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3d printer

Hyeonji Hong, Eunseop Yeom, Ho Seong Ji, Hyun Dong Kim, Kyung Chun Kim
Spatial and temporal variations of the hemodynamic features occur under pulsatile conditions in complex vessel geometry. Wall shear stress affected by the disturbed flow can result in endothelial cell dysfunction, which leads to atherogenesis and thrombosis. Therefore, detailed understanding of the hemodynamic characteristics in a curved stenosed channel is highly important when examining the pathological effects of hemodynamic phenomena on the progression of atherosclerosis. The present study measures the velocity fields of pulsatile flows with three different Reynolds numbers in 3D curved vessel models with stenosis using time-resolved particle image velocimetry (PIV)...
2017: PloS One
Susanna Fafenrot, Nils Grimmelsmann, Martin Wortmann, Andrea Ehrmann
Fused deposition modeling (FDM) is a three-dimensional (3D) printing technology that is usually performed with polymers that are molten in a printer nozzle and placed line by line on the printing bed or the previous layer, respectively. Nowadays, hybrid materials combining polymers with functional materials are also commercially available. Especially combinations of polymers with metal particles result in printed objects with interesting optical and mechanical properties. The mechanical properties of objects printed with two of these metal-polymer blends were compared to common poly (lactide acid) (PLA) printed objects...
October 19, 2017: Materials
Aleš Gregor, Eva Filová, Martin Novák, Jakub Kronek, Hynek Chlup, Matěj Buzgo, Veronika Blahnová, Věra Lukášová, Martin Bartoš, Alois Nečas, Jan Hošek
BACKGROUND: The primary objective of Tissue engineering is a regeneration or replacement of tissues or organs damaged by disease, injury, or congenital anomalies. At present, Tissue engineering repairs damaged tissues and organs with artificial supporting structures called scaffolds. These are used for attachment and subsequent growth of appropriate cells. During the cell growth gradual biodegradation of the scaffold occurs and the final product is a new tissue with the desired shape and properties...
2017: Journal of Biological Engineering
Valerie S Morash, Alexander Russomanno, R Brent Gillespie, Sile OModhrain
Refreshable displays for tactile graphics are typically composed of pins that have smaller diameters and spacing than standard braille dots. We investigated configurations of high-density pins to form braille text on such displays using non-refreshable stimuli produced with a 3D printer. Normal dot braille (diameter 1.5 mm) was compared to high-density dot braille (diameter 0.75 mm) wherein each normal dot was rendered by high-density simulated pins alone or in a cluster of pins configured in a diamond, X, or square; and to "blobs" that could result from covering normal braille and high-density multi-pin configurations with a thin membrane...
October 13, 2017: IEEE Transactions on Haptics
Frank Alexander, Sebastian Eggert, Joachim Wiest
Sensor-based cellular microphysiometry is a technique that allows non-invasive, label-free, real-time monitoring of living cells that can greatly improve the predictability of toxicology testing by removing the influence of biochemical labels. In this work, the Intelligent Mobile Lab for In Vitro Diagnostics (IMOLA-IVD) was utilized to perform cellular microphysiometry on 3D multicellular spheroids. Using a commercial 3D printer, 3 × 3 microwell arrays were fabricated to maintain nine previously cultured HepG2 spheroids on a single BioChip...
October 14, 2017: Cytotechnology
Taryn Hodgdon, Raman Danrad, Midhir J Patel, Stacy E Smith, Michael L Richardson, David H Ballard, Sayed Ali, Anthony Paul Trace, Carolynn M DeBenedectis, Matthew E Zygmont, Leon Lenchik, Summer J Decker
The Association of University Radiologists Radiology Research Alliance Task Force on three-dimensional (3D) printing presents a review of the logistic considerations for establishing a clinical service using this new technology, specifically focused on implications for radiology. Specific topics include printer selection for 3D printing, software selection, creating a 3D model for printing, providing a 3D printing service, research directions, and opportunities for radiologists to be involved in 3D printing...
October 10, 2017: Academic Radiology
Lei Zhang, Mu Li, Zeyao Li, Xiermaimaiti Kedeer, Long Wang, Ziwen Fan, Chang Chen
BACKGROUND: Small pulmonary nodules are a common problem, especially with the wide implementation of lung cancer-screening program. This poses a great challenge to thoracic surgeons because of the difficulty of nodule localization. We recently built an efficient, customized navigational template using 3-dimensional (3D) printing technology to facilitate the procedure of lung nodule localization. This study aims to investigate its feasibility in clinical application. METHODS: Patients with peripheral lung nodules (<2 cm) were enrolled...
September 1, 2017: Journal of Thoracic and Cardiovascular Surgery
R House, N Rajaram, S M Tarlo
Background: Three-dimensional (3D) printing is being increasingly used in manufacturing and by small business entrepreneurs and home hobbyists. Exposure to airborne emissions during 3D printing raises the issue of whether there may be adverse health effects associated with these emissions. Aims: We present a case of a worker who developed asthma while using 3D printers, which illustrates that respiratory problems may be associated with 3D printer emissions. Case report: The patient was a 28-year-old self-employed businessman with a past history of asthma in childhood, which had resolved completely by the age of eight...
August 23, 2017: Occupational Medicine
Elise DeSimone, Kristin Schacht, Alexandra Pellert, Thomas Scheibel
Bioinks, 3D cell culture systems which can be printed, are still in the early development stages. Currently, extensive research is going into designing printers to be more accommodating to bioinks, designing scaffolds with stiff materials as support structures for the often soft bioinks, and modifying the bioinks themselves. Recombinant spider silk proteins, a potential biomaterial component for bioinks, have high biocompatibility, can be processed into several morphologies and can be modified with cell adhesion motifs to enhance their bioactivity...
October 4, 2017: Biofabrication
Jiaxiang Zhang, Weiwei Yang, Anh Q Vo, Xin Feng, Xingyou Ye, Dong Wuk Kim, Michael A Repka
The objective of this study was to develop a new approach for fabrication of zero order release of active pharmaceutical ingredients (APIs) using hot-melt extrusion (HME) and 3D printing technology to generate tablets with specific 3D structures. By correlating the geometry of the 3D printed tablets with their dissolution and drug release rates, mathematical models that have been developed to describe drug release mechanisms were also studied. Acetaminophen was used as a model drug, and Benecel™ hydroxypropyl methylcellulose (HPMC) E5 and Soluplus(®) were used to formulate nine fuse depositional 3D-printed tablets with different inner core fill densities and outside shell thicknesses...
December 1, 2017: Carbohydrate Polymers
Christian S Favero, Jeryl D English, Benjamin E Cozad, John O Wirthlin, Megan M Short, F Kurtis Kasper
INTRODUCTION: Three-dimensional (3D) printing technologies enable production of orthodontic models from digital files; yet a range of variables associated with the process could impact the accuracy and clinical utility of the models. The objective of this study was to investigate the effect of print layer height on the accuracy of orthodontic models printed 3 dimensionally using a stereolithography format printer and to compare the accuracy of orthodontic models fabricated with several commercially available 3D printers...
October 2017: American Journal of Orthodontics and Dentofacial Orthopedics
Sergey Ishutov, Franciszek J Hasiuk, Dawn Jobe, Susan Agar
Three-dimensional (3D) printing is capable of transforming intricate digital models into tangible objects, allowing geoscientists to replicate the geometry of 3D pore networks of sedimentary rocks. We provide a refined method for building scalable pore-network models ("proxies") using stereolithography 3D printing that can be used in repeated flow experiments (e.g., core flooding, permeametry, porosimetry). Typically, this workflow involves two steps, model design and 3D printing. In this study, we explore how the addition of post-processing and validation can reduce uncertainty in the 3D-printed proxy accuracy (difference of proxy geometry from the digital model)...
September 28, 2017: Ground Water
Lu-Qiu Zhou, Ming-Wu Lou, Guo-Chang Chen, Zhi-Song Jiu, Yun-Xia Shen, Lin Lu
OBJECTIVE: To evaluate the value of 640-slice 3D CT angiography (3D-CTA) plus 3D printing for improving the outcomes of surgeries for intracranial aneurysms. METHODS: Sixty patients with intracranial aneurysm were randomly divided into trial group (n=30) and control group (n=30). The control group received routine surgery, and the simulation models of the intracranial aneurysm in trial group was printed using a 3D printer using the imaging data from 3D-CTA. Using the simulation model, the surgery was designed and planned before operation (including surgical approaches and placement of clips) and simulation surgery was also conducted...
September 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
A B Stefaniak, R F LeBouf, M G Duling, J Yi, A B Abukabda, C R McBride, T R Nurkiewicz
Fused deposition modeling (FDM™), or three-dimensional (3D) printing has become routine in industrial, occupational and domestic environments. We have recently reported that 3D printing emissions (3DPE) are complex mixtures, with a large ultrafine particulate matter component. Additionally, we and others have reported that inhalation of xenobiotic particles in this size range is associated with an array of cardiovascular dysfunctions. Sprague-Dawley rats were exposed to 3DPE aerosols via nose-only exposure for ~3h...
November 15, 2017: Toxicology and Applied Pharmacology
Michael William Entz, David Ryan King, Steven Poelzing
With the sudden increase in affordable manufacturing technologies, the relationship between experimentalists and the designing process for laboratory equipment is rapidly changing. While experimentalists are still dependent on engineers and manufacturers for precision electrical, mechanical, and optical equipment, it has become a realistic option for in house manufacturing of other laboratory equipment with less precise design requirements. This is possible due to decreasing costs and increasing functionality of desktop 3D printers and 3D design software...
September 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
Hongning Song, Qing Zhou, Lan Zhang, Qing Deng, Yijia Wang, Bo Hu, Tuantuan Tan, Jinling Chen, Yiteng Pan, Fazhi He
The novel 3-dimensional printing (3DP) technique has shown its ability to assist personalized cardiac intervention therapy. This study aimed to determine the feasibility of 3D-printed left atrial appendage (LAA) models based on 3D transesophageal echocardiography (3D TEE) data and their application value in treating LAA occlusions.Eighteen patients with transcatheter LAA occlusion, and preprocedure 3D TEE and cardiac computed tomography were enrolled. 3D TEE volumetric data of the LAA were acquired and postprocessed for 3DP...
September 2017: Medicine (Baltimore)
Naomi Claire Paxton, Willi Smolan, Thomas Böck, Ferry P W Melchels, Juergen Groll, Tomasz Juengst
The development and formulation of printable inks for extrusion-based 3D bioprinting has been a major challenge in the field of biofabrication. Inks, often polymer solutions with the addition of crosslinking to form hydrogels, must not only display adequate mechanical properties for the chosen application, but also show high biocompatibility as well as printability. Here we describe a reproducible two-step method for the assessment of the printability of inks for bioprinting, focussing firstly on screening ink formulations to assess fibre formation and the ability to form 3D constructs before presenting a method for the rheological evaluation of inks to characterise the yield point, shear thinning and recovery behaviour...
September 20, 2017: Biofabrication
Mehran Abolghasemibizaki, Reza Mohammadi
HYPOTHESIS: Impacting on a superhydrophobic surface, water droplet spreads to a pancake shape and then retracts and bounces off. Although the collision time is mostly in the order of couple of 10ms for millimetric droplets, researchers have shown recently that decorating the superhydrophobic surface with a single macrotexture or intersecting ridge reduces this contact time if the droplet hits the texture or the intersection exactly in the center. Hence, covering the surface with ridges should address this hitting point restriction...
September 8, 2017: Journal of Colloid and Interface Science
Stephanie E Adamczak, Frank J Bova, Daniel J Hoh
Spinal instrumentation often involves placing implants without direct visualization of their trajectory or proximity to adjacent neurovascular structures. Two-dimensional fluoroscopy is commonly used to navigate implant placement, but with the advent of computed tomography, followed by the invention of a mobile scanner with an open gantry, three-dimensional (3D) navigation is now widely used. This article critically appraises the available literature to assess the influence of 3D navigation on radiation exposure, accuracy of instrumentation, operative time, and patient outcomes...
October 2017: Neurosurgery Clinics of North America
Fangzheng Li, Chunying Liu, Xuexiong Song, Yanjun Huan, Shansong Gao, Zhongling Jiang
Access to adequate anatomical specimens can be an important aspect in learning the anatomy of domestic animals. In this study, the authors utilized a structured light scanner and fused deposition modeling (FDM) printer to produce highly accurate animal skeletal models. First, various components of the bovine skeleton, including the femur, the fifth rib, and the sixth cervical (C6) vertebra were used to produce digital models. These were then used to produce 1:1 scale physical models with the FDM printer. The anatomical features of the digital models and three-dimensional (3D) printed models were then compared with those of the original skeletal specimens...
September 15, 2017: Anatomical Sciences Education
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