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Jun-Qi Lu, Shan Wang, Jia Yin, Shan Wu, Yan He, Hui-Min Zheng, Hua-Fang Sheng, Hong-Wei Zhou
OBJECTIVE: To establish a machine learning model based on gut microbiota for predicting the level of trimethylamine N-oxide (TMAO) metabolism in vivo after choline intake to provide guidance of individualized precision diet and evidence for screening population at high risks of cardiovascular disease. METHODS: We quantified plasma levels of TMAO in 18 healthy volunteers before and 8 h after a choline challenge (ingestion of two boiled eggs). The volunteers were divided into two groups with increased or decreased TMAO level following choline challenge...
March 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
James M Bardes, Dana Gray, Alison Wilson
BACKGROUND: Organisms trapped in biofilms cause more than 80% of medical infections. Significant investments are being made to develop methods of removing these biofilms. The endOclear(®) device is reported to remove biofilm from endotracheal tubes (ETTs) and to decrease pneumonia rates and ventilator time. METHODS: This was an observational study performed at a university Level 1 trauma center intensive care unit. A series of 40 ETTs were collected at extubation, with half of the patients having been treated daily with the endOclear(®) device...
April 2017: Surgical Infections
Burcin Oncul, Duygu Karakis, Funda Dogruman Al
PURPOSE: Xerostomia can diminish the quality of life, leads to changes in normal chemical composition of saliva and oral microbiata, and increases the risk for opportunistic infections, such as Candida albicans. Various artificial salivas have been considered for patients with xerostomia. However, the knowledge on the antifungal and antiadhesive activity of artificial saliva substitutes is limited. The aim of the present study was to evaluate influence of two artificial salivas on the adhesion of Candida albicans to the polymethylmethacrylate disc specimens...
April 2015: Journal of Advanced Prosthodontics
Bhaswati Sinha, Muni Rubens
CONTEXT: Advancement in HIV treatment has evolved over the last two decades with the discovery of new drugs and approaches. Studies have demonstrated that HIV-infected individuals have elevated immune activation even during effective antiretroviral therapy. Persistently elevated immune activation has been one of the main obstacles against developing an effective approach for curing HIV. OBJECTIVE: This review examines the mechanism of microbial translocation in HIV-infected individuals and currently investigated potential therapeutic approaches...
April 2014: Immunopharmacology and Immunotoxicology
Reza Akrami, Yousef Iri, Hosseinali Khoshbavar Rostami, Majid Razeghi Mansour
The dietary supplementation of fructooligosaccharide (FOS) in stellate sturgeon juvenile, Acipenser stellatus (with mean initial body weight of 30.16 ± 0.14 g) was evaluated for the effect on growth, autochthonous intestinal microbiata and hemato-immunological parameters for 11 weeks. FOS was added at a level of 0, 1% and 2% to the commercial pellet diet (BioMar). At the end of the experiment, growth parameters, survival rate, lactobacillus bacterial population, hematological and immunological parameters were determined...
October 2013: Fish & Shellfish Immunology
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