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https://www.readbyqxmd.com/read/29614002/expression-tissue-localization-and-serodiagnostic-potential-of-echinococcus-granulosus-leucine-aminopeptidase
#1
Maodi Wu, Min Yan, Jing Xu, Yuqing Liang, Xiaobin Gu, Yue Xie, Bo Jing, Weimin Lai, Xuerong Peng, Guangyou Yang
Echinococcus granulosus is the causative agent of cystic echinococcosis (CE), a widespread parasitic zoonosis. Leucine aminopeptidases (LAPs) of the M17 peptidase family have important functions in regulating the balance of catabolism and anabolism, cell maintenance, growth and defense. In this study, we presented a bioinformatic characterization and experimentally determined the tissue distribution characteristics of E. granulosus LAP (Eg-LAP), and explored its potential value for diagnosis of CE in sheep based on indirect ELISA...
April 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29587675/expression-of-reg-iv-and-sox9-and-their-correlation-in-human-gastric-cancer
#2
Na Zhang, Dandan Chai, Huifen Du, Kesheng Li, Wenguang Xie, Xingwen Li, Rong Yang, Xiaowen Lian, Yang Xu
BACKGROUND: Reg IV is a member of the regenerating gene family and has been demonstrated to be overexpressed in gastric cancer. However, the functional mechanism of Reg IV in gastric cancer is still unclear. METHODS: Expression of Reg IV and SOX9 were investigated by immunohistochemistry (IHC) and real-time PCR, and the correlation between the expression of Reg IV and SOX9 was analyzed in gastric cancer tissues. Reg IV expression vectors and a siRNA of Reg IV and SOX9 were transfected into human gastric cancer cells and the protein and mRNA levels of Reg IV and SOX9 were investigated by western blot and real-time PCR...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29568705/activation-of-cd4-and-cd8-t-cell-receptors-and-regulatory-t-cells-in-response-to-human-proteins
#3
Borros M Arneth
This study assessed in detail the influence of four different human proteins on the activation of CD4+ and CD8+ T lymphocytes and on the formation of regulatory T cells. Human whole-blood samples were incubated with four different human proteins. The effects of these proteins on the downstream immune-system response, on the expression of extracellular activation markers on and intracellular cytokines in T lymphocytes, and on the number of regulatory T cells (T-reg cells) were investigated via flow cytometry...
2018: PeerJ
https://www.readbyqxmd.com/read/29541032/the-influence-of-co-2-and-exercise-on-hypobaric-hypoxia-induced-pulmonary-edema-in-rats
#4
Ryan L Sheppard, Joshua M Swift, Aaron Hall, Richard T Mahon
Introduction: Individuals with a known susceptibility to high altitude pulmonary edema (HAPE) demonstrate a reduced ventilation response and increased pulmonary vasoconstriction when exposed to hypoxia. It is unknown whether reduced sensitivity to hypercapnia is correlated with increased incidence and/or severity of HAPE, and while acute exercise at altitude is known to exacerbate symptoms the effect of exercise training on HAPE susceptibility is unclear. Purpose: To determine if chronic intermittent hypercapnia and exercise increases the incidence of HAPE in rats...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29518224/in-vivo-ultrasound-and-biometric-measurements-predict-the-empty-body-chemical-composition-in-nellore-cattle
#5
A M Castilhos, C L Francisco, R H Branco, S F M Bonilha, M E Z Mercadante, P R L Meirelles, C M Pariz, A M Jorge
Evaluation of the body chemical composition of beef cattle can only be measured postmortem and those data cannot be used in real production scenarios to adjust nutritional plans. The objective of this study was to develop multiple linear regression equations from in vivo measurements, such as ultrasound parameters [backfat thickness (uBFT, mm), rump fat thickness (uRF, mm), and ribeye area (uLMA, cm2)], shrunk body weight (SBW, kg), age (AG, d), hip height (HH, m), as well as from postmortem measurements (composition of the 9th to 11th rib section) to predict the empty body and carcass chemical composition for Nellore cattle...
March 6, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29512686/reg3a-overexpression-suppresses-gastric-cancer-cell-invasion-proliferation-and-promotes-apoptosis-through-pi3k-akt-signaling-pathway
#6
Yan-Song Qiu, Guang-Jun Liao, Ning-Ning Jiang
Gastric cancer (GC) is the second most common cause of cancer-related deaths. In recent years some essential factors for resolution were identified, but the clinical trials still lack the effective methods to treat or monitor the disease progression. Regenerating islet-derived 3α (REG3A) is a member of REG protein family. Previous studies have investigated the altered expression of REG3A in various cancers. In this investigtion we aimed at the biological function and the underlying molecular mechanism of REG3A in GC...
February 28, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29301535/inhibition-of-histone-deacetylase-activity-rescues-inflammatory-cystic-fibrosis-lung-disease-by-modulating-innate-and-adaptive-immune-responses
#7
Manish Bodas, Steven Mazur, Taehong Min, Neeraj Vij
BACKGROUND: Chronic lung disease resulting from dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) and NFκB-mediated neutrophilic-inflammation forms the basis of CF-related mortality. Here we aimed to evaluate if HDAC inhibition controls Pseudomonas-aeruginosa-lipopolysaccharide (Pa-LPS) induced airway inflammation and CF-lung disease. METHODS: For in vitro experiments, HEK293-cells were transfected with IL-8 or NFκB-firefly luciferase, and SV40-renilla- luciferase reporter constructs or ΔF508-CFTR-pCEP, followed by treatment with suberoylanilide hydroxamic acid (SAHA), Trichostatin-A (TSA) and/or TNFα...
January 4, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29297851/ram-locus-is-a-key-regulator-to-trigger-multidrug-resistance-in-enterobacter-aerogenes
#8
Alexander Molitor, Chloë E James, Séamus Fanning, Jean-Marie Pagès, Anne Davin-Regli
PURPOSE: Several genetic regulators belonging to AraC family are involved in the emergence of MDR isolates of E. aerogenes due to alterations in membrane permeability. Compared with the genetic regulator Mar, RamA may be more relevant towards the emergence of antibiotic resistance. METHODOLOGY: Focusing on the global regulators, Mar and Ram, we compared the amino acid sequences of the Ram repressor in 59 clinical isolates and laboratory strains of E. aerogenes. Sequence types were associated with their corresponding multi-drug resistance phenotypes and membrane protein expression profiles using MIC and immunoblot assays...
February 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29188369/immune-modulation-of-th1-th2-and-t-reg-transcriptional-factors-differing-from-cytokine-levels-in-schistosoma-japonicum-infection
#9
Amel Farwa, Chao He, Longfei Xia, Hong Zhou
In spite of long-term integrated control programs for Schistosoma japonicum infection in China, the infection is still persistent due to its zoonotic transmission and disease severity which further complicate its control. Th1, Th2, and T-reg cells are involved in S. japonicum immunity; however, their exact roles in immunopathology of this infection are still questionable. Therefore, the monitoring of these T cell subsets' immune responses during a primary infection of S. japonicum at both transcriptional (mRNA) and protein (cytokines) levels would be essential to point out...
January 2018: Parasitology Research
https://www.readbyqxmd.com/read/29055152/predominance-of-regorafenib-over-sorafenib-restoration-of-membrane-bound-mica-in-hepatocellular-carcinoma-cells
#10
Jun Arai, Kaku Goto, Anthony Stephanou, Yasushi Tanoue, Sayaka Ito, Ryosuke Muroyama, Yasuo Matsubara, Ryo Nakagawa, Sayuri Morimoto, Yoshimi Kaise, Lay Ahyoung Lim, Hitoshi Yoshida, Naoya Kato
BACKGROUND AND AIM: The multi-kinase inhibitor regorafenib (REG) was recently demonstrated to be effective in patients with sorafenib (SOR)-resistant hepatocellular carcinoma (HCC). Interestingly, SOR is known to enhance the accumulation of membrane-bound MHC class I polypeptide-related sequence A (mMICA) in HCC cells, and to block production of soluble MICA (sMICA), an immunological decoy. In addition, MICA is associated with HCC in patients with chronic hepatitis C. We have now compared the impact of REG and SOR on MICA in HCC cells, as well as the immunotherapeutic implications thereof...
October 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29042392/renal-and-cardiovascular-effects-of-sodium-glucose-cotransporter-2-sglt2-inhibition-in-combination-with-loop-diuretics-in-diabetic-patients-with-chronic-heart-failure-recede-chf-protocol-for-a-randomised-controlled-double-blind-cross-over-trial
#11
Natalie A Mordi, Ify R Mordi, Jagdeep S Singh, Fatima Baig, Anna-Maria Choy, Rory J McCrimmon, Allan D Struthers, Chim C Lang
INTRODUCTION: Type 2 diabetes (T2D) and heart failure (HF) are a frequent combination, where treatment options remain limited. There has been increasing interest around the sodium-glucose cotransporter 2 (SGLT2) inhibitors and their use in patients with HF. Data on the effect of SGLT2 inhibitor use with diuretics are limited. We hypothesise that SGLT2 inhibition may augment the effects of loop diuretics and the benefits of SGLT2 inhibitors may extend beyond those of their metabolic (glycaemic parameters and weight loss) and haemodynamic parameters...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28955777/up-regulation-of-selenoprotein-p-and-hip-pap-mrnas-in-hepatocytes-by-intermittent-hypoxia-via-down-regulation-of-mir-203
#12
Tomoko Uchiyama, Hiroyo Ota, Asako Itaya-Hironaka, Ryogo Shobatake, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Mai Makino, Hiroshi Kimura, Maiko Takeda, Chiho Ohbayashi, Shin Takasawa
Sleep apnea syndrome is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]) and is a risk factor for insulin resistance/type 2 diabetes. However, the mechanisms linking IH stress and insulin resistance remain elusive. We exposed human hepatocytes (JHH5, JHH7, and HepG2) to experimental IH or normoxia for 24 h, measured mRNA levels by real-time reverse transcription polymerase chain reaction (RT-PCR), and found that IH significantly increased the mRNA levels of selenoprotein P (SELENOP) - a hepatokine - and hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) - one of REG (Regenerating gene) family...
September 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28945764/high-incidence-of-extensive-chronic-graft-versus-host-disease-in-patients-with-the-reg3a-rs7588571-non-gg-genotype
#13
Daisuke Koyama, Makoto Murata, Ryo Hanajiri, Shingo Okuno, Sonoko Kamoshita, Jakrawadee Julamanee, Erina Takagi, Daiki Hirano, Kotaro Miyao, Reona Sakemura, Tatsunori Goto, Fumihiko Hayakawa, Aika Seto, Yukiyasu Ozawa, Koichi Miyamura, Seitaro Terakura, Tetsuya Nishida, Hitoshi Kiyoi
Regenerating islet-derived protein 3 alpha (REG3A) is a biomarker of lower gastrointestinal graft-versus-host disease (GVHD); however, the biological role of REG3A in the pathophysiology of GVHD is not understood. Here, we examined the association between a single nucleotide polymorphism in the REG3A gene, rs7588571, which is located upstream and within 2 kb of the REG3A gene, and transplant outcomes including the incidence of GVHD. The study population consisted of 126 adult Japanese patients who had undergone bone marrow transplantation from a HLA-matched sibling...
2017: PloS One
https://www.readbyqxmd.com/read/28833818/considering-land-sea-interactions-and-trade-offs-for-food-and-biodiversity
#14
Richard S Cottrell, Aysha Fleming, Elizabeth A Fulton, Kirsty L Nash, Reg A Watson, Julia L Blanchard
With the human population expected to near 10 billion by 2050, and diets shifting towards greater per-capita consumption of animal protein, meeting future food demands will place ever-growing burdens on natural resources and those dependent on them. Solutions proposed to increase the sustainability of agriculture, aquaculture, and capture fisheries have typically approached development from single sector perspectives. Recent work highlights the importance of recognising links among food sectors, and the challenge cross-sector dependencies create for sustainable food production...
August 21, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28713091/-s100a4-macc-1-reg-4-promising-biomarkers-of-metastasis-in-cancers
#15
Bartosz Czerniak, Dorota Olszewska-Słonina, Anna Cwynar
Metastasis is one of the key steps in cancer, which is exposed to a large group of patients diagnosed with malignancy. Initiating the process of metastasis is to move the epithelial - mesenchymal cells wherein the cancer cells by blood and lymph vessels, penetrate to distant sites of the body to form secondary foci. Cancer biomarkers are group of molecules (typically proteins) secreted mainly by tumor cells themselves having use in diagnosis of cancer, determining the length of survival in patients or in the assessment of the body's response to treatment...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28670647/farming-and-the-geography-of-nutrient-production-for-human-use-a-transdisciplinary-analysis
#16
Mario Herrero, Philip K Thornton, Brendan Power, Jessica R Bogard, Roseline Remans, Steffen Fritz, James S Gerber, Gerald Nelson, Linda See, Katharina Waha, Reg A Watson, Paul C West, Leah H Samberg, Jeannette van de Steeg, Eloise Stephenson, Mark van Wijk, Petr Havlík
BACKGROUND: Information about the global structure of agriculture and nutrient production and its diversity is essential to improve present understanding of national food production patterns, agricultural livelihoods, and food chains, and their linkages to land use and their associated ecosystems services. Here we provide a plausible breakdown of global agricultural and nutrient production by farm size, and also study the associations between farm size, agricultural diversity, and nutrient production...
April 2017: Lancet. Planetary Health
https://www.readbyqxmd.com/read/28667906/the-sglt2-inhibitor-empagliflozin-improves-the-primary-diabetic-complications-in-zdf-rats
#17
Sebastian Steven, Matthias Oelze, Alina Hanf, Swenja Kröller-Schön, Fatemeh Kashani, Siyer Roohani, Philipp Welschof, Maximilian Kopp, Ute Gödtel-Armbrust, Ning Xia, Huige Li, Eberhard Schulz, Karl J Lackner, Leszek Wojnowski, Serge P Bottari, Philip Wenzel, Eric Mayoux, Thomas Münzel, Andreas Daiber
Hyperglycemia associated with inflammation and oxidative stress is a major cause of vascular dysfunction and cardiovascular disease in diabetes. Recent data reports that a selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), empagliflozin (Jardiance® ), ameliorates glucotoxicity via excretion of excess glucose in urine (glucosuria) and significantly improves cardiovascular mortality in type 2 diabetes mellitus (T2DM). The overarching hypothesis is that hyperglycemia and glucotoxicity are upstream of all other complications seen in diabetes...
October 2017: Redox Biology
https://www.readbyqxmd.com/read/28599462/detection-of-tax-specific-ctls-in-lymph-nodes-of-adult-t-cell-leukemia-lymphoma-patients-and-its-association-with-foxp3-positivity-of-regulatory-t-cell-function
#18
Ayako Ichikawa, Hiroaki Miyoshi, Fumiko Arakawa, Junichi Kiyasu, Kensaku Sato, Daisuke Niino, Yoshizo Kimura, Maki Yoshida, Riko Kawano, Hiroko Muta, Yasuo Sugita, Koichi Ohshima
Human T-cell lymphotropic virus type (HTLV)-1 Tax is a viral protein that has been reported to be important in the proliferation of adult T-cell leukemia/lymphoma (ATLL) cells and to be a target of HTLV-1-specific cytotoxic T lymphocytes (CTLs). However, it is not clear how Tax-specific CTLs behave in lymph nodes of ATLL patients. The present study analyzed the immunostaining of Tax-specific CTLs. Furthermore, ATLL tumor cells are known to be positive for forkhead box P3 (Foxp3)and to have a regulatory T (Treg)-cell-like function...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28588752/inducible-protein-10-as-a-predictive-marker-of-antiviral-hepatitis-c-treatment-a-systematic-review
#19
REVIEW
Bastian Neesgaard, Morten Ruhwald, Nina Weis
AIM: To investigate interferon-γ-inducible protein-10's (IP-10) potential to anticipate rapid (RVR)- and sustained virological responses (SVR) to chronic hepatitis C (CHC) treatment. METHODS: We included case series examining RVR or SVR in relation to 24 or 48 wk treatment for CHC, in patients treatment free for at least six months, with genotype 1 or 4, and in relation to 24 wk treatment for genotype 2 and 3, with pegylated interferon in combination with ribavirin...
May 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28584149/different-resistance-mechanisms-for-cadazolid-and-linezolid-in-clostridium-difficile-found-by-whole-genome-sequencing-analysis
#20
Patrick Caspers, Hans H Locher, Philippe Pfaff, Sarah Diggelmann, Georg Rueedi, Daniel Bur, Daniel Ritz
Cadazolid (CDZ) is a new antibiotic currently in clinical development for the treatment of Clostridium difficile infections. CDZ interferes with the bacterial protein synthesis machinery. The aim of the present study was to identify resistance mechanisms for CDZ and compare the results to those obtained for linezolid (LZD) in C. difficile by whole-genome sequencing (WGS) of strains generated by in vitro passages and to those obtained for LZD-resistant clinical isolates. Clones of C. difficile 630 selected with CDZ during 46 passages had a maximally 4-fold increase in CDZ MIC, while the LZD MIC for clones selected with LZD increased up to 16-fold...
August 2017: Antimicrobial Agents and Chemotherapy
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