facilitate tissue culture and ingrowth. In this paper, a new type of 3D-printed scaffold utilizing dielectrophoresis (DEP) for active cell seeding and patterning was proposed. This scaffold adopted a concentric-ring design that is similar to native bone tissues. The scaffold was fabricated with a commercial three-dimensional (3D) printer. Polylactic Acid (PLA) was selected as the material for the printer and the fabricated scaffold was coated with gold to enhance the conductivity for DEP manipulation...
November 13, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/29133713/three-dimensional-model-printing-for-surgery-on-arteriovenous-malformations
#8
Abhidha Shah, Bhavin Jankharia, Atul Goel
AIM: Surgery for intracranial complex vascular malformations can be quite exigent and involves considerable preoperative planning. Here, we present the advantages of using three-dimensional (3D) printed models as a preoperative investigational modality. MATERIAL AND METHODS: 3D printed models were made from thin-slice computed tomography (CT) angiography scans of 6 patients with arteriovenous malformations over an18-month period from August 2015 to December 2016...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29129573/3d-printed-uv-light-cured-polydimethylsiloxane-devices-for-drug-delivery
#9
Jenny Holländer, Risto Hakala, Jaakko Suominen, Niko Moritz, Jouko Yliruusi, Niklas Sandler
The goal of this work was to study the printability of PDMS with a semi-solid extrusion printer in combination with the UV-assisted crosslinking technology using UV-LED light to manufacture drug containing structures. Structures with different pore sizes and different drug loadings were prepared containing prednisolone as a model drug. The work showed that it was possible to print drug-free and drug-loaded drug delivery devices of PDMS with the 3D printing technique used in this study. The required UV-curing time to get sufficient crosslinking yield and mechanical strength was minimum three minutes...
November 9, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29128350/biomechanical-behavior-of-adhesive-cement-layer-and-periodontal-tissues-on-the-restored-teeth-with-zirconia-rbfdps-using-three-kinds-of-framework-design-3d-fea-study
#10
Ayana Uraba, Reina Nemoto, Kosuke Nozaki, Tasuku Inagaki, Satoshi Omori, Hiroyuki Miura
PURPOSE: To investigate stress and strain concentrations on resin-bonded fixed dental prostheses (RBFDPs) frameworks of different design using finite element analysis. METHODS: A human dry skull was scanned and models were produced using three-dimensional printer. After abutment preparation, three frameworks, including a three-unit RBFDP, and two-unit cantilevered RBFDPs using #21 and #23 for the abutment tooth, were fabricated. Scanned data were subtracted to define boundary of each structure...
November 8, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29116743/a-3d-printable-and-mechanically-robust-hydrogel-based-on-alginate-and-graphene-oxide
#11
Sijun Liu, Anil Kumar Bastola, Lin Li
Sodium alginate (SA) was used for the first time to noncovalently functionalize amino-graphene oxide (aGO) to produce the SA-functionalized GO, A-aGO. A-aGO was then filled into a double-network (DN) hydrogel consisting of an alginate network (SA) and a polyacrylamide (PAAm) network. Before UV curing, A-aGO was able to provide the SA/PAAm DN hydrogel with a remarkable thixotropic property, which is desirable for 3D printing. Thus, the A-aGO-filled DN hydrogel could be nicely used as an "ink" of a 3D printer to print complicated 3D structures with a high stackability and high shape fidelity...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29110921/3d-printed-versus-conventionally-cured-provisional-crown-and-bridge-dental-materials
#12
Anthony Tahayeri, MaryCatherine Morgan, Ana P Fugolin, Despoina Bompolaki, Avathamsa Athirasala, Carmem S Pfeifer, Jack L Ferracane, Luiz E Bertassoni
OBJECTIVES: To optimize the 3D printing of a dental material for provisional crown and bridge restorations using a low-cost stereolithography 3D printer; and compare its mechanical properties against conventionally cured provisional dental materials. METHODS: Samples were 3D printed (25×2×2mm) using a commercial printable resin (NextDent C&B Vertex Dental) in a FormLabs1+ stereolithography 3D printer. The printing accuracy of printed bars was determined by comparing the width, length and thickness of samples for different printer settings (printing orientation and resin color) versus the set dimensions of CAD designs...
October 27, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29102154/three-dimensional-printer-generated-patient-specific-phantom-for-artificial-in-vivo-dosimetry-in-radiotherapy-quality-assurance
#13
Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Kuniyasu Okudaira, Takahiro Aoyama, Hiroshi Oguchi, Masataka Komori, Mariko Kawamura, Kazuhiro Ohtakara, Hajime Monzen, Yoshiyuki Itoh, Shinji Naganawa
Pretreatment intensity-modulated radiotherapy quality assurance is performed using simple rectangular or cylindrical phantoms; thus, the dosimetric errors caused by complex patient-specific anatomy are absent in the evaluation objects. In this study, we construct a system for generating patient-specific three-dimensional (3D)-printed phantoms for radiotherapy dosimetry. An anthropomorphic head phantom containing the bone and hollow of the paranasal sinus is scanned by computed tomography (CT). Based on surface rendering data, a patient-specific phantom is formed using a fused-deposition-modeling-based 3D printer, with a polylactic acid filament as the printing material...
October 25, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29083312/bioprinted-chitosan-gelatin-thermosensitive-hydrogels-using-an-inexpensive-3d-printer
#14
Kevin D Roehm, Sundararajan V Madihally
The primary bottleneck in bioprinting cell-laden structures with carefully controlled spatial relation is a lack of biocompatible inks and printing conditions. In this regard, we explored using thermogelling chitosan-gelatin (CG) hydrogel as a novel bioprinting ink; CG hydrogels is unique in that it undergoes a spontaneous phase change at physiological temperature, and does not need post-processing. In addition, we used a low cost (<$800) compact 3D printer, and modified with a new extruder to print using disposable syringes and hypodermic needles...
October 30, 2017: Biofabrication
https://www.readbyqxmd.com/read/29075412/low-cost-method-for-obtaining-medical-rapid-prototyping-using-desktop-3d-printing-a-novel-technique-for-mandibular-reconstruction-planning
#15
Ignacio Velasco, Soheil Vahdani, Hector Ramos
BACKGROUND: Three-dimensional (3D) printing is relatively a new technology with clinical applications, which enable us to create rapid accurate prototype of the selected anatomic region, making it possible to plan complex surgery and pre-bend hardware for individual surgical cases. This study aimed to express our experience with the use of medical rapid prototype (MRP) of the maxillofacial region created by desktop 3D printer and its application in maxillofacial reconstructive surgeries...
September 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29069892/efficacy-of-a-three-dimensional-printed-training-simulator-for-endoscopic-biopsy-in-the-stomach
#16
Sunpyo Lee, Ji Yong Ahn, Minkyu Han, Gin Hyug Lee, Hee Kyong Na, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Hwoon-Yong Jung
Background/Aims: We used three-dimensional (3D) printing technology to create a new biopsy simulator for the stomach and investigated its efficacy and realism in endoscopic biopsy training. Methods: A novel stomach biopsy simulator, with 10 biopsy sites, was produced using a 3D printer. We enrolled 26 participants, including 10 residents, six first-year fellows, five second-year fellows, and five faculty members. We recorded and reviewed five training sessions and evaluated the simulator with questionnaires using a 7-point Likert scale...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29066279/formulation-of-3d-printed-tablet-for-rapid-drug-release-by-fused-deposition-modeling-fdm-screening-polymers-for-drug-release-drug-polymer-miscibility-and-printability
#17
Nayan Solanki, Md Tahsin, Ankita Shah, Abu T M Serajuddin
The primary aim of this study was to identify pharmaceutically acceptable amorphous polymers for producing 3D printed tablets of a model drug, haloperidol, for rapid release by fused deposition modeling (FDM). Filaments for 3D printing were prepared by hot melt extrusion at 150°C with 10 and 20% w/w of haloperidol using Kollidon(®) VA64, Kollicoat(®) IR, Affinsiol(™)15 cP and HPMCAS either individually or as binary blends (Kollidon(®) VA64+Affinisol(™)15 cP, 1:1; Kollidon(®) VA64+HPMCAS, 1:1). Dissolution of crushed extrudates was studied at pH 2 and 6...
October 21, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29064377/3d-printing-nano-conductive-multi-walled-carbon-nanotube-scaffolds-for-nerve-regeneration
#18
Se-Jun Lee, Wei Zhu, Margaret Nowicki, Grace Lee, Dong Nyoung Heo, Junghoon Kim, Yi Zuo, Lijie Grace Zhang
In recent years, the development of tissue-engineered 3D scaffolds for various regenerative engineering applications has been widely investigated. Hydrogel polymers are extensively used as tissue engineering scaffold materials due to their unique biocompatible features. However, hydrogel based scaffolds often suffer from weak mechanical strength and a lack of functional groups to enhance cell adhesion. Hence, nanomaterials, such as carbon nanotubes (CNTs), have been introduced to modify the surface properties of scaffolds, thus enhancing the interaction between the neural cells and biomaterials...
October 24, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29062628/toward-self-growing-soft-robots-inspired-by-plant-roots-and-based-on-additive-manufacturing-technologies
#19
Ali Sadeghi, Alessio Mondini, Barbara Mazzolai
In this article, we present a novel class of robots that are able to move by growing and building their own structure. In particular, taking inspiration by the growing abilities of plant roots, we designed and developed a plant root-like robot that creates its body through an additive manufacturing process. Each robotic root includes a tubular body, a growing head, and a sensorized tip that commands the robot behaviors. The growing head is a customized three-dimensional (3D) printer-like system that builds the tubular body of the root in the format of circular layers by fusing and depositing a thermoplastic material (i...
September 1, 2017: Soft Robotics
https://www.readbyqxmd.com/read/29060723/proposal-of-custom-made-wrist-orthoses-based-on-3d-modelling-and-3d-printing
#20
Mauren Abreu de Souza, Cristiane Schmitz, Marcelo Marega Pinhel, Joao A Palma Setti, Percy Nohama
Accessibility to three-dimensional (3D) technologies, such as 3D scanning systems and additive manufacturing (like 3D printers), allows a variety of 3D applications. For medical applications in particular, these modalities are gaining a lot of attention enabling several opportunities for healthcare applications. The literature brings several cases applying both technologies, but none of them focus on the spreading of how this technology could benefit the health segment. This paper proposes a new methodology, which employs both 3D modelling and 3D printing for building orthoses, which could better fit the demands of different patients...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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